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Conserved domains on  [gi|15240012|ref|NP_201457|]
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Phototropic-responsive NPH3 family protein [Arabidopsis thaliana]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 13605777)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) and NPH3 domain-containing protein may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 254-506 1.14e-108

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


:

Pssm-ID: 460777  Cd Length: 218  Bit Score: 327.14  E-value: 1.14e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240012   254 ELWFEDLTQLSLPIFKTVILSMRSGDLSSDIIESCLICYAKKHIPGILRsnRKPPSSSSTAVSENEQRELLETITSNLPL 333
Cdd:pfam03000   1 DWWFEDLSELSIDLFKRVISAMKSKGMKPEVIGEALMHYAKKWLPGLSR--SSSSSASRSEDDNSKQRELLETIVSLLPS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240012   334 DKSSISstTRFLFGLLRTAIILNAAEICRDLLERKIGSQLERATLDDLLVPSYSyLNETLYDVDLVerilghfldtleqs 413
Cdd:pfam03000  79 EKGSVS--CSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYS-GEETLYDVDLK-------------- 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240012   414 ntaivevdgkspslmlVGKLIDGFLAEIASDANLKSDKFYNLAISLPDQARLYDDGLYRAVDVYLKAHPWVSEAEREKIC 493
Cdd:pfam03000 142 ----------------VAKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERKRLC 205

                         250
                  ....*....|...
gi 15240012   494 GVMDCQKLTLEAC 506
Cdd:pfam03000 206 RLMDCQKLSLEAC 218
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 12-160 5.98e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18312:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 105  Bit Score: 130.53  E-value: 5.98e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240012  12 AWFCTTGLPSDIEIEVDDMTFHLHKFPLMSKSRKLHRLITEQETRSSSsmalitvidpkveetdkkgkgheieddkeeee 91
Cdd:cd18312   1 SWFRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSSSESDPS-------------------------------- 48

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15240012  92 veeqeieengypHIKLEDFPGSSESFEMVAKFCYGVKMDLSASTVVPLRCAAEHLEMTEEYSPDNLISK 160
Cdd:cd18312  49 ------------EIELNDFPGGAEAFELVAKFCYGMPINLTATNVVGLRCAAEYLEMTESGNLGNLIDK 105
 
Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 254-506 1.14e-108

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


Pssm-ID: 460777  Cd Length: 218  Bit Score: 327.14  E-value: 1.14e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240012   254 ELWFEDLTQLSLPIFKTVILSMRSGDLSSDIIESCLICYAKKHIPGILRsnRKPPSSSSTAVSENEQRELLETITSNLPL 333
Cdd:pfam03000   1 DWWFEDLSELSIDLFKRVISAMKSKGMKPEVIGEALMHYAKKWLPGLSR--SSSSSASRSEDDNSKQRELLETIVSLLPS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240012   334 DKSSISstTRFLFGLLRTAIILNAAEICRDLLERKIGSQLERATLDDLLVPSYSyLNETLYDVDLVerilghfldtleqs 413
Cdd:pfam03000  79 EKGSVS--CSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYS-GEETLYDVDLK-------------- 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240012   414 ntaivevdgkspslmlVGKLIDGFLAEIASDANLKSDKFYNLAISLPDQARLYDDGLYRAVDVYLKAHPWVSEAEREKIC 493
Cdd:pfam03000 142 ----------------VAKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERKRLC 205

                         250
                  ....*....|...
gi 15240012   494 GVMDCQKLTLEAC 506
Cdd:pfam03000 206 RLMDCQKLSLEAC 218
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 12-160 5.98e-36

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 130.53  E-value: 5.98e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240012  12 AWFCTTGLPSDIEIEVDDMTFHLHKFPLMSKSRKLHRLITEQETRSSSsmalitvidpkveetdkkgkgheieddkeeee 91
Cdd:cd18312   1 SWFRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSSSESDPS-------------------------------- 48

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15240012  92 veeqeieengypHIKLEDFPGSSESFEMVAKFCYGVKMDLSASTVVPLRCAAEHLEMTEEYSPDNLISK 160
Cdd:cd18312  49 ------------EIELNDFPGGAEAFELVAKFCYGMPINLTATNVVGLRCAAEYLEMTESGNLGNLIDK 105
 
Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 254-506 1.14e-108

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


Pssm-ID: 460777  Cd Length: 218  Bit Score: 327.14  E-value: 1.14e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240012   254 ELWFEDLTQLSLPIFKTVILSMRSGDLSSDIIESCLICYAKKHIPGILRsnRKPPSSSSTAVSENEQRELLETITSNLPL 333
Cdd:pfam03000   1 DWWFEDLSELSIDLFKRVISAMKSKGMKPEVIGEALMHYAKKWLPGLSR--SSSSSASRSEDDNSKQRELLETIVSLLPS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240012   334 DKSSISstTRFLFGLLRTAIILNAAEICRDLLERKIGSQLERATLDDLLVPSYSyLNETLYDVDLVerilghfldtleqs 413
Cdd:pfam03000  79 EKGSVS--CSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYS-GEETLYDVDLK-------------- 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240012   414 ntaivevdgkspslmlVGKLIDGFLAEIASDANLKSDKFYNLAISLPDQARLYDDGLYRAVDVYLKAHPWVSEAEREKIC 493
Cdd:pfam03000 142 ----------------VAKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERKRLC 205

                         250
                  ....*....|...
gi 15240012   494 GVMDCQKLTLEAC 506
Cdd:pfam03000 206 RLMDCQKLSLEAC 218
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 12-160 5.98e-36

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 130.53  E-value: 5.98e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240012  12 AWFCTTGLPSDIEIEVDDMTFHLHKFPLMSKSRKLHRLITEQETRSSSsmalitvidpkveetdkkgkgheieddkeeee 91
Cdd:cd18312   1 SWFRDTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSSSESDPS-------------------------------- 48

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15240012  92 veeqeieengypHIKLEDFPGSSESFEMVAKFCYGVKMDLSASTVVPLRCAAEHLEMTEEYSPDNLISK 160
Cdd:cd18312  49 ------------EIELNDFPGGAEAFELVAKFCYGMPINLTATNVVGLRCAAEYLEMTESGNLGNLIDK 105
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-146 7.95e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 7.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240012  21 SDIEIEVDDMTFHLHKFPLMSKSRKLHRLITEQETRSSSSmalitvidpkveetdkkgkgheieddkeeeeveeqeieen 100
Cdd:cd18186   2 CDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSS---------------------------------------- 41

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 15240012 101 gypHIKLEDFpgSSESFEMVAKFCYGVKMDLSASTVVPLRCAAEHL 146
Cdd:cd18186  42 ---EIELDDV--SPEAFEALLDYIYTGELELSEENVEELLAAADKL 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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