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Conserved domains on  [gi|15239632|ref|NP_200251|]
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S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 92-249 9.99e-19

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 80.42  E-value: 9.99e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632  92 YSAVPLRYEMAQRMVGSVGDwSSVKTALDLGCGRGILLNAVATQlkktgsSGRVVGLDRS--MtttLSTLRtAHIEGVQE 169
Cdd:COG2226   1 FDRVAARYDGREALLAALGL-RPGARVLDLGCGTGRLALALAER------GARVTGVDISpeM---LELAR-ERAAEAGL 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632 170 YVTCREGDVRRLPFSDNYFDVVVSAVFLHTIgkeygqktveaaAERMRVLGEAVRVLKPGGVGVVWDLV--HVPEYVRRL 247
Cdd:COG2226  70 NVEFVVGDAEDLPFPDGSFDLVISSFVLHHL------------PDPERALAEIARVLKPGGRLVVVDFSppDLAELEELL 137


                ..
gi 15239632 248 QE 249
Cdd:COG2226 138 AE 139
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 92-249 9.99e-19

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 80.42  E-value: 9.99e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632  92 YSAVPLRYEMAQRMVGSVGDwSSVKTALDLGCGRGILLNAVATQlkktgsSGRVVGLDRS--MtttLSTLRtAHIEGVQE 169
Cdd:COG2226   1 FDRVAARYDGREALLAALGL-RPGARVLDLGCGTGRLALALAER------GARVTGVDISpeM---LELAR-ERAAEAGL 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632 170 YVTCREGDVRRLPFSDNYFDVVVSAVFLHTIgkeygqktveaaAERMRVLGEAVRVLKPGGVGVVWDLV--HVPEYVRRL 247
Cdd:COG2226  70 NVEFVVGDAEDLPFPDGSFDLVISSFVLHHL------------PDPERALAEIARVLKPGGRLVVVDFSppDLAELEELL 137


                ..
gi 15239632 248 QE 249
Cdd:COG2226 138 AE 139
PRK08317 PRK08317
hypothetical protein; Provisional
 117-236 3.64e-18

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 81.52  E-value: 3.64e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632  117 TALDLGCGRGILLNAVAtqlKKTGSSGRVVGLDRSmtTTLSTLRTAHIEGVQEYVTCREGDVRRLPFSDNYFDVVVSavf 196
Cdd:PRK08317  22 RVLDVGCGPGNDARELA---RRVGPEGRVVGIDRS--EAMLALAKERAAGLGPNVEFVRGDADGLPFPDGSFDAVRS--- 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 15239632  197 lhtigkeygQKTVEAAAERMRVLGEAVRVLKPGGVGVVWD 236
Cdd:PRK08317  94 ---------DRVLQHLEDPARALAEIARVLRPGGRVVVLD 124
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 119-230 8.38e-18

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 76.83  E-value: 8.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632   119 LDLGCGRGILLNAVATQLKktgssGRVVGLDRS--MtttLSTLRtAHIEGVQEYVTCREGDVRRLPFSDNYFDVVVSAVF 196
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGG-----ARVTGVDLSpeM---LERAR-ERAAEAGLNVEFVQGDAEDLPFPDGSFDLVVSSGV 72

                          90       100       110
                  ....*....|....*....|....*....|....
gi 15239632   197 LHTIGKEygqktveaaaERMRVLGEAVRVLKPGG 230
Cdd:pfam13649  73 LHHLPDP----------DLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 117-238 1.33e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.14  E-value: 1.33e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632 117 TALDLGCGRGILLNAVATQLKKtgssgRVVGLDRSMTTtLSTLRTAHIEGVQEYVTCREGDVRRLPF-SDNYFDVVVSAV 195
Cdd:cd02440   1 RVLDLGCGTGALALALASGPGA-----RVTGVDISPVA-LELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISDP 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 15239632 196 FLHTIgkeygqktveaAAERMRVLGEAVRVLKPGGVGVVWDLV 238
Cdd:cd02440  75 PLHHL-----------VEDLARFLEEARRLLKPGGVLVLTLVL 106
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 117-237 4.17e-09

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 55.73  E-value: 4.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632   117 TALDLGCGRGILLNAVAtqlKKTGSSGRVVGLDRSmTTTLSTLRTAHIegVQEYVTCREGDVRRLPFSDNYFDVVvsavf 196
Cdd:TIGR01934  42 KVLDVACGTGDLAIELA---KSAPDRGKVTGVDFS-SEMLEVAKKKSE--LPLNIEFIQADAEALPFEDNSFDAV----- 110

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 15239632   197 lhTIGkeYGQKTVeaaAERMRVLGEAVRVLKPGGVGVVWDL 237
Cdd:TIGR01934 111 --TIA--FGLRNV---TDIQKALREMYRVLKPGGRLVILEF 144
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 92-249 9.99e-19

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 80.42  E-value: 9.99e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632  92 YSAVPLRYEMAQRMVGSVGDwSSVKTALDLGCGRGILLNAVATQlkktgsSGRVVGLDRS--MtttLSTLRtAHIEGVQE 169
Cdd:COG2226   1 FDRVAARYDGREALLAALGL-RPGARVLDLGCGTGRLALALAER------GARVTGVDISpeM---LELAR-ERAAEAGL 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632 170 YVTCREGDVRRLPFSDNYFDVVVSAVFLHTIgkeygqktveaaAERMRVLGEAVRVLKPGGVGVVWDLV--HVPEYVRRL 247
Cdd:COG2226  70 NVEFVVGDAEDLPFPDGSFDLVISSFVLHHL------------PDPERALAEIARVLKPGGRLVVVDFSppDLAELEELL 137


                ..
gi 15239632 248 QE 249
Cdd:COG2226 138 AE 139
PRK08317 PRK08317
hypothetical protein; Provisional
 117-236 3.64e-18

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 81.52  E-value: 3.64e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632  117 TALDLGCGRGILLNAVAtqlKKTGSSGRVVGLDRSmtTTLSTLRTAHIEGVQEYVTCREGDVRRLPFSDNYFDVVVSavf 196
Cdd:PRK08317  22 RVLDVGCGPGNDARELA---RRVGPEGRVVGIDRS--EAMLALAKERAAGLGPNVEFVRGDADGLPFPDGSFDAVRS--- 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 15239632  197 lhtigkeygQKTVEAAAERMRVLGEAVRVLKPGGVGVVWD 236
Cdd:PRK08317  94 ---------DRVLQHLEDPARALAEIARVLRPGGRVVVLD 124
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 119-230 8.38e-18

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 76.83  E-value: 8.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632   119 LDLGCGRGILLNAVATQLKktgssGRVVGLDRS--MtttLSTLRtAHIEGVQEYVTCREGDVRRLPFSDNYFDVVVSAVF 196
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGG-----ARVTGVDLSpeM---LERAR-ERAAEAGLNVEFVQGDAEDLPFPDGSFDLVVSSGV 72

                          90       100       110
                  ....*....|....*....|....*....|....
gi 15239632   197 LHTIGKEygqktveaaaERMRVLGEAVRVLKPGG 230
Cdd:pfam13649  73 LHHLPDP----------DLEAALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 119-234 2.72e-17

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 75.39  E-value: 2.72e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632   119 LDLGCGRGILLNAvatqLKKTGSsgRVVGLDRSMTTtlstLRTAHIEGVQEYVTCREGDVRRLPFSDNYFDVVVSAVFLH 198
Cdd:pfam08241   1 LDVGCGTGLLTEL----LARLGA--RVTGVDISPEM----LELAREKAPREGLTFVVGDAEDLPFPDNSFDLVLSSEVLH 70

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 15239632   199 TIgkeygqktveaaAERMRVLGEAVRVLKPGGVGVV 234
Cdd:pfam08241  71 HV------------EDPERALREIARVLKPGGILII 94
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 111-240 1.40e-14

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 71.34  E-value: 1.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632  111 DWSSVK---TALDLGCGRGILLNAVAtqlKKTGSSGRVVGLDRSmtttLSTLRTA----HIEGVQEYVTCREGDVRRLPF 183
Cdd:PRK00216  45 KWLGVRpgdKVLDLACGTGDLAIALA---KAVGKTGEVVGLDFS----EGMLAVGreklRDLGLSGNVEFVQGDAEALPF 117

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 15239632  184 SDNYFDVVvsavflhTIGkeYGQKTVEaaaERMRVLGEAVRVLKPGGVGVVWDLVHV 240
Cdd:PRK00216 118 PDNSFDAV-------TIA--FGLRNVP---DIDKALREMYRVLKPGGRLVILEFSKP 162
arsM PRK11873
arsenite methyltransferase;
117-250 7.51e-14

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 69.98  E-value: 7.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632  117 TALDLGCGRGI--LLNAvatqlKKTGSSGRVVGLDrsMTTTLSTL-----RTAHIEGVqEYvtcREGDVRRLPFSDNYFD 189
Cdd:PRK11873  80 TVLDLGSGGGFdcFLAA-----RRVGPTGKVIGVD--MTPEMLAKaranaRKAGYTNV-EF---RLGEIEALPVADNSVD 148

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15239632  190 VVVSAVFLHTigkeygqktveaAAERMRVLGEAVRVLKPGGVGVVWDLVH---VPEYVRRLQEL 250
Cdd:PRK11873 149 VIISNCVINL------------SPDKERVFKEAFRVLKPGGRFAISDVVLrgeLPEEIRNDAEL 200
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 117-238 1.33e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.14  E-value: 1.33e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632 117 TALDLGCGRGILLNAVATQLKKtgssgRVVGLDRSMTTtLSTLRTAHIEGVQEYVTCREGDVRRLPF-SDNYFDVVVSAV 195
Cdd:cd02440   1 RVLDLGCGTGALALALASGPGA-----RVTGVDISPVA-LELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISDP 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 15239632 196 FLHTIgkeygqktveaAAERMRVLGEAVRVLKPGGVGVVWDLV 238
Cdd:cd02440  75 PLHHL-----------VEDLARFLEEARRLLKPGGVLVLTLVL 106
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 117-241 3.24e-11

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 60.33  E-value: 3.24e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632 117 TALDLGCGRGILLNAVAtqlKKTGSsgRVVGLDRSMTTTLSTLRTAHIEGVQEYVTCREGDVRRLPFsDNYFDVVVSAVF 196
Cdd:COG2230  54 RVLDIGCGWGGLALYLA---RRYGV--RVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPA-DGQFDAIVSIGM 127

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 15239632 197 LHTIGKEYgqktveaaaeRMRVLGEAVRVLKPGGVGvvwdLVHVP 241
Cdd:COG2230 128 FEHVGPEN----------YPAYFAKVARLLKPGGRL----LLHTP 158
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 116-234 4.43e-11

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 59.26  E-value: 4.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632 116 KTALDLGCGRGILLNAvatqLKKTGSsgRVVGLDRSmtttLSTLRTAHIEGVQEYVTCREGDVRRLPFSDNYFDVVVS-A 194
Cdd:COG2227  26 GRVLDVGCGTGRLALA----LARRGA--DVTGVDIS----PEALEIARERAAELNVDFVQGDLEDLPLEDGSFDLVICsE 95

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 15239632 195 VFLHTigkeygqktveaaAERMRVLGEAVRVLKPGGVGVV 234
Cdd:COG2227  96 VLEHL-------------PDPAALLRELARLLKPGGLLLL 122
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
117-231 5.29e-10

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 55.60  E-value: 5.29e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632 117 TALDLGCGRGILLNAVATQLKKtgssGRVVGLDRS--MtttLSTLRTAHiegvqEYVTCREGDVRRLPFSDNyFDVVVSA 194
Cdd:COG4106   4 RVLDLGCGTGRLTALLAERFPG----ARVTGVDLSpeM---LARARARL-----PNVRFVVADLRDLDPPEP-FDLVVSN 70

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15239632 195 VFLHTIgkeygqktveaaAERMRVLGEAVRVLKPGGV 231
Cdd:COG4106  71 AALHWL------------PDHAALLARLAAALAPGGV 95
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 112-229 8.23e-10

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 57.98  E-value: 8.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632  112 WSSVKTA---LDLGCGRGILLNAVAtqlKKTGSSGRVVGLDRSMTTTLSTLRTAHIEGVQEYVTCR--EGDVRRLPFSDN 186
Cdd:PLN02233  68 WSGAKMGdrvLDLCCGSGDLAFLLS---EKVGSDGKVMGLDFSSEQLAVAASRQELKAKSCYKNIEwiEGDATDLPFDDC 144

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 15239632  187 YFDVVvsavflhTIGkeYGQKTVeaaAERMRVLGEAVRVLKPG 229
Cdd:PLN02233 145 YFDAI-------TMG--YGLRNV---VDRLKAMQEMYRVLKPG 175
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 117-237 4.17e-09

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 55.73  E-value: 4.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632   117 TALDLGCGRGILLNAVAtqlKKTGSSGRVVGLDRSmTTTLSTLRTAHIegVQEYVTCREGDVRRLPFSDNYFDVVvsavf 196
Cdd:TIGR01934  42 KVLDVACGTGDLAIELA---KSAPDRGKVTGVDFS-SEMLEVAKKKSE--LPLNIEFIQADAEALPFEDNSFDAV----- 110

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 15239632   197 lhTIGkeYGQKTVeaaAERMRVLGEAVRVLKPGGVGVVWDL 237
Cdd:TIGR01934 111 --TIA--FGLRNV---TDIQKALREMYRVLKPGGRLVILEF 144
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
100-247 1.18e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 53.46  E-value: 1.18e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632 100 EMAQRMVGSVGDwSSVKTALDLGCGRGILlnavATQLKKTGssGRVVGLDRS--MtttlstLRTAHIEGVqeYVTCREGD 177
Cdd:COG4976  33 LLAEELLARLPP-GPFGRVLDLGCGTGLL----GEALRPRG--YRLTGVDLSeeM------LAKAREKGV--YDRLLVAD 97

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15239632 178 VRRLPFSDNYFDVVVSAVFLHTIGkeygqktveaaaERMRVLGEAVRVLKPGG--VGVVWDL------VHVPEYVRRL 247
Cdd:COG4976  98 LADLAEPDGRFDLIVAADVLTYLG------------DLAAVFAGVARALKPGGlfIFSVEDAdgsgryAHSLDYVRDL 163
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 117-234 1.57e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 53.77  E-value: 1.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632 117 TALDLGCGRGILLNAVATQLKktgssGRVVGLDRSmTTTLSTLRTAHIEGVQEYVTCREGDVRRL-PFSDNYFDVVVSAV 195
Cdd:COG0500  29 RVLDLGCGTGRNLLALAARFG-----GRVIGIDLS-PEAIALARARAAKAGLGNVEFLVADLAELdPLPAESFDLVVAFG 102

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 15239632 196 FLHTIGKEygqktveaaaERMRVLGEAVRVLKPGGVGVV 234
Cdd:COG0500 103 VLHHLPPE----------EREALLRELARALKPGGVLLL 131
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 117-250 5.42e-08

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 51.73  E-value: 5.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632 117 TALDLGCGRGILlnavATQLKKTGSSGRVVGLDRSMTTTLSTLRTAHIEGVQEyVTCREGDVRRlPFSDNYFDVVVSAVF 196
Cdd:COG2813  52 RVLDLGCGYGVI----GLALAKRNPEARVTLVDVNARAVELARANAAANGLEN-VEVLWSDGLS-GVPDGSFDLILSNPP 125

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15239632 197 LHTigkeyGQKTVEAAAERMrvLGEAVRVLKPGgvGVVWdLV---HVPeYVRRLQEL 250
Cdd:COG2813 126 FHA-----GRAVDKEVAHAL--IADAARHLRPG--GELW-LVanrHLP-YERKLEEL 171
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 100-231 7.18e-08

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 52.29  E-value: 7.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632   100 EMAQRMVGSVGDWSSVKTA--LDLGCGRGILLNAvatqLKKTGSSGRVVGLDRSMtTTLSTLRTAhiegVQEYVTCREGD 177
Cdd:TIGR02072  18 EMAKRLLALLKEKGIFIPAsvLDIGCGTGYLTRA----LLKRFPQAEFIALDISA-GMLAQAKTK----LSENVQFICGD 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15239632   178 VRRLPFSDNYFDVVVSAVFLHTIGKeygqktveaaaeRMRVLGEAVRVLKPGGV 231
Cdd:TIGR02072  89 AEKLPLEDSSFDLIVSNLALQWCDD------------LSQALSELARVLKPGGL 130
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 116-253 1.32e-07

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 50.11  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632   116 KTALDLGCGRGILLNAVAtqlKKTGSSGRVVGLDRSMtttlSTLRTAHIEGVQ---EYVTCREGDVRRLP--FSDNYFDV 190
Cdd:pfam13847   5 MRVLDLGCGTGHLSFELA---EELGPNAEVVGIDISE----EAIEKARENAQKlgfDNVEFEQGDIEELPelLEDDKFDV 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15239632   191 VVSAVFLHTIgkeygqktveaaAERMRVLGEAVRVLKPGGVGVV---WDLVHVPEYVRRLQELRME 253
Cdd:pfam13847  78 VISNCVLNHI------------PDPDKVLQEILRVLKPGGRLIIsdpDSLAELPAHVKEDSTYYAG 131
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
117-240 6.00e-07

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 49.36  E-value: 6.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632   117 TALDLGCGRGILLNAVAtqlKKTGSSGRVVGLDRSMTTTLSTLRTAHIEGVQ--EYVtcrEGDVRRLPFSDNYFDVVvsa 194
Cdd:pfam01209  45 KFLDVAGGTGDWTFGLS---DSAGSSGKVVGLDINENMLKEGEKKAKEEGKYniEFL---QGNAEELPFEDDSFDIV--- 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 15239632   195 vflhTIGkeYGQKTVeaaAERMRVLGEAVRVLKPGGVGVVWDLVHV 240
Cdd:pfam01209 116 ----TIS--FGLRNF---PDYLKVLKEAFRVLKPGGRVVCLEFSKP 152
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 116-231 1.21e-05

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 44.89  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632   116 KTALDLGCGRGILlnavATQLKKTGSSGRVVGLDRSMTTTLSTLRTAHIEGVqEYVTCREGDVRRlPFSDNYFDVVVSAV 195
Cdd:pfam05175  33 GKVLDLGCGAGVL----GAALAKESPDAELTMVDINARALESARENLAANGL-ENGEVVASDVYS-GVEDGKFDLIISNP 106

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 15239632   196 FLHTigkeyGQKTVEAAAERMrvLGEAVRVLKPGGV 231
Cdd:pfam05175 107 PFHA-----GLATTYNVAQRF--IADAKRHLRPGGE 135
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 119-231 7.05e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 41.20  E-value: 7.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632   119 LDLGCGRGILLNAVATQLkktgSSGRVVGLDRSmTTTLSTLRTAHIEGVQEYVTCREGDVRRLPFSD-NYFDVVVSAVFL 197
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAL----PGLEYTGLDIS-PAALEAARERLAALGLLNAVRVELFQLDLGELDpGSFDVVVASNVL 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 15239632   198 HtigkeygqktveAAAERMRVLGEAVRVLKPGGV 231
Cdd:pfam08242  76 H------------HLADPRAVLRNIRRLLKPGGV 97
PRK14968 PRK14968
putative methyltransferase; Provisional
 116-261 1.78e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.42  E-value: 1.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632  116 KTALDLGCGRGIllnaVATQLKKTGssGRVVGLDRSMTTTLSTLRTAHIEGVQEY-VTCREGDVRRlPFSDNYFDVVV-S 193
Cdd:PRK14968  25 DRVLEVGTGSGI----VAIVAAKNG--KKVVGVDINPYAVECAKCNAKLNNIRNNgVEVIRSDLFE-PFRGDKFDVILfN 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632  194 AVFLHT--------------IGKEYGQKTVEaaaermRVLGEAVRVLKPGGVG--VVWDLVHVPEYVRRLQELRME-EIR 256
Cdd:PRK14968  98 PPYLPTeeeeewddwlnyalSGGKDGREVID------RFLDEVGRYLKPGGRIllLQSSLTGEDEVLEYLEKLGFEaEVV 171


                 ....*
gi 15239632  257 VSKRV 261
Cdd:PRK14968 172 AEEKF 176
PLN02244 PLN02244
tocopherol O-methyltransferase
 102-264 2.36e-04

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 42.04  E-value: 2.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632  102 AQ-RMVGSVGDWSSV--------KTALDLGCGRGillnavatqlkktGSSGRVVGLDRSMTT--TLSTLRTAHI------ 164
Cdd:PLN02244  97 AQiRMIEESLAWAGVpdddekrpKRIVDVGCGIG-------------GSSRYLARKYGANVKgiTLSPVQAARAnalaaa 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632  165 EGVQEYVTCREGDVRRLPFSDNYFDVVVSAvflhtigkEYGqktvEAAAERMRVLGEAVRVLKPGG--VGVVW---DLVH 239
Cdd:PLN02244 164 QGLSDKVSFQVADALNQPFEDGQFDLVWSM--------ESG----EHMPDKRKFVQELARVAAPGGriIIVTWchrDLEP 231

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15239632  240 ---------------------------VPEYVRRLQELRMEEIRV---SKRVTAF 264
Cdd:PLN02244 232 getslkpdeqklldkicaayylpawcsTSDYVKLAESLGLQDIKTedwSEHVAPF 286
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 110-193 6.04e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 40.51  E-value: 6.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632 110 GDWSSVK---TALDLGCGRGILLNAVATQLKKtgssGRVVGLDRSMTTTLSTLRTAHIEGVQEYVTCREGDVRRLP--FS 184
Cdd:COG4123  30 AAFAPVKkggRVLDLGTGTGVIALMLAQRSPG----ARITGVEIQPEAAELARRNVALNGLEDRITVIHGDLKEFAaeLP 105


                ....*....
gi 15239632 185 DNYFDVVVS 193
Cdd:COG4123 106 PGSFDLVVS 114
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
176-231 1.13e-03

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 38.69  E-value: 1.13e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 15239632 176 GDVR-RLPFSDNYFDVVVSAVFLHTIGKEYGqktveaaaerMRVLGEAVRVLKPGGV 231
Cdd:COG4627  34 GDLTdPLPFPDNSVDAIYSSHVLEHLDYEEA----------PLALKECYRVLKPGGI 80
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 90-262 1.31e-03

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 38.78  E-value: 1.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632  90 FFYSAVpLRYEMAQRMVGSVGDWSSvKTALDLGCGRG-ILLNAvatqlkktGSSG-RVVGLD------RSMTTTLSTLRT 161
Cdd:COG1041   4 FFYPGS-LDPRLARALVNLAGAKEG-DTVLDPFCGTGtILIEA--------GLLGrRVIGSDidpkmvEGARENLEHYGY 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632 162 ahiegvqEYVTCREGDVRRLPFSDNYFDVVVS----AVFLHTIGKEYgQKTVEAAAErmrvlgEAVRVLKPGG-VGVVWD 236
Cdd:COG1041  74 -------EDADVIRGDARDLPLADESVDAIVTdppyGRSSKISGEEL-LELYEKALE------EAARVLKPGGrVVIVTP 139

                       170       180
                ....*....|....*....|....*...
gi 15239632 237 lVHVPEYVRR--LQELRMEEIRVSKRVT 262
Cdd:COG1041 140 -RDIDELLEEagFKVLERHEQRVHKSLT 166
PRK06922 PRK06922
class I SAM-dependent methyltransferase;
111-236 1.90e-03

class I SAM-dependent methyltransferase;


Pssm-ID: 180751 [Multi-domain]  Cd Length: 677  Bit Score: 39.47  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632  111 DWSSVKTALDLGCGRGILLNAVATQLKKTgssgRVVGLDRSMTTTLSTLRTAHIEGVQEYVtcREGDVRRLP--FSDNYF 188
Cdd:PRK06922 415 DYIKGDTIVDVGAGGGVMLDMIEEETEDK----RIYGIDISENVIDTLKKKKQNEGRSWNV--IKGDAINLSssFEKESV 488

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15239632  189 DVVVSAVFLHTI-------GKEYGQKTVEAAaermrvLGEAVRVLKPGGVGVVWD 236
Cdd:PRK06922 489 DTIVYSSILHELfsyieyeGKKFNHEVIKKG------LQSAYEVLKPGGRIIIRD 537
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 171-239 2.02e-03

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 39.10  E-value: 2.02e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15239632  171 VTCREGDVRRLPFSDNYFDVVVSAvflhtigkeygqKTVEAAAERMRVLGEAVRVLKPGGVGVVWDLVH 239
Cdd:PLN02490 162 CKIIEGDAEDLPFPTDYADRYVSA------------GSIEYWPDPQRGIKEAYRVLKIGGKACLIGPVH 218
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
116-193 2.72e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 37.96  E-value: 2.72e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15239632 116 KTALDLGCGRGILlnAVATQLKktgSSGRVVGLDRSmTTTLSTLRTAhIEGVQEYVTCREGDVRRLPFSDNyFDVVVS 193
Cdd:COG2263  47 KTVLDLGCGTGML--AIGAALL---GAKKVVGVDID-PEALEIAREN-AERLGVRVDFIRADVTRIPLGGS-VDTVVM 116
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 175-229 6.20e-03

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 36.59  E-value: 6.20e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 15239632  175 EGDVRRLPFSDNYFDVVvsavflhTIGkeYGQKTVeaaAERMRVLGEAVRVLKPG 229
Cdd:PLN02232  32 EGDAIDLPFDDCEFDAV-------TMG--YGLRNV---VDRLRAMKEMYRVLKPG 74
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 116-230 6.23e-03

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 37.51  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632   116 KTALDLGCGRGILlnavATQLKKTGSSgRVVGLDRSMTTTLSTLRTAHIEGVQEYVTCREGDVRRLpfSDNYFDVVVSAV 195
Cdd:TIGR00406 161 KNVIDVGCGSGIL----SIAALKLGAA-KVVGIDIDPLAVESARKNAELNQVSDRLQVKLIYLEQP--IEGKADVIVANI 233

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 15239632   196 FLHTIgkeygqktveaaaerMRVLGEAVRVLKPGG 230
Cdd:TIGR00406 234 LAEVI---------------KELYPQFSRLVKPGG 253
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
173-253 9.03e-03

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 36.82  E-value: 9.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239632 173 CREGdVRRLPfsDNYFDVVVsavflhT-----IGKEYGQKTVEAAAER---------MRVLGEAVRVLKPGGVGVVW-DL 237
Cdd:COG0863   7 CLEV-LKELP--DESVDLIV------TdppynLGKKYGLGRREIGNELsfeeyleflREWLAECYRVLKPGGSLYVNiGD 77

                        90
                ....*....|....*.
gi 15239632 238 VHVPEYVRRLQELRME 253
Cdd:COG0863  78 RYISRLIAALRDAGFK 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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