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Conserved domains on  [gi|15239705|ref|NP_199691|]
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Phototropic-responsive NPH3 family protein [Arabidopsis thaliana]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 13605777)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) and NPH3 domain-containing protein may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 219-459 1.80e-107

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


:

Pssm-ID: 460777  Cd Length: 218  Bit Score: 322.52  E-value: 1.80e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705   219 DWWIEDLSVLRIDLYQRVMNAMKCRGVRPESIGASLVSYAEREL----------TKRSEHE----QTIVETIVTLLPVEN 284
Cdd:pfam03000   1 DWWFEDLSELSIDLFKRVISAMKSKGMKPEVIGEALMHYAKKWLpglsrsssssASRSEDDnskqRELLETIVSLLPSEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705   285 LVVPISFLFGLLRRAVILDTSVSCRLDLERRLGSQLDMATLDDLLIPSFRHAGdTLFDIDTvhrilvnfsqqggddsede 364
Cdd:pfam03000  81 GSVSCSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSGEE-TLYDVDL------------------- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705   365 esvfecdsphspsqtamfKVAKLVDSYLAEIAPDANLDLSKFLLIAEALPPHARTLHDGLYRAIDLYLKAHQGLSDSDKK 444
Cdd:pfam03000 141 ------------------KVAKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERK 202

                         250
                  ....*....|....*
gi 15239705   445 KLSKLIDFQKLSQEA 459
Cdd:pfam03000 203 RLCRLMDCQKLSLEA 217
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 40-138 2.09e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18312:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 105  Bit Score: 131.68  E-value: 2.09e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705  40 DVPSDITIEVNGGNFALHKFPLVSRSGRIRRIVAEHRDSDISKVELLNLPGGAETFELAAKFCYGINFEITSSNVAQLFC 119
Cdd:cd18312   7 GEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSSSESDPSEIELNDFPGGAEAFELVAKFCYGMPINLTATNVVGLRC 86

                        90
                ....*....|....*....
gi 15239705 120 VSDYLEMTEEYSKDNLASR 138
Cdd:cd18312  87 AAEYLEMTESGNLGNLIDK 105
 
Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 219-459 1.80e-107

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


Pssm-ID: 460777  Cd Length: 218  Bit Score: 322.52  E-value: 1.80e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705   219 DWWIEDLSVLRIDLYQRVMNAMKCRGVRPESIGASLVSYAEREL----------TKRSEHE----QTIVETIVTLLPVEN 284
Cdd:pfam03000   1 DWWFEDLSELSIDLFKRVISAMKSKGMKPEVIGEALMHYAKKWLpglsrsssssASRSEDDnskqRELLETIVSLLPSEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705   285 LVVPISFLFGLLRRAVILDTSVSCRLDLERRLGSQLDMATLDDLLIPSFRHAGdTLFDIDTvhrilvnfsqqggddsede 364
Cdd:pfam03000  81 GSVSCSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSGEE-TLYDVDL------------------- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705   365 esvfecdsphspsqtamfKVAKLVDSYLAEIAPDANLDLSKFLLIAEALPPHARTLHDGLYRAIDLYLKAHQGLSDSDKK 444
Cdd:pfam03000 141 ------------------KVAKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERK 202

                         250
                  ....*....|....*
gi 15239705   445 KLSKLIDFQKLSQEA 459
Cdd:pfam03000 203 RLCRLMDCQKLSLEA 217
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 40-138 2.09e-36

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 131.68  E-value: 2.09e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705  40 DVPSDITIEVNGGNFALHKFPLVSRSGRIRRIVAEHRDSDISKVELLNLPGGAETFELAAKFCYGINFEITSSNVAQLFC 119
Cdd:cd18312   7 GEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSSSESDPSEIELNDFPGGAEAFELVAKFCYGMPINLTATNVVGLRC 86

                        90
                ....*....|....*....
gi 15239705 120 VSDYLEMTEEYSKDNLASR 138
Cdd:cd18312  87 AAEYLEMTESGNLGNLIDK 105
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 44-128 3.04e-03

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 37.29  E-value: 3.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705     44 DITIEVNGGNFALHKFPLVSRSGRIRRIVAEHRDSDISKVELLNlPGGAETFELAAKFCYGINFEITSSNVAQLFCVSDY 123
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLD-DVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79


                   ....*
gi 15239705    124 LEMTE 128
Cdd:smart00225  80 LQIPG 84
 
Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 219-459 1.80e-107

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


Pssm-ID: 460777  Cd Length: 218  Bit Score: 322.52  E-value: 1.80e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705   219 DWWIEDLSVLRIDLYQRVMNAMKCRGVRPESIGASLVSYAEREL----------TKRSEHE----QTIVETIVTLLPVEN 284
Cdd:pfam03000   1 DWWFEDLSELSIDLFKRVISAMKSKGMKPEVIGEALMHYAKKWLpglsrsssssASRSEDDnskqRELLETIVSLLPSEK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705   285 LVVPISFLFGLLRRAVILDTSVSCRLDLERRLGSQLDMATLDDLLIPSFRHAGdTLFDIDTvhrilvnfsqqggddsede 364
Cdd:pfam03000  81 GSVSCSFLLGLLRTAIILGASEACREELERRIGLQLEQATLDDLLIPSYSGEE-TLYDVDL------------------- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705   365 esvfecdsphspsqtamfKVAKLVDSYLAEIAPDANLDLSKFLLIAEALPPHARTLHDGLYRAIDLYLKAHQGLSDSDKK 444
Cdd:pfam03000 141 ------------------KVAKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLYRAIDIYLKAHPGLSESERK 202

                         250
                  ....*....|....*
gi 15239705   445 KLSKLIDFQKLSQEA 459
Cdd:pfam03000 203 RLCRLMDCQKLSLEA 217
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 40-138 2.09e-36

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 131.68  E-value: 2.09e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705  40 DVPSDITIEVNGGNFALHKFPLVSRSGRIRRIVAEHRDSDISKVELLNLPGGAETFELAAKFCYGINFEITSSNVAQLFC 119
Cdd:cd18312   7 GEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSSSESDPSEIELNDFPGGAEAFELVAKFCYGMPINLTATNVVGLRC 86

                        90
                ....*....|....*....
gi 15239705 120 VSDYLEMTEEYSKDNLASR 138
Cdd:cd18312  87 AAEYLEMTESGNLGNLIDK 105
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-124 1.05e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 49.47  E-value: 1.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705  43 SDITIEVNGGNFALHKFPLVSRSGRIRRI-VAEHRDSDISKVELLNLPggAETFELAAKFCYGINFEITSSNVAQLFCVS 121
Cdd:cd18186   2 CDVTLVVGGREFPAHRAVLAARSPYFRAMfSSGMKESSSSEIELDDVS--PEAFEALLDYIYTGELELSEENVEELLAAA 79


                ...
gi 15239705 122 DYL 124
Cdd:cd18186  80 DKL 82
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-158 1.65e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 39.21  E-value: 1.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705  43 SDITIEVNGGNFALHKFPLVSRSGRIRRI-VAEHRDSDISKVELLNLpgGAETFELAAKFCYGINFEITSSNVAQLFCVS 121
Cdd:cd18270  27 TDIVLIVEGTEFPCHKMVLATCSSYFRAMfMSGLSESKQTHVHLRNV--DAATLQIIITYAYTGNLAINDSTVEQLYETA 104

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15239705 122 DYLEMteeyskDNLASRTEEYLESIVckNLEMCVQVL 158
Cdd:cd18270 105 CFLQV------EDVLQRCREYLIKKI--NAENCVRLL 133
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-128 1.98e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 38.40  E-value: 1.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705  44 DITIEVNGGNFALHKFPLVSRSGRIRRIVAEHRDSDISKVELLNLPGGA-ETFELAAKFCYGINFEITSSNVAQLFCVSD 122
Cdd:cd18201  23 DVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTTVTHLDVVAvQGFSVILDFMYSGNLVLTSQNAIEVMSVAS 102


                ....*.
gi 15239705 123 YLEMTE 128
Cdd:cd18201 103 YLQMTE 108
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 44-128 3.04e-03

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 37.29  E-value: 3.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705     44 DITIEVNGGNFALHKFPLVSRSGRIRRIVAEHRDSDISKVELLNlPGGAETFELAAKFCYGINFEITSSNVAQLFCVSDY 123
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLD-DVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79


                   ....*
gi 15239705    124 LEMTE 128
Cdd:smart00225  80 LQIPG 84
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 43-124 6.60e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 37.07  E-value: 6.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15239705  43 SDITIEVNGGNFALHKFPLVSRSGRIRRIVAEH-RDSDISKVELLNLpgGAETFELAAKFCYGINFEITSSNVAQLFCVS 121
Cdd:cd18352  14 SDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGyREKEARDIEIPNI--RWEVFELMMRFIYTGSVDITNDIAKDLLRAA 91


                ....
gi 15239705 122 D-YL 124
Cdd:cd18352  92 DqYL 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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