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Conserved domains on  [gi|22327597|ref|NP_199364|]
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Leucine-rich repeat (LRR) family protein [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
595-914 5.54e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.07  E-value: 5.54e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  595 IKTVQAKKGDKITTILVSGDRLRRVTPKKFFKNLKELEVLGLFEPtvkpfvpSFSDQLKLLRVLIIRDCDLLKSIEELKA 674
Cdd:COG4886   62 LSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELAN 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  675 LTKLNTLEVSGaSSLSKISEKFFeSFPELRSLHLSGLKIESSPPSISGLKELHCLIIKDCPlLQDLPN-IQELVNLEVVD 753
Cdd:COG4886  135 LTNLKELDLSN-NQLTDLPEPLG-NLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEpLGNLTNLEELD 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  754 VSGA--SGLRTCFDNadgakknksknknfylLTKLQHLDFSGSQIERLPIFqdsavaAKLHSLTRLLLRNCsKLRRLPSL 831
Cdd:COG4886  212 LSGNqlTDLPEPLAN----------------LTNLETLDLSNNQLTDLPEL------GNLTNLEELDLSNN-QLTDLPPL 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  832 KPLSGLQILDLSGTTSLVEMLEVCFEDKLELKTLNLSGTNLSELATTIEDLSSLNELLLRDCINLDAIPNIEKLENLEVI 911
Cdd:COG4886  269 ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLA 348


                 ...
gi 22327597  912 DVS 914
Cdd:COG4886  349 LLT 351
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
595-914 5.54e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.07  E-value: 5.54e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  595 IKTVQAKKGDKITTILVSGDRLRRVTPKKFFKNLKELEVLGLFEPtvkpfvpSFSDQLKLLRVLIIRDCDLLKSIEELKA 674
Cdd:COG4886   62 LSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELAN 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  675 LTKLNTLEVSGaSSLSKISEKFFeSFPELRSLHLSGLKIESSPPSISGLKELHCLIIKDCPlLQDLPN-IQELVNLEVVD 753
Cdd:COG4886  135 LTNLKELDLSN-NQLTDLPEPLG-NLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEpLGNLTNLEELD 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  754 VSGA--SGLRTCFDNadgakknksknknfylLTKLQHLDFSGSQIERLPIFqdsavaAKLHSLTRLLLRNCsKLRRLPSL 831
Cdd:COG4886  212 LSGNqlTDLPEPLAN----------------LTNLETLDLSNNQLTDLPEL------GNLTNLEELDLSNN-QLTDLPPL 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  832 KPLSGLQILDLSGTTSLVEMLEVCFEDKLELKTLNLSGTNLSELATTIEDLSSLNELLLRDCINLDAIPNIEKLENLEVI 911
Cdd:COG4886  269 ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLA 348


                 ...
gi 22327597  912 DVS 914
Cdd:COG4886  349 LLT 351
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 652-921 3.22e-14

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 77.99  E-value: 3.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597   652 LKLLRVLIIRDCDLLKSIEELKALTKLNTLEVSGASSLSKISEKFfESFPELRSLHLSG-LKIESSPPSISgLKELHCLI 730
Cdd:PLN03210  633 LTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVELPSSI-QYLNKLEDLDMSRcENLEILPTGIN-LKSLYRLN 710

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597   731 IKDCPLLQDLPNIQelVNLEVVDVSGA------SGLRtcFDNADGAKKNKSKNKNFY--------LLTKLQH----LDFS 792
Cdd:PLN03210  711 LSGCSRLKSFPDIS--TNISWLDLDETaieefpSNLR--LENLDELILCEMKSEKLWervqpltpLMTMLSPsltrLFLS 786

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597   793 G--SQIERLPIFQDsavaakLHSLTRLLLRNCSKLRRLPSLKPLSGLQILDLSGTTSLVemlevCFED-KLELKTLNLSG 869
Cdd:PLN03210  787 DipSLVELPSSIQN------LHKLEHLEIENCINLETLPTGINLESLESLDLSGCSRLR-----TFPDiSTNISDLNLSR 855

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 22327597   870 TNLSELATTIEDLSSLNELLLRDCINLDAI-PNIEKLENLEVIDVSGSAKLAK 921
Cdd:PLN03210  856 TGIEEVPWWIEKFSNLSFLDMNGCNNLQRVsLNISKLKHLETVDFSDCGALTE 908
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 783-939 1.41e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 1.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  783 LTKLQHLDFSGSQIERLPIFQdsavaaKLHSLTRL-LLRNCskLRRLPSLKPLSGLQILDLSGTtSLVEMLEVCFEDKL- 860
Cdd:cd21340   45 LTNLTHLYLQNNQIEKIENLE------NLVNLKKLyLGGNR--ISVVEGLENLTNLEELHIENQ-RLPPGEKLTFDPRSl 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  861 -----ELKTLNLSGTNLSELAttiedlsslnelllrdcinldaipNIEKLENLEVIDVSGS--AKLAKIEGSFEKMFYLR 933
Cdd:cd21340  116 aalsnSLRVLNISGNNIDSLE------------------------PLAPLRNLEQLDASNNqiSDLEELLDLLSSWPSLR 171


                 ....*.
gi 22327597  934 VVDLSG 939
Cdd:cd21340  172 ELDLTG 177
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
595-914 5.54e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.07  E-value: 5.54e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  595 IKTVQAKKGDKITTILVSGDRLRRVTPKKFFKNLKELEVLGLFEPtvkpfvpSFSDQLKLLRVLIIRDCDLLKSIEELKA 674
Cdd:COG4886   62 LSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELAN 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  675 LTKLNTLEVSGaSSLSKISEKFFeSFPELRSLHLSGLKIESSPPSISGLKELHCLIIKDCPlLQDLPN-IQELVNLEVVD 753
Cdd:COG4886  135 LTNLKELDLSN-NQLTDLPEPLG-NLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEpLGNLTNLEELD 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  754 VSGA--SGLRTCFDNadgakknksknknfylLTKLQHLDFSGSQIERLPIFqdsavaAKLHSLTRLLLRNCsKLRRLPSL 831
Cdd:COG4886  212 LSGNqlTDLPEPLAN----------------LTNLETLDLSNNQLTDLPEL------GNLTNLEELDLSNN-QLTDLPPL 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  832 KPLSGLQILDLSGTTSLVEMLEVCFEDKLELKTLNLSGTNLSELATTIEDLSSLNELLLRDCINLDAIPNIEKLENLEVI 911
Cdd:COG4886  269 ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLA 348


                 ...
gi 22327597  912 DVS 914
Cdd:COG4886  349 LLT 351
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
652-915 8.31e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 8.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  652 LKLLRVLIIRDCDLLKSIEELKALTKLNTLEVSGASSLSKisekffesFPELRSLHLSGLKIESSPPSISGLKELHCLII 731
Cdd:COG4886   72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSN--------LTNLESLDLSGNQLTDLPEELANLTNLKELDL 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  732 KDCPlLQDLPNiqELVNlevvdvsgasglrtcfdnadgakknksknknfylLTKLQHLDFSGSQIERLPifqdsAVAAKL 811
Cdd:COG4886  144 SNNQ-LTDLPE--PLGN----------------------------------LTNLKSLDLSNNQLTDLP-----EELGNL 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  812 HSLTRLLLRNCsKLRRLP-SLKPLSGLQILDLSGT--TSLVEMLEVCfedkLELKTLNLSGTNLSELAtTIEDLSSLNEL 888
Cdd:COG4886  182 TNLKELDLSNN-QITDLPePLGNLTNLEELDLSGNqlTDLPEPLANL----TNLETLDLSNNQLTDLP-ELGNLTNLEEL 255

                        250       260
                 ....*....|....*....|....*..
gi 22327597  889 LLRDCiNLDAIPNIEKLENLEVIDVSG 915
Cdd:COG4886  256 DLSNN-QLTDLPPLANLTNLKTLDLSN 281
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 652-921 3.22e-14

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 77.99  E-value: 3.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597   652 LKLLRVLIIRDCDLLKSIEELKALTKLNTLEVSGASSLSKISEKFfESFPELRSLHLSG-LKIESSPPSISgLKELHCLI 730
Cdd:PLN03210  633 LTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVELPSSI-QYLNKLEDLDMSRcENLEILPTGIN-LKSLYRLN 710

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597   731 IKDCPLLQDLPNIQelVNLEVVDVSGA------SGLRtcFDNADGAKKNKSKNKNFY--------LLTKLQH----LDFS 792
Cdd:PLN03210  711 LSGCSRLKSFPDIS--TNISWLDLDETaieefpSNLR--LENLDELILCEMKSEKLWervqpltpLMTMLSPsltrLFLS 786

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597   793 G--SQIERLPIFQDsavaakLHSLTRLLLRNCSKLRRLPSLKPLSGLQILDLSGTTSLVemlevCFED-KLELKTLNLSG 869
Cdd:PLN03210  787 DipSLVELPSSIQN------LHKLEHLEIENCINLETLPTGINLESLESLDLSGCSRLR-----TFPDiSTNISDLNLSR 855

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 22327597   870 TNLSELATTIEDLSSLNELLLRDCINLDAI-PNIEKLENLEVIDVSGSAKLAK 921
Cdd:PLN03210  856 TGIEEVPWWIEKFSNLSFLDMNGCNNLQRVsLNISKLKHLETVDFSDCGALTE 908
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
623-912 1.16e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 1.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  623 KFFKNLKELEVLGLFEPTVKPFVPSFSdQLKLLRVLIIRDCDLlKSI-EELKALTKLNTLEVSGaSSLSKISEkFFESFP 701
Cdd:COG4886  130 EELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQL-TDLpEELGNLTNLKELDLSN-NQITDLPE-PLGNLT 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  702 ELRSLHLSGLKIESSPPSISGLKELHCLIIKDCPLlQDLPNIQELVNLEVVDVSG--ASGLRTCFDnadgakknksknkn 779
Cdd:COG4886  206 NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL-TDLPELGNLTNLEELDLSNnqLTDLPPLAN-------------- 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  780 fylLTKLQHLDFSGSQIERLPIFQDSAVAAKLHSLTRLLLRNCSKLRRLPSLKPLSGLQILDLSGTTSLVEMLEVCFEDK 859
Cdd:COG4886  271 ---LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 22327597  860 LELKTLNLSGTNLSELATTIEDLSSLNELLLRDCINLDAIPNIEKLENLEVID 912
Cdd:COG4886  348 ALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGV 400
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
809-950 1.60e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 1.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  809 AKLHSLTRLLLRNCsklrrlPSLKPLSGLQILDLSGT--TSLVEMLEvcfedKL-ELKTLNLSGTNLSELATTIEDLSSL 885
Cdd:COG4886   93 GDLTNLTELDLSGN------EELSNLTNLESLDLSGNqlTDLPEELA-----NLtNLKELDLSNNQLTDLPEPLGNLTNL 161

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22327597  886 NELLLRDCiNLDAIPN-IEKLENLEVIDVSGSaKLAKIEGSFEKMFYLRVVDLSGTQVEtpELPAD 950
Cdd:COG4886  162 KSLDLSNN-QLTDLPEeLGNLTNLKELDLSNN-QITDLPEPLGNLTNLEELDLSGNQLT--DLPEP 223
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 694-919 2.33e-07

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 55.27  E-value: 2.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597   694 EKFFE---SFPELRSLHLSGLKIESSPPSISGLKELHCLIIKDCPLLQDLP-NIQELVNLEVVDVSGASGLrtcfdnadg 769
Cdd:PLN03210  624 EKLWDgvhSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKLSDCSSLVELPsSIQYLNKLEDLDMSRCENL--------- 694

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597   770 akknksknknfylltklqhldfsgsqiERLPIfqdsavAAKLHSLTRLLLRNCSKLRRLPSLKplSGLQILDLSGTT--- 846
Cdd:PLN03210  695 ---------------------------EILPT------GINLKSLYRLNLSGCSRLKSFPDIS--TNISWLDLDETAiee 739

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597   847 -------------SLVEMLEVCFEDKLELKT------------LNLSGT-NLSELATTIEDLSSLNELLLRDCINLDAIP 900
Cdd:PLN03210  740 fpsnlrlenldelILCEMKSEKLWERVQPLTplmtmlspsltrLFLSDIpSLVELPSSIQNLHKLEHLEIENCINLETLP 819

                         250
                  ....*....|....*....
gi 22327597   901 NIEKLENLEVIDVSGSAKL 919
Cdd:PLN03210  820 TGINLESLESLDLSGCSRL 838
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 645-915 2.38e-05

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 48.72  E-value: 2.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597   645 VPSFSDQLKLLRVLIIRDCDLL--KSIEELKALTKLNTLEvsgASSLSKIsekFFESFPELRSLhlsglkiessPPSISG 722
Cdd:PLN03210  737 IEEFPSNLRLENLDELILCEMKseKLWERVQPLTPLMTML---SPSLTRL---FLSDIPSLVEL----------PSSIQN 800

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597   723 LKELHCLIIKDCPLLQDLPNIQELVNLEVVDVSGASGLRTCFDnadgakknksknknfyLLTKLQHLDFSGSQIERLPIF 802
Cdd:PLN03210  801 LHKLEHLEIENCINLETLPTGINLESLESLDLSGCSRLRTFPD----------------ISTNISDLNLSRTGIEEVPWW 864

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597   803 QDsavaaKLHSLTRLLLRNCSKLRRL-PSLKPLSGLQILDLSGTTSLVEMlevcfedklelkTLNLSGTNLSELATTIED 881
Cdd:PLN03210  865 IE-----KFSNLSFLDMNGCNNLQRVsLNISKLKHLETVDFSDCGALTEA------------SWNGSPSEVAMATDNIHS 927

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 22327597   882 -LSSLNELLLRDCINLDAIPNIEKLENLEVIDVSG 915
Cdd:PLN03210  928 kLPSTVCINFINCFNLDQEALLQQQSIFKQLILSG 962
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 783-939 1.41e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 1.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  783 LTKLQHLDFSGSQIERLPIFQdsavaaKLHSLTRL-LLRNCskLRRLPSLKPLSGLQILDLSGTtSLVEMLEVCFEDKL- 860
Cdd:cd21340   45 LTNLTHLYLQNNQIEKIENLE------NLVNLKKLyLGGNR--ISVVEGLENLTNLEELHIENQ-RLPPGEKLTFDPRSl 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  861 -----ELKTLNLSGTNLSELAttiedlsslnelllrdcinldaipNIEKLENLEVIDVSGS--AKLAKIEGSFEKMFYLR 933
Cdd:cd21340  116 aalsnSLRVLNISGNNIDSLE------------------------PLAPLRNLEQLDASNNqiSDLEELLDLLSSWPSLR 171


                 ....*.
gi 22327597  934 VVDLSG 939
Cdd:cd21340  172 ELDLTG 177
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 666-817 5.69e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 5.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  666 LKSIEELKALTKLNTLEVSGaSSLSKISEkfFESFPELRSLHLS------GLKIESSPPSISGLKE-LHCLIIKDCPLlQ 738
Cdd:cd21340   58 IEKIENLENLVNLKKLYLGG-NRISVVEG--LENLTNLEELHIEnqrlppGEKLTFDPRSLAALSNsLRVLNISGNNI-D 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22327597  739 DLPNIQELVNLEVVDVSgasglRTCFDNADgakknkSKNKNFYLLTKLQHLDFSGSQIERLPIFQDSAVAAKlHSLTRL 817
Cdd:cd21340  134 SLEPLAPLRNLEQLDAS-----NNQISDLE------ELLDLLSSWPSLRELDLTGNPVCKKPKYRDKIILAS-KSLEVL 200
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
813-944 9.47e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 9.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22327597  813 SLTRLLLRNCSKLRRLPSLKPLSGLQILDLSGTTSLVEMLEVCFEDKLELKTLNLSGTNLSELATTIEDLSSLNELLLRD 892
Cdd:COG4886   26 LLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSG 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 22327597  893 CinldaiPNIEKLENLEVIDVSGSaKLAKIEGSFEKMFYLRVVDLSGTQVET 944
Cdd:COG4886  106 N------EELSNLTNLESLDLSGN-QLTDLPEELANLTNLKELDLSNNQLTD 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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