|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
40-476 |
1.53e-158 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 457.03 E-value: 1.53e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 40 ETKKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNVIIGFNYSLFIGMATALETLCGQAFGAKKYDMFG 119
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 120 VYLQRSWIVLFLFSILLLPMYIFATPILKFMGQPDDIAELSGIISVWAIPTHFSFAFFFPINRFLQCQLKNSVIAISSGV 199
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 200 SLVVHIFVCWLFVYVLELGVIGTIATANVSWWLNVFILFTYTTC-GGCPLTWTGFSMESFTRLWEFTKLSASSGIMVCLE 278
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFsKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 279 NWYYRMLIVMTGNLEdARIDVDSMSICMSINGLEMMVPLAFFAGTSVRVANELGAGNGKRARFAMIISVTQSLIIGIIIS 358
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 359 VLIYFLLDQIGWMFSSSETVLKAVNNLSILLSFAILLNSVQPVLSGVAVGSGWQSLVAFINLGCYYFIGLPLGIVMGWMF 438
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399
|
410 420 430
....*....|....*....|....*....|....*...
gi 15240080 439 KFGVKGIWAGMIFgGTMVQTLILIFITMRCDWEKEAQN 476
Cdd:cd13132 400 GLGLKGLWIGLIA-GLILQAVILLLIILRTDWDKEAEK 436
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
41-452 |
4.99e-48 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 171.10 E-value: 4.99e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 41 TKKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNvIIGFNYSLFIGMATALETLCGQAFGAKKYDMFGV 120
Cdd:COG0534 7 LKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFP-IFFLLIALGIGLGVGGTALVAQALGAGDREEARR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 121 YLQRSWIVLFLFSILL-LPMYIFATPILKFMGQPDDIAELSGIISVWAIPTHFSFAFFFPINRFLQCQLKNSVIAISSGV 199
Cdd:COG0534 86 VLGQALLLALLLGLLLtLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 200 SLVVHIFVCWLFVYVLELGVIGT-IATAnVSWWLNVFILFTYTTCGGCPLTWTGFSME-SFTRLWEFTKLSASSGIMVCL 277
Cdd:COG0534 166 GNVLNIVLDPLLIFGGGLGVAGAaLATV-ISQAVSALLLLYYLFRKRSLLRLRLRDLRpDRKILKRILRIGLPAGLQQLA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 278 ENWYYRMLIVMTGNLEDAriDVDSMSICMSINGLEMMVPLAFFAGTSVRVANELGAGNGKRARFAMIISVTQSLIIGIII 357
Cdd:COG0534 245 ESLGFLVLNALVARLGTA--AVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 358 SVLIYFLLDQIGWMFSSSETVLKAVNNLSILLSFAILLNSVQPVLSGVAVGSGWQSLVAFINLGCYYFIGLPLGIVMGWM 437
Cdd:COG0534 323 ALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAFL 402
|
410
....*....|....*
gi 15240080 438 FkFGVKGIWAGMIFG 452
Cdd:COG0534 403 G-LGLTGVWLALPIG 416
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
50-390 |
8.77e-44 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 157.41 E-value: 8.77e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 50 PAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNVIiGFNYSLFIGMATALETLCGQAFGAKKYDMFGVYLQRSWIVL 129
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVF-MFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 130 FLFSILLLPM-YIFATPILKFMGQPDDIAELSGIISVWAIPTHFSFAFFFPINRFLQCQLKNSVIAISSGVSLVVHIFVC 208
Cdd:TIGR00797 80 LLLGLPVLLVgYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 209 WLFVYVL--ELGVIGTiATANV-SWWLNVFILFTYTTCGG-CPLTWTGFSMESFTRLWEFTKLSASSGIMVCLENWYYRM 284
Cdd:TIGR00797 160 YILIFGKfgFLGIVGA-ALATViSYWLMFLLLLYYIKKAKkIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 285 LIVMTGNLEDarIDVDSMSICMSINGLEMMVPLAFFAGTSVRVANELGAGNGKRARFAMIISVTQSLIIGIIISVLIYFL 364
Cdd:TIGR00797 239 LALLVARLGS--IALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILF 316
|
330 340
....*....|....*....|....*.
gi 15240080 365 LDQIGWMFSSSETVLKAVNNLSILLS 390
Cdd:TIGR00797 317 REFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
40-468 |
2.83e-38 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 144.56 E-value: 2.83e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 40 ETKKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNVIIGFnYSLFIGMATALETLCGQAFGAKKYDMFG 119
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPV-FTFGMGLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 120 VYLQRSWIVLFLFSILLLPMYIFATPILKFMGQPDDIAELSG---IISVWAIPthfSFAFFFPINRFLQCQLKNSVIAIS 196
Cdd:cd13131 80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARgylLALAWGIP---PALLFQVLRSFLDALGRTRPAMVI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 197 SGVSLVVHIFVCWLFVY----VLELGVIGT-IATANVSWwLNVFILFTYTTCG---GCPLTWTGFSMESFTRLWEFTKLS 268
Cdd:cd13131 157 TLLALVLNIPLNYVLIFgkfgLPALGGAGAgLATAIVYW-LMFLALAFYIRRHkrfRRYRLFARFWRPDWARLKELLRLG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 269 ASSGIMVCLENWYYRMLIVMTGNLEDarIDVDSMSICMSINGLEMMVPLAFFAGTSVRVANELGAGNGKRARFAMIISVT 348
Cdd:cd13131 236 LPIGLTIFFEVSLFAAVALLMGRLGT--TVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 349 QSLIIGIIISVLIYFLLDQIGWMFSSSETVLKAVNNLSILLSFAILLNSVQPVLSGVAVGSGWQSLVAFINLGCYYFIGL 428
Cdd:cd13131 314 LGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGL 393
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 15240080 429 PLGIVMGWMFKFGVKGIWAGMIFGGTMVQTLILIFITMRC 468
Cdd:cd13131 394 PLGYLLAFTTGLGAFGVWIGLIIGLALAAILLLWRFRRLQ 433
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
42-470 |
1.02e-32 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 129.17 E-value: 1.02e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 42 KKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNVIIGFnYSLFIGMATALETLCGQAFGAKKYDMFGVY 121
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLL-LVLNMALGTGTVALVSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 122 LQRSWIVLFLFSILL-LPMYIFATPILKFMGQPDDIAELSGI---ISVWAIPThfsFAFFFPINRFLQCQlKNSVIA-IS 196
Cdd:cd13137 80 LGQSLLLALLLSLPLaLLGLLFAEPLLRLLGADPEVIALALTylrIVLLGIPF---FFLSLVGNAALRGA-GDTKTPmYI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 197 SGVSLVVHIFVCWLFVYVL----ELGV----IGTIATANVSWWLNVFILFTYTTCGGCPLTWTGFSMESFTRLWeftKLS 268
Cdd:cd13137 156 MIIVNVLNIVLDYVLIFGLwgfpGLGVagaaLATVISRVVGALLLLFLLLRGRLPIKISFKGFRLDRKIIKKLL---RIG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 269 ASSGIMVCLENWYYRMLIVMTGNLEDarIDVDSMSICMSINGLEMMVPLAFFAGTSVRVANELGAGNGKRARFAMIISVT 348
Cdd:cd13137 233 LPAGLEQLLRSLGFLVLLAIVASYGT--AALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALR 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 349 QSLIIGIIISVLIYFLLDQIGWMFSSSETVLKAVNNLSILLSFAILLNSVQPVLSGVAVGSGWQSLVAFINLGCYYFIGL 428
Cdd:cd13137 311 LGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRL 390
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 15240080 429 PLGIVMGWMFKFGVKGIWAGMIFgGTMVQTLILIFITMRCDW 470
Cdd:cd13137 391 PLAYLLGFVLGLGLTGIWLAMFV-DTIVRAILLLYRFRKGKW 431
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
50-210 |
5.71e-29 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 111.89 E-value: 5.71e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 50 PAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNvIIGFNYSLFIGMATALETLCGQAFGAKKYDMFGVYLQRSWIVL 129
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANS-IASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 130 FLFSILL-LPMYIFATPILKFMGQPDDIAELSGIISVWAIPTHFSFAFFFPINRFLQCQLKNSVIAISSGVSLVVHIFVC 208
Cdd:pfam01554 80 LLLSLPIaLLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 15240080 209 WL 210
Cdd:pfam01554 160 YL 161
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
49-464 |
4.06e-25 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 107.41 E-value: 4.06e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 49 GPAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNVIIGFnYSLFIGMATALETLCGQAFGAKKYDMFGVYLQRSWIV 128
Cdd:cd12082 2 APLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALL-IALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 129 LFLFSILLLPMYIFATP-ILKFMGQPDDIAELSGIISVWAIPTHFSFAFFFPINRFLQCQLKNSVIAISSGVSLVVHIFV 207
Cdd:cd12082 81 AILLGLLLAALLLFFSPlILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 208 CWLFVY---VLELGVIG-TIATAnVSWWLNVFILFTYTTCGGcplTWTGFSMESFTRLWEFT----KLSASSGIMVCLEN 279
Cdd:cd12082 161 DPLLIFglgPPELGIAGaALATV-ISYVIGALLLLIYLRKGK---KILKFKLSLLKPDLELLrrllRIGLPSAIQNSLLS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 280 WYYRMLIVMTGNLEDARiDVDSMSICMSINGLEMMVPLAFFAGTSVRVANELGAGNGKRARFAMIISVTQSLIIGIIISV 359
Cdd:cd12082 237 LGLLIIVAIVAAFGGAA-ALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 360 LIYFLLDQIGWMFSSSETVLKAVNNLSILLSFAILLNSVQPVLSGVAVGSGWQSLVAFINLGCYYFIGLPLGIVMGWMFk 439
Cdd:cd12082 316 LILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLG- 394
|
410 420
....*....|....*....|....*
gi 15240080 440 FGVKGIWAGMIFGGTMVQTLILIFI 464
Cdd:cd12082 395 LGLYGIWLALVISLILAALVLLLFF 419
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
67-471 |
5.73e-23 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 101.00 E-value: 5.73e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 67 AFAGH-LGELELAAISIVNNVIIGFNySLFIGMATALETLCGQAFGAKKYDMFGVYLQRSWIVLFLFSILLLP-MYIFAT 144
Cdd:cd13138 28 LIVGQfLGVAALAAVSNGSPIIFLLT-AIGMGLSMGGTILISQYIGAKDEEKAKKAVGTLLVLFLILGIVLTIlGLLFAP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 145 PILKFMGQPDDIAELSGI---ISVWAIPthFSFAFFFpINRFLQCQLKNSVIAISSGVSLVVHIFVCWLFVYVLELGVIG 221
Cdd:cd13138 107 PILRLMNTPAEILELAVSylrICFLGIP--FIFGYNA-YSAILRGLGDSKTPLYFVIIACVLNIILDLLFIAVFHMGVAG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 222 T-IATAnVSWWLNVFILFTYTTCGGCPLTWTGFSME-SFTRLWEFTKLSASSGIMVCLENwyYRMLIVMTGNLEDARIDV 299
Cdd:cd13138 184 AaLATV-IAQAISVLLALYYLRKKKLPFKLSLKDFRfDKEILKEILKIGLPSALQQSLVS--ISFLIINSIVNSYGVVAS 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 300 DSMSICMSINGLEMMVPLAFFAGTSVRVANELGAGNGKRARFAMIISVTQSLIIGIIISVLIYFLLDQIGWMFSSSETVL 379
Cdd:cd13138 261 AAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVI 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 380 KAVNNLSILLSFAILLNSVQPVLSGVAVGSGWQSLVAFINLGCYYFIGLPLGIVMGWMFKFGVKGIWAGMIFgGTMVQTL 459
Cdd:cd13138 341 EIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLSRLTGLGLFGIWLAMPI-SNILSAI 419
|
410
....*....|..
gi 15240080 460 ILIFITMRCDWE 471
Cdd:cd13138 420 ICIIYYRKGRWK 431
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
40-452 |
1.97e-22 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 99.50 E-value: 1.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 40 ETKKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNVIIGFnYSLFIGMATALETLCGQAFGAKKYDMFG 119
Cdd:PRK01766 10 EARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIWLPV-ILFGHGLLLALTPIVAQLNGAGRRERIA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 120 -VYLQRSWIVLFLFSILLLPMYIFATPILKFMGQPDDIAE-----LSGIIsvWAIPthfsfAFFFPINrfLQCQL----K 189
Cdd:PRK01766 89 hQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADiavgyLHALL--WGIP-----AYLLYQV--LRSFIdglgK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 190 NSVIAISSGVSLVVHIFVCWLFVY----VLELGVIGT-IATANVsWWLNVFILFTYT-------TCGgcplTWTGFSMES 257
Cdd:PRK01766 160 TKPTMVIGFLGLLINIPLNYIFIYgkfgFPELGGVGCgVATAIV-YWVMFLAMLIYIkrarrfrDFR----LFKGLYKPD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 258 FTRLWEFTKLSASSGIMVCLENWYYRMLIVMTGNLEDarIDVDSMSICMSINGLEMMVPLAFFAGTSVRVANELGAGNGK 337
Cdd:PRK01766 235 WAVIKRLLKLGLPIGLAIFFEVSLFAVVTLLVSPLGT--VTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 338 RARFAMIISVTQSLIIGIIISVLIYFLLDQIGWMFSSSETVLKAVNNLSILLSFAILLNSVQPVLSGVAVGSGWQSLVAF 417
Cdd:PRK01766 313 DARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIFF 392
|
410 420 430
....*....|....*....|....*....|....*
gi 15240080 418 INLGCYYFIGLPLGIVMGWMFKFGVKGIWAGMIFG 452
Cdd:PRK01766 393 ITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIG 427
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
41-451 |
9.03e-22 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 97.60 E-value: 9.03e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 41 TKKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNVIIGFnYSLFIGMATALETLCGQAFGAKKYDMFGV 120
Cdd:cd13133 4 YREILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFAI-LMLFFGLSSGVQVFVAQYNGAGRYSRIGR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 121 YLQRSWIVLFLFSILLLPMYIFATP-ILKFMGQPDDIAELSGIISVWAIPTHFSFAFFFPINRFLQCQLKNSVIAISSGV 199
Cdd:cd13133 83 VLWQGLYFSLLLAPLLALLSALAAPlLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 200 SLVVHIFVCWLFVY----VLELGVIGT-IATAnVSWWLNVFILFTYTTCGGCP-----LTWTGFSMESFTRLWeftKLSA 269
Cdd:cd13133 163 MVVVNIVLDYALIFgklgFPAMGIAGAaIATV-IAEAVSLLFFLLLLFRRKNRrrfglRRAWRFDRELLRRIL---RLGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 270 SSGIMVCLENWYYRMLIVMTGNLEDARIDVdsMSICMSINGLEMMVPLAFFAGTSVRVANELGAGNGKRARFAMIISVTQ 349
Cdd:cd13133 239 PSGLQFFLDVGAFTVFFLLIGRLGTTELAA--TNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 350 SLIIGIIISVLIYFLLDQIGWMFS---SSETVLKAVNNLSILLSFAILLNSVQPVLSGVAVGSGWQSLVAFINLGCYYFI 426
Cdd:cd13133 317 ALAYMLLLGILFLLFPELLLSIFTpgaDFALIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLY 396
|
410 420
....*....|....*....|....*
gi 15240080 427 GLPLGIVMGWmFKFGVKGIWAGMIF 451
Cdd:cd13133 397 LLPPAYLLVV-LGAGLAGAWTVETV 420
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
42-467 |
5.02e-19 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 89.11 E-value: 5.02e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 42 KKLWRIVGPAIFTRVTTNLIFVITQAFAGHL-GELELAAISIVN---NVIIGFnySLFIGMATAleTLCGQAFGAKKYDM 117
Cdd:cd13143 4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFpiiMLLMAL--GLMIGVGGA--SLISRRLGAGDREK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 118 FGVYLQRSWIVLFLFSILL-LPMYIFATPILKFMGQPDDIAELS---GIISVWAIPthFSFAFFFpINRFLQCQLKNSVI 193
Cdd:cd13143 80 ANRIFSTALLLSLILGLLLtILGLLFLDPLLRLLGASGELLPYAvdyLRIILLGAP--FTILSSV-LNNLLRAEGKPKLA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 194 AISSGVSLVVHIFVCWLFVYVLELGVIGT-IATAnVSWWLNVFILFTYTTCGGCPLTWT-GFSMESFTRLWEFTKLSASS 271
Cdd:cd13143 157 MLGMLIGAVLNIILDPLFIFVLGLGIAGAaLATV-IAQLISLLLLLLYFFRGKSLLKLSlLRFKLSLKIIKEILALGFPS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 272 GIMvclenWYYRMLIVMTGNLEDAR----IDVDSMSICMSINGLEMMVPLAFFAGTSVRVANELGAGNGKRARFAMIISV 347
Cdd:cd13143 236 FLM-----QLSSSVVTIVLNLTLLGyggdIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLAL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 348 TQSLIIGIIISVLIYFLLDQIGWMFSSSETVLKAVNNLSILLSFAILLNSVQPVLSGVAVGSGWQSLVAFINLGCYYFIG 427
Cdd:cd13143 311 IVALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFL 390
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 15240080 428 LPLGIVMGWMfkFGVKGIWagMIFGGTMVQTLILIFITMR 467
Cdd:cd13143 391 IPLLLILPRL--FGLDGIW--LAFPLAEILTLLLALILLK 426
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
41-451 |
6.67e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 85.63 E-value: 6.67e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 41 TKKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNvIIGFNYSLFIGMATALETLCGQAFGAKKYDMFGV 120
Cdd:cd13134 2 KLSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQ-ILFLLILIFSFISTGTSILIAQYLGAKDKKKARQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 121 YLQRSWIVLFLFSILL-LPMYIFATPILKFMGQPDDIAELSG----IISVWAIPTHFSFAFFFpinrFLQCQLKNSVIAI 195
Cdd:cd13134 81 IAGVALLFNLLLGLVFsLLLLFFGAELLRLMGLPPELLALGStylrIVGGSLFLQALSLTLSA----ILRSHGRTKIPMY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 196 SSGVSLVVHIFVCWLFVYVL----ELGVIG-TIATAnVSWWLNVFILFTYTtcgGCPLTWTGFSMESFTRLWEFTKLSAS 270
Cdd:cd13134 157 VSLIMNILNIVGNYLLIFGWfglpKLGVAGvAISTV-ISRAVGLVLLFILL---FRKLKIRFRLKDLRPFPKKLLKKILK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 271 SGIMVCLENWYYRM-LIVMTGNLedARIDVDSM---SICMSINGLEMMVPLAFFAGTSVRVANELGAGNGKRA------- 339
Cdd:cd13134 233 IGLPSAGEELSYNLsQTVITAFI--ARLGTAALaarTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAykrvlks 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 340 -RFAMIISVTqsliigiiISVLIYFLLDQIGWMFSSSETVLKAVNNL---SILLSFAILLNSVqpvLSGVAVGSGWQSLV 415
Cdd:cd13134 311 lKIGLLVSLA--------VALLLALFREPILGLFTDDPEIIALGKTLlliSILLEPGRAFNIV---LIGSLRAAGDARFP 379
|
410 420 430
....*....|....*....|....*....|....*.
gi 15240080 416 AFINLGCYYFIGLPLGIVMGWMFKFGVKGIWAGMIF 451
Cdd:cd13134 380 VLIGIISMWGISVPLAYLLGIVLGLGLLGVWIAFAA 415
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
271-437 |
2.01e-17 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 79.53 E-value: 2.01e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 271 SGIMVCLENWYYRMLIVMTGNLEDarIDVDSMSICMSINGLEMMVPLAFFAGTSVRVANELGAGNGKRARFAMIISVTQS 350
Cdd:pfam01554 2 IALENLLQSLYSLIDTLFVGHLGA--VALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 351 LIIGIIISVLIYFLLDQIGWMFSSSETVLKAVNNLSILLSFAILLNSVQPVLSGVAVGSGWQSLVAFINlgcyyFIGLPL 430
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYIN-----IISLLL 154
|
....*..
gi 15240080 431 GIVMGWM 437
Cdd:pfam01554 155 NIPLNYL 161
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
38-240 |
2.92e-17 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 83.65 E-value: 2.92e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 38 WLETKKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNvIIGFNYSLFIGMATALETLCGQAFGAKKYDM 117
Cdd:COG0534 225 RKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALR-IESLAFMPALGLGQAAQPLVGQNLGAGDYDR 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 118 FGVYLQRSWIVLFLFSILL-LPMYIFATPILKFMGQPDDIAELSGIISVWAIPTHFSFAFFFPINRFLQCQLKNSVIAIS 196
Cdd:COG0534 304 ARRAARLALLLALGIGLLLaLLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMII 383
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 15240080 197 SGVSLVVHIFVCWLFVYVLELGVIGTIATANVSWWLNVFILFTY 240
Cdd:COG0534 384 SLLRLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
70-472 |
2.88e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 77.62 E-value: 2.88e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 70 GHLGELELAAISIVNNVIIGFnYSLFIGMATALETLCGQAFGAKKYDMFGVYLQRSWIVLFLFSILL-LPMYIFATPIL- 147
Cdd:cd13142 39 GRLGADAVAAPSISWPLIFLF-ISLGGGLTVAGTALVAQYTGAGDYDKANKVAGQTFSFVIILSLILaVLGYILSRPLLl 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 148 KFMGQPDDIAELSGI---ISVWAIPthfsFAFFFPINRFLQCQLKNSVI-AISSGVSLVVHIFVCWLFVY----VLELGV 219
Cdd:cd13142 118 LLIGAPEEVYPLALAylrIIFLGLP----FMFIFFVFNSLLRGIGDTKTpMKIMFGSVLLNVILDPLLIFgigpFPGLGV 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 220 IG----TIATANVSWWLNVFILFTYTTcgGCPLTWTGFSMEsftrlWEFTKLSASSGIMVCLEnWYYRML--IVMTGNLE 293
Cdd:cd13142 194 AGaalaTVISRGIAAVIGLYLLFKGRV--GLKISLRDLKPD-----WEWLKKIFRIGLPSSIE-QSARALgfTVMTALVA 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 294 DARIDVDS-MSICMSINGLEMMVPLAFFAGTSVRVANELGAGNGKRARFAMIISVTQSLIIGIIISVLIYFLLDQIGWMF 372
Cdd:cd13142 266 GFGTVVVAaYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLILVIGGVLAFLFAEPIVRVF 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 373 SSSETVLKAVNNLSILLSFAILLNSVQPVLSGVAVGSGWQSLVAFINLGCYYFIGLPLGIVMGWMFKFGVKGIWAGMIFG 452
Cdd:cd13142 346 INDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPLAYLLAYVLGLGVTGIWIAMAIS 425
|
410 420
....*....|....*....|
gi 15240080 453 GTMVQTLILIFITmRCDWEK 472
Cdd:cd13142 426 NIVAALIALAWFK-RGTWKK 444
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
42-240 |
8.78e-11 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 63.63 E-value: 8.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 42 KKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNvIIGFNYSLFIGMATALETLCGQAFGAKKYDMFGVY 121
Cdd:cd13138 225 KEILKIGLPSALQQSLVSISFLIINSIVNSYGVVASAAYGIANK-INSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKG 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 122 LQRSWIVLFLFSILL-LPMYIFATPILKFMGQPDDIAELSGIISVWAIPTHFSFAFFFPINRFLQ-CQLKNSVIAISSGV 199
Cdd:cd13138 304 LRTGIIISLIIGLIIiLLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRgLGKTKFPMIISILR 383
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 15240080 200 SLVVHIFVCWLFVYVLELGVIGTIATANVSWWLNVFILFTY 240
Cdd:cd13138 384 LWLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIY 424
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
42-451 |
1.37e-10 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 62.96 E-value: 1.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 42 KKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGEL-ELAAISiVNNVIIGFNYSL--FIGMATAleTLCGQAFGAKKYD-M 117
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHLGSAaYLGAVA-LGTTIFNTLFWLfgFLRMGTT--GLVAQALGAGDREeA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 118 FGVYLQRSWIVLFLFSILLLPMYIFATPILKFMGQPDDIAELSGI---ISVWAIPTHF-SFAFffpiNRFLQCQLKNSVI 193
Cdd:cd13136 80 IALLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQylrIRILGAPAVLlNYVA----TGWFRGLQDTRTP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 194 AISSGVSLVVHIFVCWLFVYVLELGVIGtIATANV-----SWWLNVFILFTYTTCGGCPLTWTGFSMESFTRLweftkLS 268
Cdd:cd13136 156 LILQIVGNVVNIVLDPLFVFGLGWGVAG-AALATViaqylGALLGLWLLRRRVRLLGKSLSRRLPSKAALKRL-----FK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 269 ASSGIMVclenwyyRMLIVMTGNL----EDARIDVDSMS---ICMSINGLEMMVPLAFFAGTSVRVANELGAGNGKRARF 341
Cdd:cd13136 230 LNRDIFI-------RTLALLAAFLfftaLAARLGDVILAanqILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARR 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 342 AMIISVTQSLIIGIIISVLIYFLLDQIGWMFSSSETVLKAVNNLSILLSFAILLNSVQPVLSGVAVGSGW------QSLV 415
Cdd:cd13136 303 VARRLLQWGLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDtrylrnSMLV 382
|
410 420 430
....*....|....*....|....*....|....*.
gi 15240080 416 AFInlgcyyfIGLPLGIVMGWMfkFGVKGIWAGMIF 451
Cdd:cd13136 383 SLA-------VFLPLLFLLVPL--WGNHGLWLALIL 409
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
37-221 |
8.10e-10 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 60.60 E-value: 8.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 37 IWLETKKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNvIIGFNYSLFIGMATALETLCGQAFGAKKYD 116
Cdd:cd13137 221 DRKIIKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLR-IESLAFMPGFGFSMAASTLVGQNLGAGDPD 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 117 MFGVYLQRSWIVLFLF-SILLLPMYIFATPILKFMGQPDDIAELSGIISVWAIPTHFSFAFFFPINRFLQCQLKNSVIAI 195
Cdd:cd13137 300 EARRYGKRALRLGVLFmGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLI 379
|
170 180
....*....|....*....|....*..
gi 15240080 196 SSGVSL-VVHIFVCWLFVYVLELGVIG 221
Cdd:cd13137 380 INLISMwLVRLPLAYLLGFVLGLGLTG 406
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
34-168 |
1.43e-07 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 53.40 E-value: 1.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 34 KKEIWLETKKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNViIGFNYSLFIGMATALETLCGQAFGAK 113
Cdd:TIGR00797 208 LKPDWEVLKRLLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNV-ESLLFMPAFGFGIAVSILVGQALGAG 286
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 15240080 114 KYDMFGVYLQRSWIVLFLFSILL-LPMYIFATPILKFMGQPDDIAELSGIISVWAI 168
Cdd:TIGR00797 287 DPKRAKEVARVALKLSLLLGLVLaIILILFREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
38-159 |
1.29e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 50.60 E-value: 1.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 38 WLETKKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNViigfnYSLF----IGMATALETLCGQAFGAK 113
Cdd:cd13133 227 RELLRRILRLGLPSGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSI-----NSLAflpmIGLGIAVSSLVGQALGAG 301
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 15240080 114 KYDMFGVYLQRS-WIVLFLFSILLLPMYIFATPILKFMGQPDDIAEL 159
Cdd:cd13133 302 RPDLAMRVTRRGlKLALAYMLLLGILFLLFPELLLSIFTPGADFALI 348
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
42-228 |
1.93e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 50.27 E-value: 1.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 42 KKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNvIIGFNYSLFIGMATALETLCGQAFGAKKYDMFGVY 121
Cdd:cd13142 237 KKIFRIGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNR-IISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEI 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 122 LQRS-WIVLFLFSILLLPMYIFATPILK-FMGQPDDIAELSGIISVWAiPTHFSFAFFFPINRFLQCQLKNSVIAISSGV 199
Cdd:cd13142 316 VKKAaLLIFLILVIGGVLAFLFAEPIVRvFINDPEVIKEGADFLRIVA-PSFPFFGLFQVINGAFRGSGHTLTAMIISIL 394
|
170 180 190
....*....|....*....|....*....|...
gi 15240080 200 SL-VVHIFVCWLFVYVLELGVIG---TIATANV 228
Cdd:cd13142 395 RLwVIRIPLAYLLAYVLGLGVTGiwiAMAISNI 427
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
96-239 |
2.78e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 49.52 E-value: 2.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 96 IGMATALETLCGQAFGAKKYDMFGVYLQRSWIVLFLFSILL-LPMYIFATPILKFMGQ-PDDIAELSGIISVWAIpTHFS 173
Cdd:cd13145 287 IGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVAtVFLLFFAEPLMSLFTNdPAVIAIGAGYLRIDAL-IFYA 365
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15240080 174 FAFFFPINRFLQcQLKNSVIAISSGVS--LVVHIFVCWLFVYVLELGVIG---TIATANVSWWLnVFILFT 239
Cdd:cd13145 366 YVVLFISVSVLQ-GLKRPIFALWIGLYrqLVGPALVFWLLVNVLGLGVTGiwwGIFTIVWSAAI-IALLYT 434
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
42-238 |
2.86e-06 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 49.76 E-value: 2.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 42 KKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGElelAAISIVN--NVIIGFNYSLF-IGMATALETLCGQAFGAKKYDMF 118
Cdd:COG0728 222 RRVLKLMLPALLGVSVSQINLLVDTILASFLPE---GSVSALYyaDRLYQLPLGLFgVAIGTALLPRLSRAAAAGDLEEF 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 119 GVYLQRSWIVLFLFSILL-LPMYIFATPILKFMGQ-----PDDIAELSGIISVWAIpTHFSFAFFFPINRFLQCQLKNSV 192
Cdd:COG0728 299 RRTLSRGLRLVLLLTLPAaVGLIVLAEPIVRLLFErgaftAEDTALTALALAAYAL-GLPAFALVKVLARAFYARQDTRT 377
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 15240080 193 IAISSGVSLVVHIFVCWLFVYVleLGVIG-TIATAnVSWWLNVFILF 238
Cdd:COG0728 378 PVRIAVIAVVVNIVLNLLLVPP--LGHAGlALATS-LSALVNALLLL 421
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
50-446 |
3.04e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 49.53 E-value: 3.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 50 PAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNVIIgFNYSLFIGMATALETLCGQAFGAKKYDMFGVYLQRSWIVL 129
Cdd:cd13139 22 PMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLT-IVYSIAIGLSMAATALVARRIGEKDPEGAGFAAVQAILLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 130 FLFSILL-LPMYIFATPILKFMGQPDDIAELSGIISVWAIPTHFSFAFFFPINRFLQcQLKNSVIAISS-GVSLVVHIFV 207
Cdd:cd13139 101 VALSLILsILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFR-GAGDAAIAMRSlWLANGLNIIL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 208 CWLFVYVL----ELGVIGTIATANVSWWLNVFILFTYTTCGGcplTWTGFSMESFTRLWEFTK------LSASSGIMVCL 277
Cdd:cd13139 180 DPLFIFGLgpipAMGVTGAAIATTIGRSIGVLYQLYHLFKGK---GRIQIRRRHLKLDWAIIKkiikiaVGGILQFLIAS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 278 ENWYYRMLIVMtgnlEDARIDVDSMSICMSINGLEMMVPLAFFAGTSVRVANELGAGNGKRARFAMIISVTQSLIIGIII 357
Cdd:cd13139 257 SSWIFLVRIIA----EFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNMVFLGIV 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 358 SVLIYFLLDQIGWMFSSSETVLK-AVNNLSIlLSFAILLNSVQPVLSGVAVGSGWQSLVAFINLGCYYFIGLPLGIVMGW 436
Cdd:cd13139 333 SLVFFLFAEPLVSFFTTDPEVIAiAVEALRI-ISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIPLAYLLAR 411
|
410
....*....|
gi 15240080 437 MFKFGVKGIW 446
Cdd:cd13139 412 HLNLGPKGVF 421
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
38-217 |
3.70e-06 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 49.10 E-value: 3.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 38 WLETKKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNVIIGFNYSLFiGMATALETLCGQAFGAKKYDM 117
Cdd:cd13136 221 KAALKRLFKLNRDIFIRTLALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLD-GFAYAAEALVGRALGAGDRKA 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 118 FGVYLQRSWIVLFLFSILL-LPMYIFATPILKFMGQPDDIAELSGIISVWAIPTHF--SFAF-----FFPINRFlqcqlk 189
Cdd:cd13136 300 ARRVARRLLQWGLGLGVLLaLLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPigALAFvldgiFIGATDT------ 373
|
170 180
....*....|....*....|....*...
gi 15240080 190 nSVIAISSGVSLVVHIFVCWLFVYVLEL 217
Cdd:cd13136 374 -RYLRNSMLVSLAVFLPLLFLLVPLWGN 400
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
42-238 |
2.35e-05 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 46.68 E-value: 2.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 42 KKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGElelAAISIVN--NVIIGFNYSLF-IGMATALETLCGQAFGAKKYDMF 118
Cdd:cd13123 215 RRVLKLMLPALLGVSVSQINLLVDTILASFLPE---GSISALYyaDRLYQLPLGIFgVAIATALLPRLSRLAAAGDLDEF 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 119 GVYLQRSWIVLFLfsiLLLP----MYIFATPILKFMGQ-----PDDIAELSGIISVWAIPThFSFAFFFPINRFLQCQLK 189
Cdd:cd13123 292 RRTLSRGLRLVLF---LLLPaavgLIVLAEPIVRLLFErgaftAEDTLMTASALAAYALGL-PAFALVKLLSRAFYALKD 367
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 15240080 190 NSVIAISSGVSLVVHIFVCWLFVYVleLGVIGtIATAN-VSWWLNVFILF 238
Cdd:cd13123 368 TKTPVKIAVIAVAVNILLNLLLIKP--LGHVG-LALATsLSAWVNALLLL 414
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
66-449 |
9.82e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 44.82 E-value: 9.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 66 QAFAGHLGELELAAISiVNNVIIGFNYSLFIGMATALETLCGQAFGAKKYDMFGVYLQRSWIVLFLFSILL-LPMYIFAT 144
Cdd:cd13140 29 MFWVGRLGSDAVAAVG-TAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEARKYARNALQLNLLLGILYgLLLLLFAK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 145 PILKFMGQPDDIAELSGI----ISVWAIPthfsFAFFFPINRFLQCQLKNSVIA-ISSGVSLVVHIFVCWLFVYVL---- 215
Cdd:cd13140 108 PLIGFFNLGDAEVISLAItylrIVALGLI----FSFLNPVFTGIFNALGDSKTPfIINAIGLVLNIILDPLLIFGFgpfp 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 216 ELGVIGTiATANVSWWLNVFILFTYTTCG--GCPLTWTGFSMESFTRLWEFTKLSASSGIMVCLENWYYRMLIVMTGNLE 293
Cdd:cd13140 184 ALGVAGA-ALATVLAQAIVFLLFLYALKKkkGLFLKIRILKRPDRKYIKEILKLGLPVALQSILFALISMILARIIASFG 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 294 DARIDVdsMSICMSINGLEMMVPLAFFAGTSVRVANELGAGNGKRARFAMIISVTQSLIIGIIISVLIYFLLDQIGWMFS 373
Cdd:cd13140 263 PVAIAA--QKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAIGLFATLLLFFFGEPLFSLFI 340
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15240080 374 S-SETVLKAVNNLSIlLSFAILLNSVQPVLSGVAVGSGWQSLVAFINLGCyYFIGLPLGIVMGWMfKFGVKGIWAGM 449
Cdd:cd13140 341 PdPETIAIGVDYLRI-LGFSQLFMCLEITTTGAFNGLGRTKPPAIISIVF-NGLRIPLALLLSPT-GLGLNGIWWAI 414
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
42-446 |
1.12e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 44.53 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 42 KKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGELELAAISI---VNNVIIgfnySLFIGMATALETLCGQAFGAKKYDMf 118
Cdd:cd13144 8 RLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLafpIQNLMI----AVAVGTGVGVNALLSRSLGEKDQKE- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 119 GVYLQRSWIVLFLFSILLLpmYIFATPILK--FMGQPDDIAELSGIISVWAIPTHFSFAFFFPI--NRFLQCQLKNSVIA 194
Cdd:cd13144 83 ANKAANNGLLLALLSYLLF--LLLGLFGVKpfFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQIlcEKVLQSTGNTITPM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 195 ISSGVSLVVHIFVCWLFVYVLE----LGVIGTIATANVSWWLNVFILFTYTTCGGCPLTWTGFSMESFTRLW-EFTKLSA 269
Cdd:cd13144 161 IAQLIGAIINIILDPILIFGLFgfpaMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRLFRPSLRIIkEIYAVGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 270 SSGIMVCLENwyyrmLIVMTGNLEDARIDVDSMSICMSINGLEMMVPLAFF---AGTSVRVANELGAGNGKRARFAMIIS 346
Cdd:cd13144 241 PSIIMQAISS-----VMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFglnNGLIPIVAYNYGAGNKDRIREAIKYA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 347 VTQSLIIGIIISVLIYFLLDQIGWMFSSSETVLK-AVNNLSIlLSFAILLNSVQPVLSGV--AVGSGWQSLVAFINLGCy 423
Cdd:cd13144 316 ILIAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAiGVPALRI-ISLSFLFAALSIILSGLfqALGRGVYSLIISVARQL- 393
|
410 420
....*....|....*....|...
gi 15240080 424 yFIGLPLGIVMGWMfkFGVKGIW 446
Cdd:cd13144 394 -VVLLPLAWLLAKM--FGLNGVW 413
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
304-452 |
3.64e-04 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 42.81 E-value: 3.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 304 ICMSINGLEMMVPLAFFAGTSVRVANELGAGNGKRARFAMIISVTQSLIIGIIISVLIYFLLDQIGWMF------SSSET 377
Cdd:PRK00187 276 IALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIGFGAVVMLLFAGLFWLLPEAIIGLFldrndpAFAEI 355
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15240080 378 VLKAVNNLSILLSFAiLLNSVQPVLSGVAVGSGWQSLVAFINLGCYYFIGLPLGIVMGWMFKFGVKGIWAGMIFG 452
Cdd:PRK00187 356 VQLAVSLLAVAAWFE-LFDGTQTIAMGAIRGLKDARTTFLIGLACYWLVGAPLAWLLAFTLGWGAVGVWWGLALG 429
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
77-452 |
3.86e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 42.77 E-value: 3.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 77 LAAISIVNNVIIGFnYSLFIGMATALETLCGQAFGAKKYDMFGVYLQRSWIVLFLFSIL-LLPMYIFATPILKFMGQPDD 155
Cdd:cd13146 46 VGGIGLVFPLGMIF-LALGNGIQVGVSSLLARAIGAQRAKELDQAADSGLALALLAATViVVLGYIFAEPLLQLLGAKGL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 156 IAELSGIISVWAIPTHFSFAFFFPINRFLQCQLKNSVIAISSGVSLVVHIFVCWLFVYVLELGVIGTiATANVSWWLNVF 235
Cdd:cd13146 125 LLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGA-ALATVLAQAISL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 236 ILFTYTTCGG---CPLTW--TGFSMESFTRLWEFTKLSASSGIMVCLENWYYRMLIVmtgnledaRIDVDSMS---ICMS 307
Cdd:cd13146 204 LYLLYVFLIGksnVTIHIklSNISSSVIVEILRVGLPQMLLQLISSISFLIYNRIII--------DIDPVAMTaftLVGR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 308 INGLEMMVPLAFFAGTSVRVANELGAGNGKRARFAMIISVTQSLIIGIIISVLIYFLLDQIGWMFSS-SETVLKAVNNLS 386
Cdd:cd13146 276 LDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTvPEVVAYAVLQVR 355
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15240080 387 IL-LSFAILLNSVQPVLSGVAVGSGWQSLVafINLGCYYFIGLPLGIVMGWMFKFGVKGIWAGMIFG 452
Cdd:cd13146 356 TMaLALPFVAISILVTEFFQAIGKAWPSLL--LTLIRHVFLSVPVVYLLAYVFGKGITGVYFGIVSA 420
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
42-455 |
5.06e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 42.28 E-value: 5.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 42 KKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGELELAAISIVN---NVIIGFNYSLFIGmataLETLCGQAFGAKKYDMF 118
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTtpfNTITGFLGSISIG----FTILGSQSVGAKDIKRI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 119 GVYLQRSWIVLFLFSILLLPMYIF-ATPILKFMGQPDDIAELS----GIISVWAIPTHFSFAFffpiNRFLQCQLKNSVI 193
Cdd:cd13135 77 NDYAISSIVYNSIIGVILFLLWLFgARIIFVLFGVDGQILGYSinyvRIFSIYLLLLGILFTF----SSILQGIGETKPI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 194 AISSGVSLVVHIFVCWLFVY----VLELGVIGTIATANVSWWLNVFILFTYT-TCGGCPLTWTGFSMESFT-RLWEFT-K 266
Cdd:cd13135 153 MYGGIIKNLLNVILDYVLIFgnfgFPRLGIIGAAIATTIANVLNLIILVYLCrKIKKLTFKLSNTKVLKANiRPYKFTiK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 267 LSASSGIMVCLENWYYRMLIVMTGNLEDarIDVDSMSICMSINGLEMMVPLAFFAGTSVRVANELGAGNGKRARFAMIIS 346
Cdd:cd13135 233 LGLPLGGEEFLWNIGNLAVIRILNRIGE--LALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNIC 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 347 VTQSLIIGIIISVLIYFLLDQIGWMFSSSETVLKAVNNLSILLSFAILLNSVQPVLSGVAVGSGWQSLVAFINLGCyYFI 426
Cdd:cd13135 311 LGLGLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIG-TII 389
|
410 420
....*....|....*....|....*....
gi 15240080 427 GLPLGIVMGWMFKFGVKGIWAGMIFGGTM 455
Cdd:cd13135 390 VVSVALLLIFVFKLGLAGVYITLFIDEII 418
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
68-238 |
6.31e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 39.12 E-value: 6.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 68 FAGHLGELELAAISI---VNNVIIGFNyslfIGMATALETLCGQAFGAKKYDMFGVYLQRSWIVLFLFSILL-LPMYIFA 143
Cdd:cd13145 35 FAGKISTEALAALSLsfpIFFIIIAIG----VGIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLtVIGLFAA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 144 TPILKFMGQPDDIAELSGIISVWAIPTHFSFAFFFPINRFLQCQ-----LKNSVIaissgVSLVVHIFVCWLFVY----V 214
Cdd:cd13145 111 PPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQgdtksYRNFLI-----IGFFLNIILDPLFIFggggI 185
|
170 180
....*....|....*....|....*
gi 15240080 215 LELGVIG-TIATANVSWWLNVFILF 238
Cdd:cd13145 186 PAMGVSGiALATIISQFIGMFYLLY 210
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
38-232 |
9.84e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 38.15 E-value: 9.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 38 WLETKKLWRIVGPAIFTRVTTNLIFVITQAFAGHLGELELAAISIVNNviigFNYSLFI---GMATALETLCGQAFGAKK 114
Cdd:cd13146 228 SSVIVEILRVGLPQMLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGR----LDQFILIpifAISSALLTIAGQNWGRGN 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15240080 115 YDMFGVYLQRSWIVLFLFSILLLPMYIFATP-ILKFMGQPDDIAELSGIISVWAIPTHFSFAFFFPINRFLQCQLKNSV- 192
Cdd:cd13146 304 YDRMLQILMTAVILGIVVVLVLVLGYVLVAPwLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPs 383
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 15240080 193 IAISSGVSLVVHIFVCWLFVYVLELGVIG--------TIATANVSWWL 232
Cdd:cd13146 384 LLLTLIRHVFLSVPVVYLLAYVFGKGITGvyfgivsaNFFTALLAMFW 431
|
|
| |
