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Conserved domains on  [gi|15242937|ref|NP_197661|]
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Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

Protein Classification

disease resistance family protein( domain architecture ID 1000118)

disease resistance family protein similar to Nicotiana glutinosa TMV resistance protein N; resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via a direct or indirect interaction with this avirulence protein

Gene Ontology:  GO:0006952

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN03210 super family cl33662
Resistant to P. syringae 6; Provisional
 4-992 0e+00

Resistant to P. syringae 6; Provisional


The actual alignment was detected with superfamily member PLN03210:

Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 1395.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937     4 SYRNWLYDVFPSFSGEDVRVTFLSHFLKELDRKLISVFKDNDIQRSQSLDPELKLAIRDSRIAIVVFSKNYAASSWCLDE 83
Cdd:PLN03210    7 SSRNWVYDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDNEIERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWCLNE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937    84 LLEIVKCKEEFGQIVIPVFYGLDPCHVRKQSGEFGIVFENTCQTKTDDEIQKWRRALTDVANILGFHSSNWDNEATMVED 163
Cdd:PLN03210   87 LLEIVRCKEELGQLVIPVFYGLDPSHVRKQTGDFGEAFEKTCQNKTEDEKIQWKQALTDVANILGYHSQNWPNEAKMIEE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   164 IANDVLAKLNLTTtSNDFEGFVGIEGHIAKISLMLCLECKQVRMFGIWGPSGIGKTTIARALFSRISRHFQGSVFLDRAF 243
Cdd:PLN03210  167 IANDVLGKLNLTP-SNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFIDRAF 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   244 VSKSMEIYSGGNVDNYNAKLHLQGKFLSEILRAKDIKISNLGVVGERLKHMKVLIFIDDLDDQVVLDALASKPHWFGCGS 323
Cdd:PLN03210  246 ISKSMEIYSSANPDDYNMKLHLQRAFLSEILDKKDIKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGS 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   324 RIIVITKDKQFFRAHGIGLFYEVGLPSDKLALEMFSQSAFRQNSPPPGFTELASEVSKRSGNLPLALNVLGSHLRGRDKE 403
Cdd:PLN03210  326 RIIVITKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRGRDKE 405

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   404 DWIDMLPRLRKGLDGKIEKILRVGYDELSNKDDKAIFRLIACLFNGAEISYIKLLLADSNLGVTIGLKNLVDKSLIRIGC 483
Cdd:PLN03210  406 DWMDMLPRLRNGLDGKIEKTLRVSYDGLNNKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLIHVRE 485

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   484 DTVEMHSMLQEMGREIVREQSiYEPGEREFLVDSTDILDVLNDNTGTKKVLGISFDMSEIEELHIHKRAFKRMPNLRFLR 563
Cdd:PLN03210  486 DIVEMHSLLQEMGKEIVRAQS-NEPGEREFLVDAKDICDVLEDNTGTKKVLGITLDIDEIDELHIHENAFKGMRNLLFLK 564

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   564 FYKKLGKQSKEARLHLQEGFDkFFPPKLKLLSWDDYPMRRMPSNFHAGYLVVLRMQHSKLEKLWQGVQPLTCLREMQLWG 643
Cdd:PLN03210  565 FYTKKWDQKKEVRWHLPEGFD-YLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRG 643

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   644 SKKLKEIPDLSLATNLETLYLNDCSSLVELPSSIKNLNKLWDLGMKGCEKLELLPTDINLKSLYRLDLGRCSRLKSFPDI 723
Cdd:PLN03210  644 SKNLKEIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEILPTGINLKSLYRLNLSGCSRLKSFPDI 723

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   724 SSNIS--------------------------------------------------------------------------- 728
Cdd:PLN03210  724 STNISwldldetaieefpsnlrlenldelilcemkseklwervqpltplmtmlspsltrlflsdipslvelpssiqnlhk 803

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   729 ----------------------------------------------ELYLNRTAIEEVPWWIQKFSRLKRLRMRECKKLK 762
Cdd:PLN03210  804 lehleiencinletlptginleslesldlsgcsrlrtfpdistnisDLNLSRTGIEEVPWWIEKFSNLSFLDMNGCNNLQ 883

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   763 CISPNISKLKHLEMLDFSNCIATTE------------------------------------EEALVQQQSVLKYLIFPGG 806
Cdd:PLN03210  884 RVSLNISKLKHLETVDFSDCGALTEaswngspsevamatdnihsklpstvcinfincfnldQEALLQQQSIFKQLILSGE 963

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   807 QVPLYFTYQATGSSLaIPLSLHQSSLSQQLLGFRACVVLDAESMSSELYVIDIKVCCRLSGKRSNLFDSADCRDAFFTPQ 886
Cdd:PLN03210  964 EVPSYFTHRTTGASL-TNIPLLHISPCQPFFRFRACAVVDSESFFIISVSFDIQVCCRFIDRLGNHFDSPYQPHVFSVTK 1042

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   887 MDSHLVIFDCCFPLNQDNVRLAELNNDKVVTEFHFT-SISRCKITGVGVRFLRDCSLPENHHNDPNILAPNCGCPETEHS 965
Cdd:PLN03210 1043 KGSHLVIFDCCFPLNEDNAPLAELNYDHVDIQFRLTnKNSQLKLKGCGIRLSEDDSSLNNTLPNVEEADDDNPVNGSEHW 1122

                        1130      1140
                  ....*....|....*....|....*..
gi 15242937   966 DEYGEFGVETKRSRKRKRITLRTAQET 992
Cdd:PLN03210 1123 EDCEDSALERESERTKDREMRDRLLKK 1149
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 4-992 0e+00

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 1395.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937     4 SYRNWLYDVFPSFSGEDVRVTFLSHFLKELDRKLISVFKDNDIQRSQSLDPELKLAIRDSRIAIVVFSKNYAASSWCLDE 83
Cdd:PLN03210    7 SSRNWVYDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDNEIERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWCLNE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937    84 LLEIVKCKEEFGQIVIPVFYGLDPCHVRKQSGEFGIVFENTCQTKTDDEIQKWRRALTDVANILGFHSSNWDNEATMVED 163
Cdd:PLN03210   87 LLEIVRCKEELGQLVIPVFYGLDPSHVRKQTGDFGEAFEKTCQNKTEDEKIQWKQALTDVANILGYHSQNWPNEAKMIEE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   164 IANDVLAKLNLTTtSNDFEGFVGIEGHIAKISLMLCLECKQVRMFGIWGPSGIGKTTIARALFSRISRHFQGSVFLDRAF 243
Cdd:PLN03210  167 IANDVLGKLNLTP-SNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFIDRAF 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   244 VSKSMEIYSGGNVDNYNAKLHLQGKFLSEILRAKDIKISNLGVVGERLKHMKVLIFIDDLDDQVVLDALASKPHWFGCGS 323
Cdd:PLN03210  246 ISKSMEIYSSANPDDYNMKLHLQRAFLSEILDKKDIKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGS 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   324 RIIVITKDKQFFRAHGIGLFYEVGLPSDKLALEMFSQSAFRQNSPPPGFTELASEVSKRSGNLPLALNVLGSHLRGRDKE 403
Cdd:PLN03210  326 RIIVITKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRGRDKE 405

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   404 DWIDMLPRLRKGLDGKIEKILRVGYDELSNKDDKAIFRLIACLFNGAEISYIKLLLADSNLGVTIGLKNLVDKSLIRIGC 483
Cdd:PLN03210  406 DWMDMLPRLRNGLDGKIEKTLRVSYDGLNNKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLIHVRE 485

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   484 DTVEMHSMLQEMGREIVREQSiYEPGEREFLVDSTDILDVLNDNTGTKKVLGISFDMSEIEELHIHKRAFKRMPNLRFLR 563
Cdd:PLN03210  486 DIVEMHSLLQEMGKEIVRAQS-NEPGEREFLVDAKDICDVLEDNTGTKKVLGITLDIDEIDELHIHENAFKGMRNLLFLK 564

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   564 FYKKLGKQSKEARLHLQEGFDkFFPPKLKLLSWDDYPMRRMPSNFHAGYLVVLRMQHSKLEKLWQGVQPLTCLREMQLWG 643
Cdd:PLN03210  565 FYTKKWDQKKEVRWHLPEGFD-YLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRG 643

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   644 SKKLKEIPDLSLATNLETLYLNDCSSLVELPSSIKNLNKLWDLGMKGCEKLELLPTDINLKSLYRLDLGRCSRLKSFPDI 723
Cdd:PLN03210  644 SKNLKEIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEILPTGINLKSLYRLNLSGCSRLKSFPDI 723

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   724 SSNIS--------------------------------------------------------------------------- 728
Cdd:PLN03210  724 STNISwldldetaieefpsnlrlenldelilcemkseklwervqpltplmtmlspsltrlflsdipslvelpssiqnlhk 803

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   729 ----------------------------------------------ELYLNRTAIEEVPWWIQKFSRLKRLRMRECKKLK 762
Cdd:PLN03210  804 lehleiencinletlptginleslesldlsgcsrlrtfpdistnisDLNLSRTGIEEVPWWIEKFSNLSFLDMNGCNNLQ 883

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   763 CISPNISKLKHLEMLDFSNCIATTE------------------------------------EEALVQQQSVLKYLIFPGG 806
Cdd:PLN03210  884 RVSLNISKLKHLETVDFSDCGALTEaswngspsevamatdnihsklpstvcinfincfnldQEALLQQQSIFKQLILSGE 963

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   807 QVPLYFTYQATGSSLaIPLSLHQSSLSQQLLGFRACVVLDAESMSSELYVIDIKVCCRLSGKRSNLFDSADCRDAFFTPQ 886
Cdd:PLN03210  964 EVPSYFTHRTTGASL-TNIPLLHISPCQPFFRFRACAVVDSESFFIISVSFDIQVCCRFIDRLGNHFDSPYQPHVFSVTK 1042

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   887 MDSHLVIFDCCFPLNQDNVRLAELNNDKVVTEFHFT-SISRCKITGVGVRFLRDCSLPENHHNDPNILAPNCGCPETEHS 965
Cdd:PLN03210 1043 KGSHLVIFDCCFPLNEDNAPLAELNYDHVDIQFRLTnKNSQLKLKGCGIRLSEDDSSLNNTLPNVEEADDDNPVNGSEHW 1122

                        1130      1140
                  ....*....|....*....|....*..
gi 15242937   966 DEYGEFGVETKRSRKRKRITLRTAQET 992
Cdd:PLN03210 1123 EDCEDSALERESERTKDREMRDRLLKK 1149
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 10-175 9.23e-65

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 215.69  E-value: 9.23e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937     10 YDVFPSFSGEDVRVTFLSHFLKELDRKLISVFKD-NDIQRSQSLDPELKLAIRDSRIAIVVFSKNYAASSWCLDELLEIV 88
Cdd:pfam01582    1 YDVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDdRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937     89 KCKEEFGQIVIPVFYGLDPCHVRKQSGEFGIVFENTCQTKTDDEIQKWRRALTDVANIlgFHSSNWDNEATMVEDIANDV 168
Cdd:pfam01582   81 ECALDLGQKVIPIFYEVDPSDVRKQTGSFGKAFKKHKKVLTEEKVLKWRGALNEVANI--WHSKSVSDESKFWKKIAYDI 158


                   ....*..
gi 15242937    169 LAKLNLT 175
Cdd:pfam01582  159 SNKLNGT 165
TIR smart00255
Toll - interleukin 1 - resistance;
10-146 2.51e-40

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 145.54  E-value: 2.51e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937      10 YDVFPSFSG-EDVRVTFLSHFLKELDRKLISVFKDNDIQRSQSLDpELKLAIRDSRIAIVVFSKNYAASSWCLDELLEIV 88
Cdd:smart00255    2 YDVFISYSGkEDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLE-EIDEAIEKSRIAIVVLSPNYAESEWCLDELVAAL 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937      89 KCKEEFGQI-VIPVFYGLDPCHVRKQSGEFGIVFENTCQTKTDDEI-QKWRRALTDVANI 146
Cdd:smart00255   81 ENALEEGGLrVIPIFYEVIPSDVRKQPGKFRKVFKKNYLKWPEDEKeQFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
628-781 5.18e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 5.18e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937  628 QGVQPLTCLREMQLWGSKkLKEIPD-LSLATNLETLYLNDCSsLVELPSSIKNLNKLWDLGMKGCeKLELLPTDI-NLKS 705
Cdd:COG4886  107 EELSNLTNLESLDLSGNQ-LTDLPEeLANLTNLKELDLSNNQ-LTDLPEPLGNLTNLKSLDLSNN-QLTDLPEELgNLTN 183

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15242937  706 LYRLDLGRCsRLKSFPD-IS--SNISELYLNRTAIEEVPWWIQKFSRLKRLRMRECkKLKCIsPNISKLKHLEMLDFSN 781
Cdd:COG4886  184 LKELDLSNN-QITDLPEpLGnlTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN-QLTDL-PELGNLTNLEELDLSN 259
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 4-992 0e+00

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 1395.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937     4 SYRNWLYDVFPSFSGEDVRVTFLSHFLKELDRKLISVFKDNDIQRSQSLDPELKLAIRDSRIAIVVFSKNYAASSWCLDE 83
Cdd:PLN03210    7 SSRNWVYDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDNEIERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWCLNE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937    84 LLEIVKCKEEFGQIVIPVFYGLDPCHVRKQSGEFGIVFENTCQTKTDDEIQKWRRALTDVANILGFHSSNWDNEATMVED 163
Cdd:PLN03210   87 LLEIVRCKEELGQLVIPVFYGLDPSHVRKQTGDFGEAFEKTCQNKTEDEKIQWKQALTDVANILGYHSQNWPNEAKMIEE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   164 IANDVLAKLNLTTtSNDFEGFVGIEGHIAKISLMLCLECKQVRMFGIWGPSGIGKTTIARALFSRISRHFQGSVFLDRAF 243
Cdd:PLN03210  167 IANDVLGKLNLTP-SNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFIDRAF 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   244 VSKSMEIYSGGNVDNYNAKLHLQGKFLSEILRAKDIKISNLGVVGERLKHMKVLIFIDDLDDQVVLDALASKPHWFGCGS 323
Cdd:PLN03210  246 ISKSMEIYSSANPDDYNMKLHLQRAFLSEILDKKDIKIYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGS 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   324 RIIVITKDKQFFRAHGIGLFYEVGLPSDKLALEMFSQSAFRQNSPPPGFTELASEVSKRSGNLPLALNVLGSHLRGRDKE 403
Cdd:PLN03210  326 RIIVITKDKHFLRAHGIDHIYEVCLPSNELALEMFCRSAFKKNSPPDGFMELASEVALRAGNLPLGLNVLGSYLRGRDKE 405

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   404 DWIDMLPRLRKGLDGKIEKILRVGYDELSNKDDKAIFRLIACLFNGAEISYIKLLLADSNLGVTIGLKNLVDKSLIRIGC 483
Cdd:PLN03210  406 DWMDMLPRLRNGLDGKIEKTLRVSYDGLNNKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLIHVRE 485

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   484 DTVEMHSMLQEMGREIVREQSiYEPGEREFLVDSTDILDVLNDNTGTKKVLGISFDMSEIEELHIHKRAFKRMPNLRFLR 563
Cdd:PLN03210  486 DIVEMHSLLQEMGKEIVRAQS-NEPGEREFLVDAKDICDVLEDNTGTKKVLGITLDIDEIDELHIHENAFKGMRNLLFLK 564

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   564 FYKKLGKQSKEARLHLQEGFDkFFPPKLKLLSWDDYPMRRMPSNFHAGYLVVLRMQHSKLEKLWQGVQPLTCLREMQLWG 643
Cdd:PLN03210  565 FYTKKWDQKKEVRWHLPEGFD-YLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRG 643

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   644 SKKLKEIPDLSLATNLETLYLNDCSSLVELPSSIKNLNKLWDLGMKGCEKLELLPTDINLKSLYRLDLGRCSRLKSFPDI 723
Cdd:PLN03210  644 SKNLKEIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEILPTGINLKSLYRLNLSGCSRLKSFPDI 723

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   724 SSNIS--------------------------------------------------------------------------- 728
Cdd:PLN03210  724 STNISwldldetaieefpsnlrlenldelilcemkseklwervqpltplmtmlspsltrlflsdipslvelpssiqnlhk 803

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   729 ----------------------------------------------ELYLNRTAIEEVPWWIQKFSRLKRLRMRECKKLK 762
Cdd:PLN03210  804 lehleiencinletlptginleslesldlsgcsrlrtfpdistnisDLNLSRTGIEEVPWWIEKFSNLSFLDMNGCNNLQ 883

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   763 CISPNISKLKHLEMLDFSNCIATTE------------------------------------EEALVQQQSVLKYLIFPGG 806
Cdd:PLN03210  884 RVSLNISKLKHLETVDFSDCGALTEaswngspsevamatdnihsklpstvcinfincfnldQEALLQQQSIFKQLILSGE 963

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   807 QVPLYFTYQATGSSLaIPLSLHQSSLSQQLLGFRACVVLDAESMSSELYVIDIKVCCRLSGKRSNLFDSADCRDAFFTPQ 886
Cdd:PLN03210  964 EVPSYFTHRTTGASL-TNIPLLHISPCQPFFRFRACAVVDSESFFIISVSFDIQVCCRFIDRLGNHFDSPYQPHVFSVTK 1042

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   887 MDSHLVIFDCCFPLNQDNVRLAELNNDKVVTEFHFT-SISRCKITGVGVRFLRDCSLPENHHNDPNILAPNCGCPETEHS 965
Cdd:PLN03210 1043 KGSHLVIFDCCFPLNEDNAPLAELNYDHVDIQFRLTnKNSQLKLKGCGIRLSEDDSSLNNTLPNVEEADDDNPVNGSEHW 1122

                        1130      1140
                  ....*....|....*....|....*..
gi 15242937   966 DEYGEFGVETKRSRKRKRITLRTAQET 992
Cdd:PLN03210 1123 EDCEDSALERESERTKDREMRDRLLKK 1149
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 10-175 9.23e-65

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 215.69  E-value: 9.23e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937     10 YDVFPSFSGEDVRVTFLSHFLKELDRKLISVFKD-NDIQRSQSLDPELKLAIRDSRIAIVVFSKNYAASSWCLDELLEIV 88
Cdd:pfam01582    1 YDVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDdRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937     89 KCKEEFGQIVIPVFYGLDPCHVRKQSGEFGIVFENTCQTKTDDEIQKWRRALTDVANIlgFHSSNWDNEATMVEDIANDV 168
Cdd:pfam01582   81 ECALDLGQKVIPIFYEVDPSDVRKQTGSFGKAFKKHKKVLTEEKVLKWRGALNEVANI--WHSKSVSDESKFWKKIAYDI 158


                   ....*..
gi 15242937    169 LAKLNLT 175
Cdd:pfam01582  159 SNKLNGT 165
TIR smart00255
Toll - interleukin 1 - resistance;
10-146 2.51e-40

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 145.54  E-value: 2.51e-40
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937      10 YDVFPSFSG-EDVRVTFLSHFLKELDRKLISVFKDNDIQRSQSLDpELKLAIRDSRIAIVVFSKNYAASSWCLDELLEIV 88
Cdd:smart00255    2 YDVFISYSGkEDVRNEFLSHLLEKLRGYGLCVFIDDFEPGGGDLE-EIDEAIEKSRIAIVVLSPNYAESEWCLDELVAAL 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937      89 KCKEEFGQI-VIPVFYGLDPCHVRKQSGEFGIVFENTCQTKTDDEI-QKWRRALTDVANI 146
Cdd:smart00255   81 ENALEEGGLrVIPIFYEVIPSDVRKQPGKFRKVFKKNYLKWPEDEKeQFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
628-781 5.18e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 5.18e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937  628 QGVQPLTCLREMQLWGSKkLKEIPD-LSLATNLETLYLNDCSsLVELPSSIKNLNKLWDLGMKGCeKLELLPTDI-NLKS 705
Cdd:COG4886  107 EELSNLTNLESLDLSGNQ-LTDLPEeLANLTNLKELDLSNNQ-LTDLPEPLGNLTNLKSLDLSNN-QLTDLPEELgNLTN 183

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15242937  706 LYRLDLGRCsRLKSFPD-IS--SNISELYLNRTAIEEVPWWIQKFSRLKRLRMRECkKLKCIsPNISKLKHLEMLDFSN 781
Cdd:COG4886  184 LKELDLSNN-QITDLPEpLGnlTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN-QLTDL-PELGNLTNLEELDLSN 259
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
621-782 1.51e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.81  E-value: 1.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937  621 SKLEKLWQGVQPLTCLREMQLWGSKKLKEIPDLSLATNLETLYLNDCSsLVELPSSIKNLNKLWDLGMKGCeKLELLPTD 700
Cdd:COG4886   77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQ-LTDLPEELANLTNLKELDLSNN-QLTDLPEP 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937  701 I-NLKSLYRLDLGRCsRLKSFPDISSNIS---ELYLNRTAIEEVPWWIQKFSRLKRLRMRECKkLKCISPNISKLKHLEM 776
Cdd:COG4886  155 LgNLTNLKSLDLSNN-QLTDLPEELGNLTnlkELDLSNNQITDLPEPLGNLTNLEELDLSGNQ-LTDLPEPLANLTNLET 232


                 ....*.
gi 15242937  777 LDFSNC 782
Cdd:COG4886  233 LDLSNN 238
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 12-109 2.57e-11

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 61.56  E-value: 2.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937     12 VFPSFSGEDVRvtFLSHFLKELDRKLISVFKD-NDIQRSQSLDPELKLAIRDSRIAIVVFSKNYAASSWCLDElLEIVKC 90
Cdd:pfam13676    1 VFISYAGEDRA--WAEWLADALEAAGYRVWLDrWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAE-WEAALA 77

                           90
                   ....*....|....*....
gi 15242937     91 KEEFGQIVIPVFYGLDPCH 109
Cdd:pfam13676   78 DPEGRKRLIPVRLECDLEL 96
PLN03194 PLN03194
putative disease resistance protein; Provisional
 11-172 1.46e-10

putative disease resistance protein; Provisional


Pssm-ID: 215626 [Multi-domain]  Cd Length: 187  Bit Score: 61.38  E-value: 1.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937    11 DVFPSFSGEDVRVTFLSHFLKELDRKLISVFKDNdiqrsQSLDPELKL------AIRDSRIAIVVFSKNYAASSWCLDEL 84
Cdd:PLN03194   28 DVFINHRGIDTKRTIATLLYDHLSRLNLRPFLDN-----KNMKPGDKLfdkinsAIRNCKVGVAVFSPRYCESYFCLHEL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937    85 LEIVKCKEEfgqiVIPVFYGLDPCHVRkqsgefgIVFENTCqtkTDDEIQKWRRALTDVANILG--FHSS--NWDNEATM 160
Cdd:PLN03194  103 ALIMESKKR----VIPIFCDVKPSQLR-------VVDNGTC---PDEEIRRFNWALEEAKYTVGltFDSLkgNWSEVVTM 168

                         170
                  ....*....|..
gi 15242937   161 VEDIANDVLAKL 172
Cdd:PLN03194  169 ASDAVIKNLIEL 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
641-782 1.08e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.79  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937  641 LWGSKKLKEIPDLSLATNLETLYLNDCSSLVELPSSIKNLNKLWDLGMKGCEKLEllptdiNLKSLYRLDLGRCsRLKSF 720
Cdd:COG4886   56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS------NLTNLESLDLSGN-QLTDL 128

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15242937  721 PD-ISS--NISELYLNRTAIEEVPWWIQKFSRLKRLRMRECKkLKCISPNISKLKHLEMLDFSNC 782
Cdd:COG4886  129 PEeLANltNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKELDLSNN 192
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
641-782 1.35e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.41  E-value: 1.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937  641 LWGSKKLKEIPDLSLATNLETLYLNDCSSLVELPSSIKNLNKLWDLGMKGCEKLELLPTDI--NLKSLYRLDLGRCSRLK 718
Cdd:COG4886   31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDlgDLTNLTELDLSGNEELS 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15242937  719 SFpdisSNISELYLNRTAIEEVPWWIQKFSRLKRLRMRECkKLKCISPNISKLKHLEMLDFSNC 782
Cdd:COG4886  111 NL----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNN-QLTDLPEPLGNLTNLKSLDLSNN 169
NB-ARC pfam00931
NB-ARC domain;
187-426 1.97e-08

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 56.23  E-value: 1.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937    187 IEGHIAKISLMLCLECkQVRMFGIWGPSGIGKTTIARALFSR---ISRHFQGSVFLdraFVSKSMEIYsggnvdnynakl 263
Cdd:pfam00931    1 REDMVEKVIGKLSEKD-EPGIVGIHGMGGVGKTTLAAQIFNDfdeVEGHFDSVAWV---VVSKTFTIS------------ 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937    264 HLQGKFLSEI-LRAKDIKISNLGVVGER----LKHMKVLIFIDDLDDQVVLDALASKPHWFGCGSRIIVITKDKQFFRAH 338
Cdd:pfam00931   65 TLQQTILQNLgLSEDDWDNKEEGELARKirraLLTKRFLLVLDDVWDEEDWDKIGIPLPDRENGCRVLLTTRSEEVAGRV 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937    339 G-IGLFYEVGLPSDKLALEMFSQSAFRQNS-PPPGFTELASEVSKRSGNLPLALNVLGSHLRGRDKED-W---IDMLPRL 412
Cdd:pfam00931  145 GgPSDPHEVELLEPDEAWELFENKVFPKTLgECELLEDVAKEIVEKCRGLPLALKVLGGLLSCKKTVEeWkhvYDVLQSE 224

                          250
                   ....*....|....
gi 15242937    413 RKGLDGKIEKILRV 426
Cdd:pfam00931  225 LKSNSYSLNSVRSI 238
COG4916 COG4916
Uncharacterized conserved protein [Function unknown];
10-110 7.55e-07

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443944 [Multi-domain]  Cd Length: 236  Bit Score: 51.27  E-value: 7.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937   10 YDVFPSFSGEDvR--VTFLSHFLKELDrklISVFKDNDIQrSQSLDPELKLAIRD-----SRIAIVVFSKNYAASSWCLD 82
Cdd:COG4916    1 YDVALSFAGED-RefVERVAEALKARG---IKVFYDENEE-AELWGKDLDEYLQDiyrseSRFVVVFLSKDYVEKKWTGL 75

                         90       100
                 ....*....|....*....|....*....
gi 15242937   83 ELLEIV-KCKEEFGQIVIPVFygLDPCHV 110
Cdd:COG4916   76 ERRAALaRAMQRKKEYILPIR--LDDTEI 102
C-JID pfam20160
C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron ...
 803-846 1.61e-06

C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron microscopy (cryoEM) structures of plant intracellular immune receptors containing Toll/interleukin-1 receptor (TIR, PF01582), nucleotide-binding (NB-ARC, PF00931) and leucine-rich repeat (LRR) domains (TIR-NLRs). Structurally, the C-JID core is represented by a beta-sandwich made up of 8 to 9 beta-strands. C-JID matches the so-called post LRR domain originally detected via a set of MEME motifs. The domain showed a strong distribution bias towards TIR-NLRs of dicotyledonous plant species despite broader taxonomic distribution of TIR-NLR in plant groups. Structure-function analyses of cryoEM structures suggest that C-JID domains play a role in substrate-recognition, such as binding to effector proteins from pathogens, and thus are involved in the initiation of signaling by TIR-NLR receptors. Presence of C-JID (or post-LRR) and its importance for the function of Arabidopsis TIR-NLR RPS4 that partners with RRS1 for effector recognition suggest that C-JID has additional functions.


Pssm-ID: 466313  Cd Length: 108  Bit Score: 47.83  E-value: 1.61e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 15242937    803 FPGGQVPLYFTYQATGSSLAIplSLHQSSLSQQLLGFRACVVLD 846
Cdd:pfam20160    1 LPGSQIPEWFNHQSTGSSISI--KLPENWYNDNFLGFAVCAVGS 42
LRR_3 pfam07725
Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the ...
 612-631 1.75e-05

Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the pfam00560 model.


Pssm-ID: 429621 [Multi-domain]  Cd Length: 20  Bit Score: 42.33  E-value: 1.75e-05
                           10        20
                   ....*....|....*....|
gi 15242937    612 YLVVLRMQHSKLEKLWQGVQ 631
Cdd:pfam07725    1 NLVELNMPYSKLEKLWEGVK 20
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
613-711 1.62e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242937  613 LVVLRMQHSKLEKLWQGVQPLTCLREMQLWGSKkLKEIPD-LSLATNLETLYLNDCSsLVELPSsIKNLNKLWDLGMKGC 691
Cdd:COG4886  184 LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQ-LTDLPEpLANLTNLETLDLSNNQ-LTDLPE-LGNLTNLEELDLSNN 260

                         90       100
                 ....*....|....*....|
gi 15242937  692 eKLELLPTDINLKSLYRLDL 711
Cdd:COG4886  261 -QLTDLPPLANLTNLKTLDL 279
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 211-233 1.81e-03

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 41.97  E-value: 1.81e-03
                         10        20
                 ....*....|....*....|...
gi 15242937  211 WGPSGIGKTTIARALFSRISRHF 233
Cdd:COG2256   55 WGPPGTGKTTLARLIANATDAEF 77
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 211-233 2.98e-03

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 41.22  E-value: 2.98e-03
                          10        20
                  ....*....|....*....|...
gi 15242937   211 WGPSGIGKTTIARALFSRISRHF 233
Cdd:PRK13342   42 WGPPGTGKTTLARIIAGATDAPF 64
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
210-234 8.47e-03

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 39.83  E-value: 8.47e-03
                         10        20
                 ....*....|....*....|....*
gi 15242937  210 IWGPSGIGKTTIARALFSRISRHFQ 234
Cdd:COG1474   56 IYGPTGTGKTAVAKYVLEELEEEAE 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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