|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
36-470 |
6.21e-167 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 478.99 E-value: 6.21e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 36 EARSLFSLAFPTILAALILYARSAISMLFLGHIGELELAGGSLAIAFANITGYSVLAGLALGMDPLCSQAFGAGRPKLLS 115
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 116 LTLQRTVLFLLTSSVVIVALWLNLGKIMIYLHQDPSISSLAQTYILCSIPDLLTNSFLHPLRIYLRAQGITSPLTLATLA 195
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 196 GTIFHIPMNFFLVSYLGWGFMGVSMAAAASNLLVVIFLVAHVWIAGLHQPTWTRPSSECFKDWGPVVTLAIPSCIGVCLE 275
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 276 WWWYEIMTVLCGLLiDPSTPVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRPNKARLSAIVAVSFAGVMGLTAS 355
Cdd:cd13132 241 WWAFEILVLLAGLL-PGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 356 AFAWGVSDVWGWIFTNDVAIIKLTAAALPILGLCELGNCPQTVGCGVVRGTARPSMAANINLGAFYLVGTPVAVGLTFWA 435
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399
|
410 420 430
....*....|....*....|....*....|....*
gi 15241158 436 AYGFCGLWVGLLAAQICCAAMMLYVVATTDWEKEA 470
Cdd:cd13132 400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEA 434
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
38-459 |
8.77e-52 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 181.50 E-value: 8.77e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 38 RSLFSLAFPTILAALILYARSAISMLFLGHIGELELAGGSLAIAFANITgYSVLAGLALGMDPLCSQAFGAGRPKLLSLT 117
Cdd:COG0534 8 KLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARRV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 118 LQRTVLFLLTSSVVIVAL-WLNLGKIMIYLHQDPSISSLAQTY----ILCSIPDLLTNSFlhplRIYLRAQGITSPLTLA 192
Cdd:COG0534 87 LGQALLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYlriiLLGLPFLLLFNVL----NGILRGLGDTKTPMII 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 193 TLAGTIFHIPMNFFLVSYLGWGFMGVSMAAAASNLLVVIFLVAHVWIAGLHQPTWTRPSSECFKDWGPVVTLAIPSCIGV 272
Cdd:COG0534 163 MLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQ 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 273 CLEWwwyeIMTVLCGLLIDP--STPVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRPNKARLSAIVAVSFAGVM 350
Cdd:COG0534 243 LAES----LGFLVLNALVARlgTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 351 GLTASAFAWGVSDVWGWIFTNDVAIIKLTAAALPILGLCELGNCPQTVGCGVVRGTARPSMAANINLGAFYLVGTPVAVG 430
Cdd:COG0534 319 GLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYL 398
|
410 420
....*....|....*....|....*....
gi 15241158 431 LTFWaAYGFCGLWVGLLAAQICCAAMMLY 459
Cdd:COG0534 399 LAFL-GLGLTGVWLALPIGEVLRALLLLL 426
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
36-459 |
1.22e-47 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 170.76 E-value: 1.22e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 36 EARSLFSLAFPTILAALILYARSAISMLFLGHIGELELAGGSLAIAFaNITGYSVLAGLALGMDPLCSQAFGAGRPKLLS 115
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSL-WFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 116 LTLQRTVLFLLTSSVVIVALWLNLGKIMIYLHQDPSISSLAQTYILCSIPDLLTNSFLHPLRIYLRAQGITSPLTLATLA 195
Cdd:cd13131 80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 196 GTIFHIPMNFFLVsYLGWGF--MGVSMAAAASNLLVVIFLVAHVWIAGLHQP--------TWTRPSsecFKDWGPVVTLA 265
Cdd:cd13131 160 ALVLNIPLNYVLI-FGKFGLpaLGGAGAGLATAIVYWLMFLALAFYIRRHKRfrryrlfaRFWRPD---WARLKELLRLG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 266 IPSCIGVCLEWWWYEIMTVLCGLLidPSTPVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRPNKARLSAIVAVS 345
Cdd:cd13131 236 LPIGLTIFFEVSLFAAVALLMGRL--GTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 346 FAGVMGLTASAFAWGVSDVWGWIFTNDVAIIKLTAAALPILGLCELGNCPQTVGCGVVRG---TARPSMAANInlgAFYL 422
Cdd:cd13131 314 LGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGykdTRVPFLLALI---SYWG 390
|
410 420 430
....*....|....*....|....*....|....*..
gi 15241158 423 VGTPVAVGLTFWAAYGFCGLWVGLLAAQICCAAMMLY 459
Cdd:cd13131 391 IGLPLGYLLAFTTGLGAFGVWIGLIIGLALAAILLLW 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
46-387 |
3.43e-46 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 164.34 E-value: 3.43e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 46 PTILAALILYARSAISMLFLGHIGELELAGGSLAiAFANITGYSVLAGLALGMDPLCSQAFGAGRPKLLSLTLQRTVLFL 125
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 126 LTSSVVIVALWLNLGKIMIYLHQ-DPSISSLAQTYILCSIPDLLTNSFLHPLRIYLRAQGITSPLTLATLAGTIFHIPMN 204
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGaDGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 205 FFLVsYLGWGFMGVSMAAAA---SNLLVVIFLVAHVWIAGLHQPTWTRPSSECFKDWGPVVTLAIPSCIGVCLEWWWYEI 281
Cdd:TIGR00797 160 YILI-FGKFGFLGIVGAALAtviSYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 282 MTVLCGLLidPSTPVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRPNKARLSAIVAVSFAGVMGLTASAFAWGV 361
Cdd:TIGR00797 239 LALLVARL--GSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILF 316
|
330 340
....*....|....*....|....*.
gi 15241158 362 SDVWGWIFTNDVAIIKLTAAALPILG 387
Cdd:TIGR00797 317 REFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
27-459 |
1.06e-29 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 121.07 E-value: 1.06e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 27 FPTITELKSEARSLFSLAFPTILAALILYARSAISMLFLGHIGELELAGGSLAIAFAnITGYSVLAGLALGMDPLCSQAF 106
Cdd:PRK01766 1 MKETQKYKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIW-LPVILFGHGLLLALTPIVAQLN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 107 GAGRPKLLSLTLQRTVLFLLTSSVVIVALWLNLGKIMIYLHQ-DPSISSLAQTYILC---SIPDLLtnsFLHPLRIYLRA 182
Cdd:PRK01766 80 GAGRRERIAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNlEPEVADIAVGYLHAllwGIPAYL---LYQVLRSFIDG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 183 QGITSPLTLATLAGTIFHIPMNFFLVsYLGWGF-----MGVSMAAAASNLLVVIFLVAHVWIA------GLHQpTWTRPS 251
Cdd:PRK01766 157 LGKTKPTMVIGFLGLLINIPLNYIFI-YGKFGFpelggVGCGVATAIVYWVMFLAMLIYIKRArrfrdfRLFK-GLYKPD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 252 secFKDWGPVVTLAIPSCIGVCLEWWWYEIMTvlcgLLIDP--STPVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELG 329
Cdd:PRK01766 235 ---WAVIKRLLKLGLPIGLAIFFEVSLFAVVT----LLVSPlgTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 330 SNRPNKARLSAIVAVSFAGVMGLTASAFAWGVSDVWGWIFTNDVAIIKLTAAALPILGLCELGNCPQTVGCGVVRGTARP 409
Cdd:PRK01766 308 AGRTLDARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDT 387
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 15241158 410 SMAANINLGAFYLVGTPVAVGLTFWAAYGFCGLWVGLLAAQICCAAMMLY 459
Cdd:PRK01766 388 RVIFFITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLL 437
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
38-466 |
1.26e-29 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 120.69 E-value: 1.26e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 38 RSLFSLAFPTILAALILYARSAISMLFLGHIGELELAGGSLAIAFANITgYSVLAGLALGMDPLCSQAFGAGRPKLLSLT 117
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLL-LVLNMALGTGTVALVSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 118 LQRTVLF-LLTSSVVIVALWLNLGKIMIYLHQDPSISSLAQTYILcsiPDLLTNSFLHPLRIY---LRAQGITSPLTLAT 193
Cdd:cd13137 80 LGQSLLLaLLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLR---IVLLGIPFFFLSLVGnaaLRGAGDTKTPMYIM 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 194 LAGTIFHIPMNFFLVSYL----GWGFMGVSMAAAASNLLVVIFLVAHVWIAGLHQPTWTRPSSECFKDWGPVVTLAIPSC 269
Cdd:cd13137 157 IIVNVLNIVLDYVLIFGLwgfpGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKISFKGFRLDRKIIKKLLRIGLPAG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 270 IGVCLewwWYEIMTVLCGLLIDPSTPV-ASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRPNKARLSAIVAVSFAG 348
Cdd:cd13137 237 LEQLL---RSLGFLVLLAIVASYGTAAlAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGV 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 349 VMGLTASAFAWGVSDVWGWIFTNDVAIIKLTAAALPILGLCELGNCPQTVGCGVVRGT--ARPSMAanINLGAFYLVGTP 426
Cdd:cd13137 314 LFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAgdTRPPLI--INLISMWLVRLP 391
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 15241158 427 VAVGLTFWAAYGFCGLWVGLLAAQICCAAMMLYVVATTDW 466
Cdd:cd13137 392 LAYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKW 431
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
46-206 |
5.18e-27 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 106.50 E-value: 5.18e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 46 PTILAALILYARSAISMLFLGHIGELELAGGSLAIAFANITgYSVLAGLALGMDPLCSQAFGAGRPKLLSLTLQRTVLFL 125
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 126 LTSSVVIVAL-WLNLGKIMIYLHQDPSISSLAQTYILCSIPDLLTNSFLHPLRIYLRAQGITSPLTLATLAGTIFHIPMN 204
Cdd:pfam01554 80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 15241158 205 FF 206
Cdd:pfam01554 160 YL 161
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
44-461 |
6.80e-27 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 112.42 E-value: 6.80e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 44 AFPTILAALILYARSAISMLFLGHIGELELAGGSLAIAFANITgYSVLAGLALGMDPLCSQAFGAGRPKLLSLTLQRTVL 123
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALL-IALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 124 FLLTSSVVIVALWLNLGKIMIYL-HQDPSISSLAQTYILCSIPDLLTNSFLHPLRIYLRAQGITSPLTLATLAGTIFHIP 202
Cdd:cd12082 80 LAILLGLLLAALLLFFSPLILSLlGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 203 MNFFLVSYLGWGFMGVS---MAAAASNLLVVIFLVAHVWIAGLHQPTWTRPSSECFKDWGPVVTLAIPSCIGVCLEWWWY 279
Cdd:cd12082 160 LDPLLIFGLGPPELGIAgaaLATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 280 EIMTVLCGLLIDPSTpVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRPNKARLSAIVAVSFAGVMGLTASAFAW 359
Cdd:cd12082 240 LIIVAIVAAFGGAAA-LAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLIL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 360 GVSDVWGWIFTNDVAIIKLTAAALPILGLCELGNCPQTVGCGVVRGTARPSMAANINLGAFYLVGTPVAVGLTfWAAYGF 439
Cdd:cd12082 319 LFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLA-YLGLGL 397
|
410 420
....*....|....*....|..
gi 15241158 440 CGLWVGLLAAQICCAAMMLYVV 461
Cdd:cd12082 398 YGIWLALVISLILAALVLLLFF 419
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
38-461 |
1.50e-24 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 105.67 E-value: 1.50e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 38 RSLFSLAFPTILAALILYARSAISMLFLGH-IGELELAGGSLAIAFAN-ITGYSVLAGLalGMDPLCSQAFGAGRPKLLS 115
Cdd:cd13143 4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHgVGALALAAVNLVFPIIMlLMALGLMIGV--GGASLISRRLGAGDREKAN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 116 LTLQRTVLFLLTSSVVIVALWLNLGKIMIYLHQ-DPSISSLAQTY---ILCSIPDLLTNSFLHPLriyLRAQGITSPLTL 191
Cdd:cd13143 82 RIFSTALLLSLILGLLLTILGLLFLDPLLRLLGaSGELLPYAVDYlriILLGAPFTILSSVLNNL---LRAEGKPKLAML 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 192 ATLAGTIFHIPMNFFLVSYLGWGFMGVSMAAAASNLLVVIFLVAHVWiaglHQPTWTRPS----SECFKDWGPVVTLAIP 267
Cdd:cd13143 159 GMLIGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFF----RGKSLLKLSllrfKLSLKIIKEILALGFP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 268 SCIGvclewwwyEIMTVLCGLLI-------DPSTPVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRPNKARLSA 340
Cdd:cd13143 235 SFLM--------QLSSSVVTIVLnltllgyGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQAL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 341 IVAVSFAGVMGLTASAFAWGVSDVWGWIFTNDVAIIKLTAAALPILGLCELGNCPQTVGCGVVRGTARPSMAANINLGAF 420
Cdd:cd13143 307 KLALIVALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQ 386
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 15241158 421 YLVGTPVAVGLTFWaaYGFCGLWVGLLAAQICCAAMMLYVV 461
Cdd:cd13143 387 GLFLIPLLLILPRL--FGLDGIWLAFPLAEILTLLLALILL 425
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
267-428 |
4.44e-24 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 98.41 E-value: 4.44e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 267 PSCIGVCLEWWWYEIMTVLCGLLidPSTPVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRPNKARLSAIVAVSF 346
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHL--GAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLIL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 347 AGVMGLTASAFAWGVSDVWGWIFTNDVAIIKLTAAALPILGLCELGNCPQTVGCGVVRGTARPSMAANINLGAfYLVGTP 426
Cdd:pfam01554 79 GLLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIP 157
|
..
gi 15241158 427 VA 428
Cdd:pfam01554 158 LN 159
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
38-467 |
5.68e-24 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 104.08 E-value: 5.68e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 38 RSLFSLAFPTILAALILYARSAISMLFLGHI-GELELAGGSLAIAFANITgYSVLAGLALGMDPLCSQAFGAGRPKLLS- 115
Cdd:cd13138 3 KTLLLFALPLLLSNLLQQLYNLVDLLIVGQFlGVAALAAVSNGSPIIFLL-TAIGMGLSMGGTILISQYIGAKDEEKAKk 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 116 LTLQRTVLFLLTSSVVIVALWLNLGKIMIYLHQDPSISSLAQTYI---LCSIPDLLTNSFLHPLriyLRAQGIT-SPLTL 191
Cdd:cd13138 82 AVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLricFLGIPFIFGYNAYSAI---LRGLGDSkTPLYF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 192 ATLAgTIFHIPMNFFLVSYLGWGFMGVSMAAAASNLLVVIFLVAHVWIAGLHqptwTRPSSECFK-DW---GPVVTLAIP 267
Cdd:cd13138 159 VIIA-CVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLP----FKLSLKDFRfDKeilKEILKIGLP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 268 SCIgvclewwwyEIMTVLCGLLIDPS-------TPVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRPNKARLSA 340
Cdd:cd13138 234 SAL---------QQSLVSISFLIINSivnsygvVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 341 IVAVSFAGVMGLTASAFAWGVSDVWGWIFTNDVAIIKLTAAALPILGLCELGNCPQTVGCGVVRGTARPSMAANINLGAF 420
Cdd:cd13138 305 RTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRL 384
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 15241158 421 YLVGTPVAVGLTFWAAYGFCGLWVGLLAAQICCAAMMLYVVATTDWE 467
Cdd:cd13138 385 WLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
38-447 |
7.96e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 103.76 E-value: 7.96e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 38 RSLFSLAFPTILAALILYARSAISMLFLGHIGELELAGGSLAiAFANITGYSVLAGLALGMDPLCSQAFGAGRPKLLSLT 117
Cdd:cd13133 5 REILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPA-GVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 118 LQRTVLFLLTSSVVIVAL-WLNLGKIMIYLHQDPSISSLAQTY----ILCSIPDLLTNSFlhplRIYLRAQGITSPLTLA 192
Cdd:cd13133 84 LWQGLYFSLLLAPLLALLsALAAPLLFLLLGHSPEVQALEVEYfrirILGAPFSLLGAAL----RAFFSGIGRTRVVMVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 193 TLAGTIFHIPMNFFLVsYLGWGF--MGVSMAAAAS---NLLVVIFLVAHVWIAGLHQ----PTWTRPSSECFKDwgpVVT 263
Cdd:cd13133 160 NLVMVVVNIVLDYALI-FGKLGFpaMGIAGAAIATviaEAVSLLFFLLLLFRRKNRRrfglRRAWRFDRELLRR---ILR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 264 LAIPSCIGVCLEWWWYEIMTVLCGLLidPSTPVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRPNKARLSAIVA 343
Cdd:cd13133 236 LGLPSGLQFFLDVGAFTVFFLLIGRL--GTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 344 VSFA-GVMGLTASAFAWGVSDVWGwIFTNDV---AIIKLTAAALPILGLCELGNCPQTVGCGVVRGT--ARPSMAANINL 417
Cdd:cd13133 314 LKLAlAYMLLLGILFLLFPELLLS-IFTPGAdfaLIAELAVPLLRFVAAYILFDALALVFAGALRGAgdTRFVMLAELIV 392
|
410 420 430
....*....|....*....|....*....|....*....
gi 15241158 418 GAFYLV---------GTPVAVGLTFWAAYGFCGLWVGLL 447
Cdd:cd13133 393 AWLYLLppayllvvlGAGLAGAWTVETVYVIVLALIFLL 431
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
38-471 |
9.48e-21 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 94.49 E-value: 9.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 38 RSLFSLAFPTILAALILYARSAISMLFLGHIGELELAGGSLAIAFANItGYSVLAGLALGMDPLCSQAFGAGRPKLLSLT 117
Cdd:cd13134 3 LSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFL-LILIFSFISTGTSILIAQYLGAKDKKKARQI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 118 LQRTVLFLLTSSVVIVALWLNLGKIMIYLHQ-DPSISSLAQTYILCSIPDLLTNSFLHPLRIYLRAQGITSPLTLATLAG 196
Cdd:cd13134 82 AGVALLFNLLLGLVFSLLLLFFGAELLRLMGlPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 197 TIFHIPMNFFLVsyLGWGF---MGVSMAAAASNLLVVIFLVAHVWIagLHQPTWTRPSSECF-----KDWGPVVTLAIPS 268
Cdd:cd13134 162 NILNIVGNYLLI--FGWFGlpkLGVAGVAISTVISRAVGLVLLFIL--LFRKLKIRFRLKDLrpfpkKLLKKILKIGLPS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 269 CIGVCLEWWWYEIMTVLCGLLIdpSTPVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRPNKARLSAIVAVSFAG 348
Cdd:cd13134 238 AGEELSYNLSQTVITAFIARLG--TAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 349 VMGLTASAFAWGVSDVWGWIFTNDVAIIKLTAAALPILGLCELGNCPQTVGCGVVRGTARPSMAANINLGAFYLVGTPVA 428
Cdd:cd13134 316 LVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLA 395
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 15241158 429 VGLTFWAAYGFCGLWVGLLAAQICCAAMMLYVVATTDWEKEAI 471
Cdd:cd13134 396 YLLGIVLGLGLLGVWIAFAADEWVRGIIMLWRWRSGKWIKKAL 438
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
37-468 |
6.03e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 79.93 E-value: 6.03e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 37 ARSLFSLAFPTILAALILYARSAISMLFLGHIGELELAggSLAIAFANI-TGYSVLAGLALGMDPLCSQAFGAGRPKLLS 115
Cdd:cd13142 10 LRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVA--APSISWPLIfLFISLGGGLTVAGTALVAQYTGAGDYDKAN 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 116 LTLQRTVLFLLTSSVVI-VALWLNLGKIMIYL-HQDPSISSLAQTYILCSIPDLLTNSFLHPLRIYLRAQGITSPLTLAT 193
Cdd:cd13142 88 KVAGQTFSFVIILSLILaVLGYILSRPLLLLLiGAPEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMKIM 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 194 LAGTIFHIPMNFFLVsyLGWGF---MGVSMAAAASNLLVVIFLVAHVWI-----AGLH-QPTWTRPSSECFKDwgpVVTL 264
Cdd:cd13142 168 FGSVLLNVILDPLLI--FGIGPfpgLGVAGAALATVISRGIAAVIGLYLlfkgrVGLKiSLRDLKPDWEWLKK---IFRI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 265 AIPSCIGVCLEWWWYEIMTVLCGLLidPSTPVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRPNKARLSAIVAV 344
Cdd:cd13142 243 GLPSSIEQSARALGFTVMTALVAGF--GTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 345 SFAGVMGLTASAFAWGVSDVWGWIFTNDVAIIKLTAAALPILGLCELGNCPQTVGCGVVRGTARPSMAANINLGAFYLVG 424
Cdd:cd13142 321 LLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIR 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 15241158 425 TPVAVGLTFWAAYGFCGLWVGLLAAQICCAAMMLYVVATTDWEK 468
Cdd:cd13142 401 IPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTWKK 444
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
37-409 |
7.22e-14 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 73.33 E-value: 7.22e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 37 ARSLFSLAFPTILAALILYARSAISMLFLGHIGELELAG-GslAIAFANITGYSVLAGLALGMDPLCSQAFGAGRPKLLS 115
Cdd:cd13140 4 LKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAvG--TAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEAR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 116 LTLQRTVL--FLLTSSVVIVALWLNLGKIMIYLHQDPSISSLAQTYILCSIPDLLTnSFLHPL--RIYlRAQGITSPLTL 191
Cdd:cd13140 82 KYARNALQlnLLLGILYGLLLLLFAKPLIGFFNLGDAEVISLAITYLRIVALGLIF-SFLNPVftGIF-NALGDSKTPFI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 192 ATLAGTIFHIPMNFFLVsyLGWGF---MGVSMAAAA---SNLLV-VIFLVAHVWIAGL--HQPTWTRPSSECFKDwgpVV 262
Cdd:cd13140 160 INAIGLVLNIILDPLLI--FGFGPfpaLGVAGAALAtvlAQAIVfLLFLYALKKKKGLflKIRILKRPDRKYIKE---IL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 263 TLAIPSCIGVCLewwwYEIMTVLCGLLIDP--STPVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRPNKARLSA 340
Cdd:cd13140 235 KLGLPVALQSIL----FALISMILARIIASfgPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGY 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15241158 341 IVAVSFAGVMGLTASAFAWGVSDVWGWIFTNDVAIIKLTAAALPILGLCELGNCPQTVGCGVVRGTARP 409
Cdd:cd13140 311 KTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRT 379
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
28-459 |
7.68e-14 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 73.63 E-value: 7.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 28 PTITELKSearsLFSLAFPTILAALILYARSAISMLFLGHIGELELAGGSLAIAFANITGYSVLaGLALGMDPLCSQAFG 107
Cdd:PRK00187 4 PPTTELKA----ILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSIFCV-GVIAAVGTLVAIRHG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 108 AGRPKLLSLTLQRTVLFLLTSSVVIVALWLNLGKIMIYLHQDPSISSLAQTYILC---SIPDLLTnsfLHPLRIYLRAQG 184
Cdd:PRK00187 79 AGDIEGATRLAQAGLWLAWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLHLlpfALPGYLS---FMALRGFTSALG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 185 ITSPLTLATLAGTIFHIPMNFFLVSylGW------GFMGVSMAAAASNLLVVIFLVAHVWIAGLHQP-----TWTRPSSE 253
Cdd:PRK00187 156 RAGPVMVISLAGAVANLLLNYALIE--GWfglpklGLMGIGLVTALVSNGMALALALYIRRHPAYAAyplrkGLSRPSRA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 254 CFKDwgpVVTLAIPSCIGVCLEWWWYEIMTVLCGLLidPSTPVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRP 333
Cdd:PRK00187 234 ALRE---LWRLGLPIGGTYAVEVGLFTFAALCMGAL--GSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 334 NKARLSAIVAVSFAGVMGLTASAFAWGVSDVWGWIFT--NDVA---IIKLTAAALPILGLCELGNCPQTVGCGVVRGTAR 408
Cdd:PRK00187 309 LEARRAGRVGIGFGAVVMLLFAGLFWLLPEAIIGLFLdrNDPAfaeIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKD 388
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 15241158 409 PSMAANINLGAFYLVGTPVAVGLTFWAAYGFCGLWVGlLAAQICCAAMMLY 459
Cdd:PRK00187 389 ARTTFLIGLACYWLVGAPLAWLLAFTLGWGAVGVWWG-LALGLACAAVALT 438
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
38-448 |
4.54e-13 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 71.05 E-value: 4.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 38 RSLFSLAFPTILAALILYARSAISMLFLGHIGEL-ELAGGSLAIAFANITgYSVLAGLALGMDPLCSQAFGAGRPKLLSL 116
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHLGSAaYLGAVALGTTIFNTL-FWLFGFLRMGTTGLVAQALGAGDREEAIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 117 TLQRTVLFLLTSSVVIVALWLNL-GKIMIYLHQDPSISSLAQTY---ILCSIPDLLTNSFLHPlriYLRAQGITSPLTLA 192
Cdd:cd13136 82 LLVRALLLALAIGLLLILLQSPLlALALLLLGASAAVAALARQYlriRILGAPAVLLNYVATG---WFRGLQDTRTPLIL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 193 TLAGTIFHIPMNFFLVSYLGWGFMGVSMAAAASNLLVVIFLVAHVWIAGLHQPTWTRPSSECFKDWGPVVTLAIP----- 267
Cdd:cd13136 159 QIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPSKAALKRLFKLNRDifirt 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 268 SCIGVCLEWwwyeiMTVLCGLLIDpsTPVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRPNKARLSAIVAVSFA 347
Cdd:cd13136 239 LALLAAFLF-----FTALAARLGD--VILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWG 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 348 GVMGLTASAFAWGVSDVWGWIFTNDVAIIKLTAAALPILGLCELGNCPQTVGCGVVRGTARPSMAANINLGAFyLVGTPV 427
Cdd:cd13136 312 LGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVSL-AVFLPL 390
|
410 420
....*....|....*....|.
gi 15241158 428 AVGLtfWAAYGFCGLWVGLLA 448
Cdd:cd13136 391 LFLL--VPLWGNHGLWLALIL 409
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
34-235 |
4.75e-13 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 70.94 E-value: 4.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 34 KSEARSLFSLAFPTILAALILYARSAISMLFLGHIGELELAGGSLAIAFANITgYSVLAGLALGMDPLCSQAFGAGRPKL 113
Cdd:COG0534 225 RKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLA-FMPALGLGQAAQPLVGQNLGAGDYDR 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 114 LSLTLQRTVLFLLTSSVVIVALWLNLGKIMIYL-HQDPSISSLAQTYILCSIPDLLTNSFLHPLRIYLRAQGITSPLTLA 192
Cdd:COG0534 304 ARRAARLALLLALGIGLLLALLLFLFPEPIIGLfTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMII 383
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 15241158 193 TLAGT-IFHIPMNFFLvSYLGWGFMGVSMAAAASNLLVVIFLVA 235
Cdd:COG0534 384 SLLRLwLVRLPLAYLL-AFLGLGLTGVWLALPIGEVLRALLLLL 426
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
37-451 |
5.34e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 48.84 E-value: 5.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 37 ARSLFSLAFPTILAALILYARSAISMLFLGHIGELELAggslAIAFANITGY---SVLAGLALGMDPLCSQAFGAG-RPK 112
Cdd:cd13149 8 PRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELA----AISFTFPVVLflnSLTIGLGIGASAVISRAIGAGdRNK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 113 LLSLTLQRTVLFLLTSSVVIVALWLNLGKIMIYLHQDPSISSLAQTY--------ILCSIPDLLTNSflhplriyLRAQG 184
Cdd:cd13149 84 AKRLATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYmaiwylglVFLVLPMVGNAI--------IRATG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 185 IT-SPLTLATLAGTIFHIPMNFFLVSYLGWGFMGVSMAAAASNLLVVIFLVAHVWIAGLHQP--TWTRPS-SECFKDWGP 260
Cdd:cd13149 156 DTkRPSLVMLGAALVNVILDPILIFGFGPIPGMGIAGAAIATVISRALGLGAALYFLHYHHRliDFSEPSlKALFRSWKD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 261 VVTLAIPSCIGVCLEWWWYEIMTVLCGLLIDPStpVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRPNKARLSA 340
Cdd:cd13149 236 ILSIGIPAALSNILTPLSAAFITALVATYGPAA--VAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 341 IVAVSFAGVMGLTASAFAWGVSDVWGWIFTNDVAIIKLTAAALPILGLCELGNCPQTVGCGVVRGTARPSMAANINLGAF 420
Cdd:cd13149 314 KISLKFSLIYGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRV 393
|
410 420 430
....*....|....*....|....*....|..
gi 15241158 421 YLVGTPVA-VGLTFwaaYGFCGLWVGLLAAQI 451
Cdd:cd13149 394 FLLYIPLAyVGSHL---LGFAGVFIGALAGNL 422
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
64-461 |
1.74e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 47.21 E-value: 1.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 64 FLGHIGELELAGGSLAI-AFANITGYSVlaGLALGMDPLCSQAFGAGRPKLLSLTLQRTVLFLLTSSVVIVALWLNLGKI 142
Cdd:cd13145 35 FAGKISTEALAALSLSFpIFFIIIAIGV--GIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLTVIGLFAAPP 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 143 MI-YLHQDPSISSLAQTY---ILCSIPDLLTNSFLHPLriyLRAQGITSPLTLATLAGTIFHIPMN-FFLVSYLGWGFMG 217
Cdd:cd13145 113 LFrLLGAEGDYLDLALEYmdvIFAGSIFFLLNFGLNGI---LNAQGDTKSYRNFLIIGFFLNIILDpLFIFGGGGIPAMG 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 218 VSMAAAA---SNLLVVIFLVAHVWIAGLHQPTWTR---PSSECFKDwgpVVTLAIPSCIgvclewwwyEIMTVLCGLLID 291
Cdd:cd13145 190 VSGIALAtiiSQFIGMFYLLYKVRKSGIISGCRLRdfiPRLDVYKE---ILKQGFPASL---------NMMTIGLGIFVI 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 292 P-------STPVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELGSNRPNKARLSAIVAVSFAGVMGLTASAFAWGVSDV 364
Cdd:cd13145 258 TyfvgqfgDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVVATVFLLFFAEP 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 365 WGWIFTNDVAIIK----------LTAAALPILGLCelgncpqtvgCGVVRGTARPSMAANINLGAFYLVGTPVAVGLTFW 434
Cdd:cd13145 338 LMSLFTNDPAVIAigagylridaLIFYAYVVLFIS----------VSVLQGLKRPIFALWIGLYRQLVGPALVFWLLVNV 407
|
410 420
....*....|....*....|....*..
gi 15241158 435 AAYGFCGLWVGLLAAQICCAAMMLYVV 461
Cdd:cd13145 408 LGLGVTGIWWGIFTIVWSAAIIALLYT 434
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
35-238 |
1.76e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 47.31 E-value: 1.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 35 SEARSLFSLAFPTILAALILYARSAISMLFLGHIGELELAGGSLAiafANITGYSVLAG--LALGMDPLCSQAFGAGRPK 112
Cdd:cd13141 8 SIPKHIISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLA---GNVMFFVMALTqvLNVGTAALVSHAVGRKDQG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 113 LLSLTLQRTVLFLLTSSVVIVALWLNLGKI-MIYLHQDPSISSLAQTYILCSIPDLLTNSFLHPLRIYLRAQGITSPLTL 191
Cdd:cd13141 85 EANAVFNQSLLLAAVLGLVVLVLGYLFGRLyLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMV 164
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 15241158 192 ATLAGTIFHIPMNFFLVSylGWGF---MGVSMAAAASNLLVVIFLVAHVW 238
Cdd:cd13141 165 IQILAVLLNIILAPILIT--GWGTgraLGVAGAGLASSISVAIAVVLLLY 212
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
40-234 |
2.64e-05 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 46.48 E-value: 2.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 40 LFSLAFPTILAALILYARSAISMLFLGHIGELELAGG-SLAIAFANITgYSVLAGLALGMDPLCSQAFGAGRPKLLSLTL 118
Cdd:COG2244 175 VLKYSLPLLLSGLLGLLLTNLDRLLLGALLGPAAVGIySAAYRLASLL-LLLITALSQVLFPRLSRLLAEGDREELRRLY 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 119 QRTVLFLLTSSVVIVALWLNLGKIMIYLHQDPSISSlAQTYILCSIPDLLTNSFLHPLRIYLRAQGITSPLTLATLAGTI 198
Cdd:COG2244 254 RKALRLLLLLGLPLALGLALLAPPLLSLLFGPEYAE-AAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAV 332
|
170 180 190
....*....|....*....|....*....|....*.
gi 15241158 199 FHIPMNFFLVSYlgWGFMGVSMAAAASNLLVVIFLV 234
Cdd:COG2244 333 LNLVLNLLLIPR--YGLVGAAIATLLSYLVLLLLLL 366
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
34-233 |
4.65e-05 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 45.97 E-value: 4.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 34 KSEARSLFSLAFPTILAALILYARSAISMLFLGHIGELELAGGSLAIafaNITGYSVLAGLALGM--DPLCSQAFGAGRP 111
Cdd:cd13137 222 RKIIKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGL---RIESLAFMPGFGFSMaaSTLVGQNLGAGDP 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 112 KLLSLTLQRTVLF-LLTSSVVIVALWLNLGKIMIYLHQDPSISSLAQTYILCSIPDLLTNSFLHPLRIYLRAQGITSPLT 190
Cdd:cd13137 299 DEARRYGKRALRLgVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPL 378
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 15241158 191 LATLAGT-IFHIPMNFFLVSYLGWGFMGVSMAAAASNLLVVIFL 233
Cdd:cd13137 379 IINLISMwLVRLPLAYLLGFVLGLGLTGIWLAMFVDTIVRAILL 422
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
38-398 |
9.46e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 44.98 E-value: 9.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 38 RSLFSLAFPTILAALILYARSAISMLFLGHIGELELAG-GSLAIAFANITGysVLAGLALGMDPLCSQAFGAGRPKLLSL 116
Cdd:cd13135 1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAvGNVTTPFNTITG--FLGSISIGFTILGSQSVGAKDIKRIND 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 117 TLQRTVLFLLTSSVVIVALWLNLGKIMIYLHQ-DPSISSLAQTYILCSIPDLLTNSFLHPLRIYLRAQGITSPLTLATLA 195
Cdd:cd13135 79 YAISSIVYNSIIGVILFLLWLFGARIIFVLFGvDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGII 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 196 GTIFHIPMNFFLVsYLGWGF-----MGVSMAAAASNLLVVIFLVAHVWIA-----GLHQPTWTRPSSECFKDwgpVVTLA 265
Cdd:cd13135 159 KNLLNVILDYVLI-FGNFGFprlgiIGAAIATTIANVLNLIILVYLCRKIkkltfKLSNTKVLKANIRPYKF---TIKLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 266 IPSCIGvclEWWWYEIMTVLCGLLIDPSTPVASMGILIQTTSLLYIFP-SSLGLAVSTRVGNELGSNRPNKARLSAIVAV 344
Cdd:cd13135 235 LPLGGE---EFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPmYGYSSAALTLVGESIGKKDLKEALRIGNICL 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 15241158 345 SFAGVMGLTASAFAWGVSDVWGWIFTNDVAIIKLTAAALPILGLCELGNCPQTV 398
Cdd:cd13135 312 GLGLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIV 365
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
38-161 |
2.59e-04 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 43.00 E-value: 2.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 38 RSLFSLAFPTILAALILYARSAISMLFLGHIGELELAGGSLAIAFANITgYSVLAGLALGMDPLCSQAFGAGRPKLLSLT 117
Cdd:TIGR00797 216 KRLLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVESLL-FMPAFGFGIAVSILVGQALGAGDPKRAKEV 294
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 15241158 118 LQRTVLFLLTSSVVIVALWLNLGKIMIYLH-QDPSISSLAQTYIL 161
Cdd:TIGR00797 295 ARVALKLSLLLGLVLAIILILFREFIARLFtNDPEVLELAAIYLI 339
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
38-225 |
3.11e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 42.99 E-value: 3.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 38 RSLFSLAFPTILAALILYARSAISMLFLGHIGELELAGGSLAIAFANITgYSVLAGLALGMDPLCSQAFGAGRPKLLSLT 117
Cdd:cd13144 8 RLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLM-IAVAVGTGVGVNALLSRSLGEKDQKEANKA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 118 LQRTVLFLLTSSVVIVALWLNLGKIMIYLHQD-PSISSLAQTYILCSIPDLLTNSFLHPLRIYLRAQGITSPLTLATLAG 196
Cdd:cd13144 87 ANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDdPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIG 166
|
170 180 190
....*....|....*....|....*....|
gi 15241158 197 TIFHIPMN-FFLVSYLGWGFMGVSMAAAAS 225
Cdd:cd13144 167 AIINIILDpILIFGLFGFPAMGIAGAAIAT 196
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
93-234 |
6.26e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 42.39 E-value: 6.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 93 GLALGMDPLCSQAFGAGRPKLLSLTLQRTVLFLLTSSVVIVALWLNLGKIMI-YLHQDPSISSLAQTYILCSIPDLLTNS 171
Cdd:cd13146 65 GIQVGVSSLLARAIGAQRAKELDQAADSGLALALLAATVIVVLGYIFAEPLLqLLGAKGLLLEYALEYFYYSLPGVPFIM 144
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15241158 172 FLHPLRIYLRAQGITSPLTLATLAGTIFHIPMNFFLVSYLGWGFMGVSMAAAASNLLVVIFLV 234
Cdd:cd13146 145 LIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLL 207
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
14-232 |
8.42e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 41.83 E-value: 8.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 14 SKIDLEKQNPAPIFPTItelkseaRSLFSLAFPTILAALIlyarSAISMLFL----GHIGELELAGGSLAIafaNITGYS 89
Cdd:cd13139 222 GRIQIRRRHLKLDWAII-------KKIIKIAVGGILQFLI----ASSSWIFLvriiAEFGSTALAGYTIAI---RIIMFA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 90 VLA--GLALGMDPLCSQAFGAGRP----KLLSLTLQRTVLFLLtssVVIVALWLNLGKIMIYLHQDPSISSLAQT----- 158
Cdd:cd13139 288 LLPawGLSNAAATLVGQNLGAGQPdraeKSVWRAGKYNMVFLG---IVSLVFFLFAEPLVSFFTTDPEVIAIAVEalrii 364
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15241158 159 ---YILCSIPDLLTNSFlhplriylRAQGITSPLTLATLAGT-IFHIPMNFFLVSYLGWGFMGVSMAAAASNLLVVIF 232
Cdd:cd13139 365 slgYIFYGYGMVLSQAF--------NGAGDTKTPTLINLVGFwLFQIPLAYLLARHLNLGPKGVFIAIPIAETVLAIA 434
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
24-459 |
3.94e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 39.56 E-value: 3.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 24 APIFPTitelksearsLFSLAFPTILAALILYARSAISMLFLGHIGELELAGGSLAIAFANITGYSVLAGLALGMDPLCS 103
Cdd:cd13148 8 APILPT----------LLRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLMLTQMMSNGAMGGGVSSAIA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 104 QAFGAGR-PKLLSLTLQRTVLFLLTSSVVIVALWLNLGKIMIYLHQDPSISSLAQTYILC----SIPDLLTNSflhpLRI 178
Cdd:cd13148 78 RALGAGDrERAEALVWHALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVlfsgAILIWLVNL----LAA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 179 YLRAQGITSPLTLATLAGTIFHIPMNFFLVsyLGWGFM------GVSMAAAASNLLVVIFLVAHVWIA-GLHQPTWTRPS 251
Cdd:cd13148 154 ALRGTGNMRVPALVTLVGAVVQIPLSPGLI--LGWGPLprlgvaGAAVAAVLYYALAALVLLRYLASGrSRLRLRLRALR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 252 SE--CFKDWGPVvtlAIPSCIGVCLEWWWYEIMTVLCGLLidPSTPVASMGILIQTTSLLYIFPSSLGLAVSTRVGNELG 329
Cdd:cd13148 232 LErrLFRDILRV---GLLAALSPLQTNLTVLLLTGLVGRF--GTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIG 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15241158 330 SNRPNKAR----LSAIVAVSFAGVMGLTASAFAwgvsDVWGWIFTNDVAIIKLTAAALPILGLCELgncpqTVGCGVVRG 405
Cdd:cd13148 307 AGQIARARriawTGALMAAVLAGAIGLVLALFP----ELWLGLFTHDPAVLAAGASYLRIVGPFYG-----FFGLGLALY 377
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 15241158 406 TArpSMAANINLGAFyLVGTP---VAVGLTFWAAYGFCGLWVGLLAAQicCAAMMLY 459
Cdd:cd13148 378 FA--SQGAGRMLWPV-LAGTLrllIAAGGGWIAVALFGAGLAGLFAAA--AAAMVAY 429
|
|
| |
