|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
34-469 |
2.44e-150 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 436.23 E-value: 2.44e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 34 EVRKMWRIALPSTLFRVMSFGCVVVAQAFIGHSSETGLAAYALLQSTFIRFIYGIMAGMSSATETLCGQAYGAEQYHMMG 113
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 114 IYLQRSWIVDTFIATLFVPFIVLAGPILRLLGQNVVISETVDEIYPWVIPYLYSIVFTMTMQMYLQAQMKNAIIGILSTL 193
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 194 ALVLDIAATWWCVSVMGMGIHGALLGLNISSWSVAIAEFVYVFGGW-CPHTWTGFSTAAFLDLIPMLKLSISSGFMLCLE 272
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKgHKATWGGFSREAFRGWGPFLKLAIPSALMLCLE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 273 YWYMSIIVLMSGYAKdANIAISAFSICQYIYSWEMNICFGLMGAACVRVANELGKGDADAVRFSIKVVLVVSAVIGVICS 352
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 353 ALCLAFGGQISYLFSDSQAVSDAVADLSIVLSISILFNIIQPILSGVAIGAGMQSMVALVNLASYYAIGVPLGVLLVYVF 432
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399
|
410 420 430
....*....|....*....|....*....|....*..
gi 22326870 433 NFGIKGLWSGMLAGVGIQTLILCYVIYKTDWELEVKK 469
Cdd:cd13132 400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
36-454 |
8.23e-44 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 159.92 E-value: 8.23e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 36 RKMWRIALPSTLFRVMSFGCVVVAQAFIGHSSETGLAAYALLqSTFIRFIYGIMAGMSSATETLCGQAYGAEQYHMMGIY 115
Cdd:COG0534 8 KLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLA-FPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 116 LQRSWIVDTFIATLF-VPFIVLAGPILRLLGQNvviSETVDEIYPWVIPYLYSIVFT---MTMQMYLQAQMKNAIIGILS 191
Cdd:COG0534 87 LGQALLLALLLGLLLtLLGLLFAPPLLRLLGAD---PEVLALARDYLRIILLGLPFLllfNVLNGILRGLGDTKTPMIIM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 192 TLALVLDIAATWWCVSVMGMGIHGALLGLNISSWSVAIAEFVYVFGGWCPHTWTGFSTAAFLDLI-PMLKLSISSGFMLC 270
Cdd:COG0534 164 LIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILkRILRIGLPAGLQQL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 271 LEYWYMSIIVLMSGYAKDAniAISAFSICQYIYSWEMNICFGLMGAACVRVANELGKGDADAVRFSIKVVLVVSAVIGVI 350
Cdd:COG0534 244 AESLGFLVLNALVARLGTA--AVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 351 CSALCLAFGGQISYLFSDSQAVSDAVADLSIVLSISILFNIIQPILSGVAIGAGMQSMVALVNLASYYAIGVPLGVLLVY 430
Cdd:COG0534 322 LALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF 401
|
410 420
....*....|....*....|....
gi 22326870 431 vFNFGIKGLWSGMLAGVGIQTLIL 454
Cdd:COG0534 402 -LGLGLTGVWLALPIGEVLRALLL 424
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
61-384 |
1.74e-33 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 129.67 E-value: 1.74e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 61 AFIGHSSETGLAAYALlQSTFIRFIYGIMAGMSSATETLCGQAYGAEQYHMMGIYLQRSWIVDTFIATLFVPFIVLAGPI 140
Cdd:TIGR00797 18 AFVGHLGPVDLAAVSL-GSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLALLLGLPVLLVGYFFIDP 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 141 LRLLGQ--NVVISETVD--EIYPWVIP-YLYSIVFtmtmQMYLQAQMKNAIIGILSTLALVLDIAATWWCV--SVMGMGI 213
Cdd:TIGR00797 97 LLSLMGadGEVAELAQDylRILILGIPaYLLNFVL----RGFLRGQGDTKTPMYITLIGNVINIILNYILIfgKFGFLGI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 214 HGALLGLNISSWSVAIAEFVYVFGGW-CPHTWTGFSTAAFLDLIPMLKLSISSGFMLCLEYWYMSIIVLMSGYAKDanIA 292
Cdd:TIGR00797 173 VGAALATVISYWLMFLLLLYYIKKAKkIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALLALLVARLGS--IA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 293 ISAFSICQYIYSWEMNICFGLMGAACVRVANELGKGDADAVRFSIKVVLVVSAVIGVICSALCLAFGGQISYLFSDSQAV 372
Cdd:TIGR00797 251 LAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFREFIARLFTNDPEV 330
|
330
....*....|..
gi 22326870 373 SDAVADLSIVLS 384
Cdd:TIGR00797 331 LELAAIYLIFVA 342
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
36-463 |
4.61e-30 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 121.85 E-value: 4.61e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 36 RKMWRIALPSTLFRVMSFGCVVVAQAFIGHSSETGLAAYALLqSTFIRFIYGIMAGMSSATETLCGQAYGAEQYHMMGIY 115
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLA-TQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 116 LQRSWIVDTFIATLF-VPFIVLAGPILRLLGQNvviSETVDEIYPWVIPYLYSIVFTMTMQMY---LQAQmKNAIIG-IL 190
Cdd:cd13137 80 LGQSLLLALLLSLPLaLLGLLFAEPLLRLLGAD---PEVIALALTYLRIVLLGIPFFFLSLVGnaaLRGA-GDTKTPmYI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 191 STLALVLDIAAT------WWcvSVMGMGIHGALLGLNISSWSVAIAEFVYVFGGW----CPHTWTGFSTAAFLDLipmLK 260
Cdd:cd13137 156 MIIVNVLNIVLDyvlifgLW--GFPGLGVAGAALATVISRVVGALLLLFLLLRGRlpikISFKGFRLDRKIIKKL---LR 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 261 LSISSGFMLCLeyWYMSIIVLMSGYAKDANIAISAFSICQYIYSWEMNICFGLMGAACVRVANELGKGDADAVRFSIKVV 340
Cdd:cd13137 231 IGLPAGLEQLL--RSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRA 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 341 LVVSAVIGVICSALCLAFGGQISYLFSDSQAVSDAVADLSIVLSISILFNIIQPILSGVAIGAGMQSMVALVNLASYYAI 420
Cdd:cd13137 309 LRLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLV 388
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 22326870 421 GVPLGVLLVYVFNFGIKGLWSGMLAGVGIQTLILCYVIYKTDW 463
Cdd:cd13137 389 RLPLAYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKW 431
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
34-463 |
1.04e-29 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 120.68 E-value: 1.04e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 34 EVRKMWRIALPSTLFRVMSFGCVVVAQAFIGHSSETGLAAYALLQSTFIRFIYGIMaGMSSATETLCGQAYGAEQYHMMG 113
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGM-GLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 114 IYLQRSWIVDTFIATLFVPFIVLAGPILRLLGQNvvisetvDEIYPWVIPYLYSIVF-------TMTMQMYLQAQMKNAI 186
Cdd:cd13131 80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQE-------PEVAAIARGYLLALAWgippallFQVLRSFLDALGRTRP 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 187 IGILSTLALVLDIAATWWCVS----VMGMGIHGALLGLNISSWSVAIAEFVYVFGGW---CPHTWTGFSTAAFLDLIPML 259
Cdd:cd13131 153 AMVITLLALVLNIPLNYVLIFgkfgLPALGGAGAGLATAIVYWLMFLALAFYIRRHKrfrRYRLFARFWRPDWARLKELL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 260 KLSISSGFMLCLEYWYMSIIVLMSGYAKDA-----NIAISAFSICqyiysweMNICFGLMGAACVRVANELGKGDADAVR 334
Cdd:cd13131 233 RLGLPIGLTIFFEVSLFAAVALLMGRLGTTvlaahQIALNFASLL-------FMVPLGISMAATVRVGFALGAGDPADAR 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 335 FSIKVVLVVSAVIGVICSALCLAFGGQISYLFSDSQAVSDAVADLSIVLSISILFNIIQPILSGVAIGAGMQSMVALVNL 414
Cdd:cd13131 306 RAGLVGLGLGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLAL 385
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 22326870 415 ASYYAIGVPLGVLLVYVFNFGIKGLWSGMLAGVGIQTLILCYVIYKTDW 463
Cdd:cd13131 386 ISYWGIGLPLGYLLAFTTGLGAFGVWIGLIIGLALAAILLLWRFRRLQR 434
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
42-459 |
3.75e-29 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 118.97 E-value: 3.75e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 42 ALPSTLFRVMSFGCVVVAQAFIGHSSETGLAAYAL---LQSTFIRFIYGIMAGMSSATetlcGQAYGAEQYHMMGIYLQR 118
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLafpLIALLIALGVGLSVGTSALI----SQAIGAGDEEKARRVLVQ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 119 S-WIVDTFIATLFVPFIVLAGPILRLLGQNVVISETVDEIYPWVIPYLYSIVFTMTMQMYLQAQMKNAIIGILSTLALVL 197
Cdd:cd12082 77 SiVLAILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 198 DIAATWWCVSVMG---MGIHGALLGLNISSWSVAIAEFVYVF-GGWCPHTWTGFSTAAFLDLIPMLKLSISSGFMLCLEY 273
Cdd:cd12082 157 NILLDPLLIFGLGppeLGIAGAALATVISYVIGALLLLIYLRkGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 274 WYMSIIVLMSGYAKDANiAISAFSICQYIYSWEMNICFGLMGAACVRVANELGKGDADAVRFSIKVVLVVSAVIGVICSA 353
Cdd:cd12082 237 LGLLIIVAIVAAFGGAA-ALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 354 LCLAFGGQISYLFSDSQAVSDAVADLSIVLSISILFNIIQPILSGVAIGAGMQSMVALVNLASYYAIGVPLGVLLVYVfN 433
Cdd:cd12082 316 LILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYL-G 394
|
410 420
....*....|....*....|....*.
gi 22326870 434 FGIKGLWSGMLAGVGIQTLILCYVIY 459
Cdd:cd12082 395 LGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
61-464 |
1.19e-21 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 97.14 E-value: 1.19e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 61 AFIGH-SSETGLAAYALLqSTFIRFIYGIMAGMSSATETLCGQAYGAEQYHMMGIYLQRSWIVDTFIATLFVPF-IVLAG 138
Cdd:cd13138 28 LIVGQfLGVAALAAVSNG-SPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKAVGTLLVLFLILGIVLTILgLLFAP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 139 PILRLLGqnvviseTVDEIYPWVIPYLY----SIVFTMTMQMY---LQAQMKNAIIGILSTLALVLDIAATWWCVSVMGM 211
Cdd:cd13138 107 PILRLMN-------TPAEILELAVSYLRicflGIPFIFGYNAYsaiLRGLGDSKTPLYFVIIACVLNIILDLLFIAVFHM 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 212 GIHGALLGLNISSWSVAIAEFVYVFggwcphtWTGFSTAAFLD--------LIPMLKLSISSGFMLCLEYwyMSIIVLMS 283
Cdd:cd13138 180 GVAGAALATVIAQAISVLLALYYLR-------KKKLPFKLSLKdfrfdkeiLKEILKIGLPSALQQSLVS--ISFLIINS 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 284 GYAKDANIAISAFSICQYIYSWEMNICFGLMGAACVRVANELGKGDADAVRFSIKVVLVVSAVIGVICSALCLAFGGQIS 363
Cdd:cd13138 251 IVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLVFFFAPQLL 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 364 YLFSDSQAVSDAVADLSIVLSISILFNIIQPILSGVAIGAGMQSMVALVNLASYYAIGVPLGVLLVYVFNFGIKGLWSGM 443
Cdd:cd13138 331 GLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLSRLTGLGLFGIWLAM 410
|
410 420
....*....|....*....|.
gi 22326870 444 LAGVGIQTLILCYVIYKTDWE 464
Cdd:cd13138 411 PISNILSAIICIIYYRKGRWK 431
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
35-463 |
1.62e-21 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 96.83 E-value: 1.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 35 VRKMWRIALPStlfrVMSFGCVVVAQ----AFIGHSSETGLAAyALLQSTFIRFIYGIMAGMSSATETLCGQAYGAEQYH 110
Cdd:cd13133 4 YREILKIALPL----VLSMLSQTVMGftdrAFLGRLSEVALAA-SGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 111 MMGIYLQRSWIVDTFIATLFVPFIVLAGPILRLLgqnvVISEtvDEIYPWVIPYL----YSIVFTMTMQM---YLQAQMK 183
Cdd:cd13133 79 RIGRVLWQGLYFSLLLAPLLALLSALAAPLLFLL----LGHS--PEVQALEVEYFririLGAPFSLLGAAlraFFSGIGR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 184 NAIIGILSTLALVLDIAATWWCV----SVMGMGIHGALLGLNISSWSVAiaeFVYVFGGWCPHTWTGFSTAAFL-----D 254
Cdd:cd13133 153 TRVVMVANLVMVVVNIVLDYALIfgklGFPAMGIAGAAIATVIAEAVSL---LFFLLLLFRRKNRRRFGLRRAWrfdreL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 255 LIPMLKLSISSGFMLCLEYWYMSIIVLMSGYAKDANIAISafSICQYIYSWEMNICFGLMGAACVRVANELGKGDADAVR 334
Cdd:cd13133 230 LRRILRLGLPSGLQFFLDVGAFTVFFLLIGRLGTTELAAT--NIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAM 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 335 FSIKVVLVVSAVIGVICSALCLAFGGQISYLFS---DSQAVSDAVADLSIVLSISILFNIIQPILSGVAIGAGMQSMVAL 411
Cdd:cd13133 308 RVTRRGLKLALAYMLLLGILFLLFPELLLSIFTpgaDFALIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVML 387
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 22326870 412 VNLASYYAIGVPLGVLLVYVFnFGIKGLWSGMLAGVGIQTLILCYVIYKTDW 463
Cdd:cd13133 388 AELIVAWLYLLPPAYLLVVLG-AGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
36-440 |
2.38e-18 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 87.18 E-value: 2.38e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 36 RKMWRIALPSTLFRVMSFGCVVVAQAFIGH-SSETGLAAYALLqSTFIRFIYGIMAGMSSATETLCGQAYGAEQYHMMGI 114
Cdd:cd13143 4 KLFLKFALPAIIGMLVNGLYNIVDGIFVGHgVGALALAAVNLV-FPIIMLLMALGLMIGVGGASLISRRLGAGDREKANR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 115 YLQRS-WIVDTFIATLFVPFIVLAGPILRLLGQNvvisetvDEIYPWVIPYLYSIV-------FTMTMQMYLQAQMKNAI 186
Cdd:cd13143 83 IFSTAlLLSLILGLLLTILGLLFLDPLLRLLGAS-------GELLPYAVDYLRIILlgapftiLSSVLNNLLRAEGKPKL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 187 IGILSTLALVLDIAATWWCVSVMGMGIHGALLGLNISSWSVAIAEFVYVFGG--WCPHTWtGFSTAAFLDLIPMLKLSIS 264
Cdd:cd13143 156 AMLGMLIGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGksLLKLSL-LRFKLSLKIIKEILALGFP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 265 SGFMlcleYWYMSIIVLM---SGYAKDANIAISAFSICQYIYSWEMNICFGLMGAACVRVANELGKGDADAVRFSIKVVL 341
Cdd:cd13143 235 SFLM----QLSSSVVTIVlnlTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLAL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 342 VVSAVIGVICSALCLAFGGQISYLFSDSQAVSDAVADLSIVLSISILFNIIQPILSGVAIGAGMQSMVALVNLASYYAIG 421
Cdd:cd13143 311 IVALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFL 390
|
410
....*....|....*....
gi 22326870 422 VPLGVLLVYVfnFGIKGLW 440
Cdd:cd13143 391 IPLLLILPRL--FGLDGIW 407
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
32-234 |
1.98e-16 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 81.34 E-value: 1.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 32 WSEVRKMWRIALPSTLFRVMSFGCVVVAQAFIGHSSETGLAAYALLqSTFIRFIYGIMAGMSSATETLCGQAYGAEQYHM 111
Cdd:COG0534 225 RKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIA-LRIESLAFMPALGLGQAAQPLVGQNLGAGDYDR 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 112 MGIYLQRSWIVDTFIATLF-VPFIVLAGPILRLLGQNVVISETVDEIYPWVIPYLYSIVFTMTMQMYLQAQMKNAIIGIL 190
Cdd:COG0534 304 ARRAARLALLLALGIGLLLaLLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMII 383
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 22326870 191 STLALVLDIAATWWCVSVMGMGIHGALLGLNISSWSVAIAEFVY 234
Cdd:COG0534 384 SLLRLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
36-445 |
8.79e-16 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 79.47 E-value: 8.79e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 36 RKMWRIALP----STLFRVMSFgcvvVAQAFIGHSSETGLAAYALLqSTFIRFIYGIMAGMSSATETLCGQAYGAEQYHM 111
Cdd:cd13134 3 LSLFALAWPifieLLLQMLLGT----IDTFMLSRYSDNAVAAVGVA-NQILFLLILIFSFISTGTSILIAQYLGAKDKKK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 112 MGIYLQRSWIVDTFIATLF-VPFIVLAGPILRLLGQNvvisetvDEIYPWVIPYL----YSIVFT---MTMQMYLQAQMK 183
Cdd:cd13134 78 ARQIAGVALLFNLLLGLVFsLLLLFFGAELLRLMGLP-------PELLALGSTYLrivgGSLFLQalsLTLSAILRSHGR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 184 NAIIGILSTLALVLDIAATWwcVSVMG------MGIHGALLGLNISSWSVAIAEFVYVFGgwcpHTWTGFSTAAFLDLI- 256
Cdd:cd13134 151 TKIPMYVSLIMNILNIVGNY--LLIFGwfglpkLGVAGVAISTVISRAVGLVLLFILLFR----KLKIRFRLKDLRPFPk 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 257 PMLKLSISSGFMLCLEY--WYMSIIVLMSGYAKDANIAISAFSICQYIYSWEMNICFGLMGAACVRVANELGKGDADAVR 334
Cdd:cd13134 225 KLLKKILKIGLPSAGEElsYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAY 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 335 FSIKVVLVVSAVIGVICSALCLAFGGQISYLFSDSQAVsdaVADLSIVLSISIL------FNIiqpILSGVAIGAGMQSM 408
Cdd:cd13134 305 KRVLKSLKIGLLVSLAVALLLALFREPILGLFTDDPEI---IALGKTLLLISILlepgraFNI---VLIGSLRAAGDARF 378
|
410 420 430
....*....|....*....|....*....|....*..
gi 22326870 409 VALVNLASYYAIGVPLGVLLVYVFNFGIKGLWSGMLA 445
Cdd:cd13134 379 PVLIGIISMWGISVPLAYLLGIVLGLGLLGVWIAFAA 415
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
265-427 |
2.87e-15 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 73.37 E-value: 2.87e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 265 SGFMLCLEYWYMSIIVLMSGYAKDanIAISAFSICQYIYSWEMNICFGLMGAACVRVANELGKGDADAVRFSIKVVLVVS 344
Cdd:pfam01554 2 IALENLLQSLYSLIDTLFVGHLGA--VALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 345 AVIGVICSALCLAFGGQISYLFSDSQAVSDAVADLSIVLSISILFNIIQPILSGVAIGAGMQSMVALVNLASyYAIGVPL 424
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPL 158
|
...
gi 22326870 425 GVL 427
Cdd:pfam01554 159 NYL 161
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
36-460 |
5.02e-15 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 76.83 E-value: 5.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 36 RKMWRIALPSTLFRVMSFGCVVVAQAFIGH-SSETGLAAYALlQSTFIRFIYGIMAGMSSATETLCGQAYGAEQYHMMGI 114
Cdd:cd13136 3 REILALALPAILSNITVPLLGLVDTAVVGHlGSAAYLGAVAL-GTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 115 YLQRSWIVDTFIATLFvpfIVLAGPILRLLGQNVVISEtvdEIYPWVIPYLYSIVF-------TMTMQMYLQAQMKNAII 187
Cdd:cd13136 82 LLVRALLLALAIGLLL---ILLQSPLLALALLLLGASA---AVAALARQYLRIRILgapavllNYVATGWFRGLQDTRTP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 188 GILSTLALVLDIAATWWCVSVMGMGIHGALLGLNISSWSVAIAEFVYVFGGWCPHTWTGFStaAFLDLIPMLKLSISSGF 267
Cdd:cd13136 156 LILQIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSR--RLPSKAALKRLFKLNRD 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 268 M----LCLEYWYMSIIVLMSGYAkdaNIAISAFSICQYIYSWEMNICFGLMGAACVRVANELGKGDADAVRFSIKVVLVV 343
Cdd:cd13136 234 IfirtLALLAAFLFFTALAARLG---DVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQW 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 344 SAVIGVICSALCLAFGGQISYLFSDSQAVSDAVADLSIVLSISILFNIIQPILSGVAIGAG----MQSMVaLVNLASYya 419
Cdd:cd13136 311 GLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATdtryLRNSM-LVSLAVF-- 387
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 22326870 420 igvpLGVLLVYVFNFGIKGLWSGMLAGVGIQTLILCYVIYK 460
Cdd:cd13136 388 ----LPLLFLLVPLWGNHGLWLALILFMLLRGLTLALRLPR 424
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
84-443 |
5.16e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 76.85 E-value: 5.16e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 84 FIYGIMAGMSSATETLCGQAYGAEQYHMMGIYLQRSWIVDTFIATLF-VPFIVLAGPILRLLGQnvviseTVDEIYPWVI 162
Cdd:cd13142 58 LFISLGGGLTVAGTALVAQYTGAGDYDKANKVAGQTFSFVIILSLILaVLGYILSRPLLLLLIG------APEEVYPLAL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 163 PYLYSI-----------VFTMTMQMYLQAQMKNAIIGILSTLALVLD---IAATWwcvSVMGMGIHGALLGLNISSWSVA 228
Cdd:cd13142 132 AYLRIIflglpfmfiffVFNSLLRGIGDTKTPMKIMFGSVLLNVILDpllIFGIG---PFPGLGVAGAALATVISRGIAA 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 229 IAEFVYVFGGWcphtwTGFSTAaFLDLIP---MLKLSISSGFMLCLEYWYMS--IIVLMSGYAKDANIAISAFSICQYIY 303
Cdd:cd13142 209 VIGLYLLFKGR-----VGLKIS-LRDLKPdweWLKKIFRIGLPSSIEQSARAlgFTVMTALVAGFGTVVVAAYGIGNRII 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 304 SWEMNICFGLMGAACVRVANELGKGDADAVRFSIKVVLVVSAVIGVICSALCLAFGGQISYLFSDSQAVSDAVADLSIVL 383
Cdd:cd13142 283 SLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIV 362
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 384 SISILFNIIQPILSGVAIGAGMQSMVALVNLASYYAIGVPLGVLLVYVFNFGIKGLWSGM 443
Cdd:cd13142 363 APSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPLAYLLAYVLGLGVTGIWIAM 422
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
62-204 |
6.53e-14 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 69.52 E-value: 6.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 62 FIGHSSETGLAAYALLQSTFIrFIYGIMAGMSSATETLCGQAYGAEQYHMMGIYLQRSWIVDTFIATLFVPFIVL-AGPI 140
Cdd:pfam01554 19 FVGHLGAVALAAVSIANSIAS-LIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGLLLSLPIALLVLLfSEPI 97
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22326870 141 LRLLGQNVVISETVDEIYPWVIPYLYSIVFTMTMQMYLQAQMKNAIIGILSTLALVLDIAATWW 204
Cdd:pfam01554 98 LSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLNYL 161
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
41-455 |
1.23e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 72.71 E-value: 1.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 41 IALPSTLFRVMSFGCVVVAQAFIGHSSETGLAAYALLQSTFIRfIYGIMAGMSSATETLCGQAYGAEQYHMMGIYLQRSW 120
Cdd:cd13135 6 IAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNT-ITGFLGSISIGFTILGSQSVGAKDIKRINDYAISSI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 121 IVDTFIA-TLFVPFIVLAGPILRLLG---QNVVISETVDEIYPwviPYLYSIVFTMTMQMYLQAQMKNAIIGILSTLALV 196
Cdd:cd13135 85 VYNSIIGvILFLLWLFGARIIFVLFGvdgQILGYSINYVRIFS---IYLLLLGILFTFSSILQGIGETKPIMYGGIIKNL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 197 LDIAATWwcVSVMG------MGIHGALLGLNISSWSVAIAEFVYVFGgWCPHTWTGFSTAAFLDLIPMLKLSISSGFMLC 270
Cdd:cd13135 162 LNVILDY--VLIFGnfgfprLGIIGAAIATTIANVLNLIILVYLCRK-IKKLTFKLSNTKVLKANIRPYKFTIKLGLPLG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 271 LEY--WYMSIIVLMSGYAKDANIAISAFSICQYIYSWEMNICFGLMGAACVRVANELGKGDADAVRFSIKVVLVVSAVIG 348
Cdd:cd13135 239 GEEflWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIY 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 349 VICSALCLAFGGQISYLFSDSQAVSDAVADLSIVLSISILFNIIQpILSGVAIGAGMQSMVALVNLASYYAIGVPLGVLL 428
Cdd:cd13135 319 IAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSIN-IVYGFAIRAIGDTKWMLYTQIIGTIIVVSVALLL 397
|
410 420
....*....|....*....|....*..
gi 22326870 429 VYVFNFGIKGLWSGMLAGVGIQTLILC 455
Cdd:cd13135 398 IFVFKLGLAGVYITLFIDEIIRAIINF 424
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
24-236 |
8.46e-13 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 70.05 E-value: 8.46e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 24 SLYLRKKIWSEVRKMWRIALPSTLFRVMSFGCVVVAQAFIG-HSSETGLAAYALLqSTFIRFIYGIMAGMSSATETLCGQ 102
Cdd:cd12082 207 KLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAaFGGAAALAAYTVA-FRIASLAFMPALGLAQAALPVVGQ 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 103 AYGAEQYHMMGIYLQRS-WIVDTFIATLFVPFIVLAGPILRLLGQNVVISETVDEIYPWVIPYLYSIVFTMTMQMYLQAQ 181
Cdd:cd12082 286 NLGAGNFDRARRITWVAlLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAA 365
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 22326870 182 MKNAIIGILSTLALVLDIAATWWCVSVMGMGIHGALLGLNISSWSVAIAEFVYVF 236
Cdd:cd12082 366 GRTLKSLIVSLLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
36-463 |
1.90e-11 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 66.10 E-value: 1.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 36 RKMWRIALPSTLFRVMSFGCVVVAQAFIGHSSETGLAAYALLQStFIRFIYGIMAGMSSATETLCGQAYGAEQYHMMGIY 115
Cdd:cd13139 14 RAIFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTES-VLTIVYSIAIGLSMAATALVARRIGEKDPEGAGFA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 116 LQRSWIVDTFIATLF-VPFIVLAGPILRLLGQNvvisetvdeiyPWVIPYLYS---IVF---TMTMQMYL---------Q 179
Cdd:cd13139 93 AVQAILLGVALSLILsILGYFFAEDILSLMGAS-----------PAVIAEGYGytrIMFggnGFIMLLFLingifrgagD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 180 AQMKNAIIGILSTLALVLDIAATWWCVSVMGMGIHGALLGLNISSWSVAIAEFVYVFGGWcphTWTGFSTAAFLDLIPML 259
Cdd:cd13139 162 AAIAMRSLWLANGLNIILDPLFIFGLGPIPAMGVTGAAIATTIGRSIGVLYQLYHLFKGK---GRIQIRRRHLKLDWAII 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 260 K--LSISSGFMLCLEYWYMSIIVLMSGYAKDANIAISAFSICQYIYSWEMNICFGLMGAACVRVANELGKGDADAVRFSI 337
Cdd:cd13139 239 KkiIKIAVGGILQFLIASSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 338 KVVLVVSAVIGVICSALCLAFGGQISYLFSDSQAVSDAVADLSIVLSISILFNIIQPILSGVAIGAGMQSMVALVNLASY 417
Cdd:cd13139 319 WRAGKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGF 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 22326870 418 YAIGVPLGVLLVYVFNFGIKGLWSGMLAGVGIQTLILCYVIYKTDW 463
Cdd:cd13139 399 WLFQIPLAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKW 444
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
87-446 |
1.26e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 60.11 E-value: 1.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 87 GIMAGMSSatetLCGQAYGAEQYHMMGIYLQRSWIVDTFIATLFVPFI-VLAGPILRLLGQNVVISETVDEIYPWVIPYL 165
Cdd:cd13146 65 GIQVGVSS----LLARAIGAQRAKELDQAADSGLALALLAATVIVVLGyIFAEPLLQLLGAKGLLLEYALEYFYYSLPGV 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 166 YSIVFTMTMQMYLQAQMKNAIIGILSTLALVLDIAATWWCVSVMGMGIHGALLGLNISSWSVaIAEFVYVFGG------- 238
Cdd:cd13146 141 PFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLAQAIS-LLYLLYVFLIgksnvti 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 239 -WCPHTWTGFSTAAFLD--LIPMLKLSISSGFMLCLEYWYMSIIVLmsgyakdaniAISAFSICQYIYSWEMNICFGLMG 315
Cdd:cd13146 220 hIKLSNISSSVIVEILRvgLPQMLLQLISSISFLIYNRIIIDIDPV----------AMTAFTLVGRLDQFILIPIFAISS 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 316 AACVRVANELGKGDADAVRFSIKVVLVVSAVIGVICSALCLAFGGQISYLFSDSQAVSDAVADLSIVLSISILFNIIQPI 395
Cdd:cd13146 290 ALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISIL 369
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 22326870 396 LSGVAIGAGMQSMVALVNLASYYAIGVPLGVLLVYVFNFGIKGLWSGMLAG 446
Cdd:cd13146 370 VTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLLAYVFGKGITGVYFGIVSA 420
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
25-461 |
1.41e-09 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 60.21 E-value: 1.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 25 LYLRKKIWSEVRKMWRIALPSTLFRV----MSFGCVVVAqafiGHSSETGLAAYALLQSTFIRFIYGIMaGMSSATETLC 100
Cdd:PRK01766 1 MKETQKYKSEARQLLALALPILLAQVaqtaMGFVDTVMA----GGVSATDLAAVAIGTSIWLPVILFGH-GLLLALTPIV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 101 GQAYGAEQYHMMGIYLQRSWIVDTFIATLFVPFIVLAGPILRLLGQnvvISETVDEIypwVIPYLYSIVFTM-------T 173
Cdd:PRK01766 76 AQLNGAGRRERIAHQVRQGLWLALFLSVLIMLVLYNAVPPILNMMN---LEPEVADI---AVGYLHALLWGIpayllyqV 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 174 MQMYLQAQMKNAIIGILSTLALVLDIAATWwcVSVMG------MGIHGALLGLNISSWSVAIAEFVYV--------FGGW 239
Cdd:PRK01766 150 LRSFIDGLGKTKPTMVIGFLGLLINIPLNY--IFIYGkfgfpeLGGVGCGVATAIVYWVMFLAMLIYIkrarrfrdFRLF 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 240 cpHTWTGFSTAAFLDLipmLKLSISSGFMLCLEYWYMSIIVLMSGYAKDANIAI--SAFSICQYIYSWEMNICFglmgAA 317
Cdd:PRK01766 228 --KGLYKPDWAVIKRL---LKLGLPIGLAIFFEVSLFAVVTLLVSPLGTVTVAAhqIALNFSSLLFMLPLSLAM----AL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 318 CVRVANELGKGDADAVRFSIKVVLVVSAVIGVICSALCLAFGGQISYLFSDSQAVsdaVADLSIVLSISILFNI---IQP 394
Cdd:PRK01766 299 TIRVGFELGAGRTLDARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEV---VALASHLLLFAALFQFsdaIQV 375
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22326870 395 ILSGVAIGAGMQSMVALVNLASYYAIGVPLGVLLVYVFNFGIKGLWSGMLAGVGIQTLILCYVIYKT 461
Cdd:PRK01766 376 IGSGALRGYKDTRVIFFITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLLRLRKL 442
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
38-445 |
1.84e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 59.53 E-value: 1.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 38 MWRIALPS---TLFRVMsFGcvVVAQAFIGHSSETGLAAYAL-LQSTFIrfIYGIMAGMSSATETLCGQAYGAEQYHMMG 113
Cdd:cd13145 11 IRKLAIPAsvgFFFNTM-FN--VVDTFFAGKISTEALAALSLsFPIFFI--IIAIGVGIGTGTTALIGNALGAGDRRKAR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 114 IYLQRSwIVDTFIATLFVPFI--VLAGPILRLLG-QNVVISETVDeiYPWVIpYLYSIVFTMTMQM--YLQAQ-----MK 183
Cdd:cd13145 86 RYAAQG-LSFGIILAILLTVIglFAAPPLFRLLGaEGDYLDLALE--YMDVI-FAGSIFFLLNFGLngILNAQgdtksYR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 184 NAIIGILStLALVLDIAATWWCVSVMGMGIHGallgLNISSWSVAIAEFVYVF------GGWCPHTWTGFstaaFLDLIP 257
Cdd:cd13145 162 NFLIIGFF-LNIILDPLFIFGGGGIPAMGVSG----IALATIISQFIGMFYLLykvrksGIISGCRLRDF----IPRLDV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 258 MLKLSiSSGFMLCLEYWYMSI-IVLMSGYAKD-ANIAISAFSICQYIYSWEMNICFGLMGAACVRVANELGKGDADAVRF 335
Cdd:cd13145 233 YKEIL-KQGFPASLNMMTIGLgIFVITYFVGQfGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRE 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 336 SIKVVLVVSAVIGVICSALCLAFGGQISYLFSDSQAVSDAVADL----SIVLSISILFNIIQPILSGVAigagmQSMVAL 411
Cdd:cd13145 312 TYKKALKYGFVIMVVATVFLLFFAEPLMSLFTNDPAVIAIGAGYlridALIFYAYVVLFISVSVLQGLK-----RPIFAL 386
|
410 420 430
....*....|....*....|....*....|....*
gi 22326870 412 -VNLASYYAIGVPLGVLLVYVFNFGIKGLWSGMLA 445
Cdd:cd13145 387 wIGLYRQLVGPALVFWLLVNVLGLGVTGIWWGIFT 421
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
36-460 |
4.54e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 58.31 E-value: 4.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 36 RKMWRIALPSTLFRVMSFGCVVVAQAFIGHSSETGLAAyALLQSTFIRFIYGIMAGMSSATETLCGQAYGAEQYHMMGIY 115
Cdd:cd13140 5 KTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAA-VGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEARKY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 116 LQRSWIVDTFIATLFVPFIVLAG-PILRL--LGQNVVISETVDeiYPWVIpyLYSIVFTMTMQMY---LQAQMKNAIIGI 189
Cdd:cd13140 84 ARNALQLNLLLGILYGLLLLLFAkPLIGFfnLGDAEVISLAIT--YLRIV--ALGLIFSFLNPVFtgiFNALGDSKTPFI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 190 LSTLALVLDIAATWWCVSVMG----MGIHGALLGLNISSWSVAIAEFVYVFGG----WCPHTWTGFSTAAFLDlipMLKL 261
Cdd:cd13140 160 INAIGLVLNIILDPLLIFGFGpfpaLGVAGAALATVLAQAIVFLLFLYALKKKkglfLKIRILKRPDRKYIKE---ILKL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 262 SISSGF---MLCLEYWYMSIIVlmsgyAKDANIAISAFSICQYIYSWEMNICFGLMGAACVRVANELGKGDADAVRFSIK 338
Cdd:cd13140 237 GLPVALqsiLFALISMILARII-----ASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYK 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 339 VVLVVSAVIGVICSALCLAFGGQISYLFSDSQAVSDAVADLSIVLSISILFNIIQPILSGVAIGAGMQSMVALVNLAsYY 418
Cdd:cd13140 312 TALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISIV-FN 390
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 22326870 419 AIGVPLGVLLVYvFNFGIKGLW-----SGMLAGVgIQTLILCYVIYK 460
Cdd:cd13140 391 GLRIPLALLLSP-TGLGLNGIWwaisiSSILKGI-ILTIWFLLYKKK 435
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
21-225 |
8.83e-09 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 57.51 E-value: 8.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 21 RRESLYLRKKIWSEVRKMWRIALPSTLFRVMSFGCVVVAQAFIGHSSETGLAAYALLqSTFIRFIYGIMAGMSSATETLC 100
Cdd:cd13134 213 RFRLKDLRPFPKKLLKKILKIGLPSAGEELSYNLSQTVITAFIARLGTAALAARTYA-SNISMFVFLFSLAIGQATQIIV 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 101 GQAYGAEQYHMMGIYLQRSWIVDTFIATLF-VPFIVLAGPILRLLGQNVVISETVDEIYPWVIPYLYSIVFTMTMQMYLQ 179
Cdd:cd13134 292 GHLVGAGDFDEAYKRVLKSLKIGLLVSLAVaLLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLR 371
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 22326870 180 A--QMK-NAIIGILSTLALVLDIAatWWCVSVMGMGIHGALLGLNISSW 225
Cdd:cd13134 372 AagDARfPVLIGIISMWGISVPLA--YLLGIVLGLGLLGVWIAFAADEW 418
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
21-239 |
1.70e-07 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 53.28 E-value: 1.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 21 RRESLYLRKKIWSEVRKMWRIALPSTLFRVMSFGCVVVAQAFIGHSSETGLAAYALLQSTFIrFIYGIMAGMSSATETLC 100
Cdd:cd13137 211 IKISFKGFRLDRKIIKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIES-LAFMPGFGFSMAASTLV 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 101 GQAYGAEQYHMMGIYLQRSWIVDTFIATLF-VPFIVLAGPILRLLGQNvviSETVDEIYPWVIPYLYSIVFT---MTMQM 176
Cdd:cd13137 290 GQNLGAGDPDEARRYGKRALRLGVLFMGLLgLLLFIFAPPLASLFTPD---PEVIELGVLYLRIVALSQPFLaisFVLSG 366
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22326870 177 YLQ---AQMKNAIIGILSTLALVLDIAatWWCVSVMGMGIHGALLGLNIS-SWSVAIAEFVYVFGGW 239
Cdd:cd13137 367 ALRgagDTRPPLIINLISMWLVRLPLA--YLLGFVLGLGLTGIWLAMFVDtIVRAILLLYRFRKGKW 431
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
24-236 |
1.49e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 50.48 E-value: 1.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 24 SLYLRKKIWSEVRKMWRIALPSTLFRVMSFGCVVVAQAFIGHSSETGLAAYALLqSTFIRFIYGIMAGMSSATETLCGQA 103
Cdd:cd13146 220 HIKLSNISSSVIVEILRVGLPQMLLQLISSISFLIYNRIIIDIDPVAMTAFTLV-GRLDQFILIPIFAISSALLTIAGQN 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 104 YGAEQYHMMGIYLQRSWIVDTFIATLFVPFIVLAGPILRLLGQNVV-ISETVDEIYPWVIPYLYSIVFTMTMQMYLQAQM 182
Cdd:cd13146 299 WGRGNYDRMLQILMTAVILGIVVVLVLVLGYVLVAPWLFSLFTTVPeVVAYAVLQVRTMALALPFVAISILVTEFFQAIG 378
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 22326870 183 KNAIIGILSTLAL-VLDIAATWWCVSVMGMGIHGALLGLNISSWSVAIAEFVYVF 236
Cdd:cd13146 379 KAWPSLLLTLIRHvFLSVPVVYLLAYVFGKGITGVYFGIVSANFFTALLAMFWGL 433
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
21-239 |
6.08e-06 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 48.61 E-value: 6.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 21 RRESLYLRKKIwseVRKMWRIALPSTL-FRVMSFGCVVVaQAFIGHSSETGLAAYALLqSTFIRFIYGIMAGMSSATETL 99
Cdd:cd13138 213 SLKDFRFDKEI---LKEILKIGLPSALqQSLVSISFLII-NSIVNSYGVVASAAYGIA-NKINSFAFLPPSAIGQAVSTF 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 100 CGQAYGAEQYHMMGIYLQRSWIVDTFIATLFVPFIVLAGP-ILRLLGQNVVISETVDEIYPWVIPYLYSIVFTMTMQMYL 178
Cdd:cd13138 288 VAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLVFFFAPqLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLF 367
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22326870 179 QAQMKNAIIGILSTLAL-VLDIAATWWCVSVMGMGIHGALLGLNISSWSVAIAEFVYVFGGW 239
Cdd:cd13138 368 RGLGKTKFPMIISILRLwLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGR 429
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
128-453 |
6.48e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 48.31 E-value: 6.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 128 TLFVPFIVLAGPILRLLGQNVVISETVDEIYPwVIPYLYSIVFTMTMQMYLQAQ--MKNAIIGIL--STLALVLD-Iaat 202
Cdd:cd13147 101 ILTIVLLPFLEPILVLMGAGEVLDLAVDYGRI-IFLGSIFLIFNNVAYGILRGEgdTKRAMYAMVagSILNIILDpI--- 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 203 wwCVSVMGMGIHGALLGLNISSWSVAIAEFVYVFGGwcPHTWTGFSTAAFLDLIPMLKLSISSGFMLCLEYWYMS----- 277
Cdd:cd13147 177 --FIYTLGLGIAGAAWATVISMLISSLVLLYWFFVK--KDTYVSLSLKNFKFDKKIVKDILKVGIPASLEQLIMSvlmii 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 278 ---IIVLMSGyakdaNIAISAFSICQYIYSWEMNICFGlMGAACVRVAN-----ELGKGDADAVRFSIKVVLVVSAVIGV 349
Cdd:cd13147 253 lnlILVIVAG-----TDGVAVYTAGWRIVSFAIIPLIG-IATAVTSVTGaaygaRNYEKLKTAYNYSIKLGLIIELIIAI 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 350 ICsalcLAFGGQISYLFSDSQAVSDAVADLSIVLSISILFNIIQP--ILSGV---AIGAGMQSMVALVNLASYYAIGVPL 424
Cdd:cd13147 327 LI----FIFAPQIAYLFTYSEESAHLAPEIVAFLRIMCLFLPFVPfgMMSSSmfqGIGKGLTSLIITILRELIFQVLFAY 402
|
330 340
....*....|....*....|....*....
gi 22326870 425 gvLLVYVFNFGIKGLWSGMLAGVGIQTLI 453
Cdd:cd13147 403 --LFAIVLGLGLFGVWWGIVLGNAIGSIV 429
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
32-239 |
7.31e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 48.34 E-value: 7.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 32 WSEVRKMWRIALPSTLFRVMSFGCVVVAQAFIGHSSETGLAAYAlLQSTFIRFIYGIMAGMSSATETLCGQAYGAEQYH- 110
Cdd:cd13142 233 WEWLKKIFRIGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYG-IGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDr 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 111 --------MMGIYLqrswiVDTFIATLFVPFivlAGPILRL-LGQNVVISETVD--EIYPWVIPYLYSIvftMTMQMYLQ 179
Cdd:cd13142 312 aeeivkkaALLIFL-----ILVIGGVLAFLF---AEPIVRVfINDPEVIKEGADflRIVAPSFPFFGLF---QVINGAFR 380
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22326870 180 AQMKNAIIGILSTLAL-VLDIAATWWCVSVMGMGIHGALLGLNISSWSVAIAEFVYVF-GGW 239
Cdd:cd13142 381 GSGHTLTAMIISILRLwVIRIPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKrGTW 442
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
32-238 |
1.08e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 47.91 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 32 WSEVRKMWRIALPSTLFRVMSFGCVVVAQAFIGHSSETGLAAYALLQSTFIrFIYGIMAGMSSATETLCGQAYGAEQYHM 111
Cdd:cd13133 227 RELLRRILRLGLPSGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINS-LAFLPMIGLGIAVSSLVGQALGAGRPDL 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 112 MGIYLQRS-WIVDTFIATLFVPFIVLAGPILRLLGQnvviSETVDEIYPWVIPYLY---SIVFTMTMQMYLQAQMKNA-- 185
Cdd:cd13133 306 AMRVTRRGlKLALAYMLLLGILFLLFPELLLSIFTP----GADFALIAELAVPLLRfvaAYILFDALALVFAGALRGAgd 381
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 22326870 186 --IIGILSTLALVLDIAATWWCVSVMGMGIHGALLGLNISSWSVAIAEFVYVFGG 238
Cdd:cd13133 382 trFVMLAELIVAWLYLLPPAYLLVVLGAGLAGAWTVETVYVIVLALIFLLRFRSG 436
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
129-440 |
2.14e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 43.76 E-value: 2.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 129 LFVPF-IVLAGPILRLLGQNVVISETVDEIYPWVIPYLYSIVFTMTMQMYLQAQ------MKNAIIGILstLALVLDIAA 201
Cdd:cd13144 100 LFLLLgLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTgntitpMIAQLIGAI--INIILDPIL 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 202 TWWCVSVMGMGIHGAllglnisswsvAIAefvyvfggwcphTWTGFSTAAFLDLIPMLKLSISSGFMLCLEYWYMSII-- 279
Cdd:cd13144 178 IFGLFGFPAMGIAGA-----------AIA------------TVIGQILAMFLAFFFLLRKNKDVQPDLRLFRPSLRIIke 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 280 ----------------VLMSG----YAKDANIAISAFSICQYIYSWEMNICFGLMGAACVRVANELGKGDADAVRFSIKV 339
Cdd:cd13144 235 iyavglpsiimqaissVMVFGlnkiLAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKY 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 340 VLVVSAVIGVICSALCLAFGGQISYLFSDSQAV-SDAVADLSIvLSISILFNIIQPILSGVAIGAG--MQSMValVNLAS 416
Cdd:cd13144 315 AILIAVVIMLAGGLLFQLFPDQLLGLFNASEEMlAIGVPALRI-ISLSFLFAALSIILSGLFQALGrgVYSLI--ISVAR 391
|
330 340
....*....|....*....|....
gi 22326870 417 YYAIGVPLGVLLVYVfnFGIKGLW 440
Cdd:cd13144 392 QLVVLLPLAWLLAKM--FGLNGVW 413
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
21-162 |
7.47e-04 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 41.85 E-value: 7.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 21 RRESLYLRKKIWSEVRKMWRIALPSTLFRVMSFGCVVVAQAFIGHSSETGLAAYALLqSTFIRFIYGIMAGMSSATETLC 100
Cdd:TIGR00797 201 GLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIA-LNVESLLFMPAFGFGIAVSILV 279
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22326870 101 GQAYGAEQYHMMGIYLQRSWIVdTFIATLFVPFIVLAGP--ILRLLGQNVVISETVDEIYPWVI 162
Cdd:TIGR00797 280 GQALGAGDPKRAKEVARVALKL-SLLLGLVLAIILILFRefIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_like_10 |
cd13125 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
327-463 |
1.38e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240530 [Multi-domain] Cd Length: 409 Bit Score: 40.99 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 327 KGDADAVRFSIKVVLVVSAVIGVICSALCLAFGGQIS-YLFSDSQAvsdavADLSIVLSISILFNIIQPILSGVAIGAGM 405
Cdd:cd13125 66 KDDEEKLARVWSTAFRITLILSILGGLLLLLFSKPLSsLLFGDIDY-----SWVFILLGLALPLFALNNLLLAILNGLKE 140
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 22326870 406 QSMVALVNLASYYaIGVPLGVLLVYvfNFGIKGLWSGMLAGVGIQTLILCYVIYKTDW 463
Cdd:cd13125 141 IKRYALINIISSL-IGLLVSVLLVY--FYGLKGALLALVLNQSLIFLVTLIYSRKQPW 195
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
312-456 |
5.11e-03 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 39.34 E-value: 5.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 312 GLMGAACVRVANELGKGDADAVRFSIKVVLVVSAVIGVICSALCLAFGGQISYLFSD-----SQAVSDAVADLSIVLSIS 386
Cdd:PRK00187 290 GLSYAVTMRVGQHYGAGRLLEARRAGRVGIGFGAVVMLLFAGLFWLLPEAIIGLFLDrndpaFAEIVQLAVSLLAVAAWF 369
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 387 ILFNIIQPILSGVAIGAGMQSMVALVNLASYYAIGVPLGVLLVYVFNFGIKGLWSGMLAGVGIQTLILCY 456
Cdd:PRK00187 370 ELFDGTQTIAMGAIRGLKDARTTFLIGLACYWLVGAPLAWLLAFTLGWGAVGVWWGLALGLACAAVALTL 439
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
20-235 |
7.70e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 38.73 E-value: 7.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 20 QRRESLYLRKKIWSEVRKMwriALPSTL-FRVMSFGCVVVaQAFIGHSSETGLAAYALlqSTFIRFIYGIMA-GMSSATE 97
Cdd:cd13145 221 CRLRDFIPRLDVYKEILKQ---GFPASLnMMTIGLGIFVI-TYFVGQFGDEAVAAYGI--ALRIEQILLLPTiGLNTAVL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22326870 98 TLCGQAYGAEQYHMMGIYLQRSWIVDTFIATLFVPFI-VLAGPILRLLGQNVVISET------VDEIYPWVIPYLYSIVF 170
Cdd:cd13145 295 SIAGQNFGAKKYDRVRETYKKALKYGFVIMVVATVFLlFFAEPLMSLFTNDPAVIAIgagylrIDALIFYAYVVLFISVS 374
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22326870 171 TmtmqmyLQAqMKNAIIGILSTLA--LVLDIAATWWCVSVMGMGIHGALLGLNISSWSVAIAEFVYV 235
Cdd:cd13145 375 V------LQG-LKRPIFALWIGLYrqLVGPALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIALLYT 434
|
|
| |
