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Conserved domains on  [gi|15238008|ref|NP_197270|]
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disease resistance protein (TIR-NBS-LRR class) [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03210 super family cl33662
Resistant to P. syringae 6; Provisional
 16-868 0e+00

Resistant to P. syringae 6; Provisional


The actual alignment was detected with superfamily member PLN03210:

Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 724.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008    16 WKTDVFVSFRGEDVRKTFVSHLFCEFDRMGIKAFRDDlDLQRGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLK 95
Cdd:PLN03210   11 WVYDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDN-EIERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWCLNELLE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008    96 IMECNKD---TIVPIFYEVDPSDVRRQRGSFGEDVES--HSDKEKVGK-WKEALKKLAAISGEDSRNWD-DSKLIKKIVK 168
Cdd:PLN03210   90 IVRCKEElgqLVIPVFYGLDPSHVRKQTGDFGEAFEKtcQNKTEDEKIqWKQALTDVANILGYHSQNWPnEAKMIEEIAN 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   169 DISDKLVSTSWDDSKGLIGMSSHMDFLQSMISIVDKDVRMLGIWGMGGVGKTTIAKYLYNQLSGQFQVHCFMENV----- 243
Cdd:PLN03210  170 DVLGKLNLTPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFIDRAfisks 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   244 KEVCNR-----YGVR-RLQVEFLCRMFQERDKEawssVSCCNIIKERFRHKMVFIVLDDVDRSEQLNELVKETGWFGPGS 317
Cdd:PLN03210  250 MEIYSSanpddYNMKlHLQRAFLSEILDKKDIK----IYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGS 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   318 RIIVTTRDRHLLLSHGINLVYKVkCLPKKE-ALQLFCNYAFREEIIlPHGFEELSVQAVNYASGLPLALRVLGSFLYRRS 396
Cdd:PLN03210  326 RIIVITKDKHFLRAHGIDHIYEV-CLPSNElALEMFCRSAFKKNSP-PDGFMELASEVALRAGNLPLGLNVLGSYLRGRD 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   397 QIEWESTLARLKTYPHSDIMEVLRVSYDGL-DEQEKAIFLYISCFYNMKQVDYVRKLLDLCGYAAEIGITILTEKSLIVE 475
Cdd:PLN03210  404 KEDWMDMLPRLRNGLDGKIEKTLRVSYDGLnNKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLIHV 483

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   476 SNGCVKIHDLLEQMGRELVRQQAvNNPAQRLLLWDPEDICHLLSENSGTQLVEGISLNLSEISEVFASDRAFEGLSNLKL 555
Cdd:PLN03210  484 REDIVEMHSLLQEMGKEIVRAQS-NEPGEREFLVDAKDICDVLEDNTGTKKVLGITLDIDEIDELHIHENAFKGMRNLLF 562

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   556 LNFYDLSFD--GETRVHLPNGLSYLPRKLRYLRWDGYPLKTMPSRFFPEFLVELCMSNSNLEKLWDGIQPLRNLKKMDLS 633
Cdd:PLN03210  563 LKFYTKKWDqkKEVRWHLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLR 642

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   634 RCKYLVEVPDLSKATNLEELNLSYCQSLVEVTPSIKNLKGLSCFYLTNCIQLKDIPIGIILKSLETVGMSGCSSLKHFPE 713
Cdd:PLN03210  643 GSKNLKEIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEILPTGINLKSLYRLNLSGCSRLKSFPD 722

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   714 ISWNTRRLYLSSTKIEELPSSIsRLSCLVKLDM-------------------------------SDCQRLRTLPSYLGHL 762
Cdd:PLN03210  723 ISTNISWLDLDETAIEEFPSNL-RLENLDELILcemkseklwervqpltplmtmlspsltrlflSDIPSLVELPSSIQNL 801

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   763 VSLKSLNLDGCRRLENLPdTLQNLTSLETLEVSGCLNVNEFPRVSTSIEVLRISETSIEEIPARICNLSQLRSLDISENK 842
Cdd:PLN03210  802 HKLEHLEIENCINLETLP-TGINLESLESLDLSGCSRLRTFPDISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGCN 880

                         890       900
                  ....*....|....*....|....*.
gi 15238008   843 RLASLPVSISELRSLEKLKLSGCSVL 868
Cdd:PLN03210  881 NLQRVSLNISKLKHLETVDFSDCGAL 906
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
762-1039 2.08e-32

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.59  E-value: 2.08e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  762 LVSLKSLNLDGCRRLENLPDTLQNLTSLETLEVSGCLNVNEFprvsTSIEVLRISETSIEEIPARICNLSQLRSLDISEN 841
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNN 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  842 KrLASLPVSISELRSLEKLKLSGCSvLESFPLEICQtMSCLRWFDLDRTSIKELPENIGNLVALEVLQASRTVIRRAPWS 921
Cdd:COG4886  147 Q-LTDLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGN-LTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  922 IARLTRLQVLAIGNSFFTPegllhslCPPLSRFDDLRALSLSNMNMTEIPNSiGNLWNLLELDLSGNNFEFIpaSIKRLT 1001
Cdd:COG4886  224 LANLTNLETLDLSNNQLTD-------LPELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDL--KLKELE 293

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 15238008 1002 RLNRLNLNNCQRLQALPDELPRGLLYIYIHSCTSLVSI 1039
Cdd:COG4886  294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
C-JID super family cl45530
C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron ...
 1083-1218 1.50e-09

C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron microscopy (cryoEM) structures of plant intracellular immune receptors containing Toll/interleukin-1 receptor (TIR, PF01582), nucleotide-binding (NB-ARC, PF00931) and leucine-rich repeat (LRR) domains (TIR-NLRs). Structurally, the C-JID core is represented by a beta-sandwich made up of 8 to 9 beta-strands. C-JID matches the so-called post LRR domain originally detected via a set of MEME motifs. The domain showed a strong distribution bias towards TIR-NLRs of dicotyledonous plant species despite broader taxonomic distribution of TIR-NLR in plant groups. Structure-function analyses of cryoEM structures suggest that C-JID domains play a role in substrate-recognition, such as binding to effector proteins from pathogens, and thus are involved in the initiation of signaling by TIR-NLR receptors. Presence of C-JID (or post-LRR) and its importance for the function of Arabidopsis TIR-NLR RPS4 that partners with RRS1 for effector recognition suggest that C-JID has additional functions.


The actual alignment was detected with superfamily member pfam20160:

Pssm-ID: 466313  Cd Length: 108  Bit Score: 56.69  E-value: 1.50e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   1083 FPGSDIPTCFNHQVMGPSLNIQLPQSESSSDILGFSACIMIGvdgqyPMNNLKIHCSCIlkdadaCELVVMDEVWYPDPK 1162
Cdd:pfam20160    1 LPGSQIPEWFNHQSTGSSISIKLPENWYNDNFLGFAVCAVGS-----LIPSLHNFLGYI------HFFLIPLVSLWDTSK 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 15238008   1163 AftNMYFGSDHLLLfsrtctsmeaysEALFEFSventegdsfSPLGEVKKCAVHLI 1218
Cdd:pfam20160   70 A--NGKTPNDYGRI------------EASFEFP---------SDLHEIKQCGVRLI 102
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 16-868 0e+00

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 724.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008    16 WKTDVFVSFRGEDVRKTFVSHLFCEFDRMGIKAFRDDlDLQRGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLK 95
Cdd:PLN03210   11 WVYDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDN-EIERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWCLNELLE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008    96 IMECNKD---TIVPIFYEVDPSDVRRQRGSFGEDVES--HSDKEKVGK-WKEALKKLAAISGEDSRNWD-DSKLIKKIVK 168
Cdd:PLN03210   90 IVRCKEElgqLVIPVFYGLDPSHVRKQTGDFGEAFEKtcQNKTEDEKIqWKQALTDVANILGYHSQNWPnEAKMIEEIAN 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   169 DISDKLVSTSWDDSKGLIGMSSHMDFLQSMISIVDKDVRMLGIWGMGGVGKTTIAKYLYNQLSGQFQVHCFMENV----- 243
Cdd:PLN03210  170 DVLGKLNLTPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFIDRAfisks 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   244 KEVCNR-----YGVR-RLQVEFLCRMFQERDKEawssVSCCNIIKERFRHKMVFIVLDDVDRSEQLNELVKETGWFGPGS 317
Cdd:PLN03210  250 MEIYSSanpddYNMKlHLQRAFLSEILDKKDIK----IYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGS 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   318 RIIVTTRDRHLLLSHGINLVYKVkCLPKKE-ALQLFCNYAFREEIIlPHGFEELSVQAVNYASGLPLALRVLGSFLYRRS 396
Cdd:PLN03210  326 RIIVITKDKHFLRAHGIDHIYEV-CLPSNElALEMFCRSAFKKNSP-PDGFMELASEVALRAGNLPLGLNVLGSYLRGRD 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   397 QIEWESTLARLKTYPHSDIMEVLRVSYDGL-DEQEKAIFLYISCFYNMKQVDYVRKLLDLCGYAAEIGITILTEKSLIVE 475
Cdd:PLN03210  404 KEDWMDMLPRLRNGLDGKIEKTLRVSYDGLnNKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLIHV 483

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   476 SNGCVKIHDLLEQMGRELVRQQAvNNPAQRLLLWDPEDICHLLSENSGTQLVEGISLNLSEISEVFASDRAFEGLSNLKL 555
Cdd:PLN03210  484 REDIVEMHSLLQEMGKEIVRAQS-NEPGEREFLVDAKDICDVLEDNTGTKKVLGITLDIDEIDELHIHENAFKGMRNLLF 562

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   556 LNFYDLSFD--GETRVHLPNGLSYLPRKLRYLRWDGYPLKTMPSRFFPEFLVELCMSNSNLEKLWDGIQPLRNLKKMDLS 633
Cdd:PLN03210  563 LKFYTKKWDqkKEVRWHLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLR 642

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   634 RCKYLVEVPDLSKATNLEELNLSYCQSLVEVTPSIKNLKGLSCFYLTNCIQLKDIPIGIILKSLETVGMSGCSSLKHFPE 713
Cdd:PLN03210  643 GSKNLKEIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEILPTGINLKSLYRLNLSGCSRLKSFPD 722

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   714 ISWNTRRLYLSSTKIEELPSSIsRLSCLVKLDM-------------------------------SDCQRLRTLPSYLGHL 762
Cdd:PLN03210  723 ISTNISWLDLDETAIEEFPSNL-RLENLDELILcemkseklwervqpltplmtmlspsltrlflSDIPSLVELPSSIQNL 801

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   763 VSLKSLNLDGCRRLENLPdTLQNLTSLETLEVSGCLNVNEFPRVSTSIEVLRISETSIEEIPARICNLSQLRSLDISENK 842
Cdd:PLN03210  802 HKLEHLEIENCINLETLP-TGINLESLESLDLSGCSRLRTFPDISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGCN 880

                         890       900
                  ....*....|....*....|....*.
gi 15238008   843 RLASLPVSISELRSLEKLKLSGCSVL 868
Cdd:PLN03210  881 NLQRVSLNISKLKHLETVDFSDCGAL 906
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 19-177 4.46e-60

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 203.37  E-value: 4.46e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008     19 DVFVSFRGEDVRKTFVSHLFCEFDRMGIKAFRDDLDLQRGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLKIME 98
Cdd:pfam01582    2 DVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKILE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008     99 CNKD---TIVPIFYEVDPSDVRRQRGSFGEDVESHS---DKEKVGKWKEALKKLAAIsgEDSRNWDD-SKLIKKIVKDIS 171
Cdd:pfam01582   82 CALDlgqKVIPIFYEVDPSDVRKQTGSFGKAFKKHKkvlTEEKVLKWRGALNEVANI--WHSKSVSDeSKFWKKIAYDIS 159


                   ....*.
gi 15238008    172 DKLVST 177
Cdd:pfam01582  160 NKLNGT 165
TIR smart00255
Toll - interleukin 1 - resistance;
19-149 1.06e-34

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 129.75  E-value: 1.06e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008      19 DVFVSFRG-EDVRKTFVSHLFCEFDRMGIKAFRDDLDLqrGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLKIM 97
Cdd:smart00255    3 DVFISYSGkEDVRNEFLSHLLEKLRGYGLCVFIDDFEP--GGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAAL 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008      98 EC----NKDTIVPIFYEVDPSDVRRQRGSFGEDVESH----SDKEKVGKWKEALKKLAAI 149
Cdd:smart00255   81 ENaleeGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKNylkwPEDEKEQFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
762-1039 2.08e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.59  E-value: 2.08e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  762 LVSLKSLNLDGCRRLENLPDTLQNLTSLETLEVSGCLNVNEFprvsTSIEVLRISETSIEEIPARICNLSQLRSLDISEN 841
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNN 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  842 KrLASLPVSISELRSLEKLKLSGCSvLESFPLEICQtMSCLRWFDLDRTSIKELPENIGNLVALEVLQASRTVIRRAPWS 921
Cdd:COG4886  147 Q-LTDLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGN-LTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  922 IARLTRLQVLAIGNSFFTPegllhslCPPLSRFDDLRALSLSNMNMTEIPNSiGNLWNLLELDLSGNNFEFIpaSIKRLT 1001
Cdd:COG4886  224 LANLTNLETLDLSNNQLTD-------LPELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDL--KLKELE 293

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 15238008 1002 RLNRLNLNNCQRLQALPDELPRGLLYIYIHSCTSLVSI 1039
Cdd:COG4886  294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
602-957 5.08e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.28  E-value: 5.08e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  602 EFLVELCMSNSNLEKLWDGIQPLRNLKKMDLSRCKylvevpDLSKATNLEELNLSYCQsLVEVTPSIKNLKGLSCFYLTN 681
Cdd:COG4886   73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQ-LTDLPEELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  682 CiQLKDIPIGIilksletvgmSGCSSLKHfpeiswntrrLYLSSTKIEELPSSISRLSCLVKLDMSDCQrLRTLPSYLGH 761
Cdd:COG4886  146 N-QLTDLPEPL----------GNLTNLKS----------LDLSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGN 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  762 LVSLKSLNLDGCrRLENLPDTLQNLTSLETLEVSGClNVNEFPRVS--TSIEVLRISETSIEEIPArICNLSQLRSLDIS 839
Cdd:COG4886  204 LTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNN-QLTDLPELGnlTNLEELDLSNNQLTDLPP-LANLTNLKTLDLS 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  840 ENkrlaslPVSISELRSLEKLKLSGCSVLESFPLEICQTMSCLRWFDLDRTSIKELPENIGNLVALEVLQASRTVIRRAP 919
Cdd:COG4886  281 NN------QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 15238008  920 WSIARLTRLQVLAIGNSFFTPEGLLHSLCPPLSRFDDL 957
Cdd:COG4886  355 LLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 715-1024 3.50e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.13  E-value: 3.50e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   715 SWNTRRLYLSSTKieeLPSSISR--LSCLVKLDMSDCQRLRTLPSYLGHLVSLKSLNLDGCRRLENLPDTLQNLTSLETL 792
Cdd:PLN00113  117 SSSLRYLNLSNNN---FTGSIPRgsIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFL 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   793 EVSGCLNVNEFPRVSTSIEVLRISETSIE----EIPARICNLSQLRSLDISENKRLASLPVSISELRSLEKLKLSGCSVL 868
Cdd:PLN00113  194 TLASNQLVGQIPRELGQMKSLKWIYLGYNnlsgEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   869 ESFPLEICqTMSCLRWFDLDRTSIK-ELPENIGNLVALEVLQA-SRTVIRRAPWSIARLTRLQVLAIGNSFFTPEgllhs 946
Cdd:PLN00113  274 GPIPPSIF-SLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLfSNNFTGKIPVALTSLPRLQVLQLWSNKFSGE----- 347

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   947 LCPPLSRFDDLRALSLSNMNMT-EIPNSIGNLWNLLELDLSGNNFEF-IPASIKRLTRLNRLNLNNcqrlQALPDELPRG 1024
Cdd:PLN00113  348 IPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQD----NSFSGELPSE 423
C-JID pfam20160
C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron ...
 1083-1218 1.50e-09

C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron microscopy (cryoEM) structures of plant intracellular immune receptors containing Toll/interleukin-1 receptor (TIR, PF01582), nucleotide-binding (NB-ARC, PF00931) and leucine-rich repeat (LRR) domains (TIR-NLRs). Structurally, the C-JID core is represented by a beta-sandwich made up of 8 to 9 beta-strands. C-JID matches the so-called post LRR domain originally detected via a set of MEME motifs. The domain showed a strong distribution bias towards TIR-NLRs of dicotyledonous plant species despite broader taxonomic distribution of TIR-NLR in plant groups. Structure-function analyses of cryoEM structures suggest that C-JID domains play a role in substrate-recognition, such as binding to effector proteins from pathogens, and thus are involved in the initiation of signaling by TIR-NLR receptors. Presence of C-JID (or post-LRR) and its importance for the function of Arabidopsis TIR-NLR RPS4 that partners with RRS1 for effector recognition suggest that C-JID has additional functions.


Pssm-ID: 466313  Cd Length: 108  Bit Score: 56.69  E-value: 1.50e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   1083 FPGSDIPTCFNHQVMGPSLNIQLPQSESSSDILGFSACIMIGvdgqyPMNNLKIHCSCIlkdadaCELVVMDEVWYPDPK 1162
Cdd:pfam20160    1 LPGSQIPEWFNHQSTGSSISIKLPENWYNDNFLGFAVCAVGS-----LIPSLHNFLGYI------HFFLIPLVSLWDTSK 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 15238008   1163 AftNMYFGSDHLLLfsrtctsmeaysEALFEFSventegdsfSPLGEVKKCAVHLI 1218
Cdd:pfam20160   70 A--NGKTPNDYGRI------------EASFEFP---------SDLHEIKQCGVRLI 102
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 702-867 3.35e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.56  E-value: 3.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  702 MSGCSSLKHfpeiswntrrLYLSSTKIeelpSSISRLSCLVKLDMSDCQ--RLRTLPSyLGHLVSLKSLNLDGCR--RLE 777
Cdd:cd21340   20 LSLCKNLKV----------LYLYDNKI----TKIENLEFLTNLTHLYLQnnQIEKIEN-LENLVNLKKLYLGGNRisVVE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  778 NLpdtlQNLTSLETLEVSG-------CLnvnEF-PR----VSTSIEVLRISETSIEEIpARICNLSQLRSLDISENK--R 843
Cdd:cd21340   85 GL----ENLTNLEELHIENqrlppgeKL---TFdPRslaaLSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQisD 156

                        170       180
                 ....*....|....*....|....
gi 15238008  844 LASLPVSISELRSLEKLKLSGCSV 867
Cdd:cd21340  157 LEELLDLLSSWPSLRELDLTGNPV 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 854-1011 2.42e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 2.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  854 LRSLEKLKLSGCSvLESFP-LEICQTMSCLRWFDLDRTSIkelpENIGNLVALEVLQASRTVIRRAPwSIARLTRLQVLA 932
Cdd:cd21340    1 LKRITHLYLNDKN-ITKIDnLSLCKNLKVLYLYDNKITKI----ENLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  933 IG-NSFFTPEGL--------LH----SLCPPLS-RFDD---------LRALSLSNMNMTEIpNSIGNLWNLLELDLSGN- 988
Cdd:cd21340   75 LGgNRISVVEGLenltnleeLHienqRLPPGEKlTFDPrslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNq 153

                        170       180
                 ....*....|....*....|....*
gi 15238008  989 --NFEFIPASIKRLTRLNRLNLNNC 1011
Cdd:cd21340  154 isDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
957-1012 7.13e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 7.13e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 15238008    957 LRALSLSNMNMTEI-PNSIGNLWNLLELDLSGNNFEFI-PASIKRLTRLNRLNLNNCQ 1012
Cdd:pfam13855    3 LRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
 
Name Accession Description Interval E-value
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 16-868 0e+00

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 724.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008    16 WKTDVFVSFRGEDVRKTFVSHLFCEFDRMGIKAFRDDlDLQRGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLK 95
Cdd:PLN03210   11 WVYDVFPSFSGEDVRITFLSHFLKELDRKLIIAFKDN-EIERSQSLDPELKQAIRDSRIAVVVFSKNYASSSWCLNELLE 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008    96 IMECNKD---TIVPIFYEVDPSDVRRQRGSFGEDVES--HSDKEKVGK-WKEALKKLAAISGEDSRNWD-DSKLIKKIVK 168
Cdd:PLN03210   90 IVRCKEElgqLVIPVFYGLDPSHVRKQTGDFGEAFEKtcQNKTEDEKIqWKQALTDVANILGYHSQNWPnEAKMIEEIAN 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   169 DISDKLVSTSWDDSKGLIGMSSHMDFLQSMISIVDKDVRMLGIWGMGGVGKTTIAKYLYNQLSGQFQVHCFMENV----- 243
Cdd:PLN03210  170 DVLGKLNLTPSNDFEDFVGIEDHIAKMSSLLHLESEEVRMVGIWGSSGIGKTTIARALFSRLSRQFQSSVFIDRAfisks 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   244 KEVCNR-----YGVR-RLQVEFLCRMFQERDKEawssVSCCNIIKERFRHKMVFIVLDDVDRSEQLNELVKETGWFGPGS 317
Cdd:PLN03210  250 MEIYSSanpddYNMKlHLQRAFLSEILDKKDIK----IYHLGAMEERLKHRKVLIFIDDLDDQDVLDALAGQTQWFGSGS 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   318 RIIVTTRDRHLLLSHGINLVYKVkCLPKKE-ALQLFCNYAFREEIIlPHGFEELSVQAVNYASGLPLALRVLGSFLYRRS 396
Cdd:PLN03210  326 RIIVITKDKHFLRAHGIDHIYEV-CLPSNElALEMFCRSAFKKNSP-PDGFMELASEVALRAGNLPLGLNVLGSYLRGRD 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   397 QIEWESTLARLKTYPHSDIMEVLRVSYDGL-DEQEKAIFLYISCFYNMKQVDYVRKLLDLCGYAAEIGITILTEKSLIVE 475
Cdd:PLN03210  404 KEDWMDMLPRLRNGLDGKIEKTLRVSYDGLnNKKDKAIFRHIACLFNGEKVNDIKLLLANSDLDVNIGLKNLVDKSLIHV 483

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   476 SNGCVKIHDLLEQMGRELVRQQAvNNPAQRLLLWDPEDICHLLSENSGTQLVEGISLNLSEISEVFASDRAFEGLSNLKL 555
Cdd:PLN03210  484 REDIVEMHSLLQEMGKEIVRAQS-NEPGEREFLVDAKDICDVLEDNTGTKKVLGITLDIDEIDELHIHENAFKGMRNLLF 562

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   556 LNFYDLSFD--GETRVHLPNGLSYLPRKLRYLRWDGYPLKTMPSRFFPEFLVELCMSNSNLEKLWDGIQPLRNLKKMDLS 633
Cdd:PLN03210  563 LKFYTKKWDqkKEVRWHLPEGFDYLPPKLRLLRWDKYPLRCMPSNFRPENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLR 642

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   634 RCKYLVEVPDLSKATNLEELNLSYCQSLVEVTPSIKNLKGLSCFYLTNCIQLKDIPIGIILKSLETVGMSGCSSLKHFPE 713
Cdd:PLN03210  643 GSKNLKEIPDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCENLEILPTGINLKSLYRLNLSGCSRLKSFPD 722

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   714 ISWNTRRLYLSSTKIEELPSSIsRLSCLVKLDM-------------------------------SDCQRLRTLPSYLGHL 762
Cdd:PLN03210  723 ISTNISWLDLDETAIEEFPSNL-RLENLDELILcemkseklwervqpltplmtmlspsltrlflSDIPSLVELPSSIQNL 801

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   763 VSLKSLNLDGCRRLENLPdTLQNLTSLETLEVSGCLNVNEFPRVSTSIEVLRISETSIEEIPARICNLSQLRSLDISENK 842
Cdd:PLN03210  802 HKLEHLEIENCINLETLP-TGINLESLESLDLSGCSRLRTFPDISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGCN 880

                         890       900
                  ....*....|....*....|....*.
gi 15238008   843 RLASLPVSISELRSLEKLKLSGCSVL 868
Cdd:PLN03210  881 NLQRVSLNISKLKHLETVDFSDCGAL 906
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 19-177 4.46e-60

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 203.37  E-value: 4.46e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008     19 DVFVSFRGEDVRKTFVSHLFCEFDRMGIKAFRDDLDLQRGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLKIME 98
Cdd:pfam01582    2 DVFLSFRGSDTREWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKILE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008     99 CNKD---TIVPIFYEVDPSDVRRQRGSFGEDVESHS---DKEKVGKWKEALKKLAAIsgEDSRNWDD-SKLIKKIVKDIS 171
Cdd:pfam01582   82 CALDlgqKVIPIFYEVDPSDVRKQTGSFGKAFKKHKkvlTEEKVLKWRGALNEVANI--WHSKSVSDeSKFWKKIAYDIS 159


                   ....*.
gi 15238008    172 DKLVST 177
Cdd:pfam01582  160 NKLNGT 165
TIR smart00255
Toll - interleukin 1 - resistance;
19-149 1.06e-34

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 129.75  E-value: 1.06e-34
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008      19 DVFVSFRG-EDVRKTFVSHLFCEFDRMGIKAFRDDLDLqrGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLKIM 97
Cdd:smart00255    3 DVFISYSGkEDVRNEFLSHLLEKLRGYGLCVFIDDFEP--GGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVAAL 80

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008      98 EC----NKDTIVPIFYEVDPSDVRRQRGSFGEDVESH----SDKEKVGKWKEALKKLAAI 149
Cdd:smart00255   81 ENaleeGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKNylkwPEDEKEQFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
762-1039 2.08e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.59  E-value: 2.08e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  762 LVSLKSLNLDGCRRLENLPDTLQNLTSLETLEVSGCLNVNEFprvsTSIEVLRISETSIEEIPARICNLSQLRSLDISEN 841
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNN 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  842 KrLASLPVSISELRSLEKLKLSGCSvLESFPLEICQtMSCLRWFDLDRTSIKELPENIGNLVALEVLQASRTVIRRAPWS 921
Cdd:COG4886  147 Q-LTDLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGN-LTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  922 IARLTRLQVLAIGNSFFTPegllhslCPPLSRFDDLRALSLSNMNMTEIPNSiGNLWNLLELDLSGNNFEFIpaSIKRLT 1001
Cdd:COG4886  224 LANLTNLETLDLSNNQLTD-------LPELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDL--KLKELE 293

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 15238008 1002 RLNRLNLNNCQRLQALPDELPRGLLYIYIHSCTSLVSI 1039
Cdd:COG4886  294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
602-957 5.08e-30

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.28  E-value: 5.08e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  602 EFLVELCMSNSNLEKLWDGIQPLRNLKKMDLSRCKylvevpDLSKATNLEELNLSYCQsLVEVTPSIKNLKGLSCFYLTN 681
Cdd:COG4886   73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQ-LTDLPEELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  682 CiQLKDIPIGIilksletvgmSGCSSLKHfpeiswntrrLYLSSTKIEELPSSISRLSCLVKLDMSDCQrLRTLPSYLGH 761
Cdd:COG4886  146 N-QLTDLPEPL----------GNLTNLKS----------LDLSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGN 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  762 LVSLKSLNLDGCrRLENLPDTLQNLTSLETLEVSGClNVNEFPRVS--TSIEVLRISETSIEEIPArICNLSQLRSLDIS 839
Cdd:COG4886  204 LTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNN-QLTDLPELGnlTNLEELDLSNNQLTDLPP-LANLTNLKTLDLS 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  840 ENkrlaslPVSISELRSLEKLKLSGCSVLESFPLEICQTMSCLRWFDLDRTSIKELPENIGNLVALEVLQASRTVIRRAP 919
Cdd:COG4886  281 NN------QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 15238008  920 WSIARLTRLQVLAIGNSFFTPEGLLHSLCPPLSRFDDL 957
Cdd:COG4886  355 LLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
611-985 3.74e-29

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 121.96  E-value: 3.74e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  611 NSNLEKLWDGIQPLRNLKKMDLSRCKYLVEVPDLSKATNLEELNLSYCQSlvevtpsIKNLKGLSCFYLTNCiQLKDIPI 690
Cdd:COG4886   59 DLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGN-QLTDLPE 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  691 GIilksletvgmSGCSSLKHfpeiswntrrLYLSSTKIEELPSSISRLSCLVKLDMSDCQrLRTLPSYLGHLVSLKSLNL 770
Cdd:COG4886  131 EL----------ANLTNLKE----------LDLSNNQLTDLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKELDL 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  771 DGCrRLENLPDTLQNLTSLETLEVSGClNVNEFPRV---STSIEVLRISETSIEEIPArICNLSQLRSLDISENKrLASL 847
Cdd:COG4886  190 SNN-QITDLPEPLGNLTNLEELDLSGN-QLTDLPEPlanLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQ-LTDL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  848 PvSISELRSLEKLKLSGCSvLESFPLEICQTMSCLRWFDLDRTSIKELPENIGNLVALEVLQASRTVIRRAPWSIARLTR 927
Cdd:COG4886  266 P-PLANLTNLKTLDLSNNQ-LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15238008  928 LQVLAIGNSFFTPEGLLHSLCPPLSRFDDLRALSLSNMNMTEIPNSIGNLWNLLELDL 985
Cdd:COG4886  344 LSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
776-1055 3.68e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.94  E-value: 3.68e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  776 LENLPDTLQNLTSLETLEVSGCLNVNEFPRVSTSIEVLRISETSIEEIPARICNLSQLRSLDISENKRLASLPVSISELR 855
Cdd:COG4886   17 LLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLT 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  856 SLEKLKLSGCSVLESFpleicqtmSCLRWFDLDRTSIKELPENIGNLVALEVLQASRTVIRRAPWSIARLTRLQVLAIGN 935
Cdd:COG4886   97 NLTELDLSGNEELSNL--------TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  936 SfftpegLLHSLCPPLSRFDDLRALSLSNMNMTEIPNSIGNLWNLLELDLSGNNFEFIPASIKRLTRLNRLNLNNCQrLQ 1015
Cdd:COG4886  169 N------QLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQ-LT 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 15238008 1016 ALPD--ELPRgLLYIYIHScTSLVSISGCFNQYCLRKLVASN 1055
Cdd:COG4886  242 DLPElgNLTN-LEELDLSN-NQLTDLPPLANLTNLKTLDLSN 281
NB-ARC pfam00931
NB-ARC domain;
205-424 5.10e-21

NB-ARC domain;


Pssm-ID: 395745 [Multi-domain]  Cd Length: 245  Bit Score: 93.60  E-value: 5.10e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008    205 DVRMLGIWGMGGVGKTTIAKYLYN---QLSGQFQVHCFMENVKEvcnrYGVRRLQVEFLCRMFQERDKeaWSSVSCCNI- 280
Cdd:pfam00931   17 EPGIVGIHGMGGVGKTTLAAQIFNdfdEVEGHFDSVAWVVVSKT----FTISTLQQTILQNLGLSEDD--WDNKEEGELa 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008    281 --IKERFRHKMVFIVLDDVDRSEQLNELVKETGWFGPGSRIIVTTRDRHLLLSHG-INLVYKVKCLPKKEALQLFCNYAF 357
Cdd:pfam00931   91 rkIRRALLTKRFLLVLDDVWDEEDWDKIGIPLPDRENGCRVLLTTRSEEVAGRVGgPSDPHEVELLEPDEAWELFENKVF 170

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15238008    358 REEIILPHGFEELSVQAVNYASGLPLALRVLGSFLYRRSQI-EWE------STLARLKTYPHSDIMEVLRVSYD 424
Cdd:pfam00931  171 PKTLGECELLEDVAKEIVEKCRGLPLALKVLGGLLSCKKTVeEWKhvydvlQSELKSNSYSLNSVRSILQLSYE 244
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 20-115 2.76e-16

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 76.20  E-value: 2.76e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008     20 VFVSFRGEDvrKTFVSHLFCEFDRMGIKAFRDDLDLQRGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLKIMEC 99
Cdd:pfam13676    1 VFISYAGED--RAWAEWLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALAD 78

                           90
                   ....*....|....*...
gi 15238008    100 --NKDTIVPIFYEVDPSD 115
Cdd:pfam13676   79 peGRKRLIPVRLECDLEL 96
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 715-1024 3.50e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.13  E-value: 3.50e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   715 SWNTRRLYLSSTKieeLPSSISR--LSCLVKLDMSDCQRLRTLPSYLGHLVSLKSLNLDGCRRLENLPDTLQNLTSLETL 792
Cdd:PLN00113  117 SSSLRYLNLSNNN---FTGSIPRgsIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFL 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   793 EVSGCLNVNEFPRVSTSIEVLRISETSIE----EIPARICNLSQLRSLDISENKRLASLPVSISELRSLEKLKLSGCSVL 868
Cdd:PLN00113  194 TLASNQLVGQIPRELGQMKSLKWIYLGYNnlsgEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   869 ESFPLEICqTMSCLRWFDLDRTSIK-ELPENIGNLVALEVLQA-SRTVIRRAPWSIARLTRLQVLAIGNSFFTPEgllhs 946
Cdd:PLN00113  274 GPIPPSIF-SLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLfSNNFTGKIPVALTSLPRLQVLQLWSNKFSGE----- 347

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   947 LCPPLSRFDDLRALSLSNMNMT-EIPNSIGNLWNLLELDLSGNNFEF-IPASIKRLTRLNRLNLNNcqrlQALPDELPRG 1024
Cdd:PLN00113  348 IPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQD----NSFSGELPSE 423
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
835-1021 4.45e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.13  E-value: 4.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  835 SLDISENKRLASLPVSISELRSLEKLKLSGCSVLESFPLEICQTMSCLRWFDLDRTSIKELPENIGNLVALEVLQASRTV 914
Cdd:COG4886    5 LLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  915 IRRAPWSIARLTRLQVLAIGNsfftpegllhslCPPLSRFDDLRALSLSNMNMTEIPNSIGNLWNLLELDLSGNNFEFIP 994
Cdd:COG4886   85 LLLGLTDLGDLTNLTELDLSG------------NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLP 152

                        170       180
                 ....*....|....*....|....*..
gi 15238008  995 ASIKRLTRLNRLNLNNCQrLQALPDEL 1021
Cdd:COG4886  153 EPLGNLTNLKSLDLSNNQ-LTDLPEEL 178
PLN03194 PLN03194
putative disease resistance protein; Provisional
 19-117 1.88e-13

putative disease resistance protein; Provisional


Pssm-ID: 215626 [Multi-domain]  Cd Length: 187  Bit Score: 70.24  E-value: 1.88e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008    19 DVFVSFRGEDVRKTFVSHLFCEFDRMGIKAFRDDLDLQRGKSISPELIDAIKGSRFAIVVVSRNYAASSWCLDELLKIME 98
Cdd:PLN03194   28 DVFINHRGIDTKRTIATLLYDHLSRLNLRPFLDNKNMKPGDKLFDKINSAIRNCKVGVAVFSPRYCESYFCLHELALIME 107

                          90
                  ....*....|....*....
gi 15238008    99 cNKDTIVPIFYEVDPSDVR 117
Cdd:PLN03194  108 -SKKRVIPIFCDVKPSQLR 125
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 498-1022 3.01e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 74.88  E-value: 3.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   498 AVNNPAQRLLLWDPE-DICH---LLSENSGTqlVEGISLNLSEISEVFASdrAFEGLSNLKLLNFYDLSFDGEtrvhLPN 573
Cdd:PLN00113   40 SINDPLKYLSNWNSSaDVCLwqgITCNNSSR--VVSIDLSGKNISGKISS--AIFRLPYIQTINLSNNQLSGP----IPD 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   574 GLSYLPRKLRYLRWDGYPLK-TMPSRFFPeFLVELCMSNSNLE-KLWDGIQPLRNLKKMDLSRCKYLVEVP-DLSKATNL 650
Cdd:PLN00113  112 DIFTTSSSLRYLNLSNNNFTgSIPRGSIP-NLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKIPnSLTNLTSL 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   651 EELNLSYCQSLVEVTPSIKNLKGLSCFYLTNCIQLKDIPIGI----ILKSLETV--GMSGC--SSLKHFPEISWntrrLY 722
Cdd:PLN00113  191 EFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIggltSLNHLDLVynNLTGPipSSLGNLKNLQY----LF 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   723 LSSTKIE-ELPSSISRLSCLVKLDMSDCQRLRTLPSYLGHLVSLKSLNLDGCRRLENLPDTLQNLTSLETLEVSGCLNVN 801
Cdd:PLN00113  267 LYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSG 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   802 EFPR---VSTSIEVLRISETSIE-EIPARICNLSQLRSLDISENKRLASLPVSISELRSLEKLKLSGCSVLESFPLEICQ 877
Cdd:PLN00113  347 EIPKnlgKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTK 426

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   878 tMSCLRWFDLDRTSIKelpeniGNlvalevlqasrtvIRRAPWSiarLTRLQVLAIG-NSFFtpeGLLhslcPPLSRFDD 956
Cdd:PLN00113  427 -LPLVYFLDISNNNLQ------GR-------------INSRKWD---MPSLQMLSLArNKFF---GGL----PDSFGSKR 476

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15238008   957 LRALSLSNMNMTE-IPNSIGNLWNLLELDLSGNNFE-FIPASIKRLTRLNRLNLNNCQRLQALPD---ELP 1022
Cdd:PLN00113  477 LENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPAsfsEMP 547
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
504-704 7.35e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 7.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  504 QRLLLWDPEDICHL-------LSENSGTQLVEGISlNLSEISEVFASD-------RAFEGLSNLKLLNFYDlsfdgetrv 569
Cdd:COG4886   99 TELDLSGNEELSNLtnlesldLSGNQLTDLPEELA-NLTNLKELDLSNnqltdlpEPLGNLTNLKSLDLSN--------- 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  570 hlpNGLSYLPRklrylrwdgyPLKTMPSrffpefLVELCMSNSNLEKLWDGIQPLRNLKKMDLSRCKyLVEVPD-LSKAT 648
Cdd:COG4886  169 ---NQLTDLPE----------ELGNLTN------LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQ-LTDLPEpLANLT 228

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 15238008  649 NLEELNLSYCQslVEVTPSIKNLKGLSCFYLTNCiQLKDIPIGIILKSLETVGMSG 704
Cdd:COG4886  229 NLETLDLSNNQ--LTDLPELGNLTNLEELDLSNN-QLTDLPPLANLTNLKTLDLSN 281
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
706-922 1.54e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.87  E-value: 1.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   706 SSLKHFPE-ISWNTRRLYLSSTKIEELPSSISRLSCLVKLDMSdcqRLRTLPSYLGHlvSLKSLNLdGCRRLENLPDTLQ 784
Cdd:PRK15370  209 NELKSLPEnLQGNIKTLYANSNQLTSIPATLPDTIQEMELSIN---RITELPERLPS--ALQSLDL-FHNKISCLPENLP 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   785 NltSLETLEVSGClNVNEFP-RVSTSIEVLRISETSIEEIPARICnlSQLRSLDISENKrLASLPVSIS-ELRSLEkLKL 862
Cdd:PRK15370  283 E--ELRYLSVYDN-SIRTLPaHLPSGITHLNVQSNSLTALPETLP--PGLKTLEAGENA-LTSLPASLPpELQVLD-VSK 355

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15238008   863 SGCSVL-ESFPLEIcQTMsclrwfDLDRTSIKELPENIGnlVALEVLQASRTVIRRAPWSI 922
Cdd:PRK15370  356 NQITVLpETLPPTI-TTL------DVSRNALTNLPENLP--AALQIMQASRNNLVRLPESL 407
C-JID pfam20160
C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron ...
 1083-1218 1.50e-09

C-JID domain; C-terminal jelly roll/Ig-like domain (C-JID) was defined in cryogenic electron microscopy (cryoEM) structures of plant intracellular immune receptors containing Toll/interleukin-1 receptor (TIR, PF01582), nucleotide-binding (NB-ARC, PF00931) and leucine-rich repeat (LRR) domains (TIR-NLRs). Structurally, the C-JID core is represented by a beta-sandwich made up of 8 to 9 beta-strands. C-JID matches the so-called post LRR domain originally detected via a set of MEME motifs. The domain showed a strong distribution bias towards TIR-NLRs of dicotyledonous plant species despite broader taxonomic distribution of TIR-NLR in plant groups. Structure-function analyses of cryoEM structures suggest that C-JID domains play a role in substrate-recognition, such as binding to effector proteins from pathogens, and thus are involved in the initiation of signaling by TIR-NLR receptors. Presence of C-JID (or post-LRR) and its importance for the function of Arabidopsis TIR-NLR RPS4 that partners with RRS1 for effector recognition suggest that C-JID has additional functions.


Pssm-ID: 466313  Cd Length: 108  Bit Score: 56.69  E-value: 1.50e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   1083 FPGSDIPTCFNHQVMGPSLNIQLPQSESSSDILGFSACIMIGvdgqyPMNNLKIHCSCIlkdadaCELVVMDEVWYPDPK 1162
Cdd:pfam20160    1 LPGSQIPEWFNHQSTGSSISIKLPENWYNDNFLGFAVCAVGS-----LIPSLHNFLGYI------HFFLIPLVSLWDTSK 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 15238008   1163 AftNMYFGSDHLLLfsrtctsmeaysEALFEFSventegdsfSPLGEVKKCAVHLI 1218
Cdd:pfam20160   70 A--NGKTPNDYGRI------------EASFEFP---------SDLHEIKQCGVRLI 102
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 702-867 3.35e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.56  E-value: 3.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  702 MSGCSSLKHfpeiswntrrLYLSSTKIeelpSSISRLSCLVKLDMSDCQ--RLRTLPSyLGHLVSLKSLNLDGCR--RLE 777
Cdd:cd21340   20 LSLCKNLKV----------LYLYDNKI----TKIENLEFLTNLTHLYLQnnQIEKIEN-LENLVNLKKLYLGGNRisVVE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  778 NLpdtlQNLTSLETLEVSG-------CLnvnEF-PR----VSTSIEVLRISETSIEEIpARICNLSQLRSLDISENK--R 843
Cdd:cd21340   85 GL----ENLTNLEELHIENqrlppgeKL---TFdPRslaaLSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQisD 156

                        170       180
                 ....*....|....*....|....
gi 15238008  844 LASLPVSISELRSLEKLKLSGCSV 867
Cdd:cd21340  157 LEELLDLLSSWPSLRELDLTGNPV 180
COG4916 COG4916
Uncharacterized conserved protein [Function unknown];
19-156 7.74e-08

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443944 [Multi-domain]  Cd Length: 236  Bit Score: 54.73  E-value: 7.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   19 DVFVSFRGEDvrKTFVSHLFCEFDRMGIKAFRDDLDLQR--GKSISPELIDAIKG-SRFAIVVVSRNYAASSWCLDELL- 94
Cdd:COG4916    2 DVALSFAGED--REFVERVAEALKARGIKVFYDENEEAElwGKDLDEYLQDIYRSeSRFVVVFLSKDYVEKKWTGLERRa 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15238008   95 ---KIMECNKDTIVPIFY-EVDPSDVRRQRGSFgeDVESHSDKEKVgkwKEALKKLAAISGEDSRN 156
Cdd:COG4916   80 alaRAMQRKKEYILPIRLdDTEIPGILATIGYI--DLRNRTPEEIA---DLILEKLAKGRPKPSRA 140
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 601-863 8.40e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.78  E-value: 8.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   601 PEFLVEL-------CMSNSNLEKLWDGIQPLRNLKKMDLSRCKYLVEVP-DLSKATNLEELNLSyCQSLVEVTPsiknlK 672
Cdd:PLN00113  301 PELVIQLqnleilhLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPkNLGKHNNLTVLDLS-TNNLTGEIP-----E 374

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   673 GL-SCFYLTNCIQLKDIPIGIILKSLetvgmSGCSSLkhfpeiswntRRLYLSSTKIE-ELPSSISRLSCLVKLDMSDCQ 750
Cdd:PLN00113  375 GLcSSGNLFKLILFSNSLEGEIPKSL-----GACRSL----------RRVRLQDNSFSgELPSEFTKLPLVYFLDISNNN 439

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   751 RLRTLPSYLGHLVSLKSLNLDGCRRLENLPDTLQNlTSLETLEVSGCLNVNEFPRVSTS---IEVLRISETSIE-EIPAR 826
Cdd:PLN00113  440 LQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSlseLMQLKLSENKLSgEIPDE 518

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 15238008   827 ICNLSQLRSLDISENKRLASLPVSISELRSLEKLKLS 863
Cdd:PLN00113  519 LSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLS 555
PLN03150 PLN03150
hypothetical protein; Provisional
 941-1009 8.84e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 53.28  E-value: 8.84e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15238008   941 EGLLHSLCPPLSRFDDLRALSLSNMNMT-EIPNSIGNLWNLLELDLSGNNFE-FIPASIKRLTRLNRLNLN 1009
Cdd:PLN03150  428 QGLRGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLN 498
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 552-782 4.02e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 4.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   552 NLKLLNFYDLSFDGEtrvhLPNGLSYLpRKLRYLRWDGYPLK-TMPSRFFPEFLVE-LCMSNSNLE-----KLWDgiqpL 624
Cdd:PLN00113  381 NLFKLILFSNSLEGE----IPKSLGAC-RSLRRVRLQDNSFSgELPSEFTKLPLVYfLDISNNNLQgrinsRKWD----M 451

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   625 RNLKKMDLSRCKYLVEVPDLSKATNLEELNLSYCQSLVEVTPSIKNLKGLSCFYLTNCIQLKDIPigiilksletVGMSG 704
Cdd:PLN00113  452 PSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIP----------DELSS 521

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15238008   705 CSSLKHfpeiswntrrLYLSSTKIE-ELPSSISRLSCLVKLDMSDCQRLRTLPSYLGHLVSLKSLNLDGCRRLENLPDT 782
Cdd:PLN00113  522 CKKLVS----------LDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPST 590
LRR_3 pfam07725
Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the ...
 603-622 5.09e-04

Leucine Rich Repeat; This Pfam entry includes some LRRs that fail to be detected by the pfam00560 model.


Pssm-ID: 429621 [Multi-domain]  Cd Length: 20  Bit Score: 38.47  E-value: 5.09e-04
                           10        20
                   ....*....|....*....|
gi 15238008    603 FLVELCMSNSNLEKLWDGIQ 622
Cdd:pfam07725    1 NLVELNMPYSKLEKLWEGVK 20
PLN03150 PLN03150
hypothetical protein; Provisional
 810-867 8.57e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 8.57e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 15238008   810 IEVLRISETSIE-EIPARICNLSQLRSLDISENKRLASLPVSISELRSLEKLKLSGCSV 867
Cdd:PLN03150  444 LQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 530-848 1.26e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   530 ISLNLS------EISEVFASdrafegLSNLKLLNFYDLSFDGEtrvhLPNGLSYLPRkLRYLR-WDgyplktmpSRFFPE 602
Cdd:PLN00113  287 ISLDLSdnslsgEIPELVIQ------LQNLEILHLFSNNFTGK----IPVALTSLPR-LQVLQlWS--------NKFSGE 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   603 FLVELCMSNsnleklwdgiqplrNLKKMDLSRCKYLVEVPD-LSKATNLEELNLsYCQSLV-EVTPSiknlkglscfyLT 680
Cdd:PLN00113  348 IPKNLGKHN--------------NLTVLDLSTNNLTGEIPEgLCSSGNLFKLIL-FSNSLEgEIPKS-----------LG 401

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   681 NCIQLKDIpigiilkSLETVGMSGCSS-------LKHFPEISWNTRRLYLSSTKIE----------------ELPSSiSR 737
Cdd:PLN00113  402 ACRSLRRV-------RLQDNSFSGELPseftklpLVYFLDISNNNLQGRINSRKWDmpslqmlslarnkffgGLPDS-FG 473

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008   738 LSCLVKLDMSDCQRLRTLPSYLGHLVSLKSLNLDGCRRLENLPDTLQNLTSLETLEVSGCLNVNEFPRVSTSIEVLRISE 817
Cdd:PLN00113  474 SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLD 553

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 15238008   818 TSIE----EIPARICNLSQLRSLDISENKRLASLP 848
Cdd:PLN00113  554 LSQNqlsgEIPKNLGNVESLVQVNISHNHLHGSLP 588
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
885-1056 1.98e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 1.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  885 FDLDRTSIKELPENIGNLVALEVLQASRTVIRRAPWSIARLTRLQVLAIGNSFFTPEGLLHSLCPPLSRFDDLRALSLSN 964
Cdd:COG4886    3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  965 MNMTEIPNSIGNLWNLLELD-----------------LSGNNFEFIPASIKRLTRLNRLNLNNCQrLQALPDELPR--GL 1025
Cdd:COG4886   83 SLLLLGLTDLGDLTNLTELDlsgneelsnltnlesldLSGNQLTDLPEELANLTNLKELDLSNNQ-LTDLPEPLGNltNL 161

                        170       180       190
                 ....*....|....*....|....*....|....
gi 15238008 1026 LYIYIHSC--TSL-VSISGCFNqycLRKLVASNC 1056
Cdd:COG4886  162 KSLDLSNNqlTDLpEELGNLTN---LKELDLSNN 192
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 854-1011 2.42e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 2.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  854 LRSLEKLKLSGCSvLESFP-LEICQTMSCLRWFDLDRTSIkelpENIGNLVALEVLQASRTVIRRAPwSIARLTRLQVLA 932
Cdd:cd21340    1 LKRITHLYLNDKN-ITKIDnLSLCKNLKVLYLYDNKITKI----ENLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15238008  933 IG-NSFFTPEGL--------LH----SLCPPLS-RFDD---------LRALSLSNMNMTEIpNSIGNLWNLLELDLSGN- 988
Cdd:cd21340   75 LGgNRISVVEGLenltnleeLHienqRLPPGEKlTFDPrslaalsnsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNq 153

                        170       180
                 ....*....|....*....|....*
gi 15238008  989 --NFEFIPASIKRLTRLNRLNLNNC 1011
Cdd:cd21340  154 isDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
957-1012 7.13e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 7.13e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 15238008    957 LRALSLSNMNMTEI-PNSIGNLWNLLELDLSGNNFEFI-PASIKRLTRLNRLNLNNCQ 1012
Cdd:pfam13855    3 LRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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