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Conserved domains on  [gi|15237304|ref|NP_197126|]
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Octicosapeptide/Phox/Bem1p family protein [Arabidopsis thaliana]

Protein Classification

PB1 domain-containing protein( domain architecture ID 10157399)

PB1 domain-containing protein may mediate specific protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PB1_UP2 cd06410
Uncharacterized protein 2. The PB1 domain is a modular domain mediating specific ...
 34-136 1.19e-40

Uncharacterized protein 2. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in many critical cell processes such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions.


:

Pssm-ID: 99731  Cd Length: 97  Bit Score: 140.82  E-value: 1.19e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237304  34 MCRYGGSIVSPPQTKSPRYVGGDTRIVAIPSSaeTSFASLVSHLTVTLKISYPFKVKYQLPDQELDSLISVEADEDVQIM 113
Cdd:cd06410   1 LCSYGGRILPRPPDGQLRYVGGETRIVSVDRS--ISFKELVSKLSELFGAGVVVTLKYQLPDEDLDALISVSNDEDLKNM 78

                        90       100
                ....*....|....*....|...
gi 15237304 114 MEEHGYLSSESsipqSRIRLFLF 136
Cdd:cd06410  79 MEEYDRLSGGS----ARLRVFLF 97
PRK10263 super family cl35903
DNA translocase FtsK; Provisional
 261-470 2.06e-03

DNA translocase FtsK; Provisional


The actual alignment was detected with superfamily member PRK10263:

Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.84  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237304   261 SQVKFAPIESVTSNdnsavTPIPSHELPSHSHAFENKPSSNLYVAElnrPVPVPI-SGYPPFMNQAQQQHIQVIYTGQPY 339
Cdd:PRK10263  330 TQSWAAPVEPVTQT-----PPVASVDVPPAQPTVAWQPVPGPQTGE---PVIAPApEGYPQQSQYAQPAVQYNEPLQQPV 401

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237304   340 iTGNSPMTLPATAYHHTNHVYYQRPPQPYPI-YYIPVEQYSSRHVQALPVKPSTVLNYHQVDSPVVRTSSPLAPEFSSQV 418
Cdd:PRK10263  402 -QPQQPYYAPAAEQPAQQPYYAPAPEQPAQQpYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQ 480

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15237304   419 yPLSKPVDSSVQTSSEATLNTTSRDAFIYNTDVDDDNDIAHAQIYKSQPPAP 470
Cdd:PRK10263  481 -PQPVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKRAREREQLAAWYQPIP 531
 
Name Accession Description Interval E-value
PB1_UP2 cd06410
Uncharacterized protein 2. The PB1 domain is a modular domain mediating specific ...
 34-136 1.19e-40

Uncharacterized protein 2. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in many critical cell processes such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions.


Pssm-ID: 99731  Cd Length: 97  Bit Score: 140.82  E-value: 1.19e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237304  34 MCRYGGSIVSPPQTKSPRYVGGDTRIVAIPSSaeTSFASLVSHLTVTLKISYPFKVKYQLPDQELDSLISVEADEDVQIM 113
Cdd:cd06410   1 LCSYGGRILPRPPDGQLRYVGGETRIVSVDRS--ISFKELVSKLSELFGAGVVVTLKYQLPDEDLDALISVSNDEDLKNM 78

                        90       100
                ....*....|....*....|...
gi 15237304 114 MEEHGYLSSESsipqSRIRLFLF 136
Cdd:cd06410  79 MEEYDRLSGGS----ARLRVFLF 97
PB1 pfam00564
PB1 domain;
45-138 1.11e-14

PB1 domain;


Pssm-ID: 395447  Cd Length: 84  Bit Score: 69.24  E-value: 1.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237304    45 PQTKSPRYVGGDTRIvaIPSSAETSFASLVSHLTVTLKISyPFKVKYQLPDQELDsLISVEADEDVQIMMEEHGylsses 124
Cdd:pfam00564   1 TVRLKLRYGGGIRRF--LSVSRGISFEELRALVEQRFGLD-DVDFKLKYPDEDGD-LVSLTSDEDLEEALEEAR------ 70

                          90
                  ....*....|....
gi 15237304   125 SIPQSRIRLFLFPL 138
Cdd:pfam00564  71 SLGSKSLRLHVFPT 84
PB1 smart00666
PB1 domain; Phox and Bem1p domain, present in many eukaryotic cytoplasmic signalling proteins. ...
 45-136 3.35e-12

PB1 domain; Phox and Bem1p domain, present in many eukaryotic cytoplasmic signalling proteins. The domain adopts a beta-grasp fold, similar to that found in ubiquitin and Ras-binding domains. A motif, variously termed OPR, PC and AID, represents the most conserved region of the majority of PB1 domains, and is necessary for PB1 domain function. This function is the formation of PB1 domain heterodimers, although not all PB1 domain pairs associate.


Pssm-ID: 214770  Cd Length: 81  Bit Score: 61.83  E-value: 3.35e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237304     45 PQTKSPRYvGGDTRIVAIPSSaeTSFASLVSHLTVTLKIS-YPFKVKYQlpDQELDsLISVEADEDVQIMMEEHGylsse 123
Cdd:smart00666   1 TVDVKLRY-GGETRRLSVPRD--ISFEDLRSKVAKRFGLDnQSFTLKYQ--DEDGD-LVSLTSDEDLEEAIEEYD----- 69

                           90
                   ....*....|...
gi 15237304    124 sSIPQSRIRLFLF 136
Cdd:smart00666  70 -SLGSKKLRLHVF 81
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 261-470 2.06e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.84  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237304   261 SQVKFAPIESVTSNdnsavTPIPSHELPSHSHAFENKPSSNLYVAElnrPVPVPI-SGYPPFMNQAQQQHIQVIYTGQPY 339
Cdd:PRK10263  330 TQSWAAPVEPVTQT-----PPVASVDVPPAQPTVAWQPVPGPQTGE---PVIAPApEGYPQQSQYAQPAVQYNEPLQQPV 401

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237304   340 iTGNSPMTLPATAYHHTNHVYYQRPPQPYPI-YYIPVEQYSSRHVQALPVKPSTVLNYHQVDSPVVRTSSPLAPEFSSQV 418
Cdd:PRK10263  402 -QPQQPYYAPAAEQPAQQPYYAPAPEQPAQQpYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQ 480

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15237304   419 yPLSKPVDSSVQTSSEATLNTTSRDAFIYNTDVDDDNDIAHAQIYKSQPPAP 470
Cdd:PRK10263  481 -PQPVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKRAREREQLAAWYQPIP 531
 
Name Accession Description Interval E-value
PB1_UP2 cd06410
Uncharacterized protein 2. The PB1 domain is a modular domain mediating specific ...
 34-136 1.19e-40

Uncharacterized protein 2. The PB1 domain is a modular domain mediating specific protein-protein interaction which play a role in many critical cell processes such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions.


Pssm-ID: 99731  Cd Length: 97  Bit Score: 140.82  E-value: 1.19e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237304  34 MCRYGGSIVSPPQTKSPRYVGGDTRIVAIPSSaeTSFASLVSHLTVTLKISYPFKVKYQLPDQELDSLISVEADEDVQIM 113
Cdd:cd06410   1 LCSYGGRILPRPPDGQLRYVGGETRIVSVDRS--ISFKELVSKLSELFGAGVVVTLKYQLPDEDLDALISVSNDEDLKNM 78

                        90       100
                ....*....|....*....|...
gi 15237304 114 MEEHGYLSSESsipqSRIRLFLF 136
Cdd:cd06410  79 MEEYDRLSGGS----ARLRVFLF 97
PB1 pfam00564
PB1 domain;
45-138 1.11e-14

PB1 domain;


Pssm-ID: 395447  Cd Length: 84  Bit Score: 69.24  E-value: 1.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237304    45 PQTKSPRYVGGDTRIvaIPSSAETSFASLVSHLTVTLKISyPFKVKYQLPDQELDsLISVEADEDVQIMMEEHGylsses 124
Cdd:pfam00564   1 TVRLKLRYGGGIRRF--LSVSRGISFEELRALVEQRFGLD-DVDFKLKYPDEDGD-LVSLTSDEDLEEALEEAR------ 70

                          90
                  ....*....|....
gi 15237304   125 SIPQSRIRLFLFPL 138
Cdd:pfam00564  71 SLGSKSLRLHVFPT 84
PB1 smart00666
PB1 domain; Phox and Bem1p domain, present in many eukaryotic cytoplasmic signalling proteins. ...
 45-136 3.35e-12

PB1 domain; Phox and Bem1p domain, present in many eukaryotic cytoplasmic signalling proteins. The domain adopts a beta-grasp fold, similar to that found in ubiquitin and Ras-binding domains. A motif, variously termed OPR, PC and AID, represents the most conserved region of the majority of PB1 domains, and is necessary for PB1 domain function. This function is the formation of PB1 domain heterodimers, although not all PB1 domain pairs associate.


Pssm-ID: 214770  Cd Length: 81  Bit Score: 61.83  E-value: 3.35e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237304     45 PQTKSPRYvGGDTRIVAIPSSaeTSFASLVSHLTVTLKIS-YPFKVKYQlpDQELDsLISVEADEDVQIMMEEHGylsse 123
Cdd:smart00666   1 TVDVKLRY-GGETRRLSVPRD--ISFEDLRSKVAKRFGLDnQSFTLKYQ--DEDGD-LVSLTSDEDLEEAIEEYD----- 69

                           90
                   ....*....|...
gi 15237304    124 sSIPQSRIRLFLF 136
Cdd:smart00666  70 -SLGSKKLRLHVF 81
PB1 cd05992
The PB1 domain is a modular domain mediating specific protein-protein interactions which play ...
 51-136 7.28e-12

The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domain, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as a noncanonical PB1-interactions. The PB1 domain module is conserved in amoebas, fungi, animals, and plants.


Pssm-ID: 99716 [Multi-domain]  Cd Length: 81  Bit Score: 61.14  E-value: 7.28e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237304  51 RYVGGDTRIVAIPSSaeTSFASLVSHLTVTLKISyPFKVKYQLPDQELDsLISVEADEDVQIMMEEHgylsseSSIPQSR 130
Cdd:cd05992   6 KYGGEIRRFVVVSRS--ISFEDLRSKIAEKFGLD-AVSFKLKYPDEDGD-LVTISSDEDLEEAIEEA------RRSGSKK 75


                ....*.
gi 15237304 131 IRLFLF 136
Cdd:cd05992  76 LRLFVF 81
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 261-470 2.06e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.84  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237304   261 SQVKFAPIESVTSNdnsavTPIPSHELPSHSHAFENKPSSNLYVAElnrPVPVPI-SGYPPFMNQAQQQHIQVIYTGQPY 339
Cdd:PRK10263  330 TQSWAAPVEPVTQT-----PPVASVDVPPAQPTVAWQPVPGPQTGE---PVIAPApEGYPQQSQYAQPAVQYNEPLQQPV 401

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237304   340 iTGNSPMTLPATAYHHTNHVYYQRPPQPYPI-YYIPVEQYSSRHVQALPVKPSTVLNYHQVDSPVVRTSSPLAPEFSSQV 418
Cdd:PRK10263  402 -QPQQPYYAPAAEQPAQQPYYAPAPEQPAQQpYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQ 480

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 15237304   419 yPLSKPVDSSVQTSSEATLNTTSRDAFIYNTDVDDDNDIAHAQIYKSQPPAP 470
Cdd:PRK10263  481 -PQPVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKRAREREQLAAWYQPIP 531
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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