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Conserved domains on  [gi|15242318|ref|NP_197054|]
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Ankyrin repeat family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-265 2.00e-21

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.87  E-value: 2.00e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   2 DQRSLEAAAKSGNIDLLYELIHEDPYVLDKTDHVPFVNTPLHVAAVNGKTEFAMEMMNLKPSFARKLNADGLTPLHLAVE 81
Cdd:COG0666  17 LLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAAR 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318  82 HGHfwlvLEVVK------VDpslVRIKGRHGMTPLLVAVSRKKIDLMsEFFLGCPESIVDANVNGENALHIAVNNYDqre 155
Cdd:COG0666  97 NGD----LEIVKllleagAD---VNARDKDGETPLHLAAYNGNLEIV-KLLLEAGADVNAQDNDGNTPLHLAAANGN--- 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318 156 gLSVLKVLMgwilrlcQKDAEwietrvINRRDKDGNTPLHLAAYEINRQAMKLLLESsKINVNIENKNGLTVFDIAVLHN 235
Cdd:COG0666 166 -LEIVKLLL-------EAGAD------VNARDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDLAAENG 230

                       250       260       270
                ....*....|....*....|....*....|
gi 15242318 236 NREIERMVKRHGGKRSVSLVKIKTTSDILA 265
Cdd:COG0666 231 NLEIVKLLLEAGADLNAKDKDGLTALLLAA 260
PGG super family cl16503
Domain of unknown function; The PGG domain is named for the highly conserved sequence motif ...
 287-383 4.23e-08

Domain of unknown function; The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.


The actual alignment was detected with superfamily member pfam13962:

Pssm-ID: 433609  Cd Length: 114  Bit Score: 51.40  E-value: 4.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   287 EERRNALLVVATLIVTATYQTVLQPPGGV-SDGGGQKSGTsgPKAGSVVMDEVYFIwlwlWNSAGFCF---AIEMMIRLL 362
Cdd:pfam13962   5 KEARNTLLLVATLIATVTFAAGFTPPGGYwQDDDGPHAGK--PILAKNPAFKAFVI----SNAIAFFAslvAVVLLLSIV 78

                          90       100
                  ....*....|....*....|..
gi 15242318   363 SLGQESMFWY-YPLFVPMVLAY 383
Cdd:pfam13962  79 SDFLRSLPRKlRIGLKLLWVAL 100
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-265 2.00e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.87  E-value: 2.00e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   2 DQRSLEAAAKSGNIDLLYELIHEDPYVLDKTDHVPFVNTPLHVAAVNGKTEFAMEMMNLKPSFARKLNADGLTPLHLAVE 81
Cdd:COG0666  17 LLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAAR 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318  82 HGHfwlvLEVVK------VDpslVRIKGRHGMTPLLVAVSRKKIDLMsEFFLGCPESIVDANVNGENALHIAVNNYDqre 155
Cdd:COG0666  97 NGD----LEIVKllleagAD---VNARDKDGETPLHLAAYNGNLEIV-KLLLEAGADVNAQDNDGNTPLHLAAANGN--- 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318 156 gLSVLKVLMgwilrlcQKDAEwietrvINRRDKDGNTPLHLAAYEINRQAMKLLLESsKINVNIENKNGLTVFDIAVLHN 235
Cdd:COG0666 166 -LEIVKLLL-------EAGAD------VNARDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDLAAENG 230

                       250       260       270
                ....*....|....*....|....*....|
gi 15242318 236 NREIERMVKRHGGKRSVSLVKIKTTSDILA 265
Cdd:COG0666 231 NLEIVKLLLEAGADLNAKDKDGLTALLLAA 260
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 73-248 2.51e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 71.62  E-value: 2.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   73 LTPLHLAVEHGH-FWLVLEVVKV---DPSLVRIKGRHGMTPLLVAVSRKKIDL-MSEFFLGCPESIVDANVNGENALHIA 147
Cdd:PHA03100  69 STPLHYLSNIKYnLTDVKEIVKLlleYGANVNAPDNNGITPLLYAISKKSNSYsIVEYLLDNGANVNIKNSDGENLLHLY 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318  148 V-NNYDQregLSVLKVLMGWILRLCQKDaewietRV---------INRRDKDGNTPLHLAAYEINRQAMKLLLESSkINV 217
Cdd:PHA03100 149 LeSNKID---LKILKLLIDKGVDINAKN------RVnyllsygvpINIKDVYGFTPLHYAVYNNNPEFVKYLLDLG-ANP 218

                        170       180       190
                 ....*....|....*....|....*....|.
gi 15242318  218 NIENKNGLTVFDIAVLHNNREIERMVKRHGG 248
Cdd:PHA03100 219 NLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
Ank_2 pfam12796
Ankyrin repeats (3 copies);
6-93 1.16e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 1.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318     6 LEAAAKSGNIDLLYELIHEDPyvlDKTDHVPFVNTPLHVAAVNGKTEFAMEmmnLKPSFARKLNADGLTPLHLAVEHGHF 85
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA---DANLQDKNGRTALHLAAKNGHLEIVKL---LLEHADVNLKDNGRTALHYAARSGHL 74


                  ....*...
gi 15242318    86 WLVLEVVK 93
Cdd:pfam12796  75 EIVKLLLE 82
PGG pfam13962
Domain of unknown function; The PGG domain is named for the highly conserved sequence motif ...
 287-383 4.23e-08

Domain of unknown function; The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.


Pssm-ID: 433609  Cd Length: 114  Bit Score: 51.40  E-value: 4.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   287 EERRNALLVVATLIVTATYQTVLQPPGGV-SDGGGQKSGTsgPKAGSVVMDEVYFIwlwlWNSAGFCF---AIEMMIRLL 362
Cdd:pfam13962   5 KEARNTLLLVATLIATVTFAAGFTPPGGYwQDDDGPHAGK--PILAKNPAFKAFVI----SNAIAFFAslvAVVLLLSIV 78

                          90       100
                  ....*....|....*....|..
gi 15242318   363 SLGQESMFWY-YPLFVPMVLAY 383
Cdd:pfam13962  79 SDFLRSLPRKlRIGLKLLWVAL 100
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 189-219 1.73e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 1.73e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 15242318    189 DGNTPLHLAAYEINRQAMKLLLEsSKINVNI 219
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLD-KGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 191-239 5.15e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.23  E-value: 5.15e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 15242318 191 NTPLHLAAYEINRQAMKLLLESSKINVNIENKNGLTVFDIAVLHNNREI 239
Cdd:cd22192  18 ESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEA 66
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-265 2.00e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.87  E-value: 2.00e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   2 DQRSLEAAAKSGNIDLLYELIHEDPYVLDKTDHVPFVNTPLHVAAVNGKTEFAMEMMNLKPSFARKLNADGLTPLHLAVE 81
Cdd:COG0666  17 LLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAAR 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318  82 HGHfwlvLEVVK------VDpslVRIKGRHGMTPLLVAVSRKKIDLMsEFFLGCPESIVDANVNGENALHIAVNNYDqre 155
Cdd:COG0666  97 NGD----LEIVKllleagAD---VNARDKDGETPLHLAAYNGNLEIV-KLLLEAGADVNAQDNDGNTPLHLAAANGN--- 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318 156 gLSVLKVLMgwilrlcQKDAEwietrvINRRDKDGNTPLHLAAYEINRQAMKLLLESsKINVNIENKNGLTVFDIAVLHN 235
Cdd:COG0666 166 -LEIVKLLL-------EAGAD------VNARDNDGETPLHLAAENGHLEIVKLLLEA-GADVNAKDNDGKTALDLAAENG 230

                       250       260       270
                ....*....|....*....|....*....|
gi 15242318 236 NREIERMVKRHGGKRSVSLVKIKTTSDILA 265
Cdd:COG0666 231 NLEIVKLLLEAGADLNAKDKDGLTALLLAA 260
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
6-260 7.21e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 89.63  E-value: 7.21e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   6 LEAAAKSGNIDLLYELIHEDPYVLDKTDHVpfvNTPLHVAAVNGKTEFAMEMMNLKPSFARKlNADGLTPLHLAVEHGHf 85
Cdd:COG0666  58 LLAAALAGDLLVALLLLAAGADINAKDDGG---NTLLHAAARNGDLEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGN- 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318  86 wlvLEVVK------VDPSlvrIKGRHGMTPLLVAVSRKKIDLMsEFFLGCPESIVDANVNGENALHIAV--NNYDqregl 157
Cdd:COG0666 133 ---LEIVKllleagADVN---AQDNDGNTPLHLAAANGNLEIV-KLLLEAGADVNARDNDGETPLHLAAenGHLE----- 200

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318 158 sVLKVLMgwilrlcQKDAEwietrvINRRDKDGNTPLHLAAYEINRQAMKLLLEsSKINVNIENKNGLTVFDIAVLHNNR 237
Cdd:COG0666 201 -IVKLLL-------EAGAD------VNAKDNDGKTALDLAAENGNLEIVKLLLE-AGADLNAKDKDGLTALLLAAAAGAA 265

                       250       260
                ....*....|....*....|...
gi 15242318 238 EIERMVKRHGGKRSVSLVKIKTT 260
Cdd:COG0666 266 LIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
39-267 3.35e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 81.92  E-value: 3.35e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318  39 NTPLHVAAVNGKTEFAMEMMNLKPSFARKLNADGLTPLHLAVEHGHFWLVLEVVKVDPSLVRIKGRHGMTPLLVAVSRKK 118
Cdd:COG0666  20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318 119 IDLMsEFFLGCPESIVDANVNGENALHIAVNNYDqregLSVLKVLMgwilrlcQKDAEwietrvINRRDKDGNTPLHLAA 198
Cdd:COG0666 100 LEIV-KLLLEAGADVNARDKDGETPLHLAAYNGN----LEIVKLLL-------EAGAD------VNAQDNDGNTPLHLAA 161

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15242318 199 YEINRQAMKLLLEsSKINVNIENKNGLTVFDIAVLHNNREIERMVKRHGGKRSVSLVKIKTTSDILASQ 267
Cdd:COG0666 162 ANGNLEIVKLLLE-AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAEN 229
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
54-239 2.14e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 70.37  E-value: 2.14e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318  54 AMEMMNLKPSFARKLNADGLTPLHLAVEHGHFWLVLEVVKVDPSLVRIKGRHGMTPLLVAVSRKKIDLMSEFFLGCPESI 133
Cdd:COG0666   1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318 134 VDANVNGENALHIAVNNYDqregLSVLKVLMgwilrlcQKDAEwietrvINRRDKDGNTPLHLAAYEINRQAMKLLLEsS 213
Cdd:COG0666  81 NAKDDGGNTLLHAAARNGD----LEIVKLLL-------EAGAD------VNARDKDGETPLHLAAYNGNLEIVKLLLE-A 142

                       170       180
                ....*....|....*....|....*.
gi 15242318 214 KINVNIENKNGLTVFDIAVLHNNREI 239
Cdd:COG0666 143 GADVNAQDNDGNTPLHLAAANGNLEI 168
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 73-248 2.51e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 71.62  E-value: 2.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   73 LTPLHLAVEHGH-FWLVLEVVKV---DPSLVRIKGRHGMTPLLVAVSRKKIDL-MSEFFLGCPESIVDANVNGENALHIA 147
Cdd:PHA03100  69 STPLHYLSNIKYnLTDVKEIVKLlleYGANVNAPDNNGITPLLYAISKKSNSYsIVEYLLDNGANVNIKNSDGENLLHLY 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318  148 V-NNYDQregLSVLKVLMGWILRLCQKDaewietRV---------INRRDKDGNTPLHLAAYEINRQAMKLLLESSkINV 217
Cdd:PHA03100 149 LeSNKID---LKILKLLIDKGVDINAKN------RVnyllsygvpINIKDVYGFTPLHYAVYNNNPEFVKYLLDLG-ANP 218

                        170       180       190
                 ....*....|....*....|....*....|.
gi 15242318  218 NIENKNGLTVFDIAVLHNNREIERMVKRHGG 248
Cdd:PHA03100 219 NLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
Ank_2 pfam12796
Ankyrin repeats (3 copies);
6-93 1.16e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 1.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318     6 LEAAAKSGNIDLLYELIHEDPyvlDKTDHVPFVNTPLHVAAVNGKTEFAMEmmnLKPSFARKLNADGLTPLHLAVEHGHF 85
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA---DANLQDKNGRTALHLAAKNGHLEIVKL---LLEHADVNLKDNGRTALHYAARSGHL 74


                  ....*...
gi 15242318    86 WLVLEVVK 93
Cdd:pfam12796  75 EIVKLLLE 82
PGG pfam13962
Domain of unknown function; The PGG domain is named for the highly conserved sequence motif ...
 287-383 4.23e-08

Domain of unknown function; The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.


Pssm-ID: 433609  Cd Length: 114  Bit Score: 51.40  E-value: 4.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   287 EERRNALLVVATLIVTATYQTVLQPPGGV-SDGGGQKSGTsgPKAGSVVMDEVYFIwlwlWNSAGFCF---AIEMMIRLL 362
Cdd:pfam13962   5 KEARNTLLLVATLIATVTFAAGFTPPGGYwQDDDGPHAGK--PILAKNPAFKAFVI----SNAIAFFAslvAVVLLLSIV 78

                          90       100
                  ....*....|....*....|..
gi 15242318   363 SLGQESMFWY-YPLFVPMVLAY 383
Cdd:pfam13962  79 SDFLRSLPRKlRIGLKLLWVAL 100
Ank_2 pfam12796
Ankyrin repeats (3 copies);
144-239 1.04e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.34  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   144 LHIAVNNYDqregLSVLKVLMgwilrlcQKDAEwietrvINRRDKDGNTPLHLAAYEINRQAMKLLLEssKINVNIENkN 223
Cdd:pfam12796   1 LHLAAKNGN----LELVKLLL-------ENGAD------ANLQDKNGRTALHLAAKNGHLEIVKLLLE--HADVNLKD-N 60

                          90
                  ....*....|....*.
gi 15242318   224 GLTVFDIAVLHNNREI 239
Cdd:pfam12796  61 GRTALHYAARSGHLEI 76
Ank_2 pfam12796
Ankyrin repeats (3 copies);
110-221 3.26e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.19  E-value: 3.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   110 LLVAVSRKKIDLMsEFFLGCPESIVDANVNGENALHIAVNNYDqregLSVLKVLmgwilrlcqkdaewIETRVINRRDkD 189
Cdd:pfam12796   1 LHLAAKNGNLELV-KLLLENGADANLQDKNGRTALHLAAKNGH----LEIVKLL--------------LEHADVNLKD-N 60

                          90       100       110
                  ....*....|....*....|....*....|..
gi 15242318   190 GNTPLHLAAYEINRQAMKLLLEsSKINVNIEN 221
Cdd:pfam12796  61 GRTALHYAARSGHLEIVKLLLE-KGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 40-243 1.57e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.41  E-value: 1.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   40 TPLHVAAVNGKTEfamEMMNLkpsFARKlNAD-------GLTPLHLAvehghfwlvLEVVKVDPSLVRI---KG------ 103
Cdd:PHA03095  85 TPLHLYLYNATTL---DVIKL---LIKA-GADvnakdkvGRTPLHVY---------LSGFNINPKVIRLllrKGadvnal 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318  104 -RHGMTPLLVAVSRKKIDL-MSEFFLGCPESIVDANVNGENALHIAVNNYDQREglSVLKVLmgwILRLCQKDAEWIETR 181
Cdd:PHA03095 149 dLYGMTPLAVLLKSRNANVeLLRLLIDAGADVYAVDDRFRSLLHHHLQSFKPRA--RIVREL---IRAGCDPAATDMLGN 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318  182 V-------------------------INRRDKDGNTPLHLAAYEINRQAMKLLLESSKiNVNIENKNGLTVFDIAVLHNN 236
Cdd:PHA03095 224 TplhsmatgssckrslvlplliagisINARNRYGQTPLHYAAVFNNPRACRRLIALGA-DINAVSSDGNTPLSLMVRNNN 302


                 ....*..
gi 15242318  237 REIERMV 243
Cdd:PHA03095 303 GRAVRAA 309
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 55-247 3.10e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.49  E-value: 3.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   55 MEMMNLKPSFARKLNADGLTPLHLAVEHGHFWLVLEVVKVDPSlVRIKGRHGMTPLLVAVSRKKIDLMSEFFlgcPESIV 134
Cdd:PHA02878  20 IEYIDHTENYSTSASLIPFIPLHQAVEARNLDVVKSLLTRGHN-VNQPDHRDLTPLHIICKEPNKLGMKEMI---RSINK 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318  135 DANVNGENALHIAVNNYDQREGLSVL-----KVLMGWILRLCQKDA-EWIETRV----------INRRDKD-GNTPLHLA 197
Cdd:PHA02878  96 CSVFYTLVAIKDAFNNRNVEIFKIILtnrykNIQTIDLVYIDKKSKdDIIEAEItklllsygadINMKDRHkGNTALHYA 175

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 15242318  198 AYEINRQAMKLLLeSSKINVNIENKNGLTVFDIAVLHNNREIERMVKRHG 247
Cdd:PHA02878 176 TENKDQRLTELLL-SYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENG 224
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 137-252 6.08e-06

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 46.02  E-value: 6.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318  137 NVNGENALHIaVNNYDQREGLSVLKVLMGWilrlcqkDAEwietrvINRRD-KDGNTPLHLAAYEINRQAMKLLLESSKI 215
Cdd:PHA02736  52 NRHGKQCVHI-VSNPDKADPQEKLKLLMEW-------GAD------INGKErVFGNTPLHIAVYTQNYELATWLCNQPGV 117

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 15242318  216 NVNIENKNGLTVFDIAVLHNNREIERMVKRHGGKRSV 252
Cdd:PHA02736 118 NMEILNYAFKTPYYVACERHDAKMMNILRAKGAQCKV 154
Ank_5 pfam13857
Ankyrin repeats (many copies);
183-231 3.30e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 3.30e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 15242318   183 INRRDKDGNTPLHLAAYEINRQAMKLLLEsSKINVNIENKNGLTVFDIA 231
Cdd:pfam13857   9 LNRLDGEGYTPLHVAAKYGALEIVRVLLA-YGVDLNLKDEEGLTALDLA 56
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 99-243 3.33e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.11  E-value: 3.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   99 VRIKGRHGMTPLLVAVSRKKIDLMSEFFlgcpESIVDANV---NGENALHIAV--NNYDqreglsVLKVLMgwilrlcQK 173
Cdd:PHA02874 117 VNIKDAELKTFLHYAIKKGDLESIKMLF----EYGADVNIeddNGCYPIHIAIkhNFFD------IIKLLL-------EK 179

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318  174 DAewietrVINRRDKDGNTPLHLAAYEINRQAMKLLLESSKiNVNIENKNGLTVFDIAVLHNNREIERMV 243
Cdd:PHA02874 180 GA------YANVKDNNGESPLHNAAEYGDYACIKLLIDHGN-HIMNKCKNGFTPLHNAIIHNRSAIELLI 242
Ank_4 pfam13637
Ankyrin repeats (many copies);
190-239 8.92e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 8.92e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 15242318   190 GNTPLHLAAYEINRQAMKLLLESsKINVNIENKNGLTVFDIAVLHNNREI 239
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEV 49
Ank_4 pfam13637
Ankyrin repeats (many copies);
39-88 1.46e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 1.46e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15242318    39 NTPLHVAAVNGKTEFAMEMMNLKPSFARkLNADGLTPLHLAVEHGHF----WLV 88
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINA-VDGNGETALHFAASNGNVevlkLLL 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 189-222 1.53e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 1.53e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15242318   189 DGNTPLHLAAYEINRQAM-KLLLESSkINVNIENK 222
Cdd:pfam00023   1 DGNTPLHLAAGRRGNLEIvKLLLSKG-ADVNARDK 34
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 74-247 1.55e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.83  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   74 TPLHLAVEHGHFWLVLEVVKVDPSLVRIKGRHGMTPLLVAVSRKKIDLMSEFFLGCPESIVdANVNGENALHIAVNNYDq 153
Cdd:PHA02875  70 SELHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDI-PNTDKFSPLHLAVMMGD- 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318  154 regLSVLKVLMGWilRLCqkdaewietrvINRRDKDGNTPLHLAAYEINRQAMKLLLESSKiNVNIENKNG-LTVFDIAV 232
Cdd:PHA02875 148 ---IKGIELLIDH--KAC-----------LDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA-NIDYFGKNGcVAALCYAI 210

                        170
                 ....*....|....*
gi 15242318  233 LHNNREIERMVKRHG 247
Cdd:PHA02875 211 ENNKIDIVRLFIKRG 225
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 40-237 2.34e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.41  E-value: 2.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   40 TPLHVAAVNGKtefaMEMMNLKPSFARKLNA---DGLTPLHLAVEHgHFWLVLEVVKVDPSLVRIKGRHGMTPLLVAVSR 116
Cdd:PHA02874 126 TFLHYAIKKGD----LESIKMLFEYGADVNIeddNGCYPIHIAIKH-NFFDIIKLLLEKGAYANVKDNNGESPLHNAAEY 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318  117 KKIDLMsEFFLGCPESIVDANVNGENALHIAVNnYDQreglSVLKVLmgwilrlcqkdaewIETRVINRRDKDGNTPLHL 196
Cdd:PHA02874 201 GDYACI-KLLIDHGNHIMNKCKNGFTPLHNAII-HNR----SAIELL--------------INNASINDQDIDGSTPLHH 260

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 15242318  197 A-AYEINRQAMKLLLeSSKINVNIENKNGLTVFDIAVLHNNR 237
Cdd:PHA02874 261 AiNPPCDIDIIDILL-YHKADISIKDNKGENPIDTAFKYINK 301
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 184-246 2.59e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.35  E-value: 2.59e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15242318  184 NRRDKDGNTPLHLAAYEINRQAMKLLLESSKiNVNIENKNGLTVFDIAVLHNNREIERMVKRH 246
Cdd:PTZ00322 109 NCRDYDGRTPLHIACANGHVQVVRVLLEFGA-DPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 99-244 4.63e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 42.56  E-value: 4.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   99 VRIKGRH-GMTPLLVAVSRKKIDLMsEFFLgcpesIVDANVNGEN-----ALHIAVNNYDQReglsVLKVLMgwilrlcQ 172
Cdd:PHA02878 160 INMKDRHkGNTALHYATENKDQRLT-ELLL-----SYGANVNIPDktnnsPLHHAVKHYNKP----IVHILL-------E 222

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15242318  173 KDAEwietrvINRRDKDGNTPLHLA-AYEINRQAMKLLLESSkINVNIENknglTVFDIAVLHNNREIERMVK 244
Cdd:PHA02878 223 NGAS------TDARDKCGNTPLHISvGYCKDYDILKLLLEHG-VDVNAKS----YILGLTALHSSIKSERKLK 284
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 189-219 1.73e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 1.73e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 15242318    189 DGNTPLHLAAYEINRQAMKLLLEsSKINVNI 219
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLD-KGADINA 30
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 39-121 2.58e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.97  E-value: 2.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318   39 NTPLHVAAVNGKtefaMEMMNLKpsFARKL-----NADGLTPLHLAVEHGHFWLVLEVVKVDPSLvRIKGRHGMTPLLVA 113
Cdd:PHA02875 103 MTPLHLATILKK----LDIMKLL--IARGAdpdipNTDKFSPLHLAVMMGDIKGIELLIDHKACL-DIEDCCGCTPLIIA 175


                 ....*...
gi 15242318  114 VSRKKIDL 121
Cdd:PHA02875 176 MAKGDIAI 183
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 183-261 4.60e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.48  E-value: 4.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15242318  183 INRRDKDGNTPLHLAAYEINRQAMKLLLeSSKINVNIENKngLTVFDIAVLHNNREIERMV--KRHGGKRSVSLVKIKTT 260
Cdd:PHA02878  63 VNQPDHRDLTPLHIICKEPNKLGMKEMI-RSINKCSVFYT--LVAIKDAFNNRNVEIFKIIltNRYKNIQTIDLVYIDKK 139


                 .
gi 15242318  261 S 261
Cdd:PHA02878 140 S 140
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 191-239 5.15e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 39.23  E-value: 5.15e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 15242318 191 NTPLHLAAYEINRQAMKLLLESSKINVNIENKNGLTVFDIAVLHNNREI 239
Cdd:cd22192  18 ESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEA 66
Ank_4 pfam13637
Ankyrin repeats (many copies);
177-210 9.05e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.56  E-value: 9.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 15242318   177 WIETRV-INRRDKDGNTPLHLAAYEINRQAMKLLL 210
Cdd:pfam13637  20 LLEKGAdINAVDGNGETALHFAASNGNVEVLKLLL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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