|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00123 |
PLN00123 |
isocitrate dehydrogenase (NAD+) |
8-368 |
0e+00 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215065 Cd Length: 360 Bit Score: 723.96 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 8 IFNRLLAnPPSPFTSLSRSITYMPRPGDGAPRTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEVLGNMRKVPEEVI 87
Cdd:PLN00123 1 LLKRLLS-NALGSKAQRRSVTYMPRPGDGAPRAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEVHGDMKKVPEEVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 88 ESVKRNKVCLKGGLATPVGGGVSSLNMQLRKELDIFASLVNCINVPGLVTRHENVDIVVIRENTEGEYSGLEHEVVPGVV 167
Cdd:PLN00123 80 ESIRRNKVCLKGGLATPVGGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 168 ESLKVITKFCSERIARYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQ 247
Cdd:PLN00123 160 ESLKVITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 248 FDVMVTPNLYGNLIANTAAGIAGGTGVMPGGNVGAEHAIFEQGASAGNVGNDKMVEQKKANPVALLLSSAMMLRHLRFPT 327
Cdd:PLN00123 240 FDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGASAGNVGNEKLVEQKKANPVALLLSSAMMLRHLQFPS 319
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 15237075 328 FADRLETAVKQVIKEGKYRTKDLGGDCTTQEVVDAVIAALE 368
Cdd:PLN00123 320 FADRLETAVKRVIAEGKYRTKDLGGSSTTQEVVDAVIANLD 360
|
|
| mito_nad_idh |
TIGR00175 |
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ... |
36-367 |
0e+00 |
|
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]
Pssm-ID: 272942 Cd Length: 333 Bit Score: 537.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 36 GAPRTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEVLG---NMRKVPEEVIESVKRNKVCLKGGLATPVG-GGVSS 111
Cdd:TIGR00175 1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPqtdGKTEIPDEAVESIKRNKVALKGPLETPIGkGGHRS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 112 LNMQLRKELDIFASLVNCINVPGLVTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIARYAFEYAYL 191
Cdd:TIGR00175 81 LNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYARK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 192 NNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLIANTAAGIAGG 271
Cdd:TIGR00175 161 NGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVGG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 272 TGVMPGGNVGAEHAIFEQGASAGNVgndKMVEQKKANPVALLLSSAMMLRHLRFPTFADRLETAVKQVIKEGKYRTKDLG 351
Cdd:TIGR00175 241 PGLVPGANIGRDYAVFEPGVRHTGP---DIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLG 317
|
330
....*....|....*.
gi 15237075 352 GDCTTQEVVDAVIAAL 367
Cdd:TIGR00175 318 GTATTSDFTEAVIKRL 333
|
|
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
39-367 |
3.14e-131 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 378.97 E-value: 3.14e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 39 RTVTLIPGDGIGPLVTGAVEQVMEAM-----------HAPVHFERYEVLGNMrkVPEEVIESVKRNKVCLKGGLATPV-- 105
Cdd:COG0473 2 YKIAVLPGDGIGPEVVAAALKVLEAAaerfgldfefeEADIGGAAYDKTGTP--LPDETLEALRKADAILLGAVGGPKwd 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 106 -GGGVSSLNMQLRKELDIFASLVNCINVPGLVTRH-----ENVDIVVIRENTEGEYSGLEHEVVPG----VVESLKVITK 175
Cdd:COG0473 80 dGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRVYTR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 176 FCSERIARYAFEYAyLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVTPN 255
Cdd:COG0473 160 KGIERIARYAFELA-RKRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTEN 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 256 LYGNLIANTAAGIAGGTGVMPGGNVGAEH-AIFE-QGASA----GnvgndkmveQKKANPVALLLSSAMMLRHLRFPTFA 329
Cdd:COG0473 239 LFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEpVHGSApdiaG---------KGIANPIATILSAAMMLRHLGEEEAA 309
|
330 340 350
....*....|....*....|....*....|....*...
gi 15237075 330 DRLETAVKQVIKEGkYRTKDLGGDCTTQEVVDAVIAAL 367
Cdd:COG0473 310 DAIEAAVEKVLAEG-VRTPDLGGKAGTSEMGDAIIAAL 346
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
40-363 |
1.97e-101 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 303.45 E-value: 1.97e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 40 TVTLIPGDGIGPLVTGAVEQVMEAM-HAPVH---FERYEVLGNMR-----KVPEEVIESVKRNKVCLKGGLATPVG--GG 108
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAAlEKAPLefeFEERDVGGAAIdetgePLPDETLEACKKADAVLLGAVGGPKWdpAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 109 VSSLN--MQLRKELDIFASLVNCINVPGLVT------RHENVDIVVIRENTEGEYSGLEHEVVPG---VVESLKVITKFC 177
Cdd:pfam00180 81 VRPENglLALRKELGLFANLRPAKVFPPLGDasplknEVEGVDIVIVRELTGGIYFGIEKGIKGSgneVAVDTKLYSRDE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 178 SERIARYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVTPNLY 257
Cdd:pfam00180 161 IERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 258 GNLIANTAAGIAGGTGVMPGGNVGA-EHAIFEQ-GASAGNVGNdkmveQKKANPVALLLSSAMMLRH-LRFPTFADRLET 334
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGAnGFGIFEPvHGSAPDIAG-----KGIANPIATILSAAMMLRYsLGLEDAADKIEA 315
|
330 340 350
....*....|....*....|....*....|..
gi 15237075 335 AVKQVIKEGkYRTKDLGGDCT---TQEVVDAV 363
Cdd:pfam00180 316 AVLKVLESG-IRTGDLAGSATyvsTSEFGEAV 346
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00123 |
PLN00123 |
isocitrate dehydrogenase (NAD+) |
8-368 |
0e+00 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215065 Cd Length: 360 Bit Score: 723.96 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 8 IFNRLLAnPPSPFTSLSRSITYMPRPGDGAPRTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEVLGNMRKVPEEVI 87
Cdd:PLN00123 1 LLKRLLS-NALGSKAQRRSVTYMPRPGDGAPRAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEVHGDMKKVPEEVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 88 ESVKRNKVCLKGGLATPVGGGVSSLNMQLRKELDIFASLVNCINVPGLVTRHENVDIVVIRENTEGEYSGLEHEVVPGVV 167
Cdd:PLN00123 80 ESIRRNKVCLKGGLATPVGGGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 168 ESLKVITKFCSERIARYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQ 247
Cdd:PLN00123 160 ESLKVITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 248 FDVMVTPNLYGNLIANTAAGIAGGTGVMPGGNVGAEHAIFEQGASAGNVGNDKMVEQKKANPVALLLSSAMMLRHLRFPT 327
Cdd:PLN00123 240 FDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGASAGNVGNEKLVEQKKANPVALLLSSAMMLRHLQFPS 319
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 15237075 328 FADRLETAVKQVIKEGKYRTKDLGGDCTTQEVVDAVIAALE 368
Cdd:PLN00123 320 FADRLETAVKRVIAEGKYRTKDLGGSSTTQEVVDAVIANLD 360
|
|
| mito_nad_idh |
TIGR00175 |
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ... |
36-367 |
0e+00 |
|
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]
Pssm-ID: 272942 Cd Length: 333 Bit Score: 537.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 36 GAPRTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEVLG---NMRKVPEEVIESVKRNKVCLKGGLATPVG-GGVSS 111
Cdd:TIGR00175 1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPqtdGKTEIPDEAVESIKRNKVALKGPLETPIGkGGHRS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 112 LNMQLRKELDIFASLVNCINVPGLVTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIARYAFEYAYL 191
Cdd:TIGR00175 81 LNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYARK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 192 NNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLIANTAAGIAGG 271
Cdd:TIGR00175 161 NGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVGG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 272 TGVMPGGNVGAEHAIFEQGASAGNVgndKMVEQKKANPVALLLSSAMMLRHLRFPTFADRLETAVKQVIKEGKYRTKDLG 351
Cdd:TIGR00175 241 PGLVPGANIGRDYAVFEPGVRHTGP---DIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLG 317
|
330
....*....|....*.
gi 15237075 352 GDCTTQEVVDAVIAAL 367
Cdd:TIGR00175 318 GTATTSDFTEAVIKRL 333
|
|
| PLN00118 |
PLN00118 |
isocitrate dehydrogenase (NAD+) |
14-367 |
2.71e-131 |
|
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215062 Cd Length: 372 Bit Score: 380.38 E-value: 2.71e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 14 ANPPSPFTSLSRSITYmprpgDGAPRTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEV-------LGNMrkVPEEV 86
Cdd:PLN00118 22 SSSSGAFSSSARAFSS-----SSTPITATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVgttvdprTGSF--LTWES 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 87 IESVKRNKVCLKGGLATPVGGGVSSLNMQLRKELDIFASLVNCINVPGLVTRHENVDIVVIRENTEGEYSGLEHEVVPGV 166
Cdd:PLN00118 95 LESVRRNKVGLKGPMATPIGKGHRSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTEGEYSGLEHQVVRGV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 167 VESLKVITKFCSERIARYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPE 246
Cdd:PLN00118 175 VESLKIITRQASLRVAEYAFHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 247 QFDVMVTPNLYGNLIANTAAGIAGGTGVMPGGNVGaEHAIFEQGASAGNVGNdkMVEQKKANPVALLLSSAMMLRHLRFP 326
Cdd:PLN00118 255 LFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIG-ENGLALAEAVHGSAPD--IAGKNLANPTALLLSAVMMLRHLKLN 331
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 15237075 327 TFADRLETAVKQVIKEGKYRTKDLGGDCTTQEVVDAVIAAL 367
Cdd:PLN00118 332 EQAEQIHNAILNTIAEGKYRTADLGGSSTTTDFTKAICDHL 372
|
|
| LeuB |
COG0473 |
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ... |
39-367 |
3.14e-131 |
|
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440241 Cd Length: 346 Bit Score: 378.97 E-value: 3.14e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 39 RTVTLIPGDGIGPLVTGAVEQVMEAM-----------HAPVHFERYEVLGNMrkVPEEVIESVKRNKVCLKGGLATPV-- 105
Cdd:COG0473 2 YKIAVLPGDGIGPEVVAAALKVLEAAaerfgldfefeEADIGGAAYDKTGTP--LPDETLEALRKADAILLGAVGGPKwd 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 106 -GGGVSSLNMQLRKELDIFASLVNCINVPGLVTRH-----ENVDIVVIRENTEGEYSGLEHEVVPG----VVESLKVITK 175
Cdd:COG0473 80 dGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRVYTR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 176 FCSERIARYAFEYAyLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVTPN 255
Cdd:COG0473 160 KGIERIARYAFELA-RKRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTEN 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 256 LYGNLIANTAAGIAGGTGVMPGGNVGAEH-AIFE-QGASA----GnvgndkmveQKKANPVALLLSSAMMLRHLRFPTFA 329
Cdd:COG0473 239 LFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEpVHGSApdiaG---------KGIANPIATILSAAMMLRHLGEEEAA 309
|
330 340 350
....*....|....*....|....*....|....*...
gi 15237075 330 DRLETAVKQVIKEGkYRTKDLGGDCTTQEVVDAVIAAL 367
Cdd:COG0473 310 DAIEAAVEKVLAEG-VRTPDLGGKAGTSEMGDAIIAAL 346
|
|
| PRK08997 |
PRK08997 |
isocitrate dehydrogenase; Provisional |
39-367 |
3.16e-113 |
|
isocitrate dehydrogenase; Provisional
Pssm-ID: 181606 Cd Length: 334 Bit Score: 332.84 E-value: 3.16e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 39 RTVTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEV-LGNMRK----VPEEVIESVKRNKVCLKGGLATPVGGGVSSLN 113
Cdd:PRK08997 3 QTITVIPGDGIGPSIIDATLKILDKLGCDFEYEFADAgLTALEKhgelLPQRTLDLIEKNKIALKGPLTTPVGEGFTSIN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 114 MQLRKELDIFASLVNCINVPGLVTRHENVDIVVIRENTEGEYSGLEHEVVP--GVVESLKVITKFCSERIARYAFEYAYL 191
Cdd:PRK08997 83 VTLRKKFDLYANVRPVLSFPGTKARYDNIDIITVRENTEGMYSGEGQTVSEdgETAEATSIITRKGAERIVRFAYELARK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 192 NNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLIANTAAGIAGG 271
Cdd:PRK08997 163 EGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGLVGG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 272 TGVMPGGNVGAEHAIFEQ-GASAGNVGNdkmveQKKANPVALLLSSAMMLRHLRFPTFADRLETAVKQVIKEGKYRTKDL 350
Cdd:PRK08997 243 LGMAPGANIGRDAAIFEAvHGSAPDIAG-----KNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRTTRDL 317
|
330
....*....|....*..
gi 15237075 351 GGDCTTQEVVDAVIAAL 367
Cdd:PRK08997 318 GGTHGTTDFTQAVIDRL 334
|
|
| PRK09222 |
PRK09222 |
NADP-dependent isocitrate dehydrogenase; |
41-367 |
1.78e-102 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236416 [Multi-domain] Cd Length: 482 Bit Score: 310.67 E-value: 1.78e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 41 VTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEV------LGNMRKVPEEVIESVKRNKVCLKGGLATPVGGGVSSLNM 114
Cdd:PRK09222 7 ITVAYGDGIGPEIMEAVLKILEAAGAPLEIETIEIgekvykKGWTSGISPSAWESIRRTKVLLKAPITTPQGGGYKSLNV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 115 QLRKELDIFASLVNCINV-PGLVTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIARYAFEYAYLNN 193
Cdd:PRK09222 87 TLRKTLGLYANVRPCVSYhPFVETKHPNLDVVIIRENEEDLYAGIEHRQTPDVYQCLKLISRPGSEKIIRYAFEYARANG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 194 RKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLIANTAAGIAGGTG 273
Cdd:PRK09222 167 RKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 274 VMPGGNVGAEHAIFE--QGAS---AGnvgndkmveQKKANPVALLLSSAMMLRHLRFPTFADRLETAVKQVIKEGKYrTK 348
Cdd:PRK09222 247 LAGSANIGEEYAMFEavHGSApdiAG---------KNIANPSGLLNAAVMMLVHIGQFDIAELIENAWLKTLEDGIH-TA 316
|
330 340
....*....|....*....|....*
gi 15237075 349 DLGGDCT------TQEVVDAVIAAL 367
Cdd:PRK09222 317 DIYNEGVskkkvgTKEFAEAVIENL 341
|
|
| Iso_dh |
pfam00180 |
Isocitrate/isopropylmalate dehydrogenase; |
40-363 |
1.97e-101 |
|
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507 Cd Length: 346 Bit Score: 303.45 E-value: 1.97e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 40 TVTLIPGDGIGPLVTGAVEQVMEAM-HAPVH---FERYEVLGNMR-----KVPEEVIESVKRNKVCLKGGLATPVG--GG 108
Cdd:pfam00180 1 KIAVLPGDGIGPEVMAAALKVLKAAlEKAPLefeFEERDVGGAAIdetgePLPDETLEACKKADAVLLGAVGGPKWdpAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 109 VSSLN--MQLRKELDIFASLVNCINVPGLVT------RHENVDIVVIRENTEGEYSGLEHEVVPG---VVESLKVITKFC 177
Cdd:pfam00180 81 VRPENglLALRKELGLFANLRPAKVFPPLGDasplknEVEGVDIVIVRELTGGIYFGIEKGIKGSgneVAVDTKLYSRDE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 178 SERIARYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVTPNLY 257
Cdd:pfam00180 161 IERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 258 GNLIANTAAGIAGGTGVMPGGNVGA-EHAIFEQ-GASAGNVGNdkmveQKKANPVALLLSSAMMLRH-LRFPTFADRLET 334
Cdd:pfam00180 241 GDILSDEASMLTGSLGLLPSASLGAnGFGIFEPvHGSAPDIAG-----KGIANPIATILSAAMMLRYsLGLEDAADKIEA 315
|
330 340 350
....*....|....*....|....*....|..
gi 15237075 335 AVKQVIKEGkYRTKDLGGDCT---TQEVVDAV 363
Cdd:pfam00180 316 AVLKVLESG-IRTGDLAGSATyvsTSEFGEAV 346
|
|
| LEU3_arch |
TIGR02088 |
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ... |
41-364 |
8.34e-88 |
|
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.
Pssm-ID: 273962 Cd Length: 322 Bit Score: 267.78 E-value: 8.34e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 41 VTLIPGDGIGPLVTGAVEQVMEAMHAPVHF-------ERYEVLGNmrKVPEEVIESVKRNKVCLKGGLATPVGGGVSSLN 113
Cdd:TIGR02088 1 VAVIPGDGIGPEVIEAAIRILNKLGLEIEFiefeagdEALKKYGS--ALPEDTLEEIRKADAILFGAVTTPANPGYKSVI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 114 MQLRKELDIFASLVNCINVPGLVTRH-ENVDIVVIRENTEGEYSGLEhEVVPGVVESLKVITKFCSERIARYAFEYAYLN 192
Cdd:TIGR02088 79 VTLRKELDLYANVRPAKSLPGIPDLYpNGKDIVIVRENTEGLYAGFE-FGFSDRAIAIRVITREGSERIARFAFNLAKER 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 193 NRKkVTAVHKANIMKLADGLFLESCREVAKHYsGITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLIANTAAGIAGGT 272
Cdd:TIGR02088 158 NRK-VTCVHKANVLKGTDGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRFDVIVTTNMFGDILSDLASALAGSL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 273 GVMPGGNVGAEHAIFE--QGASAGNVGndkmveQKKANPVALLLSSAMMLRHLRFPTFADRLETAVKQVIKEGkYRTKDL 350
Cdd:TIGR02088 236 GLAPSANIGDRKALFEpvHGSAPDIAG------KGIANPTAAILSVAMMLDYLGELEKGKLVWEAVEYYIIEG-KKTPDL 308
|
330
....*....|....
gi 15237075 351 GGDCTTQEVVDAVI 364
Cdd:TIGR02088 309 GGTAKTKEVGDEIA 322
|
|
| PRK14025 |
PRK14025 |
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional |
41-367 |
9.20e-86 |
|
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
Pssm-ID: 184462 Cd Length: 330 Bit Score: 262.76 E-value: 9.20e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 41 VTLIPGDGIGPLVTGAVEQVMEAMHAPVHF-------ERYEVLGnmRKVPEEVIESVKRNKVCLKGGlatpVGGGVSSLN 113
Cdd:PRK14025 4 ICVIEGDGIGKEVVPAALHVLEATGLPFEFvyaeagdEVFEKTG--KALPEETIEAAKEADAVLFGA----AGETAADVI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 114 MQLRKELDIFASLVNCINVPGLVTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIARYAFEYA---- 189
Cdd:PRK14025 78 VKLRRILDTYANVRPVKSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKASERIFRFAFEMAkrrk 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 190 YLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLIANTAAGIA 269
Cdd:PRK14025 158 KMGKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGLV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 270 GGTGVMPGGNVGAEHAIFEQ-GASAGNVGNDKMveqkkANPVALLLSSAMMLRHLRFPTFADRLETAVKQVIKEGKyRTK 348
Cdd:PRK14025 238 GGLGLAPSANIGDKYGLFEPvHGSAPDIAGKGI-----ANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGL-TTP 311
|
330
....*....|....*....
gi 15237075 349 DLGGDCTTQEVVDAVIAAL 367
Cdd:PRK14025 312 DLGGNLSTMEMAEEVAKRV 330
|
|
| ICDH_alpha |
TIGR02924 |
isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of ... |
41-367 |
3.01e-79 |
|
isocitrate dehydrogenase; This family of mainly alphaproteobacterial enzymes is a member of the isocitrate/isopropylmalate dehydrogenase superfamily described by pfam00180. Every member of the seed of this model appears to have a TCA cycle lacking only a determined isocitrate dehydrogenase. The precise identity of the cofactor (NADH -- 1.1.1.41 vs. NADPH -- 1.1.1.42) is unclear. [Energy metabolism, TCA cycle]
Pssm-ID: 274353 [Multi-domain] Cd Length: 473 Bit Score: 250.83 E-value: 3.01e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 41 VTLIPGDGIGPLVTGAVEQVMEAMHAPVHFERYEVLGNMRK------VPEEVIESVKRNKVCLKGGLATPVGGGVSSLNM 114
Cdd:TIGR02924 3 ITVAYGDGIGPEIMEAVLLILKEAEAPIDIETIEIGEKVYKkgwpsgISPSSWESIRRTKVLLKAPITTPQGGGHKSLNV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 115 QLRKELDIFASLVNCINV-PGLVTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIARYAFEYAYLNN 193
Cdd:TIGR02924 83 TLRKTLGLYANIRPCVSYhPFIETKSPNLNIVIVRENEEDLYTGIEYRQTPDTYECTKLITRSGSEKICRYAFEYARKHN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 194 RKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLIANTAAGIAGGTG 273
Cdd:TIGR02924 163 RKKVTCLTKDNIMKMTDGIFHKIFDKIAAEYPDIESEHYIVDIGMARLATNPENFDVIVTPNLYGDILSDVAAEISGSVG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 274 VMPGGNVGAEHAIFEQ-GASAGNVGNdkmveQKKANPVALLLSSAMMLRHLRFPTFADRLETAVKQVIKEGK-----YRT 347
Cdd:TIGR02924 243 LAGSANIGEEYAMFEAvHGSAPDIAG-----QNIANPSGLLNAAIQMLVHIGQSDIAQLIYNAWLKTLEDGVhtadiYNE 317
|
330 340
....*....|....*....|
gi 15237075 348 KDLGGDCTTQEVVDAVIAAL 367
Cdd:TIGR02924 318 KTSKQKVGTKEFAEAVTANL 337
|
|
| PRK00772 |
PRK00772 |
3-isopropylmalate dehydrogenase; Provisional |
41-368 |
9.34e-70 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 234832 Cd Length: 358 Bit Score: 222.67 E-value: 9.34e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 41 VTLIPGDGIGPLVTGAVEQVMEAM-----------HAPVHFERYEVLGNMrkVPEEVIE-------------------SV 90
Cdd:PRK00772 5 IAVLPGDGIGPEVMAEAVKVLDAVaekfgfdfefeEALVGGAAIDAHGVP--LPEETLEacraadavllgavggpkwdNL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 91 KRNKVCLKGGLAtpvgggvsslnmqLRKELDIFASLVNCINVPGLVT-------RHENVDIVVIRENTEGEYSGlEHEVV 163
Cdd:PRK00772 83 PPDVRPERGLLA-------------LRKELGLFANLRPAKLYPGLADasplkpeIVAGLDILIVRELTGGIYFG-EPRGR 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 164 PGVVESLK-----VITKFCSERIARYAFEYAyLNNRKKVTAVHKANIMKlADGLFLESCREVAKHYSGITYNEIIVDNCC 238
Cdd:PRK00772 149 EGLGGEERafdtmVYTREEIERIARVAFELA-RKRRKKVTSVDKANVLE-SSRLWREVVTEVAKEYPDVELSHMYVDNAA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 239 MQLVAKPEQFDVMVTPNLYGNLIANTAAGIAGGTGVMPGGNVGAE-HAIFEQ-GAS----AGnvgndkmveQKKANPVAL 312
Cdd:PRK00772 227 MQLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESgPGLYEPiHGSapdiAG---------KGIANPIAT 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 313 LLSSAMMLRH-LRFPTFADRLETAVKQVIKEGkYRTKDL---GGDCTTQEVVDAVIAALE 368
Cdd:PRK00772 298 ILSAAMMLRYsLGLEEAADAIEAAVEKVLAQG-YRTADIaegGGKVSTSEMGDAILAALA 356
|
|
| Icd |
COG0538 |
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ... |
44-368 |
4.42e-64 |
|
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304 Cd Length: 409 Bit Score: 209.58 E-value: 4.42e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 44 IPGDGIGPLVTGAVEQVM-EAMHAPVHFER-------------YEVLGNmrKVPEEVIESVKRNKVCLKGGLATPVGGGV 109
Cdd:COG0538 24 IEGDGIGPEITRAIWKVIdAAVEKAYGGKRdiewkevdagekaRDETGD--WLPDETAEAIKEYGVGIKGPLTTPVGGGW 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 110 SSLNMQLRKELDIFASL--VNCI-NVPGLVTRHENVDIVVIRENTEGEYSGLEHEV-VPGVVE----------------- 168
Cdd:COG0538 102 RSLNVTIRQILDLYVCRrpVRYFkGVPSPVKHPEKVDIVIFRENTEDIYAGIEWKAgSPEALKliffledemgvtvirfp 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 169 -----SLKVITKFCSERIARYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHY------------------- 224
Cdd:COG0538 182 edsgiGIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVAEEEfgdkfitegpwekykgpkp 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 225 -SGITYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLIANTAAGIAGGTGVMPGGNVGAE-HAIFEqgASAGNVgnDKMV 302
Cdd:COG0538 262 aGKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDgGAEFE--ATHGTA--PKYA 337
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15237075 303 EQKKANPVALLLSSAMMLRHLRFPTFADRLETAVKQVIKEGKYrTKDLG---GDCT---TQEVVDAVIAALE 368
Cdd:COG0538 338 GKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKV-TYDLArlmEGATelsTSEFGDAIIENLD 408
|
|
| PRK03437 |
PRK03437 |
3-isopropylmalate dehydrogenase; Provisional |
38-367 |
1.97e-59 |
|
3-isopropylmalate dehydrogenase; Provisional
Pssm-ID: 179579 Cd Length: 344 Bit Score: 195.53 E-value: 1.97e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 38 PRTVTL--IPGDGIGPLVTGAVEQVMEAMHAPV------HF----ERYEVLGNMrkVPEEVIESVKRNKVCLKGGLATP- 104
Cdd:PRK03437 2 AKTMKLavIPGDGIGPEVVAEALKVLDAVAAGGpgvettEYdlgaRRYLRTGET--LPDSVLAELRQHDAILLGAIGDPs 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 105 VGGGV--SSLNMQLRKELDIFASLVNCINVPGLVT---RHENVDIVVIRENTEGEYSG--------LEHEVVPGVveslK 171
Cdd:PRK03437 80 VPSGVleRGLLLKLRFALDHYVNLRPSKLYPGVTSplaGPGDIDFVVVREGTEGPYTGnggalrvgTPHEVATEV----S 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 172 VITKFCSERIARYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVM 251
Cdd:PRK03437 156 VNTAFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 252 VTPNLYGNLIANTAAGIAGGTGVMPGGNVGAEHA---IFEQ-GASAgnvgnDKMVEQKKANPVALLLSSAMMLRHLRFPT 327
Cdd:PRK03437 236 VTDNLFGDIITDLAAAVTGGIGLAASGNINPTGTnpsMFEPvHGSA-----PDIAGQGIADPTAAILSVALLLDHLGEED 310
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 15237075 328 FADRLETAVKQVIKEgkyrtkDLGGDCTTQEVVDAVIAAL 367
Cdd:PRK03437 311 AAARIEAAVEADLAE------RGKMGRSTAEVGDRIAARL 344
|
|
| PRK07006 |
PRK07006 |
isocitrate dehydrogenase; Reviewed |
44-341 |
9.58e-58 |
|
isocitrate dehydrogenase; Reviewed
Pssm-ID: 180792 Cd Length: 409 Bit Score: 192.97 E-value: 9.58e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 44 IPGDGIGPLVTGAVEQVMEA--------------MHAPVHFERYEVLGNMRKVPEEVIESVKRNKVCLKGGLATPVGGGV 109
Cdd:PRK07006 25 IEGDGIGPDITPAMLKVVDAavekaykgerkiswMEIYAGEKATKVYGEDVWLPEETLDLIREYRVAIKGPLTTPVGGGI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 110 SSLNMQLRKELDIFASL--VNCIN-VPGLVTRHENVDIVVIRENTEGEYSGLEHEvvPGVVESLKVI------------- 173
Cdd:PRK07006 105 RSLNVALRQELDLYVCLrpVRYFKgVPSPVKRPEDTDMVIFRENSEDIYAGIEWK--AGSAEAKKVIkflqeemgvkkir 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 174 --------TKFCS----ERIARYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSG--------------- 226
Cdd:PRK07006 183 fpetsgigIKPVSeegtERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQLAEEEFGdelidggpwdkiknp 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 227 ITYNEIIVDNCC-----MQLVAKPEQFDVMVTPNLYGNLIANTAAGIAGGTGVMPGGNVGAEHAIFEqgASAGNVgnDKM 301
Cdd:PRK07006 263 ETGKEIIVKDSIadaflQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANINDGHAIFE--ATHGTA--PKY 338
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 15237075 302 VEQKKANPVALLLSSAMMLRHLRFPTFADRLETAVKQVIK 341
Cdd:PRK07006 339 AGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIA 378
|
|
| leuB |
TIGR00169 |
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ... |
41-364 |
1.32e-53 |
|
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 272939 Cd Length: 346 Bit Score: 180.29 E-value: 1.32e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 41 VTLIPGDGIGPLVTGAVEQVMEAMHapvhfERYEVLGNMRK--------------VPEEVIESVKRNKVCLKGGLATPV- 105
Cdd:TIGR00169 2 IAVLPGDGIGPEVMAQALKVLKAVA-----ERFGLKFEFEEhliggaaidatgqpLPEETLKGCKEADAVLLGAVGGPKw 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 106 GGGVSSLN-----MQLRKELDIFASLVNCINVPGLVTRH-------ENVDIVVIRENTEGEYSGLEHEV-VPGVVESLKV 172
Cdd:TIGR00169 77 DNLPRDQRpeqglLKLRKSLDLFANLRPAKVFPGLEDLSplkeeiaKGVDFVVVRELTGGIYFGEPKGReGEGEAWDTEV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 173 ITKFCSERIARYAFEYAyLNNRKKVTAVHKANIMKLADgLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMV 252
Cdd:TIGR00169 157 YTVPEIERIARVAFEMA-RKRRKKVTSVDKANVLESSR-LWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 253 TPNLYGNLIANTAAGIAGGTGVMPGGNVGAE-HAIFE-QGASAgnvgnDKMVEQKKANPVALLLSSAMMLRH-LRFPTFA 329
Cdd:TIGR00169 235 TSNLFGDILSDEASVITGSLGMLPSASLGSDgFGLFEpVHGSA-----PDIAGKGIANPIAQILSAAMLLRYsFNLEEAA 309
|
330 340 350
....*....|....*....|....*....|....*
gi 15237075 330 DRLETAVKQVIKEGkYRTKDLGGDCTTqEVVDAVI 364
Cdd:TIGR00169 310 DAIEAAVKKVLAEG-YRTPDLGSSATT-AVGTAEM 342
|
|
| PRK06451 |
PRK06451 |
NADP-dependent isocitrate dehydrogenase; |
44-368 |
7.07e-53 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 235803 Cd Length: 412 Bit Score: 180.41 E-value: 7.07e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 44 IPGDGIGPLVTGAVEQVMEAMHAPVHFER-----YEVLGNMR-------KVPEEVIESVKRNKVCLKGGLATPVGGGVSS 111
Cdd:PRK06451 29 VEGDGIGPEITHAAMKVINKAVEKAYGSDreikwVEVLAGDKaekltgnRFPKESEELIEKYRVLLKGPLETPIGKGWKS 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 112 LNMQLRKELDIFASLVNCINVPGL---VTRHENVDIVVIRENTEGEYSGLEH--------------------EVVPGVVE 168
Cdd:PRK06451 109 INVAIRLMLDLYANIRPVKYIPGIespLKNPEKIDLIIFRENTDDLYRGIEYpydseeakkirdflrkelgvEVEDDTGI 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 169 SLKVITKFCSERIARYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVA---------------KHYSG------I 227
Cdd:PRK06451 189 GIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAYEVAlkefrdyvvteeevtKNYNGvppsgkV 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 228 TYNEIIVDNCCMQLVAKPEQFDVMVTPNLYGNLIANTAAGIAGGTGVMPGGNVGAEHAIFEqgASAGNVgnDKMVEQKKA 307
Cdd:PRK06451 269 IINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFE--AIHGTA--PKYAGKNVA 344
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15237075 308 NPVALLLSSAMMLRHLRFPTFADRLETAVKQVIKEGKYrTKDLG-----GDCTTQEVVDAVIAALE 368
Cdd:PRK06451 345 NPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQKKV-TQDLArfmgvRALSTTEYTDELISIID 409
|
|
| PRK08194 |
PRK08194 |
tartrate dehydrogenase; Provisional |
40-367 |
1.43e-45 |
|
tartrate dehydrogenase; Provisional
Pssm-ID: 181281 Cd Length: 352 Bit Score: 159.50 E-value: 1.43e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 40 TVTLIPGDGIGPLVTGAVEQVMEAMhAPVH------FERYE-----VLGNMRKVPEEVIESVKRNKVCLKGGLATP--VG 106
Cdd:PRK08194 5 KIAVIPGDGVGKEVVPAAVRVLKAV-AEVHgglkfeFTEFPwsceyYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPklVP 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 107 GGVS--SLNMQLRKELDIF-----ASLVNCINVPglVTRHENVDIVVIRENTEGEYSGL-------EHEVVpgVVESlkV 172
Cdd:PRK08194 84 DHISlwGLLIKIRREFEQVinirpAKQLRGIKSP--LANPKDFDLLVVRENSEGEYSEVggrihrgEDEIA--IQNA--V 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 173 ITKFCSERIARYAFEYAYlNNRKKVTAVHKAN----IMKLADGLFlescREVAKHYSGITYNEIIVDNCCMQLVAKPEQF 248
Cdd:PRK08194 158 FTRKGTERAMRYAFELAA-KRRKHVTSATKSNgivhSMPFWDEVF----QEVGKDYPEIETDSQHIDALAAFFVTRPEEF 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 249 DVMVTPNLYGNLIANTAAGIAGGTGVMPGGNV---GAEHAIFE--QGASAGNVGndkmveQKKANPVALLLSSAMMLRHL 323
Cdd:PRK08194 233 DVIVASNLFGDILTDIGAAIMGSIGIAPAANInvnGKYPSMFEpvHGSAPDIAG------KGIANPIGQIWTAKLMLDHF 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 15237075 324 RFPTFADRLETAVKQVIKEGkYRTKDLGGDCTTQEVVDAVIAAL 367
Cdd:PRK08194 307 GEEELGSHLLDVIEDVTEDG-IKTPDIGGRATTDEVTDEIISRL 349
|
|
| PRK07362 |
PRK07362 |
NADP-dependent isocitrate dehydrogenase; |
41-350 |
6.95e-39 |
|
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 180944 Cd Length: 474 Bit Score: 144.47 E-value: 6.95e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 41 VTLIPGDGIGPLVTGAVEQVMEAMHAPVH--------FERY------EVLGNMRKVPEEVIESVKRNKVCLKGGLATPVG 106
Cdd:PRK07362 31 IPFIRGDGTGVDIWPATQKVLDAAVAKAYggerkinwFKVYagdeacDLYGTYQYLPEDTLEAIREYGVAIKGPLTTPIG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 107 GGVSSLNMQLRKELDIFASLVNCINVPGLVTRH---ENVDIVVIRENTEGEYSGLE----------------HEVVPGVV 167
Cdd:PRK07362 111 GGIRSLNVALRQIFDLYSCVRPCRYYAGTPSPHknpEKLDVIVYRENTEDIYMGIEweagdeigdklikhlnEEVIPASP 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 168 E------------SLKVITKFCSERIARYAFEYAYL--NNRKKVTAVHKANIMKLADGLF-------------------L 214
Cdd:PRK07362 191 ElgkrqiplgsgiGIKPVSKTGSQRHIRRAIEHALRlpGDKRHVTLVHKGNIMKYTEGAFrdwgyelattefrdecvteR 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 215 ES------------------------------------CREV--------AKHYSG-----ITYNEIIVDNCCMQLVAKP 245
Cdd:PRK07362 271 ESwilsnkeknpnisiednarmiepgydsltpekkaaiCAEVkevldsiwSSHGNGkwkekVLVDDRIADSIFQQIQTRP 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 246 EQFDVMVTPNLYGNLIANTAAGIAGGTGVMPGGNVGAEHAIFE--QGASAGNVGNDKMveqkkaNPVALLLSSAMMLRHL 323
Cdd:PRK07362 351 QEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFEatHGTAPKHAGLDRI------NPGSVILSGVMMLEYL 424
|
410 420
....*....|....*....|....*..
gi 15237075 324 RFPTFADRLETAVKQVIKEGKYrTKDL 350
Cdd:PRK07362 425 GWQEAADLITKGLSAAIANKQV-TYDL 450
|
|
| PLN02329 |
PLN02329 |
3-isopropylmalate dehydrogenase |
41-350 |
1.10e-29 |
|
3-isopropylmalate dehydrogenase
Pssm-ID: 215188 Cd Length: 409 Bit Score: 117.87 E-value: 1.10e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 41 VTLIPGDGIGPLVTGAVEQVMEA-----------MHAPVHFERYEVLGnmRKVPEEVIESVKRNKVCLKGGlatpVGGGV 109
Cdd:PLN02329 49 IALLPGDGIGPEVISVAKNVLQKagsleglefdfQEMPVGGAALDLVG--VPLPEETFTAAKQSDAILLGA----IGGYK 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 110 SSLN----------MQLRKELDIFASLVNCINVPGLVTRH-------ENVDIVVIRENTEGEYSGLEHEV-VPGVVESLK 171
Cdd:PLN02329 123 WDKNekhlrpemalFYLRRDLKVFANLRPATVLPQLVDAStlkkevaEGVDMMIVRELTGGIYFGEPRGItINENGEEVG 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 172 VITKFCS----ERIARYAFEYAYlNNRKKVTAVHKANIMKlADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQ 247
Cdd:PLN02329 203 VSTEIYAaheiDRIARVAFETAR-KRRGKLCSVDKANVLD-ASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQ 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15237075 248 FDVMVTPNLYGNLIANTAAGIAGGTGVMPGGNVGAEH-AIFE--QGASAGNVGNDkmveqkKANPVALLLSSAMMLRH-L 323
Cdd:PLN02329 281 FDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEpiHGSAPDIAGQD------KANPLATILSAAMLLKYgL 354
|
330 340
....*....|....*....|....*..
gi 15237075 324 RFPTFADRLETAVKQVIKEGkYRTKDL 350
Cdd:PLN02329 355 GEEKAAKRIEDAVVDALNKG-FRTGDI 380
|
|
| |
