|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
55-403 |
2.79e-25 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 107.69 E-value: 2.79e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 55 LEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFhSGHANNVFQAKFMPfsDDRTIVTCAADGMVRRASIL 134
Cdd:COG2319 116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSP--DGKLLASGSDDGTVRLWDLA 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 135 EGDKVETsfLGLHQGRAHKLCIEPGNPHIFyTCGEDGLVQRFDLRTEAPTELFTcrsvdprrrnMDAIQLNAIAIDPrNS 214
Cdd:COG2319 193 TGKLLRT--LTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLRTLT----------GHSGSVRSVAFSP-DG 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 215 NLFAVGGMEEYARLYDIRRFQgeglngftraadhfcPPHLIGNEDVGITGLAFSEQSELLVS-YNDEFIYLFTPGMGlgs 293
Cdd:COG2319 259 RLLASGSADGTVRLWDLATGE---------------LLRTLTGHSGGVNSVAFSPDGKLLASgSDDGTVRLWDLATG--- 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 294 npipsspiskspvsksesssspkdenehSVSLVYKGHKNceTVKGVNfFGPRSEYVVSGSDCGRIFIWRKKGGELIRVME 373
Cdd:COG2319 321 ----------------------------KLLRTLTGHTG--AVRSVA-FSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
|
330 340 350
....*....|....*....|....*....|
gi 30690225 374 ADRHVVNCIEPHPHIPVLASSGIESDIKVW 403
Cdd:COG2319 370 GHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
55-403 |
8.86e-19 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 86.62 E-value: 8.86e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 55 LEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFhSGHANNVfqAKFMPFSDDRTIVTCAADGMVRRASiL 134
Cdd:cd00200 5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPV--RDVAASADGTYLASGSSDKTIRLWD-L 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 135 EGDKVETSFLGlHQGRAHKLCIEPgNPHIFYTCGEDGLVQRFDLRTEAPTELFTCRSvdprrrnmDAIqlNAIAIDPrnS 214
Cdd:cd00200 81 ETGECVRTLTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHT--------DWV--NSVAFSP--D 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 215 NLFAVGGMEE-YARLYDIRRFQGEGLngftraadhfcpphLIGNEDvGITGLAFSEQ-SELLVSYNDEFIYLFTPGMGlg 292
Cdd:cd00200 147 GTFVASSSQDgTIKLWDLRTGKCVAT--------------LTGHTG-EVNSVAFSPDgEKLLSSSSDGTIKLWDLSTG-- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 293 snpipsspiskspvsksesssspkdenehSVSLVYKGHKNcetvkGVNF--FGPRSEYVVSGSDCGRIFIWRKKGGELIR 370
Cdd:cd00200 210 -----------------------------KCLGTLRGHEN-----GVNSvaFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255
|
330 340 350
....*....|....*....|....*....|...
gi 30690225 371 VMEADRHVVNCIEPHPHIPVLASSGIESDIKVW 403
Cdd:cd00200 256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
50-87 |
2.68e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 43.87 E-value: 2.68e-06
10 20 30
....*....|....*....|....*....|....*...
gi 30690225 50 EIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWD 87
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
53-87 |
2.86e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 43.84 E-value: 2.86e-06
10 20 30
....*....|....*....|....*....|....*
gi 30690225 53 KKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWD 87
Cdd:smart00320 6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
55-403 |
2.79e-25 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 107.69 E-value: 2.79e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 55 LEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFhSGHANNVFQAKFMPfsDDRTIVTCAADGMVRRASIL 134
Cdd:COG2319 116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSP--DGKLLASGSDDGTVRLWDLA 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 135 EGDKVETsfLGLHQGRAHKLCIEPGNPHIFyTCGEDGLVQRFDLRTEAPTELFTcrsvdprrrnMDAIQLNAIAIDPrNS 214
Cdd:COG2319 193 TGKLLRT--LTGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLRTLT----------GHSGSVRSVAFSP-DG 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 215 NLFAVGGMEEYARLYDIRRFQgeglngftraadhfcPPHLIGNEDVGITGLAFSEQSELLVS-YNDEFIYLFTPGMGlgs 293
Cdd:COG2319 259 RLLASGSADGTVRLWDLATGE---------------LLRTLTGHSGGVNSVAFSPDGKLLASgSDDGTVRLWDLATG--- 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 294 npipsspiskspvsksesssspkdenehSVSLVYKGHKNceTVKGVNfFGPRSEYVVSGSDCGRIFIWRKKGGELIRVME 373
Cdd:COG2319 321 ----------------------------KLLRTLTGHTG--AVRSVA-FSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
|
330 340 350
....*....|....*....|....*....|
gi 30690225 374 ADRHVVNCIEPHPHIPVLASSGIESDIKVW 403
Cdd:COG2319 370 GHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
40-276 |
5.61e-19 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 88.81 E-value: 5.61e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 40 SASENLVLRL------EIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFHsGHANNVFQAKFMPf 113
Cdd:COG2319 179 SGSDDGTVRLwdlatgKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT-GHSGSVRSVAFSP- 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 114 sDDRTIVTCAADGMVRRASILEGDKVETsfLGLHQGRAHKLCIEPGNPHIFyTCGEDGLVQRFDLRTEAPTELFTCRSVD 193
Cdd:COG2319 257 -DGRLLASGSADGTVRLWDLATGELLRT--LTGHSGGVNSVAFSPDGKLLA-SGSDDGTVRLWDLATGKLLRTLTGHTGA 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 194 PRrrnmdaiqlnAIAIDPrNSNLFAVGGMEEYARLYDIRRFQgeglngftraadhfCPPHLIGNEDvGITGLAFSEQSEL 273
Cdd:COG2319 333 VR----------SVAFSP-DGKTLASGSDDGTVRLWDLATGE--------------LLRTLTGHTG-AVTSVAFSPDGRT 386
|
...
gi 30690225 274 LVS 276
Cdd:COG2319 387 LAS 389
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
5-403 |
6.32e-19 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 88.81 E-value: 6.32e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 5 ARRGRSNFNGLHHPVVDFWRREVGGISSRNFSNRFSASENLVLRLEIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVV 84
Cdd:COG2319 24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 85 LWDWQLGNVKLSFHsGHANNVFQAKFMPfsDDRTIVTCAADGMVRRASILEGDKVETsfLGLHQGRAHKLCIEPGNpHIF 164
Cdd:COG2319 104 LWDLATGLLLRTLT-GHTGAVRSVAFSP--DGKTLASGSADGTVRLWDLATGKLLRT--LTGHSGAVTSVAFSPDG-KLL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 165 YTCGEDGLVQRFDLRTEAPTELFTCRSvdprrrnmDAIqlNAIAIDPrNSNLFAVGGMEEYARLYDIRRFQgeglngftr 244
Cdd:COG2319 178 ASGSDDGTVRLWDLATGKLLRTLTGHT--------GAV--RSVAFSP-DGKLLASGSADGTVRLWDLATGK--------- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 245 aadhfcPPHLIGNEDVGITGLAFSEQSELLVS-YNDEFIYLF--TPGMGLGSNPIPSSPIskspvsksesssspkdeneH 321
Cdd:COG2319 238 ------LLRTLTGHSGSVRSVAFSPDGRLLASgSADGTVRLWdlATGELLRTLTGHSGGV-------------------N 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 322 SVSlvykghkncetvkgvnfFGPRSEYVVSGSDCGRIFIWRKKGGELIRVMEADRHVVNCIEPHPHIPVLASSGIESDIK 401
Cdd:COG2319 293 SVA-----------------FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355
|
..
gi 30690225 402 VW 403
Cdd:COG2319 356 LW 357
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
55-403 |
8.86e-19 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 86.62 E-value: 8.86e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 55 LEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFhSGHANNVfqAKFMPFSDDRTIVTCAADGMVRRASiL 134
Cdd:cd00200 5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPV--RDVAASADGTYLASGSSDKTIRLWD-L 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 135 EGDKVETSFLGlHQGRAHKLCIEPgNPHIFYTCGEDGLVQRFDLRTEAPTELFTCRSvdprrrnmDAIqlNAIAIDPrnS 214
Cdd:cd00200 81 ETGECVRTLTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHT--------DWV--NSVAFSP--D 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 215 NLFAVGGMEE-YARLYDIRRFQGEGLngftraadhfcpphLIGNEDvGITGLAFSEQ-SELLVSYNDEFIYLFTPGMGlg 292
Cdd:cd00200 147 GTFVASSSQDgTIKLWDLRTGKCVAT--------------LTGHTG-EVNSVAFSPDgEKLLSSSSDGTIKLWDLSTG-- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 293 snpipsspiskspvsksesssspkdenehSVSLVYKGHKNcetvkGVNF--FGPRSEYVVSGSDCGRIFIWRKKGGELIR 370
Cdd:cd00200 210 -----------------------------KCLGTLRGHEN-----GVNSvaFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255
|
330 340 350
....*....|....*....|....*....|...
gi 30690225 371 VMEADRHVVNCIEPHPHIPVLASSGIESDIKVW 403
Cdd:cd00200 256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
26-285 |
5.54e-18 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 84.31 E-value: 5.54e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 26 EVGGISSRNFSNR-FSASENLVLRL------EIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFH 98
Cdd:cd00200 53 PVRDVAASADGTYlASGSSDKTIRLwdletgECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLR 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 99 sGHANNVFQAKFMPfsDDRTIVTCAADGMVRrasI--LEGDKVETSFLGlHQGRAHKLCIEPGNPHIFyTCGEDGLVQRF 176
Cdd:cd00200 133 -GHTDWVNSVAFSP--DGTFVASSSQDGTIK---LwdLRTGKCVATLTG-HTGEVNSVAFSPDGEKLL-SSSSDGTIKLW 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 177 DLRTEAPTELFTCRSVdprrrnmdaiQLNAIAIDPrNSNLFAVGGMEEYARLYDIRRFQgeglngftraadhfCPPHLIG 256
Cdd:cd00200 205 DLSTGKCLGTLRGHEN----------GVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGE--------------CVQTLSG 259
|
250 260 270
....*....|....*....|....*....|
gi 30690225 257 NEDvGITGLAFSEQSELLVS-YNDEFIYLF 285
Cdd:cd00200 260 HTN-SVTSLAWSPDGKRLASgSADGTIRIW 288
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
39-280 |
6.98e-15 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 75.06 E-value: 6.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 39 FSASENLVLRL------EIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFHsGHANNVFQAKFMP 112
Cdd:cd00200 25 ATGSGDGTIKVwdletgELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT-GHTSYVSSVAFSP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 113 fsDDRTIVTCAADGMVRRASILEGdKVETSFLGlHQGRAHKLCIEPGNPHIFyTCGEDGLVQRFDLRTEAPTELFTCRSV 192
Cdd:cd00200 104 --DGRILSSSSRDKTIKVWDVETG-KCLTTLRG-HTDWVNSVAFSPDGTFVA-SSSQDGTIKLWDLRTGKCVATLTGHTG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 193 DprrrnmdaiqLNAIAIDPrNSNLFAVGGMEEYARLYDIRRFQGEGLngftraadhfcpphLIGNEDvGITGLAFSEQSE 272
Cdd:cd00200 179 E----------VNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGT--------------LRGHEN-GVNSVAFSPDGY 232
|
....*...
gi 30690225 273 LLVSYNDE 280
Cdd:cd00200 233 LLASGSED 240
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
40-129 |
5.79e-11 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 64.16 E-value: 5.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 40 SASENLVLRL------EIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFhSGHANNVFQAKFMPf 113
Cdd:COG2319 305 SGSDDGTVRLwdlatgKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-TGHTGAVTSVAFSP- 382
|
90
....*....|....*.
gi 30690225 114 sDDRTIVTCAADGMVR 129
Cdd:COG2319 383 -DGRTLASGSADGTVR 397
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
66-403 |
1.27e-09 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 59.92 E-value: 1.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 66 SFNAEGDVLISGSDDRRVVLWDWQLGNVKLSFHSGHANNVFQAkfmPFSDDRTIVTCAADGMVRRASILEGDKVETsfLG 145
Cdd:COG2319 1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLA---ASPDGARLAAGAGDLTLLLLDAAAGALLAT--LL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 146 LHQGRAHKLCIEPGNPHIfYTCGEDGLVQRFDLRTEAPTELFTCRSvdprrrnmDAIqlNAIAIDPrNSNLFAVGGMEEY 225
Cdd:COG2319 76 GHTAAVLSVAFSPDGRLL-ASASADGTVRLWDLATGLLLRTLTGHT--------GAV--RSVAFSP-DGKTLASGSADGT 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 226 ARLYDirrfqgeglngftrAADHFCPPHLIGNEDvGITGLAFSEQSELLVS-YNDEFIYLFtpgmglgsnpipsspisks 304
Cdd:COG2319 144 VRLWD--------------LATGKLLRTLTGHSG-AVTSVAFSPDGKLLASgSDDGTVRLW------------------- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 305 pvsksesssspkDENEHSVSLVYKGHKNceTVKGVNFfGPRSEYVVSGSDCGRIFIWRKKGGELIRVMEADRHVVNCIEP 384
Cdd:COG2319 190 ------------DLATGKLLRTLTGHTG--AVRSVAF-SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF 254
|
330
....*....|....*....
gi 30690225 385 HPHIPVLASSGIESDIKVW 403
Cdd:COG2319 255 SPDGRLLASGSADGTVRLW 273
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
50-87 |
2.68e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 43.87 E-value: 2.68e-06
10 20 30
....*....|....*....|....*....|....*...
gi 30690225 50 EIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWD 87
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
53-87 |
2.86e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 43.84 E-value: 2.86e-06
10 20 30
....*....|....*....|....*....|....*
gi 30690225 53 KKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWD 87
Cdd:smart00320 6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
40-89 |
3.13e-05 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 46.06 E-value: 3.13e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 30690225 40 SASENLVLRL------EIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWDWQ 89
Cdd:COG2319 347 SGSDDGTVRLwdlatgELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
326-403 |
7.99e-05 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 44.63 E-value: 7.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 326 VYKGHKncetvKGVNF--FGPRSEYVVSGSDCGRIFIWRKKGGELIRVMEADRHVVNCIEPHPHIPVLASSGIESDIKVW 403
Cdd:cd00200 4 TLKGHT-----GGVTCvaFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
326-414 |
1.47e-04 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 44.13 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30690225 326 VYKGHKNceTVKGVNFFgPRSEYVVSGSDCGRIFIWRKKGGELIRVMEADRHVVNCIEPHPHIPVLASSGIESDIKVW-T 404
Cdd:COG2319 157 TLTGHSG--AVTSVAFS-PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWdL 233
|
90
....*....|
gi 30690225 405 SKAAERATLP 414
Cdd:COG2319 234 ATGKLLRTLT 243
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
39-87 |
8.84e-03 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 38.08 E-value: 8.84e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 30690225 39 FSASENLVLRL------EIYKKLEKHKGCVNTVSFNAEGDVLISGSDDRRVVLWD 87
Cdd:cd00200 235 ASGSEDGTIRVwdlrtgECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| |
