Alkaline-phosphatase-like family protein [Arabidopsis thaliana]
Protein Classification
nucleotide pyrophosphatase/phosphodiesterase family protein( domain architecture ID 12025720)
nucleotide pyrophosphatase/phosphodiesterase family protein catalyzes the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and/or nucleotide sugars; belongs to the alkaline phosphatase superfamily
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| Phosphodiest | pfam01663 | Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of ... |
60-394 | 3.46e-119 | ||||||
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum. : Pssm-ID: 396300 [Multi-domain] Cd Length: 343 Bit Score: 352.11 E-value: 3.46e-119
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| Name | Accession | Description | Interval | E-value | ||||||
| Phosphodiest | pfam01663 | Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of ... |
60-394 | 3.46e-119 | ||||||
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum. Pssm-ID: 396300 [Multi-domain] Cd Length: 343 Bit Score: 352.11 E-value: 3.46e-119
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| Enpp | cd16018 | Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide ... |
58-434 | 5.60e-95 | ||||||
Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles. Pssm-ID: 293742 [Multi-domain] Cd Length: 267 Bit Score: 287.17 E-value: 5.60e-95
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| AtaC | COG1524 | c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal ... |
60-435 | 6.27e-70 | ||||||
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal transduction mechanisms]; Pssm-ID: 441133 [Multi-domain] Cd Length: 370 Bit Score: 226.55 E-value: 6.27e-70
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| Name | Accession | Description | Interval | E-value | ||||||
| Phosphodiest | pfam01663 | Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of ... |
60-394 | 3.46e-119 | ||||||
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum. Pssm-ID: 396300 [Multi-domain] Cd Length: 343 Bit Score: 352.11 E-value: 3.46e-119
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| Enpp | cd16018 | Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide ... |
58-434 | 5.60e-95 | ||||||
Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; Ecto-nucleotide pyrophosphatases/phosphodiesterases (ENPPs) hydrolyze 5'-phosphodiester bonds in nucleotides and their derivatives, resulting in the release of 5'-nucleotide monophosphates. ENPPs have multiple physiological roles, including nucleotide recycling, modulation of purinergic receptor signaling, regulation of extracellular pyrophosphate levels, stimulation of cell motility, and possible roles in regulation of insulin receptor (IR) signaling and activity of ecto-kinases. The eukaryotic ENPP family contains at least five members that have different tissue distribution and physiological roles. Pssm-ID: 293742 [Multi-domain] Cd Length: 267 Bit Score: 287.17 E-value: 5.60e-95
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| AtaC | COG1524 | c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal ... |
60-435 | 6.27e-70 | ||||||
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal transduction mechanisms]; Pssm-ID: 441133 [Multi-domain] Cd Length: 370 Bit Score: 226.55 E-value: 6.27e-70
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| ALP_like | cd00016 | alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ... |
57-271 | 8.79e-26 | ||||||
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases. Pssm-ID: 293732 [Multi-domain] Cd Length: 237 Bit Score: 105.20 E-value: 8.79e-26
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| sulfatase_like | cd16148 | uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
60-270 | 3.41e-13 | ||||||
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293767 [Multi-domain] Cd Length: 271 Bit Score: 69.50 E-value: 3.41e-13
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| AslA | COG3119 | Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism]; |
57-270 | 5.34e-08 | ||||||
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism]; Pssm-ID: 442353 [Multi-domain] Cd Length: 393 Bit Score: 54.88 E-value: 5.34e-08
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| SGSH | cd16027 | N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ... |
60-272 | 8.33e-08 | ||||||
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities. Pssm-ID: 293751 [Multi-domain] Cd Length: 373 Bit Score: 54.05 E-value: 8.33e-08
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| Sulfatase | pfam00884 | Sulfatase; |
59-270 | 1.47e-07 | ||||||
Sulfatase; Pssm-ID: 459979 [Multi-domain] Cd Length: 298 Bit Score: 52.81 E-value: 1.47e-07
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| sulfatase_like | cd16022 | sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ... |
60-270 | 1.49e-07 | ||||||
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293746 [Multi-domain] Cd Length: 236 Bit Score: 52.05 E-value: 1.49e-07
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| sulfatase_like | cd16034 | uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
57-270 | 4.94e-07 | ||||||
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293758 [Multi-domain] Cd Length: 399 Bit Score: 51.80 E-value: 4.94e-07
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| ARS_like | cd16144 | uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
63-270 | 1.85e-06 | ||||||
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293763 [Multi-domain] Cd Length: 421 Bit Score: 49.85 E-value: 1.85e-06
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| AP-SPAP | cd16016 | SPAP is a subclass of alkaline phosphatase (AP); Alkaline phosphatases are non-specific ... |
84-133 | 1.71e-05 | ||||||
SPAP is a subclass of alkaline phosphatase (AP); Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Although SPAP is a subclass of alkaline phosphatase, SPAP has many differences from other APs: 1) the catalytic residue is a threonine instead of serine, 2) there is no binding pocket for the third metal ion, and 3) the arginine residue forming bidentate hydrogen bonding is deleted in SPAP. A lysine and an asparagine residue, recruited together for the first time into the active site, bind the substrate phosphoryl group in a manner not observed before in any other AP. Pssm-ID: 293740 [Multi-domain] Cd Length: 457 Bit Score: 47.14 E-value: 1.71e-05
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| GPI_EPT_3 | cd16023 | GPI ethanolamine phosphate transferase 3, PIG-O; Ethanolamine phosphate transferase is ... |
198-271 | 2.09e-04 | ||||||
GPI ethanolamine phosphate transferase 3, PIG-O; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation. Pssm-ID: 293747 Cd Length: 289 Bit Score: 42.93 E-value: 2.09e-04
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| GPI_EPT | cd16019 | GPI ethanolamine phosphate transferase; Ethanolamine phosphate transferase is involved in ... |
201-271 | 4.38e-04 | ||||||
GPI ethanolamine phosphate transferase; Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation. Pssm-ID: 293743 [Multi-domain] Cd Length: 292 Bit Score: 41.96 E-value: 4.38e-04
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| sulfatase_like | cd16150 | uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
238-270 | 9.42e-04 | ||||||
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293769 [Multi-domain] Cd Length: 423 Bit Score: 41.45 E-value: 9.42e-04
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| ARS_like | cd16145 | uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
204-270 | 8.94e-03 | ||||||
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases. Pssm-ID: 293764 [Multi-domain] Cd Length: 415 Bit Score: 38.34 E-value: 8.94e-03
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