|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
30-468 |
5.21e-140 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 409.65 E-value: 5.21e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 30 ELKLQMRIGLPLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFSFANVTGFSVLYGISAAMEPICGQAFGAKNFKLLH 109
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 110 KTLFMAVLLLLLISVPISFLWLNVHKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFTTAA 189
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 190 ATSLHIPINIVL--SKARGIEGVAMAVWITDFIVVILLTGYVIVVermKENKWKQGGWLNQSAQDWLTLIKLSGPCCLTV 267
Cdd:cd13132 161 ALLLNILLNYLLvfVLGLGFIGAALATSISYWLIVVLLLLYIFFS---KGHKATWGGFSREAFRGWGPFLKLAIPSALML 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 268 CLEWWCYEILVLLTGRLPnPVQAVSILIIVFNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVGIISGC 347
Cdd:cd13132 238 CLEWWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 348 IGALVMIAFRGFWGSLYThHDQLILNGVKKMMLIMAVIEVVNFPLMVCGEIVRGTAKPSLGMYANLSGFYLLALPLGATL 427
Cdd:cd13132 317 VVAILLLVLRDVWAYLFT-SDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLL 395
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 15235794 428 AFKAKQGLQGFLIGLFVGISLCLSILLIFIARIDWEKEAGK 468
Cdd:cd13132 396 AFVLGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
36-456 |
1.13e-36 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 140.28 E-value: 1.13e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 36 RIGLPLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFSFANVTgFSVLYGISAAMEPICGQAFGAKNFKLLHKTLFMA 115
Cdd:COG0534 12 RLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARRVLGQA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 116 VLLLLLISVPISFL-WLNVHKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFTTAAATSLH 194
Cdd:COG0534 91 LLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGNVLN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 195 IPINIVLSK--ARGIEGVAMAVWITDFIVVILLTGYVIVVERMKENKWKQGGWlnqSAQDWLTLIKLSGPCCLTVCLEWW 272
Cdd:COG0534 171 IVLDPLLIFggGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRP---DRKILKRILRIGLPAGLQQLAESL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 273 CYEILVLLTGRLPnpVQAVSILIIVFNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVGIISGCIGALV 352
Cdd:COG0534 248 GFLVLNALVARLG--TAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 353 MIAFRGFWGSLYTHHDQLILNGVkKMMLIMAVIEVVNFPLMVCGEIVRGTAKPSLGMYANLSGFYLLALPLGATLAFkAK 432
Cdd:COG0534 326 LFLFPEPIIGLFTDDPEVIALAA-TYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF-LG 403
|
410 420
....*....|....*....|....
gi 15235794 433 QGLQGFLIGLFVGISLCLSILLIF 456
Cdd:COG0534 404 LGLTGVWLALPIGEVLRALLLLLR 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
40-383 |
1.52e-31 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 123.89 E-value: 1.52e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 40 PLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFSFaNVTGFSVLYGISAAMEPICGQAFGAKNFKLLHKTLFMAVLLL 119
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSV-FMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 120 LLISVPISFLWLNVHKILTGFGQRED-ISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFTTAAATSLHIPIN 198
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGeVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 199 IVLSKAR----GIEGVAMAVWITDFIVVILLTGYVIvveRMKENKWKQGGWLNQSAQDWLTLIKLSGPCCLTVCLEWWCY 274
Cdd:TIGR00797 160 YILIFGKfgflGIVGAALATVISYWLMFLLLLYYIK---KAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 275 EILVLLTGRL-PNPVQAVSILIivfNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVGIISGCIGALVM 353
Cdd:TIGR00797 237 ALLALLVARLgSIALAAHQIAL---NVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIIL 313
|
330 340 350
....*....|....*....|....*....|
gi 15235794 354 IAFRGFWGSLYTHHDQlILNGVKKMMLIMA 383
Cdd:TIGR00797 314 ILFREFIARLFTNDPE-VLELAAIYLIFVA 342
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
262-426 |
4.05e-29 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 112.27 E-value: 4.05e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 262 PCCLTVCLEWWCYEILVLLTGRLPnpVQAVSILIIVFNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIV 341
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLG--AVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLIL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 342 GIISGCIGALVMIAFRGFWGSLYTHHDQlILNGVKKMMLIMAVIEVVNFPLMVCGEIVRGTAKPSLGMYANLSGfYLLAL 421
Cdd:pfam01554 79 GLLLSLPIALLVLLFSEPILSLFGQDEE-VLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNI 156
|
....*
gi 15235794 422 PLGAT 426
Cdd:pfam01554 157 PLNYL 161
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
24-460 |
2.15e-24 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 105.67 E-value: 2.15e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 24 MQSIVHELKLQMRIGLPLVVmnllwfGKMTTTS------VFLGRQGELNLAGGSLGFSFAnVTGFSVLYGISAAMEPICG 97
Cdd:PRK01766 4 TQKYKSEARQLLALALPILL------AQVAQTAmgfvdtVMAGGVSATDLAAVAIGTSIW-LPVILFGHGLLLALTPIVA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 98 QAFGAKNFKLLHKTLFMAVLLLLLISVPISF-LWLNVHKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSS 176
Cdd:PRK01766 77 QLNGAGRRERIAHQVRQGLWLALFLSVLIMLvLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 177 QGVTLPIMFTTAAATSLHIPINIVL------SKARGIEGVAMAVWITDFIVVILLTGYVIVVERMKENKWKQGgWLNQSA 250
Cdd:PRK01766 157 LGKTKPTMVIGFLGLLINIPLNYIFiygkfgFPELGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLFKG-LYKPDW 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 251 QDWLTLIKLSGPCCLTVCLEWWCYEILVLLTGRL-PNPVQAVSILIivfNFDYLLYAVMLSLGTCVATRVSNELGANNPK 329
Cdd:PRK01766 236 AVIKRLLKLGLPIGLAIFFEVSLFAVVTLLVSPLgTVTVAAHQIAL---NFSSLLFMLPLSLAMALTIRVGFELGAGRTL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 330 GAYRAAYTTLIVGIISGCIGALVMIAFRGFWGSLYThHDQLILNGVKKMMLIMAVIEVVNFPLMVCGEIVRGTAKPSLGM 409
Cdd:PRK01766 313 DARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYT-DDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIF 391
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 15235794 410 YANLSGFYLLALPLGATLAFKAKQGLQGFLIGLFVGISLCLSILLIFIARI 460
Cdd:PRK01766 392 FITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLLRLRKL 442
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
30-468 |
5.21e-140 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 409.65 E-value: 5.21e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 30 ELKLQMRIGLPLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFSFANVTGFSVLYGISAAMEPICGQAFGAKNFKLLH 109
Cdd:cd13132 1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 110 KTLFMAVLLLLLISVPISFLWLNVHKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFTTAA 189
Cdd:cd13132 81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 190 ATSLHIPINIVL--SKARGIEGVAMAVWITDFIVVILLTGYVIVVermKENKWKQGGWLNQSAQDWLTLIKLSGPCCLTV 267
Cdd:cd13132 161 ALLLNILLNYLLvfVLGLGFIGAALATSISYWLIVVLLLLYIFFS---KGHKATWGGFSREAFRGWGPFLKLAIPSALML 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 268 CLEWWCYEILVLLTGRLPnPVQAVSILIIVFNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVGIISGC 347
Cdd:cd13132 238 CLEWWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 348 IGALVMIAFRGFWGSLYThHDQLILNGVKKMMLIMAVIEVVNFPLMVCGEIVRGTAKPSLGMYANLSGFYLLALPLGATL 427
Cdd:cd13132 317 VVAILLLVLRDVWAYLFT-SDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLL 395
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 15235794 428 AFKAKQGLQGFLIGLFVGISLCLSILLIFIARIDWEKEAGK 468
Cdd:cd13132 396 AFVLGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
30-462 |
3.07e-43 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 158.43 E-value: 3.07e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 30 ELKLQMRIGLPLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFSFANVTgFSVLYGISAAMEPICGQAFGAKNFKLLH 109
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPV-FTFGMGLLLAVTPLVAQAHGAGDRRRIR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 110 KTLFMAVLLLLLISVPISFLWLNVHKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFTTAA 189
Cdd:cd13131 80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 190 ATSLHIPINIVLSK------ARGIEGVAMAVWITDFIVVILLTGYVIVVERMKENKwKQGGWLNQSAQDWLTLIKLSGPC 263
Cdd:cd13131 160 ALVLNIPLNYVLIFgkfglpALGGAGAGLATAIVYWLMFLALAFYIRRHKRFRRYR-LFARFWRPDWARLKELLRLGLPI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 264 CLTVCLEWWCYEILVLLTGRL-PNPVQAVSiliIVFNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVG 342
Cdd:cd13131 239 GLTIFFEVSLFAAVALLMGRLgTTVLAAHQ---IALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 343 IISGCIGALVMIAFRGFWGSLYThHDQLILNGVKKMMLIMAVIEVVNFPLMVCGEIVRGTAKPSLGMYANLSGFYLLALP 422
Cdd:cd13131 316 VGFAALTALLLLLFPEQIAGLYT-NDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLP 394
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 15235794 423 LGATLAFKAKQGLQGFLIGLFVGISLCLSILLIFIARIDW 462
Cdd:cd13131 395 LGYLLAFTTGLGAFGVWIGLIIGLALAAILLLWRFRRLQR 434
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
36-456 |
1.13e-36 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 140.28 E-value: 1.13e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 36 RIGLPLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFSFANVTgFSVLYGISAAMEPICGQAFGAKNFKLLHKTLFMA 115
Cdd:COG0534 12 RLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLL-IALGIGLGVGGTALVAQALGAGDREEARRVLGQA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 116 VLLLLLISVPISFL-WLNVHKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFTTAAATSLH 194
Cdd:COG0534 91 LLLALLLGLLLTLLgLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGNVLN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 195 IPINIVLSK--ARGIEGVAMAVWITDFIVVILLTGYVIVVERMKENKWKQGGWlnqSAQDWLTLIKLSGPCCLTVCLEWW 272
Cdd:COG0534 171 IVLDPLLIFggGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRP---DRKILKRILRIGLPAGLQQLAESL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 273 CYEILVLLTGRLPnpVQAVSILIIVFNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVGIISGCIGALV 352
Cdd:COG0534 248 GFLVLNALVARLG--TAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALL 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 353 MIAFRGFWGSLYTHHDQLILNGVkKMMLIMAVIEVVNFPLMVCGEIVRGTAKPSLGMYANLSGFYLLALPLGATLAFkAK 432
Cdd:COG0534 326 LFLFPEPIIGLFTDDPEVIALAA-TYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF-LG 403
|
410 420
....*....|....*....|....
gi 15235794 433 QGLQGFLIGLFVGISLCLSILLIF 456
Cdd:COG0534 404 LGLTGVWLALPIGEVLRALLLLLR 427
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
40-383 |
1.52e-31 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 123.89 E-value: 1.52e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 40 PLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFSFaNVTGFSVLYGISAAMEPICGQAFGAKNFKLLHKTLFMAVLLL 119
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSV-FMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 120 LLISVPISFLWLNVHKILTGFGQRED-ISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFTTAAATSLHIPIN 198
Cdd:TIGR00797 80 LLLGLPVLLVGYFFIDPLLSLMGADGeVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 199 IVLSKAR----GIEGVAMAVWITDFIVVILLTGYVIvveRMKENKWKQGGWLNQSAQDWLTLIKLSGPCCLTVCLEWWCY 274
Cdd:TIGR00797 160 YILIFGKfgflGIVGAALATVISYWLMFLLLLYYIK---KAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 275 EILVLLTGRL-PNPVQAVSILIivfNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVGIISGCIGALVM 353
Cdd:TIGR00797 237 ALLALLVARLgSIALAAHQIAL---NVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIIL 313
|
330 340 350
....*....|....*....|....*....|
gi 15235794 354 IAFRGFWGSLYTHHDQlILNGVKKMMLIMA 383
Cdd:TIGR00797 314 ILFREFIARLFTNDPE-VLELAAIYLIFVA 342
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
262-426 |
4.05e-29 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 112.27 E-value: 4.05e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 262 PCCLTVCLEWWCYEILVLLTGRLPnpVQAVSILIIVFNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIV 341
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLG--AVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLIL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 342 GIISGCIGALVMIAFRGFWGSLYTHHDQlILNGVKKMMLIMAVIEVVNFPLMVCGEIVRGTAKPSLGMYANLSGfYLLAL 421
Cdd:pfam01554 79 GLLLSLPIALLVLLFSEPILSLFGQDEE-VLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNI 156
|
....*
gi 15235794 422 PLGAT 426
Cdd:pfam01554 157 PLNYL 161
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
39-457 |
7.30e-25 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 106.64 E-value: 7.30e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 39 LPLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFSFANvTGFSVLYGISAAMEPICGQAFGAKNFKLLHKTLFMAVLL 118
Cdd:cd12082 2 APLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIA-LLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 119 LLLISVPIS-FLWLNVHKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFTTAAATSLHIP- 196
Cdd:cd12082 81 AILLGLLLAaLLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILl 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 197 ----INIVLSKARGIEGVAMAVWITDFIVVILLTGYVIVVERMKENKWKQGGWlnqSAQDWLTLIKLSGPCCLTVCLEWW 272
Cdd:cd12082 161 dpllIFGLGPPELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKP---DLELLRRLLRIGLPSAIQNSLLSL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 273 CYEILVLLTGRLPNPVqAVSILIIVFNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVGIISGCIGALV 352
Cdd:cd12082 238 GLLIIVAIVAAFGGAA-ALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 353 MIAFRGFWGSLYTHHDQLILNGVkKMMLIMAVIEVVNFPLMVCGEIVRGTAKPSLGMYANLSGFYLLALPLGATLAFkAK 432
Cdd:cd12082 317 ILLFPEPILSLFTNDPEFLELAV-SYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAY-LG 394
|
410 420
....*....|....*....|....*
gi 15235794 433 QGLQGFLIGLFVGISLCLSILLIFI 457
Cdd:cd12082 395 LGLYGIWLALVISLILAALVLLLFF 419
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
24-460 |
2.15e-24 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 105.67 E-value: 2.15e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 24 MQSIVHELKLQMRIGLPLVVmnllwfGKMTTTS------VFLGRQGELNLAGGSLGFSFAnVTGFSVLYGISAAMEPICG 97
Cdd:PRK01766 4 TQKYKSEARQLLALALPILL------AQVAQTAmgfvdtVMAGGVSATDLAAVAIGTSIW-LPVILFGHGLLLALTPIVA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 98 QAFGAKNFKLLHKTLFMAVLLLLLISVPISF-LWLNVHKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSS 176
Cdd:PRK01766 77 QLNGAGRRERIAHQVRQGLWLALFLSVLIMLvLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 177 QGVTLPIMFTTAAATSLHIPINIVL------SKARGIEGVAMAVWITDFIVVILLTGYVIVVERMKENKWKQGgWLNQSA 250
Cdd:PRK01766 157 LGKTKPTMVIGFLGLLINIPLNYIFiygkfgFPELGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLFKG-LYKPDW 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 251 QDWLTLIKLSGPCCLTVCLEWWCYEILVLLTGRL-PNPVQAVSILIivfNFDYLLYAVMLSLGTCVATRVSNELGANNPK 329
Cdd:PRK01766 236 AVIKRLLKLGLPIGLAIFFEVSLFAVVTLLVSPLgTVTVAAHQIAL---NFSSLLFMLPLSLAMALTIRVGFELGAGRTL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 330 GAYRAAYTTLIVGIISGCIGALVMIAFRGFWGSLYThHDQLILNGVKKMMLIMAVIEVVNFPLMVCGEIVRGTAKPSLGM 409
Cdd:PRK01766 313 DARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYT-DDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIF 391
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 15235794 410 YANLSGFYLLALPLGATLAFKAKQGLQGFLIGLFVGISLCLSILLIFIARI 460
Cdd:PRK01766 392 FITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLLRLRKL 442
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
40-200 |
2.52e-24 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 98.79 E-value: 2.52e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 40 PLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFSFANVTgFSVLYGISAAMEPICGQAFGAKNFKLLHKTLFMAVLLL 119
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLI-FMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 120 LLISVPISFL-WLNVHKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFTTAAATSLHIPIN 198
Cdd:pfam01554 80 LLLSLPIALLvLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159
|
..
gi 15235794 199 IV 200
Cdd:pfam01554 160 YL 161
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
35-462 |
4.84e-22 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 98.35 E-value: 4.84e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 35 MRIGLPLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFSFANVTgFSVLYGISAAMEPICGQAFGAKNFKLLHKTLFM 114
Cdd:cd13137 4 WSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLL-LVLNMALGTGTVALVSQSYGAGDYERARRALGQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 115 AVLLLLLISVPISFL-WLNVHKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFTTAAATSL 193
Cdd:cd13137 83 SLLLALLLSLPLALLgLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 194 HIPINIVL------SKARGIEGVAMAVWITDFIVVILLTgYVIVVERMKENKWKQGGWLNQSaqDWLTLIKLSGPCCLTV 267
Cdd:cd13137 163 NIVLDYVLifglwgFPGLGVAGAALATVISRVVGALLLL-FLLLRGRLPIKISFKGFRLDRK--IIKKLLRIGLPAGLEQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 268 CLEWWCYEILVLLTGRLPNPVQAVsiLIIVFNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVGIISGC 347
Cdd:cd13137 240 LLRSLGFLVLLAIVASYGTAALAA--YQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 348 IGALVMIAFRGFWGSLYTHHDQLILNGVkKMMLIMAVIEVVNFPLMVCGEIVRGTAKPSLGMYANLSGFYLLALPLGATL 427
Cdd:cd13137 318 LLGLLLFIFAPPLASLFTPDPEVIELGV-LYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLL 396
|
410 420 430
....*....|....*....|....*....|....*
gi 15235794 428 AFKAKQGLQGFLIGLFVGISLCLSILLIFIARIDW 462
Cdd:cd13137 397 GFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKW 431
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
35-462 |
4.90e-21 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 95.29 E-value: 4.90e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 35 MRIGLPLVVMNLLWFGKMTTTSVFLGRQGELNLAGgSLGFSFANVTGFSVLYGISAAMEPICGQAFGAKNFKLLHKTLFM 114
Cdd:cd13133 8 LKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAA-SGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLWQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 115 AVLLLLLISVPISFL-WLNVHKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFTTAAATSL 193
Cdd:cd13133 87 GLYFSLLLAPLLALLsALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMVVV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 194 HIPINIVL------SKARGIEGVAMAVWITDFIVVILLTGYVIvvERMKENKWKQGGWLNQSAQDWLTLIKLSGPCCLTV 267
Cdd:cd13133 167 NIVLDYALifgklgFPAMGIAGAAIATVIAEAVSLLFFLLLLF--RRKNRRRFGLRRAWRFDRELLRRILRLGLPSGLQF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 268 CLEWWCYEILVLLTGRLPnpVQAVSILIIVFNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVGIISGC 347
Cdd:cd13133 245 FLDVGAFTVFFLLIGRLG--TTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYML 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 348 IGALVMIAFRGFWGSLYTHHDQ--LILNGVKKMMLIMAVIEVVNFPLMVCGEIVRGTAKPSLGMYANLSGFYLLALPLgA 425
Cdd:cd13133 323 LLGILFLLFPELLLSIFTPGADfaLIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPP-A 401
|
410 420 430
....*....|....*....|....*....|....*..
gi 15235794 426 TLAFKAKQGLQGFLIGLFVGISLCLSILLIFIARIDW 462
Cdd:cd13133 402 YLLVVLGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
36-442 |
1.06e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 79.08 E-value: 1.06e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 36 RIGLPLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFSFANVtGFSVLYGISAAMEPICGQAFGAKNFKLLHKTLFMA 115
Cdd:cd13134 7 ALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFL-LILIFSFISTGTSILIAQYLGAKDKKKARQIAGVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 116 VLLLLLISVPISFLWLNVHK-ILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFTTAAATSLH 194
Cdd:cd13134 86 LLFNLLLGLVFSLLLLFFGAeLLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 195 IPINIVL------SKARGIEGVAMAVWITDFIVVILLtgyVIVVERMKENKWKQGGWLNQSAQDWLTLIKLSGPccltVC 268
Cdd:cd13134 166 IVGNYLLifgwfgLPKLGVAGVAISTVISRAVGLVLL---FILLFRKLKIRFRLKDLRPFPKKLLKKILKIGLP----SA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 269 LEWWCYEILVLLTGRLPNP--VQAVSILIIVFNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVGIISG 346
Cdd:cd13134 239 GEELSYNLSQTVITAFIARlgTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVS 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 347 CIGALVMIAFRGFWGSLYThHDQLILNGVKKMMLIMAVIE---VVNfplMVCGEIVRGTAKPSLGMYANLSGFYLLALPL 423
Cdd:cd13134 319 LAVALLLALFREPILGLFT-DDPEIIALGKTLLLISILLEpgrAFN---IVLIGSLRAAGDARFPVLIGIISMWGISVPL 394
|
410
....*....|....*....
gi 15235794 424 GATLAFKAKQGLQGFLIGL 442
Cdd:cd13134 395 AYLLGIVLGLGLLGVWIAF 413
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
37-445 |
3.01e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 68.47 E-value: 3.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 37 IGLPLVVMNLLWFGKMTTTSVFLGRQGELNLAG-GSLGFSFANVTGFsvLYGISAAMEPICGQAFGAKNFKLLHKTLFMA 115
Cdd:cd13135 6 IAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAvGNVTTPFNTITGF--LGSISIGFTILGSQSVGAKDIKRINDYAISS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 116 VLLLLLISVPISFLW-LNVHKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFTTAAATSLH 194
Cdd:cd13135 84 IVYNSIIGVILFLLWlFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLLN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 195 IPINIVLSKAR------GIEGVAMAVWITDFIVVILLTgYVIVVERMKENKWKQGGWLNQSAQDWLTLIKLSGPccltVC 268
Cdd:cd13135 164 VILDYVLIFGNfgfprlGIIGAAIATTIANVLNLIILV-YLCRKIKKLTFKLSNTKVLKANIRPYKFTIKLGLP----LG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 269 LEWWCYEILVLLTGRLPNPVQ--AVSILIIVFNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVGIISG 346
Cdd:cd13135 239 GEEFLWNIGNLAVIRILNRIGelALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIY 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 347 CIGALVMIAFRGFWGSLYTHHDQLILNGVKKMMLImAVIEVVNFPLMVCGEIVRGTAKPSLGMYANLSGfYLLALPLGAT 426
Cdd:cd13135 319 IAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFI-IIILFFKSINIVYGFAIRAIGDTKWMLYTQIIG-TIIVVSVALL 396
|
410
....*....|....*....
gi 15235794 427 LAFKAKQGLQGFLIGLFVG 445
Cdd:cd13135 397 LIFVFKLGLAGVYITLFID 415
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
29-228 |
4.14e-11 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 64.78 E-value: 4.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 29 HELKLQMRIGLPLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFSFANVTgFSVLYGISAAMEPICGQAFGAKNFKLL 108
Cdd:COG0534 226 KILKRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLA-FMPALGLGQAAQPLVGQNLGAGDYDRA 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 109 HKTLFMAVLLLLLISVPIS-FLWLNVHKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFTT 187
Cdd:COG0534 305 RRAARLALLLALGIGLLLAlLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIIS 384
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 15235794 188 AAATSLH-IPINIVLSKAR-GIEGVAMAVWITDFIVVILLTGY 228
Cdd:COG0534 385 LLRLWLVrLPLAYLLAFLGlGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
296-463 |
6.18e-08 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 54.77 E-value: 6.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 296 IVFNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVGIISGCIGALVMIAFRGFWGSLYTHHDQLILNGV 375
Cdd:cd13138 265 IANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGA 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 376 kKMMLIMAVIEVVNFPLMVCGEIVRGTAKPSLGMYANLSGFYLLALPLGATLAFKAKQGLQGFLIGLFVGISLCLSILLI 455
Cdd:cd13138 345 -EYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICII 423
|
....*...
gi 15235794 456 FIARIDWE 463
Cdd:cd13138 424 YYRKGRWK 431
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
303-464 |
2.52e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 46.42 E-value: 2.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 303 LLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVGIISGCIGALVMIAFRGFWGSLYThHDQLILNGVKKMMLIM 382
Cdd:cd13142 284 LVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLILVIGGVLAFLFAEPIVRVFI-NDPEVIKEGADFLRIV 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 383 AVIEVVNFPLMVCGEIVRGTAKPSLGMYANLSGFYLLALPLGATLAFKAKQGLQGFLIGLFVGISLCLSILLIFIARIDW 462
Cdd:cd13142 363 APSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTW 442
|
..
gi 15235794 463 EK 464
Cdd:cd13142 443 KK 444
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
31-152 |
6.95e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 45.19 E-value: 6.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 31 LKLQMRIGLPLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFsfaNVTGFSVLY--GISAAMEPICGQAFGAKNFKLL 108
Cdd:cd13134 227 LKKILKIGLPSAGEELSYNLSQTVITAFIARLGTAALAARTYAS---NISMFVFLFslAIGQATQIIVGHLVGAGDFDEA 303
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 15235794 109 HKTLFMAVLLLLLISVPISFL-WLNVHKILTGFGQREDISFIAKK 152
Cdd:cd13134 304 YKRVLKSLKIGLLVSLAVALLlALFREPILGLFTDDPEIIALGKT 348
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
29-235 |
2.15e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 43.60 E-value: 2.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 29 HELKLQMRIGLPLVVMNLLW-FGKMTTTSvFLGRQGELNLAGGSLGFSFANVTgFSVLYGISAAMEPICGQAFGAKNFKL 107
Cdd:cd13138 222 EILKEILKIGLPSALQQSLVsISFLIINS-IVNSYGVVASAAYGIANKINSFA-FLPPSAIGQAVSTFVAQNIGAGKIER 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 108 LHKTLFMAVLLLLLISVPISFLWLNVHKILTG-FGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFT 186
Cdd:cd13138 300 AKKGLRTGIIISLIIGLIIILLVFFFAPQLLGlFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMII 379
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 15235794 187 TAAATSL-HIPINIVLSKAR--GIEGVAMAVWITDFIVVILLTGYVIVVERM 235
Cdd:cd13138 380 SILRLWLvRIPLAYLLSRLTglGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
82-230 |
4.24e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 42.50 E-value: 4.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 82 FSVLYGISAAMEPICGQAFGAKNFKLLHKTLFMAVLLLLLISVPI-SFLWLNVHKILTGFGQREDISFIAKKYLLYLLPE 160
Cdd:cd13143 276 FLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLfLILLLFPEQIVSLFTDDPELIALAARILRIFLLA 355
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15235794 161 LPILSFLCPLKAYLSSQGVTLPIMFTTAAATSL-HIPINIVLSKARGIEGVAMAVWITDFIVVILLTGYVI 230
Cdd:cd13143 356 FPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLfLIPLLLILPRLFGLDGIWLAFPLAEILTLLLALILLK 426
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
296-459 |
4.40e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 42.50 E-value: 4.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 296 IVFNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVGIISGCIGALVMIAFRG----FWGSlythhDQLI 371
Cdd:cd13143 45 LVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANRIFSTALLLSLILGLLLTILGLLFLDpllrLLGA-----SGEL 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 372 LNGVKKMMLIMAVIEVVNFPLMVCGEIVRGTAKPSLGMYANLSGFyLLALPLGATLAFKAKQGLQGFLIGLFVGISLCLS 451
Cdd:cd13143 120 LPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGA-VLNIILDPLFIFVLGLGIAGAALATVIAQLISLL 198
|
....*...
gi 15235794 452 ILLIFIAR 459
Cdd:cd13143 199 LLLLYFFR 206
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
29-240 |
5.63e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 42.13 E-value: 5.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 29 HELKLQMRIGLPLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFSFANVtGFSVLYGISAAMEPICGQAFGAKNFKLL 108
Cdd:cd13133 228 ELLRRILRLGLPSGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSL-AFLPMIGLGIAVSSLVGQALGAGRPDLA 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 109 HKTLFMAVLLLLLISVPIS-FLWLNVHKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAY---LSSQGVTLPIM 184
Cdd:cd13133 307 MRVTRRGLKLALAYMLLLGiLFLLFPELLLSIFTPGADFALIAELAVPLLRFVAAYILFDALALVFagaLRGAGDTRFVM 386
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 15235794 185 FTTAAATSLH-IPINIVLSKARGieGVAMAvWITDFIVVILLTgyVIVVERMKENKW 240
Cdd:cd13133 387 LAELIVAWLYlLPPAYLLVVLGA--GLAGA-WTVETVYVIVLA--LIFLLRFRSGKW 438
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
31-129 |
1.15e-03 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 41.08 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 31 LKLQMRIGLPLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFSFANVTgFSVLYGISAAMEPICGQAFGAKNFKLLHK 110
Cdd:TIGR00797 215 LKRLLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVESLL-FMPAFGFGIAVSILVGQALGAGDPKRAKE 293
|
90
....*....|....*....
gi 15235794 111 TLFMAVLLLLLISVPISFL 129
Cdd:TIGR00797 294 VARVALKLSLLLGLVLAII 312
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
23-456 |
1.71e-03 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 40.88 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 23 LMQSIVHELKLQMRIGLPLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLG-FSFANVTGFSVlyGISAAMEPICGQAFG 101
Cdd:PRK00187 1 MQVPPTTELKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGaASYSFVSIFCV--GVIAAVGTLVAIRHG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 102 AKNF----KLLHKTLFMAVLLLLLISVpisFLWlNVHKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSSQ 177
Cdd:PRK00187 79 AGDIegatRLAQAGLWLAWLLALVAAL---LLW-NLKPLLLLFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSAL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 178 GVTLPIMFTTAAATSLHIPINIVLSKAR------GIEGVAMAVWITDFIVVILLTGYVIVVERMKENKWKQGGWLNQSAQ 251
Cdd:PRK00187 155 GRAGPVMVISLAGAVANLLLNYALIEGWfglpklGLMGIGLVTALVSNGMALALALYIRRHPAYAAYPLRKGLSRPSRAA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 252 dWLTLIKLSGPCCLTVCLEWWCYEILVLLTGRLPNPVQA---VSILIIvfnfdYLLYAVMLSLGTCVATRVSNELGANNP 328
Cdd:PRK00187 235 -LRELWRLGLPIGGTYAVEVGLFTFAALCMGALGSTQLAahqIALQIV-----SVAFMVPVGLSYAVTMRVGQHYGAGRL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 329 KGAYRAAYttliVGIisGCiGALVMIAFRG-FW------GSLYTHHDQ----LILNGVKKMMLIMAVIEVVNFPLMVCGE 397
Cdd:PRK00187 309 LEARRAGR----VGI--GF-GAVVMLLFAGlFWllpeaiIGLFLDRNDpafaEIVQLAVSLLAVAAWFELFDGTQTIAMG 381
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 15235794 398 IVRGTAKPSLGMYANLSGFYLLALPLGATLAFKAKQGLQGFLIGLFVGISlCLSILLIF 456
Cdd:PRK00187 382 AIRGLKDARTTFLIGLACYWLVGAPLAWLLAFTLGWGAVGVWWGLALGLA-CAAVALTL 439
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
17-131 |
2.51e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 40.35 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 17 GLCSKTLMQSIVHELKLQMRIGLPLVVMNLLWFGKMTTTSVFLGRQGELNLAGGSLGFSFANVtGFSVLYGISAAMEPIC 96
Cdd:cd13135 213 KLSNTKVLKANIRPYKFTIKLGLPLGGEEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENI-VLMPMYGYSSAALTLV 291
|
90 100 110
....*....|....*....|....*....|....*
gi 15235794 97 GQAFGAKNFKLLHKTLFMAVLLLLLISVPISFLWL 131
Cdd:cd13135 292 GESIGKKDLKEALRIGNICLGLGLLIYIAAAIVFL 326
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
57-423 |
3.65e-03 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 39.80 E-value: 3.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 57 VFLGR-QGELNLAGGSLGFSFAN-VTGFSVLYGISAAmePICGQAFGAKNFKLLHKTLFMAVLLLLLISVPISFL-WLNV 133
Cdd:cd13143 29 IFVGHgVGALALAAVNLVFPIIMlLMALGLMIGVGGA--SLISRRLGAGDREKANRIFSTALLLSLILGLLLTILgLLFL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 134 HKILTGFGQREDISFIAKKYLLYLLPELPILSFLCPLKAYLSSQGVTLPIMFTTAAATSLHIPINIVLSKA--RGIEGVA 211
Cdd:cd13143 107 DPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAVLNIILDPLFIFVlgLGIAGAA 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 212 MAVWITDFIVVILLTGYVIVVERMKENKWKqggWLNQSAQDWLTLIKLSGP--------CCLTVCLEWwcyeILVLLTGr 283
Cdd:cd13143 187 LATVIAQLISLLLLLLYFFRGKSLLKLSLL---RFKLSLKIIKEILALGFPsflmqlssSVVTIVLNL----TLLGYGG- 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 284 lpnpVQAVSILIIVFNFDYLLYAVMLSLGTCVATRVSNELGANNPKGAYRAAYTTLIVGIISGCIGALVMIAFRGFWGSL 363
Cdd:cd13143 259 ----DIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFLILLLFPEQIVSL 334
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 364 YThHDQLILNGVKKMMLIMAVIEVVNFPLMVCGEIVRGTAKPSLGMYANLSGFYLLALPL 423
Cdd:cd13143 335 FT-DDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPL 393
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
303-471 |
7.76e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 38.75 E-value: 7.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 303 LLYAVMLSLGTC--VATRVSNELGANNPKGAYRAA-----YTTLIVGIISgcigaLVMIAFRGFWGSLYTHHDQLILNGV 375
Cdd:cd13139 284 IMFALLPAWGLSnaAATLVGQNLGAGQPDRAEKSVwragkYNMVFLGIVS-----LVFFLFAEPLVSFFTTDPEVIAIAV 358
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15235794 376 KKMMLI------MAVIEVVNFPLMVCGEIVRGTakpslgmYANLSGFYLLALPLGATLAFKAKQGLQGfliglfVGISLC 449
Cdd:cd13139 359 EALRIIslgyifYGYGMVLSQAFNGAGDTKTPT-------LINLVGFWLFQIPLAYLLARHLNLGPKG------VFIAIP 425
|
170 180
....*....|....*....|..
gi 15235794 450 LSILLIFIARIDWEKEAGKAQI 471
Cdd:cd13139 426 IAETVLAIAAIILFRRGKWKTV 447
|
|
| |
