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Conserved domains on  [gi|240256027|ref|NP_193880|]
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NAD(P)H dehydrogenase B3 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PTZ00318 super family cl33177
NADH dehydrogenase-like protein; Provisional
54-580 3.10e-129

NADH dehydrogenase-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00318:

Pssm-ID: 185553 [Multi-domain]  Cd Length: 424  Bit Score: 384.89  E-value: 3.10e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  54 RKRKVVLLGTGWAGASFLKTLNNSSYEVQVISPRNYFAFTPLLPSVTCGTVEARSVVEPIRNIARKQnvEMSFLEAECFK 133
Cdd:PTZ00318   9 KKPNVVVLGTGWAGAYFVRNLDPKKYNITVISPRNHMLFTPLLPQTTTGTLEFRSICEPVRPALAKL--PNRYLRAVVYD 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 134 IDPGSKKVYCRSKQGVNSKGKKEFDVDYDYLVIATGAQSNTFNIPGVEENCHFLKEVEDAQRIRSTVIDSFEKASLPGLN 213
Cdd:PTZ00318  87 VDFEEKRVKCGVVSKSNNANVNTFSVPYDKLVVAHGARPNTFNIPGVEERAFFLKEVNHARGIRKRIVQCIERASLPTTS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 214 EQERKRMLHFVVVGGGPTGVEFASELHDFVNEDLVKLYPKAKNLVQITLLEAADHILTMFDKRITEFAEEKFTRDGIDVK 293
Cdd:PTZ00318 167 VEERKRLLHFVVVGGGPTGVEFAAELADFFRDDVRNLNPELVEECKVTVLEAGSEVLGSFDQALRKYGQRRLRRLGVDIR 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 294 LGSMVVKVNDKEISakTKAGEVstIPYGMIVWSTGIGTRPVIKDFmkQIGQGNRRALATDEWLRVEGCDNIYALGDCATI 373
Cdd:PTZ00318 247 TKTAVKEVLDKEVV--LKDGEV--IPTGLVVWSTGVGPGPLTKQL--KVDKTSRGRISVDDHLRVKPIPNVFALGDCAAN 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 374 NQRKvmediaaifkkadkensgtltmkefhevmsdicdrypqvelylkskgmhgitdllkqaqaengsnksveldieelk 453
Cdd:PTZ00318 321 EERP---------------------------------------------------------------------------- 324
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 454 salcqvdsqvklLPATGQVAAQQGTYLAKCFDRMEvceknpegpirirgEGRHRFRPFRYRHLGQFAPLGGEQTAAQLpG 533
Cdd:PTZ00318 325 ------------LPTLAQVASQQGVYLAKEFNNEL--------------KGKPMSKPFVYRSLGSLAYLGNYSAIVQL-G 377
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 240256027 534 DWVSIGHSSQWLWYSVYASKQVSWRTRVLVVSDWMRRFIFGRDSSRI 580
Cdd:PTZ00318 378 AFDLSGFKALLFWRSAYLTILGSWRSKLYVLVNWAGTAIFGRDITRF 424
EFh super family cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
373-407 2.39e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


The actual alignment was detected with superfamily member cd00051:

Pssm-ID: 415501 [Multi-domain]  Cd Length: 63  Bit Score: 36.76  E-value: 2.39e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 240256027 373 INQRKVMEDIAAIFKKADKENSGTLTMKEFHEVMS 407
Cdd:cd00051   29 LGEGLSEEEIDEMIREVDKDGDGKIDFEEFLELMA 63
 
Name Accession Description Interval E-value
PTZ00318 PTZ00318
NADH dehydrogenase-like protein; Provisional
54-580 3.10e-129

NADH dehydrogenase-like protein; Provisional


Pssm-ID: 185553 [Multi-domain]  Cd Length: 424  Bit Score: 384.89  E-value: 3.10e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  54 RKRKVVLLGTGWAGASFLKTLNNSSYEVQVISPRNYFAFTPLLPSVTCGTVEARSVVEPIRNIARKQnvEMSFLEAECFK 133
Cdd:PTZ00318   9 KKPNVVVLGTGWAGAYFVRNLDPKKYNITVISPRNHMLFTPLLPQTTTGTLEFRSICEPVRPALAKL--PNRYLRAVVYD 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 134 IDPGSKKVYCRSKQGVNSKGKKEFDVDYDYLVIATGAQSNTFNIPGVEENCHFLKEVEDAQRIRSTVIDSFEKASLPGLN 213
Cdd:PTZ00318  87 VDFEEKRVKCGVVSKSNNANVNTFSVPYDKLVVAHGARPNTFNIPGVEERAFFLKEVNHARGIRKRIVQCIERASLPTTS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 214 EQERKRMLHFVVVGGGPTGVEFASELHDFVNEDLVKLYPKAKNLVQITLLEAADHILTMFDKRITEFAEEKFTRDGIDVK 293
Cdd:PTZ00318 167 VEERKRLLHFVVVGGGPTGVEFAAELADFFRDDVRNLNPELVEECKVTVLEAGSEVLGSFDQALRKYGQRRLRRLGVDIR 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 294 LGSMVVKVNDKEISakTKAGEVstIPYGMIVWSTGIGTRPVIKDFmkQIGQGNRRALATDEWLRVEGCDNIYALGDCATI 373
Cdd:PTZ00318 247 TKTAVKEVLDKEVV--LKDGEV--IPTGLVVWSTGVGPGPLTKQL--KVDKTSRGRISVDDHLRVKPIPNVFALGDCAAN 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 374 NQRKvmediaaifkkadkensgtltmkefhevmsdicdrypqvelylkskgmhgitdllkqaqaengsnksveldieelk 453
Cdd:PTZ00318 321 EERP---------------------------------------------------------------------------- 324
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 454 salcqvdsqvklLPATGQVAAQQGTYLAKCFDRMEvceknpegpirirgEGRHRFRPFRYRHLGQFAPLGGEQTAAQLpG 533
Cdd:PTZ00318 325 ------------LPTLAQVASQQGVYLAKEFNNEL--------------KGKPMSKPFVYRSLGSLAYLGNYSAIVQL-G 377
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 240256027 534 DWVSIGHSSQWLWYSVYASKQVSWRTRVLVVSDWMRRFIFGRDSSRI 580
Cdd:PTZ00318 378 AFDLSGFKALLFWRSAYLTILGSWRSKLYVLVNWAGTAIFGRDITRF 424
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
55-564 1.45e-77

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 250.43  E-value: 1.45e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  55 KRKVVLLGTGWAGASFLKTLNN---SSYEVQVISPRNYFAFTPLLPSVTCGTVEARSVVEPIRNIARKQNVEmsFLEAEC 131
Cdd:COG1252    1 MKRIVIVGGGFAGLEAARRLRKklgGDAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRRAGVR--FIQGEV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 132 FKIDPGSKKVYCRSKQgvnskgkkefDVDYDYLVIATGAQSNTFNIPGVEENCHFLKEVEDAQRIRSTVIDSFEKAslpg 211
Cdd:COG1252   79 TGIDPEARTVTLADGR----------TLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERA---- 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 212 lneqERKRMLHFvvvgggptgV---------EFASELHDFVNEdLVKLYPKAKNLVQITLLEAADHILTMFDKRITEFAE 282
Cdd:COG1252  145 ----ERRRLLTI---------VvvgggptgvELAGELAELLRK-LLRYPGIDPDKVRITLVEAGPRILPGLGEKLSEAAE 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 283 EKFTRDGIDVKLGSMVVKVNDKEIsaKTKAGEvsTIPYGMIVWSTGIGTRPVIKDFMKQIGQGNRraLATDEWLRVEGCD 362
Cdd:COG1252  211 KELEKRGVEVHTGTRVTEVDADGV--TLEDGE--EIPADTVIWAAGVKAPPLLADLGLPTDRRGR--VLVDPTLQVPGHP 284
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 363 NIYALGDCATInqrkvmediaaifkkadkensgtltmkefhevmsdicdrypqvelylkskgmhgitdllkqaqaengsn 442
Cdd:COG1252  285 NVFAIGDCAAV--------------------------------------------------------------------- 295
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 443 ksveldieelksalcqVDSQVKLLPATGQVAAQQGTYLAKCFDRmevceknpegpiRIRGEGRhrfRPFRYRHLGQFAPL 522
Cdd:COG1252  296 ----------------PDPDGKPVPKTAQAAVQQAKVLAKNIAA------------LLRGKPL---KPFRYRDKGCLASL 344
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 240256027 523 GGEQTAAQLPGDWVS--IGHssqWLWYSVYASKQVSWRTRVLVV 564
Cdd:COG1252  345 GRGAAVADVGGLKLSgfLAW---LLKRAIHLYFLPGFRGRLRVL 385
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
57-370 2.57e-54

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 186.37  E-value: 2.57e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027   57 KVVLLGTGWAGASFLKTLNNSSYEVQVIS-PRNYFAFTPLLPSVTCGTVEARS-------VVEPIRNIARKQNVEMSF-L 127
Cdd:pfam07992   2 DVVVIGGGPAGLAAALTLAQLGGKVTLIEdEGTCPYGGCVLSKALLGAAEAPEiaslwadLYKRKEEVVKKLNNGIEVlL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  128 EAECFKIDPGSKKVYCRskqgvNSKGKKEFDVDYDYLVIATGAQSNTFNIPGVEENCHFL-KEVEDAQRIRSTVIDsfEK 206
Cdd:pfam07992  82 GTEVVSIDPGAKKVVLE-----ELVDGDGETITYDRLVIATGARPRLPPIPGVELNVGFLvRTLDSAEALRLKLLP--KR 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  207 -----ASLPGLneqerkrmlhfvvvgggptgvEFASELHDFVnedlvklypkaknlVQITLLEAADHILTMFDKRITEFA 281
Cdd:pfam07992 155 vvvvgGGYIGV---------------------ELAAALAKLG--------------KEVTLIEALDRLLRAFDEEISAAL 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  282 EEKFTRDGIDVKLGSMVVKVNDKEISAKTKAGEVSTIPYGMIVWstGIGTRPVIkDFMKQIG--QGNRRALATDEWLRVE 359
Cdd:pfam07992 200 EKALEKNGVEVRLGTSVKEIIGDGDGVEVILKDGTEIDADLVVV--AIGRRPNT-ELLEAAGleLDERGGIVVDEYLRTS 276
                         330
                  ....*....|.
gi 240256027  360 gCDNIYALGDC 370
Cdd:pfam07992 277 -VPGIYAAGDC 286
lipoamide_DH TIGR01350
dihydrolipoamide dehydrogenase; This model describes dihydrolipoamide dehydrogenase, a ...
151-370 3.25e-11

dihydrolipoamide dehydrogenase; This model describes dihydrolipoamide dehydrogenase, a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system. This family includes a few members known to have distinct functions (ferric leghemoglobin reductase and NADH:ferredoxin oxidoreductase) but that may be predicted by homology to act as dihydrolipoamide dehydrogenase as well. The motif GGXCXXXGCXP near the N-terminus contains a redox-active disulfide.


Pssm-ID: 273568 [Multi-domain]  Cd Length: 460  Bit Score: 65.74  E-value: 3.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  151 SKGKKEFDVDYDYLVIATGAQSNTFNIPGVEEnchflkevedaqriRSTVIDSFEKASLPGLNEqerkrmlHFVVVGGGP 230
Cdd:TIGR01350 122 TGENGEETLEAKNIIIATGSRPRSLPGPFDFD--------------GKVVITSTGALNLEEVPE-------SLVIIGGGV 180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  231 TGVEFASELHDFVnedlvklypkaknlVQITLLEAADHILTMFDKRITEFAEEKFTRDGIDVKLGSMVVKV--NDKEISA 308
Cdd:TIGR01350 181 IGIEFASIFASLG--------------SKVTVIEMLDRILPGEDAEVSKVLQKALKKKGVKILTNTKVTAVekNDDQVTY 246
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 240256027  309 KTKAGEVSTIPYGMIVWStgIGTRPVIKDF-MKQIG--QGNRRALATDEWLRVeGCDNIYALGDC 370
Cdd:TIGR01350 247 ENKGGETETLTGEKVLVA--VGRKPNTEGLgLEKLGveLDERGRIVVDEYMRT-NVPGIYAIGDV 308
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
373-407 2.39e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 36.76  E-value: 2.39e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 240256027 373 INQRKVMEDIAAIFKKADKENSGTLTMKEFHEVMS 407
Cdd:cd00051   29 LGEGLSEEEIDEMIREVDKDGDGKIDFEEFLELMA 63
EF-hand_1 pfam00036
EF hand; The EF-hands can be divided into two classes: signalling proteins and buffering ...
381-409 6.60e-03

EF hand; The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.


Pssm-ID: 425435 [Multi-domain]  Cd Length: 29  Bit Score: 34.30  E-value: 6.60e-03
                          10        20
                  ....*....|....*....|....*....
gi 240256027  381 DIAAIFKKADKENSGTLTMKEFHEVMSDI 409
Cdd:pfam00036   1 ELKEIFRLFDKDGDGKIDFEEFKELLKKL 29
 
Name Accession Description Interval E-value
PTZ00318 PTZ00318
NADH dehydrogenase-like protein; Provisional
54-580 3.10e-129

NADH dehydrogenase-like protein; Provisional


Pssm-ID: 185553 [Multi-domain]  Cd Length: 424  Bit Score: 384.89  E-value: 3.10e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  54 RKRKVVLLGTGWAGASFLKTLNNSSYEVQVISPRNYFAFTPLLPSVTCGTVEARSVVEPIRNIARKQnvEMSFLEAECFK 133
Cdd:PTZ00318   9 KKPNVVVLGTGWAGAYFVRNLDPKKYNITVISPRNHMLFTPLLPQTTTGTLEFRSICEPVRPALAKL--PNRYLRAVVYD 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 134 IDPGSKKVYCRSKQGVNSKGKKEFDVDYDYLVIATGAQSNTFNIPGVEENCHFLKEVEDAQRIRSTVIDSFEKASLPGLN 213
Cdd:PTZ00318  87 VDFEEKRVKCGVVSKSNNANVNTFSVPYDKLVVAHGARPNTFNIPGVEERAFFLKEVNHARGIRKRIVQCIERASLPTTS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 214 EQERKRMLHFVVVGGGPTGVEFASELHDFVNEDLVKLYPKAKNLVQITLLEAADHILTMFDKRITEFAEEKFTRDGIDVK 293
Cdd:PTZ00318 167 VEERKRLLHFVVVGGGPTGVEFAAELADFFRDDVRNLNPELVEECKVTVLEAGSEVLGSFDQALRKYGQRRLRRLGVDIR 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 294 LGSMVVKVNDKEISakTKAGEVstIPYGMIVWSTGIGTRPVIKDFmkQIGQGNRRALATDEWLRVEGCDNIYALGDCATI 373
Cdd:PTZ00318 247 TKTAVKEVLDKEVV--LKDGEV--IPTGLVVWSTGVGPGPLTKQL--KVDKTSRGRISVDDHLRVKPIPNVFALGDCAAN 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 374 NQRKvmediaaifkkadkensgtltmkefhevmsdicdrypqvelylkskgmhgitdllkqaqaengsnksveldieelk 453
Cdd:PTZ00318 321 EERP---------------------------------------------------------------------------- 324
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 454 salcqvdsqvklLPATGQVAAQQGTYLAKCFDRMEvceknpegpirirgEGRHRFRPFRYRHLGQFAPLGGEQTAAQLpG 533
Cdd:PTZ00318 325 ------------LPTLAQVASQQGVYLAKEFNNEL--------------KGKPMSKPFVYRSLGSLAYLGNYSAIVQL-G 377
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 240256027 534 DWVSIGHSSQWLWYSVYASKQVSWRTRVLVVSDWMRRFIFGRDSSRI 580
Cdd:PTZ00318 378 AFDLSGFKALLFWRSAYLTILGSWRSKLYVLVNWAGTAIFGRDITRF 424
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
55-564 1.45e-77

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 250.43  E-value: 1.45e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  55 KRKVVLLGTGWAGASFLKTLNN---SSYEVQVISPRNYFAFTPLLPSVTCGTVEARSVVEPIRNIARKQNVEmsFLEAEC 131
Cdd:COG1252    1 MKRIVIVGGGFAGLEAARRLRKklgGDAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRRAGVR--FIQGEV 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 132 FKIDPGSKKVYCRSKQgvnskgkkefDVDYDYLVIATGAQSNTFNIPGVEENCHFLKEVEDAQRIRSTVIDSFEKAslpg 211
Cdd:COG1252   79 TGIDPEARTVTLADGR----------TLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERA---- 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 212 lneqERKRMLHFvvvgggptgV---------EFASELHDFVNEdLVKLYPKAKNLVQITLLEAADHILTMFDKRITEFAE 282
Cdd:COG1252  145 ----ERRRLLTI---------VvvgggptgvELAGELAELLRK-LLRYPGIDPDKVRITLVEAGPRILPGLGEKLSEAAE 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 283 EKFTRDGIDVKLGSMVVKVNDKEIsaKTKAGEvsTIPYGMIVWSTGIGTRPVIKDFMKQIGQGNRraLATDEWLRVEGCD 362
Cdd:COG1252  211 KELEKRGVEVHTGTRVTEVDADGV--TLEDGE--EIPADTVIWAAGVKAPPLLADLGLPTDRRGR--VLVDPTLQVPGHP 284
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 363 NIYALGDCATInqrkvmediaaifkkadkensgtltmkefhevmsdicdrypqvelylkskgmhgitdllkqaqaengsn 442
Cdd:COG1252  285 NVFAIGDCAAV--------------------------------------------------------------------- 295
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 443 ksveldieelksalcqVDSQVKLLPATGQVAAQQGTYLAKCFDRmevceknpegpiRIRGEGRhrfRPFRYRHLGQFAPL 522
Cdd:COG1252  296 ----------------PDPDGKPVPKTAQAAVQQAKVLAKNIAA------------LLRGKPL---KPFRYRDKGCLASL 344
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 240256027 523 GGEQTAAQLPGDWVS--IGHssqWLWYSVYASKQVSWRTRVLVV 564
Cdd:COG1252  345 GRGAAVADVGGLKLSgfLAW---LLKRAIHLYFLPGFRGRLRVL 385
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
57-370 2.57e-54

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 186.37  E-value: 2.57e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027   57 KVVLLGTGWAGASFLKTLNNSSYEVQVIS-PRNYFAFTPLLPSVTCGTVEARS-------VVEPIRNIARKQNVEMSF-L 127
Cdd:pfam07992   2 DVVVIGGGPAGLAAALTLAQLGGKVTLIEdEGTCPYGGCVLSKALLGAAEAPEiaslwadLYKRKEEVVKKLNNGIEVlL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  128 EAECFKIDPGSKKVYCRskqgvNSKGKKEFDVDYDYLVIATGAQSNTFNIPGVEENCHFL-KEVEDAQRIRSTVIDsfEK 206
Cdd:pfam07992  82 GTEVVSIDPGAKKVVLE-----ELVDGDGETITYDRLVIATGARPRLPPIPGVELNVGFLvRTLDSAEALRLKLLP--KR 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  207 -----ASLPGLneqerkrmlhfvvvgggptgvEFASELHDFVnedlvklypkaknlVQITLLEAADHILTMFDKRITEFA 281
Cdd:pfam07992 155 vvvvgGGYIGV---------------------ELAAALAKLG--------------KEVTLIEALDRLLRAFDEEISAAL 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  282 EEKFTRDGIDVKLGSMVVKVNDKEISAKTKAGEVSTIPYGMIVWstGIGTRPVIkDFMKQIG--QGNRRALATDEWLRVE 359
Cdd:pfam07992 200 EKALEKNGVEVRLGTSVKEIIGDGDGVEVILKDGTEIDADLVVV--AIGRRPNT-ELLEAAGleLDERGGIVVDEYLRTS 276
                         330
                  ....*....|.
gi 240256027  360 gCDNIYALGDC 370
Cdd:pfam07992 277 -VPGIYAAGDC 286
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
118-373 6.73e-30

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 119.92  E-value: 6.73e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 118 RKQNVEMsFLEAECFKIDPGSKKVYCRSKQgvnskgkkefDVDYDYLVIATGAQSNTFNIPGVE-ENCHFLKEVEDAQRI 196
Cdd:COG0446   47 ERKGIDV-RTGTEVTAIDPEAKTVTLRDGE----------TLSYDKLVLATGARPRPPPIPGLDlPGVFTLRTLDDADAL 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 197 RSTvidsfekaslpgLNEQERKR---------MLhfvvvgggptgvEFASELHdfvnedlvklypKAKnlVQITLLEAAD 267
Cdd:COG0446  116 REA------------LKEFKGKRavvigggpiGL------------ELAEALR------------KRG--LKVTLVERAP 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 268 HILTMFDKRITEFAEEKFTRDGIDVKLGSMVVKVN-DKEISAKTKAGEvsTIPYGMIVwsTGIGTRPVIkDFMKQIG--Q 344
Cdd:COG0446  158 RLLGVLDPEMAALLEEELREHGVELRLGETVVAIDgDDKVAVTLTDGE--EIPADLVV--VAPGVRPNT-ELAKDAGlaL 232
                        250       260
                 ....*....|....*....|....*....
gi 240256027 345 GNRRALATDEWLRVeGCDNIYALGDCATI 373
Cdd:COG0446  233 GERGWIKVDETLQT-SDPDVYAAGDCAEV 260
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
55-376 8.58e-25

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 106.76  E-value: 8.58e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  55 KRKVVLLGTGWAGASFLKTL--NNSSYEVQVISPRNYFAFT-PLLPSVTCGTVEARSVVEPIRNIARKQNVEMsFLEAEC 131
Cdd:COG1251    1 KMRIVIIGAGMAGVRAAEELrkLDPDGEITVIGAEPHPPYNrPPLSKVLAGETDEEDLLLRPADFYEENGIDL-RLGTRV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 132 FKIDPGSKKVYCRSKQgvnskgkkefDVDYDYLVIATGAQSNTFNIPGVE-ENCHFLKEVEDAQRIRS--------TVID 202
Cdd:COG1251   80 TAIDRAARTVTLADGE----------TLPYDKLVLATGSRPRVPPIPGADlPGVFTLRTLDDADALRAalapgkrvVVIG 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 203 sfekASLPGLneqerkrmlhfvvvgggptgvEFASELhdfvnedlvklypkAKNLVQITLLEAADHIL-TMFDKRITEFA 281
Cdd:COG1251  150 ----GGLIGL---------------------EAAAAL--------------RKRGLEVTVVERAPRLLpRQLDEEAGALL 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 282 EEKFTRDGIDVKLGSMVVKV--NDKEISAKTKAGEvsTIPYGMIVWSTGIgtRPVIkDFMKQ----IGQGnrraLATDEW 355
Cdd:COG1251  191 QRLLEALGVEVRLGTGVTEIegDDRVTGVRLADGE--ELPADLVVVAIGV--RPNT-ELARAaglaVDRG----IVVDDY 261
                        330       340
                 ....*....|....*....|.
gi 240256027 356 LRVeGCDNIYALGDCATINQR 376
Cdd:COG1251  262 LRT-SDPDIYAAGDCAEHPGP 281
PRK09564 PRK09564
coenzyme A disulfide reductase; Reviewed
57-376 6.94e-20

coenzyme A disulfide reductase; Reviewed


Pssm-ID: 181958 [Multi-domain]  Cd Length: 444  Bit Score: 92.41  E-value: 6.94e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  57 KVVLLGTGWAGASFLKTL--NNSSYEVQVISPRNYFAFTPL-LPSVTCGTVEarsvvEPIRNIAR------KQNVEMsFL 127
Cdd:PRK09564   2 KIIIIGGTAAGMSAAAKAkrLNKELEITVYEKTDIVSFGACgLPYFVGGFFD-----DPNTMIARtpeefiKSGIDV-KT 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 128 EAECFKIDPGSKKVYCRskqgvNSKGKKEFDVDYDYLVIATGAQSNTFNIPGVE-ENCHFLKEVEDAQRIRSTVIDSFEK 206
Cdd:PRK09564  76 EHEVVKVDAKNKTITVK-----NLKTGSIFNDTYDKLMIATGARPIIPPIKNINlENVYTLKSMEDGLALKELLKDEEIK 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 207 ------ASLPGLneqerkrmlhfvvvgggptgvEFASELHDfvnedlvklypKAKNlvqITLLEAADHILT-MFDKRITE 279
Cdd:PRK09564 151 niviigAGFIGL---------------------EAVEAAKH-----------LGKN---VRIIQLEDRILPdSFDKEITD 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 280 FAEEKFTRDGIDVKLGSMVVKV--NDKEISAKTKAGEVSTipyGMIVWSTGIgtRP---VIKD-FMKQIGQGnrrALATD 353
Cdd:PRK09564 196 VMEEELRENGVELHLNEFVKSLigEDKVEGVVTDKGEYEA---DVVIVATGV--KPnteFLEDtGLKTLKNG---AIIVD 267
                        330       340
                 ....*....|....*....|...
gi 240256027 354 EWLRVEgCDNIYALGDCATINQR 376
Cdd:PRK09564 268 EYGETS-IENIYAAGDCATIYNI 289
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
162-371 3.29e-15

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 78.20  E-value: 3.29e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 162 DYLVIATGAQSNTFNIPGVEENchflkevedaqrirsTVIDS---FEKASLPglneqerKRM---------Lhfvvvggg 229
Cdd:COG1249  132 DHIVIATGSRPRVPPIPGLDEV---------------RVLTSdeaLELEELP-------KSLvvigggyigL-------- 181
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 230 ptgvEFASELHDFVnedlvklypkaknlVQITLLEAADHILTMFDKRITEFAEEKFTRDGIDVKLGSMVVKV--NDKEIS 307
Cdd:COG1249  182 ----EFAQIFARLG--------------SEVTLVERGDRLLPGEDPEISEALEKALEKEGIDILTGAKVTSVekTGDGVT 243
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 240256027 308 AKTKAGE-VSTIPYGMIVWSTGIgtRPVIKDF-MKQIG--QGNRRALATDEWLRVeGCDNIYALGDCA 371
Cdd:COG1249  244 VTLEDGGgEEAVEADKVLVATGR--RPNTDGLgLEAAGveLDERGGIKVDEYLRT-SVPGIYAIGDVT 308
PRK06416 PRK06416
dihydrolipoamide dehydrogenase; Reviewed
258-369 2.20e-11

dihydrolipoamide dehydrogenase; Reviewed


Pssm-ID: 235798 [Multi-domain]  Cd Length: 462  Bit Score: 66.32  E-value: 2.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 258 VQITLLEAADHILTMFDKRITEFAEEKFTRDGIDVKLGSMVVKV--NDKEISAKT-KAGEVSTIPYGMIVWSTGIgtRPV 334
Cdd:PRK06416 196 AEVTIVEALPRILPGEDKEISKLAERALKKRGIKIKTGAKAKKVeqTDDGVTVTLeDGGKEETLEADYVLVAVGR--RPN 273
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 240256027 335 IKDfmkqIG---QG---NRRALATDEWLRvEGCDNIYALGD 369
Cdd:PRK06416 274 TEN----LGleeLGvktDRGFIEVDEQLR-TNVPNIYAIGD 309
lipoamide_DH TIGR01350
dihydrolipoamide dehydrogenase; This model describes dihydrolipoamide dehydrogenase, a ...
151-370 3.25e-11

dihydrolipoamide dehydrogenase; This model describes dihydrolipoamide dehydrogenase, a flavoprotein that acts in a number of ways. It is the E3 component of dehydrogenase complexes for pyruvate, 2-oxoglutarate, 2-oxoisovalerate, and acetoin. It can also serve as the L protein of the glycine cleavage system. This family includes a few members known to have distinct functions (ferric leghemoglobin reductase and NADH:ferredoxin oxidoreductase) but that may be predicted by homology to act as dihydrolipoamide dehydrogenase as well. The motif GGXCXXXGCXP near the N-terminus contains a redox-active disulfide.


Pssm-ID: 273568 [Multi-domain]  Cd Length: 460  Bit Score: 65.74  E-value: 3.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  151 SKGKKEFDVDYDYLVIATGAQSNTFNIPGVEEnchflkevedaqriRSTVIDSFEKASLPGLNEqerkrmlHFVVVGGGP 230
Cdd:TIGR01350 122 TGENGEETLEAKNIIIATGSRPRSLPGPFDFD--------------GKVVITSTGALNLEEVPE-------SLVIIGGGV 180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  231 TGVEFASELHDFVnedlvklypkaknlVQITLLEAADHILTMFDKRITEFAEEKFTRDGIDVKLGSMVVKV--NDKEISA 308
Cdd:TIGR01350 181 IGIEFASIFASLG--------------SKVTVIEMLDRILPGEDAEVSKVLQKALKKKGVKILTNTKVTAVekNDDQVTY 246
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 240256027  309 KTKAGEVSTIPYGMIVWStgIGTRPVIKDF-MKQIG--QGNRRALATDEWLRVeGCDNIYALGDC 370
Cdd:TIGR01350 247 ENKGGETETLTGEKVLVA--VGRKPNTEGLgLEKLGveLDERGRIVVDEYMRT-NVPGIYAIGDV 308
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
162-370 2.52e-06

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 50.18  E-value: 2.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 162 DYLVIATGaqSNTFNIPGVEEnchflkeVEDAQRIRSTviDSFEKASLPglneqerKRMLHFVVVgggPTGVEFASELHd 241
Cdd:PRK06292 132 KNIVIATG--SRVPPIPGVWL-------ILGDRLLTSD--DAFELDKLP-------KSLAVIGGG---VIGLELGQALS- 189
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 242 fvnedlvklypkakNL-VQITLLEAADHILTMFDKRITEFAEEKFTRDgIDVKLGSMVVKV---NDKEISAKTKAGEVST 317
Cdd:PRK06292 190 --------------RLgVKVTVFERGDRILPLEDPEVSKQAQKILSKE-FKIKLGAKVTSVeksGDEKVEELEKGGKTET 254
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 240256027 318 IPYGMIVWSTGIgtRPVIKDF-MKQIGqgnrraLATDEWLRVE-------GCDNIYALGDC 370
Cdd:PRK06292 255 IEADYVLVATGR--RPNTDGLgLENTG------IELDERGRPVvdehtqtSVPGIYAAGDV 307
nitri_red_nirB TIGR02374
nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen ...
58-376 3.05e-06

nitrite reductase [NAD(P)H], large subunit; [Central intermediary metabolism, Nitrogen metabolism]


Pssm-ID: 162827 [Multi-domain]  Cd Length: 785  Bit Score: 50.21  E-value: 3.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027   58 VVLLGTGWAGASF---LKTLNNSSYEVQVISPRNYFAFTP-LLPSVTCGTVEARSVVEPIRNIARKQNVEMsFLEAECFK 133
Cdd:TIGR02374   1 LVLVGNGMAGHRCieeVLKLNRHMFEITIFGEEPHPNYNRiLLSSVLQGEADLDDITLNSKDWYEKHGITL-YTGETVIQ 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  134 IDPGSKKVycrskqgVNSKGKKEFdvdYDYLVIATGAQSNTFNIPGVE-ENCHFLKEVEDAQRIRSTViDSFEKASL--P 210
Cdd:TIGR02374  80 IDTDQKQV-------ITDAGRTLS---YDKLILATGSYPFILPIPGADkKGVYVFRTIEDLDAIMAMA-QRFKKAAVigG 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  211 GLNEQERKRMLhfvvvgggptgVEFASELHdfvnedLVKLYPKaknLVQITLLEAADHILtmfdkritefaEEKFTRDGI 290
Cdd:TIGR02374 149 GLLGLEAAVGL-----------QNLGMDVS------VIHHAPG---LMAKQLDQTAGRLL-----------QRELEQKGL 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  291 DVKLGSmvvkvNDKEISAKTKAGEV-----STIPYGMIVWSTGIgtRPVIKdFMKQIGQGNRRALATDEWLRVEGcDNIY 365
Cdd:TIGR02374 198 TFLLEK-----DTVEIVGATKADRIrfkdgSSLEADLIVMAAGI--RPNDE-LAVSAGIKVNRGIIVNDSMQTSD-PDIY 268
                         330
                  ....*....|.
gi 240256027  366 ALGDCATINQR 376
Cdd:TIGR02374 269 AVGECAEHNGR 279
PRK13512 PRK13512
coenzyme A disulfide reductase; Provisional
130-378 3.36e-06

coenzyme A disulfide reductase; Provisional


Pssm-ID: 184103 [Multi-domain]  Cd Length: 438  Bit Score: 49.78  E-value: 3.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 130 ECFKIDPGSKKVYCRskqgvNSKGKKEFDVDYDYLVIATGAQSNTfniPGVEENCHF-LKEVEDAQRirstvIDSFekas 208
Cdd:PRK13512  80 EVIAINDERQTVTVL-----NRKTNEQFEESYDKLILSPGASANS---LGFESDITFtLRNLEDTDA-----IDQF---- 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 209 lpgLNEQERKRMLHFVVVGGGPtgvefaselhdfvnEDLVKLYPKAknlVQITLLEAADHILTMFDKRITEFAEEKFTRD 288
Cdd:PRK13512 143 ---IKANQVDKALVVGAGYISL--------------EVLENLYERG---LHPTLIHRSDKINKLMDADMNQPILDELDKR 202
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 289 GIDVKLGSMVVKVNDKEISAKTkaGEVSTipYGMIVwsTGIGTRPVIKdFMKqigqGNRRALATDEWLRVE-----GCDN 363
Cdd:PRK13512 203 EIPYRLNEEIDAINGNEVTFKS--GKVEH--YDMII--EGVGTHPNSK-FIE----SSNIKLDDKGFIPVNdkfetNVPN 271
                        250
                 ....*....|....*
gi 240256027 364 IYALGDCATINQRKV 378
Cdd:PRK13512 272 IYAIGDIITSHYRHV 286
PRK06327 PRK06327
dihydrolipoamide dehydrogenase; Validated
258-371 4.47e-06

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235779 [Multi-domain]  Cd Length: 475  Bit Score: 49.54  E-value: 4.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 258 VQITLLEAADHILTMFDKRITEFAEEKFTRDGIDVKLGsmvVKVNDKEISAK-------TKAGEVSTIPYGMIVWStgIG 330
Cdd:PRK06327 207 AEVTILEALPAFLAAADEQVAKEAAKAFTKQGLDIHLG---VKIGEIKTGGKgvsvaytDADGEAQTLEVDKLIVS--IG 281
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 240256027 331 TRPVIKDfmkqIGQGN-------RRALATDEWLRVeGCDNIYALGDCA 371
Cdd:PRK06327 282 RVPNTDG----LGLEAvglkldeRGFIPVDDHCRT-NVPNVYAIGDVV 324
PRK07251 PRK07251
FAD-containing oxidoreductase;
162-369 8.22e-06

FAD-containing oxidoreductase;


Pssm-ID: 180907 [Multi-domain]  Cd Length: 438  Bit Score: 48.59  E-value: 8.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 162 DYLVIATGAQSNTFNIPGVEENCHFLKevedaqrirSTVIDSFEKasLPglneqerKRMlhfVVVGGGPTGVEFASelhd 241
Cdd:PRK07251 120 ETIVINTGAVSNVLPIPGLADSKHVYD---------STGIQSLET--LP-------ERL---GIIGGGNIGLEFAG---- 174
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 242 fvnedlvkLYPKAKNlvQITLLEAADHILTMFDKRITEFAEEKFTRDGIDVKLGSMVVKV-NDKEISAKTKAGEvsTIPY 320
Cdd:PRK07251 175 --------LYNKLGS--KVTVLDAASTILPREEPSVAALAKQYMEEDGITFLLNAHTTEVkNDGDQVLVVTEDE--TYRF 242
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 240256027 321 GMIVWSTgiGTRPVIKDFMKQ---IGQGNRRALATDEWLR--VEGcdnIYALGD 369
Cdd:PRK07251 243 DALLYAT--GRKPNTEPLGLEntdIELTERGAIKVDDYCQtsVPG---VFAVGD 291
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
234-313 2.02e-05

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 42.96  E-value: 2.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  234 EFASELHDFVnedlvklypkaknlVQITLLEAADHILTMFDKRITEFAEEKFTRDGIDVKLGSMVVKV--NDKEISAKTK 311
Cdd:pfam00070  13 ELAGALARLG--------------SKVTVVERRDRLLPGFDPEIAKILQEKLEKNGIEFLLNTTVEAIegNGDGVVVVLT 78

                  ..
gi 240256027  312 AG 313
Cdd:pfam00070  79 DG 80
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
259-379 7.90e-05

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 45.29  E-value: 7.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 259 QITLLEAADHIL-TMFDKRITEFAEEKFTRDGIDVKLGSMVVKVN--DKEISAKTKAGEVSTIPygmIVWStGIGTRPVI 335
Cdd:PRK04965 166 AVTLVDNAASLLaSLMPPEVSSRLQHRLTEMGVHLLLKSQLQGLEktDSGIRATLDSGRSIEVD---AVIA-AAGLRPNT 241
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 240256027 336 KdFMKQIGQGNRRALATDEWLRVEGcDNIYALGDCATINQrKVM 379
Cdd:PRK04965 242 A-LARRAGLAVNRGIVVDSYLQTSA-PDIYALGDCAEING-QVL 282
PRK08010 PRK08010
pyridine nucleotide-disulfide oxidoreductase; Provisional
55-369 1.82e-04

pyridine nucleotide-disulfide oxidoreductase; Provisional


Pssm-ID: 181196 [Multi-domain]  Cd Length: 441  Bit Score: 44.23  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027  55 KRKVVLLGTGWAGASFLKTLNNSSYEVQVISPRN-YFAFTpllpSVTCGTVEARSVVEP-------IRNIARKQNVeMSF 126
Cdd:PRK08010   3 KYQAVIIGFGKAGKTLAVTLAKAGWRVALIEQSNaMYGGT----CINIGCIPTKTLVHDaqqhtdfVRAIQRKNEV-VNF 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 127 LEAECFK-----------------IDPGSKKVYcRSKQGVNSKGKKEFdvdydylvIATGAQSNTFNIPGVeenchflke 189
Cdd:PRK08010  78 LRNKNFHnladmpnidvidgqaefINNHSLRVH-RPEGNLEIHGEKIF--------INTGAQTVVPPIPGI--------- 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 190 vedaqrirSTVIDSFEKASLPGLNEqerkRMLHFVVVGGGPTGVEFASELHDFVNedlvklypkaknlvQITLLEAADHI 269
Cdd:PRK08010 140 --------TTTPGVYDSTGLLNLKE----LPGHLGILGGGYIGVEFASMFANFGS--------------KVTILEAASLF 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 270 LTMFDKRITEFAEEKFTRDGIDVKLGSMVVKVNDKEISAKTKAGEVSTIPYGMIVWStgiGTRPVIKDFMKQ---IGQGN 346
Cdd:PRK08010 194 LPREDRDIADNIATILRDQGVDIILNAHVERISHHENQVQVHSEHAQLAVDALLIAS---GRQPATASLHPEnagIAVNE 270
                        330       340
                 ....*....|....*....|...
gi 240256027 347 RRALATDEWLRVEGcDNIYALGD 369
Cdd:PRK08010 271 RGAIVVDKYLHTTA-DNIWAMGD 292
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
373-407 2.39e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 36.76  E-value: 2.39e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 240256027 373 INQRKVMEDIAAIFKKADKENSGTLTMKEFHEVMS 407
Cdd:cd00051   29 LGEGLSEEEIDEMIREVDKDGDGKIDFEEFLELMA 63
PRK06116 PRK06116
glutathione reductase; Validated
162-370 3.23e-03

glutathione reductase; Validated


Pssm-ID: 235701 [Multi-domain]  Cd Length: 450  Bit Score: 40.14  E-value: 3.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 162 DYLVIATGAQSNTFNIPGVEencHflkevedaqrirstVIDS---FEKASLPglneqerKRMLhfvVVGGGPTGVEFASE 238
Cdd:PRK06116 133 DHILIATGGRPSIPDIPGAE---Y--------------GITSdgfFALEELP-------KRVA---VVGAGYIAVEFAGV 185
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 240256027 239 LHdfvnedlvklypkakNL-VQITLLEAADHILTMFDKRITEFAEEKFTRDGIDVKLGSM---VVKVNDKEISAKTKAGE 314
Cdd:PRK06116 186 LN---------------GLgSETHLFVRGDAPLRGFDPDIRETLVEEMEKKGIRLHTNAVpkaVEKNADGSLTLTLEDGE 250
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 240256027 315 VSTIpyGMIVWStgIGTRPVIKDF-MKQIG--QGNRRALATDEWLR--VEGcdnIYALGDC 370
Cdd:PRK06116 251 TLTV--DCLIWA--IGREPNTDGLgLENAGvkLNEKGYIIVDEYQNtnVPG---IYAVGDV 304
EF-hand_1 pfam00036
EF hand; The EF-hands can be divided into two classes: signalling proteins and buffering ...
381-409 6.60e-03

EF hand; The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.


Pssm-ID: 425435 [Multi-domain]  Cd Length: 29  Bit Score: 34.30  E-value: 6.60e-03
                          10        20
                  ....*....|....*....|....*....
gi 240256027  381 DIAAIFKKADKENSGTLTMKEFHEVMSDI 409
Cdd:pfam00036   1 ELKEIFRLFDKDGDGKIDFEEFKELLKKL 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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