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Conserved domains on  [gi|145340426|ref|NP_193701|]
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NPR1-like protein 4 [Arabidopsis thaliana]

Protein Classification

BTB/POZ domain and ankyrin repeat-containing protein( domain architecture ID 13033777)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) and ANK (ankyrin repeat) domain-containing protein similar to Arabidopsis thaliana regulatory proteins, NPR3 and NPR4, which are involved in the regulation of basal defense responses against pathogens

Gene Ontology:  GO:0005515
PubMed:  17120193|27521773|17176038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NPR1_like_C pfam12313
NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. ...
 357-551 2.32e-101

NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. Proteins in this family are typically between 251 and 588 amino acids in length. The family is found in association with pfam00023, pfam00651. There are two conserved sequence motifs: LENRV and DLN. NPR1 (NIM1) is a defence protein in many plant species.


:

Pssm-ID: 372037  Cd Length: 204  Bit Score: 304.97  E-value: 2.32e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  357 RRLTRPKDYHTKTSR-KEPSKYRLCIDILEREIRRNPLVsGDTPTCSHSMPEDLQMRLLYLEKRVGLAQLFFPAEANVAM 435
Cdd:pfam12313   1 KRLTRAKDYNTSTEQgKESPKDRLCIEILEQEERRNPLP-GEASVSLAMAADDLRMRLLYLENRVALARLLFPAEAKVAM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  436 DVANVEGTSECTGLlTPPPSNDTTENLGKVDLNETPYVQTKRMLTRMKALMKTVETGRRYFPSCYEVLDKymdqYMDEEI 515
Cdd:pfam12313  80 DIAQVDGTSEFTGS-SSSPSKGTGGKRTAVDLNETPFKQKEEHLSRMRALSKTVELGKRFFPRCSEVLDK----FMDDDL 154

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 145340426  516 PDMSYPEKGTVKERRQKRMRYNELKNDVKKAYSKDK 551
Cdd:pfam12313 155 PDLAFLEKGTPEEQRQKRQRFMELQEDVQKAFSKDK 190
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 36-180 5.45e-73

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 229.50  E-value: 5.45e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  36 EELSSNLEQLLTNPDCDYTDAEIIIEEeANPVSVHRCVLAARSKFFLDLF-KKDKDSSEKKPKYQMKDLLPYGNVGREAF 114
Cdd:cd18310    1 KKLSSDLENLLDSPDLFYSDAEIIVEG-GRPVPVHRCILAARSPFFRDIFaSAKAEGANTKPKLELRELIPGGIVGYDAF 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145340426 115 LHFLSYIYTGRLKPFPIEVSTCVDSVCAHDSCKPAIDFAVELMYASFVFQIPDLVSSFQRKLRNYV 180
Cdd:cd18310   80 MLVLSYLYSGRLRLVPKEGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQRRLLDFV 145
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
260-358 7.00e-12

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.52  E-value: 7.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426 260 ALDSDDVELVKLLLTE-SDITLDQANG---LHYAVAYSDPKVVTQVLDLDmADVNFRNSRGYTVLHIAAMRREPTIIIPL 335
Cdd:COG0666  127 AAYNGNLEIVKLLLEAgADVNAQDNDGntpLHLAAANGNLEIVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLL 205

                         90       100
                 ....*....|....*....|...
gi 145340426 336 IQKGANASDFTFDGRSAVNICRR 358
Cdd:COG0666  206 LEAGADVNAKDNDGKTALDLAAE 228
DUF3420 pfam11900
Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. ...
 215-258 3.62e-11

Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with pfam00023.


:

Pssm-ID: 314729  Cd Length: 47  Bit Score: 58.20  E-value: 3.62e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 145340426  215 DLDRFCIEKELPLEVLEKIKQLRVKSVN---IPEVEDKSIERTGKVL 258
Cdd:pfam11900   1 DLDNFCLEKELPPEVLAKIKELRLKSSLpslSPELDDLLEKRVRRIL 47
 
Name Accession Description Interval E-value
NPR1_like_C pfam12313
NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. ...
 357-551 2.32e-101

NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. Proteins in this family are typically between 251 and 588 amino acids in length. The family is found in association with pfam00023, pfam00651. There are two conserved sequence motifs: LENRV and DLN. NPR1 (NIM1) is a defence protein in many plant species.


Pssm-ID: 372037  Cd Length: 204  Bit Score: 304.97  E-value: 2.32e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  357 RRLTRPKDYHTKTSR-KEPSKYRLCIDILEREIRRNPLVsGDTPTCSHSMPEDLQMRLLYLEKRVGLAQLFFPAEANVAM 435
Cdd:pfam12313   1 KRLTRAKDYNTSTEQgKESPKDRLCIEILEQEERRNPLP-GEASVSLAMAADDLRMRLLYLENRVALARLLFPAEAKVAM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  436 DVANVEGTSECTGLlTPPPSNDTTENLGKVDLNETPYVQTKRMLTRMKALMKTVETGRRYFPSCYEVLDKymdqYMDEEI 515
Cdd:pfam12313  80 DIAQVDGTSEFTGS-SSSPSKGTGGKRTAVDLNETPFKQKEEHLSRMRALSKTVELGKRFFPRCSEVLDK----FMDDDL 154

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 145340426  516 PDMSYPEKGTVKERRQKRMRYNELKNDVKKAYSKDK 551
Cdd:pfam12313 155 PDLAFLEKGTPEEQRQKRQRFMELQEDVQKAFSKDK 190
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 36-180 5.45e-73

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 229.50  E-value: 5.45e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  36 EELSSNLEQLLTNPDCDYTDAEIIIEEeANPVSVHRCVLAARSKFFLDLF-KKDKDSSEKKPKYQMKDLLPYGNVGREAF 114
Cdd:cd18310    1 KKLSSDLENLLDSPDLFYSDAEIIVEG-GRPVPVHRCILAARSPFFRDIFaSAKAEGANTKPKLELRELIPGGIVGYDAF 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145340426 115 LHFLSYIYTGRLKPFPIEVSTCVDSVCAHDSCKPAIDFAVELMYASFVFQIPDLVSSFQRKLRNYV 180
Cdd:cd18310   80 MLVLSYLYSGRLRLVPKEGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQRRLLDFV 145
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
260-358 7.00e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.52  E-value: 7.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426 260 ALDSDDVELVKLLLTE-SDITLDQANG---LHYAVAYSDPKVVTQVLDLDmADVNFRNSRGYTVLHIAAMRREPTIIIPL 335
Cdd:COG0666  127 AAYNGNLEIVKLLLEAgADVNAQDNDGntpLHLAAANGNLEIVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLL 205

                         90       100
                 ....*....|....*....|...
gi 145340426 336 IQKGANASDFTFDGRSAVNICRR 358
Cdd:COG0666  206 LEAGADVNAKDNDGKTALDLAAE 228
DUF3420 pfam11900
Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. ...
 215-258 3.62e-11

Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with pfam00023.


Pssm-ID: 314729  Cd Length: 47  Bit Score: 58.20  E-value: 3.62e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 145340426  215 DLDRFCIEKELPLEVLEKIKQLRVKSVN---IPEVEDKSIERTGKVL 258
Cdd:pfam11900   1 DLDNFCLEKELPPEVLAKIKELRLKSSLpslSPELDDLLEKRVRRIL 47
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 55-179 8.10e-09

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 53.08  E-value: 8.10e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426    55 DAEIIIEEEanPVSVHRCVLAARSKFFLDLFkKDKDSSEKKPKYQMKDllpygnVGREAFLHFLSYIYTGRLKPFPIEVS 134
Cdd:smart00225   1 DVTLVVGGK--KFHAHKAVLAAHSPYFKALF-SSDFKESDKSEIYLDD------VSPEDFRALLNFLYTGKLDLPEENVE 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 145340426   135 tcvdsvcahdsckpaidfavELMYASFVFQIPDLVSSFQRKLRNY 179
Cdd:smart00225  72 --------------------ELLELADYLQIPGLVELCEEFLLKL 96
Ank_2 pfam12796
Ankyrin repeats (3 copies);
260-341 4.39e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.19  E-value: 4.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  260 ALDSDDVELVKLLLTE-SDITLDQANG---LHYAVAYSDPKVVtQVLdLDMADVNFRNSrGYTVLHIAAMRREPTIIIPL 335
Cdd:pfam12796   4 AAKNGNLELVKLLLENgADANLQDKNGrtaLHLAAKNGHLEIV-KLL-LEHADVNLKDN-GRTALHYAARSGHLEIVKLL 80


                  ....*.
gi 145340426  336 IQKGAN 341
Cdd:pfam12796  81 LEKGAD 86
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 232-377 8.96e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.12  E-value: 8.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426 232 KIKQLRVKSVNIPEVEDKSIERTGKVLKALDSDDVEL-----VKLLLT-ESDITLDQANG---LHYAVAYSDPKVVTQVL 302
Cdd:PHA03100 133 NVNIKNSDGENLLHLYLESNKIDLKILKLLIDKGVDInaknrVNYLLSyGVPINIKDVYGftpLHYAVYNNNPEFVKYLL 212

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145340426 303 DLDmADVNFRNSRGYTVLHIAAMRREPTIIIPLIQKGANAsdftfdgrSAVNICRRLTRPKDYHTKTSRKEPSKY 377
Cdd:PHA03100 213 DLG-ANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSI--------KTIIETLLYFKDKDLNTITKIKMLKKS 278
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 42-128 3.50e-05

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 43.01  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426   42 LEQLLTNPDcdYTDAEIIIEEEanPVSVHRCVLAARSKFFLDLFKKDKDSSEkkpkyqmKDLLPYGNVGREAFLHFLSYI 121
Cdd:pfam00651   1 LNELREQGE--LCDVTLVVGDK--EFRAHKAVLAACSPYFKALFSGQESESS-------VSEITLDDVSPEDFEALLEFM 69


                  ....*..
gi 145340426  122 YTGRLKP 128
Cdd:pfam00651  70 YTGKLIS 76
 
Name Accession Description Interval E-value
NPR1_like_C pfam12313
NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. ...
 357-551 2.32e-101

NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. Proteins in this family are typically between 251 and 588 amino acids in length. The family is found in association with pfam00023, pfam00651. There are two conserved sequence motifs: LENRV and DLN. NPR1 (NIM1) is a defence protein in many plant species.


Pssm-ID: 372037  Cd Length: 204  Bit Score: 304.97  E-value: 2.32e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  357 RRLTRPKDYHTKTSR-KEPSKYRLCIDILEREIRRNPLVsGDTPTCSHSMPEDLQMRLLYLEKRVGLAQLFFPAEANVAM 435
Cdd:pfam12313   1 KRLTRAKDYNTSTEQgKESPKDRLCIEILEQEERRNPLP-GEASVSLAMAADDLRMRLLYLENRVALARLLFPAEAKVAM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  436 DVANVEGTSECTGLlTPPPSNDTTENLGKVDLNETPYVQTKRMLTRMKALMKTVETGRRYFPSCYEVLDKymdqYMDEEI 515
Cdd:pfam12313  80 DIAQVDGTSEFTGS-SSSPSKGTGGKRTAVDLNETPFKQKEEHLSRMRALSKTVELGKRFFPRCSEVLDK----FMDDDL 154

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 145340426  516 PDMSYPEKGTVKERRQKRMRYNELKNDVKKAYSKDK 551
Cdd:pfam12313 155 PDLAFLEKGTPEEQRQKRQRFMELQEDVQKAFSKDK 190
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 36-180 5.45e-73

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 229.50  E-value: 5.45e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  36 EELSSNLEQLLTNPDCDYTDAEIIIEEeANPVSVHRCVLAARSKFFLDLF-KKDKDSSEKKPKYQMKDLLPYGNVGREAF 114
Cdd:cd18310    1 KKLSSDLENLLDSPDLFYSDAEIIVEG-GRPVPVHRCILAARSPFFRDIFaSAKAEGANTKPKLELRELIPGGIVGYDAF 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145340426 115 LHFLSYIYTGRLKPFPIEVSTCVDSVCAHDSCKPAIDFAVELMYASFVFQIPDLVSSFQRKLRNYV 180
Cdd:cd18310   80 MLVLSYLYSGRLRLVPKEGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQRRLLDFV 145
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
260-358 7.00e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.52  E-value: 7.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426 260 ALDSDDVELVKLLLTE-SDITLDQANG---LHYAVAYSDPKVVTQVLDLDmADVNFRNSRGYTVLHIAAMRREPTIIIPL 335
Cdd:COG0666  127 AAYNGNLEIVKLLLEAgADVNAQDNDGntpLHLAAANGNLEIVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLL 205

                         90       100
                 ....*....|....*....|...
gi 145340426 336 IQKGANASDFTFDGRSAVNICRR 358
Cdd:COG0666  206 LEAGADVNAKDNDGKTALDLAAE 228
DUF3420 pfam11900
Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. ...
 215-258 3.62e-11

Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with pfam00023.


Pssm-ID: 314729  Cd Length: 47  Bit Score: 58.20  E-value: 3.62e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 145340426  215 DLDRFCIEKELPLEVLEKIKQLRVKSVN---IPEVEDKSIERTGKVL 258
Cdd:pfam11900   1 DLDNFCLEKELPPEVLAKIKELRLKSSLpslSPELDDLLEKRVRRIL 47
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-127 1.27e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 54.87  E-value: 1.27e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145340426  53 YTDAEIIIEEEanPVSVHRCVLAARSKFFLDLFKKDKdssekkpKYQMKDLLPYGNVGREAFLHFLSYIYTGRLK 127
Cdd:cd18186    1 LCDVTLVVGGR--EFPAHRAVLAARSPYFRAMFSSGM-------KESSSSEIELDDVSPEAFEALLDYIYTGELE 66
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-127 1.80e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 55.71  E-value: 1.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  37 ELSSNLEQLLTNPDcdYTDAEIIIEEEANPVsvHRCVLAARSKFFLDLFkkdkdssekkpkYQ-MK----DLLPYGNVGR 111
Cdd:cd18287    8 FLSEDIGALFLNEE--YSDVTFVVEEKRFPA--HRVILAARSEYFRALL------------YGgMResqqSEIELKDTNA 71

                         90
                 ....*....|....*.
gi 145340426 112 EAFLHFLSYIYTGRLK 127
Cdd:cd18287   72 EAFKALLKYIYTGRLT 87
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 55-179 8.10e-09

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 53.08  E-value: 8.10e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426    55 DAEIIIEEEanPVSVHRCVLAARSKFFLDLFkKDKDSSEKKPKYQMKDllpygnVGREAFLHFLSYIYTGRLKPFPIEVS 134
Cdd:smart00225   1 DVTLVVGGK--KFHAHKAVLAAHSPYFKALF-SSDFKESDKSEIYLDD------VSPEDFRALLNFLYTGKLDLPEENVE 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 145340426   135 tcvdsvcahdsckpaidfavELMYASFVFQIPDLVSSFQRKLRNY 179
Cdd:smart00225  72 --------------------ELLELADYLQIPGLVELCEEFLLKL 96
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
227-352 2.05e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 55.73  E-value: 2.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426 227 LEVLEKIKQLRVKSVNIPEVEDKSIERTGKVLKALDSDDVELVKLLLTESDITLDQANG---LHYAVAYSDPKVVTQVLD 303
Cdd:COG0666   29 ALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGntlLHAAARNGDLEIVKLLLE 108

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 145340426 304 LDmADVNFRNSRGYTVLHIAAMRREPTIIIPLIQKGANASDFTFDGRSA 352
Cdd:COG0666  109 AG-ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-133 2.24e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 52.25  E-value: 2.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  38 LSSNLEQLLTNPDcdYTDAEIIIEEEANPVSVHRCVLAARSKFFLDLFKKDKDSSEKKPKYQMKDLLPygnvgrEAFLHF 117
Cdd:cd18294    1 FAADMKSLINNPE--FSDVKFLVGPERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVLSDIEP------EVFRAV 72

                         90
                 ....*....|....*.
gi 145340426 118 LSYIYTGRLKPFPIEV 133
Cdd:cd18294   73 LEFIYTNCVTLSNHTV 88
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
260-355 4.04e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.96  E-value: 4.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426 260 ALDSDDVELVKLLLtESDITLDQANG-----LHYAVAYSDPKVVTQVLDLDmADVNFRNSRGYTVLHIAAMRREPTIIIP 334
Cdd:COG0666  160 AAANGNLEIVKLLL-EAGADVNARDNdgetpLHLAAENGHLEIVKLLLEAG-ADVNAKDNDGKTALDLAAENGNLEIVKL 237

                         90       100
                 ....*....|....*....|.
gi 145340426 335 LIQKGANASDFTFDGRSAVNI 355
Cdd:COG0666  238 LLEAGADLNAKDKDGLTALLL 258
Ank_2 pfam12796
Ankyrin repeats (3 copies);
260-341 4.39e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.19  E-value: 4.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  260 ALDSDDVELVKLLLTE-SDITLDQANG---LHYAVAYSDPKVVtQVLdLDMADVNFRNSrGYTVLHIAAMRREPTIIIPL 335
Cdd:pfam12796   4 AAKNGNLELVKLLLENgADANLQDKNGrtaLHLAAKNGHLEIV-KLL-LEHADVNLKDN-GRTALHYAARSGHLEIVKLL 80


                  ....*.
gi 145340426  336 IQKGAN 341
Cdd:pfam12796  81 LEKGAD 86
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 40-126 4.95e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 45.28  E-value: 4.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  40 SNLEQLLTNPDCdyTDAEIIIEEEaNPVSVHRCVLAARSKFFLDLFKKDKDSsekkpkyQMKDLlpygnVGREAFLHFLS 119
Cdd:cd18299    1 EDLRNLLHSPSC--ADVVFILQGG-VRIFAHRIVLAAASSVFADLFLMMTVV-------TLDSD-----ITPEAFRRVLE 65


                 ....*..
gi 145340426 120 YIYTGRL 126
Cdd:cd18299   66 FLYTGVL 72
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 232-377 8.96e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.12  E-value: 8.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426 232 KIKQLRVKSVNIPEVEDKSIERTGKVLKALDSDDVEL-----VKLLLT-ESDITLDQANG---LHYAVAYSDPKVVTQVL 302
Cdd:PHA03100 133 NVNIKNSDGENLLHLYLESNKIDLKILKLLIDKGVDInaknrVNYLLSyGVPINIKDVYGftpLHYAVYNNNPEFVKYLL 212

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145340426 303 DLDmADVNFRNSRGYTVLHIAAMRREPTIIIPLIQKGANAsdftfdgrSAVNICRRLTRPKDYHTKTSRKEPSKY 377
Cdd:PHA03100 213 DLG-ANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSI--------KTIIETLLYFKDKDLNTITKIKMLKKS 278
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 53-126 2.05e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 44.16  E-value: 2.05e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 145340426  53 YTDAEIIIEEEanPVSVHRCVLAARSKFFLDLFKKdkdssekkpKYQMKDLLPYGN--VGREAFLHFLSYIYTGRL 126
Cdd:cd18295   19 YSDVTFNVHGE--SFPAHRCILSARSPYFAEMFET---------KWKDKREINLKHplVNPDAFRALLQYLYTGRL 83
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-126 3.05e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 43.87  E-value: 3.05e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145340426  53 YTDAEIIIEEEAnpVSVHRCVLAARSKFFLDLFKKDKDSSEKKPkyqmkdllpyGNVGREAFLHFLSYIYTGRL 126
Cdd:cd18290   27 YCDVSVVVKGHA--FKAHRAVLAASSSYFRDLFNSSRSAVVELP----------AAVQPQSFQQILSFCYTGRL 88
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 42-128 3.50e-05

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 43.01  E-value: 3.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426   42 LEQLLTNPDcdYTDAEIIIEEEanPVSVHRCVLAARSKFFLDLFKKDKDSSEkkpkyqmKDLLPYGNVGREAFLHFLSYI 121
Cdd:pfam00651   1 LNELREQGE--LCDVTLVVGDK--EFRAHKAVLAACSPYFKALFSGQESESS-------VSEITLDDVSPEDFEALLEFM 69


                  ....*..
gi 145340426  122 YTGRLKP 128
Cdd:pfam00651  70 YTGKLIS 76
Ank_2 pfam12796
Ankyrin repeats (3 copies);
286-352 8.23e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.64  E-value: 8.23e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145340426  286 LHYAVAYSDPKVVTQVLDLDmADVNFRNSRGYTVLHIAAMRREPTIIIPLIQKgaNASDFTFDGRSA 352
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLEH--ADVNLKDNGRTA 64
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-126 4.45e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 40.40  E-value: 4.45e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145340426  53 YTDAEIIIEeeANPVSVHRCVLAARSKFFLDLFKKDKDSSEKKPkyqmkdllpyGNVGREAFLHFLSYIYTGRL 126
Cdd:cd18289   29 YCDVSIVVK--GQAFKAHRAVLAASSLYFRDLFSGNSKSAFELP----------ATVPPACFQQILSFCYTGKL 90
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 52-169 5.43e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 40.08  E-value: 5.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  52 DYTDAEIIIEEEAnpVSVHRCVLAARSKFFLDLFKKDKdssekkpKYQMKDLLPYGNVGREAFLHFLSYIYTGRlkpfpI 131
Cdd:cd18256   19 EFCDVQLQVGMEL--FSVHRLVLAASSPYFAALFAGGM-------SESSKDVVQIHGVEPDIFHILLDFIYTGV-----V 84

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 145340426 132 EVSTcvdsvcahdsckpaiDFAVELMYASFVFQIPDLV 169
Cdd:cd18256   85 EVTV---------------SNVQELLVAADMLQLTEVV 107
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 38-124 8.25e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 38.81  E-value: 8.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  38 LSSNLEQLLTNPDCDYTDAEIIIEEEANPVSVHRCVLAARSKFFLDLFKKDKDSSEKKPKyqmKDLLPYGNVGREAFLHF 117
Cdd:cd18301    1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAVG---CDVVHIEKVPPEIFEQL 77


                 ....*..
gi 145340426 118 LSYIYTG 124
Cdd:cd18301   78 LQFIYTD 84
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
256-352 8.60e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.48  E-value: 8.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426 256 KVLKALDSDDVELVKLLLTESDITLDQANGLHYAVAYSDPKVVTQVLDLDMADVNFRNSRGYTVLHIAAMRREPTIIIPL 335
Cdd:COG0666   27 AAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLL 106

                         90
                 ....*....|....*..
gi 145340426 336 IQKGANASDFTFDGRSA 352
Cdd:COG0666  107 LEAGADVNARDKDGETP 123
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-170 1.22e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 39.00  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  51 CDytdaeIIIEEEANPVSVHRCVLAARSKFFLDLFkkdkdsSEKKPKYQMKDLLPYGNVGREAFLHFLSYIYTGRLkpfp 130
Cdd:cd18293   16 CD-----VLLQAEGESVPAHCCVLSACSPYLTERL------SSEPPPAGQKVVLELQGLKAHTLLKLVDFLYTSEL---- 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 145340426 131 iEVSTcvdsvcahdsckpaiDFAVELMYASFVFQIPDLVS 170
Cdd:cd18293   81 -EVSS---------------EEAQDVLAAARRLQISELES 104
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 51-127 1.28e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 39.17  E-value: 1.28e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145340426  51 CDytdaeIIIEEEANPVSVHRCVLAARSKFFLDLFkKDKDSSEKKPKYQMKDLLPygnvgrEAFLHFLSYIYTGRLK 127
Cdd:cd18306   19 CD-----VILQVGGHEIPAHRAVLACASPYLFELF-SSDSDGESILTVKLDGLDP------DAVEVLVNYAYTSRLE 83
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 55-127 2.93e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 38.28  E-value: 2.93e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145340426  55 DAEIIIEEEANPVsvHRCVLAARSKFFLDLFkkdkdssekkpKYQMKDL----LPYGNVGREAFLHFLSYIYTGRLK 127
Cdd:cd18271   26 DFNIIVKDETIPC--HRCVLAACSDFFRAMF-----------EVNMKERddgsVTISNLSPKAVKAFLDYAYTGKAE 89
Ank_5 pfam13857
Ankyrin repeats (many copies);
302-356 5.56e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.40  E-value: 5.56e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 145340426  302 LDLDMADVNFRNSRGYTVLHIAAMRREPTIIIPLIQKGANASDFTFDGRSAVNIC 356
Cdd:pfam13857   2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 38-124 7.94e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 36.60  E-value: 7.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  38 LSSNLEQLLTNPDCDYTDAEIIIEEEanPVSVHRCVLAARSKFFLDLFkkdkdssekkpkyqmKDLLPYGNV-------- 109
Cdd:cd18309    5 LEQDMEAFLESVGGDFCDITLLLDGH--PIPAHKAILAARCSYFEAMF---------------RSFMPEDNTvnisigem 67

                         90
                 ....*....|....*..
gi 145340426 110 --GREAFLHFLSYIYTG 124
Cdd:cd18309   68 vpSRQAFDSLLRYIYYG 84
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-173 8.54e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 36.44  E-value: 8.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426  43 EQLLTNPDcdYTDAEIIIEEEANPVSVHRCVLAARSKFFLDLFKkdkdssekkpkyQMKDL----LPYGNVGREAFLHFL 118
Cdd:cd18231    6 EQRLFQPD--LCDVDIVLVRQRSTFPAHKGVLAAYSQFFHSLFT------------QNKQLqrveLSLEALTSQGLQQIL 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 145340426 119 SYIYTGRLkpfpievstCVDSVCAHDsckpaidfaveLMYASFVFQIPDLVSSFQ 173
Cdd:cd18231   72 NFIYTSKL---------LVNSCNVQD-----------VLNAAAVLQMNDIAASCQ 106
PHA03095 PHA03095
ankyrin-like protein; Provisional
 286-353 9.75e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.85  E-value: 9.75e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145340426 286 LHYAVAYSDPK--VVTQVLdLDMADVNFRNSRGYTVLHIAAMRREPTIIIPLIQKGANASDFTFDGRSAV 353
Cdd:PHA03095 226 LHSMATGSSCKrsLVLPLL-IAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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