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Conserved domains on  [gi|30684095|ref|NP_193491|]
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GATA transcription factor 26 [Arabidopsis thaliana]

Protein Classification

GATA-type transcription factor( domain architecture ID 10078952)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator; similar to Arabidopsis thaliana GATA transcription factor 26/27

Gene Ontology:  GO:0006355|GO:0008270|GO:0043565
PubMed:  31574210

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 6-51 1.38e-16

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 73.56  E-value: 1.38e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 30684095   6 PCYHCGVTNTPLWRNGPPEKPVLCNACGSRWRTKGTlvnYTPLHAR 51
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPSGGSTLCNACGLYWKKHGV---MRPLSKR 43
DEUBAD_NFRKB super family cl16477
DEUBAD domain found in nuclear factor related to kappa-B-binding protein (NFRKB) and similar ...
 269-369 1.18e-06

DEUBAD domain found in nuclear factor related to kappa-B-binding protein (NFRKB) and similar proteins; NFRKB, also called DNA-binding protein R kappa-B, or INO80 complex subunit G (INO80G), is a regulatory component of the metazoan INO80 complex involved in chromatin remodeling, transcription regulation, DNA replication and DNA repair. It modulates the deubiquitinase activity of UCHL5 in the INO80 complex. It binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. The model corresponds to the DEUBAD domain (conserved domain within the UCH regulatory proteins RPN13, NFRKB/INO80G, and ASX) of NFRKB, which binds primarily to the C-terminal ULD domain of UCH-L5.


The actual alignment was detected with superfamily member pfam13919:

Pssm-ID: 472945  Cd Length: 129  Bit Score: 47.67  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684095   269 KRTKSQTERV-HVLGSHGSPLCSIDLKDVFNfDEFIEQFTEEEQKKLMNLLPQ------IDSDDLPHSLRMMFESAQFKD 341
Cdd:pfam13919   4 KAQKKGKWEAeILLTSPKSPLVNADLRALLN-KAAWDCLPPEEQQELLSLLPDvdhildPDTDDSRPALPSLRNNEFFRH 82

                          90       100
                  ....*....|....*....|....*...
gi 30684095   342 NFSLFQQLIADGVFDVSSSSGAKLEEIR 369
Cdd:pfam13919  83 ACARFQEDLAEGRFDPELRQAWKAEEKR 110
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 6-51 1.38e-16

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 73.56  E-value: 1.38e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 30684095   6 PCYHCGVTNTPLWRNGPPEKPVLCNACGSRWRTKGTlvnYTPLHAR 51
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPSGGSTLCNACGLYWKKHGV---MRPLSKR 43
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 7-42 1.84e-15

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 70.04  E-value: 1.84e-15
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 30684095     7 CYHCGVTNTPLWRNGPPEKPVLCNACGSRWRTKGTL 42
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRTLCNACGLYYKKKGLK 36
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
6-54 1.35e-13

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 65.13  E-value: 1.35e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 30684095      6 PCYHCGVTNTPLWRNGPPEKPVLCNACGSRWRTKGTLVNytPLHARADG 54
Cdd:smart00401   5 SCSNCGTTETPLWRRGPSGNKTLCNACGLYYKKHGGLKR--PLSLKKDG 51
ASXH pfam13919
Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The ...
 269-369 1.18e-06

Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The LXXLL motif is detected in diverse transcription factors, coactivators and corepressors and is implicated in mediating interactions between them. The ASXH domain is found in animals, fungi and plants and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade of DUBs.


Pssm-ID: 464041  Cd Length: 129  Bit Score: 47.67  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684095   269 KRTKSQTERV-HVLGSHGSPLCSIDLKDVFNfDEFIEQFTEEEQKKLMNLLPQ------IDSDDLPHSLRMMFESAQFKD 341
Cdd:pfam13919   4 KAQKKGKWEAeILLTSPKSPLVNADLRALLN-KAAWDCLPPEEQQELLSLLPDvdhildPDTDDSRPALPSLRNNEFFRH 82

                          90       100
                  ....*....|....*....|....*...
gi 30684095   342 NFSLFQQLIADGVFDVSSSSGAKLEEIR 369
Cdd:pfam13919  83 ACARFQEDLAEGRFDPELRQAWKAEEKR 110
DEUBAD_NFRKB cd21865
DEUBAD domain found in nuclear factor related to kappa-B-binding protein (NFRKB) and similar ...
 292-355 3.84e-04

DEUBAD domain found in nuclear factor related to kappa-B-binding protein (NFRKB) and similar proteins; NFRKB, also called DNA-binding protein R kappa-B, or INO80 complex subunit G (INO80G), is a regulatory component of the metazoan INO80 complex involved in chromatin remodeling, transcription regulation, DNA replication and DNA repair. It modulates the deubiquitinase activity of UCHL5 in the INO80 complex. It binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. The model corresponds to the DEUBAD domain (conserved domain within the UCH regulatory proteins RPN13, NFRKB/INO80G, and ASX) of NFRKB, which binds primarily to the C-terminal ULD domain of UCH-L5.


Pssm-ID: 439381  Cd Length: 112  Bit Score: 39.88  E-value: 3.84e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30684095 292 DLKDVFNFDEFIEQFTEEEQKKLMNLLPQIDSDDLP---HSLRMMFESAQFK-DN-FSLFQQLIADGVF 355
Cdd:cd21865   7 IFKEVLSLETWNSLLSEEEREHLMQFLPQFPENDEEekeETLRMLFSGENFHfGNpLDKFQEKLKAGHF 75
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 6-51 1.38e-16

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 73.56  E-value: 1.38e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 30684095   6 PCYHCGVTNTPLWRNGPPEKPVLCNACGSRWRTKGTlvnYTPLHAR 51
Cdd:cd00202   1 ACSNCGTTTTPLWRRGPSGGSTLCNACGLYWKKHGV---MRPLSKR 43
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 7-42 1.84e-15

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 70.04  E-value: 1.84e-15
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 30684095     7 CYHCGVTNTPLWRNGPPEKPVLCNACGSRWRTKGTL 42
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRTLCNACGLYYKKKGLK 36
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
6-54 1.35e-13

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 65.13  E-value: 1.35e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 30684095      6 PCYHCGVTNTPLWRNGPPEKPVLCNACGSRWRTKGTLVNytPLHARADG 54
Cdd:smart00401   5 SCSNCGTTETPLWRRGPSGNKTLCNACGLYYKKHGGLKR--PLSLKKDG 51
ASXH pfam13919
Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The ...
 269-369 1.18e-06

Asx homology domain; A conserved alpha helical domain with a characteriztic LXXLL motif. The LXXLL motif is detected in diverse transcription factors, coactivators and corepressors and is implicated in mediating interactions between them. The ASXH domain is found in animals, fungi and plants and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade of DUBs.


Pssm-ID: 464041  Cd Length: 129  Bit Score: 47.67  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30684095   269 KRTKSQTERV-HVLGSHGSPLCSIDLKDVFNfDEFIEQFTEEEQKKLMNLLPQ------IDSDDLPHSLRMMFESAQFKD 341
Cdd:pfam13919   4 KAQKKGKWEAeILLTSPKSPLVNADLRALLN-KAAWDCLPPEEQQELLSLLPDvdhildPDTDDSRPALPSLRNNEFFRH 82

                          90       100
                  ....*....|....*....|....*...
gi 30684095   342 NFSLFQQLIADGVFDVSSSSGAKLEEIR 369
Cdd:pfam13919  83 ACARFQEDLAEGRFDPELRQAWKAEEKR 110
DEUBAD_NFRKB cd21865
DEUBAD domain found in nuclear factor related to kappa-B-binding protein (NFRKB) and similar ...
 292-355 3.84e-04

DEUBAD domain found in nuclear factor related to kappa-B-binding protein (NFRKB) and similar proteins; NFRKB, also called DNA-binding protein R kappa-B, or INO80 complex subunit G (INO80G), is a regulatory component of the metazoan INO80 complex involved in chromatin remodeling, transcription regulation, DNA replication and DNA repair. It modulates the deubiquitinase activity of UCHL5 in the INO80 complex. It binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'. The model corresponds to the DEUBAD domain (conserved domain within the UCH regulatory proteins RPN13, NFRKB/INO80G, and ASX) of NFRKB, which binds primarily to the C-terminal ULD domain of UCH-L5.


Pssm-ID: 439381  Cd Length: 112  Bit Score: 39.88  E-value: 3.84e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30684095 292 DLKDVFNFDEFIEQFTEEEQKKLMNLLPQIDSDDLP---HSLRMMFESAQFK-DN-FSLFQQLIADGVF 355
Cdd:cd21865   7 IFKEVLSLETWNSLLSEEEREHLMQFLPQFPENDEEekeETLRMLFSGENFHfGNpLDKFQEKLKAGHF 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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