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phenylalanine ammonia-lyase 2 [Arabidopsis thaliana]
Protein Classification
phenylalanine ammonia-lyase ( domain architecture ID 11476849 )
phenylalanine ammonia-lyase catalyzes the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton, i.e., the conversion of L-phenylalanine to trans-cinnamate and ammonia
List of domain hits
Name
Accession
Description
Interval
E-value
PLN02457
PLN02457 phenylalanine ammonia-lyase
13-717
0e+00
phenylalanine ammonia-lyase
Pssm-ID: 215251
Cd Length: 706
Bit Score: 1548.12
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 13 EKTKVAVTTKTL ADPLNWG L AA DQM KGSHLDEVK K MV E EYR R PVV N L G GETLTI G QVAA ISTV G - G S V K VEL A E TS RA G V 91
Cdd:PLN02457 2 GAASSEGFCIGG ADPLNWG K AA EAL KGSHLDEVK R MV A EYR K PVV K L E GETLTI A QVAA VARR G a G G V R VEL S E SA RA R V 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 92 KASSDWVMESM N KGTDSYGVTTGFGATSHRRTK N G T ALQ T ELIRFLNAGIFG NT k E TC HTLP Q SATRAAMLVR V NTLLQG 171
Cdd:PLN02457 82 KASSDWVMESM M KGTDSYGVTTGFGATSHRRTK Q G G ALQ R ELIRFLNAGIFG TG - E SG HTLP A SATRAAMLVR I NTLLQG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 172 YSGIRFEILEAIT S LLN H N IS P S LPLRGTITASGDLVPLSYIAGLLTGRPNSKA TG PDGE SL TA K EAF EK AGI ST GFF D L 251
Cdd:PLN02457 161 YSGIRFEILEAIT K LLN A N VT P C LPLRGTITASGDLVPLSYIAGLLTGRPNSKA VT PDGE KV TA A EAF KL AGI EG GFF E L 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 252 QPKEGLALVNGTAVGS GM AS M VLF E ANV Q AVLAEVLSA I F A EVM S GKPEFTDHLTH R LKHHPGQIEAAAIMEHILDGSSY 331
Cdd:PLN02457 241 QPKEGLALVNGTAVGS AL AS T VLF D ANV L AVLAEVLSA V F C EVM Q GKPEFTDHLTH K LKHHPGQIEAAAIMEHILDGSSY 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 332 MK L A Q K V HE M DPLQKPKQDRYALRTSPQWLGPQIEVIR Q ATKSIEREINSVNDNPLIDV S R N KA I HGGNFQGTPIGVSMD 411
Cdd:PLN02457 321 MK A A K K L HE T DPLQKPKQDRYALRTSPQWLGPQIEVIR A ATKSIEREINSVNDNPLIDV A R D KA L HGGNFQGTPIGVSMD 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 412 NTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNL TASS NPSLDYGFKGAEIAMASYCSELQYLANPVT S HVQSAEQHNQDV 491
Cdd:PLN02457 401 NTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNL SGGR NPSLDYGFKGAEIAMASYCSELQYLANPVT N HVQSAEQHNQDV 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 492 NSLGLIS S RKT S EAVDILKLMS T T F LV GI CQA V DLRHLEENL RQT VKNTVSQVAKK V LTTG I NGELHPSRFCEKDLLKVV 571
Cdd:PLN02457 481 NSLGLIS A RKT A EAVDILKLMS S T Y LV AL CQA I DLRHLEENL KSA VKNTVSQVAKK T LTTG A NGELHPSRFCEKDLLKVV 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 572 DRE Q VF T Y V DDPCSATYPLMQ R LRQV I V D HAL S NGE T EKNA V TS I F Q KIGAFEEELKA V LPKEVEAAR A AY G NGTAPIPN 651
Cdd:PLN02457 561 DRE P VF S Y I DDPCSATYPLMQ K LRQV L V E HAL A NGE A EKNA S TS V F R KIGAFEEELKA A LPKEVEAAR E AY E NGTAPIPN 640
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15231778 652 RIKECRSYPLYRFVREELGT K LLTGEK VV SPGEEFDKVF T A M C E GKLIDPL MD CLKEWNGAP I PIC 717
Cdd:PLN02457 641 RIKECRSYPLYRFVREELGT E LLTGEK TR SPGEEFDKVF D A I C Q GKLIDPL LE CLKEWNGAP L PIC 706
Name
Accession
Description
Interval
E-value
PLN02457
PLN02457 phenylalanine ammonia-lyase
13-717
0e+00
phenylalanine ammonia-lyase
Pssm-ID: 215251
Cd Length: 706
Bit Score: 1548.12
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 13 EKTKVAVTTKTL ADPLNWG L AA DQM KGSHLDEVK K MV E EYR R PVV N L G GETLTI G QVAA ISTV G - G S V K VEL A E TS RA G V 91
Cdd:PLN02457 2 GAASSEGFCIGG ADPLNWG K AA EAL KGSHLDEVK R MV A EYR K PVV K L E GETLTI A QVAA VARR G a G G V R VEL S E SA RA R V 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 92 KASSDWVMESM N KGTDSYGVTTGFGATSHRRTK N G T ALQ T ELIRFLNAGIFG NT k E TC HTLP Q SATRAAMLVR V NTLLQG 171
Cdd:PLN02457 82 KASSDWVMESM M KGTDSYGVTTGFGATSHRRTK Q G G ALQ R ELIRFLNAGIFG TG - E SG HTLP A SATRAAMLVR I NTLLQG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 172 YSGIRFEILEAIT S LLN H N IS P S LPLRGTITASGDLVPLSYIAGLLTGRPNSKA TG PDGE SL TA K EAF EK AGI ST GFF D L 251
Cdd:PLN02457 161 YSGIRFEILEAIT K LLN A N VT P C LPLRGTITASGDLVPLSYIAGLLTGRPNSKA VT PDGE KV TA A EAF KL AGI EG GFF E L 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 252 QPKEGLALVNGTAVGS GM AS M VLF E ANV Q AVLAEVLSA I F A EVM S GKPEFTDHLTH R LKHHPGQIEAAAIMEHILDGSSY 331
Cdd:PLN02457 241 QPKEGLALVNGTAVGS AL AS T VLF D ANV L AVLAEVLSA V F C EVM Q GKPEFTDHLTH K LKHHPGQIEAAAIMEHILDGSSY 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 332 MK L A Q K V HE M DPLQKPKQDRYALRTSPQWLGPQIEVIR Q ATKSIEREINSVNDNPLIDV S R N KA I HGGNFQGTPIGVSMD 411
Cdd:PLN02457 321 MK A A K K L HE T DPLQKPKQDRYALRTSPQWLGPQIEVIR A ATKSIEREINSVNDNPLIDV A R D KA L HGGNFQGTPIGVSMD 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 412 NTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNL TASS NPSLDYGFKGAEIAMASYCSELQYLANPVT S HVQSAEQHNQDV 491
Cdd:PLN02457 401 NTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNL SGGR NPSLDYGFKGAEIAMASYCSELQYLANPVT N HVQSAEQHNQDV 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 492 NSLGLIS S RKT S EAVDILKLMS T T F LV GI CQA V DLRHLEENL RQT VKNTVSQVAKK V LTTG I NGELHPSRFCEKDLLKVV 571
Cdd:PLN02457 481 NSLGLIS A RKT A EAVDILKLMS S T Y LV AL CQA I DLRHLEENL KSA VKNTVSQVAKK T LTTG A NGELHPSRFCEKDLLKVV 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 572 DRE Q VF T Y V DDPCSATYPLMQ R LRQV I V D HAL S NGE T EKNA V TS I F Q KIGAFEEELKA V LPKEVEAAR A AY G NGTAPIPN 651
Cdd:PLN02457 561 DRE P VF S Y I DDPCSATYPLMQ K LRQV L V E HAL A NGE A EKNA S TS V F R KIGAFEEELKA A LPKEVEAAR E AY E NGTAPIPN 640
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15231778 652 RIKECRSYPLYRFVREELGT K LLTGEK VV SPGEEFDKVF T A M C E GKLIDPL MD CLKEWNGAP I PIC 717
Cdd:PLN02457 641 RIKECRSYPLYRFVREELGT E LLTGEK TR SPGEEFDKVF D A I C Q GKLIDPL LE CLKEWNGAP L PIC 706
phe_am_lyase
TIGR01226 phenylalanine ammonia-lyase; Members of this subfamily of MIO prosthetic group enzymes are ...
26-707
0e+00
phenylalanine ammonia-lyase; Members of this subfamily of MIO prosthetic group enzymes are phenylalanine ammonia-lyases. They are found, so far, in plants and fungi. From phenylalanine, this enzyme yields cinnaminic acid, a precursor of many important plant compounds. This protein shows extensive homology to histidine ammonia-lyase, the first enzyme of a histidine degradation pathway. Note that members of this family from plant species that synthesize taxol are actually phenylalanine aminomutase, and are covered by exception model TIGR04473.
Pssm-ID: 130293 [Multi-domain]
Cd Length: 680
Bit Score: 1185.37
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 26 DPLNWG L AA DQ M K GS H LDEVK K MV E EYR - R P VVN L G G E TLTI G QVAA ISTV G gs V K VEL A E TS R - AG VKASS D WVM ES M N 103
Cdd:TIGR01226 1 DPLNWG T AA KT M A GS Q LDEVK R MV A EYR n G P LIK L D G A TLTI S QVAA AARR G -- V A VEL D E SA R v ER VKASS E WVM TQ M S 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 104 KGTD S YGVTTGFG A TSHRRTK N G T ALQ T EL I RFLNAGI F G NTKETCHT LP QS ATRAAMLVR V NTLLQGYSGIRFEILEAI 183
Cdd:TIGR01226 79 KGTD V YGVTTGFG G TSHRRTK Q G G ALQ K EL L RFLNAGI L G TGSDNHNS LP EE ATRAAMLVR I NTLLQGYSGIRFEILEAI 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 184 T S LLN H N IS P S LPLRGTITASGDLVPLSYIAGL L TGRPNSK ATG PDG ESLT A K EA FEK AGI S t G F F D LQPKEGLA L VNGT 263
Cdd:TIGR01226 159 T K LLN A N VT P C LPLRGTITASGDLVPLSYIAGL I TGRPNSK VYS PDG QIMS A A EA LKL AGI E - G G F E LQPKEGLA I VNGT 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 264 AVG SG MAS M VLFEAN VQ A V LAEVLSA I F A EVM S GKPEFTDHLTH R LKHHPGQIEAAAIMEHILDGSSY M K L A Q K VH EMDP 343
Cdd:TIGR01226 238 AVG AS MAS L VLFEAN IL A L LAEVLSA M F C EVM N GKPEFTDHLTH K LKHHPGQIEAAAIMEHILDGSSY A K H A E K EV EMDP 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 344 LQKPKQDRYALRTSPQWLGPQIEVIR Q ATK S IEREINSVNDNPLIDV S R N KA I HGGNFQGTPIGVSMDNTRLAIAAIGKL 423
Cdd:TIGR01226 318 LQKPKQDRYALRTSPQWLGPQIEVIR S ATK M IEREINSVNDNPLIDV E R G KA H HGGNFQGTPIGVSMDNTRLAIAAIGKL 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 424 MFAQFSELVNDFYNNGLPSNL TASS NPSLDYGFKGAEIAMASY C SELQ Y LANPVT S HVQSAEQHNQDVNSLGLIS S RKT S 503
Cdd:TIGR01226 398 MFAQFSELVNDFYNNGLPSNL AGGR NPSLDYGFKGAEIAMASY T SELQ F LANPVT N HVQSAEQHNQDVNSLGLIS A RKT A 477
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 504 EAVDILKLM ST T F L VGI CQAVDLRHLEEN LRQ TVKN T VS Q VAKKVL TT G IN GELHP S RFCEKDLLKV V DRE Q VF T Y V DDP 583
Cdd:TIGR01226 478 EAVDILKLM LA T Y L YAL CQAVDLRHLEEN FKS TVKN I VS E VAKKVL GM G LT GELHP K RFCEKDLLKV L DRE T VF D Y I DDP 557
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 584 CSA T YPLMQ R LRQV I V D HALSNGE T EK NA v T S I FQKI GA FE E ELKAVLP KE V EA ARAA YGN GT A P I PNRI K ECRSYPLYR 663
Cdd:TIGR01226 558 CSA N YPLMQ K LRQV L V E HALSNGE R EK DL - L S S FQKI QV FE A ELKAVLP PD V RG ARAA GDS GT S P A PNRI G ECRSYPLYR 636
650 660 670 680
....*....|....*....|....*....|....*....|....
gi 15231778 664 FVREELGTK L LTGEK VV SPGEE FD KV FT A MC EGK L IDPL MD CL K 707
Cdd:TIGR01226 637 FVREELGTK Y LTGEK YN SPGEE IS KV YE A IS EGK I IDPL LK CL D 680
Lyase_aromatic
pfam00221 Aromatic amino acid lyase; This family includes proteins with phenylalanine ammonia-lyase, EC: ...
64-533
0e+00
Aromatic amino acid lyase; This family includes proteins with phenylalanine ammonia-lyase, EC:4.3.1.24, histidine ammonia-lyase, EC:4.3.1.3, and tyrosine aminomutase, EC:5.4.3.6, activities.
Pssm-ID: 459718
Cd Length: 464
Bit Score: 563.20
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 64 LT IGQ V A A IST vg G SV KVEL AETS R AG V K AS SDWVM E SMNK G TDS YGV T TGFGA TSHR R T -- KNGTA LQ TE LIR FLN AG I 141
Cdd:pfam00221 1 LT LED V V A VAR -- G GA KVEL SPEA R ER V A AS RALLE E ILAE G RPV YGV N TGFGA LADV R I pp EDLEQ LQ RN LIR SHA AG V 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 142 F gntketc HT LP QSAT RA A ML V R V N T L LQ GYSG I R F E IL E AITS LLN HN I S P SL P L RG TIT ASGDL V PL SY IA GL L T G RP 221
Cdd:pfam00221 79 G ------- EP LP EEVV RA M ML L R L N S L AR GYSG V R P E VV E RLVA LLN AG I T P VV P E RG SVG ASGDL A PL AH IA LA L I G EG 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 222 NSKA tgp D GE SLT A K EA FEK AG IS tg FFD L Q PKEGLAL V NGTAV GSGM A SMV L FE A NVQAV LA E V LS A IFA E VMS G KPEF 301
Cdd:pfam00221 152 EVYY --- K GE RMP A A EA LAA AG LE -- PLE L G PKEGLAL I NGTAV MTAL A ALA L HD A ERLLR LA D V AA A LSL E ALR G SDDP 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 302 T D HLT H R L KH HPGQIE A AA IMEHI L D GS SYMK laqkvh EMDPLQKPK QD R Y A LR TS PQ WL G PQIEVIRQ A TKSI E R E I NS 381
Cdd:pfam00221 227 F D PRI H A L RP HPGQIE V AA NLRAL L A GS ELIR ------ SHPDCARLV QD P Y S LR CA PQ VH G AARDALAY A REVL E I E L NS 300
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 382 V N DNPL I D VSRNKAIH GGNF Q G T P IGVS MD NTRL A I A AI G K L MFAQFSE LVN DFY NNGLP SN L T A s SN P S L DY GF KG A EI 461
Cdd:pfam00221 301 V T DNPL V D FEDGEVLS GGNF H G Q P VALA MD FLAI A L A EL G N L SERRIAR LVN PAL NNGLP PF L A A - DD P G L NS GF MI A QY 379
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15231778 462 AM A SYC SE LQY LA N P VTSHVQSAEQHNQ D VN S L G L I SS RK TSEA V DI L KLMSTTF L VGIC QA V DLR HLEEN L 533
Cdd:pfam00221 380 TA A ALV SE NKV LA H P ASVDSIPTSAGQE D HV S M G T I AA RK LRQI V EN L ERVLAIE L LAAA QA L DLR RRPLK L 451
PAL-HAL
cd00332 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); PAL and HAL are members ...
62-527
0e+00
Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); PAL and HAL are members of the Lyase class I_like superfamily of enzymes that, catalyze similar beta-elimination reactions and are active as homotetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. PAL, present in plants and fungi, catalyzes the conversion of L-phenylalanine to E-cinnamic acid. HAL, found in several bacteria and animals, catalyzes the conversion of L-histidine to E-urocanic acid. Both PAL and HAL contain the cofactor 3, 5-dihydro-5-methylidene-4H-imidazol-4-one (MIO) which is formed by autocatalytic excision/cyclization of the internal tripeptide, Ala-Ser-Gly. PAL is being explored as enzyme substitution therapy for Phenylketonuria (PKU), a disorder which involves an inability to metabolize phenylalanine. HAL failure in humans results in the disease histidinemia.
Pssm-ID: 176460 [Multi-domain]
Cd Length: 444
Bit Score: 549.81
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 62 ET LT IGQ V A A IST vg G SV KVEL AETS R AG V K AS SDWVM E SMNK G TDS YGV T TGFGA TSHR R TKNG -- T ALQ TE L I R FLN A 139
Cdd:cd00332 1 GS LT LED V V A VAR -- G GE KVEL SPEA R ER V D AS RAALE E AAAE G KPV YGV N TGFGA LADV R IDDA dl R ALQ RN L L R SHA A 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 140 G IFG ntketch T LP QSAT RAAML V R V N T L LQ G Y SG I R F E I LE AITS LLN HNIS P SL P L RG TIT ASGDL V PL SY IA GL L T G 219
Cdd:cd00332 79 G VGP ------- P LP EEVV RAAML L R L N S L AR G H SG V R P E V LE RLVA LLN AGVT P VV P E RG SVG ASGDL A PL AH IA LA L I G 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 220 RPNSKA tgp D GE SLT A K EA FEK AG IST gf FD L QP KEGLAL V NGTAV GSGM A SMV L FE A NVQAV LA EVLS A IFA E VMS G KP 299
Cdd:cd00332 152 EGEVFY --- K GE RMP A A EA LAR AG LEP -- LE L GA KEGLAL I NGTAV MTAL A ALA L HD A ERLLD LA DIAG A LSL E ALR G SD 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 300 EFT D HLT H RLKH HPGQIE A AA IMEHI L D GSS YM klaqkvh E MDPLQKPK QD R Y A LR TS PQ WL G PQIEVI R Q A TKSI E R E I 379
Cdd:cd00332 227 APF D PRI H AARP HPGQIE V AA NLRAL L A GSS LW ------- E SHDGERRV QD P Y S LR CA PQ VH G AARDAL R Y A ARVL E I E L 299
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 380 NSV N DNPL I D VSRNKAIH GGNF Q G T P IGVS MD NTRL A I A AIGK L MFAQFSE LVN DFY n N GLP SN L T A ss N P S L DY GF KG A 459
Cdd:cd00332 300 NSV T DNPL V D PDNGEVLS GGNF H G Q P VALA MD FLAI A L A ELAN L SERRIAR LVN PAL - S GLP AF L V A -- D P G L NS GF MI A 376
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15231778 460 EIAM A SYCS E LQY LA N P VTSHVQSAEQHNQ D VN S L GLI SS RK TS E A VD I L KLMSTTF L VGIC QA V DLR 527
Cdd:cd00332 377 QYTA A ALVA E NKA LA H P ASVDSIPTSAGQE D HV S M GLI AA RK LR E I VD N L RRILAIE L LAAA QA L DLR 444
HutH
COG2986 Histidine ammonia-lyase [Amino acid transport and metabolism];
54-603
4.85e-135
Histidine ammonia-lyase [Amino acid transport and metabolism];
Pssm-ID: 442225
Cd Length: 503
Bit Score: 407.54
E-value: 4.85e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 54 RPV V N L G G ET LT IGQ V A A IST vg G SV KVEL AETS RA GVK AS SDW V M E SMNK G TDS YGV T TGFGA TSHR R -- TKNGTA LQ T 131
Cdd:COG2986 2 MTT V T L D G GS LT LED V V A VAR -- G GA KVEL SPEA RA RIE AS RAF V E E IAAE G KPV YGV N TGFGA LADV R ip PEDLEE LQ R 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 132 E LIR FLN AG I f G NT ketcht LP QSAT RA A ML V R V N T L LQ GYSG I R F E IL E AITS LLN HNIS P SL P LR G TIT ASGDL V PL S 211
Cdd:COG2986 80 N LIR SHA AG V - G EP ------ LP EEVV RA M ML L R L N S L AR GYSG V R P E VV E RLVA LLN AGVT P VV P EK G SVG ASGDL A PL A 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 212 YI A GL L T G R pnskat G P --- D GE SLT A K EA FEK AG IST gf FD L QP KEGLAL V NGT A V GSGM A SMV LF E A NVQAV LA E V LS 288
Cdd:COG2986 153 HL A LA L I G E ------ G E vfy K GE RMP A A EA LAE AG LEP -- LT L GA KEGLAL I NGT Q V MTAL A ALA LF D A ERLLD LA D V AA 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 289 A IFA E VMS G KPEFT D HLT H R L KH HPGQI EA AA IMEHI L D GS sym K L AQKVHEMDPL Q kpkq D R Y A LR TS PQ WL G PQIEVI 368
Cdd:COG2986 225 A LSL E ALL G SDAPF D PRI H A L RP HPGQI AV AA NLRAL L A GS --- E L VESHRNCRRV Q ---- D P Y S LR CA PQ VH G AVRDAL 297
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 369 RQ A TKSI E R E I NSV N DNPL IDVSRNKA I H GGNF Q G T P IGVS MD NTRL A I A AIGKLMFAQFSE LV NDFYNN GLP SN L TA ss 448
Cdd:COG2986 298 AY A REVL E I E L NSV T DNPL VFPDEGEV I S GGNF H G Q P VALA MD FLAI A L A ELANISERRIAR LV DPALSH GLP PF L VP -- 375
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 449 N P S L DY GF KG A EIAM A SYC SE LQY LA N P VTSHVQSAEQHNQ D VN S L G L I SS RK TSEA V DI L KLMSTTF L VGIC QA V DLR h 528
Cdd:COG2986 376 D P G L NS GF MI A QYTA A ALV SE NKT LA H P ASVDSIPTSANQE D HV S M G T I AA RK LRRI V EN L EQVLAIE L LAAA QA L DLR - 454
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15231778 529 leenlrqtvkntvsqvakkvlttgin G E L HP S RFC E K d LLKV V d RE Q V FTYVD D pc SATY P LMQRLRQV I VDH AL 603
Cdd:COG2986 455 -------------------------- G P L KL S PGT E A - AYAA V - RE V V PFLDE D -- RPLA P DIEAAAEL I RSG AL 499
Name
Accession
Description
Interval
E-value
PLN02457
PLN02457 phenylalanine ammonia-lyase
13-717
0e+00
phenylalanine ammonia-lyase
Pssm-ID: 215251
Cd Length: 706
Bit Score: 1548.12
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 13 EKTKVAVTTKTL ADPLNWG L AA DQM KGSHLDEVK K MV E EYR R PVV N L G GETLTI G QVAA ISTV G - G S V K VEL A E TS RA G V 91
Cdd:PLN02457 2 GAASSEGFCIGG ADPLNWG K AA EAL KGSHLDEVK R MV A EYR K PVV K L E GETLTI A QVAA VARR G a G G V R VEL S E SA RA R V 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 92 KASSDWVMESM N KGTDSYGVTTGFGATSHRRTK N G T ALQ T ELIRFLNAGIFG NT k E TC HTLP Q SATRAAMLVR V NTLLQG 171
Cdd:PLN02457 82 KASSDWVMESM M KGTDSYGVTTGFGATSHRRTK Q G G ALQ R ELIRFLNAGIFG TG - E SG HTLP A SATRAAMLVR I NTLLQG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 172 YSGIRFEILEAIT S LLN H N IS P S LPLRGTITASGDLVPLSYIAGLLTGRPNSKA TG PDGE SL TA K EAF EK AGI ST GFF D L 251
Cdd:PLN02457 161 YSGIRFEILEAIT K LLN A N VT P C LPLRGTITASGDLVPLSYIAGLLTGRPNSKA VT PDGE KV TA A EAF KL AGI EG GFF E L 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 252 QPKEGLALVNGTAVGS GM AS M VLF E ANV Q AVLAEVLSA I F A EVM S GKPEFTDHLTH R LKHHPGQIEAAAIMEHILDGSSY 331
Cdd:PLN02457 241 QPKEGLALVNGTAVGS AL AS T VLF D ANV L AVLAEVLSA V F C EVM Q GKPEFTDHLTH K LKHHPGQIEAAAIMEHILDGSSY 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 332 MK L A Q K V HE M DPLQKPKQDRYALRTSPQWLGPQIEVIR Q ATKSIEREINSVNDNPLIDV S R N KA I HGGNFQGTPIGVSMD 411
Cdd:PLN02457 321 MK A A K K L HE T DPLQKPKQDRYALRTSPQWLGPQIEVIR A ATKSIEREINSVNDNPLIDV A R D KA L HGGNFQGTPIGVSMD 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 412 NTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNL TASS NPSLDYGFKGAEIAMASYCSELQYLANPVT S HVQSAEQHNQDV 491
Cdd:PLN02457 401 NTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNL SGGR NPSLDYGFKGAEIAMASYCSELQYLANPVT N HVQSAEQHNQDV 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 492 NSLGLIS S RKT S EAVDILKLMS T T F LV GI CQA V DLRHLEENL RQT VKNTVSQVAKK V LTTG I NGELHPSRFCEKDLLKVV 571
Cdd:PLN02457 481 NSLGLIS A RKT A EAVDILKLMS S T Y LV AL CQA I DLRHLEENL KSA VKNTVSQVAKK T LTTG A NGELHPSRFCEKDLLKVV 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 572 DRE Q VF T Y V DDPCSATYPLMQ R LRQV I V D HAL S NGE T EKNA V TS I F Q KIGAFEEELKA V LPKEVEAAR A AY G NGTAPIPN 651
Cdd:PLN02457 561 DRE P VF S Y I DDPCSATYPLMQ K LRQV L V E HAL A NGE A EKNA S TS V F R KIGAFEEELKA A LPKEVEAAR E AY E NGTAPIPN 640
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15231778 652 RIKECRSYPLYRFVREELGT K LLTGEK VV SPGEEFDKVF T A M C E GKLIDPL MD CLKEWNGAP I PIC 717
Cdd:PLN02457 641 RIKECRSYPLYRFVREELGT E LLTGEK TR SPGEEFDKVF D A I C Q GKLIDPL LE CLKEWNGAP L PIC 706
phe_am_lyase
TIGR01226 phenylalanine ammonia-lyase; Members of this subfamily of MIO prosthetic group enzymes are ...
26-707
0e+00
phenylalanine ammonia-lyase; Members of this subfamily of MIO prosthetic group enzymes are phenylalanine ammonia-lyases. They are found, so far, in plants and fungi. From phenylalanine, this enzyme yields cinnaminic acid, a precursor of many important plant compounds. This protein shows extensive homology to histidine ammonia-lyase, the first enzyme of a histidine degradation pathway. Note that members of this family from plant species that synthesize taxol are actually phenylalanine aminomutase, and are covered by exception model TIGR04473.
Pssm-ID: 130293 [Multi-domain]
Cd Length: 680
Bit Score: 1185.37
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 26 DPLNWG L AA DQ M K GS H LDEVK K MV E EYR - R P VVN L G G E TLTI G QVAA ISTV G gs V K VEL A E TS R - AG VKASS D WVM ES M N 103
Cdd:TIGR01226 1 DPLNWG T AA KT M A GS Q LDEVK R MV A EYR n G P LIK L D G A TLTI S QVAA AARR G -- V A VEL D E SA R v ER VKASS E WVM TQ M S 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 104 KGTD S YGVTTGFG A TSHRRTK N G T ALQ T EL I RFLNAGI F G NTKETCHT LP QS ATRAAMLVR V NTLLQGYSGIRFEILEAI 183
Cdd:TIGR01226 79 KGTD V YGVTTGFG G TSHRRTK Q G G ALQ K EL L RFLNAGI L G TGSDNHNS LP EE ATRAAMLVR I NTLLQGYSGIRFEILEAI 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 184 T S LLN H N IS P S LPLRGTITASGDLVPLSYIAGL L TGRPNSK ATG PDG ESLT A K EA FEK AGI S t G F F D LQPKEGLA L VNGT 263
Cdd:TIGR01226 159 T K LLN A N VT P C LPLRGTITASGDLVPLSYIAGL I TGRPNSK VYS PDG QIMS A A EA LKL AGI E - G G F E LQPKEGLA I VNGT 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 264 AVG SG MAS M VLFEAN VQ A V LAEVLSA I F A EVM S GKPEFTDHLTH R LKHHPGQIEAAAIMEHILDGSSY M K L A Q K VH EMDP 343
Cdd:TIGR01226 238 AVG AS MAS L VLFEAN IL A L LAEVLSA M F C EVM N GKPEFTDHLTH K LKHHPGQIEAAAIMEHILDGSSY A K H A E K EV EMDP 317
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 344 LQKPKQDRYALRTSPQWLGPQIEVIR Q ATK S IEREINSVNDNPLIDV S R N KA I HGGNFQGTPIGVSMDNTRLAIAAIGKL 423
Cdd:TIGR01226 318 LQKPKQDRYALRTSPQWLGPQIEVIR S ATK M IEREINSVNDNPLIDV E R G KA H HGGNFQGTPIGVSMDNTRLAIAAIGKL 397
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 424 MFAQFSELVNDFYNNGLPSNL TASS NPSLDYGFKGAEIAMASY C SELQ Y LANPVT S HVQSAEQHNQDVNSLGLIS S RKT S 503
Cdd:TIGR01226 398 MFAQFSELVNDFYNNGLPSNL AGGR NPSLDYGFKGAEIAMASY T SELQ F LANPVT N HVQSAEQHNQDVNSLGLIS A RKT A 477
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 504 EAVDILKLM ST T F L VGI CQAVDLRHLEEN LRQ TVKN T VS Q VAKKVL TT G IN GELHP S RFCEKDLLKV V DRE Q VF T Y V DDP 583
Cdd:TIGR01226 478 EAVDILKLM LA T Y L YAL CQAVDLRHLEEN FKS TVKN I VS E VAKKVL GM G LT GELHP K RFCEKDLLKV L DRE T VF D Y I DDP 557
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 584 CSA T YPLMQ R LRQV I V D HALSNGE T EK NA v T S I FQKI GA FE E ELKAVLP KE V EA ARAA YGN GT A P I PNRI K ECRSYPLYR 663
Cdd:TIGR01226 558 CSA N YPLMQ K LRQV L V E HALSNGE R EK DL - L S S FQKI QV FE A ELKAVLP PD V RG ARAA GDS GT S P A PNRI G ECRSYPLYR 636
650 660 670 680
....*....|....*....|....*....|....*....|....
gi 15231778 664 FVREELGTK L LTGEK VV SPGEE FD KV FT A MC EGK L IDPL MD CL K 707
Cdd:TIGR01226 637 FVREELGTK Y LTGEK YN SPGEE IS KV YE A IS EGK I IDPL LK CL D 680
taxol_Phe_23mut
TIGR04473 phenylalanine aminomutase (L-beta-phenylalanine forming); Members of this family are the ...
42-713
0e+00
phenylalanine aminomutase (L-beta-phenylalanine forming); Members of this family are the phenylalanine aminomutase known from taxol biosynthesis. This enzyme has the MIO prosthetic group (4-methylideneimidazole-5-one), derived from an Ala-Ser-Gly motif. Other MIO enzymes include Phe, Tyr, and His ammonia-lyases. This model serves as an exception to overrule assignments by equivalog model TIGR01226 for phenylalanine ammonia-lyase.
Pssm-ID: 275266
Cd Length: 687
Bit Score: 590.15
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 42 LD EVKK MVEEYRR P V vnlggetl T IGQ VAA IST v GGS VKV E L - AE TS RA G V KAS S D WV MESMNK G T D S YGVTTGFGA T S H 120
Cdd:TIGR04473 21 FN EVKK ITVDGTT P I -------- T VAH VAA LAR - RHD VKV A L e AE QC RA R V ETC S S WV QRKAED G A D I YGVTTGFGA C S S 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 121 RRT KNGTA LQ TE LIR F L N AG I F GN - TKETCHT LP QS ATR A AML V R V N TLLQ G Y SGIR F E IL EA ITS LLN H N I SP SL PLRG 199
Cdd:TIGR04473 92 RRT NQLSE LQ ES LIR C L L AG V F TK g CASSVDE LP AT ATR S AML L R L N SFTY G C SGIR W E VM EA LEK LLN S N V SP KV PLRG 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 200 TIT ASGDL V PL S YIAGLL T G R P NSK A TGP D GESLT A K EA FEKA G IST gf F D LQ P KEGLALVNGT AVGSGM AS M V LFE ANV 279
Cdd:TIGR04473 172 SVS ASGDL I PL A YIAGLL I G K P SVI A RIG D DVEVP A P EA LSRV G LRP -- F K LQ A KEGLALVNGT SFATAL AS T V MYD ANV 249
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 280 QAV L A E V L SAI F A EV MS G KP EF TDH L T H RL K H HPGQIE A A AIM E HI L DG S SYMK L AQKVHEM D P L Q KPKQDRYALR T SPQ 359
Cdd:TIGR04473 250 LLL L V E T L CGM F C EV IF G RE EF AHP L I H KV K P HPGQIE S A ELL E WL L RS S PFQD L SREYYSI D K L K KPKQDRYALR S SPQ 329
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 360 WL G P QIEV IR Q AT KSI E R E I NS V NDNP L ID VSRNK A I HG G NFQG TPI G VS MD NT R L A I A AI GKL M FAQF S EL VNDF Y N NG 439
Cdd:TIGR04473 330 WL A P LVQT IR D AT TTV E T E V NS A NDNP I ID HANDR A L HG A NFQG SAV G FY MD YV R I A V A GL GKL L FAQF T EL MIEY Y S NG 409
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 440 LP S NL TASSNP S L DYG F KG AE IAMA S Y C SELQYLANPVT S HV Q SAEQHNQD V NSL G LIS S RKT S EA V DILKLM STTF L VG 519
Cdd:TIGR04473 410 LP G NL SLGPDL S V DYG L KG LD IAMA A Y S SELQYLANPVT T HV H SAEQHNQD I NSL A LIS A RKT E EA L DILKLM IASH L TA 489
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 520 I CQAVDLR H LEE N L RQT V K N T VS QV A KKV ltt G INGE lhpsrf CEKD LL K V VDREQ V F TY VDD PC SA T Y PL MQR L R Q VIV 599
Cdd:TIGR04473 490 M CQAVDLR Q LEE A L VKV V E N V VS TL A DEC --- G LPND ------ TKAR LL Y V AKAVP V Y TY LES PC DP T L PL LLG L K Q SCF 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 600 D HA L SNGETEKNAVTSIFQKIGA FE EE L KAV L PK E VE A A R AA Y --- G NG TA PIPN --- RI KECRSY P L YRFVREEL G T KL 673
Cdd:TIGR04473 561 D SI L ALHKKDGIETDTLVDRLAE FE KR L SDR L EN E MT A V R VL Y ekk G HK TA DNND alv RI QGSKFL P F YRFVREEL D T GV 640
650 660 670 680
....*....|....*....|....*....|....*....|
gi 15231778 674 LTGEKVVS P G E EFD KVF T A MCE G KLID PL MD CL KEWN G A P 713
Cdd:TIGR04473 641 MSARREQT P Q E DVQ KVF D A IAD G RITV PL LH CL QGFL G Q P 680
Lyase_aromatic
pfam00221 Aromatic amino acid lyase; This family includes proteins with phenylalanine ammonia-lyase, EC: ...
64-533
0e+00
Aromatic amino acid lyase; This family includes proteins with phenylalanine ammonia-lyase, EC:4.3.1.24, histidine ammonia-lyase, EC:4.3.1.3, and tyrosine aminomutase, EC:5.4.3.6, activities.
Pssm-ID: 459718
Cd Length: 464
Bit Score: 563.20
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 64 LT IGQ V A A IST vg G SV KVEL AETS R AG V K AS SDWVM E SMNK G TDS YGV T TGFGA TSHR R T -- KNGTA LQ TE LIR FLN AG I 141
Cdd:pfam00221 1 LT LED V V A VAR -- G GA KVEL SPEA R ER V A AS RALLE E ILAE G RPV YGV N TGFGA LADV R I pp EDLEQ LQ RN LIR SHA AG V 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 142 F gntketc HT LP QSAT RA A ML V R V N T L LQ GYSG I R F E IL E AITS LLN HN I S P SL P L RG TIT ASGDL V PL SY IA GL L T G RP 221
Cdd:pfam00221 79 G ------- EP LP EEVV RA M ML L R L N S L AR GYSG V R P E VV E RLVA LLN AG I T P VV P E RG SVG ASGDL A PL AH IA LA L I G EG 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 222 NSKA tgp D GE SLT A K EA FEK AG IS tg FFD L Q PKEGLAL V NGTAV GSGM A SMV L FE A NVQAV LA E V LS A IFA E VMS G KPEF 301
Cdd:pfam00221 152 EVYY --- K GE RMP A A EA LAA AG LE -- PLE L G PKEGLAL I NGTAV MTAL A ALA L HD A ERLLR LA D V AA A LSL E ALR G SDDP 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 302 T D HLT H R L KH HPGQIE A AA IMEHI L D GS SYMK laqkvh EMDPLQKPK QD R Y A LR TS PQ WL G PQIEVIRQ A TKSI E R E I NS 381
Cdd:pfam00221 227 F D PRI H A L RP HPGQIE V AA NLRAL L A GS ELIR ------ SHPDCARLV QD P Y S LR CA PQ VH G AARDALAY A REVL E I E L NS 300
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 382 V N DNPL I D VSRNKAIH GGNF Q G T P IGVS MD NTRL A I A AI G K L MFAQFSE LVN DFY NNGLP SN L T A s SN P S L DY GF KG A EI 461
Cdd:pfam00221 301 V T DNPL V D FEDGEVLS GGNF H G Q P VALA MD FLAI A L A EL G N L SERRIAR LVN PAL NNGLP PF L A A - DD P G L NS GF MI A QY 379
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15231778 462 AM A SYC SE LQY LA N P VTSHVQSAEQHNQ D VN S L G L I SS RK TSEA V DI L KLMSTTF L VGIC QA V DLR HLEEN L 533
Cdd:pfam00221 380 TA A ALV SE NKV LA H P ASVDSIPTSAGQE D HV S M G T I AA RK LRQI V EN L ERVLAIE L LAAA QA L DLR RRPLK L 451
PAL-HAL
cd00332 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); PAL and HAL are members ...
62-527
0e+00
Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); PAL and HAL are members of the Lyase class I_like superfamily of enzymes that, catalyze similar beta-elimination reactions and are active as homotetramers. The four active sites of the homotetrameric enzyme are each formed by residues from three different subunits. PAL, present in plants and fungi, catalyzes the conversion of L-phenylalanine to E-cinnamic acid. HAL, found in several bacteria and animals, catalyzes the conversion of L-histidine to E-urocanic acid. Both PAL and HAL contain the cofactor 3, 5-dihydro-5-methylidene-4H-imidazol-4-one (MIO) which is formed by autocatalytic excision/cyclization of the internal tripeptide, Ala-Ser-Gly. PAL is being explored as enzyme substitution therapy for Phenylketonuria (PKU), a disorder which involves an inability to metabolize phenylalanine. HAL failure in humans results in the disease histidinemia.
Pssm-ID: 176460 [Multi-domain]
Cd Length: 444
Bit Score: 549.81
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 62 ET LT IGQ V A A IST vg G SV KVEL AETS R AG V K AS SDWVM E SMNK G TDS YGV T TGFGA TSHR R TKNG -- T ALQ TE L I R FLN A 139
Cdd:cd00332 1 GS LT LED V V A VAR -- G GE KVEL SPEA R ER V D AS RAALE E AAAE G KPV YGV N TGFGA LADV R IDDA dl R ALQ RN L L R SHA A 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 140 G IFG ntketch T LP QSAT RAAML V R V N T L LQ G Y SG I R F E I LE AITS LLN HNIS P SL P L RG TIT ASGDL V PL SY IA GL L T G 219
Cdd:cd00332 79 G VGP ------- P LP EEVV RAAML L R L N S L AR G H SG V R P E V LE RLVA LLN AGVT P VV P E RG SVG ASGDL A PL AH IA LA L I G 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 220 RPNSKA tgp D GE SLT A K EA FEK AG IST gf FD L QP KEGLAL V NGTAV GSGM A SMV L FE A NVQAV LA EVLS A IFA E VMS G KP 299
Cdd:cd00332 152 EGEVFY --- K GE RMP A A EA LAR AG LEP -- LE L GA KEGLAL I NGTAV MTAL A ALA L HD A ERLLD LA DIAG A LSL E ALR G SD 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 300 EFT D HLT H RLKH HPGQIE A AA IMEHI L D GSS YM klaqkvh E MDPLQKPK QD R Y A LR TS PQ WL G PQIEVI R Q A TKSI E R E I 379
Cdd:cd00332 227 APF D PRI H AARP HPGQIE V AA NLRAL L A GSS LW ------- E SHDGERRV QD P Y S LR CA PQ VH G AARDAL R Y A ARVL E I E L 299
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 380 NSV N DNPL I D VSRNKAIH GGNF Q G T P IGVS MD NTRL A I A AIGK L MFAQFSE LVN DFY n N GLP SN L T A ss N P S L DY GF KG A 459
Cdd:cd00332 300 NSV T DNPL V D PDNGEVLS GGNF H G Q P VALA MD FLAI A L A ELAN L SERRIAR LVN PAL - S GLP AF L V A -- D P G L NS GF MI A 376
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15231778 460 EIAM A SYCS E LQY LA N P VTSHVQSAEQHNQ D VN S L GLI SS RK TS E A VD I L KLMSTTF L VGIC QA V DLR 527
Cdd:cd00332 377 QYTA A ALVA E NKA LA H P ASVDSIPTSAGQE D HV S M GLI AA RK LR E I VD N L RRILAIE L LAAA QA L DLR 444
HutH
COG2986 Histidine ammonia-lyase [Amino acid transport and metabolism];
54-603
4.85e-135
Histidine ammonia-lyase [Amino acid transport and metabolism];
Pssm-ID: 442225
Cd Length: 503
Bit Score: 407.54
E-value: 4.85e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 54 RPV V N L G G ET LT IGQ V A A IST vg G SV KVEL AETS RA GVK AS SDW V M E SMNK G TDS YGV T TGFGA TSHR R -- TKNGTA LQ T 131
Cdd:COG2986 2 MTT V T L D G GS LT LED V V A VAR -- G GA KVEL SPEA RA RIE AS RAF V E E IAAE G KPV YGV N TGFGA LADV R ip PEDLEE LQ R 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 132 E LIR FLN AG I f G NT ketcht LP QSAT RA A ML V R V N T L LQ GYSG I R F E IL E AITS LLN HNIS P SL P LR G TIT ASGDL V PL S 211
Cdd:COG2986 80 N LIR SHA AG V - G EP ------ LP EEVV RA M ML L R L N S L AR GYSG V R P E VV E RLVA LLN AGVT P VV P EK G SVG ASGDL A PL A 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 212 YI A GL L T G R pnskat G P --- D GE SLT A K EA FEK AG IST gf FD L QP KEGLAL V NGT A V GSGM A SMV LF E A NVQAV LA E V LS 288
Cdd:COG2986 153 HL A LA L I G E ------ G E vfy K GE RMP A A EA LAE AG LEP -- LT L GA KEGLAL I NGT Q V MTAL A ALA LF D A ERLLD LA D V AA 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 289 A IFA E VMS G KPEFT D HLT H R L KH HPGQI EA AA IMEHI L D GS sym K L AQKVHEMDPL Q kpkq D R Y A LR TS PQ WL G PQIEVI 368
Cdd:COG2986 225 A LSL E ALL G SDAPF D PRI H A L RP HPGQI AV AA NLRAL L A GS --- E L VESHRNCRRV Q ---- D P Y S LR CA PQ VH G AVRDAL 297
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 369 RQ A TKSI E R E I NSV N DNPL IDVSRNKA I H GGNF Q G T P IGVS MD NTRL A I A AIGKLMFAQFSE LV NDFYNN GLP SN L TA ss 448
Cdd:COG2986 298 AY A REVL E I E L NSV T DNPL VFPDEGEV I S GGNF H G Q P VALA MD FLAI A L A ELANISERRIAR LV DPALSH GLP PF L VP -- 375
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 449 N P S L DY GF KG A EIAM A SYC SE LQY LA N P VTSHVQSAEQHNQ D VN S L G L I SS RK TSEA V DI L KLMSTTF L VGIC QA V DLR h 528
Cdd:COG2986 376 D P G L NS GF MI A QYTA A ALV SE NKT LA H P ASVDSIPTSANQE D HV S M G T I AA RK LRRI V EN L EQVLAIE L LAAA QA L DLR - 454
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15231778 529 leenlrqtvkntvsqvakkvlttgin G E L HP S RFC E K d LLKV V d RE Q V FTYVD D pc SATY P LMQRLRQV I VDH AL 603
Cdd:COG2986 455 -------------------------- G P L KL S PGT E A - AYAA V - RE V V PFLDE D -- RPLA P DIEAAAEL I RSG AL 499
PRK09367
PRK09367 histidine ammonia-lyase; Provisional
56-527
5.01e-91
histidine ammonia-lyase; Provisional
Pssm-ID: 236484
Cd Length: 500
Bit Score: 293.18
E-value: 5.01e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 56 VVN L GGE TLT IGQVA A IST vg GSV KVEL AETS RA GVK AS SDW V MESMNK G TDS YG VT TGFG ATSHR R TKNG -- TA LQ TE L 133
Cdd:PRK09367 3 TIT L TPG TLT LEDLR A VAR -- EGA KVEL DPSA RA AIA AS RAV V ERIVAE G RPV YG IN TGFG KLASV R IAPE dl EQ LQ RN L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 134 IRFLN AG I f G NT ketcht LP QSAT R AA ML V R V N T L LQ G Y SG I R F E IL EA ITS LLN HNIS P SL P LR G TIT ASGDL V PL SYI 213
Cdd:PRK09367 81 VLSHA AG V - G EP ------ LP EEVV R LM ML L R L N S L AR G H SG V R P E VI EA LLA LLN AGVT P VI P EK G SVG ASGDL A PL AHM 153
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 214 A GL L T G R pn SK A T g PD GE S L T A K EA FE KAG IST gf FD L QP KEGLAL V NGT AVGSGM A SMV LF E A NVQAVL A E V LS A IFA E 293
Cdd:PRK09367 154 A LV L L G E -- GE A F - YK GE R L P A A EA LA KAG LEP -- VT L AA KEGLAL I NGT QASTAL A LLG LF D A EDLLAA A D V AG A LSV E 228
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 294 VMS G -- K P e F TDHL t H R L KH HPGQI EA AA IMEHI L D GSS YMKLAQKVHEM dplqkpk QD R Y A LR TS PQ WL G PQIEVI R Q A 371
Cdd:PRK09367 229 ALL G sd A P - F DARI - H A L RG HPGQI DV AA NLRAL L E GSS IITSSHDCERV ------- QD P Y S LR CQ PQ VH G ACLDQL R Y A 299
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 372 TKSI E R E I N S V N DNPL I d VSRNKA I H GGNF Q G T P IGVSM D NTRL A I A A IG KL mfaqf SE ----- LV N df YN - N GLP SN L T 445
Cdd:PRK09367 300 AEVL E I E A N A V T DNPL V - FPDGDV I S GGNF H G E P VAFAA D FLAI A V A E IG SI ----- SE rriar LV D -- PA l S GLP PF L V 371
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 446 A ss N P S L DY GF KG A EIAM A SYC SE LQY LA N P -- V T S HVQ SA E Q hn Q D VN S L G LISS RK TS E AVD ilklm STTFLVG I --- 520
Cdd:PRK09367 372 P -- D P G L NS GF MI A QVTA A ALV SE NKT LA H P as V D S IPT SA N Q -- E D HV S M G THAA RK LR E MAE ----- NLRRVLA I ell 442
....*....
gi 15231778 521 -- C Q AV D L R 527
Cdd:PRK09367 443 aa A Q GL D F R 451
hutH
TIGR01225 histidine ammonia-lyase; This enzyme deaminates histidine to urocanic acid, the first step in ...
57-546
5.15e-83
histidine ammonia-lyase; This enzyme deaminates histidine to urocanic acid, the first step in histidine degradation. It is closely related to phenylalanine ammonia-lyase. [Energy metabolism, Amino acids and amines]
Pssm-ID: 200086
Cd Length: 506
Bit Score: 271.96
E-value: 5.15e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 57 V N L G G ET LT IGQ V A A ISTV G gs VK V E L AETS R AG V KA S SDWVMESMNKGTDS YG VT TGFG ATSHR R -- TKNGTA LQ TE L I 134
Cdd:TIGR01225 1 V T L D G GS LT LED V V A VARH G -- AR V S L SAAA R EA V AK S RAAIEQIIAGDETV YG IN TGFG KLAST R id SEDLAE LQ RN L V 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 135 R FLN AG I f G NT ketcht L PQSAT RA A M LV R V N T L LQ GYSG I R F E I L EAITS LLN HNIS P SL P LR G TIT ASGDL V PL SYI A 214
Cdd:TIGR01225 79 R SHA AG V - G DP ------ L DEEVV RA I M AL R L N S L AK GYSG V R A E V L DQLIA LLN AGVH P VV P EK G SVG ASGDL A PL AHM A 151
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 215 GL L T G R pn S KA T g PD GE SLT A K EA FEK AG IST gf FD L QP KEGLAL V NGT AVGSGM A SMV LF E A NVQAVL A EVLS A IFA E V 294
Cdd:TIGR01225 152 LV L M G E -- G KA F - FK GE RMP A A EA LAA AG LEP -- VT L AA KEGLAL I NGT QAMTAL A LLA LF D A EDLLRA A DITA A LSV E A 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 295 MS G KPEFT D HLT H RLKH H P GQI EA AA IMEHI L D GS SYMKLAQ --- K V hemdplqkpk QD R Y A LR TS PQ WL G PQIEVIR Q A 371
Cdd:TIGR01225 227 LL G TTKPF D PDI H EARP H R GQI DV AA RFREL L A GS EITLSHR dcd R V ---------- QD A Y S LR CQ PQ VH G AVLDTLD Q V 296
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 372 TKSIER E I NS VN DNPL IDVSRNKAIH GGNF Q G T P IGVSM D NTRL AIA AI G KLMFAQFSE L VND f YNN GLP SN L TA ss NPS 451
Cdd:TIGR01225 297 AEVLGI E L NS AT DNPL VFADGGEVVS GGNF H G E P VALAA D FLAI AIA EL G SISERRIER L LDP - NLS GLP PF L AP -- DGG 373
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231778 452 L DY GF KG A EIAM A SYC SE LQY L AN P -- V T S HVQ SA E Q hn Q D VN S L G LISS RK TS E AVDILKLMSTTF L VGI CQ AVDL R HL 529
Cdd:TIGR01225 374 L NS GF MI A QYTA A ALV SE NKA L SH P as V D S IPT SA N Q -- E D HV S M G AHAA RK LR E MIENVRRVIAIE L LAA CQ GLEF R DP 451
490 500
....*....|....*....|...
gi 15231778 530 E ------ E NLR Q T V KNT V SQVAK 546
Cdd:TIGR01225 452 L ktsakl E KAY Q A V RSV V APLDG 474
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
