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Conserved domains on  [gi|15231217|ref|NP_190156|]
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Major facilitator superfamily protein [Arabidopsis thaliana]

Protein Classification

NRT1/PTR family MFS transporter( domain architecture ID 13024493)

NRT1/PTR (nitrate transporter/peptide transporter) family major facilitator superfamily (MFS) transporter is a proton-coupled transporter that facilitates the transport of one or more from a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_NPF1_2 cd17416
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; ...
23-529 0e+00

NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF1 includes Medicago truncatula LATD/NIP, now named MtNPF1.7, which is a high-affinity nitrate transporter and is involved in nodulation and root architecture. NPF2 members are well-established nitrate and glucosinolate transporters, including Arabidopsis nitrate influx and efflux transporters with varied tissue and developmental specificity. Examples are AtNPF2.7, which is expressed in the cortex of mature roots, and AtNPF2.9, which is expressed in root companion cells where it is involved in phloem loading. NPF1/2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340974 [Multi-domain]  Cd Length: 444  Bit Score: 594.24  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  23 LPFMLVTLLGMSITYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFISLTGI 102
Cdd:cd17416   1 MPFIIGNETGEKLASYGLLANLIVYLIEEYNMKSIAAANIINIWSGTTNFLPVVGAFLSDSYFGRFPTISVGSFASLLGM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 103 SLLTLIASLDYLRPRPCETGSILCQSPSKLQLGILYAALALVITGTAGTRFILASAGANQYKKPKEQGR-----FFNWYF 177
Cdd:cd17416  81 VLLTLTAAIPSLRPPPCETASSLCQSPSKLQLAVLYSALALLSIGAGGIRPCSLAFGADQFDKKTESGKrglesFFNWYY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 178 FTLYGGAITGTTAIVYAQDNASWKLGFGLCVAANLISFIIFVAGKRLYEhdqplgspytslvrvlvaatmkrkavisykd 257
Cdd:cd17416 161 FTFTVAQIISLTAIVYIQDNVSWKIGFGIPAALMLLSFILFLAGSRLYV------------------------------- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 258 edyhhreleketktyvampsksfrflnraalktegdsnnnmwrlcsvqeVEDFKAVLRLVPLWTSVMFLSAPLAVQMSMT 337
Cdd:cd17416 210 -------------------------------------------------VEDLKSLIRVIPIWSTGIILSLAMAQQMSLT 240
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 338 VLQAMVMDRKLGPHFKVSAGSMQVIALVSGCVFIILNNWTTYPMYQKLIR--KPLTPLQKVGIGHVLTILSMAISAVVEA 415
Cdd:cd17416 241 VLQALVMDRHLGPSFQIPAGSITVFLLITLTIFIPLYDRVLVPLLRKITGrgRGLTLLQRVGIGIVFSILSMAVAAIVER 320
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 416 KRLKTVEN----SHLMSVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRNTATSLTSVVMGISFYLSTALIDVIQRT 491
Cdd:cd17416 321 KRRKTALTqgngTSPMSVLWLVPQLVLMGIAEAFHFIGQIEFFYQEFPESMRSTATSLFSLGMGVASYLSSALISAVHRT 400
                       490       500       510       520
                ....*....|....*....|....*....|....*....|....
gi 15231217 492 TK------WLPNDINHGRVDNVYLVLVIIGVSNFGYFLVCSWFY 529
Cdd:cd17416 401 TGrggggsWLPDDINKGRLDYVYWLLAGLGALNLGYFLVCSWRY 444
 
Name Accession Description Interval E-value
MFS_NPF1_2 cd17416
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; ...
23-529 0e+00

NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF1 includes Medicago truncatula LATD/NIP, now named MtNPF1.7, which is a high-affinity nitrate transporter and is involved in nodulation and root architecture. NPF2 members are well-established nitrate and glucosinolate transporters, including Arabidopsis nitrate influx and efflux transporters with varied tissue and developmental specificity. Examples are AtNPF2.7, which is expressed in the cortex of mature roots, and AtNPF2.9, which is expressed in root companion cells where it is involved in phloem loading. NPF1/2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340974 [Multi-domain]  Cd Length: 444  Bit Score: 594.24  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  23 LPFMLVTLLGMSITYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFISLTGI 102
Cdd:cd17416   1 MPFIIGNETGEKLASYGLLANLIVYLIEEYNMKSIAAANIINIWSGTTNFLPVVGAFLSDSYFGRFPTISVGSFASLLGM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 103 SLLTLIASLDYLRPRPCETGSILCQSPSKLQLGILYAALALVITGTAGTRFILASAGANQYKKPKEQGR-----FFNWYF 177
Cdd:cd17416  81 VLLTLTAAIPSLRPPPCETASSLCQSPSKLQLAVLYSALALLSIGAGGIRPCSLAFGADQFDKKTESGKrglesFFNWYY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 178 FTLYGGAITGTTAIVYAQDNASWKLGFGLCVAANLISFIIFVAGKRLYEhdqplgspytslvrvlvaatmkrkavisykd 257
Cdd:cd17416 161 FTFTVAQIISLTAIVYIQDNVSWKIGFGIPAALMLLSFILFLAGSRLYV------------------------------- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 258 edyhhreleketktyvampsksfrflnraalktegdsnnnmwrlcsvqeVEDFKAVLRLVPLWTSVMFLSAPLAVQMSMT 337
Cdd:cd17416 210 -------------------------------------------------VEDLKSLIRVIPIWSTGIILSLAMAQQMSLT 240
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 338 VLQAMVMDRKLGPHFKVSAGSMQVIALVSGCVFIILNNWTTYPMYQKLIR--KPLTPLQKVGIGHVLTILSMAISAVVEA 415
Cdd:cd17416 241 VLQALVMDRHLGPSFQIPAGSITVFLLITLTIFIPLYDRVLVPLLRKITGrgRGLTLLQRVGIGIVFSILSMAVAAIVER 320
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 416 KRLKTVEN----SHLMSVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRNTATSLTSVVMGISFYLSTALIDVIQRT 491
Cdd:cd17416 321 KRRKTALTqgngTSPMSVLWLVPQLVLMGIAEAFHFIGQIEFFYQEFPESMRSTATSLFSLGMGVASYLSSALISAVHRT 400
                       490       500       510       520
                ....*....|....*....|....*....|....*....|....
gi 15231217 492 TK------WLPNDINHGRVDNVYLVLVIIGVSNFGYFLVCSWFY 529
Cdd:cd17416 401 TGrggggsWLPDDINKGRLDYVYWLLAGLGALNLGYFLVCSWRY 444
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
90-496 7.07e-59

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 200.62  E-value: 7.07e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217    90 VISASAFISLTGISLLTLiASLDYLRPrpcetgsilcqspsKLQLGILYAALALVITGTAGTRFILASAGANQYKK--PK 167
Cdd:pfam00854   3 TIFLGSIIYAIGHILLAL-SAIPSLRP--------------PVHVALFFIGLALIALGTGGIKPNVSSFGGDQFEEtdPR 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217   168 EQGRFFNWYFFTLYGGAITGTTAIVYAQDNASWKLGFGLCVAANLISFIIFVAGKRLYEHDQPLGSPYTSLVRVLVAATM 247
Cdd:pfam00854  68 RRSRFFSIFYFSINAGSLISTIITPYLQQNYGYPLGFGLPAVGMIIALLVFLLGSRMYKKKPPKGNVLTKVFKVLPVAAW 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217   248 KRKAvisykdedyHHRELEKETKTYVAMPSKSFRFLNRAALKTEGDSNNNMwrlCSVQEVEDFKAVLRLVPLWTSVMFLS 327
Cdd:pfam00854 148 NKVK---------LNGSSAGIKKLHWLDWARELDALIILGIVVPGIFFNIW---CTKTKVEEVKRLLRVLPLFLPLIMFW 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217   328 APLAVQMSMTVLQAMVMDRKLGpHFKVSAGSMQVIALVSGCVFIILNNWTTYPMYQKLiRKPLTPLQKVGIGHVLTILSM 407
Cdd:pfam00854 216 ALYDQMGTSWVLQARTMNRKIG-SFEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRKC-TGGLTPLQKMAVGLFLASLAF 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217   408 AISAVVEAKRLKTV-----ENSHLMSVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRNTATSLTSVVMGISFYLST 482
Cdd:pfam00854 294 AIAAIVQLKRNDTGpefpiAQEVPISVLWLIPQYLLIGFGELFISIGGLEFFYKLAPKSMTSLITGLFLLTNALGNFLSG 373
                         410
                  ....*....|....
gi 15231217   483 ALIDVIQRTTKWLP 496
Cdd:pfam00854 374 VIATLTAKPTNVLG 387
2A1704 TIGR00926
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ...
36-422 4.40e-15

Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273343 [Multi-domain]  Cd Length: 654  Bit Score: 78.26  E-value: 4.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217    36 TYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISasaFISLTGISLLTLIAsldylr 115
Cdd:TIGR00926   2 SYYGMRTILVLYFLNFLGFSESTSTVLFHTFTYLCYLTPLIGAIIADGWLGKFKTIL---YLSIVYVVGHALLS------ 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217   116 prpceTGSI-LCQSPSKLQLGILyaALALVITGTAGTRFILASAGANQYKKPKEQGRFFNWYFFTLYGGA----ITGTTA 190
Cdd:TIGR00926  73 -----FGAIpSSGHPLHDLLDLL--GLALIALGTGGIKPCVSAFGGDQFEERQLSLRSRFFSFFYFAINAgsliSTIITP 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217   191 IVYAQ-----DNASWKLGFGLCVAANLISFIIFVAGKRLYEHDQPLGSPYTSLVRVLVAATMKRKAVISyKDEDYHHREL 265
Cdd:TIGR00926 146 ILRGDvgcfgCQDCYPLAFGVPAILMILALIVFMAGSKMYKKKPPKGNIVSKVIKCIVTALRKRFSTRS-EHWPLHWLDY 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217   266 EKETKtyvampsksfrflnraalktegdsnnnmwrlcSVQEVEDFKAVLRLVPLWTSVMFLSAPLAVQMSMTVLQAMVMD 345
Cdd:TIGR00926 225 AKDKH--------------------------------DIRMIRSTKRLLRVLVLFIPLPMFWALFDQQGSRWTLQATRMD 272
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15231217   346 RKLGpHFKVSAGSMQVIALVsgcVFIILNNWTTYPMYQKL--IRKPLTPLQKVGIGHVLTILSMAISAVVEAKRLKTVE 422
Cdd:TIGR00926 273 GDVG-GFEIQPDQMQVVNPL---LILIFVPIFDYIVYPAIakCGTRFTSLRKMAVGGLLAALSFFVAALVQLKVNPTLP 347
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
68-484 1.00e-12

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 70.23  E-value: 1.00e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  68 GVVNMLPVVAAILADSFFGNIPVISASAFISLTGISLLTLIASLdylrprpcetgsilcqspsklqlGILYAALALVITG 147
Cdd:COG3104  66 ALVYLTPLLGGWLADRLLGQRRAILLGGILMALGHFLLALPGGV-----------------------TLFYLGLALIAVG 122
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 148 TAgtrFILASAGA---NQYkkPKEQGRF---FNWYFFTLYGGAITGTTAIVYAQDNASWKLGFGLCVAANLISFIIFVAG 221
Cdd:COG3104 123 NG---LFKPNISSlvgQLY--DPGDPRRdagFTIFYMGINIGAFLAPLLCGYLGEKYGWHYGFGAAAIGMLIGLIIFLLG 197
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 222 KRLYEH-----DQPLGSPYTSLVRVLVAATMKRKAVISYKDEDYHHrelekeTKTYVAMPSKSFRFLNRAALKTegdsnn 296
Cdd:COG3104 198 RKYLGDiglepDNPLSKKERLIAVALGALLLVLVLAGLLSNANIAN------YLLYVIAIIAYFIFILRSKKLT------ 265
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 297 nmwrlcsvqeVEDFKAVLRLVPLW-TSVMFLSapLAVQMSMTV-LQAM-VMDRKLGPhFKVSAGSMQVIalvsGCVFII- 372
Cdd:COG3104 266 ----------KEERKRLLAILILFlFSIVFWA--LYEQAGTSLnLFADrNVDRSLFG-FEIPPSWFQSL----NPLFIIi 328
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 373 ---LNNWttypMYQKLIRKPLTP--LQKVGIGHVLTILSMAISAVVEakrlKTVENSHLMSVLWLVPALVINGIGEAFHF 447
Cdd:COG3104 329 lapVFAA----LWTKLGKRGKEPstPTKFALGLLLLGLGFLVMALAA----LLAGAGGKVSPLWLVLAYLLLTIGELCLS 400
                       410       420       430
                ....*....|....*....|....*....|....*..
gi 15231217 448 PANIAIFYGEFPEslrntatSLTSVVMGIsFYLSTAL 484
Cdd:COG3104 401 PVGLSMITKLAPA-------RFAGQMMGL-WFLATAL 429
PRK15462 PRK15462
dipeptide permease;
36-227 2.30e-05

dipeptide permease;


Pssm-ID: 237971 [Multi-domain]  Cd Length: 493  Bit Score: 46.87  E-value: 2.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217   36 TYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFisLTGISLLTLIASldylr 115
Cdd:PRK15462  24 SFYGMRALLILYLTNQLKYDDNHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVMLGAL--LMAIGHVVLGAS----- 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  116 prpcetgsilcqspsKLQLGILYAALALVITGTAGTRFILASAGANQYK--KPKEQGRFFnwyffTLYG----GAITGTT 189
Cdd:PRK15462  97 ---------------EIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYEptDPRRDGGFS-----LMYAagnvGSIIAPI 156
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 15231217  190 AIVYAQDNASWKLGFGLCVAANLISFIIFVAGKRLYEH 227
Cdd:PRK15462 157 ACGYAQEEYSWAMGFGLAAVGMIAGLVIFLCGNRHFTH 194
 
Name Accession Description Interval E-value
MFS_NPF1_2 cd17416
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; ...
23-529 0e+00

NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF1 includes Medicago truncatula LATD/NIP, now named MtNPF1.7, which is a high-affinity nitrate transporter and is involved in nodulation and root architecture. NPF2 members are well-established nitrate and glucosinolate transporters, including Arabidopsis nitrate influx and efflux transporters with varied tissue and developmental specificity. Examples are AtNPF2.7, which is expressed in the cortex of mature roots, and AtNPF2.9, which is expressed in root companion cells where it is involved in phloem loading. NPF1/2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340974 [Multi-domain]  Cd Length: 444  Bit Score: 594.24  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  23 LPFMLVTLLGMSITYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFISLTGI 102
Cdd:cd17416   1 MPFIIGNETGEKLASYGLLANLIVYLIEEYNMKSIAAANIINIWSGTTNFLPVVGAFLSDSYFGRFPTISVGSFASLLGM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 103 SLLTLIASLDYLRPRPCETGSILCQSPSKLQLGILYAALALVITGTAGTRFILASAGANQYKKPKEQGR-----FFNWYF 177
Cdd:cd17416  81 VLLTLTAAIPSLRPPPCETASSLCQSPSKLQLAVLYSALALLSIGAGGIRPCSLAFGADQFDKKTESGKrglesFFNWYY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 178 FTLYGGAITGTTAIVYAQDNASWKLGFGLCVAANLISFIIFVAGKRLYEhdqplgspytslvrvlvaatmkrkavisykd 257
Cdd:cd17416 161 FTFTVAQIISLTAIVYIQDNVSWKIGFGIPAALMLLSFILFLAGSRLYV------------------------------- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 258 edyhhreleketktyvampsksfrflnraalktegdsnnnmwrlcsvqeVEDFKAVLRLVPLWTSVMFLSAPLAVQMSMT 337
Cdd:cd17416 210 -------------------------------------------------VEDLKSLIRVIPIWSTGIILSLAMAQQMSLT 240
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 338 VLQAMVMDRKLGPHFKVSAGSMQVIALVSGCVFIILNNWTTYPMYQKLIR--KPLTPLQKVGIGHVLTILSMAISAVVEA 415
Cdd:cd17416 241 VLQALVMDRHLGPSFQIPAGSITVFLLITLTIFIPLYDRVLVPLLRKITGrgRGLTLLQRVGIGIVFSILSMAVAAIVER 320
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 416 KRLKTVEN----SHLMSVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRNTATSLTSVVMGISFYLSTALIDVIQRT 491
Cdd:cd17416 321 KRRKTALTqgngTSPMSVLWLVPQLVLMGIAEAFHFIGQIEFFYQEFPESMRSTATSLFSLGMGVASYLSSALISAVHRT 400
                       490       500       510       520
                ....*....|....*....|....*....|....*....|....
gi 15231217 492 TK------WLPNDINHGRVDNVYLVLVIIGVSNFGYFLVCSWFY 529
Cdd:cd17416 401 TGrggggsWLPDDINKGRLDYVYWLLAGLGALNLGYFLVCSWRY 444
MFS_NPF cd17351
Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant ...
24-528 8.35e-104

Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340909 [Multi-domain]  Cd Length: 445  Bit Score: 319.18  E-value: 8.35e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  24 PFMLVTLLGMSITYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFISLTGIS 103
Cdd:cd17351   2 PFILGNEFAERLAFYGIAVNLVTYLTKVMHLSNAKAANTVTNFSGTSYLTPLLGAFLADAYLGRYWTIAIFSVIYLVGLI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 104 LLTLIASLDYLRPRPCETGSiLCQSPSKLQLGILYAALALVITGTAGTRFILASAGANQY-----KKPKEQGRFFNWYFF 178
Cdd:cd17351  82 LLTLSASVPSLRPPPCNPDS-PCEPASSTQLTVLYVGLYLIALGTGGIKPCVSAFGADQFdetdpKEKKQKPSFFNWFYF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 179 TLYGGAITGTTAIVYAQDNASWKLGFGLCVAANLISFIIFVAGKRLYehdqplgspytslvrvlvaatmkrkavisykde 258
Cdd:cd17351 161 SINLGSLLAVTLVVYIQDNVSWGWGFGIPAAAMALAVIVFVAGTPFY--------------------------------- 207
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 259 dyhhRELeketktyvampsksfrflnraalktegdsnnnmwrlcsvqevedfKAVLRLVPLWTSVMFLSAPLAVQMSMTV 338
Cdd:cd17351 208 ----REV---------------------------------------------KCLLRLLPIWATTILLSTVYAQMQTFFV 238
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 339 LQAMVMDRKLGPHFKVSAGSMQVIALVSGCVFIilnnwttyPMYQKLI----RK------PLTPLQKVGIGHVLTILSMA 408
Cdd:cd17351 239 QQGLTMDRRLGGSFEIPAASLSVFSTLFVLLFI--------PLYDRVFvpfaRRytgnprGITPLQRIGIGLVLSILAMA 310
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 409 ISAVVEAKRLKTVENSHL---------MSVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRNTATSLTSVVMGISFY 479
Cdd:cd17351 311 VAALVEVKRLRVARAHGLldsptgvvpMSVFWLLPQYFLLGLAEVFTYIGQLEFFYDEAPDGMRSLGTALFLLTIALGNF 390
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15231217 480 LSTALIDVIQRTTK------WLPNDINHGRVDNVYLVLVIIGVSNFGYFLVCSWF 528
Cdd:cd17351 391 LSSALVTIVNKITGkgggpgWLPNNLNKGRLDYFYWLLAVLSAVNFLVFLVCAKW 445
MFS_NPF3 cd17415
NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The ...
20-528 1.64e-87

NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF3 is the smallest NPF subfamily and it includes Cucumis sativus nitrite transporter (CsNitr1), now named CsNPF3.2. It functions as a chloroplast nitrite uptake transporter to remove toxic nitrite from the cytosol. NPF3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340973 [Multi-domain]  Cd Length: 448  Bit Score: 277.41  E-value: 1.64e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  20 WITLPFMLVTLLGMSITYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFISL 99
Cdd:cd17415   1 WKTMPFIFGNEICERLASVGFHTNLITYLTLQLHMPLVKAANILTNFNGTASLTPLLGAFIADSFAGRFWTITIGSIIYQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 100 TGISLLTLIASLDYLRPRPCETGSILCQSPSKLQLGILYAALALVITGTAGTRFILASAGANQY--KKPKEQGR---FFN 174
Cdd:cd17415  81 LGMVLLTISAILPSLRPPPCNGHEVCACQASSAQLSILYLSLLLTALGSGGIRPCVVAFGADQFdeSDPKQAKQtwnFFN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 175 WYFFTLYGGAITGTTAIVYAQDNASWKLGFGLCVAANLISFIIFVAGKRLYehdqplgspytslvrvlvaatmkrkavis 254
Cdd:cd17415 161 WYYFCMGIAILLAVTVIVYIQDNVGWGWGFGIPTIAMAISVIAFVVGSPLY----------------------------- 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 255 ykdedyhhRELeketktyvampsksfrflnraalktegdsnnnmwrlcsvqevedfKAVLRLVPLWTSVMFLSAPLAVQM 334
Cdd:cd17415 212 --------REL---------------------------------------------KSIIRMLPIWAAGILLVTASSQQH 238
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 335 SMTVLQAMVMDRKLGPHFKVSAGSMQVIALVSGCVFIILNNWTTYPMYQKLIRKP--LTPLQKVGIGHVLTILSMAISAV 412
Cdd:cd17415 239 TFSIQQARTMNRHLTPSFQIPPASMSVFGILSLLTTVPLYDRVLMPVARKFTGNErgITFLQRMGIGLFISILATVVAAF 318
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 413 VEAKRLKTVENSHL---------MSVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRNTATSLTSVVMGISFYLSTA 483
Cdd:cd17415 319 VEVKRKSVAANHGLldrphatvpISVFWLVPQYILHGIAEAFMSIGHLEFFYDQSPESMRSTATALFWSTISLGSYLSTL 398
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|
gi 15231217 484 LIDVIQRTTK-----WLPNDINHGRVDNVYLVLVIIGVSNFGYFLVCSWF 528
Cdd:cd17415 399 LVTLVHKETSrggrwWLPNNLNRGRLDYFYWLVAVLQAVNLVYFLICARW 448
MFS_NPF5 cd17417
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The ...
20-531 1.27e-86

NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF5 includes Arabidopsis thaliana PTR3 (AtPTR3, now named AtNPF5.2), which is a wound-induced peptide transporter that is necessary for defense against virulent bacterial pathogens. NPF5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340975 [Multi-domain]  Cd Length: 452  Bit Score: 275.30  E-value: 1.27e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  20 WITLPFMLVTLLGMSITYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFISL 99
Cdd:cd17417   1 WKACSFIIGIEVAERFAYYGIASNLVTYLTTPLHQSTARAAKNVNNWSGTATLLPLLGAFVADAYLGRYRTILISSLIYL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 100 TGISLLTLIASLDYLRPRPCetgSILCQSPSKLQLGILYAALALVITGTAGTRFILASAGANQY--KKPKEQGR---FFN 174
Cdd:cd17417  81 LGLVLLTLSASLPSLKPPEC---NGTCSKASTLQVAFFFFSLYLVAIGQGGHKPCVQAFGADQFdeDDPKEKKQkssFFN 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 175 WYFFTLYGGAITGTTAIVYAQDNASWKLGFGLCVAANLISFIIFVAGKRLYEHdqplgspytslvrvlvaatmkrkavis 254
Cdd:cd17417 158 WWYFSICAGSLTAVTVLVYIQDNVGWALGFGIPTIVMALALFVFLLGTPLYRY--------------------------- 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 255 ykdedyhhreleketktyvampsksfrflnraalktegdsnnnmwrlcsvqEVEDFKAVLRLVPLW-TSVMFlSAPLAVQ 333
Cdd:cd17417 211 ---------------------------------------------------KVEEVKLVLRLIPIWfTTLVF-TVVFAQS 238
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 334 MSMTVLQAMVMDRKLGPHFKVSAGSMQVIALVSGCVFIILNNWTTYPMYQKLIRKP--LTPLQKVGIGHVLTILSMAISA 411
Cdd:cd17417 239 PTFFTKQGVTMDRTIGPNFKIPPASLQSFITLSILISIPIYDRVFVPIARKITGNPrgITLLQRIGIGMFLSILAMVIAA 318
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 412 VVEAKRLKTVENSHL--------MSVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRNTATSLTSVVMGISFYLSTA 483
Cdd:cd17417 319 LVEMKRLKVAKEHGLispkatvpMSIFWLLPQYILLGIADVFTMVGMQEFFYDQVPDEMRSLGTALYLSVFGVGSFLSSF 398
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....
gi 15231217 484 LIDVIQRTTK------WLPNDINHGRVDNVYLVLVIIGVSNFGYFLVCSWFYKY 531
Cdd:cd17417 399 LISIVDKITSssggqsWFNNNLNRAHLDYFYWLLAVLSAVNFVLFLFVAKSYVY 452
MFS_NPF7 cd17419
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The ...
20-526 6.49e-77

NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF7 includes the nitrate transporters AtNPF7.2 and AtNPF7.3, as well as the dipeptide transporter OsNPF7.3. AtNPF7.3 is a bidirectional transporter involved in nitrate influx and efflux. NPF7 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340977 [Multi-domain]  Cd Length: 447  Bit Score: 249.60  E-value: 6.49e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  20 WITLPFMLVTLLGMSITYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFISL 99
Cdd:cd17419   1 WKSAIFILVNQGLATLAYFGVGVNLVLYLTRVMHQSNASAANNVSNWTGTVYITPLIGAFLSDSYWGRYWTSTLFQAIFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 100 TGISLLTLIASLDYLRPRPCETGSILCQSPSKLQLGILYAALALVITGTAGTRFILASAGANQY-----KKPKEQGRFFN 174
Cdd:cd17419  81 IGLLLLTLSSALPSLRPPQCGDGDLKCPPASAAQTTFLYFSLYLIALGYGGYQPCIATLGADQFddedpIEKASKSAFFS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 175 WYFFTLYGGAITGTTAIVYAQDNASWKLGFGLCVAANLISFIIFVAGKRLYehdqplgspytslvrvlvaatmkrkavis 254
Cdd:cd17419 161 YFYQALNLGSLFSNTILVYFEDNGSWGLGFGISAGAAFIGLVLFLAGTPFY----------------------------- 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 255 ykdedyhhRELeketktyvampsksfrflnraalktegdsnnnmwrlcsvqevedfKAVLRLVPLWTSVMFLSAPLAVQM 334
Cdd:cd17419 212 --------REV---------------------------------------------KCILRLLPIWLSTIIYSVVYTQMA 238
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 335 SMTVLQAMVMDRKLGpHFKVSAGSMQVIALVSGCVFIILNNWTTYPMYQKLIRKP--LTPLQKVGIGHVLTILSMAISAV 412
Cdd:cd17419 239 TLFVEQGAAMDTSFG-NFKIPPASMSVFEILSVAVGTVLYRKFLVPLLRKVTGHPkgITELQRMGIGLVIGILAMVVAAL 317
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 413 VEAKRLKTVENSHL--------MSVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRNTATSLTSVVMGISFYLSTAL 484
Cdd:cd17419 318 VEIQRLKVARPSNLddptspspLSIFWQIPQYVLVGASEVFTYVGQLEFFYDQAPDGLRSLGSALCMASVALGNYLSSLL 397
                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*...
gi 15231217 485 IDVIQRTTK------WLPNDINHGRVDNVYLVLVIIGVSNFGYFLVCS 526
Cdd:cd17419 398 VTIVNKVTTkdgspgWIPDNLNKGHLDRFYWLLAALSGIDFVVFLICA 445
MFS_NPF6 cd17413
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The ...
20-526 1.19e-76

NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter 1/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF6 includes the first identified member of the NRT1/PTR family: Arabidopsis thaliana NRT1.1, now called AtNPF6.3. It is a dual affinity nitrate influx transporter and a nitrate sensor. It also transports auxin and has nitrate efflux activity. NPF6 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340971 [Multi-domain]  Cd Length: 457  Bit Score: 249.29  E-value: 1.19e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  20 WITLPFMLVTLLGMSITYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFISL 99
Cdd:cd17413   1 WKSAALILGIEMCERLTTLGIGVNLVTYLTGTMHLPSATSANIVTNFLGTSFLLCLLGGFIADTFLGRYLTIAIFASIQA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 100 TGISLLTLIASLDYLRPRPC-ETGSILCQSPSKLQLGILYAALALVITGTAGTRFILASAGANQY--KKPKEQGR---FF 173
Cdd:cd17413  81 LGVLVLTLSTTLPSLRPPPCnHTTSHHCEPASGIQLTVLYLALYLIALGTGGIKSSVSGFGSDQFdeNDPKERKLmsyFF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 174 NWYFFTLYGGAITGTTAIVYAQDNASWKLGFGLCVAANLISFIIFVAGKRLYEHDQPLGSpytslvrvlvaatmkrkavi 253
Cdd:cd17413 161 NRFFFCISVGSLLAVTVLVYIQDNVGRGWGYGICAAAMVLAIVVFLAGTKRYRFKKSIGS-------------------- 220
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 254 sykdedyhhreleketktyvampsksfrflnraalktegdsnnnmwrlcsvQEVEDFKAVLRLVPLW-TSVMFLSapLAV 332
Cdd:cd17413 221 ---------------------------------------------------TQVEEVKMVVRMLPIWaTTILFWT--VYA 247
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 333 QM-SMTVLQAMVMDRKLGpHFKVSAGSMQVIALVSGCVFIILNNWTTYPMYQKLIRKP--LTPLQKVGIGHVLTILSMAI 409
Cdd:cd17413 248 QMtTFSVEQAETMDRNIG-SFEIPPASMAVFLVATILLTTAVYDRVIVPLCRKLTGHPqgLTTLQRIGVGLVFSCLAMAV 326
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 410 SAVVEAKRLKTVENSHL------MSVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRNTATSLTSVVMGISFYLSTA 483
Cdd:cd17413 327 AALVELKRLRIAHAHGKpvktvpMSVFWLVPQYFLVGAGEAFIYTGQLDFFIRESPKGMKSMSTGLFLSTLSLGFFVSSF 406
                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*....
gi 15231217 484 LIDVIQRTTK------WLPNDINHGRVDNVYLVLVIIGVSNFGYFLVCS 526
Cdd:cd17413 407 LVSIVNRVTGkshphgWLADNLNKGRLDYFYWLLAVLSALNFVIFLVFA 455
MFS_NPF4 cd17414
NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The ...
25-527 9.48e-68

NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. Members of the NPF4 subfamily have been shown to transport ABA. NPF4 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340972 [Multi-domain]  Cd Length: 456  Bit Score: 225.75  E-value: 9.48e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  25 FMLVTLLGMSITYFGWVMNLIVFLIEEFNIK-SIAAVQISNIVnGVVNMLPVVAAILADSFFGNIPVISASAFISLTGIS 103
Cdd:cd17414   6 FVLVVEALENMAYLANANNLVTYLINNMHYSlAKSANIVTNFV-GTAFLLALLGGFLSDSFLSSFKTIIIFGSIELLGLI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 104 LLTLIASLDYLRPRPCET-GSILCQSPSKLQLGILYAALALVITGTAGTRFILASAGANQYKKPKEQGR-----FFNWYF 177
Cdd:cd17414  85 LLTVQAHIPSLQPPSCNSlGDLTCKEPSGSQAAILFVGLYLVALGVGCIKPNLPSHGADQFDENDPKGRrqlssFFNWYY 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 178 FTLYGGAITGTTAIVYAQDNASWKLGFGLCVAANLISFIIFVAGKRLYehdqplgspytslvrvlvaatmkrkavisykd 257
Cdd:cd17414 165 FSFSLGALIAVTLVVWVEENKGWDWGFGVSAAVIAVGILVFVAGTPFY-------------------------------- 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 258 edyhhreleketktyvampsksfRFLnraalktegdsnnnmwrlcsvQEVEDFKAVLRLVPLWTSVMFLSAPLAVQMSMT 337
Cdd:cd17414 213 -----------------------RNK---------------------TQVEEVKIVLKMLPIFACTIILNCILAQLQTFS 248
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 338 VLQAMVMDRKLGPHFKVSAGSMQVIALVSGCVFIILNNWTTYPMYQKLI--RKPLTPLQKVGIGHVLTILSMAISAVVEA 415
Cdd:cd17414 249 VQQGSTMNRTKIGSFNIPPASLQAIPVIFMLILVPLYDHLLVPFARKITghESGITHLQRIGIGLVLSTLSMVVAALVET 328
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 416 KRLKT-VENSHL-------MSVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRNTATSLTSVVMGISFYLSTALIDV 487
Cdd:cd17414 329 KRKKVaVENGLLnskenlpISIFWIALQFLILGISDMFTAVGLLEFFYTESPSSMRSLGTALTWCSYSFGFYLSSVLVSV 408
                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*..
gi 15231217 488 IQRTTKW-------LPNDINHGRVDNVYLVLVIIGVSNFGYFLVCSW 527
Cdd:cd17414 409 VNKVTGSgghggwlLGENLNRDRLDLFYWLLCVLSTINFLNYLFWAR 455
MFS_NPF8 cd17418
NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The ...
20-530 5.00e-62

NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF8 contains the Arabidopsis dipeptide transporters AtNPF8.1 (PTR1), AtNPF8.2 (PTR5), and AtNPF8.3 (PTR2), as well as tonoplast-localized transporters AtNPF8.4 (PTR4) and AtNPF8.5 (PTR6). Oryza sativa NRT1 (now called OsNPF8.9) is a low-affinity nitrate transporter. NPF8 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340976 [Multi-domain]  Cd Length: 447  Bit Score: 210.40  E-value: 5.00e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  20 WITLPFMLVTLLGMSITYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFISL 99
Cdd:cd17418   1 WKACPFILGNECCERLAYYGIATNLITYLTKELHQGNVSAANNVTNWSGTCYITPLIGAFIADAYWGRYWTIASFSAIYF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 100 TGISLLTLIASLDYLRPRPCetGSILCQSPSKLQLGILYAALALVITGTAGTRFILASAGANQYKK--PKEQGR---FFN 174
Cdd:cd17418  81 IGMVLLTLSASVPGLKPASC--IGSLCPPATSVQYAVFFLGLYLIALGTGGIKPCVSSFGADQFDDtdPKEKVRkssFFN 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 175 WYFFTLYGGAITGTTAIVYAQDNASWKLGFGLCVAANLISFIIFVAGKRLYehdqplgspytslvrvlvaatmkrkavis 254
Cdd:cd17418 159 WFYFSINIGALISSSVLVWIQENVGWGWGFGIPTVFMGIAIVSFFFGTPLY----------------------------- 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 255 ykdedyhhRELeketktyvampsksfrflnraalktegdsnnnmwrlcsvqevedfKAVLRLVPLWTSVMFLSApLAVQM 334
Cdd:cd17418 210 --------REV---------------------------------------------KILIRLLPIWASGIVFAT-VYSQM 235
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 335 S-MTVLQAMVMDRKlGPHFKVSAGSMQVIALVSGCVFIILNNWTTYPMYQKLIRKP--LTPLQKVGIGHVLTILSMAISA 411
Cdd:cd17418 236 StMFVQQGRTMDRM-GGNFEIPPASLSLFDTLSVLIWVPIYDRFIVPLVRKFTGHErgFTQLQRMGIGLFISVLSMVAAA 314
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 412 VVEAKRLKTVENSHL--------MSVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRN--TATSLTSVVMGisFYLS 481
Cdd:cd17418 315 IVEIVRLQLARTHNLvesgppvpMSIFWQIPQYFLIGAAEVFTFIGQLEFFYDQSPDAMRSlcSALSLLTTALG--NYLS 392
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15231217 482 TALIDVIQRTTK------WLPNDINHGRVDNVYLVLVIIGVSNFGYFLVCSWFYK 530
Cdd:cd17418 393 SLIVTLVTYVTTkggkpgWIPDNLNNGHLDYFFWLLASLSFLNILVYLWIAKRYT 447
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
90-496 7.07e-59

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 200.62  E-value: 7.07e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217    90 VISASAFISLTGISLLTLiASLDYLRPrpcetgsilcqspsKLQLGILYAALALVITGTAGTRFILASAGANQYKK--PK 167
Cdd:pfam00854   3 TIFLGSIIYAIGHILLAL-SAIPSLRP--------------PVHVALFFIGLALIALGTGGIKPNVSSFGGDQFEEtdPR 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217   168 EQGRFFNWYFFTLYGGAITGTTAIVYAQDNASWKLGFGLCVAANLISFIIFVAGKRLYEHDQPLGSPYTSLVRVLVAATM 247
Cdd:pfam00854  68 RRSRFFSIFYFSINAGSLISTIITPYLQQNYGYPLGFGLPAVGMIIALLVFLLGSRMYKKKPPKGNVLTKVFKVLPVAAW 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217   248 KRKAvisykdedyHHRELEKETKTYVAMPSKSFRFLNRAALKTEGDSNNNMwrlCSVQEVEDFKAVLRLVPLWTSVMFLS 327
Cdd:pfam00854 148 NKVK---------LNGSSAGIKKLHWLDWARELDALIILGIVVPGIFFNIW---CTKTKVEEVKRLLRVLPLFLPLIMFW 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217   328 APLAVQMSMTVLQAMVMDRKLGpHFKVSAGSMQVIALVSGCVFIILNNWTTYPMYQKLiRKPLTPLQKVGIGHVLTILSM 407
Cdd:pfam00854 216 ALYDQMGTSWVLQARTMNRKIG-SFEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRKC-TGGLTPLQKMAVGLFLASLAF 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217   408 AISAVVEAKRLKTV-----ENSHLMSVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRNTATSLTSVVMGISFYLST 482
Cdd:pfam00854 294 AIAAIVQLKRNDTGpefpiAQEVPISVLWLIPQYLLIGFGELFISIGGLEFFYKLAPKSMTSLITGLFLLTNALGNFLSG 373
                         410
                  ....*....|....
gi 15231217   483 ALIDVIQRTTKWLP 496
Cdd:pfam00854 374 VIATLTAKPTNVLG 387
MFS_POT cd06175
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of ...
36-526 4.55e-42

Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of transporters; The Proton-coupled oligopeptide transporter (POT) family is present across all major kingdoms of life and is known by a variety of names. It is referred to as the Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) in plants, and in addition to POT, it is also known as the Peptide transporter (PepT/PTR) or Solute Carrier 15 (SLC15) family in animals. Members of this family are proton-driven symporters involved in nitrogen acquisition in the form of di- and tripeptides. Plant members transport other nitrogenous ligands including nitrate, the plant hormone auxin, and glucosinolate compounds that are important for seed defense. POT proteins exhibit substrate multispecificity, with one transporter able to recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. The POT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340865 [Multi-domain]  Cd Length: 422  Bit Score: 156.06  E-value: 4.55e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  36 TYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFISLTGISLLTLIASLDYLR 115
Cdd:cd06175  14 TFYGIGANLVPFLTGALGLGNAQAANVVLNFLGTSYVTPLFGGWIADTFLGRYRTILIGAAIYAVGVAILTVSTIPPGLR 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 116 PRPCETGSilCQSPSKLQLGILYAALALVITGTAGTRFILASAGANQYKK--PKEQGRFFNWYFFTLYGGAITGTTAIVY 193
Cdd:cd06175  94 PLRCNPSH--CEQASGIQLTGFYAALYLIALGTGGVKANVSPLGADQFDErgPSKTQSFFNWFYFCINVGSLLAMLGTPY 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 194 AQDNASWKLGFGLCVAANLISFIIFvagkrlyehdqplgspytslvrvlvaatmkrkavisykdedyhhreleketktyv 273
Cdd:cd06175 172 IQDNVGWAAAYGIPFVAILLALVVF------------------------------------------------------- 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 274 ampsksfrflnraalktegdsnnnmwrlcsvqeveDFKAVLRLVPLWTSVMFLSAPLAVQMSMTVLQAMVMDRKLGPHfK 353
Cdd:cd06175 197 -----------------------------------EVKQLLRALPLFAFCILFWTVYAQMTTSYVLQALTLVRSTGLF-T 240
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 354 VSAGSMQVIALVSGCVFIILNNWTTYPMYqKLIRKPLTPLQKVGIGHVLTILSMAISAVVEAKRLKT--VENSHL----M 427
Cdd:cd06175 241 IPPASMQAFNPILLLLLIPVLDKVVYPLI-RRYGVGLSPLTKIGLGFFFGSLSMFVAGFLELKRLNTahAHGPVVttspL 319
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 428 SVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRNTATSLTSVVMGISFYLSTALIDVIQRTT--KWLPNDINHGRVD 505
Cdd:cd06175 320 SFWWQIPQYLLLGIGEILVSITGLEFAYREAPKSMKGFIMGLLLLTSGFGSFFGSVLVTLVSKPTdgAHIADDLNKGVLT 399
                       490       500
                ....*....|....*....|.
gi 15231217 506 NVYLVLVIIGVSNFGYFLVCS 526
Cdd:cd06175 400 NFFFLLAVLAALNFLIFLLVS 420
MFS_SLC15A1_2_like cd17347
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ...
24-533 1.04e-24

Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340905 [Multi-domain]  Cd Length: 427  Bit Score: 106.55  E-value: 1.04e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  24 PFMLVTLLGMSITYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFISLTGIS 103
Cdd:cd17347   5 PFIVGNEFCERFSYYGMRAILVLYLTDFLGFSEAEATAIYHSFVMLCYFFPLLGAIIADSYLGKYRTILYLSLVYCLGHI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 104 LLTLIASldylrPRPCETGSILcqspsklqlgiLYAALALVITGTAGTRFILASAGANQYKKP--KEQGRFFNWYFFTLY 181
Cdd:cd17347  85 VLAVTAI-----PPLGPPHVWG-----------LLIGLLLIAIGTGGIKPCVSAFGGDQFGADqqHLLARFFSWFYFAIN 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 182 GGAITGT--TAIVYAQ----DNASWKLGFGLCVAANLISFIIFVAGKRLYEhdqplgspytslvrvlvaatmkrkavisy 255
Cdd:cd17347 149 AGSLLSTflTPILRADvqfgGHDCYPLAFGVPGVLMAVATLVFWLGRKHYK----------------------------- 199
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 256 kdedyhhreleketktyvampsksfrflnraalktegdsnnnmwrlcsvqeveDFKAVLRLVPLWTSVMFLSAPLAVQMS 335
Cdd:cd17347 200 -----------------------------------------------------DVKALLRVLVLFIPLPVFWALFDQQGS 226
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 336 MTVLQAMVMDRkLGPHFKVSAGSMQVIALVSGCVFIILNNWTTYPmyqkLIRK---PLTPLQKVGIGHVLTILSMAISAV 412
Cdd:cd17347 227 RWTLQAEQMDG-LVGGFTILPDQMQALNPILILILIPLFDYVIYP----LLERcgiPLTPLRKMGVGMILAALAFVIAGF 301
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 413 VEAK--------------RLKTVENSHLMSVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRntatsltSVVMGiSF 478
Cdd:cd17347 302 LQLRidgglpgqpdpgevTTFEDIEPNSVSILWQLPQYVVLTAGEVLFSITGLEFAYTQAPKSMK-------SVVQA-AW 373
                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15231217 479 YLSTALIDVIQRTTKWLpndINHGRVDNVYLVLVIIGVSNFGYFLVCSWFYKYRN 533
Cdd:cd17347 374 LLTVALGNLIVVIVAEL---IQFSSQAAEYFFFAGLMLVVAVVFALLARFYKYVT 425
2A1704 TIGR00926
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ...
36-422 4.40e-15

Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273343 [Multi-domain]  Cd Length: 654  Bit Score: 78.26  E-value: 4.40e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217    36 TYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISasaFISLTGISLLTLIAsldylr 115
Cdd:TIGR00926   2 SYYGMRTILVLYFLNFLGFSESTSTVLFHTFTYLCYLTPLIGAIIADGWLGKFKTIL---YLSIVYVVGHALLS------ 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217   116 prpceTGSI-LCQSPSKLQLGILyaALALVITGTAGTRFILASAGANQYKKPKEQGRFFNWYFFTLYGGA----ITGTTA 190
Cdd:TIGR00926  73 -----FGAIpSSGHPLHDLLDLL--GLALIALGTGGIKPCVSAFGGDQFEERQLSLRSRFFSFFYFAINAgsliSTIITP 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217   191 IVYAQ-----DNASWKLGFGLCVAANLISFIIFVAGKRLYEHDQPLGSPYTSLVRVLVAATMKRKAVISyKDEDYHHREL 265
Cdd:TIGR00926 146 ILRGDvgcfgCQDCYPLAFGVPAILMILALIVFMAGSKMYKKKPPKGNIVSKVIKCIVTALRKRFSTRS-EHWPLHWLDY 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217   266 EKETKtyvampsksfrflnraalktegdsnnnmwrlcSVQEVEDFKAVLRLVPLWTSVMFLSAPLAVQMSMTVLQAMVMD 345
Cdd:TIGR00926 225 AKDKH--------------------------------DIRMIRSTKRLLRVLVLFIPLPMFWALFDQQGSRWTLQATRMD 272
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15231217   346 RKLGpHFKVSAGSMQVIALVsgcVFIILNNWTTYPMYQKL--IRKPLTPLQKVGIGHVLTILSMAISAVVEAKRLKTVE 422
Cdd:TIGR00926 273 GDVG-GFEIQPDQMQVVNPL---LILIFVPIFDYIVYPAIakCGTRFTSLRKMAVGGLLAALSFFVAALVQLKVNPTLP 347
MFS_SLC15A3_4 cd17348
Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; ...
35-481 3.28e-14

Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 members 3 (SLC15A3) and 4 (SLC15A4) are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They are peptide/histidine transporters (PHTs) that transport free histidine in addition to di/tripeptides. SLC15A4, also called peptide transporter 4 or peptide/histidine transporter 1 (PHT1), is expressed in the human brain, retina, placenta, and immune cells. It is required for Toll-like receptor 7 (TLR7)- and TLR9-mediated type I interferon production in plasmacytoid dendritic cells (pDCs) and is involved in the pathogenesis of lupus-like autoimmunity. SLC15A3, also called osteoclast transporter, peptide transporter 3, or peptide/histidine transporter 2 (PHT2), is expressed in immune tissues including the spleen and thymus. The SLC15A3/SLC15A4 group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340906 [Multi-domain]  Cd Length: 435  Bit Score: 74.83  E-value: 3.28e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  35 ITYFGWVMNLIVFL-IEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFISLTGISLLTLIASldy 113
Cdd:cd17348  16 AAFYGITSNLVLFLnGSPFNWEGTQASQALLLFMGATYLLSPFGGWLADAYLGRFWTILLSLLLYLLGMLLFPATAA--- 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 114 lrprpcetgsilcqspsklqlGILYAALALVITGTAGTRFILASAGANQYKK--PKEQGRFFNWYFFTLYGGAITGTTAI 191
Cdd:cd17348  93 ---------------------PALYAGLLLVGLGVGSVKANITPFGADQVKDrgPEATRRFFNWFYWSINLGAILSLGGV 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 192 VYAQDNASWKLGFGLCVAANLISFIIFVAGkrlyehdQPLGSPYTSLVRVLvaatmkrkavisykdedyhhreleketkt 271
Cdd:cd17348 152 AYIQQNVSFLIGYSIPAVCVGLAFLVFLCG-------QPVFIDVKALVKIL----------------------------- 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 272 yvampsksfrflnraalktegdsnnnmwrlcsvqevedfKAVLRLVPLWTsVMFlsaplavQMSMT-VLQAMvmdrklgp 350
Cdd:cd17348 196 ---------------------------------------PVFLALIPYWT-VYF-------QMQTTyVLQSL-------- 220
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 351 HFKVSAGSMQVIALVSGCVFIILNNWTTY----------PMYQKLI-----RKPLTP--LQKVGIGHVLTILSMAISAVV 413
Cdd:cd17348 221 HLKIPNIFISNIAGITNSSHTFPAAWLTMfdavlililiPLKDKLVdpflkRRGLLPssLKRIAVGMFFVMCSAIAAGIL 300
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 414 EAKRLKTVENSHL--------------MSVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRntatsltSVVMGISFY 479
Cdd:cd17348 301 ESKRLEIVKHNTTiqqqignvtyyaadLPIWWQIPQYLLIGISEIFASIAGLEFAYSAAPKSMQ-------SAIMGLFFF 373

                ..
gi 15231217 480 LS 481
Cdd:cd17348 374 FS 375
MFS_SLC15A5 cd17349
Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute ...
36-527 2.85e-13

Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 5 (SLC15A5) is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. The specific function of SLC15A5 is unknown. SLC15A5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340907 [Multi-domain]  Cd Length: 437  Bit Score: 71.71  E-value: 2.85e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  36 TYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFISLTGISLLTLIA--SLDY 113
Cdd:cd17349  17 TFFGIVCNMILFCTIKLGYRNHQAAIVNLCFVGTSTLTPVFVGWLAEECMGRNKLVYICLFLHFLGTALLPVVAfpFEDF 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 114 LRprpcETGSILCQSPSKLQLGILYAALALVITGTAGTRFILA--SAGANQYKKPKEQGRFFNWYFFTLYGGAITGTTAI 191
Cdd:cd17349  97 YI----DTHHIIHTLAKREQTLLFYVALLTASLGTGGIRAIVCplSAYGLQDYGSRKLMSFFNWFYWLVNLNSAVVFVGI 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 192 VYAQDNASWKLGFglcvaanLIsfiifvagkrlyehdqplgsPYTSLVRVLVAATMKRKAVISykdedyhhrelekeTKT 271
Cdd:cd17349 173 SYIQQSVAKNLGF-------LI--------------------PFMSVLMALITLHMVRNDLIN--------------TKN 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 272 YVAM-PSKSFRFLnraalktegdsnnnmWRLCSVQevedfkavlrlVPlwtsvmflsaplavqmSMTVLQAMVMDRKLGp 350
Cdd:cd17349 212 LVRLfPLFAFQIL---------------YRTCIMQ-----------IP----------------SGYYLQTMNSNLNLG- 248
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 351 HFKVSAGSMQVIALVSGCVFIILNNWTTYPMYQKLiRKPLTPLQKVGIGHVLTILSMAISAVVEA--KRLKTVENSHL-- 426
Cdd:cd17349 249 GFLLPIAAMNVISIIPLLILAPFLEYFSSCLFSSK-RYGPFLSACIIAGHLCAALSVMVAGFSEIhrKRFPLVEQTLSgk 327
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 427 ------MSVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLRNTATSLTSVVMGISFYLSTALIDVIQRTTK--WLPND 498
Cdd:cd17349 328 vllvssMPCFQLAPQYVLLGVAEALVTPACSLITFRLVPSSIRGISMHFLTLFNGAGCFMGALLIQLVYLISEgnWFPNT 407
                       490       500
                ....*....|....*....|....*....
gi 15231217 499 INHGRVDNVYLVLVIIGVSNFGYFLVCSW 527
Cdd:cd17349 408 LNKGNLERFFFFLASLMLLNALGFWRISH 436
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
68-484 1.00e-12

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 70.23  E-value: 1.00e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  68 GVVNMLPVVAAILADSFFGNIPVISASAFISLTGISLLTLIASLdylrprpcetgsilcqspsklqlGILYAALALVITG 147
Cdd:COG3104  66 ALVYLTPLLGGWLADRLLGQRRAILLGGILMALGHFLLALPGGV-----------------------TLFYLGLALIAVG 122
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 148 TAgtrFILASAGA---NQYkkPKEQGRF---FNWYFFTLYGGAITGTTAIVYAQDNASWKLGFGLCVAANLISFIIFVAG 221
Cdd:COG3104 123 NG---LFKPNISSlvgQLY--DPGDPRRdagFTIFYMGINIGAFLAPLLCGYLGEKYGWHYGFGAAAIGMLIGLIIFLLG 197
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 222 KRLYEH-----DQPLGSPYTSLVRVLVAATMKRKAVISYKDEDYHHrelekeTKTYVAMPSKSFRFLNRAALKTegdsnn 296
Cdd:COG3104 198 RKYLGDiglepDNPLSKKERLIAVALGALLLVLVLAGLLSNANIAN------YLLYVIAIIAYFIFILRSKKLT------ 265
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 297 nmwrlcsvqeVEDFKAVLRLVPLW-TSVMFLSapLAVQMSMTV-LQAM-VMDRKLGPhFKVSAGSMQVIalvsGCVFII- 372
Cdd:COG3104 266 ----------KEERKRLLAILILFlFSIVFWA--LYEQAGTSLnLFADrNVDRSLFG-FEIPPSWFQSL----NPLFIIi 328
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 373 ---LNNWttypMYQKLIRKPLTP--LQKVGIGHVLTILSMAISAVVEakrlKTVENSHLMSVLWLVPALVINGIGEAFHF 447
Cdd:COG3104 329 lapVFAA----LWTKLGKRGKEPstPTKFALGLLLLGLGFLVMALAA----LLAGAGGKVSPLWLVLAYLLLTIGELCLS 400
                       410       420       430
                ....*....|....*....|....*....|....*..
gi 15231217 448 PANIAIFYGEFPEslrntatSLTSVVMGIsFYLSTAL 484
Cdd:COG3104 401 PVGLSMITKLAPA-------RFAGQMMGL-WFLATAL 429
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
44-225 9.21e-07

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 51.42  E-value: 9.21e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  44 LIVFLIEEFN--IKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFISLTGISLLTLiasldylrprpcet 121
Cdd:cd17346  25 LILYLTAQLGdgFSEADAASIYGAYTALVYLTPIIGGWLADKVLGARRTVFIGGILMALGYLLLAL-------------- 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 122 gsilcqspSKLQLGILYAALALVITGTAgtrfILASAGANQYKK--PKEQGRF---FNWYFFTLYGGAITGTTAIVYAQD 196
Cdd:cd17346  91 --------SPFSVSMLYLGLALIIVGNG----LFKPNISSLVGKlyDENDPRRdsgFSIFYMGINLGAFLAPLLCGTLGD 158
                       170       180
                ....*....|....*....|....*....
gi 15231217 197 NASWKLGFGLCVAANLISFIIFVAGKRLY 225
Cdd:cd17346 159 NYGYHYGFGLAAVGMLLGLLIFLLGRKKL 187
MFS_SLC15A1 cd17412
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute ...
74-227 2.13e-06

Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 1 (SLC15A1), also called peptide transporter 1 (PepT1), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A1, as well as SLC15A2, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1 is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. It is a high-capacity/low-affinity transporter that drives the transport of di-and tripeptides for metabolic purposes. It's expression is upregulated in the colon during chronic inflammation associated with inflammatory bowel disease. SLC15A1/PepT1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340970 [Multi-domain]  Cd Length: 415  Bit Score: 50.23  E-value: 2.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  74 PVVAAILADSFFGNIPVISASAFISLTGISLLTLIASLDYlrprpceTGSILCQSPSKLQLGILYAA--LALVITGTAGT 151
Cdd:cd17412  55 PILGAIIADSWLGKFKTIVYLSIVYTIGQAVMAVSAIHDL-------TDANRDGTPDNLTLHVALSMigLLLIALGTGGI 127
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 152 RFILASAGANQYK--KPKEQGRFFNWYFFTLYGGAITGT--TAIVYAQD------NASWKLGFGLCVAANLISFIIFVAG 221
Cdd:cd17412 128 KPCVAAFGGDQFEehQEKQRSRFFSIFYLSINAGSLLSTiiTPILRSQEcgihskQKCYPLAFGVPAALMVVALIVFILG 207

                ....*.
gi 15231217 222 KRLYEH 227
Cdd:cd17412 208 SKMYKQ 213
PRK15462 PRK15462
dipeptide permease;
36-227 2.30e-05

dipeptide permease;


Pssm-ID: 237971 [Multi-domain]  Cd Length: 493  Bit Score: 46.87  E-value: 2.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217   36 TYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFisLTGISLLTLIASldylr 115
Cdd:PRK15462  24 SFYGMRALLILYLTNQLKYDDNHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVMLGAL--LMAIGHVVLGAS----- 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  116 prpcetgsilcqspsKLQLGILYAALALVITGTAGTRFILASAGANQYK--KPKEQGRFFnwyffTLYG----GAITGTT 189
Cdd:PRK15462  97 ---------------EIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYEptDPRRDGGFS-----LMYAagnvGSIIAPI 156
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 15231217  190 AIVYAQDNASWKLGFGLCVAANLISFIIFVAGKRLYEH 227
Cdd:PRK15462 157 ACGYAQEEYSWAMGFGLAAVGMIAGLVIFLCGNRHFTH 194
MFS_SLC15A2 cd17411
Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute ...
21-463 1.02e-04

Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 2 (SLC15A2), also called peptide transporter 2 (PepT2), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A2, as well as SLC15A1, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A2 is a high-affinity transporter and is abundantly expressed in the apical membrane of kidney proximal tubules and choroid plexus epithelial cells. It is the major transporter involved in the reclamation of peptide-bound amino acids and peptide-like drugs in the kidney, and is also called the renal isoform. In choroid plexus and the brain, it acts as an efflux transporter and plays a role in regulating peptide/neuropeptide homeostasis. SLC15A2/PepT2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340969 [Multi-domain]  Cd Length: 403  Bit Score: 44.82  E-value: 1.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  21 ITLPFMLVTLLGMSITYFGWVMNLIVFLIEEFNIKSIAAVQISNIVNGVVNMLPVVAAILADSFFGNIPVISASAFISLT 100
Cdd:cd17411   2 LSIAFIVVNEFCERFSYYGMKAVLTLYFLSFLHWDENLSTAIYHAFSGLCYFTPVLGALIADSWLGKFKTIIYLSIVYVV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 101 GisllTLIASLdylrprpcetGSILCQSPSKLQLGILYAALALVITGTAGTRFILASAGANQY--KKPKEQGRFFNWYFF 178
Cdd:cd17411  82 G----HVIKSV----------GAIPTVGDQQVHVVLSMIGLFLIALGTGGIKPCVAAFGGDQFeeEHARERSKFFSIFYL 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 179 TLYGGAITGT--TAIVYAQ----DNASWKLGFGLCVAANLISFIIFVAGKRLYehdqplgspytslvrvlvaatmkrkav 252
Cdd:cd17411 148 SINAGSLISTfvTPILRGDvqcfGGDCYALAFGVPAALMVVALVVFIAGSGMY--------------------------- 200
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 253 isykdedyhhreleketktyvampsksfrflnraalktegdsnnnmwrlcsvqevEDFKAVLRLVPLWTSVMFLSAPLAV 332
Cdd:cd17411 201 -------------------------------------------------------KEVKMVTRVLFLYIPLPMFWALFDQ 225
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217 333 QMSMTVLQAMVMDRKLGpHFKVSAGSMQVIALVSGCVFIILNNWTTYPMYQKlIRKPLTPLQKVGIGHVLTILSMAISAV 412
Cdd:cd17411 226 QGSRWTLQATRMNDFGG-GFVLQPDQMQTLNPLLILVFIPIFDLGIYPLVSK-CKINFTSLRKMATGMILAALAFAVAAA 303
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
gi 15231217 413 VEAKrlktvenshlmsVLWLVPALVINGIGEAFHFPANIAIFYGEFPESLR 463
Cdd:cd17411 304 VEIK------------IAWQLPQYVLLSAGEVMFSITGLEFSYSQAPASMK 342
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
18-223 4.90e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.55  E-value: 4.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  18 GGWITLPFMLVTLLGMSITYFGWVM-------NLIVFLIEEFNIkSIAAVQISNIVNGVVNML-PVVAAILADSFF-GNI 88
Cdd:COG2271 170 LGLPGLLLALLRFWLLALAYFLVYFalygfltWLPTYLVEVRGL-SLAQAGLLLSLPFLAGIVgSLLGGWLSDRLGrRRK 248
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15231217  89 PVISASAFISLTGISLLTLIASldylrprpcetgsilcqspsklqLGILYAALALVITGTAGTRFILASAGANQYkKPKE 168
Cdd:COG2271 249 LVLAIGLLLAALALLLLALLPS-----------------------PALAIALLFLAGFGLGGAFGLLWALAAELF-PKKA 304
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 15231217 169 QGRFFNWYFFTLYGGAITGTTAIVYAQDNASWKLGFGLCVAANLISFIIFVAGKR 223
Cdd:COG2271 305 RGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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