uncharacterized protein AT3G45500 [Arabidopsis thaliana]
Protein Classification
ribonuclease H family protein( domain architecture ID 54171)
ribonuclease H (RNase H) family protein may function as an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| RNase_H_like super family | cl14782 | Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of ... |
23-87 | 3.58e-06 | ||
Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8; Ribonuclease H (RNase H) enzymes are divided into two major families, Type 1 and Type 2, based on amino acid sequence similarities and biochemical properties. RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner in the presence of divalent cations. It is widely present in various organisms, including bacteria, archaea, and eukaryotes. Most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site residues and have the same catalytic mechanism and functions in cells. RNase H is involved in DNA replication, repair and transcription. An important RNase H function is to remove Okazaki fragments during DNA replication. RNase H inhibitors have been explored as anti-HIV drug targets since RNase H inactivation inhibits reverse transcription. This model also includes the Prp8 domain IV, which adopts the RNase fold but shows low sequence homology; domain IV is implicated in key spliceosomal interactions. The actual alignment was detected with superfamily member pfam13456: Pssm-ID: 449355 [Multi-domain] Cd Length: 123 Bit Score: 44.56 E-value: 3.58e-06
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| Name | Accession | Description | Interval | E-value | ||
| RVT_3 | pfam13456 | Reverse transcriptase-like; This domain is found in plants and appears to be part of a ... |
23-87 | 3.58e-06 | ||
Reverse transcriptase-like; This domain is found in plants and appears to be part of a retrotransposon. Pssm-ID: 433223 [Multi-domain] Cd Length: 123 Bit Score: 44.56 E-value: 3.58e-06
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| Name | Accession | Description | Interval | E-value | ||
| RVT_3 | pfam13456 | Reverse transcriptase-like; This domain is found in plants and appears to be part of a ... |
23-87 | 3.58e-06 | ||
Reverse transcriptase-like; This domain is found in plants and appears to be part of a retrotransposon. Pssm-ID: 433223 [Multi-domain] Cd Length: 123 Bit Score: 44.56 E-value: 3.58e-06
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