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Conserved domains on  [gi|30689857|ref|NP_189653|]
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nodulin MtN21 /EamA-like transporter family protein [Arabidopsis thaliana]

Protein Classification

DMT family transporter( domain architecture ID 706274)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others; similar to Arabidopsis thaliana protein WALLS ARE THIN 1 (WAT1) and WAT1-related proteins

Gene Ontology:  GO:0016020|GO:0022857
PubMed:  11432728
TCDB:  2.A.7

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN00411 super family cl28283
nodulin MtN21 family protein; Provisional
8-346 1.33e-44

nodulin MtN21 family protein; Provisional


The actual alignment was detected with superfamily member PLN00411:

Pssm-ID: 177805 [Multi-domain]  Cd Length: 358  Bit Score: 157.04  E-value: 1.33e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857    8 LWK--AVLMMSMINIGLSVVNV--MFKKMIDEGLNRMVATTYRLAVGTLFLIPFAIFLERHNR-PKLTGRILCSLFFSAL 82
Cdd:PLN00411   7 LWRreAVFLTAMLATETSVVGIstLFKVATSKGLNIYPFLGYSYLLASLLLLPSLFFTNRSRSlPPLSVSILSKIGLLGF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857   83 LGTSLVQYFFlIGLEYTSSTFSLAFSNMVPSVTFALALVFRQETLNIKSNVGRAKLLGTMICICGALVLTLYKGTALSRE 162
Cdd:PLN00411  87 LGSMYVITGY-IGIEYSNPTLASAISNITPALTFILAIIFRMEKVSFKERSSVAKVMGTILSLIGALVVIFYHGPRVFVA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857  163 HS-THMETHTRTDSTGAMTQKWAMGSIMLVISIIIWSSWFIVQAKISRVYPCQYTSTTILSFFGVIQSALLSLISERST- 240
Cdd:PLN00411 166 SSpPYLNFRQLSPPLSSSNSDWLIGGALLTIQGIFVSVSFILQAHIMSEYPAAFTVSFLYTVCVSIVTSMIGLVVEKNNp 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857  241 SMWVVKDKFQVLALLYSGIVGSgLCYVGMSWCLRQRGAVFTSSFIPLIQVFAAIFSFSFLHEQIYCGSVIGSMVIIVGLY 320
Cdd:PLN00411 246 SVWIIHFDITLITIVTMAIITS-VYYVIHSWTVRHKGPLYLAIFKPLSILIAVVMGAIFLNDSLYLGCLIGGILITLGFY 324
                        330       340
                 ....*....|....*....|....*....
gi 30689857  321 ILLWGKS---KDKSASVTKQEPLDLDIEG 346
Cdd:PLN00411 325 AVMWGKAneeKDQLLSFSGKEKTPLLLNG 353
 
Name Accession Description Interval E-value
PLN00411 PLN00411
nodulin MtN21 family protein; Provisional
8-346 1.33e-44

nodulin MtN21 family protein; Provisional


Pssm-ID: 177805 [Multi-domain]  Cd Length: 358  Bit Score: 157.04  E-value: 1.33e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857    8 LWK--AVLMMSMINIGLSVVNV--MFKKMIDEGLNRMVATTYRLAVGTLFLIPFAIFLERHNR-PKLTGRILCSLFFSAL 82
Cdd:PLN00411   7 LWRreAVFLTAMLATETSVVGIstLFKVATSKGLNIYPFLGYSYLLASLLLLPSLFFTNRSRSlPPLSVSILSKIGLLGF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857   83 LGTSLVQYFFlIGLEYTSSTFSLAFSNMVPSVTFALALVFRQETLNIKSNVGRAKLLGTMICICGALVLTLYKGTALSRE 162
Cdd:PLN00411  87 LGSMYVITGY-IGIEYSNPTLASAISNITPALTFILAIIFRMEKVSFKERSSVAKVMGTILSLIGALVVIFYHGPRVFVA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857  163 HS-THMETHTRTDSTGAMTQKWAMGSIMLVISIIIWSSWFIVQAKISRVYPCQYTSTTILSFFGVIQSALLSLISERST- 240
Cdd:PLN00411 166 SSpPYLNFRQLSPPLSSSNSDWLIGGALLTIQGIFVSVSFILQAHIMSEYPAAFTVSFLYTVCVSIVTSMIGLVVEKNNp 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857  241 SMWVVKDKFQVLALLYSGIVGSgLCYVGMSWCLRQRGAVFTSSFIPLIQVFAAIFSFSFLHEQIYCGSVIGSMVIIVGLY 320
Cdd:PLN00411 246 SVWIIHFDITLITIVTMAIITS-VYYVIHSWTVRHKGPLYLAIFKPLSILIAVVMGAIFLNDSLYLGCLIGGILITLGFY 324
                        330       340
                 ....*....|....*....|....*....
gi 30689857  321 ILLWGKS---KDKSASVTKQEPLDLDIEG 346
Cdd:PLN00411 325 AVMWGKAneeKDQLLSFSGKEKTPLLLNG 353
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
31-328 1.98e-23

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 98.38  E-value: 1.98e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857  31 KMIDEGLNRMVATTYRLAVGTLFLIPFAIFLERHNRPkLTGRILCSLFFSALLGTSLVQYFFLIGLEYTSSTFSLAFSNM 110
Cdd:COG0697  23 KLALAGLPPLQLAFLRFLLAALLLLPLLLLRGRRLPP-LSRRDWLLLLLRGLLGLALAFLLFFLALQYTPAALAALLLAL 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857 111 VPSVTFALALVFRQETlniksnVGRAKLLGTMICICGALVLTLykgtalsrehsthmethtrtdSTGAMTQKWAMGSIML 190
Cdd:COG0697 102 APLFVALLAALLLGER------LSRRRWLGLLLGFAGVLLIVG---------------------PGGGGGGGSLLGDLLA 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857 191 VISIIIWSSWFIVQAKISRVYPcQYTSTTILSFFGVIQSALLSLISERSTSMWVVkdkfQVLALLYSGIVGSGLCYVGMS 270
Cdd:COG0697 155 LLAALSWALYTVLTRRLSRRLD-PLTLTFWQMLVGALLLLPLALLTGLPLPLSAA----AWLALLYLGLFGTALAYLLWF 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 30689857 271 WCLRQRGAVFTSSFIPLIQVFAAIFSFSFLHEQIYCGSVIGSMVIIVGLYILLWGKSK 328
Cdd:COG0697 230 RALRRLGASRAAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLAALRERR 287
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
185-324 6.67e-10

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 56.82  E-value: 6.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857   185 MGSIMLVISIIIWSSWFIVQAKISRVYPcQYTSTTILSFFGVIQSALLSLISERSTSMwvvkDKFQVLALLYSGIVGSGL 264
Cdd:pfam00892   2 KGILLALLAALIWAIYFVFSKILLRRIS-PLTLTFWRFLIAGILLLPFALFTGGKLVI----PLKSWLALLYLGVLGTFL 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857   265 CYVGMSWCLRQRGAVFTSSFIPLIQVFAAIFSFSFLHEQIYCGSVIGSMVIIVGLYILLW 324
Cdd:pfam00892  77 GFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
 
Name Accession Description Interval E-value
PLN00411 PLN00411
nodulin MtN21 family protein; Provisional
8-346 1.33e-44

nodulin MtN21 family protein; Provisional


Pssm-ID: 177805 [Multi-domain]  Cd Length: 358  Bit Score: 157.04  E-value: 1.33e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857    8 LWK--AVLMMSMINIGLSVVNV--MFKKMIDEGLNRMVATTYRLAVGTLFLIPFAIFLERHNR-PKLTGRILCSLFFSAL 82
Cdd:PLN00411   7 LWRreAVFLTAMLATETSVVGIstLFKVATSKGLNIYPFLGYSYLLASLLLLPSLFFTNRSRSlPPLSVSILSKIGLLGF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857   83 LGTSLVQYFFlIGLEYTSSTFSLAFSNMVPSVTFALALVFRQETLNIKSNVGRAKLLGTMICICGALVLTLYKGTALSRE 162
Cdd:PLN00411  87 LGSMYVITGY-IGIEYSNPTLASAISNITPALTFILAIIFRMEKVSFKERSSVAKVMGTILSLIGALVVIFYHGPRVFVA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857  163 HS-THMETHTRTDSTGAMTQKWAMGSIMLVISIIIWSSWFIVQAKISRVYPCQYTSTTILSFFGVIQSALLSLISERST- 240
Cdd:PLN00411 166 SSpPYLNFRQLSPPLSSSNSDWLIGGALLTIQGIFVSVSFILQAHIMSEYPAAFTVSFLYTVCVSIVTSMIGLVVEKNNp 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857  241 SMWVVKDKFQVLALLYSGIVGSgLCYVGMSWCLRQRGAVFTSSFIPLIQVFAAIFSFSFLHEQIYCGSVIGSMVIIVGLY 320
Cdd:PLN00411 246 SVWIIHFDITLITIVTMAIITS-VYYVIHSWTVRHKGPLYLAIFKPLSILIAVVMGAIFLNDSLYLGCLIGGILITLGFY 324
                        330       340
                 ....*....|....*....|....*....
gi 30689857  321 ILLWGKS---KDKSASVTKQEPLDLDIEG 346
Cdd:PLN00411 325 AVMWGKAneeKDQLLSFSGKEKTPLLLNG 353
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
31-328 1.98e-23

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 98.38  E-value: 1.98e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857  31 KMIDEGLNRMVATTYRLAVGTLFLIPFAIFLERHNRPkLTGRILCSLFFSALLGTSLVQYFFLIGLEYTSSTFSLAFSNM 110
Cdd:COG0697  23 KLALAGLPPLQLAFLRFLLAALLLLPLLLLRGRRLPP-LSRRDWLLLLLRGLLGLALAFLLFFLALQYTPAALAALLLAL 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857 111 VPSVTFALALVFRQETlniksnVGRAKLLGTMICICGALVLTLykgtalsrehsthmethtrtdSTGAMTQKWAMGSIML 190
Cdd:COG0697 102 APLFVALLAALLLGER------LSRRRWLGLLLGFAGVLLIVG---------------------PGGGGGGGSLLGDLLA 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857 191 VISIIIWSSWFIVQAKISRVYPcQYTSTTILSFFGVIQSALLSLISERSTSMWVVkdkfQVLALLYSGIVGSGLCYVGMS 270
Cdd:COG0697 155 LLAALSWALYTVLTRRLSRRLD-PLTLTFWQMLVGALLLLPLALLTGLPLPLSAA----AWLALLYLGLFGTALAYLLWF 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 30689857 271 WCLRQRGAVFTSSFIPLIQVFAAIFSFSFLHEQIYCGSVIGSMVIIVGLYILLWGKSK 328
Cdd:COG0697 230 RALRRLGASRAAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLAALRERR 287
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
185-324 6.67e-10

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 56.82  E-value: 6.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857   185 MGSIMLVISIIIWSSWFIVQAKISRVYPcQYTSTTILSFFGVIQSALLSLISERSTSMwvvkDKFQVLALLYSGIVGSGL 264
Cdd:pfam00892   2 KGILLALLAALIWAIYFVFSKILLRRIS-PLTLTFWRFLIAGILLLPFALFTGGKLVI----PLKSWLALLYLGVLGTFL 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857   265 CYVGMSWCLRQRGAVFTSSFIPLIQVFAAIFSFSFLHEQIYCGSVIGSMVIIVGLYILLW 324
Cdd:pfam00892  77 GFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
9-153 8.20e-09

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 53.35  E-value: 8.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857     9 WKAVLMMSMINIGLSVVNVMFKKMIdEGLNRMVATTYRLAVGTLFLIPFAIFLERhnRPKLTGRILCSLFFSALLGTSLV 88
Cdd:pfam00892   1 LKGILLALLAALIWAIYFVFSKILL-RRISPLTLTFWRFLIAGILLLPFALFTGG--KLVIPLKSWLALLYLGVLGTFLG 77
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30689857    89 QYFFLIGLEYTSSTFSLAFSNMVPSVTFALALVFRQETLNIKsnvgraKLLGTMICICGALVLTL 153
Cdd:pfam00892  78 FLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLK------QLLGIVLILLGVLLILL 136
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
185-333 1.28e-04

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 43.29  E-value: 1.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30689857 185 MGSIMLVISIIIWSSWFIVQAKISRVYPcqytSTTILSFFGVIQSALLSLISERSTSMWVVKDKFQVLALLYSGIVGSGL 264
Cdd:COG0697   3 RGILLLLLAALLWGSSFVAIKLALAGLP----PLQLAFLRFLLAALLLLPLLLLRGRRLPPLSRRDWLLLLLRGLLGLAL 78
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30689857 265 CYVGMSWCLRQRGAVFTSSFIPLIQVFAAIFSFSFLHEQIYCGSVIGSMVIIVGLYILLWGKSKDKSAS 333
Cdd:COG0697  79 AFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGS 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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