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Conserved domains on  [gi|42565088|ref|NP_188791|]
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transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455513)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 399-694 3.02e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 182.15  E-value: 3.02e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 399 TIEHQGHRSDVRSVTLSEDNTLLMSTSHSE-VKIWNPSTGSCLRTI---DSGYGLCSLiVPQNKYGIVGTKSGVLEIIDI 474
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGtIKVWDLETGELLRTLkghTGPVRDVAA-SADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 475 GSATKVEEVKAHGGTIWSITPIPNDSGFVTVSADHEVKFWEYQvkqkSGKATKKLTVSNvksmkmnDDVLAVAISPDAKH 554
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE----TGKCLTTLRGHT-------DWVNSVAFSPDGTF 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 555 IAVALLDSTVKVFYMDSLKFYLSLYGHKLPVMCIDISSDGELIVTGSQDKNLKIWGLDFGDCHKSIFAHGDSVMGVKFVR 634
Cdd:cd00200 150 VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 635 NTHYLFSIGKDRLVKYWDADKFEHLLTLEGHHAEIWCLAISNRGDFLVTGSHDRSMRRWD 694
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
58-612 7.52e-46

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.09  E-value: 7.52e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088  58 SSSRGGPSLAVTSIASSASSLVAVGYADGSIRIWDTEKGTCEVNFNSHKGAVTALRYNKVGSMLASGSKDNDIILWDVVG 137
Cdd:COG2319  30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 138 ESGLFRLRGHRDQVTDLVFLDGGKKLVSSSKDKFLRVWDLETQHCMQIVSGHHSEVWSVDTDPEERYVVTGSADQELRFY 217
Cdd:COG2319 110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 218 AVKeyssngslvsdsNANEIKASEEHStenkweilklfgeiqrqtkDRVARVRFNVSGKLLACQMAGKTIEIFRVldeae 297
Cdd:COG2319 190 DLA------------TGKLLRTLTGHT-------------------GAVRSVAFSPDGKLLASGSADGTVRLWDL----- 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 298 akqkakrrlrrkekksskvgdenstangeasakieladavssptvldvfkllqviRAGRKISSFsfcptapkeslgtlal 377
Cdd:COG2319 234 -------------------------------------------------------ATGKLLRTL---------------- 242

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 378 slnnnslefyslkssenaktvtiehQGHRSDVRSVTLSEDNTLLMSTSHS-EVKIWNPSTGSCLRTIDsgyglcslivpq 456
Cdd:COG2319 243 -------------------------TGHSGSVRSVAFSPDGRLLASGSADgTVRLWDLATGELLRTLT------------ 285

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 457 nkygivgtksgvleiidigsatkveevkAHGGTIWSITPIPNDSGFVTVSADHEVKFWEYQvkqkSGKATKKLTVSnvks 536
Cdd:COG2319 286 ----------------------------GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTGH---- 329

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42565088 537 mkmNDDVLAVAISPDAKHIAVALLDSTVKVFYMDSLKFYLSLYGHKLPVMCIDISSDGELIVTGSQDKNLKIWGLD 612
Cdd:COG2319 330 ---TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 795-898 2.86e-22

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


:

Pssm-ID: 461125  Cd Length: 106  Bit Score: 92.23  E-value: 2.86e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088   795 PSEYVLRA-ISNVRTNDLEQTLLALPFSDSLKFLCYMKDWSL-IPEKVELVSRIATIILQTHHNQLVTTPSARPILSVLR 872
Cdd:pfam04003   1 NDEYLLESvLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAeRSPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*.
gi 42565088   873 DILYSEIKACKDTIGFNLAAMDHVKQ 898
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNLGALDYLLS 106
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 399-694 3.02e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 182.15  E-value: 3.02e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 399 TIEHQGHRSDVRSVTLSEDNTLLMSTSHSE-VKIWNPSTGSCLRTI---DSGYGLCSLiVPQNKYGIVGTKSGVLEIIDI 474
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGtIKVWDLETGELLRTLkghTGPVRDVAA-SADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 475 GSATKVEEVKAHGGTIWSITPIPNDSGFVTVSADHEVKFWEYQvkqkSGKATKKLTVSNvksmkmnDDVLAVAISPDAKH 554
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE----TGKCLTTLRGHT-------DWVNSVAFSPDGTF 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 555 IAVALLDSTVKVFYMDSLKFYLSLYGHKLPVMCIDISSDGELIVTGSQDKNLKIWGLDFGDCHKSIFAHGDSVMGVKFVR 634
Cdd:cd00200 150 VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 635 NTHYLFSIGKDRLVKYWDADKFEHLLTLEGHHAEIWCLAISNRGDFLVTGSHDRSMRRWD 694
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
373-696 4.13e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 182.42  E-value: 4.13e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 373 GTLALSLNNNSLEFYSLKSSENAKTVTiehqGHRSDVRSVTLSEDNTLLMSTSH-SEVKIWNPSTGSCLRTID--SGYGL 449
Cdd:COG2319  91 RLLASASADGTVRLWDLATGLLLRTLT----GHTGAVRSVAFSPDGKTLASGSAdGTVRLWDLATGKLLRTLTghSGAVT 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 450 CSLIVPQNKYGIVGTKSGVLEIIDIGSATKVEEVKAHGGTIWSITPIPNDSGFVTVSADHEVKFWEYQvkqkSGKATKKL 529
Cdd:COG2319 167 SVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA----TGKLLRTL 242

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 530 TVSNvksmkmnDDVLAVAISPDAKHIAVALLDSTVKVFYMDSLKFYLSLYGHKLPVMCIDISSDGELIVTGSQDKNLKIW 609
Cdd:COG2319 243 TGHS-------GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 610 GLDFGDCHKSIFAHGDSVMGVKFVRNTHYLFSIGKDRLVKYWDADKFEHLLTLEGHHAEIWCLAISNRGDFLVTGSHDRS 689
Cdd:COG2319 316 DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395


                ....*..
gi 42565088 690 MRRWDRS 696
Cdd:COG2319 396 VRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
58-612 7.52e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.09  E-value: 7.52e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088  58 SSSRGGPSLAVTSIASSASSLVAVGYADGSIRIWDTEKGTCEVNFNSHKGAVTALRYNKVGSMLASGSKDNDIILWDVVG 137
Cdd:COG2319  30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 138 ESGLFRLRGHRDQVTDLVFLDGGKKLVSSSKDKFLRVWDLETQHCMQIVSGHHSEVWSVDTDPEERYVVTGSADQELRFY 217
Cdd:COG2319 110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 218 AVKeyssngslvsdsNANEIKASEEHStenkweilklfgeiqrqtkDRVARVRFNVSGKLLACQMAGKTIEIFRVldeae 297
Cdd:COG2319 190 DLA------------TGKLLRTLTGHT-------------------GAVRSVAFSPDGKLLASGSADGTVRLWDL----- 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 298 akqkakrrlrrkekksskvgdenstangeasakieladavssptvldvfkllqviRAGRKISSFsfcptapkeslgtlal 377
Cdd:COG2319 234 -------------------------------------------------------ATGKLLRTL---------------- 242

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 378 slnnnslefyslkssenaktvtiehQGHRSDVRSVTLSEDNTLLMSTSHS-EVKIWNPSTGSCLRTIDsgyglcslivpq 456
Cdd:COG2319 243 -------------------------TGHSGSVRSVAFSPDGRLLASGSADgTVRLWDLATGELLRTLT------------ 285

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 457 nkygivgtksgvleiidigsatkveevkAHGGTIWSITPIPNDSGFVTVSADHEVKFWEYQvkqkSGKATKKLTVSnvks 536
Cdd:COG2319 286 ----------------------------GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTGH---- 329

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42565088 537 mkmNDDVLAVAISPDAKHIAVALLDSTVKVFYMDSLKFYLSLYGHKLPVMCIDISSDGELIVTGSQDKNLKIWGLD 612
Cdd:COG2319 330 ---TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 24-218 2.22e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.09  E-value: 2.22e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088  24 IAYDSTGKYVLA-PALEKVGIWHVRQGVCSKTLTpsssrgGPSLAVTSIA-SSASSLVAVGYADGSIRIWDTEKGTCEVN 101
Cdd:cd00200  99 VAFSPDGRILSSsSRDKTIKVWDVETGKCLTTLR------GHTDWVNSVAfSPDGTFVASSSQDGTIKLWDLRTGKCVAT 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 102 FNSHKGAVTALRYNKVGSMLASGSKDNDIILWDVVGESGLFRLRGHRDQVTDLVFLDGGKKLVSSSKDKFLRVWDLETQH 181
Cdd:cd00200 173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 42565088 182 CMQIVSGHHSEVWSVDTDPEERYVVTGSADQELRFYA 218
Cdd:cd00200 253 CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 795-898 2.86e-22

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 92.23  E-value: 2.86e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088   795 PSEYVLRA-ISNVRTNDLEQTLLALPFSDSLKFLCYMKDWSL-IPEKVELVSRIATIILQTHHNQLVTTPSARPILSVLR 872
Cdd:pfam04003   1 NDEYLLESvLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAeRSPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*.
gi 42565088   873 DILYSEIKACKDTIGFNLAAMDHVKQ 898
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNLGALDYLLS 106
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 71-217 2.14e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 2.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088   71 IASSASSLVAVGYADGSIRIWDTEKGTcEVNFNSHKGAVTALRY-NKVGSMLASGSKDNDIILWDVVGES-GLFRLRGHR 148
Cdd:PLN00181 583 YSSADPTLLASGSDDGSVKLWSINQGV-SIGTIKTKANICCVQFpSESGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHS 661

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42565088  149 DQVTDLVFLDGgKKLVSSSKDKFLRVWDLE------TQHCMQIVSGHHSEVWSVDTDPEERYVVTGSADQELRFY 217
Cdd:PLN00181 662 KTVSYVRFVDS-STLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVY 735
WD40 pfam00400
WD domain, G-beta repeat;
656-694 7.99e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 7.99e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 42565088   656 FEHLLTLEGHHAEIWCLAISNRGDFLVTGSHDRSMRRWD 694
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 655-694 1.03e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 1.03e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 42565088    655 KFEHLLTLEGHHAEIWCLAISNRGDFLVTGSHDRSMRRWD 694
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 95-134 2.68e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 2.68e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 42565088     95 KGTCEVNFNSHKGAVTALRYNKVGSMLASGSKDNDIILWD 134
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
96-134 1.30e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.30e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 42565088    96 GTCEVNFNSHKGAVTALRYNKVGSMLASGSKDNDIILWD 134
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 554-696 1.88e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 1.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088  554 HIAVALLDSTVKVFYMDSLKFYLSLYGHKLPVMCIDISS-DGELIVTGSQDKNLKIWGLDFGDCHKSIFAHGDsVMGVKF 632
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQF 625

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42565088  633 VRNTHYLFSIGK-DRLVKYWDADKFE-HLLTLEGHHAEIWCLAISNRGDfLVTGSHDRSMRRWDRS 696
Cdd:PLN00181 626 PSESGRSLAFGSaDHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLS 690
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 399-694 3.02e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 182.15  E-value: 3.02e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 399 TIEHQGHRSDVRSVTLSEDNTLLMSTSHSE-VKIWNPSTGSCLRTI---DSGYGLCSLiVPQNKYGIVGTKSGVLEIIDI 474
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGtIKVWDLETGELLRTLkghTGPVRDVAA-SADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 475 GSATKVEEVKAHGGTIWSITPIPNDSGFVTVSADHEVKFWEYQvkqkSGKATKKLTVSNvksmkmnDDVLAVAISPDAKH 554
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE----TGKCLTTLRGHT-------DWVNSVAFSPDGTF 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 555 IAVALLDSTVKVFYMDSLKFYLSLYGHKLPVMCIDISSDGELIVTGSQDKNLKIWGLDFGDCHKSIFAHGDSVMGVKFVR 634
Cdd:cd00200 150 VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 635 NTHYLFSIGKDRLVKYWDADKFEHLLTLEGHHAEIWCLAISNRGDFLVTGSHDRSMRRWD 694
Cdd:cd00200 230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
373-696 4.13e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 182.42  E-value: 4.13e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 373 GTLALSLNNNSLEFYSLKSSENAKTVTiehqGHRSDVRSVTLSEDNTLLMSTSH-SEVKIWNPSTGSCLRTID--SGYGL 449
Cdd:COG2319  91 RLLASASADGTVRLWDLATGLLLRTLT----GHTGAVRSVAFSPDGKTLASGSAdGTVRLWDLATGKLLRTLTghSGAVT 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 450 CSLIVPQNKYGIVGTKSGVLEIIDIGSATKVEEVKAHGGTIWSITPIPNDSGFVTVSADHEVKFWEYQvkqkSGKATKKL 529
Cdd:COG2319 167 SVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA----TGKLLRTL 242

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 530 TVSNvksmkmnDDVLAVAISPDAKHIAVALLDSTVKVFYMDSLKFYLSLYGHKLPVMCIDISSDGELIVTGSQDKNLKIW 609
Cdd:COG2319 243 TGHS-------GSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 610 GLDFGDCHKSIFAHGDSVMGVKFVRNTHYLFSIGKDRLVKYWDADKFEHLLTLEGHHAEIWCLAISNRGDFLVTGSHDRS 689
Cdd:COG2319 316 DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT 395


                ....*..
gi 42565088 690 MRRWDRS 696
Cdd:COG2319 396 VRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
395-696 4.26e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.94  E-value: 4.26e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 395 AKTVTIEHQGHRSDVRSVTLSEDNTLLMSTSH-SEVKIWNPSTGSCLRTIDSGYGLCSLIV--PQNKYGIVGTKSGVLEI 471
Cdd:COG2319  67 AGALLATLLGHTAAVLSVAFSPDGRLLASASAdGTVRLWDLATGLLLRTLTGHTGAVRSVAfsPDGKTLASGSADGTVRL 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 472 IDIGSATKVEEVKAHGGTIWSITPIPNDSGFVTVSADHEVKFWEYQvkqkSGKATKKLTVSNvksmkmnDDVLAVAISPD 551
Cdd:COG2319 147 WDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTGHT-------GAVRSVAFSPD 215

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 552 AKHIAVALLDSTVKVFYMDSLKFYLSLYGHKLPVMCIDISSDGELIVTGSQDKNLKIWGLDFGDCHKSIFAHGDSVMGVK 631
Cdd:COG2319 216 GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA 295

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42565088 632 FVRNTHYLFSIGKDRLVKYWDADKFEHLLTLEGHHAEIWCLAISNRGDFLVTGSHDRSMRRWDRS 696
Cdd:COG2319 296 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
58-612 7.52e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.09  E-value: 7.52e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088  58 SSSRGGPSLAVTSIASSASSLVAVGYADGSIRIWDTEKGTCEVNFNSHKGAVTALRYNKVGSMLASGSKDNDIILWDVVG 137
Cdd:COG2319  30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 138 ESGLFRLRGHRDQVTDLVFLDGGKKLVSSSKDKFLRVWDLETQHCMQIVSGHHSEVWSVDTDPEERYVVTGSADQELRFY 217
Cdd:COG2319 110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 218 AVKeyssngslvsdsNANEIKASEEHStenkweilklfgeiqrqtkDRVARVRFNVSGKLLACQMAGKTIEIFRVldeae 297
Cdd:COG2319 190 DLA------------TGKLLRTLTGHT-------------------GAVRSVAFSPDGKLLASGSADGTVRLWDL----- 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 298 akqkakrrlrrkekksskvgdenstangeasakieladavssptvldvfkllqviRAGRKISSFsfcptapkeslgtlal 377
Cdd:COG2319 234 -------------------------------------------------------ATGKLLRTL---------------- 242

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 378 slnnnslefyslkssenaktvtiehQGHRSDVRSVTLSEDNTLLMSTSHS-EVKIWNPSTGSCLRTIDsgyglcslivpq 456
Cdd:COG2319 243 -------------------------TGHSGSVRSVAFSPDGRLLASGSADgTVRLWDLATGELLRTLT------------ 285

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 457 nkygivgtksgvleiidigsatkveevkAHGGTIWSITPIPNDSGFVTVSADHEVKFWEYQvkqkSGKATKKLTVSnvks 536
Cdd:COG2319 286 ----------------------------GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA----TGKLLRTLTGH---- 329

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42565088 537 mkmNDDVLAVAISPDAKHIAVALLDSTVKVFYMDSLKFYLSLYGHKLPVMCIDISSDGELIVTGSQDKNLKIWGLD 612
Cdd:COG2319 330 ---TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
24-292 1.16e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.15  E-value: 1.16e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088  24 IAYDSTGKYVLAPALEK-VGIWHVRQGVCSKTLTpsssrgGPSLAVTSIA-SSASSLVAVGYADGSIRIWDTEKGTCEVN 101
Cdd:COG2319 126 VAFSPDGKTLASGSADGtVRLWDLATGKLLRTLT------GHSGAVTSVAfSPDGKLLASGSDDGTVRLWDLATGKLLRT 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 102 FNSHKGAVTALRYNKVGSMLASGSKDNDIILWDVVGESGLFRLRGHRDQVTDLVFLDGGKKLVSSSKDKFLRVWDLETQH 181
Cdd:COG2319 200 LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE 279

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 182 CMQIVSGHHSEVWSVDTDPEERYVVTGSADQELRFYAVKE------------------YSSNGS-LVSDSNANEIKAsee 242
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATgkllrtltghtgavrsvaFSPDGKtLASGSDDGTVRL--- 356

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 42565088 243 HSTENKWEILKLFGEiqrqtKDRVARVRFNVSGKLLACQMAGKTIEIFRV 292
Cdd:COG2319 357 WDLATGELLRTLTGH-----TGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
10-436 3.06e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.91  E-value: 3.06e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088  10 AATSFGVISSVDSNIAYDSTGKYVLAPALEKVGIWHVRQGVCSKTLTPSSSrggpslAVTSIA-SSASSLVAVGYADGSI 88
Cdd:COG2319  71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG------AVRSVAfSPDGKTLASGSADGTV 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088  89 RIWDTEKGTCEVNFNSHKGAVTALRYNKVGSMLASGSKDNDIILWDVVGESGLFRLRGHRDQVTDLVFLDGGKKLVSSSK 168
Cdd:COG2319 145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 169 DKFLRVWDLETQHCMQIVSGHHSEVWSVDTDPEERYVVTGSADQELRFYavkeyssngslvsDSNANEIKASEEHSTenk 248
Cdd:COG2319 225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW-------------DLATGELLRTLTGHS--- 288

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 249 weilklfgeiqrqtkDRVARVRFNVSGKLLACQMAGKTIEIFRVldeaeakqkakrrlrrkekksskvgdenstANGeas 328
Cdd:COG2319 289 ---------------GGVNSVAFSPDGKLLASGSDDGTVRLWDL------------------------------ATG--- 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 329 akieladavssptvldvfKLLQVIRA-GRKISSFSFCPTApkeslGTLALSLNNNSLEFYSLKSSENAKTVTiehqGHRS 407
Cdd:COG2319 321 ------------------KLLRTLTGhTGAVRSVAFSPDG-----KTLASGSDDGTVRLWDLATGELLRTLT----GHTG 373

                       410       420       430
                ....*....|....*....|....*....|
gi 42565088 408 DVRSVTLSEDNTLLMSTSH-SEVKIWNPST 436
Cdd:COG2319 374 AVTSVAFSPDGRTLASGSAdGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 24-218 2.22e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.09  E-value: 2.22e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088  24 IAYDSTGKYVLA-PALEKVGIWHVRQGVCSKTLTpsssrgGPSLAVTSIA-SSASSLVAVGYADGSIRIWDTEKGTCEVN 101
Cdd:cd00200  99 VAFSPDGRILSSsSRDKTIKVWDVETGKCLTTLR------GHTDWVNSVAfSPDGTFVASSSQDGTIKLWDLRTGKCVAT 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 102 FNSHKGAVTALRYNKVGSMLASGSKDNDIILWDVVGESGLFRLRGHRDQVTDLVFLDGGKKLVSSSKDKFLRVWDLETQH 181
Cdd:cd00200 173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 42565088 182 CMQIVSGHHSEVWSVDTDPEERYVVTGSADQELRFYA 218
Cdd:cd00200 253 CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 24-217 1.26e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 1.26e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088  24 IAYDSTGKYVL-APALEKVGIWHVRQGVCSKTLTpsssrgGPSLAVTSIASSASS-LVAVGYADGSIRIWDTEKGTCEVN 101
Cdd:cd00200  15 VAFSPDGKLLAtGSGDGTIKVWDLETGELLRTLK------GHTGPVRDVAASADGtYLASGSSDKTIRLWDLETGECVRT 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 102 FNSHKGAVTALRYNKVGSMLASGSKDNDIILWDVVGESGLFRLRGHRDQVTDLVFLDGGKKLVSSSKDKFLRVWDLETQH 181
Cdd:cd00200  89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 42565088 182 CMQIVSGHHSEVWSVDTDPEERYVVTGSADQELRFY 217
Cdd:cd00200 169 CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-609 3.03e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.01  E-value: 3.03e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 102 FNSHKGAVTALRYNKVGSMLASGSKDNDIILWDVVGESGLFRLRGHRDQVTDLVFLDGGKKLVSSSKDKFLRVWDLETQH 181
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 182 CMQIVSGHHSEVWSVDTDPEERYVVTGSADQELRFyavkeyssngslvsdsnaneikaseehstenkWEILKlfgeiqrq 261
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKV--------------------------------WDVET-------- 124

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 262 tkdrvarvrfnvsgkllacqmagktieifrvldeaeakqkakrrlrrkekksskvgdenstangeasakieladavsspt 341
Cdd:cd00200     --------------------------------------------------------------------------------

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 342 vldvFKLLQVIRagrkissfsfcptapkeslgtlalslnnnslefyslkssenaktvtiehqGHRSDVRSVTLSEDNTLL 421
Cdd:cd00200 125 ----GKCLTTLR--------------------------------------------------GHTDWVNSVAFSPDGTFV 150

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 422 mSTSHSE--VKIWNPSTGSCLRTIdsgyglcslivpqnkygivgtksgvleiidigsatkveevKAHGGTIWSITPIPND 499
Cdd:cd00200 151 -ASSSQDgtIKLWDLRTGKCVATL----------------------------------------TGHTGEVNSVAFSPDG 189

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 500 SGFVTVSADHEVKFWEYQvkqkSGKATKKLTVSnvksmkmNDDVLAVAISPDAKHIAVALLDSTVKVFYMDSLKFYLSLY 579
Cdd:cd00200 190 EKLLSSSSDGTIKLWDLS----TGKCLGTLRGH-------ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258

                       490       500       510
                ....*....|....*....|....*....|
gi 42565088 580 GHKLPVMCIDISSDGELIVTGSQDKNLKIW 609
Cdd:cd00200 259 GHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 24-217 3.53e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.93  E-value: 3.53e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088  24 IAYDSTGKYVLAPALEK-VGIWHVRQGVCSKTLTPSSSrggpslAVTSIASSAS-SLVAVGYADGSIRIWDTEKGTCEVN 101
Cdd:cd00200  57 VAASADGTYLASGSSDKtIRLWDLETGECVRTLTGHTS------YVSSVAFSPDgRILSSSSRDKTIKVWDVETGKCLTT 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 102 FNSHKGAVTALRYNKVGSMLASGSKDNDIILWDVVGESGLFRLRGHRDQVTDLVFLDGGKKLVSSSKDKFLRVWDLETQH 181
Cdd:cd00200 131 LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK 210

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 42565088 182 CMQIVSGHHSEVWSVDTDPEERYVVTGSADQELRFY 217
Cdd:cd00200 211 CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-176 4.13e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 4.13e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088  22 SNIAYDSTGKYVLAPALEK-VGIWHVRQGVCSKTLTpsssrgGPSLAVTSIASSAS-SLVAVGYADGSIRIWDTEKGTCE 99
Cdd:cd00200 139 NSVAFSPDGTFVASSSQDGtIKLWDLRTGKCVATLT------GHTGEVNSVAFSPDgEKLLSSSSDGTIKLWDLSTGKCL 212

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42565088 100 VNFNSHKGAVTALRYNKVGSMLASGSKDNDIILWDVVGESGLFRLRGHRDQVTDLVFLDGGKKLVSSSKDKFLRVWD 176
Cdd:cd00200 213 GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
541-694 1.12e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 1.12e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 541 DDVLAVAISPDAKHIAVALLDSTVKVFYMDSLKFYLSLYGHKLPVMCIDISSDGELIVTGSQDKNLKIWGLDFGDCHKSI 620
Cdd:COG2319  37 AAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL 116

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42565088 621 FAHGDSVMGVKFVRNTHYLFSIGKDRLVKYWDADKFEHLLTLEGHHAEIWCLAISNRGDFLVTGSHDRSMRRWD 694
Cdd:COG2319 117 TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 795-898 2.86e-22

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 92.23  E-value: 2.86e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088   795 PSEYVLRA-ISNVRTNDLEQTLLALPFSDSLKFLCYMKDWSL-IPEKVELVSRIATIILQTHHNQLVTTPSARPILSVLR 872
Cdd:pfam04003   1 NDEYLLESvLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAeRSPHLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*.
gi 42565088   873 DILYSEIKACKDTIGFNLAAMDHVKQ 898
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 COG2319
WD40 repeat [General function prediction only];
547-694 5.26e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 5.26e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 547 AISPDAKHIAVALLDSTVKVFYMDSLKFYLSLYGHKLPVMCIDISSDGELIVTGSQDKNLKIWGLDFGDCHKSIFAHGDS 626
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42565088 627 VMGVKFVRNTHYLFSIGKDRLVKYWDADKFEHLLTLEGHHAEIWCLAISNRGDFLVTGSHDRSMRRWD 694
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 616-694 2.20e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 2.20e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42565088 616 CHKSIFAHGDSVMGVKFVRNTHYLFSIGKDRLVKYWDADKFEHLLTLEGHHAEIWCLAISNRGDFLVTGSHDRSMRRWD 694
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 71-217 2.14e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 2.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088   71 IASSASSLVAVGYADGSIRIWDTEKGTcEVNFNSHKGAVTALRY-NKVGSMLASGSKDNDIILWDVVGES-GLFRLRGHR 148
Cdd:PLN00181 583 YSSADPTLLASGSDDGSVKLWSINQGV-SIGTIKTKANICCVQFpSESGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHS 661

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42565088  149 DQVTDLVFLDGgKKLVSSSKDKFLRVWDLE------TQHCMQIVSGHHSEVWSVDTDPEERYVVTGSADQELRFY 217
Cdd:PLN00181 662 KTVSYVRFVDS-STLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVY 735
WD40 pfam00400
WD domain, G-beta repeat;
656-694 7.99e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 7.99e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 42565088   656 FEHLLTLEGHHAEIWCLAISNRGDFLVTGSHDRSMRRWD 694
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
573-609 8.73e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 8.73e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 42565088   573 KFYLSLYGHKLPVMCIDISSDGELIVTGSQDKNLKIW 609
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 655-694 1.03e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 1.03e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 42565088    655 KFEHLLTLEGHHAEIWCLAISNRGDFLVTGSHDRSMRRWD 694
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 571-609 1.36e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.36e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 42565088    571 SLKFYLSLYGHKLPVMCIDISSDGELIVTGSQDKNLKIW 609
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 95-134 2.68e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 2.68e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 42565088     95 KGTCEVNFNSHKGAVTALRYNKVGSMLASGSKDNDIILWD 134
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 141-176 1.15e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.15e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 42565088    141 LFRLRGHRDQVTDLVFLDGGKKLVSSSKDKFLRVWD 176
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
96-134 1.30e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.30e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 42565088    96 GTCEVNFNSHKGAVTALRYNKVGSMLASGSKDNDIILWD 134
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
141-176 2.29e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 2.29e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 42565088   141 LFRLRGHRDQVTDLVFLDGGKKLVSSSKDKFLRVWD 176
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
591-696 4.17e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.21  E-value: 4.17e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088 591 SSDGELIVTGSQDKNLKIWGLDFGDCHKSIFAHGDSVMGVKFVRNTHYLFSIGKDRLVKYWDADKFEHLLTLEGHHAEIW 670
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100
                ....*....|....*....|....*.
gi 42565088 671 CLAISNRGDFLVTGSHDRSMRRWDRS 696
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLWDLA 108
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 554-696 1.88e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 1.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088  554 HIAVALLDSTVKVFYMDSLKFYLSLYGHKLPVMCIDISS-DGELIVTGSQDKNLKIWGLDFGDCHKSIFAHGDsVMGVKF 632
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQF 625

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42565088  633 VRNTHYLFSIGK-DRLVKYWDADKFE-HLLTLEGHHAEIWCLAISNRGDfLVTGSHDRSMRRWDRS 696
Cdd:PLN00181 626 PSESGRSLAFGSaDHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLS 690
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 581-687 1.89e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 44.68  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088   581 HKLPVMCIDISSDGELIVTGSQDKNLKIWgldfgdchkSIFAHGDSvmgVKFVRNTHYLFSiGKDRLVkywdADKFEHLL 660
Cdd:pfam20426 123 HKDVVSCVAVTSDGSILATGSYDTTVMVW---------EVLRGRSS---EKRSRNTQTEFP-RKDHVI----AETPFHIL 185

                          90       100
                  ....*....|....*....|....*..
gi 42565088   661 TleGHHAEIWCLAISNRGDFLVTGSHD 687
Cdd:pfam20426 186 C--GHDDIITCLYVSVELDIVISGSKD 210
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-217 4.85e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 4.85e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 42565088    179 TQHCMQIVSGHHSEVWSVDTDPEERYVVTGSADQELRFY 217
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 60-112 8.37e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 8.37e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 42565088    60 SRGGPSLAVTSIASSAS-SLVAVGYADGSIRIWDTEKGTCEVNFNSHKGAVTAL 112
Cdd:pfam12894  33 SPDKEDLEVTSLAWRPDgKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCL 86
WD40 pfam00400
WD domain, G-beta repeat;
182-217 8.62e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 8.62e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 42565088   182 CMQIVSGHHSEVWSVDTDPEERYVVTGSADQELRFY 217
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 68-127 1.78e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.80  E-value: 1.78e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088   68 VTSIASSASSLVAVGYADGSIRIWDTEKGTCEVNFNSHKGAVTALRYNKVGSMLASGSKD 127
Cdd:PTZ00421 130 IVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKD 189
WD40_like pfam17005
WD40-like domain; This is a family of proteins which have weak homology to the WD40 repeat ...
 584-639 2.00e-03

WD40-like domain; This is a family of proteins which have weak homology to the WD40 repeat family. Members are largely from microsporidia and related species.


Pssm-ID: 407205 [Multi-domain]  Cd Length: 301  Bit Score: 41.19  E-value: 2.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 42565088   584 PVMCIDISSDGELIVTGSQDKNLKIWGLDFGDCHKSIFAHGDSVMGVKFVRNTHYL 639
Cdd:pfam17005   2 EIYSIDISKKGSYILYGGKDDTCTVYDFENLDLVSIVEGFSDSVIFCKFLDDDLIL 57
PTZ00421 PTZ00421
coronin; Provisional
 119-236 5.76e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 40.26  E-value: 5.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42565088  119 SMLASGSKDNDIILWDVVGE-------SGLFRLRGHRDQVTDLVFLDGGKK-LVSSSKDKFLRVWDLETQHCMQIVSGHH 190
Cdd:PTZ00421  89 QKLFTASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVNVWDVERGKAVEVIKCHS 168

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 42565088  191 SEVWSVDTDPEERYVVTGSADQELRFYAVKeyssNGSLVSDSNANE 236
Cdd:PTZ00421 169 DQITSLEWNLDGSLLCTTSKDKKLNIIDPR----DGTIVSSVEAHA 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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