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Conserved domains on  [gi|42564137|ref|NP_188011|]
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ankyrin [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PGG super family cl16503
Domain of unknown function; The PGG domain is named for the highly conserved sequence motif ...
 28-154 2.35e-17

Domain of unknown function; The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.


The actual alignment was detected with superfamily member pfam13962:

Pssm-ID: 433609  Cd Length: 114  Bit Score: 74.13  E-value: 2.35e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42564137    28 DWLEKTRGNLMVTATVIAGMSFQVMVNPPGGVWQSDNcsfgnqtgtapfcKGRAGTAVLeyesSKRIAYIGMIISSTVSF 107
Cdd:pfam13962   2 EWLKEARNTLLLVATLIATVTFAAGFTPPGGYWQDDD-------------GPHAGKPIL----AKNPAFKAFVISNAIAF 64

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 42564137   108 STSMSLILLVISGIRLRNR---MIMAILGTFMVVAVLCISAAFFFAIVLV 154
Cdd:pfam13962  65 FASLVAVVLLLSIVSDFLRslpRKLRIGLKLLWVALLSMLVAFAAGSYRV 114
 
Name Accession Description Interval E-value
PGG pfam13962
Domain of unknown function; The PGG domain is named for the highly conserved sequence motif ...
 28-154 2.35e-17

Domain of unknown function; The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.


Pssm-ID: 433609  Cd Length: 114  Bit Score: 74.13  E-value: 2.35e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42564137    28 DWLEKTRGNLMVTATVIAGMSFQVMVNPPGGVWQSDNcsfgnqtgtapfcKGRAGTAVLeyesSKRIAYIGMIISSTVSF 107
Cdd:pfam13962   2 EWLKEARNTLLLVATLIATVTFAAGFTPPGGYWQDDD-------------GPHAGKPIL----AKNPAFKAFVISNAIAF 64

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 42564137   108 STSMSLILLVISGIRLRNR---MIMAILGTFMVVAVLCISAAFFFAIVLV 154
Cdd:pfam13962  65 FASLVAVVLLLSIVSDFLRslpRKLRIGLKLLWVALLSMLVAFAAGSYRV 114
TMEM168 cd21494
Transmembrane (TMEM) protein family 168; This family includes transmembrane protein 168 ...
 97-149 9.48e-03

Transmembrane (TMEM) protein family 168; This family includes transmembrane protein 168 (TMEM168) and similar proteins. TMEM168 is a multi-pass membrane protein predicted to contain nine transmembrane helices. Its expression has been implicated in several diseases. It is upregulated in glioblastoma multiforme (GBM) and small interfering RNA (siRNA)-TMEM168 has been shown to prevent viability of human GBM cell lines, induce cell cycle arrest (G0/G1 phase), and promote apoptosis through the suppression of the Wnt/beta-catenin pathway. A TMEM168 point mutation has also been associated with arrhythmogenesis in familial Brugada syndrome.


Pssm-ID: 411069  Cd Length: 681  Bit Score: 36.53  E-value: 9.48e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 42564137  97 IGMIISSTVSFSTSMSLILLV------ISGIRLRNRMIMAILGTFmvvavLCISAAFFF 149
Cdd:cd21494 147 VGFAIATTMLVQKSLSVILLVlalamlIIDLRLKSFLAIPNLIVF-----AVISALLFF 200
 
Name Accession Description Interval E-value
PGG pfam13962
Domain of unknown function; The PGG domain is named for the highly conserved sequence motif ...
 28-154 2.35e-17

Domain of unknown function; The PGG domain is named for the highly conserved sequence motif found at the startt of the domain. The function is not known.


Pssm-ID: 433609  Cd Length: 114  Bit Score: 74.13  E-value: 2.35e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42564137    28 DWLEKTRGNLMVTATVIAGMSFQVMVNPPGGVWQSDNcsfgnqtgtapfcKGRAGTAVLeyesSKRIAYIGMIISSTVSF 107
Cdd:pfam13962   2 EWLKEARNTLLLVATLIATVTFAAGFTPPGGYWQDDD-------------GPHAGKPIL----AKNPAFKAFVISNAIAF 64

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 42564137   108 STSMSLILLVISGIRLRNR---MIMAILGTFMVVAVLCISAAFFFAIVLV 154
Cdd:pfam13962  65 FASLVAVVLLLSIVSDFLRslpRKLRIGLKLLWVALLSMLVAFAAGSYRV 114
TMEM168 cd21494
Transmembrane (TMEM) protein family 168; This family includes transmembrane protein 168 ...
 97-149 9.48e-03

Transmembrane (TMEM) protein family 168; This family includes transmembrane protein 168 (TMEM168) and similar proteins. TMEM168 is a multi-pass membrane protein predicted to contain nine transmembrane helices. Its expression has been implicated in several diseases. It is upregulated in glioblastoma multiforme (GBM) and small interfering RNA (siRNA)-TMEM168 has been shown to prevent viability of human GBM cell lines, induce cell cycle arrest (G0/G1 phase), and promote apoptosis through the suppression of the Wnt/beta-catenin pathway. A TMEM168 point mutation has also been associated with arrhythmogenesis in familial Brugada syndrome.


Pssm-ID: 411069  Cd Length: 681  Bit Score: 36.53  E-value: 9.48e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 42564137  97 IGMIISSTVSFSTSMSLILLV------ISGIRLRNRMIMAILGTFmvvavLCISAAFFF 149
Cdd:cd21494 147 VGFAIATTMLVQKSLSVILLVlalamlIIDLRLKSFLAIPNLIVF-----AVISALLFF 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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