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Conserved domains on  [gi|30680129|ref|NP_187366|]
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Sec23/Sec24 protein transport family protein [Arabidopsis thaliana]

Protein Classification

SEC24 family transport protein( domain architecture ID 1001573)

SEC24 family transport protein is a component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5028 super family cl34873
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 167-1036 0e+00

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5028:

Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 551.71  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  167 PGANAYPPATDYHMPARPGFQQSMPPVTPSYPGVGG--SQPSFPGYPSKQVLQAPTPFQTSQGPPGPPPVSSYPPHTGGF 244
Cdd:COG5028    4 HKKGVYPQAQSQVHTGAASSKKSARPHRAYANFSAGqmGMPPYTTPPLQQQSRRQIDQAATAMHNTGANNPAPSVMSPAF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  245 AQRPNMAAQ--QNLHPNYAPPPSNVQGLTEDFNSLSLssipgslePGLDHKSFPRPLDGDVEPNSFAEMYpMNCHSRYLR 322
Cdd:COG5028   84 QSQQKFSSPygGSMADGTAPKPTNPLVPVDLFEDQPP--------PISDLFLPPPPIVPPLTTNFVGSEQ-SNCSPKYVR 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  323 LTTSAIPNSQSLASRWHLPLGAVVCPLAE-TPEGEEVPLIDFGStgIIRCRRCRTYVNPFVTFTDSGRKWRCNICSMLND 401
Cdd:COG5028  155 STMYAIPETNDLLKKSKIPFGLVIRPFLElYPEEDPVPLVEDGS--IVRCRRCRSYINPFVQFIEQGRKWRCNICRSKND 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  402 VPGEYFSHLDATGRRMDMDQRPELTKGSVEIIAPTEYMVRPPMPPIYFFLIDVSISATKSGMLEVVAQTIKSCLDNLPGY 481
Cdd:COG5028  233 VPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILENLDQIPNF 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  482 -PRTQIGFITYDSTLHFYNmKSSLSQPQMMVVSDLDDIFVPLP-DDLLVNLSESRTVVDAFLDSLPLMFQDNFNVESAFG 559
Cdd:COG5028  313 dPRTKIAIICFDSSLHFFK-LSPDLDEQMLIVSDLDEPFLPFPsGLFVLPLKSCKQIIETLLDRVPRIFQDNKSPKNALG 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  560 PALRAAFMVMNQLGGKLLIFQNSLPSLGAGRLKLRgddprvygTDKEYALRVAEDPFYKQMAADCTKFQIGINVYAFSDK 639
Cdd:COG5028  392 PALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLR--------EDKESSLLSCKDSFYKEFAIECSKVGISVDLFLTSED 463

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  640 YTDIASLGTLAKYTGGQVYYYPGFQSSVHGD--KLRHELARDLTRETAWEAVMRIRCGKGIRFSSYHGNFMLRSTDLLAL 717
Cdd:COG5028  464 YIDVATLSHLCRYTGGQTYFYPNFSATRPNDatKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNRSSDLCAF 543

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  718 PAVDCDKAYAMQLSLEETLLTSQtVYFQVALLYTASCGERRIRVHTSVAPVVTDLGEMYRQADTGSIVSLYARLAIEKSL 797
Cdd:COG5028  544 STMPRDTSLLVEFSIDEKLMTSD-VYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAKKASTKAL 622

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  798 SAKLDDARNAIQQKIVKALKEYRNLHAVQHrLGSRLVYPESLKFLPLYGLAITKSTPLLGGpaDTSLDERCAAGFTMMAL 877
Cdd:COG5028  623 NSSLKEARVLINKSMVDILKAYKKELVKSN-TSTQLPLPANLKLLPLLMLALLKSSAFRSG--STPSDIRISALNRLTSL 699

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  878 PVKKLLKLLYPNLFRVDEwlLKPSAAHDDFKDVLRRLPLAA--ESLDSRGLYIYDDGFRLVLWFGRMLSPDIAKNLLGVD 955
Cdd:COG5028  700 PLKQLMRNIYPTLYALHD--MPIEAGLPDEGLLVLPSPINAtsSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDLFGVD 777

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  956 FAADLS--RVTFQEQENGMSKKLMRLVKKLRESDPSYHPMCFLVRQGEQPREGFLLLRNLIEDQMGGSSGYVDWILQLHR 1033
Cdd:COG5028  778 SLSDIPsgKFTLPPTGNEFNERVRNIIGELRSVNDDSTLPLVLVRGGGDPSLRLWFFSTLVEDKTLNIPSYLDYLQILHE 857


                 ...
gi 30680129 1034 QVQ 1036
Cdd:COG5028  858 KIK 860
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 2-324 3.16e-12

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 71.51  E-value: 3.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     2 GTENQGYPNFPARPA--SSPFASAPP---PGIPPQSGGPPTGSEAVGFRPFTPSASQPTRPFTASGPPPAPPVGTMRPGQ 76
Cdd:PHA03247 2747 GPATPGGPARPARPPttAGPPAPAPPaapAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG 2826

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    77 PSPFVSQIPGSRPPPPSSNSFPSPAYG---PPGGAPFQRFPSPPFPTTQNPPQGPPPPQTLAGHLSPPMSLRPQQPMAPv 153
Cdd:PHA03247 2827 PLPPPTSAQPTAPPPPPGPPPPSLPLGgsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP- 2905

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   154 AMGPPPQSTTSGLPGANAYPPATDYHMPARPGFQQSMPPVTPSYPGVGGSQPSFPGYPSKQVLQAPTP---FQTSQGPPG 230
Cdd:PHA03247 2906 ERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvprFRVPQPAPS 2985

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   231 --PPPVSSYPPHTGGFAQRPNMAAQQNLHPNYAPPP-------------------SNVQGLTEDFNSLSLSSIPGSLEPG 289
Cdd:PHA03247 2986 reAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPvslkqtlwppddtedsdadSLFDSDSERSDLEALDPLPPEPHDP 3065

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 30680129   290 LDHKSFPRPLDGDVE--PNSFAEMYPMNCHS----RYLRLT 324
Cdd:PHA03247 3066 FAHEPDPATPEAGAResPSSQFGPPPLSANAalsrRYVRST 3106
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 167-1036 0e+00

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 551.71  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  167 PGANAYPPATDYHMPARPGFQQSMPPVTPSYPGVGG--SQPSFPGYPSKQVLQAPTPFQTSQGPPGPPPVSSYPPHTGGF 244
Cdd:COG5028    4 HKKGVYPQAQSQVHTGAASSKKSARPHRAYANFSAGqmGMPPYTTPPLQQQSRRQIDQAATAMHNTGANNPAPSVMSPAF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  245 AQRPNMAAQ--QNLHPNYAPPPSNVQGLTEDFNSLSLssipgslePGLDHKSFPRPLDGDVEPNSFAEMYpMNCHSRYLR 322
Cdd:COG5028   84 QSQQKFSSPygGSMADGTAPKPTNPLVPVDLFEDQPP--------PISDLFLPPPPIVPPLTTNFVGSEQ-SNCSPKYVR 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  323 LTTSAIPNSQSLASRWHLPLGAVVCPLAE-TPEGEEVPLIDFGStgIIRCRRCRTYVNPFVTFTDSGRKWRCNICSMLND 401
Cdd:COG5028  155 STMYAIPETNDLLKKSKIPFGLVIRPFLElYPEEDPVPLVEDGS--IVRCRRCRSYINPFVQFIEQGRKWRCNICRSKND 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  402 VPGEYFSHLDATGRRMDMDQRPELTKGSVEIIAPTEYMVRPPMPPIYFFLIDVSISATKSGMLEVVAQTIKSCLDNLPGY 481
Cdd:COG5028  233 VPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILENLDQIPNF 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  482 -PRTQIGFITYDSTLHFYNmKSSLSQPQMMVVSDLDDIFVPLP-DDLLVNLSESRTVVDAFLDSLPLMFQDNFNVESAFG 559
Cdd:COG5028  313 dPRTKIAIICFDSSLHFFK-LSPDLDEQMLIVSDLDEPFLPFPsGLFVLPLKSCKQIIETLLDRVPRIFQDNKSPKNALG 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  560 PALRAAFMVMNQLGGKLLIFQNSLPSLGAGRLKLRgddprvygTDKEYALRVAEDPFYKQMAADCTKFQIGINVYAFSDK 639
Cdd:COG5028  392 PALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLR--------EDKESSLLSCKDSFYKEFAIECSKVGISVDLFLTSED 463

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  640 YTDIASLGTLAKYTGGQVYYYPGFQSSVHGD--KLRHELARDLTRETAWEAVMRIRCGKGIRFSSYHGNFMLRSTDLLAL 717
Cdd:COG5028  464 YIDVATLSHLCRYTGGQTYFYPNFSATRPNDatKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNRSSDLCAF 543

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  718 PAVDCDKAYAMQLSLEETLLTSQtVYFQVALLYTASCGERRIRVHTSVAPVVTDLGEMYRQADTGSIVSLYARLAIEKSL 797
Cdd:COG5028  544 STMPRDTSLLVEFSIDEKLMTSD-VYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAKKASTKAL 622

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  798 SAKLDDARNAIQQKIVKALKEYRNLHAVQHrLGSRLVYPESLKFLPLYGLAITKSTPLLGGpaDTSLDERCAAGFTMMAL 877
Cdd:COG5028  623 NSSLKEARVLINKSMVDILKAYKKELVKSN-TSTQLPLPANLKLLPLLMLALLKSSAFRSG--STPSDIRISALNRLTSL 699

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  878 PVKKLLKLLYPNLFRVDEwlLKPSAAHDDFKDVLRRLPLAA--ESLDSRGLYIYDDGFRLVLWFGRMLSPDIAKNLLGVD 955
Cdd:COG5028  700 PLKQLMRNIYPTLYALHD--MPIEAGLPDEGLLVLPSPINAtsSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDLFGVD 777

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  956 FAADLS--RVTFQEQENGMSKKLMRLVKKLRESDPSYHPMCFLVRQGEQPREGFLLLRNLIEDQMGGSSGYVDWILQLHR 1033
Cdd:COG5028  778 SLSDIPsgKFTLPPTGNEFNERVRNIIGELRSVNDDSTLPLVLVRGGGDPSLRLWFFSTLVEDKTLNIPSYLDYLQILHE 857


                 ...
gi 30680129 1034 QVQ 1036
Cdd:COG5028  858 KIK 860
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
 443-684 8.15e-127

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 385.47  E-value: 8.15e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  443 PMPPIYFFLIDVSISATKSGMLEVVAQTIKSCLDNLPGY-PRTQIGFITYDSTLHFYNMKSSLSQPQMMVVSDLDDIFVP 521
Cdd:cd01479    1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  522 LPDDLLVNLSESRTVVDAFLDSLPLMFQDNFNVESAFGPALRAAFMVMNQLGGKLLIFQNSLPSLGAGRLKLRgDDPRVY 601
Cdd:cd01479   81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSR-EDPKLL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  602 GTDKEYALRVAEDPFYKQMAADCTKFQIGINVYAFSDKYTDIASLGTLAKYTGGQVYYYPG--FQSSVHGDKLRHELARD 679
Cdd:cd01479  160 STDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSfnFSAPNDVEKLVNELARY 239


                 ....*
gi 30680129  680 LTRET 684
Cdd:cd01479  240 LTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 443-680 9.89e-109

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 337.69  E-value: 9.89e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    443 PMPPIYFFLIDVSISATKSGMLEVVAQTIKSCLDNLPGYPRTQIGFITYDSTLHFYNMKSSLSQPQMMVVSDLDDIFVPL 522
Cdd:pfam04811    1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    523 PDDLLVNLSESRTVVDAFLDSLPLMFQDNFNVESAFGPALRAAFMVMN--QLGGKLLIFQNSLPSLGA-GRLKLRgDDPR 599
Cdd:pfam04811   81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLKaaFTGGKIMVFQGGLPTVGPgGKLKSR-LDES 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    600 VYGTDKEYA-LRVAEDPFYKQMAADCTKFQIGINVYAFSDKYTDIASLGTLAKYTGGQVYYYPGFQSSVHGDKLRHELAR 678
Cdd:pfam04811  160 HHGTDKEKAkLVKKADKFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADVDGSKFKQDLQR 239


                   ..
gi 30680129    679 DL 680
Cdd:pfam04811  240 YF 241
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 440-1037 2.52e-37

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 152.92  E-value: 2.52e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   440 VRPPMPPIYFFLIDVSISATKSGMLEVVAQTIKSCLDNLPgYPRTQIGFITYDSTLHFYNMKSSLSQP------------ 507
Cdd:PTZ00395  947 VKNMLPPYFVFVVECSYNAIYNNITYTILEGIRYAVQNVK-CPQTKIAIITFNSSIYFYHCKGGKGVSgeegdggggsgn 1025

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   508 -QMMVVSDLDDIFVPLP-DDLLVNLSESRTVVDAFLDSLPLMFQDNFNVESAFGPALRAAFMVMNQLGG--KLLIFQNSL 583
Cdd:PTZ00395 1026 hQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIKSVSTTMQSYGSCGNSALKIAMDMLKERNGlgSICMFYTTT 1105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   584 PSLGAGRLKLRGDDPrvygtdKEYALRVAEDPFYKQMAADCTKFQIGINVYAFSDKYTDIA--SLGTLAKYTGGQVYYYP 661
Cdd:PTZ00395 1106 PNCGIGAIKELKKDL------QENFLEVKQKIFYDSLLLDLYAFNISVDIFIISSNNVRVCvpSLQYVAQNTGGKILFVE 1179

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   662 GFQSSVHGDKLRHELARDLTRETaweavMRIRCGKGIRFSSY---------HGNF-MLRSTDLLALPAVDCDKAYAMQLS 731
Cdd:PTZ00395 1180 NFLWQKDYKEIYMNIMDTLTSED-----IAYCCELKLRYSHHmsvkklfccNNNFnSIISVDTIKIPKIRHDQTFAFLLN 1254

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   732 LEETLLTSQTVYFQVALLYTASCGERRIRVHTSVAPVVTDLGEMYRQADTGSIVSLYARLAIEKSLSAklDDARNAIQQK 811
Cdd:PTZ00395 1255 YSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTDAEALMNILIKQLCTNILHN--DNYSKIIIDN 1332

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   812 IVKALKEYR-NLHAVQHrlGSRLVYPESLKFLPLYGLAITKSTPLlggPADTSLDERCAAGFTMMALPVKKLLKLLYPNL 890
Cdd:PTZ00395 1333 LAAILFSYRiNCASSAH--SGQLILPDTLKLLPLFTSSLLKHNVT---KKEILHDLKVYSLIKLLSMPIISSLLYVYPVM 1407

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   891 FRVDewlLKPSAAHDDFKDV------LRRLPLAAESLDSRGLYIYDDGFRLVLWFGRMLSPDIAKNLLGvDFAADLSRVT 964
Cdd:PTZ00395 1408 YVIH---IKGKTNEIDSMDVdddlfiPKTIPSSAEKIYSNGIYLLDACTHFYLYFGFHSDANFAKEIVG-DIPTEKNAHE 1483

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30680129   965 FQEQENGMSKKLMRLVKKLRESD--PSYHPMCFLV-RQGEQPRegflLLRNLIEDQMGGSSGYVDWILQLHRQVQQ 1037
Cdd:PTZ00395 1484 LNLTDTPNAQKVQRIIKNLSRIHhfNKYVPLVMVApKSNEEEH----LISLCVEDKADKEYSYVNFLCFIHKLVHK 1555
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2-324 3.16e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 71.51  E-value: 3.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     2 GTENQGYPNFPARPA--SSPFASAPP---PGIPPQSGGPPTGSEAVGFRPFTPSASQPTRPFTASGPPPAPPVGTMRPGQ 76
Cdd:PHA03247 2747 GPATPGGPARPARPPttAGPPAPAPPaapAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG 2826

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    77 PSPFVSQIPGSRPPPPSSNSFPSPAYG---PPGGAPFQRFPSPPFPTTQNPPQGPPPPQTLAGHLSPPMSLRPQQPMAPv 153
Cdd:PHA03247 2827 PLPPPTSAQPTAPPPPPGPPPPSLPLGgsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP- 2905

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   154 AMGPPPQSTTSGLPGANAYPPATDYHMPARPGFQQSMPPVTPSYPGVGGSQPSFPGYPSKQVLQAPTP---FQTSQGPPG 230
Cdd:PHA03247 2906 ERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvprFRVPQPAPS 2985

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   231 --PPPVSSYPPHTGGFAQRPNMAAQQNLHPNYAPPP-------------------SNVQGLTEDFNSLSLSSIPGSLEPG 289
Cdd:PHA03247 2986 reAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPvslkqtlwppddtedsdadSLFDSDSERSDLEALDPLPPEPHDP 3065

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 30680129   290 LDHKSFPRPLDGDVE--PNSFAEMYPMNCHS----RYLRLT 324
Cdd:PHA03247 3066 FAHEPDPATPEAGAResPSSQFGPPPLSANAalsrRYVRST 3106
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 15-194 2.44e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.95  E-value: 2.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     15 PASSPFASAPPPGIPPQSGGPPTGSEAV--------GFRPFTPSASQPTRPFTASGPPPAPPVGTMRPGQPSPFVSQIPG 86
Cdd:pfam09770  166 APKKAAAPAPAPQPAAQPASLPAPSRKMmsleeveaAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQ 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     87 SRPPPPSSNsfpspaYGPPGGAPFQRFPSPPFPTTQNPPQGPPPPQTLAGHLSPPMSLRPQQPMAPVAMGPPPQSTTSGL 166
Cdd:pfam09770  246 PQQQPQQPQ------QHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQN 319

                          170       180
                   ....*....|....*....|....*...
gi 30680129    167 PGANAYPPATDYHMPARPGFQQSMPPVT 194
Cdd:pfam09770  320 PQPGVQPAPAHQAHRQQGSFGRQAPIIT 347
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 13-221 3.10e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 41.59  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   13 ARPASSPFASAPPPGIPPQSGGPPTGSEAVGFRPFTPSASQPTRPF--TASGPPPAPPV--GTMRPGQPSPFVSQIPGSR 88
Cdd:COG5180  224 PRPEAASSPKVDPPSTSEARSRPATVDAQPEMRPPADAKERRRAAIgdTPAAEPPGLPVleAGSEPQSDAPEAETARPID 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   89 PPPPssnsfpspAYGPPGGAPFQRFPSPPFPTTQNPPQGPPPPQTLAGHLS----PPMSLRPQQPMAPVAMGPP--PQST 162
Cdd:COG5180  304 VKGV--------ASAPPATRPVRPPGGARDPGTPRPGQPTERPAGVPEAASdagqPPSAYPPAEEAVPGKPLEQgaPRPG 375

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30680129  163 TSGLPGANAYPP-ATDYHMPARPGFQ-QSMPPVTPSYPGVGGSQPSF--PGYPSKQVLQAPTP 221
Cdd:COG5180  376 SSGGDGAPFQPPnGAPQPGLGRRGAPgPPMGAGDLVQAALDGGGRETasLGGAAGGAGQGPKA 438
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
 167-1036 0e+00

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 551.71  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  167 PGANAYPPATDYHMPARPGFQQSMPPVTPSYPGVGG--SQPSFPGYPSKQVLQAPTPFQTSQGPPGPPPVSSYPPHTGGF 244
Cdd:COG5028    4 HKKGVYPQAQSQVHTGAASSKKSARPHRAYANFSAGqmGMPPYTTPPLQQQSRRQIDQAATAMHNTGANNPAPSVMSPAF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  245 AQRPNMAAQ--QNLHPNYAPPPSNVQGLTEDFNSLSLssipgslePGLDHKSFPRPLDGDVEPNSFAEMYpMNCHSRYLR 322
Cdd:COG5028   84 QSQQKFSSPygGSMADGTAPKPTNPLVPVDLFEDQPP--------PISDLFLPPPPIVPPLTTNFVGSEQ-SNCSPKYVR 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  323 LTTSAIPNSQSLASRWHLPLGAVVCPLAE-TPEGEEVPLIDFGStgIIRCRRCRTYVNPFVTFTDSGRKWRCNICSMLND 401
Cdd:COG5028  155 STMYAIPETNDLLKKSKIPFGLVIRPFLElYPEEDPVPLVEDGS--IVRCRRCRSYINPFVQFIEQGRKWRCNICRSKND 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  402 VPGEYFSHLDATGRRMDMDQRPELTKGSVEIIAPTEYMVRPPMPPIYFFLIDVSISATKSGMLEVVAQTIKSCLDNLPGY 481
Cdd:COG5028  233 VPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLAPKEYSLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILENLDQIPNF 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  482 -PRTQIGFITYDSTLHFYNmKSSLSQPQMMVVSDLDDIFVPLP-DDLLVNLSESRTVVDAFLDSLPLMFQDNFNVESAFG 559
Cdd:COG5028  313 dPRTKIAIICFDSSLHFFK-LSPDLDEQMLIVSDLDEPFLPFPsGLFVLPLKSCKQIIETLLDRVPRIFQDNKSPKNALG 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  560 PALRAAFMVMNQLGGKLLIFQNSLPSLGAGRLKLRgddprvygTDKEYALRVAEDPFYKQMAADCTKFQIGINVYAFSDK 639
Cdd:COG5028  392 PALKAAKSLIGGTGGKIIVFLSTLPNMGIGKLQLR--------EDKESSLLSCKDSFYKEFAIECSKVGISVDLFLTSED 463

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  640 YTDIASLGTLAKYTGGQVYYYPGFQSSVHGD--KLRHELARDLTRETAWEAVMRIRCGKGIRFSSYHGNFMLRSTDLLAL 717
Cdd:COG5028  464 YIDVATLSHLCRYTGGQTYFYPNFSATRPNDatKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNRSSDLCAF 543

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  718 PAVDCDKAYAMQLSLEETLLTSQtVYFQVALLYTASCGERRIRVHTSVAPVVTDLGEMYRQADTGSIVSLYARLAIEKSL 797
Cdd:COG5028  544 STMPRDTSLLVEFSIDEKLMTSD-VYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAKKASTKAL 622

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  798 SAKLDDARNAIQQKIVKALKEYRNLHAVQHrLGSRLVYPESLKFLPLYGLAITKSTPLLGGpaDTSLDERCAAGFTMMAL 877
Cdd:COG5028  623 NSSLKEARVLINKSMVDILKAYKKELVKSN-TSTQLPLPANLKLLPLLMLALLKSSAFRSG--STPSDIRISALNRLTSL 699

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  878 PVKKLLKLLYPNLFRVDEwlLKPSAAHDDFKDVLRRLPLAA--ESLDSRGLYIYDDGFRLVLWFGRMLSPDIAKNLLGVD 955
Cdd:COG5028  700 PLKQLMRNIYPTLYALHD--MPIEAGLPDEGLLVLPSPINAtsSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDLFGVD 777

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  956 FAADLS--RVTFQEQENGMSKKLMRLVKKLRESDPSYHPMCFLVRQGEQPREGFLLLRNLIEDQMGGSSGYVDWILQLHR 1033
Cdd:COG5028  778 SLSDIPsgKFTLPPTGNEFNERVRNIIGELRSVNDDSTLPLVLVRGGGDPSLRLWFFSTLVEDKTLNIPSYLDYLQILHE 857


                 ...
gi 30680129 1034 QVQ 1036
Cdd:COG5028  858 KIK 860
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
 443-684 8.15e-127

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 385.47  E-value: 8.15e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  443 PMPPIYFFLIDVSISATKSGMLEVVAQTIKSCLDNLPGY-PRTQIGFITYDSTLHFYNMKSSLSQPQMMVVSDLDDIFVP 521
Cdd:cd01479    1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDdPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDDPFLP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  522 LPDDLLVNLSESRTVVDAFLDSLPLMFQDNFNVESAFGPALRAAFMVMNQLGGKLLIFQNSLPSLGAGRLKLRgDDPRVY 601
Cdd:cd01479   81 LPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLKETGGKIIVFQSSLPTLGAGKLKSR-EDPKLL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  602 GTDKEYALRVAEDPFYKQMAADCTKFQIGINVYAFSDKYTDIASLGTLAKYTGGQVYYYPG--FQSSVHGDKLRHELARD 679
Cdd:cd01479  160 STDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSfnFSAPNDVEKLVNELARY 239


                 ....*
gi 30680129  680 LTRET 684
Cdd:cd01479  240 LTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 443-680 9.89e-109

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 337.69  E-value: 9.89e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    443 PMPPIYFFLIDVSISATKSGMLEVVAQTIKSCLDNLPGYPRTQIGFITYDSTLHFYNMKSSLSQPQMMVVSDLDDIFVPL 522
Cdd:pfam04811    1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQDMFLPL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    523 PDDLLVNLSESRTVVDAFLDSLPLMFQDNFNVESAFGPALRAAFMVMN--QLGGKLLIFQNSLPSLGA-GRLKLRgDDPR 599
Cdd:pfam04811   81 PDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLKaaFTGGKIMVFQGGLPTVGPgGKLKSR-LDES 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    600 VYGTDKEYA-LRVAEDPFYKQMAADCTKFQIGINVYAFSDKYTDIASLGTLAKYTGGQVYYYPGFQSSVHGDKLRHELAR 678
Cdd:pfam04811  160 HHGTDKEKAkLVKKADKFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADVDGSKFKQDLQR 239


                   ..
gi 30680129    679 DL 680
Cdd:pfam04811  240 YF 241
trunk_domain cd01468
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ...
 443-678 2.92e-101

trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.


Pssm-ID: 238745 [Multi-domain]  Cd Length: 239  Bit Score: 317.65  E-value: 2.92e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  443 PMPPIYFFLIDVSISATKSGMLEVVAQTIKSCLDNLPGYPRTQIGFITYDSTLHFYNMKSSLSQPQMMVVSDLDDIFVPL 522
Cdd:cd01468    1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGDPRARVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKDVFLPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  523 PDDLLVNLSESRTVVDAFLDSLPLMFQD--NFNVESAFGPALRAAFMVMNQL--GGKLLIFQNSLPSLGAGRLKLRgDDP 598
Cdd:cd01468   81 PDRFLVPLSECKKVIHDLLEQLPPMFWPvpTHRPERCLGPALQAAFLLLKGTfaGGRIIVFQGGLPTVGPGKLKSR-EDK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  599 RVYGTDKEYALRVAEDPFYKQMAADCTKFQIGINVYAFSDKYTDIASLGTLAKYTGGQVYYYPGFQSSVHGDKLRHELAR 678
Cdd:cd01468  160 EPIRSHDEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQAPNDGSKFKQDLQR 239
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 440-1037 2.52e-37

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 152.92  E-value: 2.52e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   440 VRPPMPPIYFFLIDVSISATKSGMLEVVAQTIKSCLDNLPgYPRTQIGFITYDSTLHFYNMKSSLSQP------------ 507
Cdd:PTZ00395  947 VKNMLPPYFVFVVECSYNAIYNNITYTILEGIRYAVQNVK-CPQTKIAIITFNSSIYFYHCKGGKGVSgeegdggggsgn 1025

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   508 -QMMVVSDLDDIFVPLP-DDLLVNLSESRTVVDAFLDSLPLMFQDNFNVESAFGPALRAAFMVMNQLGG--KLLIFQNSL 583
Cdd:PTZ00395 1026 hQVIVMSDVDDPFLPLPlEDLFFGCVEEIDKINTLIDTIKSVSTTMQSYGSCGNSALKIAMDMLKERNGlgSICMFYTTT 1105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   584 PSLGAGRLKLRGDDPrvygtdKEYALRVAEDPFYKQMAADCTKFQIGINVYAFSDKYTDIA--SLGTLAKYTGGQVYYYP 661
Cdd:PTZ00395 1106 PNCGIGAIKELKKDL------QENFLEVKQKIFYDSLLLDLYAFNISVDIFIISSNNVRVCvpSLQYVAQNTGGKILFVE 1179

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   662 GFQSSVHGDKLRHELARDLTRETaweavMRIRCGKGIRFSSY---------HGNF-MLRSTDLLALPAVDCDKAYAMQLS 731
Cdd:PTZ00395 1180 NFLWQKDYKEIYMNIMDTLTSED-----IAYCCELKLRYSHHmsvkklfccNNNFnSIISVDTIKIPKIRHDQTFAFLLN 1254

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   732 LEETLLTSQTVYFQVALLYTASCGERRIRVHTSVAPVVTDLGEMYRQADTGSIVSLYARLAIEKSLSAklDDARNAIQQK 811
Cdd:PTZ00395 1255 YSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTDAEALMNILIKQLCTNILHN--DNYSKIIIDN 1332

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   812 IVKALKEYR-NLHAVQHrlGSRLVYPESLKFLPLYGLAITKSTPLlggPADTSLDERCAAGFTMMALPVKKLLKLLYPNL 890
Cdd:PTZ00395 1333 LAAILFSYRiNCASSAH--SGQLILPDTLKLLPLFTSSLLKHNVT---KKEILHDLKVYSLIKLLSMPIISSLLYVYPVM 1407

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   891 FRVDewlLKPSAAHDDFKDV------LRRLPLAAESLDSRGLYIYDDGFRLVLWFGRMLSPDIAKNLLGvDFAADLSRVT 964
Cdd:PTZ00395 1408 YVIH---IKGKTNEIDSMDVdddlfiPKTIPSSAEKIYSNGIYLLDACTHFYLYFGFHSDANFAKEIVG-DIPTEKNAHE 1483

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30680129   965 FQEQENGMSKKLMRLVKKLRESD--PSYHPMCFLV-RQGEQPRegflLLRNLIEDQMGGSSGYVDWILQLHRQVQQ 1037
Cdd:PTZ00395 1484 LNLTDTPNAQKVQRIIKNLSRIHhfNKYVPLVMVApKSNEEEH----LISLCVEDKADKEYSYVNFLCFIHKLVHK 1555
Sec23_BS pfam08033
Sec23/Sec24 beta-sandwich domain;
685-769 1.54e-29

Sec23/Sec24 beta-sandwich domain;


Pssm-ID: 429794 [Multi-domain]  Cd Length: 86  Bit Score: 112.63  E-value: 1.54e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    685 AWEAVMRIRCGKGIRFSSYHGNFMLRS-TDLLALPAVDCDKAYAMQLSLEETLLTSQTVYFQVALLYTASCGERRIRVHT 763
Cdd:pfam08033    1 GFNAVLRVRTSKGLKVSGFIGNFVSRSsGDTWKLPSLDPDTSYAFEFDIDEPLPNGSNAYIQFALLYTHSSGERRIRVTT 80


                   ....*.
gi 30680129    764 SVAPVV 769
Cdd:pfam08033   81 VALPVT 86
Sec23_helical pfam04815
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ...
 780-879 1.71e-26

Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.


Pssm-ID: 461441 [Multi-domain]  Cd Length: 103  Bit Score: 104.51  E-value: 1.71e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    780 DTGSIVSLYARLAIEKSLSAKLDDARNAIQQKIVKALKEYRNLHAVQHRLGSrLVYPESLKFLPLYGLAITKSTPLLGGp 859
Cdd:pfam04815    1 DQEAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYCASSSSPGQ-LILPESLKLLPLYMLALLKSPALRGG- 78

                           90       100
                   ....*....|....*....|
gi 30680129    860 ADTSLDERCAAGFTMMALPV 879
Cdd:pfam04815   79 NSSPSDERAYARHLLLSLPV 98
zf-Sec23_Sec24 pfam04810
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
 368-405 1.05e-18

Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.


Pssm-ID: 461437 [Multi-domain]  Cd Length: 38  Bit Score: 80.18  E-value: 1.05e-18
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 30680129    368 IIRCRRCRTYVNPFVTFTDSGRKWRCNICSMLNDVPGE 405
Cdd:pfam04810    1 PVRCRRCRAYLNPFCQFDFGGKKWTCNFCGTRNPVPPE 38
PLN00162 PLN00162
transport protein sec23; Provisional
 321-498 1.18e-13

transport protein sec23; Provisional


Pssm-ID: 215083 [Multi-domain]  Cd Length: 761  Bit Score: 75.36  E-value: 1.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   321 LRLTTSAIPNSQSLASRWHLPLGAVVCPLAETPEgeeVPLIDFGStgiIRCRRCRTYVNPFVTFTDSGRKWRCNICSMLN 400
Cdd:PLN00162   12 VRMSWNVWPSSKIEASKCVIPLAALYTPLKPLPE---LPVLPYDP---LRCRTCRAVLNPYCRVDFQAKIWICPFCFQRN 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   401 DVPGEYFShldatgrRMDMDQRPEL--TKGSVEIIAPTEyMVRPPMPPIYFFLIDVSIS-----ATKSGMLEVVAQTIKS 473
Cdd:PLN00162   86 HFPPHYSS-------ISETNLPAELfpQYTTVEYTLPPG-SGGAPSPPVFVFVVDTCMIeeelgALKSALLQAIALLPEN 157

                         170       180
                  ....*....|....*....|....*
gi 30680129   474 CLdnlpgyprtqIGFITYDSTLHFY 498
Cdd:PLN00162  158 AL----------VGLITFGTHVHVH 172
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2-324 3.16e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 71.51  E-value: 3.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     2 GTENQGYPNFPARPA--SSPFASAPP---PGIPPQSGGPPTGSEAVGFRPFTPSASQPTRPFTASGPPPAPPVGTMRPGQ 76
Cdd:PHA03247 2747 GPATPGGPARPARPPttAGPPAPAPPaapAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG 2826

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    77 PSPFVSQIPGSRPPPPSSNSFPSPAYG---PPGGAPFQRFPSPPFPTTQNPPQGPPPPQTLAGHLSPPMSLRPQQPMAPv 153
Cdd:PHA03247 2827 PLPPPTSAQPTAPPPPPGPPPPSLPLGgsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP- 2905

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   154 AMGPPPQSTTSGLPGANAYPPATDYHMPARPGFQQSMPPVTPSYPGVGGSQPSFPGYPSKQVLQAPTP---FQTSQGPPG 230
Cdd:PHA03247 2906 ERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvprFRVPQPAPS 2985

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   231 --PPPVSSYPPHTGGFAQRPNMAAQQNLHPNYAPPP-------------------SNVQGLTEDFNSLSLSSIPGSLEPG 289
Cdd:PHA03247 2986 reAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPvslkqtlwppddtedsdadSLFDSDSERSDLEALDPLPPEPHDP 3065

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 30680129   290 LDHKSFPRPLDGDVE--PNSFAEMYPMNCHS----RYLRLT 324
Cdd:PHA03247 3066 FAHEPDPATPEAGAResPSSQFGPPPLSANAalsrRYVRST 3106
PHA03247 PHA03247
large tegument protein UL36; Provisional
 9-267 1.06e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.50  E-value: 1.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     9 PNFPARPASSP-------FASAPPPGIPPQSGgPPTGSEAVGFRPFTPSASQPTRPFTASGPPPAPPVGTMRPGQPSPFV 81
Cdd:PHA03247 2680 PQRPRRRAARPtvgsltsLADPPPPPPTPEPA-PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA 2758

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    82 SqiPGSRPPPPSSNSFPSPAYGPP---------------GGAPFQRFPSPPFPTTQNPPQGPPPPQTLAGHLSPPMSLRP 146
Cdd:PHA03247 2759 R--PPTTAGPPAPAPPAAPAAGPPrrltrpavaslsesrESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP 2836

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   147 QQPmaPVAMGPPPQSTTSG-------------LPGANAYPPATDYHMPARpgfQQSMPPVTPSYPGVGGSQPSFPGYPSK 213
Cdd:PHA03247 2837 TAP--PPPPGPPPPSLPLGgsvapggdvrrrpPSRSPAAKPAAPARPPVR---RLARPAVSRSTESFALPPDQPERPPQP 2911

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 30680129   214 QVLQAPTPFQTSQGPPGPPPVSSYPPhtggfaqRPNMAAQQNLHPNYAPPPSNV 267
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPPQPQPPPPPPP-------RPQPPLAPTTDPAGAGEPSGA 2958
PHA03247 PHA03247
large tegument protein UL36; Provisional
 6-221 1.40e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.18  E-value: 1.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     6 QGYPNFPARPASSPFASAP-------PPGIPPQSGGPPTGseavgfrpfTPSASQPTRPFTASGPPPAPPVGTMRPGQPS 78
Cdd:PHA03247 2730 QASPALPAAPAPPAVPAGPatpggpaRPARPPTTAGPPAP---------APPAAPAAGPPRRLTRPAVASLSESRESLPS 2800

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    79 PFVSQIPGSRPPPPSSNSFPSPAYGPPGGAPFQRFPSPPFPTTQNPPQGPPPPQTLAghlsppmslrpqqPMAPVAMGPP 158
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVA-------------PGGDVRRRPP 2867

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30680129   159 PQSTTSgLPGANAYPPATDYHMPA--RPGFQQSMPPVTPSYPGVGGSQPSFPGYPSKQVLQAPTP 221
Cdd:PHA03247 2868 SRSPAA-KPAAPARPPVRRLARPAvsRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931
SEC23 COG5047
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
321-498 1.70e-08

Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];


Pssm-ID: 227380 [Multi-domain]  Cd Length: 755  Bit Score: 58.74  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  321 LRLTTSAIPNSQSLASRWHLPLGAVVCPLAETPEGEEVPLIDfgstgiIRCRR-CRTYVNPFVTFTDSGRKWRCNICSML 399
Cdd:COG5047   12 IRLTWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYYEP------VKCTApCKAVLNPYCHIDERNQSWICPFCNQR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129  400 NDVPGEYfshLDATGRRMDMDQRPELTkgSVEIIAPteymvRPP-MPPIYFFLIDVsisATKSGMLEVVAQTIKSCLDNL 478
Cdd:COG5047   86 NTLPPQY---RDISNANLPLELLPQSS--TIEYTLS-----KPViLPPVFFFVVDA---CCDEEELTALKDSLIVSLSLL 152

                        170       180
                 ....*....|....*....|
gi 30680129  479 PgyPRTQIGFITYDSTLHFY 498
Cdd:COG5047  153 P--PEALVGLITYGTSIQVH 170
PHA03247 PHA03247
large tegument protein UL36; Provisional
 7-220 5.60e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 5.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     7 GYPNFPARPASSPFASAPPPGIPPQSGGPPTgSEAVGFRPFTPS--ASQPTRPFTASGPPPAPPVGTMRPGQPSPF--VS 82
Cdd:PHA03247 2590 DAPPQSARPRAPVDDRGDPRGPAPPSPLPPD-THAPDPPPPSPSpaANEPDPHPPPTVPPPERPRDDPAPGRVSRPrrAR 2668

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    83 QIPGSRPPPPSSNSFPSPAYGPPGG--APFQRFPSP-----PFPTTQNPPQGPPPPQTLAGHLSPPMSLRPQQPMAPVAM 155
Cdd:PHA03247 2669 RLGRAAQASSPPQRPRRRAARPTVGslTSLADPPPPpptpePAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGP 2748

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30680129   156 GPPPQSTTSGLPGANAYPPAtdyhmPARPGFQQSMPPVTPSYPGVGGSQPSFPGYPSKQVLQAPT 220
Cdd:PHA03247 2749 ATPGGPARPARPPTTAGPPA-----PAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPP 2808
PHA03247 PHA03247
large tegument protein UL36; Provisional
 7-248 1.80e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 1.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     7 GYPNFPARPASSPFASAPPPgiPPQSGGPPTGSEAVGfrPFTPSASQPTRPFTASGPPPA-PPVGTMRPGQPSPFVSQIP 85
Cdd:PHA03247 2606 GDPRGPAPPSPLPPDTHAPD--PPPPSPSPAANEPDP--HPPPTVPPPERPRDDPAPGRVsRPRRARRLGRAAQASSPPQ 2681

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    86 GSRPPPPSSNSFPSPAYGPPggAPFQRFPSPPfPTTQNPPQGPPPPQTLAGHLSPPMSLRPQQPMAPVAMGPPPQSTTSG 165
Cdd:PHA03247 2682 RPRRRAARPTVGSLTSLADP--PPPPPTPEPA-PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA 2758

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   166 LPGANAYPPAtdyhmPARPGFQQSMPPVTPSYPGVGGSQPSFPGYPSKQ-------VLQAPTPFQTSQGPPGPP------ 232
Cdd:PHA03247 2759 RPPTTAGPPA-----PAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWdpadppaAVLAPAAALPPAASPAGPlpppts 2833

                         250
                  ....*....|....*.
gi 30680129   233 PVSSYPPHTGGFAQRP 248
Cdd:PHA03247 2834 AQPTAPPPPPGPPPPS 2849
PHA03247 PHA03247
large tegument protein UL36; Provisional
 10-305 3.08e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 3.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    10 NFPARPASSPFASAPPPGIPPQSGGPPTgseavgfRPFTPSASQPTRPFTASGPPPAPPvgtmRPGQPSPfvsqipgsrp 89
Cdd:PHA03247 2654 DDPAPGRVSRPRRARRLGRAAQASSPPQ-------RPRRRAARPTVGSLTSLADPPPPP----PTPEPAP---------- 2712

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    90 pppssnSFPSPAYGPPGGAPFQRFPSPPFPTTQNPPQGPPPPQTLAG---HLSPPMSLRPQQPMAPVAMGPPPQSTTSGL 166
Cdd:PHA03247 2713 ------HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGparPARPPTTAGPPAPAPPAAPAAGPPRRLTRP 2786

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   167 PGANAYPPATDyhMPARPGFQQSMPPVTPSYPGVGGSQPSFPGYPSKQVLQAPTPFQTSQGPPGPPPVSSYPPHTGGFAQ 246
Cdd:PHA03247 2787 AVASLSESRES--LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRR 2864

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 30680129   247 RPnmaaqqnlhPNYAPPPSNVQGLTEDFNSLSLSSIPGSLEPgldhksFPRPLDGDVEP 305
Cdd:PHA03247 2865 RP---------PSRSPAAKPAAPARPPVRRLARPAVSRSTES------FALPPDQPERP 2908
PHA03247 PHA03247
large tegument protein UL36; Provisional
 12-221 5.51e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 5.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    12 PARPASSPF-----ASAPPPGIPPQSGGPPTgseAVGFRPFTPSASQPTRPFTASGPPPAPPVGtmrpgqPSPFVSQIPG 86
Cdd:PHA03247 2570 PPRPAPRPSepavtSRARRPDAPPQSARPRA---PVDDRGDPRGPAPPSPLPPDTHAPDPPPPS------PSPAANEPDP 2640

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    87 SRPPPPSSNSFPSPAYGPPGGAPFQRFPSPPFPTTQNPPQGPPPPQTLAGHLSPPMSL-RPQQPMAPVAMGPPPQSTTSG 165
Cdd:PHA03247 2641 HPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLaDPPPPPPTPEPAPHALVSATP 2720

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 30680129   166 LPGANAYPPATDYHMPARPgfqqsMPPVTPSYPGVGGSQPSFPGYPSKQVLQAPTP 221
Cdd:PHA03247 2721 LPPGPAAARQASPALPAAP-----APPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771
Gelsolin pfam00626
Gelsolin repeat;
915-980 6.58e-07

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 47.69  E-value: 6.58e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    915 PLAAESLDSRGLYIYDDGFRLVLWFGRMlsPDIAKNLLGVDFAADLS---RVTFQEQEN-GMSKKLMRLV 980
Cdd:pfam00626    9 PLSQESLNSGDCYLLDNGFTIFLWVGKG--SSLLEKLFAALLAAQLDddeRFPLPEVIRvPQGKEPARFL 76
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 6-359 6.47e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.54  E-value: 6.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129      6 QGYPnfPARPASSPFASAPPPGIPPQ----SGGPPTGSEAVGFRPFTPSASQPTRPFTASGP----------------PP 65
Cdd:pfam03154  168 QTQP--PVLQAQSGAASPPSPPPPGTtqaaTAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPhtliqqtptlhpqrlpSP 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     66 APPVGTMRPGQPSPFVSqipgsrppPPSSNSFPSPAYGPPGGAPFQRFPS----------------------PPFPTTQN 123
Cdd:pfam03154  246 HPPLQPMTQPPPPSQVS--------PQPLPQPSLHGQMPPMPHSLQTGPShmqhpvppqpfpltpqssqsqvPPGPSPAA 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    124 PPQGPPPPQTLAGHLSPPMSLRPQQ---PMAPVAM---GPPPQSTTSGLPGANA--YPPatdyHMPARPGFQQSM----P 191
Cdd:pfam03154  318 PGQSQQRIHTPPSQSQLQSQQPPREqplPPAPLSMphiKPPPTTPIPQLPNPQShkHPP----HLSGPSPFQMNSnlppP 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    192 PVTPSYPGVGGSQPSFPGYPSKQVLQAPTPFQTSQgppgpppvssypphtggfAQRPNMAAQQNLHPNYAPPPSnvqglt 271
Cdd:pfam03154  394 PALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPP------------------AQPPVLTQSQSLPPPAASHPP------ 449

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    272 edfnslslssiPGSLEPGLDHKSFPR-PLDGDVEPNSFAEMYPMNCHSRylRLTTSAIPNSQSLASRWHLPlGAVVCPLA 350
Cdd:pfam03154  450 -----------TSGLHQVPSQSPFPQhPFVPGGPPPITPPSGPPTSTSS--AMPGIQPPSSASVSSSGPVP-AAVSCPLP 515


                   ....*....
gi 30680129    351 ETPEGEEVP 359
Cdd:pfam03154  516 PVQIKEEAL 524
PHA03378 PHA03378
EBNA-3B; Provisional
 9-221 1.45e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 49.30  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     9 PNFPARPASSPFAS--APPPGIPPQSGgpPTGSEAVGFRPFTPSASQPTRPFTASGPPPAPPVGTMRPGQPSPFVSQIPG 86
Cdd:PHA03378  651 PHQPPQVEITPYKPtwTQIGHIPYQPS--PTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPA 728

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    87 SRPPPPSSNSFPSPAYGPPGGAPFQRFPSPPFPTTQNPPQGPPPPQTlaghlspPMslrpQQPMAPVAMGPPPQSTTSGL 166
Cdd:PHA03378  729 AAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPT-------PQ----PPPQAPPAPQQRPRGAPTPQ 797

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 30680129   167 PGANAYPPATDYHMPARPGFQQSMPPVTPSY--PGVGGSQPS--FPGYPSKQVLQAPTP 221
Cdd:PHA03378  798 PPPQAGPTSMQLMPRAAPGQQGPTKQILRQLltGGVKRGRPSlkKPAALERQAAAGPTP 856
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 9-206 2.61e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.98  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     9 PNFPARPASSPFASAPPPgiPPQSGGPPTGSEAVGFRPFTPSASQPTRPFTASGPPPAPPVGTMRPGQPSPfvsqipgsr 88
Cdd:PRK07764  609 PEEAARPAAPAAPAAPAA--PAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA--------- 677

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    89 ppppssnsfpSPAYGPPGGAPFQRFPSPPFPttqnppQGPPPPQTLAGHLSPPMSLRPQQPMAPVAMGPPPQSTTSGLPg 168
Cdd:PRK07764  678 ----------PAAPPPAPAPAAPAAPAGAAP------AQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVP- 740

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 30680129   169 anaYPPATDYHMPARPGFQQSMPPVTPSYPGVGGSQPS 206
Cdd:PRK07764  741 ---LPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPP 775
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
12-253 2.75e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.87  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    12 PARPASSPFASAPPPGIPPQSGGPPtgseavgfrpftPSASQPTRPFTASGPPPAPPVGTMrPGQPSPfvsqipgsRPPP 91
Cdd:PRK12323  374 PATAAAAPVAQPAPAAAAPAAAAPA------------PAAPPAAPAAAPAAAAAARAVAAA-PARRSP--------APEA 432

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    92 PSSNSFPSPAYGPPGGAPFQRFPSPPFPTTQNPPQGPPPPQTLAGhlSPPMSLRPQQPMAPVAMGPPPQSTtsgLPGANA 171
Cdd:PRK12323  433 LAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAA--AAPARAAPAAAPAPADDDPPPWEE---LPPEFA 507

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   172 YP-PATDYHMPARPGFQQSMPPVTPSYPGVGGSQPSFPGYPSKQVLQAPTPFQTSQGPPGPPPVSSYPPHTGGFaqrPNM 250
Cdd:PRK12323  508 SPaPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDW---PAL 584


                  ...
gi 30680129   251 AAQ 253
Cdd:PRK12323  585 AAR 587
PHA03377 PHA03377
EBNA-3C; Provisional
 9-297 1.02e-03

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 43.12  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     9 PNFPARPASSPFASAPPPGIPPQSGGPPTGSEAVGFRPFTPSASQPTRpftaSGPPPAPPvGTMRPGQPSPFVsqipgsr 88
Cdd:PHA03377  557 PSDRGPPKASPPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAKCK----DGPPASGP-HEKQPPSSAPRD------- 624

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    89 ppppssnsfpspaYGPPGGAPFQRFPSPPFPTTQNPPQGPPPPqtlAGHLSPPMSLRPQQPMAPVAMGPPPQSTTsgLPG 168
Cdd:PHA03377  625 -------------MAPSVVRMFLRERLLEQSTGPKPKSFWEMR---AGRDGSGIQQEPSSRRQPATQSTPPRPSW--LPS 686

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   169 ANAYP--PATDyhmpARPGFQQSMPPVTPSYPGVGGSQPSF--PGYP---SKQVLQAPTPfqtsqgppgpppvssypPHT 241
Cdd:PHA03377  687 VFVLPsvDAGR----AQPSEESHLSSMSPTQPISHEEQPRYedPDDPldlSLHPDQAPPP-----------------SHQ 745

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   242 GGFAQRPNMAAQQNLHPNY---APPPSNVQGLTE-DFNSLSLSSIPGSLEPGLDHKSFPR 297
Cdd:PHA03377  746 APYSGHEEPQAQQAPYPGYwepRPPQAPYLGYQEpQAQGVQVSSYPGYAGPWGLRAQHPR 805
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
8-175 1.02e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     8 YPNFPARPASSPfASAPPPGIPPQSGGPPTGSEAVGFRPFTPSA------SQPTRPFTASGPPPAP---PVGTMRPGQPS 78
Cdd:PRK12323  390 AAPAAAAPAPAA-PPAAPAAAPAAAAAARAVAAAPARRSPAPEAlaaarqASARGPGGAPAPAPAPaaaPAAAARPAAAG 468

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    79 PfVSQIPGSRPPPPSSNSFPSPAYGPPGGAPFQR----FPSPPFPTTQNPPQGPPPPQTLAGHLSPPMSLRPQQPMAPVA 154
Cdd:PRK12323  469 P-RPVAAAAAAAPARAAPAAAPAPADDDPPPWEElppeFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAA 547

                         170       180
                  ....*....|....*....|.
gi 30680129   155 mGPPPQSTTSGLPGANAYPPA 175
Cdd:PRK12323  548 -APAPRAAAATEPVVAPRPPR 567
PHA03378 PHA03378
EBNA-3B; Provisional
 6-221 1.32e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.75  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     6 QGYPNFPARPASSPFASAPPPGIP---------PQSGGPPTGSEAVGFRP------FTPSASQPTRPfTASGPPPAPPVG 70
Cdd:PHA03378  708 AAPPGRAQRPAAATGRARPPAAAPgrarppaaaPGRARPPAAAPGRARPPaaapgrARPPAAAPGAP-TPQPPPQAPPAP 786

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    71 TMRP-GQPSPfvsqipgsrppppssnsfpspaYGPPGGAPFQRFPSPPFPTTQNPPQGPPPPQTLAGHLSP--PMSLRPQ 147
Cdd:PHA03378  787 QQRPrGAPTP----------------------QPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRgrPSLKKPA 844

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   148 --QPMAPVAMGPPPQSTTSG--LPGANAYPPA-TDYHMPARPGFQQSM-----PPVTPSYPG---VGGSQPSFPGYPSKQ 214
Cdd:PHA03378  845 alERQAAAGPTPSPGSGTSDkiVQAPVFYPPVlQPIQVMRQLGSVRAAaastvTQAPTEYTGerrGVGPMHPTDIPPSKR 924


                  ....*..
gi 30680129   215 VLQAPTP 221
Cdd:PHA03378  925 AKTDAYV 931
PHA03377 PHA03377
EBNA-3C; Provisional
 9-195 1.48e-03

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 42.73  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     9 PNFPARPASSPFASAPPPGIPPQSGgpptgseavgfRPFTPSASQPTRPFTASGPPPAPPVG-----------TMRPGQP 77
Cdd:PHA03377  726 PDDPLDLSLHPDQAPPPSHQAPYSG-----------HEEPQAQQAPYPGYWEPRPPQAPYLGyqepqaqgvqvSSYPGYA 794

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    78 SPFVSQIPGSRPPPPSSNSFPSPAYGPPGGAPFQRFPSPPfPTTQNPPQGPPPPQTLAGHLSP-PMSLRPQQPMAPVAMG 156
Cdd:PHA03377  795 GPWGLRAQHPRYRHSWAYWSQYPGHGHPQGPWAPRPPHLP-PQWDGSAGHGQDQVSQFPHLQSeTGPPRLQLSQVPQLPY 873

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 30680129   157 PPPQSTTSGLPGANAYPPAtdyhmPARPGFQQSMPPVTP 195
Cdd:PHA03377  874 SQTLVSSSAPSWSSPQPRA-----PIRPIPTRFPPPPMP 907
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 15-194 2.44e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.95  E-value: 2.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     15 PASSPFASAPPPGIPPQSGGPPTGSEAV--------GFRPFTPSASQPTRPFTASGPPPAPPVGTMRPGQPSPFVSQIPG 86
Cdd:pfam09770  166 APKKAAAPAPAPQPAAQPASLPAPSRKMmsleeveaAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQ 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     87 SRPPPPSSNsfpspaYGPPGGAPFQRFPSPPFPTTQNPPQGPPPPQTLAGHLSPPMSLRPQQPMAPVAMGPPPQSTTSGL 166
Cdd:pfam09770  246 PQQQPQQPQ------QHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQN 319

                          170       180
                   ....*....|....*....|....*...
gi 30680129    167 PGANAYPPATDYHMPARPGFQQSMPPVT 194
Cdd:pfam09770  320 PQPGVQPAPAHQAHRQQGSFGRQAPIIT 347
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1-265 2.51e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129     1 MGTENQGYPNFPARPASSPFA---SAPPPGIPPQSGGPPTGSEAVgfRPFTPSasQPTRPFTASGPPPAPPvgtmRPGQP 77
Cdd:PHA03247 2543 LASDDAGDPPPPLPPAAPPAApdrSVPPPRPAPRPSEPAVTSRAR--RPDAPP--QSARPRAPVDDRGDPR----GPAPP 2614

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    78 SPFvsqipgsrppppssnsfpspaygPPGGAPfqrfPSPPFPTTQNPPQGPPPPQTLAGhlspPMSLRPQQPMAPVAMGP 157
Cdd:PHA03247 2615 SPL-----------------------PPDTHA----PDPPPPSPSPAANEPDPHPPPTV----PPPERPRDDPAPGRVSR 2663

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   158 PPQSTTSGLPGANAYPPatdyHMPARPGFQQSMPPVTPSypgvggSQPSFPGypskqvlqaPTPfqtsqgppgpppVSSY 237
Cdd:PHA03247 2664 PRRARRLGRAAQASSPP----QRPRRRAARPTVGSLTSL------ADPPPPP---------PTP------------EPAP 2712

                         250       260       270
                  ....*....|....*....|....*....|..
gi 30680129   238 PPHTGGFAQRPNMAAQQNLHP----NYAPPPS 265
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQASPalpaAPAPPAV 2744
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 13-221 3.10e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 41.59  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   13 ARPASSPFASAPPPGIPPQSGGPPTGSEAVGFRPFTPSASQPTRPF--TASGPPPAPPV--GTMRPGQPSPFVSQIPGSR 88
Cdd:COG5180  224 PRPEAASSPKVDPPSTSEARSRPATVDAQPEMRPPADAKERRRAAIgdTPAAEPPGLPVleAGSEPQSDAPEAETARPID 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   89 PPPPssnsfpspAYGPPGGAPFQRFPSPPFPTTQNPPQGPPPPQTLAGHLS----PPMSLRPQQPMAPVAMGPP--PQST 162
Cdd:COG5180  304 VKGV--------ASAPPATRPVRPPGGARDPGTPRPGQPTERPAGVPEAASdagqPPSAYPPAEEAVPGKPLEQgaPRPG 375

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30680129  163 TSGLPGANAYPP-ATDYHMPARPGFQ-QSMPPVTPSYPGVGGSQPSF--PGYPSKQVLQAPTP 221
Cdd:COG5180  376 SSGGDGAPFQPPnGAPQPGLGRRGAPgPPMGAGDLVQAALDGGGRETasLGGAAGGAGQGPKA 438
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 29-221 3.21e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.51  E-value: 3.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    29 PPQSGGPPTGSEAVGFRPFTPSASQPtrpftASGPPPAPPVGTMRPGQPspfvsqipgsrppppssnsfpspayGPPGGA 108
Cdd:PRK07764  590 PAPGAAGGEGPPAPASSGPPEEAARP-----AAPAAPAAPAAPAPAGAA-------------------------AAPAEA 639

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129   109 PFQRFPSPPFPTTQNPPQGPPPPQTlaghlSPPMSLRPQQPMAPVAMGPPPQSTTSGLPGANAYPPATDYHMPARPGFQQ 188
Cdd:PRK07764  640 SAAPAPGVAAPEHHPKHVAVPDASD-----GGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQA 714

                         170       180       190
                  ....*....|....*....|....*....|...
gi 30680129   189 SMPPVTPSYPGVGGSQPsfPGYPSKQVLQAPTP 221
Cdd:PRK07764  715 DDPAAQPPQAAQGASAP--SPAADDPVPLPPEP 745
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 12-79 6.01e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 6.01e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30680129    12 PARPASSPFASAPPPGIPPQSGGPPTGSEAVGFRPFTPSASQPTRPFTASGPPPAPPVGTMRPGQPSP 79
Cdd:PRK07764  417 PAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAP 484
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 130-273 6.10e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.79  E-value: 6.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30680129    130 PPQTLAGHLSPPMSLRPQQPMAPVAMGPPPQSTTSGLPGANAYPPATDYHMPARPGFQQSMPPVTPSYPGVGGSQPSFPG 209
Cdd:pfam09770  218 PAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPV 297

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30680129    210 YPSkQVLQAPTPFQTSQGPPGPPPVSSYPPHTGGFAQRpnmaaQQNLHPNYAPP---PSNVQGLTED 273
Cdd:pfam09770  298 QPT-QILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHR-----QQGSFGRQAPIithPQQLAQLSEE 358
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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