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Conserved domains on  [gi|15229973|ref|NP_187187|]
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receptor like protein 30 [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1000136)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 14-714 2.12e-70

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 249.38  E-value: 2.12e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973   14 ITLYFFLLgslvlrtLASSRLHycrHDQRDALLEFKhefpVSESKPSPSLSSWNKTSDCCFWEGVTCDDESgEVVSLDLS 93
Cdd:PLN00113  13 IFMLFFLF-------LNFSMLH---AEELELLLSFK----SSINDPLKYLSNWNSSADVCLWQGITCNNSS-RVVSIDLS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973   94 YVllNNSLKPTSGLFKLQQLQNLTLSDCHLYGEV-------TSSL----------------GNLSRLTHLDLSSNQLTGE 150
Cdd:PLN00113  78 GK--NISGKISSAIFRLPYIQTINLSNNQLSGPIpddifttSSSLrylnlsnnnftgsiprGSIPNLETLDLSNNMLSGE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  151 VLASVSKLNQLRDLLLSENSFSGNIPTSFTNLTKLSSLDISSNQFTLEnFSFILPNLTSLSSLNVASNHFKSTLPSDMSG 230
Cdd:PLN00113 156 IPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQ-IPRELGQMKSLKWIYLGYNNLSGEIPYEIGG 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  231 LHNLKYFDVRENSFVGTFPTSLFTIPSLQIVYLEGNQFMGPIKfGNISSSSRLWDLNLADNKFDGPIPEYISEIHSLIVL 310
Cdd:PLN00113 235 LTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIP-PSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEIL 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  311 DLSHNNLVGPIPTSISKLVNLQHLSLSNNTLEGEVPGCLWglmtvtlSHNSFNSfgksssgaldgesmqeLDLGSNSLGG 390
Cdd:PLN00113 314 HLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLG-------KHNNLTV----------------LDLSTNNLTG 370

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  391 PFPHWICKQRFLKYLDLSNNLFNGSIPPCLKNSTYwLKGLVLRNNSFSGFLPDVFVNASMLLSLDVSYNRLEGKLPKSli 470
Cdd:PLN00113 371 EIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRS-LRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSR-- 447

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  471 nctgmellnvgsniikdtfpSWlvSLPSLRVLILRSNAFYGSLyydHISFGFQHLRLIDISQNGFSGTLsPLYFSNWREM 550
Cdd:PLN00113 448 --------------------KW--DMPSLQMLSLARNKFFGGL---PDSFGSKRLENLDLSRNQFSGAV-PRKLGSLSEL 501

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  551 VTsvleengsnigtedwymgekgpefshsnsmtmiykgvetdflripyffraIDFSGNRFFGNIPESVGLLKELRLLNLS 630
Cdd:PLN00113 502 MQ--------------------------------------------------LKLSENKLSGEIPDELSSCKKLVSLDLS 531

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  631 GNSFTSNIPQSLANLTNLETLDLSRNQLSGHIPRDLGSLSFLSTMNFSHNLLEGPVPLGTQFQSQHCSTFMDNLRLYGLE 710
Cdd:PLN00113 532 HNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPSTGAFLAINASAVAGNIDLCGGD 611


                 ....
gi 15229973  711 KICG 714
Cdd:PLN00113 612 TTSG 615
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 14-714 2.12e-70

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 249.38  E-value: 2.12e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973   14 ITLYFFLLgslvlrtLASSRLHycrHDQRDALLEFKhefpVSESKPSPSLSSWNKTSDCCFWEGVTCDDESgEVVSLDLS 93
Cdd:PLN00113  13 IFMLFFLF-------LNFSMLH---AEELELLLSFK----SSINDPLKYLSNWNSSADVCLWQGITCNNSS-RVVSIDLS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973   94 YVllNNSLKPTSGLFKLQQLQNLTLSDCHLYGEV-------TSSL----------------GNLSRLTHLDLSSNQLTGE 150
Cdd:PLN00113  78 GK--NISGKISSAIFRLPYIQTINLSNNQLSGPIpddifttSSSLrylnlsnnnftgsiprGSIPNLETLDLSNNMLSGE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  151 VLASVSKLNQLRDLLLSENSFSGNIPTSFTNLTKLSSLDISSNQFTLEnFSFILPNLTSLSSLNVASNHFKSTLPSDMSG 230
Cdd:PLN00113 156 IPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQ-IPRELGQMKSLKWIYLGYNNLSGEIPYEIGG 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  231 LHNLKYFDVRENSFVGTFPTSLFTIPSLQIVYLEGNQFMGPIKfGNISSSSRLWDLNLADNKFDGPIPEYISEIHSLIVL 310
Cdd:PLN00113 235 LTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIP-PSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEIL 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  311 DLSHNNLVGPIPTSISKLVNLQHLSLSNNTLEGEVPGCLWglmtvtlSHNSFNSfgksssgaldgesmqeLDLGSNSLGG 390
Cdd:PLN00113 314 HLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLG-------KHNNLTV----------------LDLSTNNLTG 370

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  391 PFPHWICKQRFLKYLDLSNNLFNGSIPPCLKNSTYwLKGLVLRNNSFSGFLPDVFVNASMLLSLDVSYNRLEGKLPKSli 470
Cdd:PLN00113 371 EIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRS-LRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSR-- 447

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  471 nctgmellnvgsniikdtfpSWlvSLPSLRVLILRSNAFYGSLyydHISFGFQHLRLIDISQNGFSGTLsPLYFSNWREM 550
Cdd:PLN00113 448 --------------------KW--DMPSLQMLSLARNKFFGGL---PDSFGSKRLENLDLSRNQFSGAV-PRKLGSLSEL 501

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  551 VTsvleengsnigtedwymgekgpefshsnsmtmiykgvetdflripyffraIDFSGNRFFGNIPESVGLLKELRLLNLS 630
Cdd:PLN00113 502 MQ--------------------------------------------------LKLSENKLSGEIPDELSSCKKLVSLDLS 531

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  631 GNSFTSNIPQSLANLTNLETLDLSRNQLSGHIPRDLGSLSFLSTMNFSHNLLEGPVPLGTQFQSQHCSTFMDNLRLYGLE 710
Cdd:PLN00113 532 HNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPSTGAFLAINASAVAGNIDLCGGD 611


                 ....
gi 15229973  711 KICG 714
Cdd:PLN00113 612 TTSG 615
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-435 2.12e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.62  E-value: 2.12e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  87 VVSLDLSYVLLNNSLKPTSGLFKLQQLQNLTLSDCHLYGEVTSSLGNLSRLTHLDLSSNQLTGEVLASVSKLNQLRDLLL 166
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 167 SENSFsgNIPTSFTNLTKLSSLDISSNQFtlenfsfiLPNLTSLSSLNVASNHFKStLPSDMSGLHNLKYFDVRENSFvG 246
Cdd:COG4886  82 LSLLL--LGLTDLGDLTNLTELDLSGNEE--------LSNLTNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQL-T 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 247 TFPTSLFTIPSLQIVYLEGNQFMG-PIKFGNISSssrLWDLNLADNKFDgPIPEYISEIHSLIVLDLSHNNLvGPIPTSI 325
Cdd:COG4886 150 DLPEPLGNLTNLKSLDLSNNQLTDlPEELGNLTN---LKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQL-TDLPEPL 224

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 326 SKLVNLQHLSLSNNTLEgEVP--GCLWGLMTVTLSHNSFNSFGKSSsgalDGESMQELDLGSNSLGGPFPHWICKQRFLK 403
Cdd:COG4886 225 ANLTNLETLDLSNNQLT-DLPelGNLTNLEELDLSNNQLTDLPPLA----NLTNLKTLDLSNNQLTDLKLKELELLLGLN 299

                       330       340       350
                ....*....|....*....|....*....|..
gi 15229973 404 YLDLSNNLFNGSIPPCLKNSTYWLKGLVLRNN 435
Cdd:COG4886 300 SLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 40-81 1.18e-09

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 54.22  E-value: 1.18e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15229973    40 DQRDALLEFKHEFpvseSKPSPSLSSWN-KTSDCCFWEGVTCD 81
Cdd:pfam08263   3 DDGQALLAFKSSL----NDPPGALSSWNsSSSDPCSWTGVTCD 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 131-287 3.45e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 3.45e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 131 LGNLSRLTHLDLSSNQLtgEVLASVSKLNQLRDLLLSENSFS---GniptsFTNLTKLSSLDIS------SNQFTLENFS 201
Cdd:cd21340  42 LEFLTNLTHLYLQNNQI--EKIENLENLVNLKKLYLGGNRISvveG-----LENLTNLEELHIEnqrlppGEKLTFDPRS 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 202 fILPNLTSLSSLNVASNHFKStlPSDMSGLHNLKYFDVRENSF--VGTFPTSLFTIPSLQIVYLEGNQFMGPIKFGN--I 277
Cdd:cd21340 115 -LAALSNSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQIsdLEELLDLLSSWPSLRELDLTGNPVCKKPKYRDkiI 191

                       170
                ....*....|
gi 15229973 278 SSSSRLWDLN 287
Cdd:cd21340 192 LASKSLEVLD 201
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 14-714 2.12e-70

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 249.38  E-value: 2.12e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973   14 ITLYFFLLgslvlrtLASSRLHycrHDQRDALLEFKhefpVSESKPSPSLSSWNKTSDCCFWEGVTCDDESgEVVSLDLS 93
Cdd:PLN00113  13 IFMLFFLF-------LNFSMLH---AEELELLLSFK----SSINDPLKYLSNWNSSADVCLWQGITCNNSS-RVVSIDLS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973   94 YVllNNSLKPTSGLFKLQQLQNLTLSDCHLYGEV-------TSSL----------------GNLSRLTHLDLSSNQLTGE 150
Cdd:PLN00113  78 GK--NISGKISSAIFRLPYIQTINLSNNQLSGPIpddifttSSSLrylnlsnnnftgsiprGSIPNLETLDLSNNMLSGE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  151 VLASVSKLNQLRDLLLSENSFSGNIPTSFTNLTKLSSLDISSNQFTLEnFSFILPNLTSLSSLNVASNHFKSTLPSDMSG 230
Cdd:PLN00113 156 IPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQ-IPRELGQMKSLKWIYLGYNNLSGEIPYEIGG 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  231 LHNLKYFDVRENSFVGTFPTSLFTIPSLQIVYLEGNQFMGPIKfGNISSSSRLWDLNLADNKFDGPIPEYISEIHSLIVL 310
Cdd:PLN00113 235 LTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIP-PSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEIL 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  311 DLSHNNLVGPIPTSISKLVNLQHLSLSNNTLEGEVPGCLWglmtvtlSHNSFNSfgksssgaldgesmqeLDLGSNSLGG 390
Cdd:PLN00113 314 HLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLG-------KHNNLTV----------------LDLSTNNLTG 370

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  391 PFPHWICKQRFLKYLDLSNNLFNGSIPPCLKNSTYwLKGLVLRNNSFSGFLPDVFVNASMLLSLDVSYNRLEGKLPKSli 470
Cdd:PLN00113 371 EIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRS-LRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSR-- 447

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  471 nctgmellnvgsniikdtfpSWlvSLPSLRVLILRSNAFYGSLyydHISFGFQHLRLIDISQNGFSGTLsPLYFSNWREM 550
Cdd:PLN00113 448 --------------------KW--DMPSLQMLSLARNKFFGGL---PDSFGSKRLENLDLSRNQFSGAV-PRKLGSLSEL 501

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  551 VTsvleengsnigtedwymgekgpefshsnsmtmiykgvetdflripyffraIDFSGNRFFGNIPESVGLLKELRLLNLS 630
Cdd:PLN00113 502 MQ--------------------------------------------------LKLSENKLSGEIPDELSSCKKLVSLDLS 531

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  631 GNSFTSNIPQSLANLTNLETLDLSRNQLSGHIPRDLGSLSFLSTMNFSHNLLEGPVPLGTQFQSQHCSTFMDNLRLYGLE 710
Cdd:PLN00113 532 HNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLHGSLPSTGAFLAINASAVAGNIDLCGGD 611


                 ....
gi 15229973  711 KICG 714
Cdd:PLN00113 612 TTSG 615
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-435 2.12e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.62  E-value: 2.12e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  87 VVSLDLSYVLLNNSLKPTSGLFKLQQLQNLTLSDCHLYGEVTSSLGNLSRLTHLDLSSNQLTGEVLASVSKLNQLRDLLL 166
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 167 SENSFsgNIPTSFTNLTKLSSLDISSNQFtlenfsfiLPNLTSLSSLNVASNHFKStLPSDMSGLHNLKYFDVRENSFvG 246
Cdd:COG4886  82 LSLLL--LGLTDLGDLTNLTELDLSGNEE--------LSNLTNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQL-T 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 247 TFPTSLFTIPSLQIVYLEGNQFMG-PIKFGNISSssrLWDLNLADNKFDgPIPEYISEIHSLIVLDLSHNNLvGPIPTSI 325
Cdd:COG4886 150 DLPEPLGNLTNLKSLDLSNNQLTDlPEELGNLTN---LKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQL-TDLPEPL 224

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 326 SKLVNLQHLSLSNNTLEgEVP--GCLWGLMTVTLSHNSFNSFGKSSsgalDGESMQELDLGSNSLGGPFPHWICKQRFLK 403
Cdd:COG4886 225 ANLTNLETLDLSNNQLT-DLPelGNLTNLEELDLSNNQLTDLPPLA----NLTNLKTLDLSNNQLTDLKLKELELLLGLN 299

                       330       340       350
                ....*....|....*....|....*....|..
gi 15229973 404 YLDLSNNLFNGSIPPCLKNSTYWLKGLVLRNN 435
Cdd:COG4886 300 SLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
164-567 3.23e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 3.23e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 164 LLLSENSFSGNIPTSFTNLTKLSSLDISSNQFTLENFSFILPNLTSLSSLNVASNHFKSTLPSDM-SGLHNLKYFDVREN 242
Cdd:COG4886   3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLlLSLLLLLLLSLLLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 243 SFVGTFPTSLFTIPSLQIVYLEGNQfmgpikfgNISSSSRLWDLNLADNKFDGpIPEYISEIHSLIVLDLSHNNLvGPIP 322
Cdd:COG4886  83 SLLLLGLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQL-TDLP 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 323 TSISKLVNLQHLSLSNNTLEgEVPGCLWGLmtvtlshnsfnsfgksssgaldgESMQELDLGSNSLgGPFPHWICKQRFL 402
Cdd:COG4886 153 EPLGNLTNLKSLDLSNNQLT-DLPEELGNL-----------------------TNLKELDLSNNQI-TDLPEPLGNLTNL 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 403 KYLDLSNNLFNgSIPPCLKNSTyWLKGLVLRNNSFSGfLPDvFVNASMLLSLDVSYNRLEGkLPKSLiNCTGMELLNVGS 482
Cdd:COG4886 208 EELDLSGNQLT-DLPEPLANLT-NLETLDLSNNQLTD-LPE-LGNLTNLEELDLSNNQLTD-LPPLA-NLTNLKTLDLSN 281

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 483 NIIKDTFPSWLVSLPSLRVLILRSNAFYGSLYYDHISFGFQHLRLIDISQNGFSGTLSPLYFSNWREMVTSVLEENGSNI 562
Cdd:COG4886 282 NQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361


                ....*
gi 15229973 563 GTEDW 567
Cdd:COG4886 362 LLTLL 366
PLN03150 PLN03150
hypothetical protein; Provisional
 61-178 4.94e-14

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 75.62  E-value: 4.94e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973   61 PSLSSWNktSDCCF-----WEGVTC--DDESGEVVSLDLSyvLLNNSLKP--TSGLFKLQQLQNLTLSDCHLYGEVTSSL 131
Cdd:PLN03150 387 PLRFGWN--GDPCVpqqhpWSGADCqfDSTKGKWFIDGLG--LDNQGLRGfiPNDISKLRHLQSINLSGNSIRGNIPPSL 462

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 15229973  132 GNLSRLTHLDLSSNQLTGEVLASVSKLNQLRDLLLSENSFSGNIPTS 178
Cdd:PLN03150 463 GSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAA 509
PLN03150 PLN03150
hypothetical protein; Provisional
 276-363 1.51e-13

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 74.08  E-value: 1.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  276 NISSSSRLWDLNLADNKFDGPIPEYISEIHSLIVLDLSHNNLVGPIPTSISKLVNLQHLSLSNNTLEGEVPGCLWGLMtv 355
Cdd:PLN03150 437 DISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGRL-- 514


                 ....*...
gi 15229973  356 tLSHNSFN 363
Cdd:PLN03150 515 -LHRASFN 521
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-345 3.35e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 3.35e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  89 SLDLSyvllNNSLKP-TSGLFKLQQLQNLTLSDCHLyGEVTSSLGNLSRLTHLDLSSNQLTgEVLASVSKLNQLRDLLLS 167
Cdd:COG4886 163 SLDLS----NNQLTDlPEELGNLTNLKELDLSNNQI-TDLPEPLGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLS 236

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 168 ENSFSgNIPtSFTNLTKLSSLDISSNQFTleNFSFILpNLTSLSSLNVASNHFKSTLPSDMSGLHNL--KYFDVRENSFV 245
Cdd:COG4886 237 NNQLT-DLP-ELGNLTNLEELDLSNNQLT--DLPPLA-NLTNLKTLDLSNNQLTDLKLKELELLLGLnsLLLLLLLLNLL 311

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 246 GTFPTSLFTIPSLQIVYLEGNQFMGPIKFGNISSSSRLWDLNLADNKFDGPIPEYISEIHSLIVLDLSHNNLVGPIPTSI 325
Cdd:COG4886 312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391

                       250       260
                ....*....|....*....|
gi 15229973 326 SKLVNLQHLSLSNNTLEGEV 345
Cdd:COG4886 392 LLLTTTAGVLLLTLALLDAV 411
PLN03150 PLN03150
hypothetical protein; Provisional
 586-721 1.08e-10

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 65.22  E-value: 1.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  586 YKGVETDFLRIP--YFFRAIDFSGNRFFGNIPESVGLLKELRLLNLSGNSFTSNIPQSLANLTNLETLDLSRNQLSGHIP 663
Cdd:PLN03150 404 WSGADCQFDSTKgkWFIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIP 483

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15229973  664 RDLGSLSFLSTMNFSHNLLEGPVP--LGTQFQSQHCSTFMDNLRLYGLEKI--CGkAHAPSS 721
Cdd:PLN03150 484 ESLGQLTSLRILNLNGNSLSGRVPaaLGGRLLHRASFNFTDNAGLCGIPGLraCG-PHLSVG 544
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 40-81 1.18e-09

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 54.22  E-value: 1.18e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 15229973    40 DQRDALLEFKHEFpvseSKPSPSLSSWN-KTSDCCFWEGVTCD 81
Cdd:pfam08263   3 DDGQALLAFKSSL----NDPPGALSSWNsSSSDPCSWTGVTCD 41
PLN03150 PLN03150
hypothetical protein; Provisional
 140-231 1.68e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 57.90  E-value: 1.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  140 LDLSSNQLTGEVLASVSKLNQLRDLLLSENSFSGNIPTSFTNLTKLSSLDISSNQFtleNFSF--ILPNLTSLSSLNVAS 217
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSF---NGSIpeSLGQLTSLRILNLNG 499

                         90
                 ....*....|....
gi 15229973  218 NHFKSTLPSDMSGL 231
Cdd:PLN03150 500 NSLSGRVPAALGGR 513
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 131-287 3.45e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 3.45e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 131 LGNLSRLTHLDLSSNQLtgEVLASVSKLNQLRDLLLSENSFS---GniptsFTNLTKLSSLDIS------SNQFTLENFS 201
Cdd:cd21340  42 LEFLTNLTHLYLQNNQI--EKIENLENLVNLKKLYLGGNRISvveG-----LENLTNLEELHIEnqrlppGEKLTFDPRS 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 202 fILPNLTSLSSLNVASNHFKStlPSDMSGLHNLKYFDVRENSF--VGTFPTSLFTIPSLQIVYLEGNQFMGPIKFGN--I 277
Cdd:cd21340 115 -LAALSNSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQIsdLEELLDLLSSWPSLRELDLTGNPVCKKPKYRDkiI 191

                       170
                ....*....|
gi 15229973 278 SSSSRLWDLN 287
Cdd:cd21340 192 LASKSLEVLD 201
PLN03150 PLN03150
hypothetical protein; Provisional
 310-437 4.41e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 56.75  E-value: 4.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  310 LDLSHNNLVGPIPTSISKLVNLQHLSLSNNTLEGEVPGCLwGLMTvtlshnsfnsfgksssgaldgeSMQELDLGSNSLG 389
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSL-GSIT----------------------SLEVLDLSYNSFN 479

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 15229973  390 GPFPHWICKQRFLKYLDLSNNLFNGSIPPClknstywLKGLVLRNNSF 437
Cdd:PLN03150 480 GSIPESLGQLTSLRILNLNGNSLSGRVPAA-------LGGRLLHRASF 520
PLN03150 PLN03150
hypothetical protein; Provisional
 421-513 2.35e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 54.44  E-value: 2.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  421 KNSTYW-LKGLVLRNNSFSGFLPDVFVNASMLLSLDVSYNRLEGKLPKSLINCTGMELLNVGSNIIKDTFPSWLVSLPSL 499
Cdd:PLN03150 413 STKGKWfIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSL 492

                         90
                 ....*....|....
gi 15229973  500 RVLILRSNAFYGSL 513
Cdd:PLN03150 493 RILNLNGNSLSGRV 506
PLN03150 PLN03150
hypothetical protein; Provisional
 381-469 7.00e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.90  E-value: 7.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  381 LDLGSNSLGGPFPHWICKQRFLKYLDLSNNLFNGSIPPCLKNSTYwLKGLVLRNNSFSGFLPDVFVNASMLLSLDVSYNR 460
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITS-LEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNS 501


                 ....*....
gi 15229973  461 LEGKLPKSL 469
Cdd:PLN03150 502 LSGRVPAAL 510
PLN03150 PLN03150
hypothetical protein; Provisional
 279-393 8.83e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.51  E-value: 8.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  279 SSSRLW---DLNLADNKFDGPIPEYISEIHSLIVLDLSHNNLVGPIPTSISKLVNLQHLSLSNNTLEGEVPGCLwGLMTv 355
Cdd:PLN03150 413 STKGKWfidGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESL-GQLT- 490

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 15229973  356 tlshnsfnsfgksssgaldgeSMQELDLGSNSLGGPFP 393
Cdd:PLN03150 491 ---------------------SLRILNLNGNSLSGRVP 507
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
307-684 2.70e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 2.70e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 307 LIVLDLSHNNLVGPIPTSISKLVNLQHLSLSNNTLEGEVPGCLWGLMTVTLSHNSFNSFGKSSSGALDGESMQELDLGSN 386
Cdd:COG4886   3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 387 SLGGPFPHWICKQRFLKYLDLSNNLFNGSippcLKNstywLKGLVLRNNSFSGfLPDVFVNASMLLSLDVSYNRLEgKLP 466
Cdd:COG4886  83 SLLLLGLTDLGDLTNLTELDLSGNEELSN----LTN----LESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLT-DLP 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 467 KSLINCTGMELLNVGSNIIKDtFPSWLVSLPSLRVLILRSNafygslyydhisfgfqhlRLIDIsqngfsgtlsPLYFSN 546
Cdd:COG4886 153 EPLGNLTNLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNN------------------QITDL----------PEPLGN 203

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 547 WREMVTsvleengsnigtedwymgekgpefshsnsmtmiykgvetdflripyffraIDFSGNRFfgnipesvgllkelrl 626
Cdd:COG4886 204 LTNLEE--------------------------------------------------LDLSGNQL---------------- 217

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 15229973 627 lnlsgnsftSNIPQSLANLTNLETLDLSRNQLSgHIPrDLGSLSFLSTMNFSHNLLEG 684
Cdd:COG4886 218 ---------TDLPEPLANLTNLETLDLSNNQLT-DLP-ELGNLTNLEELDLSNNQLTD 264
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
272-688 8.01e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 8.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 272 IKFGNISSSSRLWDLNLADNKFDGPIPEYISEIHSLIVLDLSHNNLVGPIPTSISKLVNLQHLSLSNNTLEGEVPGCLWG 351
Cdd:COG4886  18 LELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTN 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 352 LMTVTLSHNSFNSfgksssgalDGESMQELDLGSNSLGGpFPHWICKQRFLKYLDLSNNLFNgSIPPCLKNSTYwLKGLV 431
Cdd:COG4886  98 LTELDLSGNEELS---------NLTNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLT-DLPEPLGNLTN-LKSLD 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 432 LRNNSFSGfLPDVFVNASMLLSLDVSYNRLEgKLPKSLINCTGMELLNVGSNIIKDtFPSWLVSLPSLRVLILRSNafyg 511
Cdd:COG4886 166 LSNNQLTD-LPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNN---- 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 512 slyydhisfgfqhlRLIDIsqngfsgtlsplyfsnwremvtsvleengsnigtedwymgekgPEFSHSNSMTMIykgvet 591
Cdd:COG4886 239 --------------QLTDL-------------------------------------------PELGNLTNLEEL------ 255

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 592 dflripyffraiDFSGNRFfgnipesvgllkelrllnlsgnsftSNIPqSLANLTNLETLDLSRNQLSGHIPRDLGSLSF 671
Cdd:COG4886 256 ------------DLSNNQL-------------------------TDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLG 297

                       410
                ....*....|....*..
gi 15229973 672 LSTMNFSHNLLEGPVPL 688
Cdd:COG4886 298 LNSLLLLLLLLNLLELL 314
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 134-342 2.42e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 2.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 134 LSRLTHLDLSSNQLTgeVLASVSKLNQLRDLLLSENSFSgNIPtSFTNLTKLSSLDISSNQFT-LENFSfilpNLTSLSS 212
Cdd:cd21340   1 LKRITHLYLNDKNIT--KIDNLSLCKNLKVLYLYDNKIT-KIE-NLEFLTNLTHLYLQNNQIEkIENLE----NLVNLKK 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 213 LNVASNHFkstlpSDMSGLHNLkyfdvrensfvgtfptslftiPSLQIVYLEgNQfmgpikfgNISSSSRLwdlnladnK 292
Cdd:cd21340  73 LYLGGNRI-----SVVEGLENL---------------------TNLEELHIE-NQ--------RLPPGEKL--------T 109

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 15229973 293 FDGPIPEYISEihSLIVLDLSHNNLVgpIPTSISKLVNLQHLSLSNNTLE 342
Cdd:cd21340 110 FDPRSLAALSN--SLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQIS 155
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
630-689 3.42e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 3.42e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15229973 630 SGNSFTSnIPQSLANLTNLETLDLSRNQLSgHIPRDLGSLSFLSTMNFSHNLLEG-PVPLG 689
Cdd:COG4886 121 SGNQLTD-LPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLTDlPEELG 179
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-277 3.63e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 3.63e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973  89 SLDLSyvllNNSLKPTSGLFKLQQLQNLTLSDCHLygEVTSSLGNLSRLTHLDLSSNQLTGEVLASVSKLNQLRDLLLSE 168
Cdd:COG4886 232 TLDLS----NNQLTDLPELGNLTNLEELDLSNNQL--TDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 169 NSFSGNIPTSFTNLTKLSSLDISSNQFTLENFSFILPNLTSLSSLNVASNHFKSTLPSDMSGLHNLKYFDVRENSFVGTF 248
Cdd:COG4886 306 LLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALL 385

                       170       180
                ....*....|....*....|....*....
gi 15229973 249 PTSLFTIPSLQIVYLEGNQFMGPIKFGNI 277
Cdd:COG4886 386 LLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 134-545 4.89e-05

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 47.18  E-value: 4.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973   134 LSRLTHLDLSSNQLTGEVlASVSKLNQLRDLLLSENSFSGNIPTSFTNLTKLSSLDISSNQfTLENfsfiLP---NLTSL 210
Cdd:PLN03210  633 LTGLRNIDLRGSKNLKEI-PDLSMATNLETLKLSDCSSLVELPSSIQYLNKLEDLDMSRCE-NLEI----LPtgiNLKSL 706

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973   211 SSLNvasnhfkstlpsdMSGLHNLKYF-DVREN-SFVGTFPTSLFTIPS---LQIVYLEGNQFMgpikfgnisSSSRLWD 285
Cdd:PLN03210  707 YRLN-------------LSGCSRLKSFpDISTNiSWLDLDETAIEEFPSnlrLENLDELILCEM---------KSEKLWE 764

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973   286 lnlaDNKFDGPIPEYISeiHSLIVLDLSHNNLVGPIPTSISKLVNLQHLSLSNNT-LEGEVPGC-LWGLMTVTLSHNS-F 362
Cdd:PLN03210  765 ----RVQPLTPLMTMLS--PSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENCInLETLPTGInLESLESLDLSGCSrL 838

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973   363 NSFGKSSSG----ALDGESMQELdlgsnslggpfPHWICKQRFLKYLDLS--NNLFngsippCLKNSTYWLKGLVLRNNS 436
Cdd:PLN03210  839 RTFPDISTNisdlNLSRTGIEEV-----------PWWIEKFSNLSFLDMNgcNNLQ------RVSLNISKLKHLETVDFS 901

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973   437 FSGFLPDVFVNAS---MLLSLDVSYNRLEGKLPKSLINCTGMELL-----NVGSNIIK---DTFPSW---------LVSL 496
Cdd:PLN03210  902 DCGALTEASWNGSpseVAMATDNIHSKLPSTVCINFINCFNLDQEallqqQSIFKQLIlsgEEVPSYfthrttgasLTNI 981

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 15229973   497 PSLRV------LILRSNAFYGSLYYDHISFGFQ---HLRLIDISQNGFSGTLSPLYFS 545
Cdd:PLN03210  982 PLLHIspcqpfFRFRACAVVDSESFFIISVSFDiqvCCRFIDRLGNHFDSPYQPHVFS 1039
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 107-317 2.30e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 2.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 107 LFKLQQLQNLTLSDCHLYGEVTSSLGNLSR----LTHLDLSSNQlTGEVLASV-------SKLNQLRDLLLSENSFSGNI 175
Cdd:cd00116  19 LPKLLCLQVLRLEGNTLGEEAAKALASALRpqpsLKELCLSLNE-TGRIPRGLqsllqglTKGCGLQELDLSDNALGPDG 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 176 PTSFTNLTK--------------------------------LSSLDISSNQFT---LENFSFILPNLTSLSSLNVASNHF 220
Cdd:cd00116  98 CGVLESLLRssslqelklnnnglgdrglrllakglkdlppaLEKLVLGRNRLEgasCEALAKALRANRDLKELNLANNGI 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 221 KS----TLPSDMSGLHNLKYFDVRENSF----VGTFPTSLFTIPSLQIVYLEGNQF----MGPIKFGNISSSSRLWDLNL 288
Cdd:cd00116 178 GDagirALAEGLKANCNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNNLtdagAAALASALLSPNISLLTLSL 257

                       250       260       270
                ....*....|....*....|....*....|...
gi 15229973 289 ADNKF--DGPIP--EYISEIHSLIVLDLSHNNL 317
Cdd:cd00116 258 SCNDItdDGAKDlaEVLAEKESLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
135-195 4.68e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 4.68e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15229973   135 SRLTHLDLSSNQLTGEVLASVSKLNQLRDLLLSENSFSGNIPTSFTNLTKLSSLDISSNQF 195
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
286-339 6.55e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 6.55e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 15229973   286 LNLADNKFDGPIPEYISEIHSLIVLDLSHNNLVGPIPTSISKLVNLQHLSLSNN 339
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 105-268 6.61e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 6.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 105 SGLFKLQQLQNLTLSDCHLYGEV---------TSSLGNLS-----------------------RLTHLDLSSNQLTG--- 149
Cdd:cd00116  75 QGLTKGCGLQELDLSDNALGPDGcgvlesllrSSSLQELKlnnnglgdrglrllakglkdlppALEKLVLGRNRLEGasc 154

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 150 EVLASVSKLNQ-LRDLLLSENSFSGN-IPT---SFTNLTKLSSLDISSNQFTLENFSFI---LPNLTSLSSLNVASN--- 218
Cdd:cd00116 155 EALAKALRANRdLKELNLANNGIGDAgIRAlaeGLKANCNLEVLDLNNNGLTDEGASALaetLASLKSLEVLNLGDNnlt 234

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 15229973 219 -----HFKSTLPSDMSGLHNLK-YFDVRENSFVGTFPTSLFTIPSLQIVYLEGNQF 268
Cdd:cd00116 235 dagaaALASALLSPNISLLTLSlSCNDITDDGAKDLAEVLAEKESLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
306-352 1.20e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.20e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 15229973   306 SLIVLDLSHNNLVGPIPTSISKLVNLQHLSLSNNTLEGEVPGCLWGL 352
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGL 48
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 630-680 3.58e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 3.58e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 15229973 630 SGNSFTSniPQSLANLTNLETLDLSRNQLSGH--IPRDLGSLSFLSTMNFSHN 680
Cdd:cd21340 128 SGNNIDS--LEPLAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDLTGN 178
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 107-218 4.09e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.54  E-value: 4.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973 107 LFKLQQLQNLTLSDCHLYGEVTSSLGNL----SRLTHLDLSSNQLTGEVLASVSKL----NQLRDLLLSENSFSG----N 174
Cdd:COG5238 232 LKGNKSLTTLDLSNNQIGDEGVIALAEAlknnTTVETLYLSGNQIGAEGAIALAKAlqgnTTLTSLDLSVNRIGDegaiA 311

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 15229973 175 IPTSFTNLTKLSSLDISSNQFTLENFSFILPNL---TSLSSLNVASN 218
Cdd:COG5238 312 LAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALqenTTLHSLDLSDN 358
LRR_8 pfam13855
Leucine rich repeat;
160-220 4.46e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 4.46e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15229973   160 QLRDLLLSENSFSGNIPTSFTNLTKLSSLDISSNQFT-LENFSFIlpNLTSLSSLNVASNHF 220
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTtLSPGAFS--GLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
208-268 7.75e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 7.75e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15229973   208 TSLSSLNVASNHFKSTLPSDMSGLHNLKYFDVRENSFVGTFPTSLFTIPSLQIVYLEGNQF 268
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
453-509 9.53e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 9.53e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15229973   453 SLDVSYNRLEGKLPKSLINCTGMELLNVGSNIIKDTFPSWLVSLPSLRVLILRSNAF 509
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 113-338 9.56e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.47  E-value: 9.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973   113 LQNLTLSDCHLYGEVTSSLGNLSRLTHLDLS-----SNQLTGEVLASVSKLN---------------QLRDLLLSENSFS 172
Cdd:PLN03210  659 LETLKLSDCSSLVELPSSIQYLNKLEDLDMSrcenlEILPTGINLKSLYRLNlsgcsrlksfpdistNISWLDLDETAIE 738

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973   173 gNIPTS--FTNLTKLSSLDISSNQFtLENFSFILPNLT----SLSSLNVASNHFKSTLPSDMSGLHNLKYFDVRENSFVG 246
Cdd:PLN03210  739 -EFPSNlrLENLDELILCEMKSEKL-WERVQPLTPLMTmlspSLTRLFLSDIPSLVELPSSIQNLHKLEHLEIENCINLE 816

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229973   247 TFPTSLfTIPSLQIVYLEGNQFMGpiKFGNISSSsrLWDLNLADNKFDgPIPEYISEIHSLIVLDLSHNNLVGPIPTSIS 326
Cdd:PLN03210  817 TLPTGI-NLESLESLDLSGCSRLR--TFPDISTN--ISDLNLSRTGIE-EVPWWIEKFSNLSFLDMNGCNNLQRVSLNIS 890

                         250
                  ....*....|..
gi 15229973   327 KLVNLQHLSLSN 338
Cdd:PLN03210  891 KLKHLETVDFSD 902
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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