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Conserved domains on  [gi|15229326|ref|NP_187117|]
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F-box and associated interaction domains-containing protein [Arabidopsis thaliana]

Protein Classification

F-box protein( domain architecture ID 12004213)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 118-356 7.68e-46

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


:

Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 157.14  E-value: 7.68e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229326   118 PIGGLIFGQNNTKAMIGNPSTGQFVPLPRIKT---QRKHIFSIFGYDPVNDLYKVLCMTVRTlrgphyfrwedpmwEEPM 194
Cdd:TIGR01640   3 PCDGLICFSYGKRLVVWNPSTGQSRWLPTPKSrrsNKESDTYFLGYDPIEKQYKVLCFSDRS--------------GNRN 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229326   195 TEEHQVFTLGPKqKWRMLECKYLHrHHSGSQGICRDGVMYYLASFNDKRS---LMSFDLSSEEFNV-TKLPEDY-ILQQF 269
Cdd:TIGR01640  69 QSEHQVYTLGSN-SWRTIECSPPH-HPLKSRGVCINGVLYYLAYTLKTNPdyfIVSFDVSSERFKEfIPLPCGNsDSVDY 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229326   270 GNMVDHSGKIAIVSQAYSGP-MDLWVLEDVSKEEWSKVAAI-VPSITDIVGNDQRVifrGILSTGEIILSllPTPKPPFF 347
Cdd:TIGR01640 147 LSLINYKGKLAVLKQKKDTNnFDLWVLNDAGKQEWSKLFTVpIPPLPDLVDDNFLS---GFTDKGEIVLC--CEDENPFY 221


                  ....*....
gi 15229326   348 FLCYDPKEK 356
Cdd:TIGR01640 222 IFYYNVGEN 230
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 22-60 2.06e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 425796  Cd Length: 43  Bit Score: 38.67  E-value: 2.06e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15229326    22 SILPLELKIEILMKSPPKSIAKLGFVSNHWSSIIRGQVF 60
Cdd:pfam00646   2 LDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKL 40
 
Name Accession Description Interval E-value
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 118-356 7.68e-46

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 157.14  E-value: 7.68e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229326   118 PIGGLIFGQNNTKAMIGNPSTGQFVPLPRIKT---QRKHIFSIFGYDPVNDLYKVLCMTVRTlrgphyfrwedpmwEEPM 194
Cdd:TIGR01640   3 PCDGLICFSYGKRLVVWNPSTGQSRWLPTPKSrrsNKESDTYFLGYDPIEKQYKVLCFSDRS--------------GNRN 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229326   195 TEEHQVFTLGPKqKWRMLECKYLHrHHSGSQGICRDGVMYYLASFNDKRS---LMSFDLSSEEFNV-TKLPEDY-ILQQF 269
Cdd:TIGR01640  69 QSEHQVYTLGSN-SWRTIECSPPH-HPLKSRGVCINGVLYYLAYTLKTNPdyfIVSFDVSSERFKEfIPLPCGNsDSVDY 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229326   270 GNMVDHSGKIAIVSQAYSGP-MDLWVLEDVSKEEWSKVAAI-VPSITDIVGNDQRVifrGILSTGEIILSllPTPKPPFF 347
Cdd:TIGR01640 147 LSLINYKGKLAVLKQKKDTNnFDLWVLNDAGKQEWSKLFTVpIPPLPDLVDDNFLS---GFTDKGEIVLC--CEDENPFY 221


                  ....*....
gi 15229326   348 FLCYDPKEK 356
Cdd:TIGR01640 222 IFYYNVGEN 230
FBA_3 pfam08268
F-box associated domain;
226-348 7.27e-42

F-box associated domain;


Pssm-ID: 285468  Cd Length: 125  Bit Score: 143.20  E-value: 7.27e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229326   226 GICRDGVMYYLASF--NDKRSLMSFDLSSEEFNVTKLPEDYILQQFGNMVDHSGKIAIVSQAYSGPMDLWVLEDVSKEEW 303
Cdd:pfam08268   1 GICINGVLYYGAWTsdNSKSVIVSFDVRSEKFDFIKLPVPLANDLSSTLINYKGKLAVVSHTSDGGIELWVLEDAEKHEW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 15229326   304 SKVAAIVPSITDIVGNDQRVIFRGILSTGEIILSLLPTPKPPFFF 348
Cdd:pfam08268  81 SKKIFVLPPSHEHLVDNTDLSVVGTTRTGEIILVLPSTLSKPFYV 125
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 22-60 2.06e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 38.67  E-value: 2.06e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15229326    22 SILPLELKIEILMKSPPKSIAKLGFVSNHWSSIIRGQVF 60
Cdd:pfam00646   2 LDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKL 40
FBOX smart00256
A Receptor for Ubiquitination Targets;
24-60 4.09e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 37.42  E-value: 4.09e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 15229326     24 LPLELKIEILMKSPPKSIAKLGFVSNHWSSIIRGQVF 60
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDF 37
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 22-60 3.43e-03

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 35.13  E-value: 3.43e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15229326  22 SILPLELKIEILMKSPPKSIAKLGFVSNHWSSIIRGQVF 60
Cdd:cd22157   1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
 
Name Accession Description Interval E-value
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 118-356 7.68e-46

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 157.14  E-value: 7.68e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229326   118 PIGGLIFGQNNTKAMIGNPSTGQFVPLPRIKT---QRKHIFSIFGYDPVNDLYKVLCMTVRTlrgphyfrwedpmwEEPM 194
Cdd:TIGR01640   3 PCDGLICFSYGKRLVVWNPSTGQSRWLPTPKSrrsNKESDTYFLGYDPIEKQYKVLCFSDRS--------------GNRN 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229326   195 TEEHQVFTLGPKqKWRMLECKYLHrHHSGSQGICRDGVMYYLASFNDKRS---LMSFDLSSEEFNV-TKLPEDY-ILQQF 269
Cdd:TIGR01640  69 QSEHQVYTLGSN-SWRTIECSPPH-HPLKSRGVCINGVLYYLAYTLKTNPdyfIVSFDVSSERFKEfIPLPCGNsDSVDY 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229326   270 GNMVDHSGKIAIVSQAYSGP-MDLWVLEDVSKEEWSKVAAI-VPSITDIVGNDQRVifrGILSTGEIILSllPTPKPPFF 347
Cdd:TIGR01640 147 LSLINYKGKLAVLKQKKDTNnFDLWVLNDAGKQEWSKLFTVpIPPLPDLVDDNFLS---GFTDKGEIVLC--CEDENPFY 221


                  ....*....
gi 15229326   348 FLCYDPKEK 356
Cdd:TIGR01640 222 IFYYNVGEN 230
FBA_3 pfam08268
F-box associated domain;
226-348 7.27e-42

F-box associated domain;


Pssm-ID: 285468  Cd Length: 125  Bit Score: 143.20  E-value: 7.27e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15229326   226 GICRDGVMYYLASF--NDKRSLMSFDLSSEEFNVTKLPEDYILQQFGNMVDHSGKIAIVSQAYSGPMDLWVLEDVSKEEW 303
Cdd:pfam08268   1 GICINGVLYYGAWTsdNSKSVIVSFDVRSEKFDFIKLPVPLANDLSSTLINYKGKLAVVSHTSDGGIELWVLEDAEKHEW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 15229326   304 SKVAAIVPSITDIVGNDQRVIFRGILSTGEIILSLLPTPKPPFFF 348
Cdd:pfam08268  81 SKKIFVLPPSHEHLVDNTDLSVVGTTRTGEIILVLPSTLSKPFYV 125
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 22-60 2.06e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 38.67  E-value: 2.06e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15229326    22 SILPLELKIEILMKSPPKSIAKLGFVSNHWSSIIRGQVF 60
Cdd:pfam00646   2 LDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKL 40
FBOX smart00256
A Receptor for Ubiquitination Targets;
24-60 4.09e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 37.42  E-value: 4.09e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 15229326     24 LPLELKIEILMKSPPKSIAKLGFVSNHWSSIIRGQVF 60
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDF 37
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 22-60 3.43e-03

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 35.13  E-value: 3.43e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 15229326  22 SILPLELKIEILMKSPPKSIAKLGFVSNHWSSIIRGQVF 60
Cdd:cd22157   1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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