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Conserved domains on  [gi|42563469|ref|NP_187025|]
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SET domain protein 20 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET super family cl40432
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 141-307 6.31e-42

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


The actual alignment was detected with superfamily member cd10538:

Pssm-ID: 394802 [Multi-domain]  Cd Length: 217  Bit Score: 145.21  E-value: 6.31e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 141 DESGCEC-ERCEEGYCKCLAFAGME---------------EIANECGSGCGCGSDCSNRVTQKGVSVSLKIVRDEKKGW- 203
Cdd:cd10538  23 DSVGCKCkDDCLDSKCACAAESDGIfaytkngllrlnnspPPIFECNSKCSCDDDCKNRVVQRGLQARLQVFRTSKKGWg 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 204 -------------CLYADQLI--KQARRRQNIYDKLRStqsfaSALLVVREHLPSGQACLRINIDATRIGNVARFINHSC 268
Cdd:cd10538 103 vrslefipkgsfvCEYVGEVIttSEADRRGKIYDKSGG-----SYLFDLDEFSDSDGDGEELCVDATFCGNVSRFINHSC 177

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 42563469 269 DgGNLSTVLLRSSGALL--PRLCFFAAKDIIAEEELSFSYG 307
Cdd:cd10538 178 D-PNLFPFNVVIDHDDLryPRIALFATRDILPGEELTFDYG 217
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 70-183 1.05e-05

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


:

Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 43.56  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469    70 ARSLENISIPFHNSIDSQR-YAYFIYTPfqipasspppprqwwgaaanecgsesRPCFDSvsesgrfGVSLVDESGCECE 148
Cdd:pfam05033   2 SKGKENVPIPVVNEVDDEPpPPDFTYIT--------------------------SYIYPK-------EFLLIIPQGCDCG 48

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 42563469   149 RCEEGYCKCLAFAGMEEIAN----------------ECGSGCGCGSDCSNR 183
Cdd:pfam05033  49 DCSSEKCSCAQLNGGEFRFPydkdgllvpeskppiyECNPLCGCPPSCPNR 99
 
Name Accession Description Interval E-value
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 141-307 6.31e-42

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 145.21  E-value: 6.31e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 141 DESGCEC-ERCEEGYCKCLAFAGME---------------EIANECGSGCGCGSDCSNRVTQKGVSVSLKIVRDEKKGW- 203
Cdd:cd10538  23 DSVGCKCkDDCLDSKCACAAESDGIfaytkngllrlnnspPPIFECNSKCSCDDDCKNRVVQRGLQARLQVFRTSKKGWg 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 204 -------------CLYADQLI--KQARRRQNIYDKLRStqsfaSALLVVREHLPSGQACLRINIDATRIGNVARFINHSC 268
Cdd:cd10538 103 vrslefipkgsfvCEYVGEVIttSEADRRGKIYDKSGG-----SYLFDLDEFSDSDGDGEELCVDATFCGNVSRFINHSC 177

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 42563469 269 DgGNLSTVLLRSSGALL--PRLCFFAAKDIIAEEELSFSYG 307
Cdd:cd10538 178 D-PNLFPFNVVIDHDDLryPRIALFATRDILPGEELTFDYG 217
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 191-310 1.25e-15

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 72.37  E-value: 1.25e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469    191 VSLKIVRDEKKGWCLYADQLI----------------KQARRRQNIYDKLRSTQSFASallvvrehlpsgQACLRINIDA 254
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIpkgefigeyvgeiitsEEAEERPKAYDTDGAKAFYLF------------DIDSDLCIDA 68

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 42563469    255 TRIGNVARFINHSCDgGNLSTVLLRSSGAllPRLCFFAAKDIIAEEELSFSYGDVS 310
Cdd:smart00317  69 RRKGNLARFINHSCE-PNCELLFVEVNGD--DRIVIFALRDIKPGEELTIDYGSDY 121
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 202-307 1.09e-13

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 66.78  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469   202 GWCLYADQLIK-----------------QARRRQNIYDKLRSTQSFASALLVVREhlpsgQACLRINIDATRIGNVARFI 264
Cdd:pfam00856   1 GRGLFATEDIPkgefigeyvevllitkeEADKRELLYYDKLELRLWGPYLFTLDE-----DSEYCIDARALYYGNWARFI 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 42563469   265 NHSCDgGNLSTVLLRSSGalLPRLCFFAAKDIIAEEELSFSYG 307
Cdd:pfam00856  76 NHSCD-PNCEVRVVYVNG--GPRIVIFALRDIKPGEELTIDYG 115
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
252-332 1.76e-10

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 58.05  E-value: 1.76e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 252 IDATRIGNVARFINHSCDgGNLSTVLLRssgallPRLCFFAAKDIIAEEELSFSYGdvsvaGENRDDKLNCSCGSscCLG 331
Cdd:COG2940  68 IDGALGGNPARFINHSCD-PNCEADEED------GRIFIVALRDIAAGEELTYDYG-----LDYDEEEYPCRCPN--CRG 133


                .
gi 42563469 332 T 332
Cdd:COG2940 134 T 134
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 70-183 1.05e-05

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 43.56  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469    70 ARSLENISIPFHNSIDSQR-YAYFIYTPfqipasspppprqwwgaaanecgsesRPCFDSvsesgrfGVSLVDESGCECE 148
Cdd:pfam05033   2 SKGKENVPIPVVNEVDDEPpPPDFTYIT--------------------------SYIYPK-------EFLLIIPQGCDCG 48

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 42563469   149 RCEEGYCKCLAFAGMEEIAN----------------ECGSGCGCGSDCSNR 183
Cdd:pfam05033  49 DCSSEKCSCAQLNGGEFRFPydkdgllvpeskppiyECNPLCGCPPSCPNR 99
 
Name Accession Description Interval E-value
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 141-307 6.31e-42

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 145.21  E-value: 6.31e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 141 DESGCEC-ERCEEGYCKCLAFAGME---------------EIANECGSGCGCGSDCSNRVTQKGVSVSLKIVRDEKKGW- 203
Cdd:cd10538  23 DSVGCKCkDDCLDSKCACAAESDGIfaytkngllrlnnspPPIFECNSKCSCDDDCKNRVVQRGLQARLQVFRTSKKGWg 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 204 -------------CLYADQLI--KQARRRQNIYDKLRStqsfaSALLVVREHLPSGQACLRINIDATRIGNVARFINHSC 268
Cdd:cd10538 103 vrslefipkgsfvCEYVGEVIttSEADRRGKIYDKSGG-----SYLFDLDEFSDSDGDGEELCVDATFCGNVSRFINHSC 177

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 42563469 269 DgGNLSTVLLRSSGALL--PRLCFFAAKDIIAEEELSFSYG 307
Cdd:cd10538 178 D-PNLFPFNVVIDHDDLryPRIALFATRDILPGEELTFDYG 217
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 143-338 9.28e-42

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 145.90  E-value: 9.28e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 143 SGCECE--RCEEGYCKCLAFAGME---------EIAN------ECGSGCGCGSDCSNRVTQKGVSVSLKIVRDEKKGW-- 203
Cdd:cd10544  25 PGCDCKtsSCEPETCSCLRKYGPNydddgclldFDGKysgpvfECNSMCKCSESCQNRVVQNGLQFKLQVFKTPKKGWgl 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 204 ------------CLYADQLI--KQARRRQniydkLRSTQSFASALLVVREHLPSGQaCLRINIDATRIGNVARFINHSCD 269
Cdd:cd10544 105 rtlefipkgrfvCEYAGEVIgfEEARRRT-----KSQTKGDMNYIIVLREHLSSGK-VLETFVDPTYIGNIGRFLNHSCE 178

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42563469 270 gGNLSTVLLRSSGaLLPRLCFFAAKDIIAEEELSFSYG----------DVSVAGENRDDKLnCSCGSSCCLGTLPCENT 338
Cdd:cd10544 179 -PNLFMVPVRVDS-MVPKLALFAARDIVAGEELSFDYSgefsnsvesvTLARQDESKSRKP-CLCGAENCRGFLPFDES 254
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 143-333 2.25e-29

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 112.77  E-value: 2.25e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 143 SGCEC-ERCEEGYCKCLAFAGMEEIAN---------------ECGSGCGCGSDCSNRVTQKGVSVSLKIVR-DEKKGWCL 205
Cdd:cd10542  23 VGCECtEDCHNNNPTCCPAESGVKFAYdkqgrlrlppgtpiyECNSRCKCGPDCPNRVVQRGRKVPLCIFRtSNGRGWGV 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 206 YADQLIKQ----------------ARRRQNIYDKLRSTQSFAsallvvrehLP--SGQACLriNIDATRIGNVARFINHS 267
Cdd:cd10542 103 KTLEDIKKgtfvmeyvgeiitseeAERRGKIYDANGRTYLFD---------LDynDDDCEY--TVDAAYYGNISHFINHS 171

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42563469 268 CDgGNLST--VLLRSSGALLPRLCFFAAKDIIAEEELSFSY-----GDVSVAGENR--DDKLNCSCGSSCCLGTL 333
Cdd:cd10542 172 CD-PNLAVyaVWINHLDPRLPRIAFFAKRDIKAGEELTFDYlmtgtGGSSESTIPKpkDVRVPCLCGSKNCRKYL 245
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 136-333 4.27e-23

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 96.11  E-value: 4.27e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 136 GVSLVDES--GCECERCEEGYCkCLAFAGMEEIAN--------------ECGSGCGCGSDCSNRVTQKGVSVSLKIVR-D 198
Cdd:cd10532  14 GINLDNEAtvGCDCSDCFFGKC-CPAEAGVLFAYNehgqlkippgtpiyECNSRCKCGPDCPNRVVQKGTQYSLCIFRtS 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 199 EKKGWCLYADQLIK----------------QARRRQNIYDKLRSTQSFasALLVVREHLpsgqaclriNIDATRIGNVAR 262
Cdd:cd10532  93 NGRGWGVKTLQKIKknsfvmeyvgevitseEAERRGQFYDSKGITYLF--DLDYESDEF---------TVDAARYGNVSH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 263 FINHSCDgGNLS--TVLLRSSGALLPRLCFFAAKDIIAEEELSFSY-----GDVS-----VAGENRDDKLNCSCGSSCCL 330
Cdd:cd10532 162 FVNHSCD-PNLQvfNVFIDNLDTRLPRIALFSTRTIKAGEELTFDYqmkgsGDLSsdsidNSPAKKRVRTVCKCGAVTCR 240


                ...
gi 42563469 331 GTL 333
Cdd:cd10532 241 GYL 243
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 143-307 5.92e-23

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 95.16  E-value: 5.92e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 143 SGCECE-RCEEGY--CKCLAFAGMEEIAN-------------ECGSGCGCGSDCSNRVTQKGVSVSLKIVRDEKKGW--- 203
Cdd:cd10545  22 TGCDCKnRCTDGAsdCACVKKNGGEIPYNfngrlirakpaiyECGPLCKCPPSCYNRVTQKGLRYRLEVFKTAERGWgvr 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 204 -----------CLYADQLIK--QARRR----------QNIYD-KLRSTQSFASALLVVR-----EHLPSGQAClrinIDA 254
Cdd:cd10545 102 swdsipagsfiCEYVGELLDtsEADTRsgnddylfdiDNRQTnRGWDGGQRLDVGMSDGerssaEDEESSEFT----IDA 177

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 42563469 255 TRIGNVARFINHSCDgGNL--STVLLRSSGALLPRLCFFAAKDIIAEEELSFSYG 307
Cdd:cd10545 178 GSFGNVARFINHSCS-PNLfvQCVLYDHNDLRLPRVMLFAADNIPPLQELTYDYG 231
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 169-329 1.48e-22

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 94.33  E-value: 1.48e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 169 ECGSGCGCGSDCSNRVTQKGVSVSLKIVRDEKKGW--------------CLYADQLIK--QARRRQNiydklrstqsfAS 232
Cdd:cd10543  69 ECNRACSCWRNCRNRVVQNGIRYRLQLFRTRGMGWgvralqdipkgtfvCEYIGELISdsEADSRED-----------DS 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 233 ALLVVREHLPSGqAClrinIDATRIGNVARFINHSCDGgNLSTVL-------LRssgalLPRLCFFAAKDIIAEEELSFS 305
Cdd:cd10543 138 YLFDLDNKDGET-YC----IDARRYGNISRFINHLCEP-NLIPVRvfvehqdLR-----FPRIAFFASRDIKAGEELGFD 206

                       170       180
                ....*....|....*....|....
gi 42563469 306 YGDVSVAGENRddKLNCSCGSSCC 329
Cdd:cd10543 207 YGEKFWRIKGK--YFTCRCGSPKC 228
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 143-333 3.11e-21

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 91.09  E-value: 3.11e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 143 SGCECER---CE---EGYCKCL------AFAGMEE---------IANECGSGCGCGSDCSNRVTQKGVSVSLKIVRDEKK 201
Cdd:cd20073  24 SGCSCSKlggCDlnnPGSCQCLedsnekSFAYDEYgrvrantgsIIYECNENCDCGINCPNRVVQRGRKLPLEIFKTKHK 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 202 GWCLYADQLIK----------------QARRRQNIYDKLRSTQSFASALLvvrehlpSGQACLRINIDATRIGNVARFIN 265
Cdd:cd20073 104 GWGLRCPRFIKagtfigvylgevitqsEAEIRGKKYDNVGVTYLFDLDLF-------EDQVDEYYTVDAQYCGDVTRFIN 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 266 HSCDgGNLS--TVLLRSSGALLPRLCFFAAKDIIAEEELSFSY------------GDVSVAG-ENRDDKLNCSCGSSCCL 330
Cdd:cd20073 177 HSCD-PNLAiySVLRDKSDSKIYDLAFFAIKDIPALEELTFDYsgrnnfdqlgfiGNRSNSKyINLKNKRPCYCGSANCR 255


                ...
gi 42563469 331 GTL 333
Cdd:cd20073 256 GWL 258
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 74-333 2.46e-20

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 89.27  E-value: 2.46e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469  74 ENISIPFHNSIDSQRYAYFIYTPFQIPASspppprqwwGAAANeCGSE---SRPCFDSVSesgrfgvslvDESGCECERC 150
Cdd:cd10517  14 EGVPIPCVNEIDNSSPPYVEYSKERIPGK---------GVNIN-LDPDflvGCDCTDGCR----------DKSKCACQQL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 151 EEGYCKCLAFAGMEEIAN---------------ECGSGCGCGSDCSNRVTQKGVSVSLKIVRDEKKGW------------ 203
Cdd:cd10517  74 TIEATAATPGGQINPSAGyqyrrlmeklptgvyECNSRCKCDKRCYNRVVQNGLQVRLQVFKTEKKGWgirclddipkgs 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 204 --CLYADQLI---KQARRRQNIYDklrstQSFASA-LLVVREHLPSG------QACLriNIDATRIGNVARFINHSCDgG 271
Cdd:cd10517 154 fvCIYAGQILtedEANEEGLQYGD-----EYFAELdYIEVVEKLKEGyesdveEHCY--IIDAKSEGNLGRYLNHSCS-P 225

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42563469 272 NLST--VLLRSSGALLPRLCFFAAKDIIAEEELSFSYG-DV-SVAGenrdDKLNCSCGSSCCLGTL 333
Cdd:cd10517 226 NLFVqnVFVDTHDLRFPWVAFFASRYIRAGTELTWDYNyEVgSVPG----KVLYCYCGSSNCRGRL 287
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 136-333 2.41e-18

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 83.52  E-value: 2.41e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 136 GVSLVDE---SGCEC---ERCEEGYCKCL----------------------AFAGM--EEIAN------ECGSGCGCGSD 179
Cdd:cd19473  14 GVELADEefrSGCECtddEDCMYSGCLCLqdvdpdddrdpgkkknayhssgAKKGClrGHMLNsrlpiyECHEGCACSDD 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 180 CSNRVTQKGVSVSLKIVR-DEKKGWCLYADQLIK------------------QARR-------RQNIY----DKLRSTQS 229
Cdd:cd19473  94 CPNRVVERGRKVPLQIFRtSDGRGWGVRSTVDIKrgqfvdcyvgeiitpeeaQRRRdaatiaqRKDVYlfalDKFSDPDS 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 230 FASALLvvrehlpsgQACLRIniDATRIGNVARFINHSCDGgNLS--TVLLRSSGALLPRLCFFAAKDIIAEEELSFSY- 306
Cdd:cd19473 174 LDPRLR---------GDPYEI--DGEFMSGPTRFINHSCDP-NLRifARVGDHADKHIHDLAFFAIKDIPRGTELTFDYv 241

                       250       260       270
                ....*....|....*....|....*....|...
gi 42563469 307 ----GDVSVAGENRDDKL--NCSCGSSCCLGTL 333
Cdd:cd19473 242 dgvtGLDDDAGDEEKEKEmtKCLCGSPKCRGYL 274
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 144-329 3.38e-18

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 82.63  E-value: 3.38e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 144 GCECERC----EEGYCKCLA---FAGMEE---------IANECGSGCGCGSDCSNRVTQKGVSVSLKIVR-DEKKGWCL- 205
Cdd:cd10525  23 GCECQDClsqpVGGCCPGASkhrFAYNEQgqvkvrpglPIYECNSRCRCGPDCPNRVVQKGIQYDLCIFRtDNGRGWGVr 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 206 -------------YADQLI--KQARRRQNIYDKLRSTQSFasALLVVREhlpsgqaclRINIDATRIGNVARFINHSCDG 270
Cdd:cd10525 103 tlekirknsfvmeYVGEIItsEEAERRGQIYDRQGATYLF--DLDYVED---------VYTVDAAYYGNISHFVNHSCDP 171

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42563469 271 G-NLSTVLLRSSGALLPRLCFFAAKDIIAEEELSFSYG---------------DVSVAG----ENRDDKLNCSCGSSCC 329
Cdd:cd10525 172 NlQVYNVFIDNLDERLPRIALFATRTIRAGEELTFDYNmqvdpvdaestkmdsNFGLAGlpgsPKKRVRIECKCGVRSC 250
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 169-329 1.02e-17

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 81.22  E-value: 1.02e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 169 ECGSGCGCGSDCSNRVTQKGVSVSLKIVRDEKKGW--------------CLYADQLIKQARRrqniydKLRSTQSFASAL 234
Cdd:cd10533  69 ECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWgvralqtipqgtfiCEYVGELISDAEA------DVREDDSYLFDL 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 235 lvvrEHLPSGQAClrinIDATRIGNVARFINHSCDGGNLST-VLLRSSGALLPRLCFFAAKDIIAEEELSFSYGDvsVAG 313
Cdd:cd10533 143 ----DNKDGEVYC----IDARYYGNISRFINHLCDPNIIPVrVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGD--RFW 212

                       170
                ....*....|....*.
gi 42563469 314 ENRDDKLNCSCGSSCC 329
Cdd:cd10533 213 DIKSKYFTCQCGSEKC 228
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 169-329 1.09e-16

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 78.05  E-value: 1.09e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 169 ECGSGCGCGSDCSNRVTQKGVSVSLKIVRDEKKGW--------------CLYADQLIKQARRrqniydKLRSTQSFASAL 234
Cdd:cd10535  69 ECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWgvrslqdippgtfvCEYVGELISDSEA------DVREEDSYLFDL 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 235 lvvrEHLPSGQAClrinIDATRIGNVARFINHSCDGGNLSTVLLRSSGAL-LPRLCFFAAKDIIAEEELSFSYGDvsVAG 313
Cdd:cd10535 143 ----DNKDGEVYC----IDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLrFPRIAFFSTRLIEAGEQLGFDYGE--RFW 212

                       170
                ....*....|....*.
gi 42563469 314 ENRDDKLNCSCGSSCC 329
Cdd:cd10535 213 DIKGKLFSCRCGSPKC 228
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 193-333 1.54e-16

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 75.31  E-value: 1.54e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 193 LKIVRDEKKGWCLYADQLI----------------KQARRRQNIYDKLRSTQSFASALlvvrehlpSGQAClrinIDATR 256
Cdd:cd19172   4 VEVFRTEKKGWGLRAAEDLpkgtfvieyvgevldeKEFKRRMKEYAREGNRHYYFMAL--------KSDEI----IDATK 71

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42563469 257 IGNVARFINHSCDgGNLSTVLLRSSGALlpRLCFFAAKDIIAEEELSFSYgDVSVAGenrDDKLNCSCGSSCCLGTL 333
Cdd:cd19172  72 KGNLSRFINHSCE-PNCETQKWTVNGEL--RVGFFAKRDIPAGEELTFDY-QFERYG---KEAQKCYCGSPNCRGYI 141
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 193-329 2.94e-16

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 74.21  E-value: 2.94e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 193 LKIVRDEKKGWCLYADQLIKQ----------------ARRRQNIYDKLRSTQSFasallvvrehlpsgqaCLRIN----I 252
Cdd:cd10531   2 LELFRTEKKGWGVKAKEDIQKgefiieyvgevidkkeFKERLDEYEELGKSNFY----------------ILSLSddvvI 65

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42563469 253 DATRIGNVARFINHSCDgGNLSTVLLRSSGAllPRLCFFAAKDIIAEEELSFSYGDVSVAGENRDdklnCSCGSSCC 329
Cdd:cd10531  66 DATRKGNLSRFINHSCE-PNCETQKWIVNGE--YRIGIFALRDIPAGEELTFDYNFVNYNEAKQV----CLCGAQNC 135
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 191-310 1.25e-15

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 72.37  E-value: 1.25e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469    191 VSLKIVRDEKKGWCLYADQLI----------------KQARRRQNIYDKLRSTQSFASallvvrehlpsgQACLRINIDA 254
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIpkgefigeyvgeiitsEEAEERPKAYDTDGAKAFYLF------------DIDSDLCIDA 68

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 42563469    255 TRIGNVARFINHSCDgGNLSTVLLRSSGAllPRLCFFAAKDIIAEEELSFSYGDVS 310
Cdd:smart00317  69 RRKGNLARFINHSCE-PNCELLFVEVNGD--DRIVIFALRDIKPGEELTIDYGSDY 121
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 169-333 1.77e-15

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 75.25  E-value: 1.77e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 169 ECGSGCGCGSD-CSNRVTQKGVSVSLKIVRDEKKGW--------------CLYADQLIKQARRRQNiYDKLRSTQSFASA 233
Cdd:cd10523  85 ECNVSCKCNRMlCQNRVVQHGLQVRLQVFKTEKKGWgvrclddidkgtfvCIYAGRVLSRARSPTE-PLPPKLELPSENE 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 234 LLVVREHL-PSGQACLRIN---IDATRIGNVARFINHSCDgGNL--STVLLRSSGALLPRLCFFAAKDIIAEEELSFSYG 307
Cdd:cd10523 164 VEVVTSWLiLSKKRKLRENvcfLDASKEGNVGRFLNHSCC-PNLfvQNVFVDTHDKNFPWVAFFTNRVVKAGTELTWDYS 242

                       170       180
                ....*....|....*....|....*.
gi 42563469 308 dvSVAGENRDDKLNCSCGSSCCLGTL 333
Cdd:cd10523 243 --YDAGTSPEQEIPCLCGVNKCQKKI 266
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 202-307 1.09e-13

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 66.78  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469   202 GWCLYADQLIK-----------------QARRRQNIYDKLRSTQSFASALLVVREhlpsgQACLRINIDATRIGNVARFI 264
Cdd:pfam00856   1 GRGLFATEDIPkgefigeyvevllitkeEADKRELLYYDKLELRLWGPYLFTLDE-----DSEYCIDARALYYGNWARFI 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 42563469   265 NHSCDgGNLSTVLLRSSGalLPRLCFFAAKDIIAEEELSFSYG 307
Cdd:pfam00856  76 NHSCD-PNCEVRVVYVNG--GPRIVIFALRDIKPGEELTIDYG 115
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 206-308 8.04e-13

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 64.19  E-value: 8.04e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 206 YADQLIKQ--ARRRQNIYDKLRSTQSFASallvvrehlpSGQAClrinIDATRIGNVARFINHSCDGGNLSTVLLRSSGA 283
Cdd:cd10519  30 YTGELISQdeADRRGKIYDKYNSSYLFNL----------NDQFV----VDATRKGNKIRFANHSSNPNCYAKVMMVNGDH 95

                        90       100
                ....*....|....*....|....*
gi 42563469 284 llpRLCFFAAKDIIAEEELSFSYGD 308
Cdd:cd10519  96 ---RIGIFAKRDIEAGEELFFDYGY 117
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 247-331 8.64e-13

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 65.01  E-value: 8.64e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 247 CLRIN----IDATRIGNVARFINHSCDgGNLSTVLLRSSGalLPRLCFFAAKDIIAEEELSFSYGDVSVageNRDDKLNC 322
Cdd:cd19174  55 CLNLDsgmvIDGYRMGNEARFVNHSCD-PNCEMQKWSVNG--VYRIGLFALKDIPAGEELTYDYNFHSF---NVEKQQPC 128


                ....*....
gi 42563469 323 SCGSSCCLG 331
Cdd:cd19174 129 KCGSPNCRG 137
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 169-333 1.00e-12

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 66.80  E-value: 1.00e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 169 ECGSGCGCGSD-CSNRVTQKGVSVSLKIVRDEKKGW--------------CLYADQLIKQARRRQniyDKLRSTQSFASA 233
Cdd:cd10541  69 ECNKLCKCDPNmCQNRLVQHGLQVRLQLFKTQNKGWgirclddiakgtfvCIYAGKILTDDFADK---EGLEMGDEYFAN 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 234 LLVVREhlpsgqACLRIniDATRIGNVARFINHSCdGGNL--STVLLRSSGALLPRLCFFAAKDIIAEEELSFSYGdvSV 311
Cdd:cd10541 146 LDHIEE------SCYII--DAKLEGNLGRYLNHSC-SPNLfvQNVFVDTHDLRFPWVAFFASKRIKAGTELTWDYN--YE 214

                       170       180
                ....*....|....*....|..
gi 42563469 312 AGENRDDKLNCSCGSSCCLGTL 333
Cdd:cd10541 215 VGSVEGKELLCCCGSNECRGRL 236
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 186-308 1.49e-12

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 64.13  E-value: 1.49e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 186 QKGVSVSLKIVRDEKKGWCLYADQL----------------IKQARRRQNIYDKLRSTQSFasalLVVREHlPSGQAClr 249
Cdd:cd10528  12 LSGKEEGLKVIEIDGKGRGVIATRPfekgdfvveyhgdlitITEAKKREALYAKDPSTGCY----MYYFQY-KGKTYC-- 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 250 inIDATRI-GNVARFINHSCDGGNLSTVLLRSSGalLPRLCFFAAKDIIAEEELSFSYGD 308
Cdd:cd10528  85 --VDATKEsGRLGRLINHSKKKPNLKTKLLVIDG--VPHLILVAKRDIKPGEELLYDYGD 140
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 249-333 2.48e-11

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 60.79  E-value: 2.48e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 249 RInIDATRIGNVARFINHSCDgGNLSTVLLRSSGAllPRLCFFAAKDIIAEEELSFSYGDVSVAgenrDDKLNCSCGSSC 328
Cdd:cd19173  65 RI-IDAGPKGNLSRFMNHSCQ-PNCETQKWTVNGD--TRVGLFAVRDIPAGEELTFNYNLDCLG----NEKKVCRCGAPN 136


                ....*
gi 42563469 329 CLGTL 333
Cdd:cd19173 137 CSGFL 141
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 249-329 3.72e-11

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 60.30  E-value: 3.72e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 249 RIN----IDATRIGNVARFINHSCDGGNLSTVLlrsSGALLPRLCFFAAKDIIAEEELSFSYGDVSVAGEnrddKLNCSC 324
Cdd:cd10518  72 RIDedlvIDATKKGNIARFINHSCDPNCYAKII---TVDGEKHIVIFAKRDIAPGEELTYDYKFPIEDEE----KIPCLC 144


                ....*
gi 42563469 325 GSSCC 329
Cdd:cd10518 145 GAPNC 149
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
252-332 1.76e-10

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 58.05  E-value: 1.76e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 252 IDATRIGNVARFINHSCDgGNLSTVLLRssgallPRLCFFAAKDIIAEEELSFSYGdvsvaGENRDDKLNCSCGSscCLG 331
Cdd:COG2940  68 IDGALGGNPARFINHSCD-PNCEADEED------GRIFIVALRDIAAGEELTYDYG-----LDYDEEEYPCRCPN--CRG 133


                .
gi 42563469 332 T 332
Cdd:COG2940 134 T 134
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 252-333 2.40e-10

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 57.81  E-value: 2.40e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 252 IDATRIGNVARFINHSCDGgnlSTVLLRSSGALLPRLCFFAAKDIIAEEELSFSYGDVSVaGENRDdklnCSCGSSCCLG 331
Cdd:cd19175  65 IDATFKGNLSRFINHSCDP---NCELQKWQVDGETRIGVFAIRDIKKGEELTYDYQFVQF-GADQD----CHCGSKNCRG 136


                ..
gi 42563469 332 TL 333
Cdd:cd19175 137 KL 138
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 252-329 5.14e-10

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 57.05  E-value: 5.14e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42563469 252 IDATRIGNVARFINHSCDgGNLSTVLLRSSGAllPRLCFFAAKDIIAEEELSFSYgdvsvAGENRDDKLNCSCGSSCC 329
Cdd:cd20072  78 VDATKKGNIARFINHCCD-PNCTAKIIKVEGE--KRIVIYAKRDIAAGEELTYDY-----KFPREEDKIPCLCGAPNC 147
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 194-333 1.21e-09

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 56.15  E-value: 1.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 194 KIVRDEKKGWCLYADQLIKQARRRQNIYDKLRSTQSFASALLVVREHLPSGQACLRIN----IDATRIGNVARFINHSCD 269
Cdd:cd19211   5 KIIKTEGKGWGLIAKRDIKKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDkdriIDAGPKGNYSRFMNHSCQ 84

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42563469 270 gGNLSTVLLRSSGAllPRLCFFAAKDIIAEEELSFSYgDVSVAGenrDDKLNCSCGSSCCLGTL 333
Cdd:cd19211  85 -PNCETQKWTVNGD--TRVGLFAVCDIPAGTELTFNY-NLDCLG---NEKTVCRCGAPNCSGFL 141
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 252-308 1.75e-09

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 55.04  E-value: 1.75e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 42563469 252 IDATRIGNVARFINHScDGGNLSTVLLRSSGalLPRLCFFAAKDIIAEEELSFSYGD 308
Cdd:cd10522  65 IDAGKKGNLTRFINHS-DQPNLELIVRTLKG--EQHIGFVAIRDIKPGEELFISYGP 118
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 252-329 3.83e-09

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 54.65  E-value: 3.83e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42563469 252 IDATRIGNVARFINHSCDGGNLSTVLlrsSGALLPRLCFFAAKDIIAEEELSFSYgdvsvAGENRDDKLNCSCGSSCC 329
Cdd:cd19169  78 IDATKCGNLARFINHSCNPNCYAKII---TVESQKKIVIYSKRPIAVNEEITYDY-----KFPIEDEKIPCLCGAPQC 147
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 252-333 5.63e-09

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 54.32  E-value: 5.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 252 IDATRIGNVARFINHSCDGGNLSTVLLRSSgalLPRLCFFAAKDIIAEEELSFSYgdvSVAGEnrDDKLNCSCGSSCCLG 331
Cdd:cd19170  78 VDATMHGNAARFINHSCEPNCYSRVVNIDG---KKHIVIFALRRILRGEELTYDY---KFPIE--DVKIPCTCGSKKCRK 149


                ..
gi 42563469 332 TL 333
Cdd:cd19170 150 YL 151
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 235-307 1.53e-08

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 50.71  E-value: 1.53e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42563469 235 LVVREHLPSGqaclrinidaTRIGnVARFINHSCDGgNLSTVLLRSSGalLPRLCFFAAKDIIAEEELSFSYG 307
Cdd:cd08161  14 LFATRDIPKG----------EVIG-LARFINHSCEP-NCEFEEVYVGG--KPRVFIVALRDIKAGEELTVDYG 72
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 250-308 2.37e-08

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 51.81  E-value: 2.37e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42563469 250 INIDATRIGNVARFINHS---CDGGNLSTVLLRSSGALlpRLCFFAAKDIIAEEELSFSYGD 308
Cdd:cd19168  63 IWVDAAIYGNLSRYINHAtdkVKTGNCMPKIMYVNHEW--RIKFTAIKDIKIGEELFFNYGD 122
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 249-329 1.17e-07

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 50.51  E-value: 1.17e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 249 RIN----IDATRIGNVARFINHSCDGGNLSTVLLRSSGallPRLCFFAAKDIIAEEELSFSYG-DVsvagENRDDKLNCS 323
Cdd:cd19171  71 RIDndwvIDATMTGGPARYINHSCNPNCVAEVVTFDKE---KKIIIISNRRIAKGEELTYDYKfDF----EDDQHKIPCL 143


                ....*.
gi 42563469 324 CGSSCC 329
Cdd:cd19171 144 CGAPNC 149
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 252-333 1.91e-07

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 50.05  E-value: 1.91e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 252 IDATRIGNVARFINHSCDGGNLSTVLLRSSGAllpRLCFFAAKDIIAEEELSFSYgdvsvAGENRDDKLNCSCGSSCCLG 331
Cdd:cd19205  79 IDATKCGNFARFINHSCNPNCYAKVITVESQK---KIVIYSKQHINVNEEITYDY-----KFPIEDVKIPCLCGSENCRG 150


                ..
gi 42563469 332 TL 333
Cdd:cd19205 151 TL 152
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 252-333 2.01e-07

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 50.02  E-value: 2.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 252 IDATRIGNVARFINHSCDGGNLSTVLLRSSGAllpRLCFFAAKDIIAEEELSFSYgdvsvAGENRDDKLNCSCGSSCCLG 331
Cdd:cd19204  79 IDATKCGNLARFINHCCTPNCYAKVITIESQK---KIVIYSKQPIGVNEEITYDY-----KFPIEDNKIPCLCGTENCRG 150


                ..
gi 42563469 332 TL 333
Cdd:cd19204 151 TL 152
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 252-329 2.71e-07

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 49.64  E-value: 2.71e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42563469 252 IDATRIGNVARFINHSCDGGNLSTVlLRSSGAllPRLCFFAAKDIIAEEELSFSYgdvSVAGENRDDKLNCSCGSSCC 329
Cdd:cd19206  78 VDATMHGNAARFINHSCEPNCYSRV-INIDGQ--KHIVIFAMRKIYRGEELTYDY---KFPIEDASNKLPCNCGAKKC 149
AWS smart00570
associated with SET domains; subdomain of PRESET
 141-190 9.83e-07

associated with SET domains; subdomain of PRESET


Pssm-ID: 197795  Cd Length: 50  Bit Score: 45.08  E-value: 9.83e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 42563469    141 DESGCECERCE--EGYCK--CLAFAgmeeIANECGSGCGCGSDCSNRVTQKGVS 190
Cdd:smart00570   1 DIMTCECKPTDddETACGsdCLNRM----LFIECSSSCPCGSYCSNQRFQKRQY 50
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 252-329 2.08e-06

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 46.94  E-value: 2.08e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42563469 252 IDATRIGNVARFINHSCDGGNLSTVLLRSSGAllpRLCFFAAKDIIAEEELSFSYgdvSVAGENRDDKLNCSCGSSCC 329
Cdd:cd19207  78 VDATMHGNAARFINHSCEPNCYSRVIHVEGQK---HIVIFALRKIYRGEELTYDY---KFPIEDASNKLPCNCGAKRC 149
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 193-333 6.91e-06

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 45.30  E-value: 6.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 193 LKIVRDEKKGWCLYADQLIKQARRRQNIYDKLRSTQSFASALLVVREHLPSGQACLRIN----IDATRIGNVARFINHSC 268
Cdd:cd19210   4 VEIFRTLGRGWGLRCKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDkdriIDAGPKGNYARFMNHCC 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 42563469 269 DgGNLSTVLLRSSGAllPRLCFFAAKDIIAEEELSFSYgDVSVAGenrDDKLNCSCGSSCCLGTL 333
Cdd:cd19210  84 Q-PNCETQKWTVNGD--TRVGLFALCDIKAGTELTFNY-NLECLG---NGKTVCKCGAPNCSGFL 141
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 194-333 8.15e-06

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 44.92  E-value: 8.15e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 194 KIVRDEKKGWCL--------------YADQLIKQARRRQNIYDKLRSTQSFASALLVVREHLpsgqaclrinIDATRIGN 259
Cdd:cd19212   5 EIIKTERRGWGLrtkrsikkgefvneYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRI----------IDAGPKGN 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42563469 260 VARFINHSCDgGNLSTVLLRSSGALlpRLCFFAAKDIIAEEELSFSYgDVSVAGENRDDklnCSCGSSCCLGTL 333
Cdd:cd19212  75 YSRFMNHSCN-PNCETQKWTVNGDV--RVGLFALCDIPAGMELTFNY-NLDCLGNGRTE---CHCGADNCSGFL 141
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 70-183 1.05e-05

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 43.56  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469    70 ARSLENISIPFHNSIDSQR-YAYFIYTPfqipasspppprqwwgaaanecgsesRPCFDSvsesgrfGVSLVDESGCECE 148
Cdd:pfam05033   2 SKGKENVPIPVVNEVDDEPpPPDFTYIT--------------------------SYIYPK-------EFLLIIPQGCDCG 48

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 42563469   149 RCEEGYCKCLAFAGMEEIAN----------------ECGSGCGCGSDCSNR 183
Cdd:pfam05033  49 DCSSEKCSCAQLNGGEFRFPydkdgllvpeskppiyECNPLCGCPPSCPNR 99
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 206-306 2.13e-04

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 40.82  E-value: 2.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 206 YADQLIKQ--ARRRQNIYDKLRSTQSFASALLVVrehlpsgqaclrinIDATRIGNVARFINHSCDGGNLSTVLLRSSGA 283
Cdd:cd19217  35 YCGELISQdeADRRGKVYDKYMSSFLFNLNNDFV--------------VDATRKGNKIRFANHSVNPNCYAKVVMVNGDH 100

                        90       100
                ....*....|....*....|...
gi 42563469 284 llpRLCFFAAKDIIAEEELSFSY 306
Cdd:cd19217 101 ---RIGIFAKRAIQQGEELFFDY 120
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 206-306 2.87e-04

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 39.90  E-value: 2.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563469 206 YADQLIKQ--ARRRQNIYDKLRSTQSFASALLVVrehlpsgqaclrinIDATRIGNVARFINHSCDGGNLSTVLLRSSGA 283
Cdd:cd19218  33 YCGEIISQdeADRRGKVYDKYMCSFLFNLNNDFV--------------VDATRKGNKIRFANHSVNPNCYAKVMMVNGDH 98

                        90       100
                ....*....|....*....|...
gi 42563469 284 llpRLCFFAAKDIIAEEELSFSY 306
Cdd:cd19218  99 ---RIGIFAKRAIQTGEELFFDY 118
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 250-307 1.54e-03

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 38.92  E-value: 1.54e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 42563469 250 INIDATRIGNVARFINHSCDgGNLSTVLLRSSGALLPRLCFFAAKDIIAEEELSFSYG 307
Cdd:cd19183  67 LYIDTRRSGSVARFIRRSCR-PNAELVTVASDSGSVLKFVLYASRDISPGEEITIGWD 123
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 252-306 3.14e-03

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 37.25  E-value: 3.14e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 42563469 252 IDATRIGNVARFINHSCDgGNLSTVLLRSSGALLpRLCFFAAKDIIAEEE--LSFSY 306
Cdd:cd10529  71 VDARKYGNEARFIRRSCR-PNAELRHVVVSNGEL-RLFIFALKDIRKGTEitIPFDY 125
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 263-329 3.30e-03

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 36.97  E-value: 3.30e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 42563469 263 FINHSCDggnlSTVLLRSSGAllPRLCFFAAKDIIAEEELSFSYGDVSVAGENRDDKLNCSCGSSCC 329
Cdd:cd20071  58 LLNHSCD----PNAVVVFDGN--GTLRVRALRDIKAGEELTISYIDPLLPRTERRRELLEKYGFTCS 118
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 261-328 6.20e-03

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 36.49  E-value: 6.20e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42563469 261 ARFINHSCDggnlSTVLLRSSGAllPRLCFFAAKDIIAEEELSFSYGDVSVAGENRDdklnCSCgSSC 328
Cdd:cd10524  77 AAFINHDCR----PNCKFVPTGK--STACVKVLRDIEPGEEITVYYGDNYFGENNEE----CEC-ETC 133
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 252-329 6.22e-03

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 36.91  E-value: 6.22e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42563469 252 IDATRIGNVARFINHSCDGGNLSTVLLRSSGAllpRLCFFAAKDIIAEEELSFSYgdvSVAGENRDDKLNCSCGSSCC 329
Cdd:cd19208  79 IDATLTGGPARYINHSCAPNCVAEVVTFEKGH---KIIISSSRRIQKGEELCYDY---KFDFEDDQHKIPCHCGAVNC 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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