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Conserved domains on  [gi|15228516|ref|NP_186979|]
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Adenine nucleotide alpha hydrolases-like superfamily protein [Arabidopsis thaliana]

Protein Classification

universal stress protein( domain architecture ID 10084616)

universal stress protein (USP) enhances the rate of cell survival during prolonged exposure to stress agents

CATH:  3.40.50.620
Gene Ontology:  GO:0005524|GO:0050896
PubMed:  23745136|12012333|36902153
SCOP:  4003850

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 107-250 5.72e-15

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


:

Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 70.07  E-value: 5.72e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228516 107 RVMVVVDKVIASTGALEWALKHTLQSQDYLFLLYFSKPFRKG------KRKNRKSEVKTDELVHTLKKLCQtkRPGIEVE 180
Cdd:cd00293   1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSslsgglEELADELKEEAEELLEEAKKLAE--EAGVEVE 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228516 181 IRRLQGkekEKGEKIVEEAKEQQVSLLVVGKEKKPPVWRLLkrWGwkkrrgraGTLKYCLEKASCMTIAV 250
Cdd:cd00293  79 TIVVEG---DPAEAILEEAKELGADLIVMGSRGRSGLKRLL--LG--------SVSEYVLRHAPCPVLVV 135
 
Name Accession Description Interval E-value
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 107-250 5.72e-15

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 70.07  E-value: 5.72e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228516 107 RVMVVVDKVIASTGALEWALKHTLQSQDYLFLLYFSKPFRKG------KRKNRKSEVKTDELVHTLKKLCQtkRPGIEVE 180
Cdd:cd00293   1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSslsgglEELADELKEEAEELLEEAKKLAE--EAGVEVE 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228516 181 IRRLQGkekEKGEKIVEEAKEQQVSLLVVGKEKKPPVWRLLkrWGwkkrrgraGTLKYCLEKASCMTIAV 250
Cdd:cd00293  79 TIVVEG---DPAEAILEEAKELGADLIVMGSRGRSGLKRLL--LG--------SVSEYVLRHAPCPVLVV 135
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 108-251 8.73e-12

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 61.27  E-value: 8.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228516   108 VMVVVDKVIASTGALEWALKHTLQSQDYLFLLYFSKPFRKGKRKNRKSEVKTDELVHTLKKLCQTKR------PGIEVEI 181
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAaaaaeaGGVKVEV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15228516   182 RRLQGkekEKGEKIVEEAKEQQVSLLVVgkekkppvwrllkrwGWKKRRGRAG-----TLKYCLEKASCMTIAVK 251
Cdd:pfam00582  81 VVVVG---DPAEEILEVAEEEDADLIVM---------------GSRGRSGLSRlllgsVAEYVLRHAPCPVLVVR 137
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
106-221 2.02e-05

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 43.37  E-value: 2.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228516 106 NRVMVVVDKVIASTGALEWALKHTLQSQDYLFLLY-FSKPFRKGKRKNRKSEVKTDELVHTLKKLCQT-KRPGIEVEIRR 183
Cdd:COG0589   3 KRILVPTDGSEEAERALEYAAELAKALGAELHLLHvVDPPPSAAAGPEELEEELREEAEEALEEAAERlEEAGVEVETVV 82

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15228516 184 LQGkekEKGEKIVEEAKEQQVSLLVVGKEKKPPVWRLL 221
Cdd:COG0589  83 REG---DPAEAILEAAEELDADLIVMGSRGRSGLRRLL 117
 
Name Accession Description Interval E-value
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 107-250 5.72e-15

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 70.07  E-value: 5.72e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228516 107 RVMVVVDKVIASTGALEWALKHTLQSQDYLFLLYFSKPFRKG------KRKNRKSEVKTDELVHTLKKLCQtkRPGIEVE 180
Cdd:cd00293   1 KILVAVDGSEESERALEWALELAKRPGAELTLLHVVDPPPSSslsgglEELADELKEEAEELLEEAKKLAE--EAGVEVE 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228516 181 IRRLQGkekEKGEKIVEEAKEQQVSLLVVGKEKKPPVWRLLkrWGwkkrrgraGTLKYCLEKASCMTIAV 250
Cdd:cd00293  79 TIVVEG---DPAEAILEEAKELGADLIVMGSRGRSGLKRLL--LG--------SVSEYVLRHAPCPVLVV 135
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 107-245 3.68e-14

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 68.03  E-value: 3.68e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228516 107 RVMVVVDKVIASTGALEWALKHTLQSQDYLFLLY-----------FSKPFRKGKRKNRKSEVKTDELVHTLKKLCQTKRp 175
Cdd:cd23659   2 KVLIAVDGSEESEYALEWALENLHRPGDEVVLLHvieppslpaasLGSGSEEWEALEEEAREKAEKLLEKYEKKLKEEK- 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15228516 176 GIEVEIRRLQGKekeKGEKIVEEAKEQQVSLLVVGKekkppvwrllkrwgwkkrRGRaGTLK---------YCLEKASC 245
Cdd:cd23659  81 GIKVKVEVVAGD---PGEVICKAAEELKADLIVMGS------------------RGL-GALKrtllgsvsdYVVHHSPC 137
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 108-251 8.73e-12

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 61.27  E-value: 8.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228516   108 VMVVVDKVIASTGALEWALKHTLQSQDYLFLLYFSKPFRKGKRKNRKSEVKTDELVHTLKKLCQTKR------PGIEVEI 181
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAaaaaeaGGVKVEV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15228516   182 RRLQGkekEKGEKIVEEAKEQQVSLLVVgkekkppvwrllkrwGWKKRRGRAG-----TLKYCLEKASCMTIAVK 251
Cdd:pfam00582  81 VVVVG---DPAEEILEVAEEEDADLIVM---------------GSRGRSGLSRlllgsVAEYVLRHAPCPVLVVR 137
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
106-221 2.02e-05

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 43.37  E-value: 2.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15228516 106 NRVMVVVDKVIASTGALEWALKHTLQSQDYLFLLY-FSKPFRKGKRKNRKSEVKTDELVHTLKKLCQT-KRPGIEVEIRR 183
Cdd:COG0589   3 KRILVPTDGSEEAERALEYAAELAKALGAELHLLHvVDPPPSAAAGPEELEEELREEAEEALEEAAERlEEAGVEVETVV 82

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 15228516 184 LQGkekEKGEKIVEEAKEQQVSLLVVGKEKKPPVWRLL 221
Cdd:COG0589  83 REG---DPAEAILEAAEELDADLIVMGSRGRSGLRRLL 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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