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Conserved domains on  [gi|15227330|ref|NP_181668|]
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Ankyrin repeat family protein / BTB/POZ domain-containing protein [Arabidopsis thaliana]

Protein Classification

BTB/POZ domain and ankyrin repeat-containing protein( domain architecture ID 13033746)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) and ANK (ankyrin repeat) domain-containing protein similar to Arabidopsis thaliana regulatory protein NPR5 (also known as BOP2), which is involved in the regulation of leaf and floral patterning in Arabidopsis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 9-169 2.82e-53

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 176.34  E-value: 2.82e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330   9 RSLSLDFLNLLINGQ-AFSDVTFSVE-GRLVHAHRCILAARSLFFRKFFCGTDSPQPVTGIDPTqhgsvpasptrgstaP 86
Cdd:cd18310   1 KKLSSDLENLLDSPDlFYSDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLE---------------L 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  87 AGIIPVNSVGYEVFLLLLQFLYSGQVSIVPQkhePRPNCGERGCWHTHCSAAVDLALDTLAASRYFGVEQLALLTQKQLA 166
Cdd:cd18310  66 RELIPGGIVGYDAFMLVLSYLYSGRLRLVPK---EGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQRRLL 142


                ...
gi 15227330 167 SMV 169
Cdd:cd18310 143 DFV 145
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
262-360 2.36e-16

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.61  E-value: 2.36e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330 262 ALDSSDVELVKLMVmGEGLNLDE-----SLALHYAVESCSREVVKALLELGAaDVNYPaGPAGKTPLHIAAEMVSPDMVA 336
Cdd:COG0666 127 AAYNGNLEIVKLLL-EAGADVNAqdndgNTPLHLAAANGNLEIVKLLLEAGA-DVNAR-DNDGETPLHLAAENGHLEIVK 203

                        90       100
                ....*....|....*....|....
gi 15227330 337 VLLDHHADPNVRTVGGITPLDILR 360
Cdd:COG0666 204 LLLEAGADVNAKDNDGKTALDLAA 227
DUF3420 super family cl13357
Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. ...
 204-260 1.08e-07

Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with pfam00023.


The actual alignment was detected with superfamily member pfam11900:

Pssm-ID: 314729  Cd Length: 47  Bit Score: 48.18  E-value: 1.08e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15227330   204 GLPPEILAKHLPIDVVTKIEELRLKSSIArrSLMPHNhhhdlsvaQDLEDQKIRRMR 260
Cdd:pfam11900   1 DLDNFCLEKELPPEVLAKIKELRLKSSLP--SLSPEL--------DDLLEKRVRRIL 47
 
Name Accession Description Interval E-value
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 9-169 2.82e-53

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 176.34  E-value: 2.82e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330   9 RSLSLDFLNLLINGQ-AFSDVTFSVE-GRLVHAHRCILAARSLFFRKFFCGTDSPQPVTGIDPTqhgsvpasptrgstaP 86
Cdd:cd18310   1 KKLSSDLENLLDSPDlFYSDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLE---------------L 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  87 AGIIPVNSVGYEVFLLLLQFLYSGQVSIVPQkhePRPNCGERGCWHTHCSAAVDLALDTLAASRYFGVEQLALLTQKQLA 166
Cdd:cd18310  66 RELIPGGIVGYDAFMLVLSYLYSGRLRLVPK---EGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQRRLL 142


                ...
gi 15227330 167 SMV 169
Cdd:cd18310 143 DFV 145
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
262-360 2.36e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.61  E-value: 2.36e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330 262 ALDSSDVELVKLMVmGEGLNLDE-----SLALHYAVESCSREVVKALLELGAaDVNYPaGPAGKTPLHIAAEMVSPDMVA 336
Cdd:COG0666 127 AAYNGNLEIVKLLL-EAGADVNAqdndgNTPLHLAAANGNLEIVKLLLEAGA-DVNAR-DNDGETPLHLAAENGHLEIVK 203

                        90       100
                ....*....|....*....|....
gi 15227330 337 VLLDHHADPNVRTVGGITPLDILR 360
Cdd:COG0666 204 LLLEAGADVNAKDNDGKTALDLAA 227
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 16-112 1.09e-13

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 66.90  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330    16 LNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGTDSPQPVTgidptqhgsvpasptrgstapagIIPVNSV 95
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVS-----------------------EITLDDV 57

                          90
                  ....*....|....*..
gi 15227330    96 GYEVFLLLLQFLYSGQV 112
Cdd:pfam00651  58 SPEDFEALLEFMYTGKL 74
Ank_2 pfam12796
Ankyrin repeats (3 copies);
267-348 1.06e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330   267 DVELVKLMVMGEG----LNLDESLALHYAVESCSREVVKALLELGAADVNYpagpAGKTPLHIAAEMVSPDMVAVLLDHH 342
Cdd:pfam12796   9 NLELVKLLLENGAdanlQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD----NGRTALHYAARSGHLEIVKLLLEKG 84


                  ....*.
gi 15227330   343 ADPNVR 348
Cdd:pfam12796  85 ADINVK 90
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 27-167 3.21e-11

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 59.63  E-value: 3.21e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330     27 DVTFSVEGRLVHAHRCILAARSLFFRKFFCGTDSPQPVTgidptqhgsvpasptrgstapagIIPVNSVGYEVFLLLLQF 106
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKS-----------------------EIYLDDVSPEDFRALLNF 57

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15227330    107 LYSGQVSIVPqkheprpncgergcwhthcsaavDLALDTLAASRYFGVEQLALLTQKQLAS 167
Cdd:smart00225  58 LYTGKLDLPE-----------------------ENVEELLELADYLQIPGLVELCEEFLLK 95
PHA03095 PHA03095
ankyrin-like protein; Provisional
 267-359 3.31e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 58.88  E-value: 3.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  267 DVELVKLMV-MGEGLNLDES---LALHYAVES-CSREVVKALLELGAaDVNYPAGpAGKTPLHI--AAEMVSPDMVAVLL 339
Cdd:PHA03095  62 VKDIVRLLLeAGADVNAPERcgfTPLHLYLYNaTTLDVIKLLIKAGA-DVNAKDK-VGRTPLHVylSGFNINPKVIRLLL 139

                         90       100
                 ....*....|....*....|
gi 15227330  340 DHHADPNVRTVGGITPLDIL 359
Cdd:PHA03095 140 RKGADVNALDLYGMTPLAVL 159
DUF3420 pfam11900
Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. ...
 204-260 1.08e-07

Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with pfam00023.


Pssm-ID: 314729  Cd Length: 47  Bit Score: 48.18  E-value: 1.08e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15227330   204 GLPPEILAKHLPIDVVTKIEELRLKSSIArrSLMPHNhhhdlsvaQDLEDQKIRRMR 260
Cdd:pfam11900   1 DLDNFCLEKELPPEVLAKIKELRLKSSLP--SLSPEL--------DDLLEKRVRRIL 47
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 319-347 9.36e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 9.36e-05
                           10        20
                   ....*....|....*....|....*....
gi 15227330    319 GKTPLHIAAEMVSPDMVAVLLDHHADPNV 347
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 256-344 2.93e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.00  E-value: 2.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330 256 IRRMRRALDSSDVELVKLMVMGEGlnldeslALHYAVESCSREVVKALLELGAADVNYPAGP---AGKTPLHIAAEMVSP 332
Cdd:cd22192  30 VQAIKKLLKCPSCDLFQRGALGET-------ALHVAALYDNLEAAVVLMEAAPELVNEPMTSdlyQGETALHIAVVNQNL 102

                        90
                ....*....|..
gi 15227330 333 DMVAVLLDHHAD 344
Cdd:cd22192 103 NLVRELIARGAD 114
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 287-346 6.35e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 39.29  E-value: 6.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227330   287 ALHYAVESCSREVVKALLELGaADVNYPAGPA-------------GKTPLHIAAEMVSPDMVAVLLDHHADPN 346
Cdd:TIGR00870 131 ALHLAAHRQNYEIVKLLLERG-ASVPARACGDffvksqgvdsfyhGESPLNAAACLGSPSIVALLSEDPADIL 202
 
Name Accession Description Interval E-value
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 9-169 2.82e-53

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 176.34  E-value: 2.82e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330   9 RSLSLDFLNLLINGQ-AFSDVTFSVE-GRLVHAHRCILAARSLFFRKFFCGTDSPQPVTGIDPTqhgsvpasptrgstaP 86
Cdd:cd18310   1 KKLSSDLENLLDSPDlFYSDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLE---------------L 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  87 AGIIPVNSVGYEVFLLLLQFLYSGQVSIVPQkhePRPNCGERGCWHTHCSAAVDLALDTLAASRYFGVEQLALLTQKQLA 166
Cdd:cd18310  66 RELIPGGIVGYDAFMLVLSYLYSGRLRLVPK---EGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQRRLL 142


                ...
gi 15227330 167 SMV 169
Cdd:cd18310 143 DFV 145
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
262-360 2.36e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.61  E-value: 2.36e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330 262 ALDSSDVELVKLMVmGEGLNLDE-----SLALHYAVESCSREVVKALLELGAaDVNYPaGPAGKTPLHIAAEMVSPDMVA 336
Cdd:COG0666 127 AAYNGNLEIVKLLL-EAGADVNAqdndgNTPLHLAAANGNLEIVKLLLEAGA-DVNAR-DNDGETPLHLAAENGHLEIVK 203

                        90       100
                ....*....|....*....|....
gi 15227330 337 VLLDHHADPNVRTVGGITPLDILR 360
Cdd:COG0666 204 LLLEAGADVNAKDNDGKTALDLAA 227
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
262-358 3.07e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.23  E-value: 3.07e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330 262 ALDSSDVELVKLMVmGEGLNLDE-----SLALHYAVESCSREVVKALLELGAaDVNYPaGPAGKTPLHIAAEMVSPDMVA 336
Cdd:COG0666  94 AARNGDLEIVKLLL-EAGADVNArdkdgETPLHLAAYNGNLEIVKLLLEAGA-DVNAQ-DNDGNTPLHLAAANGNLEIVK 170

                        90       100
                ....*....|....*....|..
gi 15227330 337 VLLDHHADPNVRTVGGITPLDI 358
Cdd:COG0666 171 LLLEAGADVNARDNDGETPLHL 192
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-114 1.76e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 71.43  E-value: 1.76e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  25 FSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGtdspqpvtgidptqhgsvpasptRGSTAPAGIIPVNSVGYEVFLLLL 104
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSS-----------------------GMKESSSSEIELDDVSPEAFEALL 57

                        90
                ....*....|
gi 15227330 105 QFLYSGQVSI 114
Cdd:cd18186  58 DYIYTGELEL 67
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-163 1.92e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 72.28  E-value: 1.92e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  19 LINGQAFSDVTFSV--EGRLVHAHRCILAARSLFFRKFFcgtdSPQPVTgidPTQHGSVPASPTRgstaPagiipvnsvg 96
Cdd:cd18294   8 LINNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMF----LTGPQK---ESTQSPLVLSDIE----P---------- 66

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15227330  97 yEVFLLLLQFLYSGQVSIVPqkheprpncgergcwhthcsaavDLALDTLAASRYFGVEQLALLTQK 163
Cdd:cd18294  67 -EVFRAVLEFIYTNCVTLSN-----------------------HTVIEVLAAAVEYGLDELRKLCER 109
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-169 6.41e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 70.77  E-value: 6.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  19 LINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGtdspqpvtgidptqhgsvpasptRGSTAPAGIIPVNSVGYE 98
Cdd:cd18297   6 YVNNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSS-----------------------GSTEAQTPVIEIPDIRYD 62

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15227330  99 VFLLLLQFLYSGQVSIVpqkheprpncgergcwhthcSAAVDLALDTLAASRYFGVEQLALLTQKQLASMV 169
Cdd:cd18297  63 IFQLMMQYLYTGGVESL--------------------DVAQDDALELLRAASFFQLDGLKRHCEILLSQQI 113
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
208-356 1.96e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 73.83  E-value: 1.96e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330 208 EILAKHLPIDVVTKIEELRLKSSIARRSLMPHNHHHDLSVAQDLEDQKIRRMRRALDSSDVELVKLMVMGEGLNLDE--- 284
Cdd:COG0666   6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAkdd 85

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15227330 285 --SLALHYAVESCSREVVKALLELGaADVNYPaGPAGKTPLHIAAEMVSPDMVAVLLDHHADPNVRTVGGITPL 356
Cdd:COG0666  86 ggNTLLHAAARNGDLEIVKLLLEAG-ADVNAR-DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 16-112 1.09e-13

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 66.90  E-value: 1.09e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330    16 LNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGTDSPQPVTgidptqhgsvpasptrgstapagIIPVNSV 95
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVS-----------------------EITLDDV 57

                          90
                  ....*....|....*..
gi 15227330    96 GYEVFLLLLQFLYSGQV 112
Cdd:pfam00651  58 SPEDFEALLEFMYTGKL 74
Ank_2 pfam12796
Ankyrin repeats (3 copies);
267-348 1.06e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.90  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330   267 DVELVKLMVMGEG----LNLDESLALHYAVESCSREVVKALLELGAADVNYpagpAGKTPLHIAAEMVSPDMVAVLLDHH 342
Cdd:pfam12796   9 NLELVKLLLENGAdanlQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD----NGRTALHYAARSGHLEIVKLLLEKG 84


                  ....*.
gi 15227330   343 ADPNVR 348
Cdd:pfam12796  85 ADINVK 90
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-113 2.17e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 60.71  E-value: 2.17e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330   8 LRSLSLDFLNLLINGQaFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGtdspqpvtGIDPTQHGSVpasPTRGSTAPA 87
Cdd:cd18287   6 VHFLSEDIGALFLNEE-YSDVTFVVEEKRFPAHRVILAARSEYFRALLYG--------GMRESQQSEI---ELKDTNAEA 73

                        90       100
                ....*....|....*....|....*.
gi 15227330  88 giipvnsvgyevFLLLLQFLYSGQVS 113
Cdd:cd18287  74 ------------FKALLKYIYTGRLT 87
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 27-167 3.21e-11

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 59.63  E-value: 3.21e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330     27 DVTFSVEGRLVHAHRCILAARSLFFRKFFCGTDSPQPVTgidptqhgsvpasptrgstapagIIPVNSVGYEVFLLLLQF 106
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKS-----------------------EIYLDDVSPEDFRALLNF 57

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15227330    107 LYSGQVSIVPqkheprpncgergcwhthcsaavDLALDTLAASRYFGVEQLALLTQKQLAS 167
Cdd:smart00225  58 LYTGKLDLPE-----------------------ENVEELLELADYLQIPGLVELCEEFLLK 95
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 18-116 1.70e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 58.02  E-value: 1.70e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  18 LLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGtdspqpvtgidptqhgsvpasPTRGSTapAGIIPVNSVGY 97
Cdd:cd18300   2 LFLNKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGG---------------------NFRESS--AKEVELPGVSK 58

                        90
                ....*....|....*....
gi 15227330  98 EVFLLLLQFLYSGQVSIVP 116
Cdd:cd18300  59 ETFLALLEYLYTDQAPILE 77
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
262-358 9.25e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.58  E-value: 9.25e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330 262 ALDSSDVELVKLMVmGEGLNLD-----ESLALHYAVESCSREVVKALLELGAaDVNYpAGPAGKTPLHIAAEMVSPDMVA 336
Cdd:COG0666 160 AAANGNLEIVKLLL-EAGADVNardndGETPLHLAAENGHLEIVKLLLEAGA-DVNA-KDNDGKTALDLAAENGNLEIVK 236

                        90       100
                ....*....|....*....|..
gi 15227330 337 VLLDHHADPNVRTVGGITPLDI 358
Cdd:COG0666 237 LLLEAGADLNAKDKDGLTALLL 258
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 25-114 1.19e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 54.86  E-value: 1.19e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  25 FSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGTDSPQPVtgidptqhgsvpasptrgstapagIIPVNSVGYEVFLLLL 104
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDEHP------------------------VIILPDVPYSELKALL 56

                        90
                ....*....|
gi 15227330 105 QFLYSGQVSI 114
Cdd:cd18315  57 DFIYTGEVNV 66
PHA03095 PHA03095
ankyrin-like protein; Provisional
 267-359 3.31e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 58.88  E-value: 3.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  267 DVELVKLMV-MGEGLNLDES---LALHYAVES-CSREVVKALLELGAaDVNYPAGpAGKTPLHI--AAEMVSPDMVAVLL 339
Cdd:PHA03095  62 VKDIVRLLLeAGADVNAPERcgfTPLHLYLYNaTTLDVIKLLIKAGA-DVNAKDK-VGRTPLHVylSGFNINPKVIRLLL 139

                         90       100
                 ....*....|....*....|
gi 15227330  340 DHHADPNVRTVGGITPLDIL 359
Cdd:PHA03095 140 RKGADVNALDLYGMTPLAVL 159
Ank_5 pfam13857
Ankyrin repeats (many copies);
303-358 6.28e-09

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 51.96  E-value: 6.28e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15227330   303 LLELGAADVNYPAGpAGKTPLHIAAEMVSPDMVAVLLDHHADPNVRTVGGITPLDI 358
Cdd:pfam13857   1 LLEHGPIDLNRLDG-EGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 8-114 7.78e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 53.80  E-value: 7.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330   8 LRSLSLDFLNLLINGQAfSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGTDspqpvtgidptqhgsvpasptRGSTapA 87
Cdd:cd18286   1 CSRLGKDLLQLFLNGED-SDITIKVDGKTFKAHRCILCARSSYFAAMLSGSW---------------------AESN--S 56

                        90       100
                ....*....|....*....|....*..
gi 15227330  88 GIIPVNSVGYEVFLLLLQFLYSGQVSI 114
Cdd:cd18286  57 SEITLTGVSHAAVSFVLLFIYGGVLDL 83
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 20-116 1.12e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 53.25  E-value: 1.12e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  20 INGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGTDSPQPVTGIDptqhgsvpasptrgstapagiIPvnSVGYEV 99
Cdd:cd18352   8 VNNATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIE---------------------IP--NIRWEV 64

                        90
                ....*....|....*..
gi 15227330 100 FLLLLQFLYSGQVSIVP 116
Cdd:cd18352  65 FELMMRFIYTGSVDITN 81
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 14-55 1.33e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 53.02  E-value: 1.33e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 15227330  14 DFLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFF 55
Cdd:cd18295   8 EFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMF 49
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-165 1.34e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 53.10  E-value: 1.34e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  14 DFLNLLINGQAfSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGtdspqpvtgidPTQHGSVpasptrgstapaGIIPVN 93
Cdd:cd18280   4 HFGALLESEEG-ADVTFNVDGEKFRAHKLVLAARSPVFRSMLFG-----------PMREENE------------GEIVIE 59

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15227330  94 SVGYEVFLLLLQFLYSGQvsiVPQKHEPRPNCGErgcwhthcSAAVDLALDTLAASRYFGVEQLALLTQKQL 165
Cdd:cd18280  60 DVEPPVFKALLHFIYKDE---LPDDVEPAGSDSS--------SLDTTMAQHLLAAADRYALERLRLLCESRL 120
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 22-122 1.89e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 51.90  E-value: 1.89e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  22 GQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGTDSPQPVTGIDPTQHgsvpasptrgstapagiipVNSVGYEVFL 101
Cdd:cd18301  15 GDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAVGCDVVH-------------------IEKVPPEIFE 75

                        90       100
                ....*....|....*....|.
gi 15227330 102 LLLQFLYSGQVSIVPQKHEPR 122
Cdd:cd18301  76 QLLQFIYTDTCDLLTDGYKPK 96
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-121 2.31e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 52.46  E-value: 2.31e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  16 LNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGTdspqpvtgidptqhgsvpaspTRGSTAPAgiIPVNSV 95
Cdd:cd18250  12 LSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGE---------------------LRESRADR--VVLHGV 68

                        90       100
                ....*....|....*....|....*.
gi 15227330  96 GYEVFLLLLQFLYSGQVSIVPQKHEP 121
Cdd:cd18250  69 SAEILGLLLDFSYTGRVTVTQDNVEA 94
Ank_2 pfam12796
Ankyrin repeats (3 copies);
288-358 6.52e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.11  E-value: 6.52e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15227330   288 LHYAVESCSREVVKALLELGaADVNYPAgPAGKTPLHIAAEMVSPDMVAVLLDhHADPNVRTVGGiTPLDI 358
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQD-KNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNGR-TALHY 67
DUF3420 pfam11900
Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. ...
 204-260 1.08e-07

Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with pfam00023.


Pssm-ID: 314729  Cd Length: 47  Bit Score: 48.18  E-value: 1.08e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15227330   204 GLPPEILAKHLPIDVVTKIEELRLKSSIArrSLMPHNhhhdlsvaQDLEDQKIRRMR 260
Cdd:pfam11900   1 DLDNFCLEKELPPEVLAKIKELRLKSSLP--SLSPEL--------DDLLEKRVRRIL 47
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-118 1.19e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 49.95  E-value: 1.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  26 SDVTFSVEGRLVHAHRCILAARSLFFRKFFcgtdspqpvtgidptQHGSVPASPTrgstapagIIPVNSVGYEVFLLLLQ 105
Cdd:cd18298  13 SDLKFRVDGKYIYVHKAILKIRCEYFRSMF---------------QSHWNEDDKN--------VIEIDQYSYPVYYAFLR 69

                        90
                ....*....|...
gi 15227330 106 FLYSGQVSIVPQK 118
Cdd:cd18298  70 YLYTDQVDLPPED 82
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-114 1.23e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 50.24  E-value: 1.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  10 SLSLDFLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGTDSPQPVTgidptqhgSVPASPTrgstapagI 89
Cdd:cd18228   4 QELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVL--------VSPAGKC--------V 67

                        90       100
                ....*....|....*....|....*
gi 15227330  90 IPVNSVGYEVFLLLLQFLYSGQVSI 114
Cdd:cd18228  68 LDLHHVTVTGFAPLLEYAYTSTLSI 92
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 21-116 1.50e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 49.27  E-value: 1.50e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  21 NGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGTDSPQ-----PVTGIDPtqhgsvpasptrgstapagiipvnsv 95
Cdd:cd18314   2 NDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESnlkevTLEDVEP-------------------------- 55

                        90       100
                ....*....|....*....|.
gi 15227330  96 gyEVFLLLLQFLYSGQVSIVP 116
Cdd:cd18314  56 --EIFETVLKYMYTGQVTLSE 74
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-167 2.32e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 49.45  E-value: 2.32e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  11 LSLDFLNLLINgQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcgtdspqpvtgidptQHGSVPASPTRgstapagiI 90
Cdd:cd18279   5 LAEDLGNLWEN-SRFTDCCLCVGGQEFQAHKAILAARSPVFSAMF---------------EHEMEESKKNR--------V 60

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15227330  91 PVNSVGYEVFLLLLQFLYSGQvsiVPQKHEprpncgergcwhthcsaavdLALDTLAASRYFGVEQLALLTQKQLAS 167
Cdd:cd18279  61 EINDVDPEVFKEMMRFIYTGK---APNLDK--------------------MADDLLAAADKYALERLKVMCEDALCS 114
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-177 3.47e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 49.08  E-value: 3.47e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  14 DFLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcgtdspqpvtgidptQHGSVPASPTRgstapagiIPVN 93
Cdd:cd18345   7 DDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMF---------------EHEMEERKQNR--------VEIT 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  94 SVGYEVFLLLLQFLYSGQVsivpqkheprPNCGErgcwhthcsaavdLALDTLAASRYFGVEQLALLTQKQLASMVekaS 173
Cdd:cd18345  64 DVDHEVMREMLRFIYTGKA----------PNLDK-------------MADDLLAAADKYALERLKVMCEEALCSNL---S 117


                ....
gi 15227330 174 IEDV 177
Cdd:cd18345 118 VENV 121
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 265-358 4.44e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.97  E-value: 4.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  265 SSDVELVKLMV-MGEGLNLDESL---ALHYAVESCSREV------------------VKALLELGAaDVNYPaGPAGKTP 322
Cdd:PHA03100 118 SNSYSIVEYLLdNGANVNIKNSDgenLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGV-PINIK-DVYGFTP 195

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 15227330  323 LHIAAEMVSPDMVAVLLDHHADPNVRTVGGITPLDI 358
Cdd:PHA03100 196 LHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHI 231
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 288-356 3.05e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.49  E-value: 3.05e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  288 LHYAVESC-SREVVKALLELGAaDVNYPAGPAGKTPLHIAaeMVSPDMVAVLLDHHADPNVRTVGGITPL 356
Cdd:PHA02878 238 LHISVGYCkDYDILKLLLEHGV-DVNAKSYILGLTALHSS--IKSERKLKLLLEYGADINSLNSYKLTPL 304
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 14-112 5.42e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 44.89  E-value: 5.42e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  14 DFLNLLINgQAFSDVTFSVEGRL-VHAHRCILAARSLFFRKFFCgtdsPQPVTGIDPtqhgsvpasptrgstapagiipv 92
Cdd:cd18299   2 DLRNLLHS-PSCADVVFILQGGVrIFAHRIVLAAASSVFADLFL----MMTVVTLDS----------------------- 53

                        90       100
                ....*....|....*....|
gi 15227330  93 nSVGYEVFLLLLQFLYSGQV 112
Cdd:cd18299  54 -DITPEAFRRVLEFLYTGVL 72
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-110 1.54e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 44.58  E-value: 1.54e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  19 LINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcgtdspqpvtgidptqhgsvpaspTRGSTAPAGIIPVNSVGYE 98
Cdd:cd18351  18 FLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALL------------------------SNKPSAENTCIEISYVKYH 73

                        90
                ....*....|..
gi 15227330  99 VFLLLLQFLYSG 110
Cdd:cd18351  74 IFQLVMQYLYCG 85
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-114 1.95e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 43.81  E-value: 1.95e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  19 LINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFF---CGTDSPQPVTGIDPtqhgsvpasptrgstapagiiPVNSV 95
Cdd:cd18292  11 LYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLsndWWSESKQSEIELVE---------------------DPECA 69

                        90
                ....*....|....*....
gi 15227330  96 gyEVFLLLLQFLYSGQVSI 114
Cdd:cd18292  70 --AVFEKFLRYLYTGQISV 86
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 249-388 2.11e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.80  E-value: 2.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  249 QDLEDQKIRRMRRAlDSSDVELVKLMV-MGEGLNLDE----SLALHYAVESCSREVVKALLELGAaDVNYPaGPAGKTPL 323
Cdd:PHA02878 129 QTIDLVYIDKKSKD-DIIEAEITKLLLsYGADINMKDrhkgNTALHYATENKDQRLTELLLSYGA-NVNIP-DKTNNSPL 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  324 HIAAEMVSPDMVAVLLDHHADPNVRTVGGITPL----------DILRTLT---SDFLFKGAVPGLT--HI---EPNKLRL 385
Cdd:PHA02878 206 HHAVKHYNKPIVHILLENGASTDARDKCGNTPLhisvgyckdyDILKLLLehgVDVNAKSYILGLTalHSsikSERKLKL 285


                 ...
gi 15227330  386 CLE 388
Cdd:PHA02878 286 LLE 288
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 11-71 2.46e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 43.11  E-value: 2.46e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15227330  11 LSLDFLNLLiNGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCG------TDSPQPVTGIDPTQ 71
Cdd:cd18285   2 LSQDLLRLL-REELHTDVTFYVGSTLFKAHKAILLARVPEFFSHIIGklssleDQEPINIENLEASE 67
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 288-356 2.97e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.50  E-value: 2.97e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15227330  288 LHYAVESCSREVVKALLELGaADVNYpAGPAGKTPLHIAAEMVSPDMVAVLLDHHADPNVRTVGGITPL 356
Cdd:PHA02874 128 LHYAIKKGDLESIKMLFEYG-ADVNI-EDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-114 3.46e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 43.16  E-value: 3.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  10 SLSLDFLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGtdspqpvtGIDPTQHGSVPAsptrgstapAGI 89
Cdd:cd18256   5 SLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAG--------GMSESSKDVVQI---------HGV 67

                        90       100
                ....*....|....*....|....*
gi 15227330  90 IPvnsvgyEVFLLLLQFLYSGQVSI 114
Cdd:cd18256  68 EP------DIFHILLDFIYTGVVEV 86
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-110 4.19e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 43.30  E-value: 4.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  20 INGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGTdspqpvtgidPTQHGSvpasptrgstaPAGIIPVNSVGYEV 99
Cdd:cd18350  19 LNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNK----------SEQESQ-----------GSKTIEISDIKYHI 77

                        90
                ....*....|.
gi 15227330 100 FLLLLQFLYSG 110
Cdd:cd18350  78 FQMLMQYLYYG 88
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 319-349 4.22e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.35  E-value: 4.22e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 15227330   319 GKTPLHIAAEMV-SPDMVAVLLDHHADPNVRT 349
Cdd:pfam00023   2 GNTPLHLAAGRRgNLEIVKLLLSKGADVNARD 33
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 287-344 4.61e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.81  E-value: 4.61e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15227330  287 ALHYAVESCSREVVKALLELGAaDVNYpAGPAGKTPLHIAAEMVSPDMVAVLLDHHAD 344
Cdd:PHA03100 195 PLHYAVYNNNPEFVKYLLDLGA-NPNL-VNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 262-356 5.10e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.72  E-value: 5.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  262 ALDSSDVELVK-LMVMGEGLNLDE---SLALHYAVESCSREVVKALLELGA-ADVNypaGPAGKTPLHIAAEMVSPDMVA 336
Cdd:PHA02874 131 AIKKGDLESIKmLFEYGADVNIEDdngCYPIHIAIKHNFFDIIKLLLEKGAyANVK---DNNGESPLHNAAEYGDYACIK 207

                         90       100
                 ....*....|....*....|
gi 15227330  337 VLLDHHADPNVRTVGGITPL 356
Cdd:PHA02874 208 LLIDHGNHIMNKCKNGFTPL 227
PHA03095 PHA03095
ankyrin-like protein; Provisional
 269-398 6.19e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.40  E-value: 6.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  269 ELVKLMVMGEGLNLDESLALHYAV--ESCSREVVKALLELGAaDVNYPaGPAGKTPLHIAAEMVSPDMVAVLLDHHADPN 346
Cdd:PHA03095 207 ELIRAGCDPAATDMLGNTPLHSMAtgSSCKRSLVLPLLIAGI-SINAR-NRYGQTPLHYAAVFNNPRACRRLIALGADIN 284

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15227330  347 VRTVGGITPL---------DILRTltsdFL------------FKGAVPGLTHIEPNKLRLCL--ELVQSAAMVIS 398
Cdd:PHA03095 285 AVSSDGNTPLslmvrnnngRAVRA----ALaknpsaetvaatLNTASVAGGDIPSDATRLCVakVVLRGAFSLLP 355
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 225-356 6.75e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 45.37  E-value: 6.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  225 LRLKSSIARRSLMPHNHHHDLSVAqDLEDQkirrMRRALDSSDVELVKLMVM-GEGLN----LDESLALHYAVESCSREV 299
Cdd:PHA02875  43 MKFRDSEAIKLLMKHGAIPDVKYP-DIESE----LHDAVEEGDVKAVEELLDlGKFADdvfyKDGMTPLHLATILKKLDI 117

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 15227330  300 VKALLELGAaDVNYPAGPAgKTPLHIAAEMVSPDMVAVLLDHHADPNVRTVGGITPL 356
Cdd:PHA02875 118 MKLLIARGA-DPDIPNTDK-FSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPL 172
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-114 6.80e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 42.57  E-value: 6.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  25 FSDVTFSVEGRLVHAHRCILAARSLFFRKFFcgtdSPQPVTGIDPTQHGSVPASptrgstAPAGIIPVNSVGYEVFLLLL 104
Cdd:cd18195  18 FCDVTLIAGDTKFRAHRSVLAASSPYFRELL----SSPLPLGAAAVAAAPGATQ------SPERVLELPGVKAGVFSDVL 87

                        90
                ....*....|
gi 15227330 105 QFLYSGQVSI 114
Cdd:cd18195  88 NFIYSSRVAL 97
PHA03095 PHA03095
ankyrin-like protein; Provisional
 298-356 6.81e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.40  E-value: 6.81e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15227330  298 EVVKALLELGAaDVNYpAGPAGKTPLHI---AAEMVSPDMVAVLLDHHADPNVRTVGGITPL 356
Cdd:PHA03095  28 EEVRRLLAAGA-DVNF-RGEYGKTPLHLylhYSSEKVKDIVRLLLEAGADVNAPERCGFTPL 87
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 27-73 7.98e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 41.81  E-value: 7.98e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 15227330  27 DVTFSVEGRLVHAHRCILAARSLFFRKFFCGTDSPQPVTGIDPTQHG 73
Cdd:cd18262  20 DETVSVGGRSYGVHSVILAAVSSLFRERLLGSNGPLPPLSLEVTPVG 66
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-114 8.98e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 42.32  E-value: 8.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  25 FSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGTdspqpvtgidptqhgSVPASPTRGSTAPAgiipvnsvgyeVFLLLL 104
Cdd:cd18289  29 YCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN---------------SKSAFELPATVPPA-----------CFQQIL 82

                        90
                ....*....|
gi 15227330 105 QFLYSGQVSI 114
Cdd:cd18289  83 SFCYTGKLTM 92
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 319-347 9.36e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 9.36e-05
                           10        20
                   ....*....|....*....|....*....
gi 15227330    319 GKTPLHIAAEMVSPDMVAVLLDHHADPNV 347
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-117 9.65e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 41.89  E-value: 9.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  12 SLDFLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcgtdspqpvTG--IDPTQHgsvpasptrgstapagI 89
Cdd:cd18238   2 SFKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMF---------TSemAESKQD----------------S 56

                        90       100
                ....*....|....*....|....*...
gi 15227330  90 IPVNSVGYEVFLLLLQFLYSGQVSIVPQ 117
Cdd:cd18238  57 ITIKDIDEEAVELLVDFAYTGKLTLTVD 84
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 22-117 1.02e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 41.99  E-value: 1.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  22 GQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcgtDSPQPvtgidptQHGSVpaSPTRGSTAPAgiipvnsvgYEVFL 101
Cdd:cd18309  17 GGDFCDITLLLDGHPIPAHKAILAARCSYFEAMF---RSFMP-------EDNTV--NISIGEMVPS---------RQAFD 75

                        90
                ....*....|....*.
gi 15227330 102 LLLQFLYSGQVSIVPQ 117
Cdd:cd18309  76 SLLRYIYYGDVTMPPE 91
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 26-113 1.05e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 41.16  E-value: 1.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  26 SDVTFSVEGRLVHAHRCILAARSLFFRKFFCGTdspqpvtgidPTQHGSVPASptrgstapagiIPVNSVGYEVFLLLLQ 105
Cdd:cd18283   3 TDVDLVFQGTCFPVHRAILSARCPFFRDLLSSS----------PGYGAEIPVD-----------LPTAGIDVPMFSALLR 61


                ....*...
gi 15227330 106 FLYSGQVS 113
Cdd:cd18283  62 YLYTGEFG 69
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 16-109 1.08e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 41.37  E-value: 1.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  16 LNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGtdspqpvtgidptqhgsvpasptRGSTAPAGIIPVNSV 95
Cdd:cd18360   1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEVMAAMFNG-----------------------NYAEAKSFLVPIYGV 57

                        90
                ....*....|....
gi 15227330  96 GYEVFLLLLQFLYS 109
Cdd:cd18360  58 SKDTFLSFLEYLYT 71
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-55 1.10e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 41.53  E-value: 1.10e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15227330  13 LDFLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFF 55
Cdd:cd18221   6 LDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFF 48
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-160 1.22e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 41.70  E-value: 1.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  21 NGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGTDSPqpvtgiDPTQHgsvpasptrgstapagIIPVNSVGYEVF 100
Cdd:cd18293  11 NSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPP------AGQKV----------------VLELQGLKAHTL 68

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330 101 LLLLQFLYSGQVSIVPQKheprpncgergcwhthcsaavdlALDTLAASRYFGVEQLALL 160
Cdd:cd18293  69 LKLVDFLYTSELEVSSEE-----------------------AQDVLAAARRLQISELESL 105
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-167 1.72e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 41.14  E-value: 1.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  11 LSLDFLNLLINGQaFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcgtdspqpvtgidptQHGSVPASPTRgstapagiI 90
Cdd:cd18343   8 LAEDLGNLWENSR-FTDCSLFVGGQEFKAHKSILAARSPVFNAMF---------------EHEMEESKKNR--------V 63

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 15227330  91 PVNSVGYEVFLLLLQFLYSGQVsivpqkheprPNCGErgcwhthcsaavdLALDTLAASRYFGVEQLALLTQKQLAS 167
Cdd:cd18343  64 EINDVDPEVFKEMMRFIYTGKA----------PNLDK-------------MADNLLAAADKYALERLKVMCEEALCN 117
BTB1_POZ_LZTR1 cd18308
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 14-124 2.01e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349617 [Multi-domain]  Cd Length: 156  Bit Score: 41.98  E-value: 2.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  14 DFLNLLINGQaFSDVTFSV--EGRLVHAHRCILAARSLFFR-KFFCGTDSPQPVTGIDPTQHGSVPASPTRGSTAPAGI- 89
Cdd:cd18308  13 DFGRLLESRQ-FCDVEFIVgeEEERIPAHIAFVAARSKWLRnKILQARERQKQKAEQEVEDEGSEADSSSASKNDSPMLe 91

                        90       100       110
                ....*....|....*....|....*....|....*
gi 15227330  90 IPVNSVGYEVFLLLLQFLYSGQVSIVPQKHEPRPN 124
Cdd:cd18308  92 VRLPEADPEAFELILSFIYTDKIDPTRKGQDPGSN 126
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-57 2.13e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 41.28  E-value: 2.13e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 15227330  12 SLDFLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCG 57
Cdd:cd18249  10 TLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTG 55
Ank_4 pfam13637
Ankyrin repeats (many copies);
284-339 2.37e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 2.37e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 15227330   284 ESLALHYAVESCSREVVKALLELGaADVNYPAGpAGKTPLHIAAEMVSPDMVAVLL 339
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKG-ADINAVDG-NGETALHFAASNGNVEVLKLLL 54
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-114 2.41e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 41.42  E-value: 2.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  16 LNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcgtdspqpvtgidptqhgsvpASPTRgsTAPAGIIPVNSV 95
Cdd:cd18272  23 MDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMF---------------------TSNLK--EARNRVIELKDV 79

                        90
                ....*....|....*....
gi 15227330  96 GYEVFLLLLQFLYSGQVSI 114
Cdd:cd18272  80 SESVFQLLVDYIYHGTVKL 98
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 262-356 3.01e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.06  E-value: 3.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  262 ALDSSDVELVKLMvMGEGLNLDESLA-----LHYAVESCSREVVKALLELG--AADVNYPAGpagKTPLHIAAEMVSPDM 334
Cdd:PHA02875  42 AMKFRDSEAIKLL-MKHGAIPDVKYPdieseLHDAVEEGDVKAVEELLDLGkfADDVFYKDG---MTPLHLATILKKLDI 117

                         90       100
                 ....*....|....*....|..
gi 15227330  335 VAVLLDHHADPNVRTVGGITPL 356
Cdd:PHA02875 118 MKLLIARGADPDIPNTDKFSPL 139
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-114 3.27e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 40.30  E-value: 3.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  25 FSDVTFSVEGRLVHAHRCILAARSLFFRKFFcgtdspqpVTGIDPTQhgsvpasptRGSTAPAGIipvnsVGYEVFLLLL 104
Cdd:cd18330  18 FCDCSIIVEGRIFKAHRNILFANSGYFRALL--------IHYIQDSG---------RHSTASLDI-----VTSEAFSIIL 75

                        90
                ....*....|
gi 15227330 105 QFLYSGQVSI 114
Cdd:cd18330  76 DFLYSGKLDL 85
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 280-364 3.53e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 42.73  E-value: 3.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  280 LNLDESLALHYAVESCSREVVKALLELGA----ADVNYpagpagKTPLHIAAEMVS-----PDMVAVLLDHHADPNVRTV 350
Cdd:PHA03100  31 SYKKPVLPLYLAKEARNIDVVKILLDNGAdinsSTKNN------STPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDN 104

                         90
                 ....*....|....
gi 15227330  351 GGITPLDILRTLTS 364
Cdd:PHA03100 105 NGITPLLYAISKKS 118
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-116 4.24e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 40.02  E-value: 4.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  16 LNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFcgtDSPQPVTGIDPTQhgsvpasptrgstapagiIPVNSV 95
Cdd:cd18245   5 LNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKL---NYNPPKDDGSTYK------------------IELEGI 63

                        90       100
                ....*....|....*....|.
gi 15227330  96 GYEVFLLLLQFLYSGQVSIVP 116
Cdd:cd18245  64 SVEVMEEILDYIYTGQIKLSE 84
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-114 4.52e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 40.20  E-value: 4.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  13 LDFLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCG--TDSPQPVTGIDptqhgsvpasptrgstapaGII 90
Cdd:cd18253   6 LQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNdhRESREMLVEIN-------------------GIL 66

                        90       100
                ....*....|....*....|....
gi 15227330  91 PvnsvgyEVFLLLLQFLYSGQVSI 114
Cdd:cd18253  67 A------EAMDCFLQYVYTGKVKI 84
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 27-113 5.85e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 39.80  E-value: 5.85e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  27 DVTFSVEGRLVHAHRCILAARSLFFRKFFCgtdspqpvTGIDPTQHGSVPAsPTrgstapagiIPVNSVGyevflLLLQF 106
Cdd:cd18263  15 DVQLEADGSIFRVHRVILAAGSDYFRAMFT--------SGMKESTQSVVQL-PT---------IPAKDLR-----LLISF 71


                ....*..
gi 15227330 107 LYSGQVS 113
Cdd:cd18263  72 AYSGILH 78
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-55 6.16e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 40.02  E-value: 6.16e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15227330  16 LNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFF 55
Cdd:cd18243  23 LNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF 62
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 319-347 9.06e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.85  E-value: 9.06e-04
                          10        20
                  ....*....|....*....|....*....
gi 15227330   319 GKTPLHIAAEMVSPDMVAVLLDHHADPNV 347
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-56 1.01e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 38.66  E-value: 1.01e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 15227330  25 FSDVTFSVEGRLVHAHRCILAARSLFFRKFFC 56
Cdd:cd18219  21 FCDVTVIVEDRKFRAHKNILSASSTYFHQLFS 52
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-117 1.20e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 38.78  E-value: 1.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  25 FSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGTDSpqpvtgidptqhgsvpASPTRGSTAPAGIIPVNSvgyevFLLLL 104
Cdd:cd18201  21 LCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNK----------------ESCDQTTVTHLDVVAVQG-----FSVIL 79

                        90
                ....*....|...
gi 15227330 105 QFLYSGQVSIVPQ 117
Cdd:cd18201  80 DFMYSGNLVLTSQ 92
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-114 1.26e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 39.03  E-value: 1.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  13 LDFLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGtdspqpvtGIDPTQHGSVpasptrgstapagiiPV 92
Cdd:cd18251  11 LDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAG--------GLREMQQTEV---------------LI 67

                        90       100
                ....*....|....*....|..
gi 15227330  93 NSVGYEVFLLLLQFLYSGQVSI 114
Cdd:cd18251  68 HGVSYNAMCKILDFIYTSELEL 89
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 288-392 1.87e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 40.35  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  288 LHYAVESCSREVVKALLELGAaDVNYPAGPAGKTPLHIAAEMVSPDMVAVLLDHHADPNVRTVGGITPLDILRTLTSDFL 367
Cdd:PHA02884  74 LIYAIDCDNDDAAKLLIRYGA-DVNRYAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIELALMICNNFL 152

                         90       100
                 ....*....|....*....|....*...
gi 15227330  368 ---FKGAVPGLTHIEPNKLRLCLELVQS 392
Cdd:PHA02884 153 afmICDNEISNFYKHPKKILINFDILKI 180
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-55 2.31e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 37.91  E-value: 2.31e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15227330  13 LDFLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFF 55
Cdd:cd18202   7 LDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELF 49
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-69 2.90e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 37.84  E-value: 2.90e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330   5 EESLRSLSLDFLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGT--DSPQP---VTGIDP 69
Cdd:cd18268   3 DQDLSSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNfrESSQAkvdLKGIDS 72
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 256-344 2.93e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.00  E-value: 2.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330 256 IRRMRRALDSSDVELVKLMVMGEGlnldeslALHYAVESCSREVVKALLELGAADVNYPAGP---AGKTPLHIAAEMVSP 332
Cdd:cd22192  30 VQAIKKLLKCPSCDLFQRGALGET-------ALHVAALYDNLEAAVVLMEAAPELVNEPMTSdlyQGETALHIAVVNQNL 102

                        90
                ....*....|..
gi 15227330 333 DMVAVLLDHHAD 344
Cdd:cd22192 103 NLVRELIARGAD 114
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-52 3.70e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 37.35  E-value: 3.70e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15227330  13 LDFLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFR 52
Cdd:cd18208  13 LETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQ 52
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-55 3.96e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 37.50  E-value: 3.96e-03
                        10        20        30
                ....*....|....*....|....*....|...
gi 15227330  23 QAFSDVTFSVEGRLVHAHRCILAARSLFFRKFF 55
Cdd:cd18271  22 NAFFDFNIIVKDETIPCHRCVLAACSDFFRAMF 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 319-356 4.12e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 39.85  E-value: 4.12e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 15227330  319 GKTPLHIAAEMVSPDMVAVLLDHHADPNVRTVGGITPL 356
Cdd:PLN03192 558 GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTAL 595
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-120 5.10e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 37.66  E-value: 5.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330  13 LDFLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGtdspqpvtGIDPTQHGSVPASptrgstapagiipv 92
Cdd:cd18267  28 LTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSG--------GLKESQDSEVNFH-------------- 85

                        90       100
                ....*....|....*....|....*...
gi 15227330  93 NSVGYEVFLLLLQFLYSGQVSIVPQKHE 120
Cdd:cd18267  86 DSIHPEVLELLLDYAYSSRVIINEENAE 113
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 25-55 5.17e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 36.96  E-value: 5.17e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 15227330  25 FSDVTF-SVEGRLVHAHRCILAARSLFFRKFF 55
Cdd:cd18302   5 LYDVTIvSEDGKEFPCHKCVLVARLEYFHSML 36
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-57 5.26e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 37.50  E-value: 5.26e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15227330  13 LDFLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCG 57
Cdd:cd18259  20 LDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTG 64
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-52 5.73e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 36.76  E-value: 5.73e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 15227330  13 LDFLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFR 52
Cdd:cd18229   6 LETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFH 45
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-55 6.24e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 36.69  E-value: 6.24e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 15227330  24 AFSDVTFSVEGRLVHAHRCILAARSLFFRKFF 55
Cdd:cd18223  17 ILCDVTIVVEDTKFKAHKNVLAASSLYFKNAF 48
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 287-346 6.35e-03

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 39.29  E-value: 6.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15227330   287 ALHYAVESCSREVVKALLELGaADVNYPAGPA-------------GKTPLHIAAEMVSPDMVAVLLDHHADPN 346
Cdd:TIGR00870 131 ALHLAAHRQNYEIVKLLLERG-ASVPARACGDffvksqgvdsfyhGESPLNAAACLGSPSIVALLSEDPADIL 202
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 269-359 7.78e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 38.84  E-value: 7.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15227330 269 ELVKlMVMGEGLNLDESlALHYAVESCSREVVKALLELGAaDVNYP--------AGPA-----GKTPLHIAAEMVSPDMV 335
Cdd:cd22192  76 ELVN-EPMTSDLYQGET-ALHIAVVNQNLNLVRELIARGA-DVVSPratgtffrPGPKnliyyGEHPLSFAACVGNEEIV 152

                        90       100
                ....*....|....*....|....
gi 15227330 336 AVLLDHHADPNVRTVGGITPLDIL 359
Cdd:cd22192 153 RLLIEHGADIRAQDSLGNTVLHIL 176
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-57 7.89e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 36.70  E-value: 7.89e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 15227330  27 DVTFSVEGRLVHAHRCILAARSLFFRKFFCG 57
Cdd:cd18237  23 DVILIVEGREIKAHRVVLAAASHFFHLMFTS 53
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-57 9.95e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 35.98  E-value: 9.95e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 15227330  16 LNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCG 57
Cdd:cd18257   9 LNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTG 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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