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Conserved domains on  [gi|30688500|ref|NP_181635|]
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WW domain-containing protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRP40 super family cl34905
Splicing factor [RNA processing and modification];
188-296 3.44e-10

Splicing factor [RNA processing and modification];


The actual alignment was detected with superfamily member COG5104:

Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 62.02  E-value: 3.44e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688500 188 QANASTLPLG-----WVDAKDPaSGATYYYNQHTGTCQWERPVELsyaTSSAPPVLSKEEWIEtFDEASGHKYFYNTRTH 262
Cdd:COG5104   2 QAALLGMASGearseWEELKAP-DGRIYYYNKRTGKSSWEKPKEL---LKGSEEDLDVDPWKE-CRTADGKVYYYNSITR 76

                        90       100       110
                ....*....|....*....|....*....|....
gi 30688500 263 VSQWEPPASLQKPAATNSNNAVTQSTANGKGEHP 296
Cdd:COG5104  77 ESRWKIPPERKKVEPIAEQKHDERSMIGGNGNDM 110
 
Name Accession Description Interval E-value
PRP40 COG5104
Splicing factor [RNA processing and modification];
188-296 3.44e-10

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 62.02  E-value: 3.44e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688500 188 QANASTLPLG-----WVDAKDPaSGATYYYNQHTGTCQWERPVELsyaTSSAPPVLSKEEWIEtFDEASGHKYFYNTRTH 262
Cdd:COG5104   2 QAALLGMASGearseWEELKAP-DGRIYYYNKRTGKSSWEKPKEL---LKGSEEDLDVDPWKE-CRTADGKVYYYNSITR 76

                        90       100       110
                ....*....|....*....|....*....|....
gi 30688500 263 VSQWEPPASLQKPAATNSNNAVTQSTANGKGEHP 296
Cdd:COG5104  77 ESRWKIPPERKKVEPIAEQKHDERSMIGGNGNDM 110
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 194-224 1.95e-08

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 49.81  E-value: 1.95e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 30688500   194 LPLGWVDAKDPaSGATYYYNQHTGTCQWERP 224
Cdd:pfam00397   1 LPPGWEERWDP-DGRVYYYNHETGETQWEKP 30
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 193-226 5.30e-08

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 48.75  E-value: 5.30e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 30688500    193 TLPLGWVDAKDPaSGATYYYNQHTGTCQWERPVE 226
Cdd:smart00456   1 PLPPGWEERKDP-DGRPYYYNHETKETQWEKPRE 33
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 195-226 3.50e-07

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 46.37  E-value: 3.50e-07
                        10        20        30
                ....*....|....*....|....*....|..
gi 30688500 195 PLGWVDAKDPaSGATYYYNQHTGTCQWERPVE 226
Cdd:cd00201   1 PPGWEERWDP-DGRVYYYNHNTKETQWEDPRE 31
 
Name Accession Description Interval E-value
PRP40 COG5104
Splicing factor [RNA processing and modification];
188-296 3.44e-10

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 62.02  E-value: 3.44e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30688500 188 QANASTLPLG-----WVDAKDPaSGATYYYNQHTGTCQWERPVELsyaTSSAPPVLSKEEWIEtFDEASGHKYFYNTRTH 262
Cdd:COG5104   2 QAALLGMASGearseWEELKAP-DGRIYYYNKRTGKSSWEKPKEL---LKGSEEDLDVDPWKE-CRTADGKVYYYNSITR 76

                        90       100       110
                ....*....|....*....|....*....|....
gi 30688500 263 VSQWEPPASLQKPAATNSNNAVTQSTANGKGEHP 296
Cdd:COG5104  77 ESRWKIPPERKKVEPIAEQKHDERSMIGGNGNDM 110
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 194-224 1.95e-08

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 49.81  E-value: 1.95e-08
                          10        20        30
                  ....*....|....*....|....*....|.
gi 30688500   194 LPLGWVDAKDPaSGATYYYNQHTGTCQWERP 224
Cdd:pfam00397   1 LPPGWEERWDP-DGRVYYYNHETGETQWEKP 30
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 193-226 5.30e-08

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 48.75  E-value: 5.30e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 30688500    193 TLPLGWVDAKDPaSGATYYYNQHTGTCQWERPVE 226
Cdd:smart00456   1 PLPPGWEERKDP-DGRPYYYNHETKETQWEKPRE 33
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 195-226 3.50e-07

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 46.37  E-value: 3.50e-07
                        10        20        30
                ....*....|....*....|....*....|..
gi 30688500 195 PLGWVDAKDPaSGATYYYNQHTGTCQWERPVE 226
Cdd:cd00201   1 PPGWEERWDP-DGRVYYYNHNTKETQWEDPRE 31
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 241-269 5.61e-07

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 45.57  E-value: 5.61e-07
                          10        20
                  ....*....|....*....|....*....
gi 30688500   241 EEWIETFDEaSGHKYFYNTRTHVSQWEPP 269
Cdd:pfam00397   3 PGWEERWDP-DGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 240-269 6.95e-06

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 42.52  E-value: 6.95e-06
                        10        20        30
                ....*....|....*....|....*....|
gi 30688500 240 KEEWIETFDEaSGHKYFYNTRTHVSQWEPP 269
Cdd:cd00201   1 PPGWEERWDP-DGRVYYYNHNTKETQWEDP 29
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 239-271 1.15e-05

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 41.82  E-value: 1.15e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 30688500    239 SKEEWIETFDEaSGHKYFYNTRTHVSQWEPPAS 271
Cdd:smart00456   2 LPPGWEERKDP-DGRPYYYNHETKETQWEKPRE 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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