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Conserved domains on  [gi|15225344|ref|NP_179623|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-491 1.96e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 163.27  E-value: 1.96e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 172 QLKGHTKIVSSLAVDSAGARVLSGSYDYTVRMYDFQGMnsrlQSFRQIepsEGHQ--VRSVSWSPTSGQFLCVTGSAQAK 249
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG----ELLRTL---KGHTgpVRDVAASADGTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 250 IFDRDGLTLgefmkgdmyIRDLkntKGHICGLTCGEWHPrTKETVLTSSEDGSLRIWDVNNFlSQTQVIKPKLArpgrvP 329
Cdd:cd00200  77 LWDLETGEC---------VRTL---TGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETG-KCLTTLRGHTD-----W 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 330 VTTCAWDRDGKRIAGGVGDGSIQIWSLKPGwgsRPdIYVGKAHTDDITSVKFSSDGRILLSRSFDGSLKVWDLRqMKEAL 409
Cdd:cd00200 138 VNSVAFSPDGTFVASSSQDGTIKLWDLRTG---KC-VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS-TGKCL 212

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 410 KVFEGLPNYYpqTNVAFSPDEQIILTGTsveKDSTtgglLCFYDRTKLEIVQKVGiSPTSSVVQCAWHPRLNQIFATSGD 489
Cdd:cd00200 213 GTLRGHENGV--NSVAFSPDGYLLASGS---EDGT----IRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSAD 282


                ..
gi 15225344 490 KS 491
Cdd:cd00200 283 GT 284
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-491 1.96e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 163.27  E-value: 1.96e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 172 QLKGHTKIVSSLAVDSAGARVLSGSYDYTVRMYDFQGMnsrlQSFRQIepsEGHQ--VRSVSWSPTSGQFLCVTGSAQAK 249
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG----ELLRTL---KGHTgpVRDVAASADGTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 250 IFDRDGLTLgefmkgdmyIRDLkntKGHICGLTCGEWHPrTKETVLTSSEDGSLRIWDVNNFlSQTQVIKPKLArpgrvP 329
Cdd:cd00200  77 LWDLETGEC---------VRTL---TGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETG-KCLTTLRGHTD-----W 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 330 VTTCAWDRDGKRIAGGVGDGSIQIWSLKPGwgsRPdIYVGKAHTDDITSVKFSSDGRILLSRSFDGSLKVWDLRqMKEAL 409
Cdd:cd00200 138 VNSVAFSPDGTFVASSSQDGTIKLWDLRTG---KC-VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS-TGKCL 212

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 410 KVFEGLPNYYpqTNVAFSPDEQIILTGTsveKDSTtgglLCFYDRTKLEIVQKVGiSPTSSVVQCAWHPRLNQIFATSGD 489
Cdd:cd00200 213 GTLRGHENGV--NSVAFSPDGYLLASGS---EDGT----IRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSAD 282


                ..
gi 15225344 490 KS 491
Cdd:cd00200 283 GT 284
WD40 COG2319
WD40 repeat [General function prediction only];
172-491 1.99e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.45  E-value: 1.99e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 172 QLKGHTKIVSSLAVDSAGARVLSGSYDYTVRMYDfqgmnsrLQSFRQIEPSEGHQ--VRSVSWSPtSGQFLcVTGSA--Q 247
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD-------LATGKLLRTLTGHSgaVTSVAFSP-DGKLL-ASGSDdgT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 248 AKIFDRDGLTLgefmkgdmyirdLKNTKGHICGLTCGEWHPRTKeTVLTSSEDGSLRIWDVnnflsQTQVIKPKLARPGR 327
Cdd:COG2319 186 VRLWDLATGKL------------LRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDL-----ATGKLLRTLTGHSG 247

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 328 vPVTTCAWDRDGKRIAGGVGDGSIQIWSLKPGwgsrPDIYVGKAHTDDITSVKFSSDGRILLSRSFDGSLKVWDLRQmKE 407
Cdd:COG2319 248 -SVRSVAFSPDGRLLASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-GK 321

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 408 ALKVFEGlpNYYPQTNVAFSPDEQIILTGTSvekdsttGGLLCFYDRTKLEIVQKVGiSPTSSVVQCAWHPRLNQIFATS 487
Cdd:COG2319 322 LLRTLTG--HTGAVRSVAFSPDGKTLASGSD-------DGTVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGS 391


                ....
gi 15225344 488 GDKS 491
Cdd:COG2319 392 ADGT 395
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 366-401 1.18e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.18e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 15225344    366 IYVGKAHTDDITSVKFSSDGRILLSRSFDGSLKVWD 401
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
366-401 4.64e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 4.64e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 15225344   366 IYVGKAHTDDITSVKFSSDGRILLSRSFDGSLKVWD 401
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 286-406 8.00e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 8.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344  286 WHPRTKETVLTSSEDGSLRIWDVnnflSQTQVIKPKLARPGRVpvttcaW-----DRDGKRIAGGVGDGSIQIWSLKPGw 360
Cdd:PLN00181 540 WNSYIKSQVASSNFEGVVQVWDV----ARSQLVTEMKEHEKRV------WsidysSADPTLLASGSDDGSVKLWSINQG- 608

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 15225344  361 gsrpdIYVGKAHTD-DITSVKFSSD-GRILLSRSFDGSLKVWDLRQMK 406
Cdd:PLN00181 609 -----VSIGTIKTKaNICCVQFPSEsGRSLAFGSADHKVYYYDLRNPK 651
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-491 1.96e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 163.27  E-value: 1.96e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 172 QLKGHTKIVSSLAVDSAGARVLSGSYDYTVRMYDFQGMnsrlQSFRQIepsEGHQ--VRSVSWSPTSGQFLCVTGSAQAK 249
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG----ELLRTL---KGHTgpVRDVAASADGTYLASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 250 IFDRDGLTLgefmkgdmyIRDLkntKGHICGLTCGEWHPrTKETVLTSSEDGSLRIWDVNNFlSQTQVIKPKLArpgrvP 329
Cdd:cd00200  77 LWDLETGEC---------VRTL---TGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETG-KCLTTLRGHTD-----W 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 330 VTTCAWDRDGKRIAGGVGDGSIQIWSLKPGwgsRPdIYVGKAHTDDITSVKFSSDGRILLSRSFDGSLKVWDLRqMKEAL 409
Cdd:cd00200 138 VNSVAFSPDGTFVASSSQDGTIKLWDLRTG---KC-VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS-TGKCL 212

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 410 KVFEGLPNYYpqTNVAFSPDEQIILTGTsveKDSTtgglLCFYDRTKLEIVQKVGiSPTSSVVQCAWHPRLNQIFATSGD 489
Cdd:cd00200 213 GTLRGHENGV--NSVAFSPDGYLLASGS---EDGT----IRVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSAD 282


                ..
gi 15225344 490 KS 491
Cdd:cd00200 283 GT 284
WD40 COG2319
WD40 repeat [General function prediction only];
172-491 1.99e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.45  E-value: 1.99e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 172 QLKGHTKIVSSLAVDSAGARVLSGSYDYTVRMYDfqgmnsrLQSFRQIEPSEGHQ--VRSVSWSPtSGQFLcVTGSA--Q 247
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD-------LATGKLLRTLTGHSgaVTSVAFSP-DGKLL-ASGSDdgT 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 248 AKIFDRDGLTLgefmkgdmyirdLKNTKGHICGLTCGEWHPRTKeTVLTSSEDGSLRIWDVnnflsQTQVIKPKLARPGR 327
Cdd:COG2319 186 VRLWDLATGKL------------LRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDL-----ATGKLLRTLTGHSG 247

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 328 vPVTTCAWDRDGKRIAGGVGDGSIQIWSLKPGwgsrPDIYVGKAHTDDITSVKFSSDGRILLSRSFDGSLKVWDLRQmKE 407
Cdd:COG2319 248 -SVRSVAFSPDGRLLASGSADGTVRLWDLATG----ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT-GK 321

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 408 ALKVFEGlpNYYPQTNVAFSPDEQIILTGTSvekdsttGGLLCFYDRTKLEIVQKVGiSPTSSVVQCAWHPRLNQIFATS 487
Cdd:COG2319 322 LLRTLTG--HTGAVRSVAFSPDGKTLASGSD-------DGTVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGS 391


                ....
gi 15225344 488 GDKS 491
Cdd:COG2319 392 ADGT 395
WD40 COG2319
WD40 repeat [General function prediction only];
172-491 1.54e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.59  E-value: 1.54e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 172 QLKGHTKIVSSLAVDSAGARVLSGSYDYTVRMYDfqgmnsrLQSFRQIEPSEGHQ--VRSVSWSPtSGQFLcVTGSA--Q 247
Cdd:COG2319  73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWD-------LATGLLLRTLTGHTgaVRSVAFSP-DGKTL-ASGSAdgT 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 248 AKIFDRDGLTLgefmkgdmyirdLKNTKGHICGLTCGEWHPrTKETVLTSSEDGSLRIWDVNNflsqTQVIKPKLARPGr 327
Cdd:COG2319 144 VRLWDLATGKL------------LRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLAT----GKLLRTLTGHTG- 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 328 vPVTTCAWDRDGKRIAGGVGDGSIQIWSLKPGwgsrPDIYVGKAHTDDITSVKFSSDGRILLSRSFDGSLKVWDLRQmKE 407
Cdd:COG2319 206 -AVRSVAFSPDGKLLASGSADGTVRLWDLATG----KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT-GE 279

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 408 ALKVFEGLPNyyPQTNVAFSPDEQIILTGTSvekDSTtgglLCFYDRTKLEIVQKVGiSPTSSVVQCAWHPRLNQIFATS 487
Cdd:COG2319 280 LLRTLTGHSG--GVNSVAFSPDGKLLASGSD---DGT----VRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGS 349


                ....
gi 15225344 488 GDKS 491
Cdd:COG2319 350 DDGT 353
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 170-436 1.13e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.93  E-value: 1.13e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 170 EIQLKGHTKIVSSLAVDSAGARVLSGSYDYTVRMYDFQGmNSRLQSFrqiepsEGHQ--VRSVSWSPtSGQFLCVTGS-A 246
Cdd:cd00200  44 LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET-GECVRTL------TGHTsyVSSVAFSP-DGRILSSSSRdK 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 247 QAKIFDrdgLTLGEFmkgdmyirdLKNTKGHICGLTCGEWHPrTKETVLTSSEDGSLRIWDVNNFlsqtqviKPKLARPG 326
Cdd:cd00200 116 TIKVWD---VETGKC---------LTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTG-------KCVATLTG 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 327 -RVPVTTCAWDRDGKRIAGGVGDGSIQIWSLKPGWgsrpDIYVGKAHTDDITSVKFSSDGRILLSRSFDGSLKVWDLRqM 405
Cdd:cd00200 176 hTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK----CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR-T 250

                       250       260       270
                ....*....|....*....|....*....|.
gi 15225344 406 KEALKVFEGLPNyyPQTNVAFSPDEQIILTG 436
Cdd:cd00200 251 GECVQTLSGHTN--SVTSLAWSPDGKRLASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
173-403 2.48e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.04  E-value: 2.48e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 173 LKGHTKIVSSLAVDSAGARVLSGSYDYTVRMYDfqgmnsrLQSFRQIEPSEGHQ--VRSVSWSPtSGQFLcVTGSA--QA 248
Cdd:COG2319 200 LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD-------LATGKLLRTLTGHSgsVRSVAFSP-DGRLL-ASGSAdgTV 270

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 249 KIFDRDGLTLgefmkgdmyirdLKNTKGHICGLTCGEWHPRTKeTVLTSSEDGSLRIWDVNNflsqtqvikPKLARP--- 325
Cdd:COG2319 271 RLWDLATGEL------------LRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLAT---------GKLLRTltg 328

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 15225344 326 GRVPVTTCAWDRDGKRIAGGVGDGSIQIWSLKPGWgsrpDIYVGKAHTDDITSVKFSSDGRILLSRSFDGSLKVWDLR 403
Cdd:COG2319 329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE----LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
293-491 3.68e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.05  E-value: 3.68e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 293 TVLTSSEDGSLRIWDVnnflsqTQVIKPKLARPGRVPVTTCAWDRDGKRIAGGVGDGSIQIWSLKPGWGSRPdiyvGKAH 372
Cdd:COG2319  50 RLAAGAGDLTLLLLDA------AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT----LTGH 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 373 TDDITSVKFSSDGRILLSRSFDGSLKVWDLRQmKEALKVFEGLPNyyPQTNVAFSPDEQIILTGTSvekDSTtgglLCFY 452
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-GKLLRTLTGHSG--AVTSVAFSPDGKLLASGSD---DGT----VRLW 189

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 15225344 453 DRTKLEIVQKVGiSPTSSVVQCAWHPRLNQIFATSGDKS 491
Cdd:COG2319 190 DLATGKLLRTLT-GHTGAVRSVAFSPDGKLLASGSADGT 227
WD40 COG2319
WD40 repeat [General function prediction only];
173-310 1.48e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 1.48e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 173 LKGHTKIVSSLAVDSAGARVLSGSYDYTVRMYDfqgmnsrLQSFRQIEPSEGH--QVRSVSWSPTsGQFLcVTGSAQ--A 248
Cdd:COG2319 284 LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD-------LATGKLLRTLTGHtgAVRSVAFSPD-GKTL-ASGSDDgtV 354

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15225344 249 KIFDRDGLTLgefmkgdmyirdLKNTKGHICGLTCGEWHPRTKeTVLTSSEDGSLRIWDVNN 310
Cdd:COG2319 355 RLWDLATGEL------------LRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
322-489 4.87e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 4.87e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 322 LARPGRVPVTTCAWDRDGKRIAGGVGDGSIQIWSLKPGWGSRPdiyvGKAHTDDITSVKFSSDGRILLSRSFDGSLKVWD 401
Cdd:COG2319  31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLAT----LLGHTAAVLSVAFSPDGRLLASASADGTVRLWD 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344 402 LRQmKEALKVFEGLPNYYpqTNVAFSPDEQIILTGTSvekDSTtgglLCFYDRTKLEIVQKVGiSPTSSVVQCAWHPRlN 481
Cdd:COG2319 107 LAT-GLLLRTLTGHTGAV--RSVAFSPDGKTLASGSA---DGT----VRLWDLATGKLLRTLT-GHSGAVTSVAFSPD-G 174


                ....*...
gi 15225344 482 QIFATSGD 489
Cdd:COG2319 175 KLLASGSD 182
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 366-401 1.18e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.18e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 15225344    366 IYVGKAHTDDITSVKFSSDGRILLSRSFDGSLKVWD 401
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
366-401 4.64e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 4.64e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 15225344   366 IYVGKAHTDDITSVKFSSDGRILLSRSFDGSLKVWD 401
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 173-205 4.14e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 4.14e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 15225344    173 LKGHTKIVSSLAVDSAGARVLSGSYDYTVRMYD 205
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
173-205 5.26e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 5.26e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 15225344   173 LKGHTKIVSSLAVDSAGARVLSGSYDYTVRMYD 205
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 286-406 8.00e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 8.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344  286 WHPRTKETVLTSSEDGSLRIWDVnnflSQTQVIKPKLARPGRVpvttcaW-----DRDGKRIAGGVGDGSIQIWSLKPGw 360
Cdd:PLN00181 540 WNSYIKSQVASSNFEGVVQVWDV----ARSQLVTEMKEHEKRV------WsidysSADPTLLASGSDDGSVKLWSINQG- 608

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 15225344  361 gsrpdIYVGKAHTD-DITSVKFSSD-GRILLSRSFDGSLKVWDLRQMK 406
Cdd:PLN00181 609 -----VSIGTIKTKaNICCVQFPSEsGRSLAFGSADHKVYYYDLRNPK 651
PTZ00420 PTZ00420
coronin; Provisional
 171-409 3.21e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.79  E-value: 3.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344  171 IQLKGHTKIVSSLAVDSAGARVL-SGSYDYTVRMYDFqgmnsrlqsfrqiePSEGHQVRSVSwSPtsgqfLCVTgsaqak 249
Cdd:PTZ00420  68 IKLKGHTSSILDLQFNPCFSEILaSGSEDLTIRVWEI--------------PHNDESVKEIK-DP-----QCIL------ 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344  250 ifdrdgltlgefmkgdmyirdlkntKGHICGLTCGEWHPRTKETVLTSSEDGSLRIWDVNNFLSQTQVIKPKlarpgrvP 329
Cdd:PTZ00420 122 -------------------------KGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMPK-------K 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15225344  330 VTTCAWDRDGKRIAGGVGDGSIQIWS-LKPGWGSRPDIYVGKAHTDDITSVKFSSDGRILLSRSFDGS----LKVWDLRQ 404
Cdd:PTZ00420 170 LSSLKWNIKGNLLSGTCVGKHMHIIDpRKQEIASSFHIHDGGKNTKNIWIDGLGGDDNYILSTGFSKNnmreMKLWDLKN 249


                 ....*
gi 15225344  405 MKEAL 409
Cdd:PTZ00420 250 TTSAL 254
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 275-307 6.32e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 6.32e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 15225344    275 KGHICGLTCGEWHPRTKeTVLTSSEDGSLRIWD 307
Cdd:smart00320   9 KGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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