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Conserved domains on  [gi|15224404|ref|NP_178558|]
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F-box only protein (DUF295) [Arabidopsis thaliana]

Protein Classification

F-box protein( domain architecture ID 10459082)

F-box protein containing a DUF295 domain, may function as the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0019005|GO:0005515
PubMed:  31898225|11178263
SCOP:  4001927

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF295 pfam03478
Protein of unknown function (DUF295); This domain is found in plant proteins of unknown ...
311-370 3.36e-07

Protein of unknown function (DUF295); This domain is found in plant proteins of unknown function. It can be found in association with F-box domain pfam00646.


:

Pssm-ID: 460939 [Multi-domain]  Cd Length: 57  Bit Score: 46.82  E-value: 3.36e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15224404   311 ERVYCIGDEMLIFGRGVT-ALALEDLDdGIKSNSIYFVGEDvwpDHQEHEHRVSNCGFFDI 370
Cdd:pfam03478   1 VEVKSLGDRALFLGRNCSlSVSASDFP-GLKGNCIYFLTDD---DDEVYKDEGRDIGVYDL 57
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
22-60 3.37e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 425796  Cd Length: 43  Bit Score: 35.21  E-value: 3.37e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15224404    22 WSKLCPDVLRKIYETLrSPVDSHRAKIVCSNWYSVWKTC 60
Cdd:pfam00646   1 LLDLPDDLLLEILSRL-DPKDLLRLSLVSKRWRSLVDSL 38
 
Name Accession Description Interval E-value
DUF295 pfam03478
Protein of unknown function (DUF295); This domain is found in plant proteins of unknown ...
311-370 3.36e-07

Protein of unknown function (DUF295); This domain is found in plant proteins of unknown function. It can be found in association with F-box domain pfam00646.


Pssm-ID: 460939 [Multi-domain]  Cd Length: 57  Bit Score: 46.82  E-value: 3.36e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15224404   311 ERVYCIGDEMLIFGRGVT-ALALEDLDdGIKSNSIYFVGEDvwpDHQEHEHRVSNCGFFDI 370
Cdd:pfam03478   1 VEVKSLGDRALFLGRNCSlSVSASDFP-GLKGNCIYFLTDD---DDEVYKDEGRDIGVYDL 57
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
22-60 3.37e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 35.21  E-value: 3.37e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15224404    22 WSKLCPDVLRKIYETLrSPVDSHRAKIVCSNWYSVWKTC 60
Cdd:pfam00646   1 LLDLPDDLLLEILSRL-DPKDLLRLSLVSKRWRSLVDSL 38
 
Name Accession Description Interval E-value
DUF295 pfam03478
Protein of unknown function (DUF295); This domain is found in plant proteins of unknown ...
311-370 3.36e-07

Protein of unknown function (DUF295); This domain is found in plant proteins of unknown function. It can be found in association with F-box domain pfam00646.


Pssm-ID: 460939 [Multi-domain]  Cd Length: 57  Bit Score: 46.82  E-value: 3.36e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15224404   311 ERVYCIGDEMLIFGRGVT-ALALEDLDdGIKSNSIYFVGEDvwpDHQEHEHRVSNCGFFDI 370
Cdd:pfam03478   1 VEVKSLGDRALFLGRNCSlSVSASDFP-GLKGNCIYFLTDD---DDEVYKDEGRDIGVYDL 57
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
22-60 3.37e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 35.21  E-value: 3.37e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15224404    22 WSKLCPDVLRKIYETLrSPVDSHRAKIVCSNWYSVWKTC 60
Cdd:pfam00646   1 LLDLPDDLLLEILSRL-DPKDLLRLSLVSKRWRSLVDSL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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