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Conserved domains on  [gi|30699285|ref|NP_177900|]
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forkhead box protein, putative (DUF1644) [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF1644 super family cl20347
Protein of unknown function (DUF1644); This family consists of sequences found in a number of ...
 30-153 8.66e-76

Protein of unknown function (DUF1644); This family consists of sequences found in a number of hypothetical plant proteins of unknown function. The region of interest contains nine highly conserved cysteine residues and is approximately 160 amino acids in length, and is probably a zinc-binding domain.


The actual alignment was detected with superfamily member pfam07800:

Pssm-ID: 462269  Cd Length: 164  Bit Score: 227.46  E-value: 8.66e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30699285    30 TCPVCLESPHNAVLLLCSSYHKGCRPYMCATSSRFANCLDQYRKSYGN------------------------ENSGQPEL 85
Cdd:pfam07800   4 TCPICMEHPHNAVLLLCSSHDKGCRPYMCDTSYRHSNCLDRFKKAYGKsssstsqssssastnnsssnvvssSKEESSEL 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30699285    86 LCPLCRGQVKGWTVVKDARMHFNSKRRTCMQDNCSFLGNFRKLKKHMKEKHPHACPRAIDPALETKWK 153
Cdd:pfam07800  84 KCPLCRGQVKGWTVVEEARKYLNAKKRSCSEESCSFSGNYKELRKHARLEHPLARPSEVDPSRQRDWR 151
 
Name Accession Description Interval E-value
DUF1644 pfam07800
Protein of unknown function (DUF1644); This family consists of sequences found in a number of ...
 30-153 8.66e-76

Protein of unknown function (DUF1644); This family consists of sequences found in a number of hypothetical plant proteins of unknown function. The region of interest contains nine highly conserved cysteine residues and is approximately 160 amino acids in length, and is probably a zinc-binding domain.


Pssm-ID: 462269  Cd Length: 164  Bit Score: 227.46  E-value: 8.66e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30699285    30 TCPVCLESPHNAVLLLCSSYHKGCRPYMCATSSRFANCLDQYRKSYGN------------------------ENSGQPEL 85
Cdd:pfam07800   4 TCPICMEHPHNAVLLLCSSHDKGCRPYMCDTSYRHSNCLDRFKKAYGKsssstsqssssastnnsssnvvssSKEESSEL 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30699285    86 LCPLCRGQVKGWTVVKDARMHFNSKRRTCMQDNCSFLGNFRKLKKHMKEKHPHACPRAIDPALETKWK 153
Cdd:pfam07800  84 KCPLCRGQVKGWTVVEEARKYLNAKKRSCSEESCSFSGNYKELRKHARLEHPLARPSEVDPSRQRDWR 151
RING-HC_HLTF cd16509
RING finger, HC subclass, found in helicase-like transcription factor (HLTF) and similar ...
 31-95 1.41e-03

RING finger, HC subclass, found in helicase-like transcription factor (HLTF) and similar proteins; HLTF, also known as DNA-binding protein/plasminogen activator inhibitor 1 regulator, HIP116, RING finger protein 80, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3, or sucrose nonfermenting protein 2-like 3, is a yeast RAD5 homolog found in mammals. It has both E3 ubiquitin ligase and DNA helicase activities, and plays a pivotal role in the template-switching pathway of DNA damage tolerance. It is involved in Lys-63-linked poly-ubiquitination of proliferating cell nuclear antigen (PCNA) at Lys-164 and in the regulation of DNA damage tolerance. It shows double-stranded DNA translocase activity with 3'-5' polarity, thereby facilitating regression of the replication fork. HLTF contains an N-terminal HIRAN (HIP116 and RAD5 N-terminal) domain, a SWI/SNF helicase domain that is divided into N- and C-terminal parts by an insertion of a C3HC4-type RING-HC finger involved in the poly-ubiquitination of PCNA.


Pssm-ID: 438172 [Multi-domain]  Cd Length: 53  Bit Score: 36.13  E-value: 1.41e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30699285  31 CPVCLESPHNAVLLLCSsyHKGCRPYMCATSSRFANCldqyrksygnensgqpellCPLCRGQVK 95
Cdd:cd16509   6 CAICLDSLTNPVITPCA--HVFCRRCICEVIQREKAK-------------------CPMCRAPLS 49
 
Name Accession Description Interval E-value
DUF1644 pfam07800
Protein of unknown function (DUF1644); This family consists of sequences found in a number of ...
 30-153 8.66e-76

Protein of unknown function (DUF1644); This family consists of sequences found in a number of hypothetical plant proteins of unknown function. The region of interest contains nine highly conserved cysteine residues and is approximately 160 amino acids in length, and is probably a zinc-binding domain.


Pssm-ID: 462269  Cd Length: 164  Bit Score: 227.46  E-value: 8.66e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30699285    30 TCPVCLESPHNAVLLLCSSYHKGCRPYMCATSSRFANCLDQYRKSYGN------------------------ENSGQPEL 85
Cdd:pfam07800   4 TCPICMEHPHNAVLLLCSSHDKGCRPYMCDTSYRHSNCLDRFKKAYGKsssstsqssssastnnsssnvvssSKEESSEL 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30699285    86 LCPLCRGQVKGWTVVKDARMHFNSKRRTCMQDNCSFLGNFRKLKKHMKEKHPHACPRAIDPALETKWK 153
Cdd:pfam07800  84 KCPLCRGQVKGWTVVEEARKYLNAKKRSCSEESCSFSGNYKELRKHARLEHPLARPSEVDPSRQRDWR 151
RING-HC_HLTF cd16509
RING finger, HC subclass, found in helicase-like transcription factor (HLTF) and similar ...
 31-95 1.41e-03

RING finger, HC subclass, found in helicase-like transcription factor (HLTF) and similar proteins; HLTF, also known as DNA-binding protein/plasminogen activator inhibitor 1 regulator, HIP116, RING finger protein 80, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3, or sucrose nonfermenting protein 2-like 3, is a yeast RAD5 homolog found in mammals. It has both E3 ubiquitin ligase and DNA helicase activities, and plays a pivotal role in the template-switching pathway of DNA damage tolerance. It is involved in Lys-63-linked poly-ubiquitination of proliferating cell nuclear antigen (PCNA) at Lys-164 and in the regulation of DNA damage tolerance. It shows double-stranded DNA translocase activity with 3'-5' polarity, thereby facilitating regression of the replication fork. HLTF contains an N-terminal HIRAN (HIP116 and RAD5 N-terminal) domain, a SWI/SNF helicase domain that is divided into N- and C-terminal parts by an insertion of a C3HC4-type RING-HC finger involved in the poly-ubiquitination of PCNA.


Pssm-ID: 438172 [Multi-domain]  Cd Length: 53  Bit Score: 36.13  E-value: 1.41e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30699285  31 CPVCLESPHNAVLLLCSsyHKGCRPYMCATSSRFANCldqyrksygnensgqpellCPLCRGQVK 95
Cdd:cd16509   6 CAICLDSLTNPVITPCA--HVFCRRCICEVIQREKAK-------------------CPMCRAPLS 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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