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Conserved domains on  [gi|15223771|ref|NP_177815|]
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Duplicated homeodomain-like superfamily protein [Arabidopsis thaliana]

Protein Classification

trihelix transcription factor( domain architecture ID 10187508)

trihelix transcription factor such as Arabidopsis thaliana GT-1, which binds the GT cis-element of rbcS-3A, a light-induced gene, as a dimer. GT-1 is a trans-activator and acts in the stabilization of components of the transcription pre-initiation complex comprised of TFIIA-TBP-TATA. The isolated GT-1 DNA-binding domain is sufficient to bind DNA. This region closely resembles the myb domain, but with longer helices.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT1 cd12203
GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription ...
 396-461 4.21e-26

GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription factors. GT-1 binds the GT cis-element of rbcS-3A, a light-induced gene, as a dimer. Arabidopsis GT-1 is a trans-activator and acts in the stabilization of components of the transcription pre-initiation complex comprised of TFIIA-TBP-TATA. The isolated GT-1 DNA-binding domain is sufficient to bind DNA. This region closely resembles the myb domain, but with longer helices. It has been proposed that GT-1 may respond to light signals via calcium-dependent phosphorylation to create a light-modulated molecular switch. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


:

Pssm-ID: 213402  Cd Length: 66  Bit Score: 101.20  E-value: 4.21e-26
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15223771 396 SRWPKTEVEALIRIRKNLEANYQENGTKGPLWEEISAGMRRLGYNRSAKRCKEKWENINKYFKKVK 461
Cdd:cd12203   1 KRWPREETLSLIRLRREMESRFQETKSKKALWEEIAAKMRELGYNRSAKQCKEKWENLNKYYKKVK 66
GT1 cd12203
GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription ...
 40-105 1.28e-24

GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription factors. GT-1 binds the GT cis-element of rbcS-3A, a light-induced gene, as a dimer. Arabidopsis GT-1 is a trans-activator and acts in the stabilization of components of the transcription pre-initiation complex comprised of TFIIA-TBP-TATA. The isolated GT-1 DNA-binding domain is sufficient to bind DNA. This region closely resembles the myb domain, but with longer helices. It has been proposed that GT-1 may respond to light signals via calcium-dependent phosphorylation to create a light-modulated molecular switch. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


:

Pssm-ID: 213402  Cd Length: 66  Bit Score: 96.97  E-value: 1.28e-24
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15223771  40 NRWPRPETLALLRIRSEMDKAFRDSTLKAPLWEEISRKMMELGYKRSSKKCKEKFENVYKYHKRTK 105
Cdd:cd12203   1 KRWPREETLSLIRLRREMESRFQETKSKKALWEEIAAKMRELGYNRSAKQCKEKWENLNKYYKKVK 66
 
Name Accession Description Interval E-value
GT1 cd12203
GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription ...
 396-461 4.21e-26

GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription factors. GT-1 binds the GT cis-element of rbcS-3A, a light-induced gene, as a dimer. Arabidopsis GT-1 is a trans-activator and acts in the stabilization of components of the transcription pre-initiation complex comprised of TFIIA-TBP-TATA. The isolated GT-1 DNA-binding domain is sufficient to bind DNA. This region closely resembles the myb domain, but with longer helices. It has been proposed that GT-1 may respond to light signals via calcium-dependent phosphorylation to create a light-modulated molecular switch. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213402  Cd Length: 66  Bit Score: 101.20  E-value: 4.21e-26
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15223771 396 SRWPKTEVEALIRIRKNLEANYQENGTKGPLWEEISAGMRRLGYNRSAKRCKEKWENINKYFKKVK 461
Cdd:cd12203   1 KRWPREETLSLIRLRREMESRFQETKSKKALWEEIAAKMRELGYNRSAKQCKEKWENLNKYYKKVK 66
GT1 cd12203
GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription ...
 40-105 1.28e-24

GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription factors. GT-1 binds the GT cis-element of rbcS-3A, a light-induced gene, as a dimer. Arabidopsis GT-1 is a trans-activator and acts in the stabilization of components of the transcription pre-initiation complex comprised of TFIIA-TBP-TATA. The isolated GT-1 DNA-binding domain is sufficient to bind DNA. This region closely resembles the myb domain, but with longer helices. It has been proposed that GT-1 may respond to light signals via calcium-dependent phosphorylation to create a light-modulated molecular switch. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213402  Cd Length: 66  Bit Score: 96.97  E-value: 1.28e-24
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15223771  40 NRWPRPETLALLRIRSEMDKAFRDSTLKAPLWEEISRKMMELGYKRSSKKCKEKFENVYKYHKRTK 105
Cdd:cd12203   1 KRWPREETLSLIRLRREMESRFQETKSKKALWEEIAAKMRELGYNRSAKQCKEKWENLNKYYKKVK 66
Myb_DNA-bind_4 pfam13837
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb ...
 395-479 3.80e-23

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 463994  Cd Length: 84  Bit Score: 93.48  E-value: 3.80e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223771   395 SSRWPKTEVEALIRIRKN-LEANYQENGTKGP-LWEEISAGMRRLGYNRSAKRCKEKWENINKYFKKVKESNKKRPldsK 472
Cdd:pfam13837   1 RNKWTEEETLALIEIWGErLELRFQESKKRNKkLWEEIAEKMAELGYNRSPEQCKEKWENLKKKYRKEKEGNNGSG---S 77


                  ....*..
gi 15223771   473 TCPYFHQ 479
Cdd:pfam13837  78 SWPFFEE 84
Myb_DNA-bind_4 pfam13837
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb ...
 39-122 3.78e-21

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 463994  Cd Length: 84  Bit Score: 87.71  E-value: 3.78e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223771    39 GNRWPRPETLALLRIRSE-MDKAFRDSTLKAP-LWEEISRKMMELGYKRSSKKCKEKFENVYKYHKRTKEGRTGKseGKT 116
Cdd:pfam13837   1 RNKWTEEETLALIEIWGErLELRFQESKKRNKkLWEEIAEKMAELGYNRSPEQCKEKWENLKKKYRKEKEGNNGS--GSS 78


                  ....*.
gi 15223771   117 YRFFEE 122
Cdd:pfam13837  79 WPFFEE 84
MADF smart00595
subfamily of SANT domain;
58-124 7.88e-04

subfamily of SANT domain;


Pssm-ID: 214738  Cd Length: 89  Bit Score: 38.88  E-value: 7.88e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15223771     58 DKAFRDSTLKAPLWEEISRKMmelgyKRSSKKCKEKFENV-YKYH---KRTKEGRTGKSEGKTYRFFEELE 124
Cdd:smart00595  17 HPDYRNKEEKRKAWEEIAEEL-----GLSVEECKKRWKNLrDRYRrelKRLQNGKSGGGKKSKWEYFDRLS 82
 
Name Accession Description Interval E-value
GT1 cd12203
GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription ...
 396-461 4.21e-26

GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription factors. GT-1 binds the GT cis-element of rbcS-3A, a light-induced gene, as a dimer. Arabidopsis GT-1 is a trans-activator and acts in the stabilization of components of the transcription pre-initiation complex comprised of TFIIA-TBP-TATA. The isolated GT-1 DNA-binding domain is sufficient to bind DNA. This region closely resembles the myb domain, but with longer helices. It has been proposed that GT-1 may respond to light signals via calcium-dependent phosphorylation to create a light-modulated molecular switch. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213402  Cd Length: 66  Bit Score: 101.20  E-value: 4.21e-26
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15223771 396 SRWPKTEVEALIRIRKNLEANYQENGTKGPLWEEISAGMRRLGYNRSAKRCKEKWENINKYFKKVK 461
Cdd:cd12203   1 KRWPREETLSLIRLRREMESRFQETKSKKALWEEIAAKMRELGYNRSAKQCKEKWENLNKYYKKVK 66
GT1 cd12203
GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription ...
 40-105 1.28e-24

GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription factors. GT-1 binds the GT cis-element of rbcS-3A, a light-induced gene, as a dimer. Arabidopsis GT-1 is a trans-activator and acts in the stabilization of components of the transcription pre-initiation complex comprised of TFIIA-TBP-TATA. The isolated GT-1 DNA-binding domain is sufficient to bind DNA. This region closely resembles the myb domain, but with longer helices. It has been proposed that GT-1 may respond to light signals via calcium-dependent phosphorylation to create a light-modulated molecular switch. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213402  Cd Length: 66  Bit Score: 96.97  E-value: 1.28e-24
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15223771  40 NRWPRPETLALLRIRSEMDKAFRDSTLKAPLWEEISRKMMELGYKRSSKKCKEKFENVYKYHKRTK 105
Cdd:cd12203   1 KRWPREETLSLIRLRREMESRFQETKSKKALWEEIAAKMRELGYNRSAKQCKEKWENLNKYYKKVK 66
Myb_DNA-bind_4 pfam13837
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb ...
 395-479 3.80e-23

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 463994  Cd Length: 84  Bit Score: 93.48  E-value: 3.80e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223771   395 SSRWPKTEVEALIRIRKN-LEANYQENGTKGP-LWEEISAGMRRLGYNRSAKRCKEKWENINKYFKKVKESNKKRPldsK 472
Cdd:pfam13837   1 RNKWTEEETLALIEIWGErLELRFQESKKRNKkLWEEIAEKMAELGYNRSPEQCKEKWENLKKKYRKEKEGNNGSG---S 77


                  ....*..
gi 15223771   473 TCPYFHQ 479
Cdd:pfam13837  78 SWPFFEE 84
Myb_DNA-bind_4 pfam13837
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb ...
 39-122 3.78e-21

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 463994  Cd Length: 84  Bit Score: 87.71  E-value: 3.78e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223771    39 GNRWPRPETLALLRIRSE-MDKAFRDSTLKAP-LWEEISRKMMELGYKRSSKKCKEKFENVYKYHKRTKEGRTGKseGKT 116
Cdd:pfam13837   1 RNKWTEEETLALIEIWGErLELRFQESKKRNKkLWEEIAEKMAELGYNRSPEQCKEKWENLKKKYRKEKEGNNGS--GSS 78


                  ....*.
gi 15223771   117 YRFFEE 122
Cdd:pfam13837  79 WPFFEE 84
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 58-124 4.77e-06

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 44.97  E-value: 4.77e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15223771    58 DKAFRDSTLKAPLWEEISRkmmELGYKRSSKKCKEKFEN-VYKYHK--RTKEGRTGKSEGKTYRFFEELE 124
Cdd:pfam10545  16 HPDYRNRDARERAWEEIAE---ELGSDVPVEDCKKRWKNlRDQYRRelRRKRTNSGELYKSRWYYYEELS 82
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 416-483 3.21e-04

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 39.58  E-value: 3.21e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15223771   416 NYQENGTKGPLWEEISagmRRLGYNRSAKRCKEKWENI----NKYFKKVKESNKKRPldSKTCPYFHQLEAL 483
Cdd:pfam10545  18 DYRNRDARERAWEEIA---EELGSDVPVEDCKKRWKNLrdqyRRELRRKRTNSGELY--KSRWYYYEELSFL 84
MADF smart00595
subfamily of SANT domain;
58-124 7.88e-04

subfamily of SANT domain;


Pssm-ID: 214738  Cd Length: 89  Bit Score: 38.88  E-value: 7.88e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15223771     58 DKAFRDSTLKAPLWEEISRKMmelgyKRSSKKCKEKFENV-YKYH---KRTKEGRTGKSEGKTYRFFEELE 124
Cdd:smart00595  17 HPDYRNKEEKRKAWEEIAEEL-----GLSVEECKKRWKNLrDRYRrelKRLQNGKSGGGKKSKWEYFDRLS 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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