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Conserved domains on  [gi|30698020|ref|NP_177185|]
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NHL domain-containing protein [Arabidopsis thaliana]

Protein Classification

NHL repeat-containing protein( domain architecture ID 110303)

NHL (NCL-1, HT2A and LIN-41) repeat-containing protein may have a catalytic activity or interact with other proteins; NHL is a six-bladed beta-propeller

CATH:  2.40.10.500
Gene Ontology:  GO:0005515
PubMed:  9868369|17979191

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
85-226 4.54e-25

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14953:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 323  Bit Score: 105.69  E-value: 4.54e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  85 PYSIEVLPNGELLILDSENSNIYKISSSlslysrpRLVT---GSPE-GYPGhvDGRLRDAKLNHPKGLTVDDRGNIYVAD 160
Cdd:cd14953  79 PSGVAVDAAGNLYVADTGNHRIRKITPD-------GVVStlaGTGTaGFSD--DGGATAAQFNYPTGVAVDAAGNLYVAD 149
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30698020 161 TVNNAIRKISEGG-VTTIAGgkTVRNGGHVDGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREI 226
Cdd:cd14953 150 TGNHRIRKITPDGvVTTVAG--TGGAGYAGDGPATAAQFNNPTGVA-VDAAGNLYVADRGNHRIRKI 213
 
Name Accession Description Interval E-value
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
85-226 4.54e-25

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 105.69  E-value: 4.54e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  85 PYSIEVLPNGELLILDSENSNIYKISSSlslysrpRLVT---GSPE-GYPGhvDGRLRDAKLNHPKGLTVDDRGNIYVAD 160
Cdd:cd14953  79 PSGVAVDAAGNLYVADTGNHRIRKITPD-------GVVStlaGTGTaGFSD--DGGATAAQFNYPTGVAVDAAGNLYVAD 149
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30698020 161 TVNNAIRKISEGG-VTTIAGgkTVRNGGHVDGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREI 226
Cdd:cd14953 150 TGNHRIRKITPDGvVTTVAG--TGGAGYAGDGPATAAQFNNPTGVA-VDAAGNLYVADRGNHRIRKI 213
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
82-191 1.89e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 58.49  E-value: 1.89e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  82 GIEPYSIEVLPNGELLILDSENSNIYKISsslslysrprLVTGSPEGYPghvdgrlrDAKLNHPKGLTVDDRGNIYVADT 161
Cdd:COG4257  16 GSGPRDVAVDPDGAVWFTDQGGGRIGRLD----------PATGEFTEYP--------LGGGSGPHGIAVDPDGNLWFTDN 77
                        90       100       110
                ....*....|....*....|....*....|....
gi 30698020 162 VNNAIRKIS--EGGVTTIAGGKTVRN--GGHVDG 191
Cdd:COG4257  78 GNNRIGRIDpkTGEITTFALPGGGSNphGIAFDP 111
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
84-232 1.92e-09

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 60.25  E-value: 1.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020    84 EPYSIEVLPN-GELLILDSENSNIykisSSLSLYSR-PRLVTGSPEGYP------GHVDGRLRDAKLNHPKGLTVDDRGN 155
Cdd:PLN02919  741 QPSGISLSPDlKELYIADSESSSI----RALDLKTGgSRLLAGGDPTFSdnlfkfGDHDGVGSEVLLQHPLGVLCAKDGQ 816
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020   156 IYVADTVNNAIRKI--SEGGVTTIAG-GKtvrnGGHVDGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREIQLHFDD 232
Cdd:PLN02919  817 IYVADSYNHKIKKLdpATKRVTTLAGtGK----AGFKDGKALKAQLSEPAGLA-LGENGRLFVADTNNSLIRYLDLNKGE 891
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
142-168 6.90e-04

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 37.00  E-value: 6.90e-04
                          10        20
                  ....*....|....*....|....*..
gi 30698020   142 LNHPKGLTVDDRGNIYVADTVNNAIRK 168
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQV 27
 
Name Accession Description Interval E-value
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
85-226 4.54e-25

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 105.69  E-value: 4.54e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  85 PYSIEVLPNGELLILDSENSNIYKISSSlslysrpRLVT---GSPE-GYPGhvDGRLRDAKLNHPKGLTVDDRGNIYVAD 160
Cdd:cd14953  79 PSGVAVDAAGNLYVADTGNHRIRKITPD-------GVVStlaGTGTaGFSD--DGGATAAQFNYPTGVAVDAAGNLYVAD 149
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30698020 161 TVNNAIRKISEGG-VTTIAGgkTVRNGGHVDGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREI 226
Cdd:cd14953 150 TGNHRIRKITPDGvVTTVAG--TGGAGYAGDGPATAAQFNNPTGVA-VDAAGNLYVADRGNHRIRKI 213
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
85-226 2.60e-24

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 103.38  E-value: 2.60e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  85 PYSIEVLPNGELLILDSENSNIYKISSSLSlysrprlVT---GSPeGYPGHVDGRLRDAKLNHPKGLTVDDRGNIYVADT 161
Cdd:cd14953 189 PTGVAVDAAGNLYVADRGNHRIRKITPDGV-------VTtvaGTG-TAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADS 260
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30698020 162 VNNAIRKISEGG-VTTIAGGKTVRNGGhvDGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREI 226
Cdd:cd14953 261 GNHRIRKITPAGvVTTVAGGGAGFSGD--GGPATSAQFNNPTGVA-VDAAGNLYVADTGNNRIRKI 323
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
85-256 2.99e-22

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 97.22  E-value: 2.99e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  85 PYSIEVLPNGELLILDSENSNIYKISSSLSlysrprlVT---GSPeGYPGHVDGRLRDAKLNHPKGLTVDDRGNIYVADT 161
Cdd:cd14953 134 PTGVAVDAAGNLYVADTGNHRIRKITPDGV-------VTtvaGTG-GAGYAGDGPATAAQFNNPTGVAVDAAGNLYVADR 205
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 162 VNNAIRKISEGG-VTTIAGGKTVrnGGHVDGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREIQlhfddcayqygsg 240
Cdd:cd14953 206 GNHRIRKITPDGvVTTVAGTGTA--GFSGDGGATAAQLNNPTGVA-VDAAGNLYVADSGNHRIRKIT------------- 269
                       170
                ....*....|....*.
gi 30698020 241 fPLGIAVLVAAGFFGY 256
Cdd:cd14953 270 -PAGVVTTVAGGGAGF 284
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
128-226 1.08e-20

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 92.98  E-value: 1.08e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 128 GYPGHVDGRLRDAKLNHPKGLTVDDRGNIYVADTVNNAIRKIS-EGGVTTIAGGKTvrnGGHVDGPSEDAKFSNDFDVVy 206
Cdd:cd14953   8 GTAGFSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKITpDGVVTTVAGTGT---AGFADGGGAAAQFNTPSGVA- 83
                        90       100
                ....*....|....*....|
gi 30698020 207 VGSSCSLLVIDRGNKAIREI 226
Cdd:cd14953  84 VDAAGNLYVADTGNHRIRKI 103
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
85-226 1.10e-20

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 92.98  E-value: 1.10e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  85 PYSIEVLPNGELLILDSENSNIYKISSSlslysrpRLVT---GSpeGYPGHVDGRLRDAKLNHPKGLTVDDRGNIYVADT 161
Cdd:cd14953  25 PSGVAVDAAGNLYVADRGNHRIRKITPD-------GVVTtvaGT--GTAGFADGGGAAAQFNTPSGVAVDAAGNLYVADT 95
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30698020 162 VNNAIRKISEGG-VTTIAGGKTVRNGGhvDGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREI 226
Cdd:cd14953  96 GNHRIRKITPDGvVSTLAGTGTAGFSD--DGGATAAQFNYPTGVA-VDAAGNLYVADTGNHRIRKI 158
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
77-247 2.17e-15

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 76.20  E-value: 2.17e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  77 DGSKLG--IEPYSIEVLPNGELLILDSENSNIYKISSSlslySRPRLVTGSPEGYPGhvdgrlrdaKLNHPKGLTVDDRG 154
Cdd:cd05819  47 FGSGDGqfNEPAGVAVDSDGNLYVADTGNHRIQKFDPD----GNFLASFGGSGDGDG---------EFNGPRGIAVDSSG 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 155 NIYVADTVNNAIRKI-SEGGVTTIAGGKTvrngghvdgpSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIR------EIQ 227
Cdd:cd05819 114 NIYVADTGNHRIQKFdPDGEFLTTFGSGG----------SGPGQFNGPTGVA-VDSDGNIYVADTGNHRIQvfdpdgNFL 182
                       170       180
                ....*....|....*....|..
gi 30698020 228 LHFDDcAYQYGSGF--PLGIAV 247
Cdd:cd05819 183 TTFGS-TGTGPGQFnyPTGIAV 203
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
84-226 2.75e-15

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 75.82  E-value: 2.75e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  84 EPYSIEVLPNGELLILDSENSNIYKISSSlslySRPRLVTGSPEGYPGhvdgrlrdaKLNHPKGLTVDDRGNIYVADTVN 163
Cdd:cd05819 150 GPTGVAVDSDGNIYVADTGNHRIQVFDPD----GNFLTTFGSTGTGPG---------QFNYPTGIAVDSDGNIYVADSGN 216
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30698020 164 NAIRKISEGGVTTIAGGKTVRNGGHVDGPSEdakfsndfdvVYVGSSCSLLVIDRGNKAIREI 226
Cdd:cd05819 217 NRVQVFDPDGAGFGGNGNFLGSDGQFNRPSG----------LAVDSDGNLYVADTGNNRIQVF 269
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
92-228 5.93e-15

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 76.08  E-value: 5.93e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  92 PNGELLILDSENSNIYKIS----SSLSLYSRPRLVTGSPEGypGHVDGRLRDAKLNHPKGLTVDDRGNIYVADTVNNAIR 167
Cdd:cd14951 143 GWGELFVADSESSAIRAVSlkdgGVKTLVGGTRVGTGLFDF--GDRDGPGAEALLQHPLGVAALPDGSVYVADTYNHKIK 220
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30698020 168 KI--SEGGVTTIAGGKTVrngGHVDGPsedAKFSNDFDVVYVGSScSLLVIDRGNKAIREIQL 228
Cdd:cd14951 221 RVdpATGEVSTLAGTGKA---GYKDLE---AQFSEPSGLVVDGDG-RLYVADTNNHRIRRLDL 276
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
124-206 6.38e-15

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 75.69  E-value: 6.38e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 124 GSPEgyPGHVDGRLRDAKLNHPKGLTVDDRGNIYVADTVNNAIRKI--SEGGVTTIAG-GK--TVRNGGhvdGPSEDAKF 198
Cdd:cd14951   2 GSGE--RGLKDGSFAEASFNEPQGLALLPGNILYVADTENHALRKIdlETGTVTTLAGtGEqgRDGEGG---GPGREQPL 76

                ....*...
gi 30698020 199 SNDFDVVY 206
Cdd:cd14951  77 SSPWDVAW 84
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
85-247 3.71e-14

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 72.74  E-value: 3.71e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  85 PYSIEVLPNGELLILDSENSNIYKIssslslysrprlvtgSPEGYPGHVDGRL--RDAKLNHPKGLTVDDRGNIYVADTV 162
Cdd:cd05819  10 PQGIAVDSSGNIYVADTGNNRIQVF---------------DPDGNFITSFGSFgsGDGQFNEPAGVAVDSDGNLYVADTG 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 163 NNAIRKISEGGVTTIAGGKTVRNGGHVDGPSedakfsndfdVVYVGSSCSLLVIDRGNKAIREiqlhFDD---CAYQYGS 239
Cdd:cd05819  75 NHRIQKFDPDGNFLASFGGSGDGDGEFNGPR----------GIAVDSSGNIYVADTGNHRIQK----FDPdgeFLTTFGS 140
                       170
                ....*....|....*.
gi 30698020 240 G--------FPLGIAV 247
Cdd:cd05819 141 GgsgpgqfnGPTGVAV 156
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
70-247 1.58e-12

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 68.06  E-value: 1.58e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  70 YSVETVFDGSKLGIEPYSIEVLPNGELLILDSENSNIyKISSSLSLYSRPRLVTGSPEGYpghvdgrlrdakLNHPKGLT 149
Cdd:cd14957  52 YSIGSGGTGSGQFNSPYGIAVDSNGNIYVADTDNNRI-QVFNSSGVYQYSIGTGGSGDGQ------------FNGPYGIA 118
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 150 VDDRGNIYVADTVNNAIRKISEGGVTTIAGGKTVRNGGHVDGPSEdakfsndfdvVYVGSSCSLLVIDRGNKAireIQLH 229
Cdd:cd14957 119 VDSNGNIYVADTGNHRIQVFTSSGTFSYSIGSGGTGPGQFNGPQG----------IAVDSDGNIYVADTGNHR---IQVF 185
                       170       180
                ....*....|....*....|....*...
gi 30698020 230 FDDCAYQY---GSGF-------PLGIAV 247
Cdd:cd14957 186 TSSGTFQYtfgSSGSgpgqfsdPYGIAV 213
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
82-191 1.89e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 58.49  E-value: 1.89e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  82 GIEPYSIEVLPNGELLILDSENSNIYKISsslslysrprLVTGSPEGYPghvdgrlrDAKLNHPKGLTVDDRGNIYVADT 161
Cdd:COG4257  16 GSGPRDVAVDPDGAVWFTDQGGGRIGRLD----------PATGEFTEYP--------LGGGSGPHGIAVDPDGNLWFTDN 77
                        90       100       110
                ....*....|....*....|....*....|....
gi 30698020 162 VNNAIRKIS--EGGVTTIAGGKTVRN--GGHVDG 191
Cdd:COG4257  78 GNNRIGRIDpkTGEITTFALPGGGSNphGIAFDP 111
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
84-232 1.92e-09

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 60.25  E-value: 1.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020    84 EPYSIEVLPN-GELLILDSENSNIykisSSLSLYSR-PRLVTGSPEGYP------GHVDGRLRDAKLNHPKGLTVDDRGN 155
Cdd:PLN02919  741 QPSGISLSPDlKELYIADSESSSI----RALDLKTGgSRLLAGGDPTFSdnlfkfGDHDGVGSEVLLQHPLGVLCAKDGQ 816
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020   156 IYVADTVNNAIRKI--SEGGVTTIAG-GKtvrnGGHVDGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREIQLHFDD 232
Cdd:PLN02919  817 IYVADSYNHKIKKLdpATKRVTTLAGtGK----AGFKDGKALKAQLSEPAGLA-LGENGRLFVADTNNSLIRYLDLNKGE 891
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
139-247 3.07e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 57.71  E-value: 3.07e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 139 DAKLNHPKGLTVDDRGNIYVADTVNNAIRKISEGGVTTIAGGKTVRNGGHVDGPSEdakfsndfdvVYVGSSCSLLVIDR 218
Cdd:cd05819   4 PGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPDGNFITSFGSFGSGDGQFNEPAG----------VAVDSDGNLYVADT 73
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 30698020 219 GNKAIREI--QLHFDDCAYQYGSGF-----PLGIAV 247
Cdd:cd05819  74 GNHRIQKFdpDGNFLASFGGSGDGDgefngPRGIAV 109
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
85-178 1.92e-08

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 55.41  E-value: 1.92e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  85 PYSIEVLPNGELLILDSENSNIYKISSSlslysrprlvTGSPEGYPGHvdgrlrdAKLNHPKGLTVDDRGNIYVADTVNN 164
Cdd:COG4257 147 PYGIAVDPDGNLWVTDFGANAIGRIDPD----------TGTLTEYALP-------TPGAGPRGLAVDPDGNLWVADTGSG 209
                        90
                ....*....|....*.
gi 30698020 165 AIRKI--SEGGVTTIA 178
Cdd:COG4257 210 RIGRFdpKTGTVTEYP 225
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
136-226 4.23e-08

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 54.89  E-value: 4.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 136 RLRDAKLNH------PKGLTVDDRGNIYVADTVNNAIRKIS--EGGVTTIAGGktVRNG------GHVDGPSEDAKFSND 201
Cdd:cd14951 121 GNRNGPYPHeawfaqPSGLSLAGWGELFVADSESSAIRAVSlkDGGVKTLVGG--TRVGtglfdfGDRDGPGAEALLQHP 198
                        90       100
                ....*....|....*....|....*
gi 30698020 202 FDVVYVGSScSLLVIDRGNKAIREI 226
Cdd:cd14951 199 LGVAALPDG-SVYVADTYNHKIKRV 222
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
85-169 1.04e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 53.44  E-value: 1.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  85 PYSIEVLPNGELLILDSENSNIYKISSSlslySRPRLVTGSPegypGHVDGRLRDaklnhPKGLTVDDRGNIYVADTVNN 164
Cdd:cd14956 203 PYGIAIDPDGNVFVADFGNNRIQKFTAD----GTFLTSWGSP----GTGPGQFKN-----PWGVVVDADGTVYVADSNNN 269

                ....*
gi 30698020 165 AIRKI 169
Cdd:cd14956 270 RVQRF 274
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
85-223 5.18e-07

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 51.04  E-value: 5.18e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  85 PYSIEVLPNGELLILDSENSNIYKISSSLSLysrprlVT--GSPEGypghvdgrlRDAKLNHPKGLTVDDRGNIYVADTV 162
Cdd:cd14955 159 PTGIAVDSAGNVYVADTGNNRIQKFTSTGTF------LTkwGSEGS---------GDGQFNAPYGIAVDSAGNVYVADTG 223
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 30698020 163 NNAIRKISEGGVTTIAGGktvrNGGHVDGPsedakFSNDFDVVyVGSSCSLLVIDRGNKAI 223
Cdd:cd14955 224 NNRIQKFDSSGTFITKWG----SEGSGDGQ-----FNSPSGIA-VDSAGNVYVADSGNNRI 274
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
139-247 1.20e-06

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 50.27  E-value: 1.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 139 DAKLNHPKGLTVDDRGNIYVADTVNNAIRKISEGGVTTIAGGktvRNGghvdgpSEDAKFSNDFDVVyVGSSCSLLVIDR 218
Cdd:cd14955  12 DGQFNSPSGIAVDSAGNVYVADTGNNRIQKFDSTGTFLTKWG---SSG------SGDGQFYSPTGIA-VDSDGNVYVADT 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 30698020 219 GNKAIREiqlhFD-DCAYQ-----YGSG-----FPLGIAV 247
Cdd:cd14955  82 GNHRIQK----FDsTGTFLtkwgsSGSGdgqfnSPSGIAV 117
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
84-220 2.02e-06

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 49.47  E-value: 2.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  84 EPYSIEVLPNGELLILDSENSNIYKISSSLSLYSrprlVTGSpEGYPGHvdgrlrdaKLNHPKGLTVDDRGNIYVADTVN 163
Cdd:cd14954 166 SPRGVAVNPDGNIVVSDFNNHRLQVFDPDGQFLR----FFGS-EGSGNG--------QFKRPRGVAVDDEGNIIVADSGN 232
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 30698020 164 NAIRKISEGGVTTIAGGKTVRNGGHVDGPSEdakfsndfdvVYVGSSCSLLVIDRGN 220
Cdd:cd14954 233 HRVQVFSPDGEFLCSFGTEGNGEGQFDRPSG----------VAVTPDGRIVVVDRGN 279
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
74-169 2.90e-06

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 48.86  E-value: 2.90e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  74 TVFDGSKLGIEPYSIEVLPNGELLILDSENSNIYKISSSlslysrprlvTGSPEGYPGHVDGrlrdaklNHPKGLTVDDR 153
Cdd:COG4257 179 TEYALPTPGAGPRGLAVDPDGNLWVADTGSGRIGRFDPK----------TGTVTEYPLPGGG-------ARPYGVAVDGD 241
                        90
                ....*....|....*.
gi 30698020 154 GNIYVADTVNNAIRKI 169
Cdd:COG4257 242 GRVWFAESGANRIVRF 257
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
78-166 3.10e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 48.83  E-value: 3.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  78 GSKLG--IEPYSIEVLPNGELLILDSEN----------SNIYKISSS---LSLYSRPR-------------------LVT 123
Cdd:cd14963 141 GSEPGelSYPNGIAVDEDGNIYVADSGNgriqvfdkngKFIKELNGSpdgKSGFVNPRgiavdpdgnlyvvdnlshrVYV 220
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 30698020 124 GSPEGYPGHVDGR--LRDAKLNHPKGLTVDDRGNIYVADTVNNAI 166
Cdd:cd14963 221 FDEQGKELFTFGGrgKDDGQFNLPNGLFIDDDGRLYVTDRENNRV 265
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
77-212 3.33e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 48.82  E-value: 3.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  77 DGSKLGIEPYSIEVLPNGELLILDSENSNIYKisssLSLYSRPRLVTGSPEGYPGHVDGrlrdaklnhPKGLTVDDRGNI 156
Cdd:cd14956  54 DGPGQFGRPRGLAVDKDGWLYVADYWGDRIQV----FTLTGELQTIGGSSGSGPGQFNA---------PRGVAVDADGNL 120
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 30698020 157 YVADTVNNAIRKISEGGVTTIAGGKTVRNGGHVDGPsEDAKFSNDfDVVYVGSSCS 212
Cdd:cd14956 121 YVADFGNQRIQKFDPDGSFLRQWGGTGIEPGSFNYP-RGVAVDPD-GTLYVADTYN 174
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
85-247 4.11e-06

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 48.34  E-value: 4.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  85 PYSIEVLPNGELLILDSENSNIYKISSSLSLysrprlVT--GSPEGYPGHvdgrlrdakLNHPKGLTVDDRGNIYVADTV 162
Cdd:cd14955 112 PSGIAVDSAGNVYVTDSGNNRIQKFDSSGTF------ITkwGSFGSGDGQ---------FNSPTGIAVDSAGNVYVADTG 176
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 163 NNAIRKI-SEGGVTTIAGGktvrngghvdGPSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREiqlhFD-DCAYQ---- 236
Cdd:cd14955 177 NNRIQKFtSTGTFLTKWGS----------EGSGDGQFNAPYGIA-VDSAGNVYVADTGNNRIQK----FDsSGTFItkwg 241
                       170
                ....*....|....*..
gi 30698020 237 -YGSG-----FPLGIAV 247
Cdd:cd14955 242 sEGSGdgqfnSPSGIAV 258
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
83-170 1.26e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 46.80  E-value: 1.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  83 IEPYSIEVLPNGELLILDSENSNIYKISSSLSLysrprlvtGSPEGYPGHVDGrlrdaKLNHPKGLTVDDRGNIYVADTV 162
Cdd:cd14955 204 NAPYGIAVDSAGNVYVADTGNNRIQKFDSSGTF--------ITKWGSEGSGDG-----QFNSPSGIAVDSAGNVYVADSG 270

                ....*...
gi 30698020 163 NNAIRKIS 170
Cdd:cd14955 271 NNRIQKFA 278
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
142-247 2.42e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 45.66  E-value: 2.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 142 LNHPKGLTVDDRGNIYVADTVNNAIRKISEGgvttiAGGKTVRNGGHVDGPSedakfsndfdVVYVGSSCSLLVIDRGNK 221
Cdd:cd14952 135 LSNPDGVAVDGAGNVYVTDTGNNRVLKLAAG-----STTQTVLPFTGLNSPS----------GVAVDTAGNVYVTDHGNN 199
                        90       100       110
                ....*....|....*....|....*....|....
gi 30698020 222 AIRE--------IQLHFDdcayqyGSGFPLGIAV 247
Cdd:cd14952 200 RVLKlaagsttpTVLPFT------GLNGPLGVAV 227
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
84-210 6.73e-05

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 44.56  E-value: 6.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  84 EPYSIEVLPNGELLILDSENSNIYKISSSLSLYSRprlvTGSPEGYPGhvdgrlrdaKLNHPKGLTVDDRGNIYVADTVN 163
Cdd:cd14957 160 GPQGIAVDSDGNIYVADTGNHRIQVFTSSGTFQYT----FGSSGSGPG---------QFSDPYGIAVDSDGNIYVADTGN 226
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 30698020 164 NAIRKISEGGVTTIAGGKTVRNGGHVDGPSEDAKFSNDFdvVYVGSS 210
Cdd:cd14957 227 HRIQVFTSSGAYQYSIGTSGSGNGQFNYPYGIAVDNDGK--IYVADS 271
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
84-248 8.29e-05

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 44.57  E-value: 8.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  84 EPYSIEVLPNGELLILDSENSNIYkissslslysrpRLVTGSPEGYPGHvdGRLRDAKLNHPKGLTVDDRGNIYVADTVN 163
Cdd:cd14961 100 LPWGVAVNPSGEILVTDSEAGKLF------------VLTVDFKLGILKK--GQKLCSQLCRPRFVAVSRLGAVAVTEHLF 165
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 164 NAIRKISEGGVTTIAGGKTVRNGGHVDGPSEDAKFSNDFDVVYVGSSCSLLVIDRGNKAIreIQLHFDD---CAYQ---Y 237
Cdd:cd14961 166 ANGTRSSSTRVKVFSSGGQLLGQIDSFGLNLVFPSLICASGVAFDSEGNVIVADTGSGAI--LCLGKPEgfpILKPivtQ 243
                       170
                ....*....|.
gi 30698020 238 GSGFPLGIAVL 248
Cdd:cd14961 244 GLSRPVGLAVT 254
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
84-247 1.28e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 43.72  E-value: 1.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  84 EPYSIEVLPNGELLILDSENSNIYKISSslslysrprlvTGSPE---GYPGHVDGrlrdaKLNHPKGLTVDDRGNIYVAD 160
Cdd:cd14955  64 SPTGIAVDSDGNVYVADTGNHRIQKFDS-----------TGTFLtkwGSSGSGDG-----QFNSPSGIAVDSAGNVYVTD 127
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 161 TVNNAIRKISEGGvTTIAggKTVRNGghvdgpSEDAKFSNDFDVVyVGSSCSLLVIDRGNKAIREiqlhFD-DCAYQ--- 236
Cdd:cd14955 128 SGNNRIQKFDSSG-TFIT--KWGSFG------SGDGQFNSPTGIA-VDSAGNVYVADTGNNRIQK----FTsTGTFLtkw 193
                       170
                ....*....|....*...
gi 30698020 237 --YGSG-----FPLGIAV 247
Cdd:cd14955 194 gsEGSGdgqfnAPYGIAV 211
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
142-247 2.02e-04

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 43.41  E-value: 2.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 142 LNHPKGLTVDDRGNIYVADTVNNAIRKISEGGVTTIAGGktvrNGGHVDGpsedaKFSNDFDvVYVGSSCSLLVIDRGNK 221
Cdd:cd14957  17 FNTPRGIAVDSAGNIYVADTGNNRIQVFTSSGVYSYSIG----SGGTGSG-----QFNSPYG-IAVDSNGNIYVADTDNN 86
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 30698020 222 airEIQLHFDDCAYQY--GSG--------FPLGIAV 247
Cdd:cd14957  87 ---RIQVFNSSGVYQYsiGTGgsgdgqfnGPYGIAV 119
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
85-181 6.36e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.51  E-value: 6.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  85 PYSIEVLPNGELLILDSENSNIYKISSS---LSLY--SRPRLVTGSPEG--------YPGHV----------DGRL---- 137
Cdd:cd14963  58 PYGIAVDSDGNIYVADLYNGRIQVFDPDgkfLKYFpeKKDRVKLISPAGlaiddgklYVSDVkkhkvivfdlEGKLllef 137
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 30698020 138 -----RDAKLNHPKGLTVDDRGNIYVADTVNNAIRKISEGG--VTTIAGGK 181
Cdd:cd14963 138 gkpgsEPGELSYPNGIAVDEDGNIYVADSGNGRIQVFDKNGkfIKELNGSP 188
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
142-168 6.90e-04

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 37.00  E-value: 6.90e-04
                          10        20
                  ....*....|....*....|....*..
gi 30698020   142 LNHPKGLTVDDRGNIYVADTVNNAIRK 168
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQV 27
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
138-247 7.88e-04

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 41.38  E-value: 7.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 138 RDAKLNHPKGLTVDDRGNIYVADTVNNAIRKISEGGVTTIA-GGKTVRNGghvdgpsedaKFSNDFDVVyVGSSCSLLVI 216
Cdd:cd14954  66 RDGQFDRPAGVAVNSRGRIIVADKDNHRIQVFDLNGRFLLKfGERGTKNG----------QFNYPWGVA-VDSEGRIYVS 134
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 30698020 217 DRGNkaiREIQLHFDDCAY--QYGS--------GFPLGIAV 247
Cdd:cd14954 135 DTRN---HRVQVFDSDGQFirKFGFegagpgqlDSPRGVAV 172
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
142-172 1.21e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 40.65  E-value: 1.21e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 30698020 142 LNHPKGLTVDDRGNIYVADTVNNAIRKISEG 172
Cdd:cd14952  93 LNDPTGVAVDAAGNVYVADTGNNRVLKLAAG 123
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
142-220 1.48e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 40.34  E-value: 1.48e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30698020 142 LNHPKGLTVDDRGNIYVADTVNNAIRKISEGGVTTIAGGKTvrngghvdgPSEDAKFSNDFDVVyVGSSCSLLVIDRGN 220
Cdd:cd14956 200 FNYPYGIAIDPDGNVFVADFGNNRIQKFTADGTFLTSWGSP---------GTGPGQFKNPWGVV-VDADGTVYVADSNN 268
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
142-170 2.14e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 39.88  E-value: 2.14e-03
                        10        20
                ....*....|....*....|....*....
gi 30698020 142 LNHPKGLTVDDRGNIYVADTVNNAIRKIS 170
Cdd:cd14952 219 LNGPLGVAVDAAGNVYVADRGNDRVVKLP 247
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
138-247 3.28e-03

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 39.57  E-value: 3.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 138 RDAKLNHPKGLTVDDRGNIYVADTVNNAIRKISEGGvttiaggktvrNGGHVDGPSEDAKFSND--FDVVyVGSSCSLLV 215
Cdd:cd14961   6 WPGTLNNPTGVAVTPTGRVVVADDGNKRIQVFDSDG-----------NCLQQFGPKGDAGQDIRypLDVA-VTPDGHIVV 73
                        90       100       110
                ....*....|....*....|....*....|....*
gi 30698020 216 IDRGNKAIREIQlhFDDCAYQY-GSGF--PLGIAV 247
Cdd:cd14961  74 TDAGDRSVKVFS--FDGRLKLFvRKSFslPWGVAV 106
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
93-173 4.23e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 39.20  E-value: 4.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  93 NGELLILDSENSNIYKISSSlslySRPRLVTGSPEGYPGhvdgrlrdaKLNHPKGLTVDDRGNIYVADTVNNAIRKISEG 172
Cdd:cd14963  19 DGRIYVADTNNHRVQVFDYE----GKFKKSFGGPGTGPG---------EFKYPYGIAVDSDGNIYVADLYNGRIQVFDPD 85

                .
gi 30698020 173 G 173
Cdd:cd14963  86 G 86
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
94-228 5.26e-03

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 39.45  E-value: 5.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020    94 GELLILDSEnsniyKISSSLSLYSRPRLVTgSPEGYPGH-----VDGRLRDAKLNHPKgltvddrgnIYVADTVNNAIRK 168
Cdd:PLN02919  540 GEKKLLDST-----PLPLSLEKDNDPRLLT-SPLKFPGKlaidlLNNRLFISDSNHNR---------IVVTDLDGNFIVQ 604
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020   169 ISEGGvttiaggktvrNGGHVDGPSEDAKFSNDFDVVYVGSSCSLLVIDRGNKAIREIQL 228
Cdd:PLN02919  605 IGSTG-----------EEGLRDGSFEDATFNRPQGLAYNAKKNLLYVADTENHALREIDF 653
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
142-191 5.70e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 38.73  E-value: 5.70e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 30698020 142 LNHPKGLTVDDRGNIYVADTVNNAIRKISEG--GVTTI-AGGKTVRNGGHVDG 191
Cdd:cd14952   9 LDGPGGVAVDAAGNVYVADSGNNRVLKLAAGstTQTVLpFTGLYQPQGVAVDA 61
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
120-228 5.75e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.52  E-value: 5.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 120 RLVTGSPEGYPGHVDGRLRDAKLNHPKGLTVDDRGNIYVADTVNNAIRKISeggvttIAGGKTVRNGGHVDGPSEDAkFS 199
Cdd:COG3391  46 GAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVID------LATGKVVATIPVGGGPRGLA-VD 118
                        90       100       110
                ....*....|....*....|....*....|..
gi 30698020 200 NDFDVVYVGSSCS--LLVID-RGNKAIREIQL 228
Cdd:COG3391 119 PDGGRLYVADSGNgrVSVIDtATGKVVATIPV 150
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
138-247 7.27e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 38.30  E-value: 7.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020 138 RDAKLNHPKGLTVDDRGNIYVADTVNNAIRKISEGGvTTIAGGKTVRNG-GHVDGPSEDAkFSNDfDVVYVGSSCS--LL 214
Cdd:cd14954 113 KNGQFNYPWGVAVDSEGRIYVSDTRNHRVQVFDSDG-QFIRKFGFEGAGpGQLDSPRGVA-VNPD-GNIVVSDFNNhrLQ 189
                        90       100       110
                ....*....|....*....|....*....|....
gi 30698020 215 VIDRGNKAIREiqlhFDDCAYQYGS-GFPLGIAV 247
Cdd:cd14954 190 VFDPDGQFLRF----FGSEGSGNGQfKRPRGVAV 219
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
83-173 7.64e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 38.34  E-value: 7.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30698020  83 IEPYSIEVLPNGELLILDSENSNIY----------KISSSLsLYSRPRLVTGSPEG---Y---PGH-------VDGRLR- 138
Cdd:cd14962  57 VSPIGVAIDANGNLYVSDAELGKVFvfdrdgkflrAIGAGA-LFKRPTGIAVDPAGkrlYvvdTLAhkvkvfdLDGRLLf 135
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 30698020 139 --------DAKLNHPKGLTVDDRGNIYVADTVNNAIRKISEGG 173
Cdd:cd14962 136 digkrgsgPGEFNLPTDLAVDRDGNLYVTDTMNFRVQIFDADG 178
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
139-187 9.98e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 37.95  E-value: 9.98e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 30698020 139 DAKLNHPKGLTVDDRGNIYVADTVNNAI----------RKISEGGVTTIAGGKTVRNGG 187
Cdd:cd14962  53 PNRFVSPIGVAIDANGNLYVSDAELGKVfvfdrdgkflRAIGAGALFKRPTGIAVDPAG 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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