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Conserved domains on  [gi|145337329|ref|NP_177104|]
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Early-responsive to dehydration stress protein (ERD4) [Arabidopsis thaliana]

Protein Classification

OSCA/TMEM63 family ion channel( domain architecture ID 13432816)

OSCA/TMEM63 family ion channel is an an osmosensitive calcium-permeable cation channel that converts mechanical stimuli into electric signals

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
RSN1_7TM pfam02714
Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane ...
350-614 2.41e-79

Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter. The family is the 7TM region of osmosensitive calcium-permeable cation channels.


:

Pssm-ID: 460661  Cd Length: 273  Bit Score: 254.37  E-value: 2.41e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329  350 KILVVFACLLLTILFLVPVVLVQGLTNLPALEFMFPFLSLILSM-KVVSQIITGYLPSLILQTSLKVVPPTMEFLSSIQG 428
Cdd:pfam02714   2 RLIVNLAIFLLIIFWAIPVAFVGLLSNLETLTKVWPFLKWILELpPKLLGLVTGLLPPLLLSLLMALLPIILRFLSKLQG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329  429 HICHSDIQKSACNKVIWFTIWNVFFATVFSGSAFYKLSVILD-PKQIPLKLAVAVPAQASFFIAYVVTTGWTDTLTELFR 507
Cdd:pfam02714  82 APSRSDIELSVQSKYFAFLVVNVFLVFTLASSASSLIEQIIDnPTSIPTLLATNLPKASNFFITYILLQGLSGAAGELLQ 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329  508 VVPFMVSYIKRSFEPSDENEFV-----VPPMRYHRDTPRVLFFGLLGITYFFLAPLILPFILLYFILAYIIYRNQFMNVY 582
Cdd:pfam02714 162 LGPLILFYIKRKFLDKTPRDKYeryttPPSFDYGTVYPVFLLIFTIGLIYSVIAPLILPFGLVYFGLGYFVYKYQLLYVY 241
                         250       260       270
                  ....*....|....*....|....*....|..
gi 145337329  583 APKFDTGGMFWPMIHYTMIFSLVLMQAIAIGL 614
Cdd:pfam02714 242 VTKYESGGRFWPRALNRLLVGLYLFQLCLIGL 273
COG5594 super family cl35025
Uncharacterized integral membrane protein [Function unknown];
2-649 9.20e-67

Uncharacterized integral membrane protein [Function unknown];


The actual alignment was detected with superfamily member COG5594:

Pssm-ID: 227881 [Multi-domain]  Cd Length: 827  Bit Score: 235.78  E-value: 9.20e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329   2 LLSALLMSVGINSCLCVLLFILYSVLRKqpRNYEVFLPRRLANGtykrRRNKVARYIPS--LKWIWKSWRPTEKELMESS 79
Cdd:COG5594   20 STSAVITQLVFAGLIFLVFLILFLILRK--RWKRLYAPRTNFDG----QNECLPEPNPSsyWGWLEPLVKIPDEFLLQYA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329  80 GLDGVVFMRMITFSLKVFLFAGIIGVFVLLPVNCFGDQLTVIDyaDWSANSLDLFSVANLKVRSqWLWVHFGAIYLVTVF 159
Cdd:COG5594   94 GLDGYFFLRFLKMLIKLLFILSLILIPILLPVNYHFQKATNGN--SDSESGLDKLSISNVSPSN-RLYAHVFLSWFFFGY 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 160 VCCLLYFEFRYIalKRIEHFYSSKPKPEQFTILVRNIPSSDGSSVSDTVDRFFGENHSSTYF---------SHVVIHRTS 230
Cdd:COG5594  171 VLFIIFRELRFY--VVLRQAYLRSPLYQQSLLTLQNNLSSRTVLISGLPSELRSDEELKELFdklkvgeidSDVLCRDLG 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 231 KLRSVVDK----AKKLYKEVK----------HKKPVKKTPMRFFSRKDNTEGHYESVLQEMEQNIRLGQAEVSAPGKEVR 296
Cdd:COG5594  249 TLQELYKErdkiLKKLEKALNellnkllkksHLKTNKKSGKLTPSRKKEFEILPEYVPDKKRPKHRIKKLNKGIFGKKVD 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 297 A------------------------------AFVSFKSRYGAATALHMPQSINPTYWL-TEPAPEPHDVHWPFFSAS--- 342
Cdd:COG5594  329 AidyysakltkldaeienarkslyentptksGFITFKSQASAQIAAQSQIYSRVLGKLkVEIAPAPNDIIWDNLRLSrke 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 343 -FMQKWLAKILVVfaclLLTILFLVPVVLVQGLTNLPALEFMFPFLSLILSM-KVVSQIITGYLPSLILQTSLKVVPPTM 420
Cdd:COG5594  409 rLFKRISANILFI----LLIILWAFPVAFVGTISNLNTLSSLWPFLKFILKDpPFLAGILTGLLPTVALSLLMSIVPYFI 484
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 421 EFLSSIQGHICHSDIQKSACNKVIWFTIWNVFFATVFSGSAFYK-LSVILDPKQIPLKLAVAVPAQASFFIAYVVTTGWT 499
Cdd:COG5594  485 RWLSYMQGLVSYSEEEIYVQNKYFAFLFVNLFLVVTLASSFSSIvWSLLKEPTSIMTLLANNLPKASNFFISYIILQGLS 564
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 500 DTLTELFRVVPFMVSYIKRSFEPS----DENEFVVPP-MRYHRDTPRVLFFGLLGITYFFLAPLILPFILLYFILAYIIY 574
Cdd:COG5594  565 GFPGTLLQIVPLLLSLVLGKFKDStprqKWNRLETPPsFQFGTVLPQPILLFTITICYSIISPLILLFGAVYFILNYLAY 644
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145337329 575 RNQFMNVYAPKFDTGGMFWPMIHYTMIFSLVLMQAIAIGLFALKKMELATYLLVPLPVFTLLFNEFCRKRFMPIF 649
Cdd:COG5594  645 KYNLIYVSNHSPESGGGYWPRALFQIIVGLYLFQVCLLGLFSLAKGWGLSVLLFPLIVFTVIFHYYFKKMFDPLS 719
 
Name Accession Description Interval E-value
RSN1_7TM pfam02714
Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane ...
350-614 2.41e-79

Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter. The family is the 7TM region of osmosensitive calcium-permeable cation channels.


Pssm-ID: 460661  Cd Length: 273  Bit Score: 254.37  E-value: 2.41e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329  350 KILVVFACLLLTILFLVPVVLVQGLTNLPALEFMFPFLSLILSM-KVVSQIITGYLPSLILQTSLKVVPPTMEFLSSIQG 428
Cdd:pfam02714   2 RLIVNLAIFLLIIFWAIPVAFVGLLSNLETLTKVWPFLKWILELpPKLLGLVTGLLPPLLLSLLMALLPIILRFLSKLQG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329  429 HICHSDIQKSACNKVIWFTIWNVFFATVFSGSAFYKLSVILD-PKQIPLKLAVAVPAQASFFIAYVVTTGWTDTLTELFR 507
Cdd:pfam02714  82 APSRSDIELSVQSKYFAFLVVNVFLVFTLASSASSLIEQIIDnPTSIPTLLATNLPKASNFFITYILLQGLSGAAGELLQ 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329  508 VVPFMVSYIKRSFEPSDENEFV-----VPPMRYHRDTPRVLFFGLLGITYFFLAPLILPFILLYFILAYIIYRNQFMNVY 582
Cdd:pfam02714 162 LGPLILFYIKRKFLDKTPRDKYeryttPPSFDYGTVYPVFLLIFTIGLIYSVIAPLILPFGLVYFGLGYFVYKYQLLYVY 241
                         250       260       270
                  ....*....|....*....|....*....|..
gi 145337329  583 APKFDTGGMFWPMIHYTMIFSLVLMQAIAIGL 614
Cdd:pfam02714 242 VTKYESGGRFWPRALNRLLVGLYLFQLCLIGL 273
COG5594 COG5594
Uncharacterized integral membrane protein [Function unknown];
2-649 9.20e-67

Uncharacterized integral membrane protein [Function unknown];


Pssm-ID: 227881 [Multi-domain]  Cd Length: 827  Bit Score: 235.78  E-value: 9.20e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329   2 LLSALLMSVGINSCLCVLLFILYSVLRKqpRNYEVFLPRRLANGtykrRRNKVARYIPS--LKWIWKSWRPTEKELMESS 79
Cdd:COG5594   20 STSAVITQLVFAGLIFLVFLILFLILRK--RWKRLYAPRTNFDG----QNECLPEPNPSsyWGWLEPLVKIPDEFLLQYA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329  80 GLDGVVFMRMITFSLKVFLFAGIIGVFVLLPVNCFGDQLTVIDyaDWSANSLDLFSVANLKVRSqWLWVHFGAIYLVTVF 159
Cdd:COG5594   94 GLDGYFFLRFLKMLIKLLFILSLILIPILLPVNYHFQKATNGN--SDSESGLDKLSISNVSPSN-RLYAHVFLSWFFFGY 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 160 VCCLLYFEFRYIalKRIEHFYSSKPKPEQFTILVRNIPSSDGSSVSDTVDRFFGENHSSTYF---------SHVVIHRTS 230
Cdd:COG5594  171 VLFIIFRELRFY--VVLRQAYLRSPLYQQSLLTLQNNLSSRTVLISGLPSELRSDEELKELFdklkvgeidSDVLCRDLG 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 231 KLRSVVDK----AKKLYKEVK----------HKKPVKKTPMRFFSRKDNTEGHYESVLQEMEQNIRLGQAEVSAPGKEVR 296
Cdd:COG5594  249 TLQELYKErdkiLKKLEKALNellnkllkksHLKTNKKSGKLTPSRKKEFEILPEYVPDKKRPKHRIKKLNKGIFGKKVD 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 297 A------------------------------AFVSFKSRYGAATALHMPQSINPTYWL-TEPAPEPHDVHWPFFSAS--- 342
Cdd:COG5594  329 AidyysakltkldaeienarkslyentptksGFITFKSQASAQIAAQSQIYSRVLGKLkVEIAPAPNDIIWDNLRLSrke 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 343 -FMQKWLAKILVVfaclLLTILFLVPVVLVQGLTNLPALEFMFPFLSLILSM-KVVSQIITGYLPSLILQTSLKVVPPTM 420
Cdd:COG5594  409 rLFKRISANILFI----LLIILWAFPVAFVGTISNLNTLSSLWPFLKFILKDpPFLAGILTGLLPTVALSLLMSIVPYFI 484
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 421 EFLSSIQGHICHSDIQKSACNKVIWFTIWNVFFATVFSGSAFYK-LSVILDPKQIPLKLAVAVPAQASFFIAYVVTTGWT 499
Cdd:COG5594  485 RWLSYMQGLVSYSEEEIYVQNKYFAFLFVNLFLVVTLASSFSSIvWSLLKEPTSIMTLLANNLPKASNFFISYIILQGLS 564
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 500 DTLTELFRVVPFMVSYIKRSFEPS----DENEFVVPP-MRYHRDTPRVLFFGLLGITYFFLAPLILPFILLYFILAYIIY 574
Cdd:COG5594  565 GFPGTLLQIVPLLLSLVLGKFKDStprqKWNRLETPPsFQFGTVLPQPILLFTITICYSIISPLILLFGAVYFILNYLAY 644
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145337329 575 RNQFMNVYAPKFDTGGMFWPMIHYTMIFSLVLMQAIAIGLFALKKMELATYLLVPLPVFTLLFNEFCRKRFMPIF 649
Cdd:COG5594  645 KYNLIYVSNHSPESGGGYWPRALFQIIVGLYLFQVCLLGLFSLAKGWGLSVLLFPLIVFTVIFHYYFKKMFDPLS 719
PHM7_cyt pfam14703
Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic ...
188-338 8.70e-35

Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic domain of integral membrane proteins, such as yeast PHM7 and TM63A_HUMAN TRANSMEMBRANE PROTEIN 63A, SwissProt:O94886. This domain usually precedes the 7TM region, pfam02714, and follows a RSN1_TM, pfam13967. Fold recognition programs consistently and with high significance predict this domain to be distantly homologous to RNA binding proteins from the RRM clan.


Pssm-ID: 464272  Cd Length: 164  Bit Score: 129.75  E-value: 8.70e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329  188 QFTILVRNIPSSDGSSvsDTVDRFFGENHSSTYFSHVVI-HRTSKLRSVVDKAKKLYKE--------VKHKKPVKKTPMR 258
Cdd:pfam14703   1 SRTVLVTGIPKDLRSE--EKLRSFFEELYPGTVVERVQIvRDVKKLPKLVEEREKAVRKleaalakyLKNGKKPKKRPTH 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329  259 ------FFSRKDNTEGHYESVLQEMEQNIRLGQAEVSApgKEVRAAFVSFKSRYGAATALHM--PQSINPTYWLTEPAPE 330
Cdd:pfam14703  79 klgflgLFGKKVDAIDYYTEKLEELEEEIEEEREKVDK--KPLGAAFVTFKSERSAAAAAAQinPQLMHPKGWTVELAPE 156

                  ....*...
gi 145337329  331 PHDVHWPF 338
Cdd:pfam14703 157 PRDVIWEN 164
 
Name Accession Description Interval E-value
RSN1_7TM pfam02714
Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane ...
350-614 2.41e-79

Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter. The family is the 7TM region of osmosensitive calcium-permeable cation channels.


Pssm-ID: 460661  Cd Length: 273  Bit Score: 254.37  E-value: 2.41e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329  350 KILVVFACLLLTILFLVPVVLVQGLTNLPALEFMFPFLSLILSM-KVVSQIITGYLPSLILQTSLKVVPPTMEFLSSIQG 428
Cdd:pfam02714   2 RLIVNLAIFLLIIFWAIPVAFVGLLSNLETLTKVWPFLKWILELpPKLLGLVTGLLPPLLLSLLMALLPIILRFLSKLQG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329  429 HICHSDIQKSACNKVIWFTIWNVFFATVFSGSAFYKLSVILD-PKQIPLKLAVAVPAQASFFIAYVVTTGWTDTLTELFR 507
Cdd:pfam02714  82 APSRSDIELSVQSKYFAFLVVNVFLVFTLASSASSLIEQIIDnPTSIPTLLATNLPKASNFFITYILLQGLSGAAGELLQ 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329  508 VVPFMVSYIKRSFEPSDENEFV-----VPPMRYHRDTPRVLFFGLLGITYFFLAPLILPFILLYFILAYIIYRNQFMNVY 582
Cdd:pfam02714 162 LGPLILFYIKRKFLDKTPRDKYeryttPPSFDYGTVYPVFLLIFTIGLIYSVIAPLILPFGLVYFGLGYFVYKYQLLYVY 241
                         250       260       270
                  ....*....|....*....|....*....|..
gi 145337329  583 APKFDTGGMFWPMIHYTMIFSLVLMQAIAIGL 614
Cdd:pfam02714 242 VTKYESGGRFWPRALNRLLVGLYLFQLCLIGL 273
COG5594 COG5594
Uncharacterized integral membrane protein [Function unknown];
2-649 9.20e-67

Uncharacterized integral membrane protein [Function unknown];


Pssm-ID: 227881 [Multi-domain]  Cd Length: 827  Bit Score: 235.78  E-value: 9.20e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329   2 LLSALLMSVGINSCLCVLLFILYSVLRKqpRNYEVFLPRRLANGtykrRRNKVARYIPS--LKWIWKSWRPTEKELMESS 79
Cdd:COG5594   20 STSAVITQLVFAGLIFLVFLILFLILRK--RWKRLYAPRTNFDG----QNECLPEPNPSsyWGWLEPLVKIPDEFLLQYA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329  80 GLDGVVFMRMITFSLKVFLFAGIIGVFVLLPVNCFGDQLTVIDyaDWSANSLDLFSVANLKVRSqWLWVHFGAIYLVTVF 159
Cdd:COG5594   94 GLDGYFFLRFLKMLIKLLFILSLILIPILLPVNYHFQKATNGN--SDSESGLDKLSISNVSPSN-RLYAHVFLSWFFFGY 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 160 VCCLLYFEFRYIalKRIEHFYSSKPKPEQFTILVRNIPSSDGSSVSDTVDRFFGENHSSTYF---------SHVVIHRTS 230
Cdd:COG5594  171 VLFIIFRELRFY--VVLRQAYLRSPLYQQSLLTLQNNLSSRTVLISGLPSELRSDEELKELFdklkvgeidSDVLCRDLG 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 231 KLRSVVDK----AKKLYKEVK----------HKKPVKKTPMRFFSRKDNTEGHYESVLQEMEQNIRLGQAEVSAPGKEVR 296
Cdd:COG5594  249 TLQELYKErdkiLKKLEKALNellnkllkksHLKTNKKSGKLTPSRKKEFEILPEYVPDKKRPKHRIKKLNKGIFGKKVD 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 297 A------------------------------AFVSFKSRYGAATALHMPQSINPTYWL-TEPAPEPHDVHWPFFSAS--- 342
Cdd:COG5594  329 AidyysakltkldaeienarkslyentptksGFITFKSQASAQIAAQSQIYSRVLGKLkVEIAPAPNDIIWDNLRLSrke 408
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 343 -FMQKWLAKILVVfaclLLTILFLVPVVLVQGLTNLPALEFMFPFLSLILSM-KVVSQIITGYLPSLILQTSLKVVPPTM 420
Cdd:COG5594  409 rLFKRISANILFI----LLIILWAFPVAFVGTISNLNTLSSLWPFLKFILKDpPFLAGILTGLLPTVALSLLMSIVPYFI 484
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 421 EFLSSIQGHICHSDIQKSACNKVIWFTIWNVFFATVFSGSAFYK-LSVILDPKQIPLKLAVAVPAQASFFIAYVVTTGWT 499
Cdd:COG5594  485 RWLSYMQGLVSYSEEEIYVQNKYFAFLFVNLFLVVTLASSFSSIvWSLLKEPTSIMTLLANNLPKASNFFISYIILQGLS 564
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329 500 DTLTELFRVVPFMVSYIKRSFEPS----DENEFVVPP-MRYHRDTPRVLFFGLLGITYFFLAPLILPFILLYFILAYIIY 574
Cdd:COG5594  565 GFPGTLLQIVPLLLSLVLGKFKDStprqKWNRLETPPsFQFGTVLPQPILLFTITICYSIISPLILLFGAVYFILNYLAY 644
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145337329 575 RNQFMNVYAPKFDTGGMFWPMIHYTMIFSLVLMQAIAIGLFALKKMELATYLLVPLPVFTLLFNEFCRKRFMPIF 649
Cdd:COG5594  645 KYNLIYVSNHSPESGGGYWPRALFQIIVGLYLFQVCLLGLFSLAKGWGLSVLLFPLIVFTVIFHYYFKKMFDPLS 719
PHM7_cyt pfam14703
Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic ...
188-338 8.70e-35

Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic domain of integral membrane proteins, such as yeast PHM7 and TM63A_HUMAN TRANSMEMBRANE PROTEIN 63A, SwissProt:O94886. This domain usually precedes the 7TM region, pfam02714, and follows a RSN1_TM, pfam13967. Fold recognition programs consistently and with high significance predict this domain to be distantly homologous to RNA binding proteins from the RRM clan.


Pssm-ID: 464272  Cd Length: 164  Bit Score: 129.75  E-value: 8.70e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329  188 QFTILVRNIPSSDGSSvsDTVDRFFGENHSSTYFSHVVI-HRTSKLRSVVDKAKKLYKE--------VKHKKPVKKTPMR 258
Cdd:pfam14703   1 SRTVLVTGIPKDLRSE--EKLRSFFEELYPGTVVERVQIvRDVKKLPKLVEEREKAVRKleaalakyLKNGKKPKKRPTH 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329  259 ------FFSRKDNTEGHYESVLQEMEQNIRLGQAEVSApgKEVRAAFVSFKSRYGAATALHM--PQSINPTYWLTEPAPE 330
Cdd:pfam14703  79 klgflgLFGKKVDAIDYYTEKLEELEEEIEEEREKVDK--KPLGAAFVTFKSERSAAAAAAQinPQLMHPKGWTVELAPE 156

                  ....*...
gi 145337329  331 PHDVHWPF 338
Cdd:pfam14703 157 PRDVIWEN 164
RSN1_TM pfam13967
Late exocytosis, associated with Golgi transport; This family represents the first three ...
5-167 1.91e-29

Late exocytosis, associated with Golgi transport; This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localized to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface.


Pssm-ID: 433613  Cd Length: 158  Bit Score: 114.21  E-value: 1.91e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329    5 ALLMSVGINSCLCVLLFILYSVLRkqPRNYEVFLPRRLANGtyKRRRNKVARYIPSLKWIWKSWRPTEKELMESSGLDGV 84
Cdd:pfam13967   1 AFLTSLVINLVIALVFLLLFSILR--PKNKRVYAPRTYLAP--EEERTPPLPGTGLFGWIPPLLKIPDEEILQHAGLDAY 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145337329   85 VFMRMITFSLKVFLFAGIIGVFVLLPVNCFGDQLTVIDYaDWSANSLDLFSVANLKVRSQWLWVHFGAIYLVTVFVCCLL 164
Cdd:pfam13967  77 VFLRFLKMLIKIFLVGCLIGWPILLPVNATGGNGEDDGD-SLTRTGLDKLSSSNNVEGSNRLWAHVVVAYIFTGFVLYLL 155

                  ...
gi 145337329  165 YFE 167
Cdd:pfam13967 156 YRE 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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