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Conserved domains on  [gi|15219751|ref|NP_176853|]
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Zinc finger C-x8-C-x5-C-x3-H type family protein [Arabidopsis thaliana]

Protein Classification

CTH1 family zinc finger protein( domain architecture ID 1004917)

CTH1 family zinc finger protein similar to Homo sapiens mRNA decay activator protein ZFP36 that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis

CATH:  4.10.1000.10
Gene Ontology:  GO:0046872|GO:0003676
PubMed:  12665246|11179890
SCOP:  4003893

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CTH1 super family cl34885
CCCH-type Zn-finger protein [General function prediction only];
230-300 4.37e-12

CCCH-type Zn-finger protein [General function prediction only];


The actual alignment was detected with superfamily member COG5063:

Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 65.84  E-value: 4.37e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15219751 230 QGMMKTELCNKWQETGACCYGDNCQFAHGIDELRPVIRHPRYKTEVCRMMVTGAMCPYGHRCHFRH-SLTDQ 300
Cdd:COG5063 110 YGLYKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFISlPLTDI 181
 
Name Accession Description Interval E-value
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
230-300 4.37e-12

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 65.84  E-value: 4.37e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15219751 230 QGMMKTELCNKWQETGACCYGDNCQFAHGIDELRPVIRHPRYKTEVCRMMVTGAMCPYGHRCHFRH-SLTDQ 300
Cdd:COG5063 110 YGLYKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFISlPLTDI 181
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
234-258 5.00e-07

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 45.26  E-value: 5.00e-07
                          10        20
                  ....*....|....*....|....*
gi 15219751   234 KTELCNKWQETGACCYGDNCQFAHG 258
Cdd:pfam00642   2 KTELCRFFLRTGYCKYGDRCKFAHG 26
ZnF_C3H1 smart00356
zinc finger;
234-258 4.91e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 36.84  E-value: 4.91e-04
                           10        20
                   ....*....|....*....|....*
gi 15219751    234 KTELCNKWqETGACCYGDNCQFAHG 258
Cdd:smart00356   3 KTELCKFF-KRGYCPRGDRCKFAHP 26
 
Name Accession Description Interval E-value
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
230-300 4.37e-12

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 65.84  E-value: 4.37e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 15219751 230 QGMMKTELCNKWQETGACCYGDNCQFAHGIDELRPVIRHPRYKTEVCRMMVTGAMCPYGHRCHFRH-SLTDQ 300
Cdd:COG5063 110 YGLYKTEMLRSSTEIPYCRYPDKNPFAHSKAISSLAQTHPKYKTESLEVFINPGYVPYSKRCCFISlPLTDI 181
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
234-295 1.28e-10

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 61.61  E-value: 1.28e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15219751 234 KTELCNKWQETGACCYGDNCQFAHGIDELRPVIRHPR--YKTEVCRMMVTGAMCPYGHRCHFRH 295
Cdd:COG5063 273 RTEPCINWEKSGYCPYGLRCCFKHGDDSDIEMYEEASlgYLDGPCRTRAKGGAFPSGGAVCKSF 336
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
234-258 5.00e-07

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 45.26  E-value: 5.00e-07
                          10        20
                  ....*....|....*....|....*
gi 15219751   234 KTELCNKWQETGACCYGDNCQFAHG 258
Cdd:pfam00642   2 KTELCRFFLRTGYCKYGDRCKFAHG 26
CTH1 COG5063
CCCH-type Zn-finger protein [General function prediction only];
236-305 7.56e-07

CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227395 [Multi-domain]  Cd Length: 351  Bit Score: 50.05  E-value: 7.56e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15219751 236 ELCNKWQETGACCY---GDNCQFA---HGIDELRPVIRHPRYKTEVCRMMVTGAMCPYGHRCHFRHSltDQERMMM 305
Cdd:COG5063 231 ELCESFTRKGTCPYwisGVKCQFAcrgHGLNELKSKKKKQNFRTEPCINWEKSGYCPYGLRCCFKHG--DDSDIEM 304
ZnF_C3H1 smart00356
zinc finger;
234-258 4.91e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 36.84  E-value: 4.91e-04
                           10        20
                   ....*....|....*....|....*
gi 15219751    234 KTELCNKWqETGACCYGDNCQFAHG 258
Cdd:smart00356   3 KTELCKFF-KRGYCPRGDRCKFAHP 26
ZnF_C3H1 smart00356
zinc finger;
270-297 1.01e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 36.07  E-value: 1.01e-03
                           10        20
                   ....*....|....*....|....*...
gi 15219751    270 RYKTEVCRMMVTGAmCPYGHRCHFRHSL 297
Cdd:smart00356   1 KYKTELCKFFKRGY-CPRGDRCKFAHPL 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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