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Conserved domains on  [gi|15220246|ref|NP_175184|]
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MATE efflux family protein [Arabidopsis thaliana]

Protein Classification

MATE family efflux transporter( domain architecture ID 10192067)

MATE (multidrug and toxic compound extrusion) family efflux transporter functions in protecting cells against oxidative stress and bile salts and may be part of the SOS system; similar to Arabidopsis thaliana MATE proteins which confer aluminum tolerance

Gene Ontology:  GO:0016020|GO:0015297|GO:0022857
PubMed:  26246409|33774036|31866287
TCDB:  2.A.66

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 35-470 8.01e-168

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


:

Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 480.15  E-value: 8.01e-168
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  35 ESKRLWELAGPAIFTAISQYSLGALTQTFSGRLGELELAAVSVENSVISGLAFGVMLGMGSALETLCGQAYGAGQIRMMG 114
Cdd:cd13132   1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 115 IYMQRSWVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGV 194
Cdd:cd13132  81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 195 VLVIHAVFSWLFILYFKWGLVGAAITLNTSWWLIVIGQLLYILITKSDGA-WTGFSMLAFRDLYGFVKLSLASALMLCLE 273
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKAtWGGFSREAFRGWGPFLKLAIPSALMLCLE 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 274 FWYLMVLVVVTGLLPnPLIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLIGIVCM 353
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 354 IVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACYYIIGLPAGLVLGFTL 433
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 15220246 434 DLGVQGIWGGMVAGICLQTLILIGIIYFTNWNKEAEQ 470
Cdd:cd13132 400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
 
Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 35-470 8.01e-168

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 480.15  E-value: 8.01e-168
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  35 ESKRLWELAGPAIFTAISQYSLGALTQTFSGRLGELELAAVSVENSVISGLAFGVMLGMGSALETLCGQAYGAGQIRMMG 114
Cdd:cd13132   1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 115 IYMQRSWVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGV 194
Cdd:cd13132  81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 195 VLVIHAVFSWLFILYFKWGLVGAAITLNTSWWLIVIGQLLYILITKSDGA-WTGFSMLAFRDLYGFVKLSLASALMLCLE 273
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKAtWGGFSREAFRGWGPFLKLAIPSALMLCLE 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 274 FWYLMVLVVVTGLLPnPLIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLIGIVCM 353
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 354 IVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACYYIIGLPAGLVLGFTL 433
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 15220246 434 DLGVQGIWGGMVAGICLQTLILIGIIYFTNWNKEAEQ 470
Cdd:cd13132 400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
37-456 1.03e-51

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 180.73  E-value: 1.03e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  37 KRLWELAGPAIFTAISQYSLGALTQTFSGRLGELELAAVSVENSVISgLAFGVMLGMGSALETLCGQAYGAGQIRMMGIY 116
Cdd:COG0534   8 KLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFF-LLIALGIGLGVGGTALVAQALGAGDREEARRV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 117 MQRS-WVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGVV 195
Cdd:COG0534  87 LGQAlLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 196 LVIHAVFSWLFILYFKWGLVGAAITLNTSWWLIVIGQLLYILITKSDGAWTGFSM-LAFRDLYGFVKLSLASALMLCLEF 274
Cdd:COG0534 167 NVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLrPDRKILKRILRIGLPAGLQQLAES 246

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 275 WYLMVLVVVTGLLPNplIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLIGIVCMI 354
Cdd:COG0534 247 LGFLVLNALVARLGT--AAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLAL 324

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 355 VVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACYYIIGLPAGLVLGFtLD 434
Cdd:COG0534 325 LLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF-LG 403

                       410       420
                ....*....|....*....|..
gi 15220246 435 LGVQGIWGGMVAGICLQTLILI 456
Cdd:COG0534 404 LGLTGVWLALPIGEVLRALLLL 425
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 45-373 1.21e-51

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 178.21  E-value: 1.21e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246    45 PAIFTAISQYSLGALTQTFSGRLGELELAAVSVENSViSGLAFGVMLGMGSALETLCGQAYGAGQIRMMGIYMQRSWVIL 124
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSV-FMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246   125 FTTALFLLPV-YIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGVVLVIHAVFS 203
Cdd:TIGR00797  80 LLLGLPVLLVgYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246   204 WLFIL--YFKWGLVGAAITLNTSWWLIVIGQLLYILITKSDG-AWTGFSMLAFRDLYGFVKLSLASALMLCLEFWYLMVL 280
Cdd:TIGR00797 160 YILIFgkFGFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGlKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246   281 VVVTGLLPNplIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLIGIVCMIVVLATK 360
Cdd:TIGR00797 240 ALLVARLGS--IALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317

                         330
                  ....*....|...
gi 15220246   361 DSFPYLFTSSEAV 373
Cdd:TIGR00797 318 EFIARLFTNDPEV 330
MatE pfam01554
MatE; The MatE domain
 45-205 1.27e-26

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 105.34  E-value: 1.27e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246    45 PAIFTAISQYSLGALTQTFSGRLGELELAAVSVENSvISGLAFGVMLGMGSALETLCGQAYGAGQIRMMGIYMQRSWVIL 124
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANS-IASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246   125 FTTALFL-LPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGVVLVIHAVFS 203
Cdd:pfam01554  80 LLLSLPIaLLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159


                  ..
gi 15220246   204 WL 205
Cdd:pfam01554 160 YL 161
PRK01766 PRK01766
multidrug efflux protein; Reviewed
 30-448 5.86e-25

multidrug efflux protein; Reviewed


Pssm-ID: 234981 [Multi-domain]  Cd Length: 456  Bit Score: 107.21  E-value: 5.86e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246   30 KEFGEESKRLWELAGPAIFTAISQYSLGALTQTFSGRLGELELAAVSVENS----VISGLAfGVMLgmgsALETLCGQAY 105
Cdd:PRK01766   5 QKYKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSiwlpVILFGH-GLLL----ALTPIVAQLN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  106 GAGQIRMMG-IYMQRSWVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKF---ALWMIPQLFAYAAnfpIQKFLQS 181
Cdd:PRK01766  80 GAGRRERIAhQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYlhaLLWGIPAYLLYQV---LRSFIDG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  182 QRKVLVMAWISGVVLVIHAVFSWLFIlYFKWGL-----VGAAITLNTSWWLIVIGQLLYILITKSD---GAWTGFSMLAF 253
Cdd:PRK01766 157 LGKTKPTMVIGFLGLLINIPLNYIFI-YGKFGFpelggVGCGVATAIVYWVMFLAMLIYIKRARRFrdfRLFKGLYKPDW 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  254 RDLYGFVKLSLASALMLCLEfwylMVLVVVTGLLPNPL--IPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNA 331
Cdd:PRK01766 236 AVIKRLLKLGLPIGLAIFFE----VSLFAVVTLLVSPLgtVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRT 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  332 ALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVA 411
Cdd:PRK01766 312 LDARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIF 391

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 15220246  412 YVNIACYYIIGLPAGLVLGFTLDLGVQGIWGGMVAGI 448
Cdd:PRK01766 392 FITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGL 428
 
Name Accession Description Interval E-value
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
 35-470 8.01e-168

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 480.15  E-value: 8.01e-168
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  35 ESKRLWELAGPAIFTAISQYSLGALTQTFSGRLGELELAAVSVENSVISGLAFGVMLGMGSALETLCGQAYGAGQIRMMG 114
Cdd:cd13132   1 EAKKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVTGFSILLGLASALDTLCGQAFGAKNYKLVG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 115 IYMQRSWVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGV 194
Cdd:cd13132  81 VYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 195 VLVIHAVFSWLFILYFKWGLVGAAITLNTSWWLIVIGQLLYILITKSDGA-WTGFSMLAFRDLYGFVKLSLASALMLCLE 273
Cdd:cd13132 161 ALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKAtWGGFSREAFRGWGPFLKLAIPSALMLCLE 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 274 FWYLMVLVVVTGLLPnPLIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLIGIVCM 353
Cdd:cd13132 241 WWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVA 319

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 354 IVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACYYIIGLPAGLVLGFTL 433
Cdd:cd13132 320 ILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLIGLPVGLLLAFVL 399

                       410       420       430
                ....*....|....*....|....*....|....*..
gi 15220246 434 DLGVQGIWGGMVAGICLQTLILIGIIYFTNWNKEAEQ 470
Cdd:cd13132 400 GLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
37-456 1.03e-51

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 180.73  E-value: 1.03e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  37 KRLWELAGPAIFTAISQYSLGALTQTFSGRLGELELAAVSVENSVISgLAFGVMLGMGSALETLCGQAYGAGQIRMMGIY 116
Cdd:COG0534   8 KLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFF-LLIALGIGLGVGGTALVAQALGAGDREEARRV 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 117 MQRS-WVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGVV 195
Cdd:COG0534  87 LGQAlLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 196 LVIHAVFSWLFILYFKWGLVGAAITLNTSWWLIVIGQLLYILITKSDGAWTGFSM-LAFRDLYGFVKLSLASALMLCLEF 274
Cdd:COG0534 167 NVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLrPDRKILKRILRIGLPAGLQQLAES 246

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 275 WYLMVLVVVTGLLPNplIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLIGIVCMI 354
Cdd:COG0534 247 LGFLVLNALVARLGT--AAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLALGIGLLLAL 324

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 355 VVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACYYIIGLPAGLVLGFtLD 434
Cdd:COG0534 325 LLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAF-LG 403

                       410       420
                ....*....|....*....|..
gi 15220246 435 LGVQGIWGGMVAGICLQTLILI 456
Cdd:COG0534 404 LGLTGVWLALPIGEVLRALLLL 425
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
 45-373 1.21e-51

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 178.21  E-value: 1.21e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246    45 PAIFTAISQYSLGALTQTFSGRLGELELAAVSVENSViSGLAFGVMLGMGSALETLCGQAYGAGQIRMMGIYMQRSWVIL 124
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSV-FMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246   125 FTTALFLLPV-YIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGVVLVIHAVFS 203
Cdd:TIGR00797  80 LLLGLPVLLVgYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246   204 WLFIL--YFKWGLVGAAITLNTSWWLIVIGQLLYILITKSDG-AWTGFSMLAFRDLYGFVKLSLASALMLCLEFWYLMVL 280
Cdd:TIGR00797 160 YILIFgkFGFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGlKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246   281 VVVTGLLPNplIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLIGIVCMIVVLATK 360
Cdd:TIGR00797 240 ALLVARLGS--IALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFR 317

                         330
                  ....*....|...
gi 15220246   361 DSFPYLFTSSEAV 373
Cdd:TIGR00797 318 EFIARLFTNDPEV 330
MATE_NorM_like cd13131
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ...
 35-448 1.63e-42

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.


Pssm-ID: 240536 [Multi-domain]  Cd Length: 435  Bit Score: 156.12  E-value: 1.63e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  35 ESKRLWELAGPAIFTAISQYSLGALTQTFSGRLGELELAAVSVENSVISgLAFGVMLGMGSALETLCGQAYGAGQIRMMG 114
Cdd:cd13131   1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWF-PVFTFGMGLLLAVTPLVAQAHGAGDRRRIR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 115 IYMQRSWVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGV 194
Cdd:cd13131  80 RAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 195 VLVIHAVFSWLFIlYFKWGL-----VGAAITLNTSWWLIVIGQLLYIL---ITKSDGAWTGFSMLAFRDLYGFVKLSLAS 266
Cdd:cd13131 160 ALVLNIPLNYVLI-FGKFGLpalggAGAGLATAIVYWLMFLALAFYIRrhkRFRRYRLFARFWRPDWARLKELLRLGLPI 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 267 ALMLCLEfwylMVLVVVTGLLPNPL--IPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSIT 344
Cdd:cd13131 239 GLTIFFE----VSLFAAVALLMGRLgtTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGL 314

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 345 STLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACYYIIGLP 424
Cdd:cd13131 315 GVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLALISYWGIGLP 394

                       410       420
                ....*....|....*....|....
gi 15220246 425 AGLVLGFTLDLGVQGIWGGMVAGI 448
Cdd:cd13131 395 LGYLLAFTTGLGAFGVWIGLIIGL 418
MATE_NorM_like cd13137
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 37-464 2.64e-36

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240542 [Multi-domain]  Cd Length: 432  Bit Score: 139.18  E-value: 2.64e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  37 KRLWELAGPAIFTAISQYSLGALTQTFSGRLGELELAAVSVENSVIsGLAFGVMLGMGSALETLCGQAYGAGQIRMMGIY 116
Cdd:cd13137   1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVL-WLLLVLNMALGTGTVALVSQSYGAGDYERARRA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 117 MQRSWVILFTTALFLLPV-YIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGVV 195
Cdd:cd13137  80 LGQSLLLALLLSLPLALLgLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 196 LVIHAVFSWLFILY----FKWGLVGAAITLNTSWwLIVIGQLLYILITKSDGAWTGFSMLAFR--DLYGFVKLSLASALM 269
Cdd:cd13137 160 NVLNIVLDYVLIFGlwgfPGLGVAGAALATVISR-VVGALLLLFLLLRGRLPIKISFKGFRLDrkIIKKLLRIGLPAGLE 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 270 LCLEFWYLMVLVVVTGLLPNplIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLIG 349
Cdd:cd13137 239 QLLRSLGFLVLLAIVASYGT--AALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFM 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 350 IVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACYYIIGLPAGLVL 429
Cdd:cd13137 317 GLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLL 396

                       410       420       430
                ....*....|....*....|....*....|....*
gi 15220246 430 GFTLDLGVQGIWGGMVAGICLQTLILIGIIYFTNW 464
Cdd:cd13137 397 GFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKW 431
MatE pfam01554
MatE; The MatE domain
 45-205 1.27e-26

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 105.34  E-value: 1.27e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246    45 PAIFTAISQYSLGALTQTFSGRLGELELAAVSVENSvISGLAFGVMLGMGSALETLCGQAYGAGQIRMMGIYMQRSWVIL 124
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANS-IASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246   125 FTTALFL-LPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGVVLVIHAVFS 203
Cdd:pfam01554  80 LLLSLPIaLLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLN 159


                  ..
gi 15220246   204 WL 205
Cdd:pfam01554 160 YL 161
MATE_like_7 cd13133
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 37-464 8.29e-26

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240538 [Multi-domain]  Cd Length: 438  Bit Score: 109.54  E-value: 8.29e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  37 KRLWELAGPAIFTAISQYSLGALTQTFSGRLGELELAAvsvenSVISGLAF--GVMLGMGSA--LETLCGQAYGAGQIRM 112
Cdd:cd13133   5 REILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAA-----SGPAGVLYfaILMLFFGLSsgVQVFVAQYNGAGRYSR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 113 MGIYMQRSWVILFTTALFLLPVYIWAPP-ILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWI 191
Cdd:cd13133  80 IGRVLWQGLYFSLLLAPLLALLSALAAPlLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 192 SGVVLVIHAVFSWLFIL----YFKWGLVGAAITLNTSWWLIVIGQLLYILITKSD-----GAWTGFSMLAFRDLygfVKL 262
Cdd:cd13133 160 NLVMVVVNIVLDYALIFgklgFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRrrfglRRAWRFDRELLRRI---LRL 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 263 SLASALMLCLEFWYLMVLVVVTGLLpnPLIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVS 342
Cdd:cd13133 237 GLPSGLQFFLDVGAFTVFFLLIGRL--GTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGL 314

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 343 ITSTLIGIVCMIVVLATKDSFPYLFT---SSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACYY 419
Cdd:cd13133 315 KLALAYMLLLGILFLLFPELLLSIFTpgaDFALIAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAW 394

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*
gi 15220246 420 IIGLPAGLVLGfTLDLGVQGIWGGMVAGICLQTLILIGIIYFTNW 464
Cdd:cd13133 395 LYLLPPAYLLV-VLGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
PRK01766 PRK01766
multidrug efflux protein; Reviewed
 30-448 5.86e-25

multidrug efflux protein; Reviewed


Pssm-ID: 234981 [Multi-domain]  Cd Length: 456  Bit Score: 107.21  E-value: 5.86e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246   30 KEFGEESKRLWELAGPAIFTAISQYSLGALTQTFSGRLGELELAAVSVENS----VISGLAfGVMLgmgsALETLCGQAY 105
Cdd:PRK01766   5 QKYKSEARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSiwlpVILFGH-GLLL----ALTPIVAQLN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  106 GAGQIRMMG-IYMQRSWVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKF---ALWMIPQLFAYAAnfpIQKFLQS 181
Cdd:PRK01766  80 GAGRRERIAhQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYlhaLLWGIPAYLLYQV---LRSFIDG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  182 QRKVLVMAWISGVVLVIHAVFSWLFIlYFKWGL-----VGAAITLNTSWWLIVIGQLLYILITKSD---GAWTGFSMLAF 253
Cdd:PRK01766 157 LGKTKPTMVIGFLGLLINIPLNYIFI-YGKFGFpelggVGCGVATAIVYWVMFLAMLIYIKRARRFrdfRLFKGLYKPDW 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  254 RDLYGFVKLSLASALMLCLEfwylMVLVVVTGLLPNPL--IPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNA 331
Cdd:PRK01766 236 AVIKRLLKLGLPIGLAIFFE----VSLFAVVTLLVSPLgtVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRT 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  332 ALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVA 411
Cdd:PRK01766 312 LDARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKDTRVIF 391

                        410       420       430
                 ....*....|....*....|....*....|....*..
gi 15220246  412 YVNIACYYIIGLPAGLVLGFTLDLGVQGIWGGMVAGI 448
Cdd:PRK01766 392 FITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGL 428
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 43-460 9.66e-25

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 105.87  E-value: 9.66e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  43 AGPAIFTAISQYSLGALTQTFSGRLGELELAAVSVeNSVISGLAFGVMLGMGSALETLCGQAYGAGQIRMMGIYMQRS-W 121
Cdd:cd12082   1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGL-AFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSiV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 122 VILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGVVLVIHAV 201
Cdd:cd12082  80 LAILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNIL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 202 FSWLFILYF---KWGLVGAAITLNTSWwliVIGQLLYILITKSDGAWTGFSMLAF----RDLYGFVKLSLASALMLCLEF 274
Cdd:cd12082 160 LDPLLIFGLgppELGIAGAALATVISY---VIGALLLLIYLRKGKKILKFKLSLLkpdlELLRRLLRIGLPSAIQNSLLS 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 275 WYLMVLVVVTGLLPNPLIpVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLIGIVCMI 354
Cdd:cd12082 237 LGLLIIVAIVAAFGGAAA-LAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGL 315

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 355 VVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACYYIIGLPAGLVLGFtLD 434
Cdd:cd12082 316 LILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAY-LG 394

                       410       420
                ....*....|....*....|....*.
gi 15220246 435 LGVQGIWGGMVAGICLQTLILIGIIY 460
Cdd:cd12082 395 LGLYGIWLALVISLILAALVLLLFFR 420
MATE_yoeA_like cd13138
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 67-465 8.79e-24

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240543 [Multi-domain]  Cd Length: 431  Bit Score: 103.31  E-value: 8.79e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  67 LGELELAAVSVENSVIsGLAFGVMLGMGSALETLCGQAYGAGQIRMMGIYMQRSWVILFTTALFLLPV-YIWAPPILSFF 145
Cdd:cd13138  34 LGVAALAAVSNGSPII-FLLTAIGMGLSMGGTILISQYIGAKDEEKAKKAVGTLLVLFLILGIVLTILgLLFAPPILRLM 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 146 G---EAPHISKAAGKFALWMIPQLFAYAAnfpIQKFLQSQRKVLVMAWISGVVLVIHAVFSWLFILYFKWGLVGAAITLN 222
Cdd:cd13138 113 NtpaEILELAVSYLRICFLGIPFIFGYNA---YSAILRGLGDSKTPLYFVIIACVLNIILDLLFIAVFHMGVAGAALATV 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 223 TSWWLIVIGQLLYILITKSDGAWTGFSMLAFRDLYG-FVKLSLASALMLCLE---FWYLMVLVVVTGLlpnplIPVDAIS 298
Cdd:cd13138 190 IAQAISVLLALYYLRKKKLPFKLSLKDFRFDKEILKeILKIGLPSALQQSLVsisFLIINSIVNSYGV-----VASAAYG 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 299 ICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETT 378
Cdd:cd13138 265 IANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGA 344

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 379 RIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACYYIIGLPAGLVLGFTLDLGVQGIWGGMVAGICLQTLILIGI 458
Cdd:cd13138 345 EYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIY 424


                ....*..
gi 15220246 459 IYFTNWN 465
Cdd:cd13138 425 YRKGRWK 431
MATE_MepA_like cd13143
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
 39-441 4.71e-22

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.


Pssm-ID: 240548 [Multi-domain]  Cd Length: 426  Bit Score: 98.35  E-value: 4.71e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  39 LWELAGPAIFTAISQYSLGALTQTFSGRL-GELELAAVSVENSVISGL-AFGVMLGMGSAleTLCGQAYGAGQIRMMGIY 116
Cdd:cd13143   6 FLKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMLLmALGLMIGVGGA--SLISRRLGAGDREKANRI 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 117 MQRS-WVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGVV 195
Cdd:cd13143  84 FSTAlLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIG 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 196 LVIHAVFSWLFILYFKWGLVGAAITLNTSWwliVIGQLLYILITKSDGAWTGFSM----LAFRDLYGFVKLSLASALMlc 271
Cdd:cd13143 164 AVLNIILDPLFIFVLGLGIAGAALATVIAQ---LISLLLLLLYFFRGKSLLKLSLlrfkLSLKIIKEILALGFPSFLM-- 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 272 leFWYLMVLVVVTGLLPNPL---IPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLI 348
Cdd:cd13143 239 --QLSSSVVTIVLNLTLLGYggdIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIY 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 349 GIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSG--VAVGAGWQALVayvnIACYYIIGLPAG 426
Cdd:cd13143 317 GLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGyfQAIGKAKRAAL----LSLLRQGLFLIP 392

                       410
                ....*....|....*
gi 15220246 427 LVLGFTLDLGVQGIW 441
Cdd:cd13143 393 LLLILPRLFGLDGIW 407
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 36-456 1.54e-21

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 96.80  E-value: 1.54e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  36 SKRLWELAGPAIFTAISQYSLGALTQTFSGRLGELELAAVSVENSVIsGLAFGVMLGMGSALETLCGQAYGAG------Q 109
Cdd:cd13134   2 KLSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQIL-FLLILIFSFISTGTSILIAQYLGAKdkkkarQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 110 IRMMGIYMqrswVILFTTALFLLpVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMA 189
Cdd:cd13134  81 IAGVALLF----NLLLGLVFSLL-LLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPM 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 190 WISGVVLVIHAVFSWLFILYF----KWGLVGAAITLNTSWWLIVIGQLLYILITKSDGAWT-GFSMLAFRDLYGFVKLSL 264
Cdd:cd13134 156 YVSLIMNILNIVGNYLLIFGWfglpKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLkDLRPFPKKLLKKILKIGL 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 265 ASAL-MLCLEFWYLMVLVVVTGLLPNPLIpvdAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSI 343
Cdd:cd13134 236 PSAGeELSYNLSQTVITAFIARLGTAALA---ARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLK 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 344 TSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACYYIIGL 423
Cdd:cd13134 313 IGLLVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISV 392

                       410       420       430
                ....*....|....*....|....*....|...
gi 15220246 424 PAGLVLGFTLDLGVQGIWGGMVAGICLQTLILI 456
Cdd:cd13134 393 PLAYLLGIVLGLGLLGVWIAFAADEWVRGIIML 425
MATE_DinF_like cd13136
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ...
 37-460 1.16e-19

DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240541 [Multi-domain]  Cd Length: 424  Bit Score: 91.08  E-value: 1.16e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  37 KRLWELAGPAIFTAISQYSLGALTQTFSGRLGEL-ELAAVSVENSVISGLAFGVM-LGMGSAleTLCGQAYGAGQ-IRMM 113
Cdd:cd13136   3 REILALALPAILSNITVPLLGLVDTAVVGHLGSAaYLGAVALGTTIFNTLFWLFGfLRMGTT--GLVAQALGAGDrEEAI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 114 GIYMQRSWVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISG 193
Cdd:cd13136  81 ALLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 194 VVLVIHAVFSWLFILYFKWGLVGAAITLNTSWWLIVIGQLLYILITKSDGAWTGFSML-AFRDLYGFVKLSLASAL-MLC 271
Cdd:cd13136 161 VGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLpSKAALKRLFKLNRDIFIrTLA 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 272 LEFWYLMVLVVVTGLLPNPLIpvdAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLIGIV 351
Cdd:cd13136 241 LLAAFLFFTALAARLGDVILA---ANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLGVL 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 352 CMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACyYIIGLPAGLVLGF 431
Cdd:cd13136 318 LALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVS-LAVFLPLLFLLVP 396

                       410       420
                ....*....|....*....|....*....
gi 15220246 432 TldLGVQGIWGGMVAGICLQTLILIGIIY 460
Cdd:cd13136 397 L--WGNHGLWLALILFMLLRGLTLALRLP 423
MatE pfam01554
MatE; The MatE domain
 266-424 4.65e-19

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 84.15  E-value: 4.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246   266 SALMLCLEFWYLMVLVVVTGLLPnpLIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITS 345
Cdd:pfam01554   2 IALENLLQSLYSLIDTLFVGHLG--AVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15220246   346 TLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACyYIIGLP 424
Cdd:pfam01554  80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIP 157
MATE_like_12 cd13142
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 37-466 6.34e-17

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240547 [Multi-domain]  Cd Length: 444  Bit Score: 83.01  E-value: 6.34e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  37 KRLWELAGPAIFTAISQySLGALTQTF-SGRLGELELAAVSVENSVIsGLAFGVMLGMGSALETLCGQAYGAGQIRMMGI 115
Cdd:cd13142  11 RTLLKLAWPIIVSNLLQ-VAYNLADTFwLGRLGADAVAAPSISWPLI-FLFISLGGGLTVAGTALVAQYTGAGDYDKANK 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 116 YMQR--SWVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWM---IPQLFAYaanFPIQKFLQSQRKVLVMAW 190
Cdd:cd13142  89 VAGQtfSFVIILSLILAVLGYILSRPLLLLLIGAPEEVYPLALAYLRIIflgLPFMFIF---FVFNSLLRGIGDTKTPMK 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 191 ISGVVLVIHAVFSWLFILYF----KWGLVGAAITLNTSWwLIVIGQLLYILITKSDGAWTGFSMLAF-RDLYG-FVKLSL 264
Cdd:cd13142 166 IMFGSVLLNVILDPLLIFGIgpfpGLGVAGAALATVISR-GIAAVIGLYLLFKGRVGLKISLRDLKPdWEWLKkIFRIGL 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 265 ASALMLCLEFWYLMVLVVVTGLLPNPLipVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSIT 344
Cdd:cd13142 245 PSSIEQSARALGFTVMTALVAGFGTVV--VAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALL 322

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 345 STLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACYYIIGLP 424
Cdd:cd13142 323 IFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIP 402

                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 15220246 425 AGLVLGFTLDLGVQGIWGGMVAGICLQTLILIGIIYFTNWNK 466
Cdd:cd13142 403 LAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTWKK 444
MATE_like_1 cd13140
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 33-441 1.33e-16

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240545 [Multi-domain]  Cd Length: 435  Bit Score: 81.80  E-value: 1.33e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  33 GEESKRLWELAGPAIFTAISQYSLGALTQTFSGRLGELELAAVSVeNSVISGLAFGVMLGMGSALETLCGQAYGAGQIRM 112
Cdd:cd13140   1 GPILKTLLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGT-AGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 113 MGIYMQRS-WVILFTTALFLLPVYIWAPPILSFFG-EAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAW 190
Cdd:cd13140  80 ARKYARNAlQLNLLLGILYGLLLLLFAKPLIGFFNlGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 191 ISGVVLVIHAVFSWLFILYF----KWGLVGAAITLNTSWWLIVIGQLLYIL-ITKSDGAWTGFSMLAFRDLYGFVKLSLA 265
Cdd:cd13140 160 INAIGLVLNIILDPLLIFGFgpfpALGVAGAALATVLAQAIVFLLFLYALKkKKGLFLKIRILKRPDRKYIKEILKLGLP 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 266 SALMLCL-EFWYLMVLVVVTGLLPnplIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSIT 344
Cdd:cd13140 240 VALQSILfALISMILARIIASFGP---VAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKI 316

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 345 STLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACYYiIGLP 424
Cdd:cd13140 317 ASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISIVFNG-LRIP 395

                       410
                ....*....|....*..
gi 15220246 425 AGLVLGFTLdLGVQGIW 441
Cdd:cd13140 396 LALLLSPTG-LGLNGIW 411
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
37-235 1.69e-15

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 78.26  E-value: 1.69e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  37 KRLWELAGPAIFTAISQYSLGALTQTFSGRLGELELAAVSVENSVISgLAFGVMLGMGSALETLCGQAYGAGQIRMMGIY 116
Cdd:COG0534 229 KRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIES-LAFMPALGLGQAAQPLVGQNLGAGDYDRARRA 307

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 117 MQRS--WVILFTTALFLLpVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGV 194
Cdd:COG0534 308 ARLAllLALGIGLLLALL-LFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLL 386

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 15220246 195 VLVIHAVFSWLFILYFKWGLVGAAITLNTSWWLIVIGQLLY 235
Cdd:COG0534 387 RLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
MATE_like_9 cd13135
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 37-457 9.43e-11

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240540 [Multi-domain]  Cd Length: 429  Bit Score: 63.47  E-value: 9.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  37 KRLWELAGPAIFTAISQYSLGALTQTFSGRLGELELAAVSVENSVISGLAfGVMLGMGSALETLCGQAYGAGQIRMMGIY 116
Cdd:cd13135   1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTIT-GFLGSISIGFTILGSQSVGAKDIKRINDY 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 117 MQRSWV--ILFTTALFLLpVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQ--SQRKVLVMAWIS 192
Cdd:cd13135  80 AISSIVynSIIGVILFLL-WLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQgiGETKPIMYGGII 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 193 GVVLVIhaVFSWLFIL----YFKWGLVGAAITLNTSWWLIVIgqLLYILITKSDGAWTGFSM-----LAFRDLYGFVKLS 263
Cdd:cd13135 159 KNLLNV--ILDYVLIFgnfgFPRLGIIGAAIATTIANVLNLI--ILVYLCRKIKKLTFKLSNtkvlkANIRPYKFTIKLG 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 264 LASALMLCLefWYLMVLVVVTGLLPNPLIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSI 343
Cdd:cd13135 235 LPLGGEEFL--WNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLG 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 344 TSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACYYIIGL 423
Cdd:cd13135 313 LGLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIGTIIVVS 392

                       410       420       430
                ....*....|....*....|....*....|....
gi 15220246 424 PAgLVLGFTLDLGVQGIWGGMVAGICLQTLILIG 457
Cdd:cd13135 393 VA-LLLIFVFKLGLAGVYITLFIDEIIRAIINFL 425
MATE_like_14 cd13139
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 63-461 2.52e-10

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240544 [Multi-domain]  Cd Length: 448  Bit Score: 62.24  E-value: 2.52e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  63 FSGRLGELELAAVSVENSVISgLAFGVMLGMGSALETLCGQAYGAGQIRMMGI-YMQRSWVILFTTALFLLPVYIWAPPI 141
Cdd:cd13139  40 FVSRLGALAIATVGLTESVLT-IVYSIAIGLSMAATALVARRIGEKDPEGAGFaAVQAILLGVALSLILSILGYFFAEDI 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 142 LSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQS------QRKVLVMAWISGVVLVIHAVFSWLFILyfKWGLV 215
Cdd:cd13139 119 LSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGagdaaiAMRSLWLANGLNIILDPLFIFGLGPIP--AMGVT 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 216 GAAITLNTSWWLIVIGQLlYILITKSDGAWTGFSMLAFR----------DLYGFVKLSLASALMLclefwYLMVLVVVTG 285
Cdd:cd13139 197 GAAIATTIGRSIGVLYQL-YHLFKGKGRIQIRRRHLKLDwaiikkiikiAVGGILQFLIASSSWI-----FLVRIIAEFG 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 286 LlpnplIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSV-IVVSITSTLIGIVCmIVVLATKDSFP 364
Cdd:cd13139 271 S-----TALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVwRAGKYNMVFLGIVS-LVFFLFAEPLV 344

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 365 YLFTSSEAV---AAETTRIaVLLGFTVLLNSLqpVLSGVAVGAGWQALVAYVNIACYYIIGLPAGLVLGFTLDLGVQGIW 441
Cdd:cd13139 345 SFFTTDPEViaiAVEALRI-ISLGYIFYGYGM--VLSQAFNGAGDTKTPTLINLVGFWLFQIPLAYLLARHLNLGPKGVF 421

                       410       420
                ....*....|....*....|
gi 15220246 442 GGMVagICLQTLILIGIIYF 461
Cdd:cd13139 422 IAIP--IAETVLAIAAIILF 439
MATE_like_4 cd13144
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 36-441 1.78e-08

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240549 [Multi-domain]  Cd Length: 434  Bit Score: 56.47  E-value: 1.78e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  36 SKRLWELAGPAIFTAISQYSLGALTQTFSGRLGELELAAVSVENSVISgLAFGVMLGMGSALETLCGQAYGAGQIRMM-- 113
Cdd:cd13144   7 LRLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQN-LMIAVAVGTGVGVNALLSRSLGEKDQKEAnk 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 114 ----GIYMqrswvILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMA 189
Cdd:cd13144  86 aannGLLL-----ALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPM 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 190 WISGVVLVIHAVFSWLFILYF----KWGLVGAAITlntswwlIVIGQ------LLYILITKS-----DGAWTGFSMLAFR 254
Cdd:cd13144 161 IAQLIGAIINIILDPILIFGLfgfpAMGIAGAAIA-------TVIGQilamflAFFFLLRKNkdvqpDLRLFRPSLRIIK 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 255 DLYgfvKLSLASALMLCLEfwYLMVLVVVTGLLPNPLIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALA 334
Cdd:cd13144 234 EIY---AVGLPSIIMQAIS--SVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRI 308

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 335 KFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVN 414
Cdd:cd13144 309 REAIKYAILIAVVIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIIS 388

                       410       420
                ....*....|....*....|....*..
gi 15220246 415 IACYYIIGLPAGLVLGFTldLGVQGIW 441
Cdd:cd13144 389 VARQLVVLLPLAWLLAKM--FGLNGVW 413
PRK00187 PRK00187
NorM family multidrug efflux MATE transporter;
35-448 3.49e-07

NorM family multidrug efflux MATE transporter;


Pssm-ID: 166843 [Multi-domain]  Cd Length: 464  Bit Score: 52.44  E-value: 3.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246   35 ESKRLWELAGPAIFTAISqYSLGALTQTFS-GRLGELELAAVSVENSVISGLAFgVMLGMGSALETLCGQAYGAGQIRMM 113
Cdd:PRK00187   8 ELKAILRLAGPLIASQLA-HMLMVFTDTLMmGRLGPEALAGGGLGAASYSFVSI-FCVGVIAAVGTLVAIRHGAGDIEGA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  114 GIYMQRSWVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQS-QRKVLVMAwIS 192
Cdd:PRK00187  86 TRLAQAGLWLAWLLALVAALLLWNLKPLLLLFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSAlGRAGPVMV-IS 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  193 GVVLVIHAVFSWLFILYF----KWGLVGAAITLNTSWWLIVIGQLLYILITKSDGAW---TGFSMLAFRDLYGFVKLSLA 265
Cdd:PRK00187 165 LAGAVANLLLNYALIEGWfglpKLGLMGIGLVTALVSNGMALALALYIRRHPAYAAYplrKGLSRPSRAALRELWRLGLP 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  266 SALMLCLEFWYLMVLVVVTGLLPNplIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIV-VSIT 344
Cdd:PRK00187 245 IGGTYAVEVGLFTFAALCMGALGS--TQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVgIGFG 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  345 STLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAV-LLGFTV---LLNSLQPVLSGVAVGAGWQALVAYVNIACYYI 420
Cdd:PRK00187 323 AVVMLLFAGLFWLLPEAIIGLFLDRNDPAFAEIVQLAVsLLAVAAwfeLFDGTQTIAMGAIRGLKDARTTFLIGLACYWL 402

                        410       420
                 ....*....|....*....|....*...
gi 15220246  421 IGLPAGLVLGFTLDLGVQGIWGGMVAGI 448
Cdd:PRK00187 403 VGAPLAWLLAFTLGWGAVGVWWGLALGL 430
MATE_like_6 cd13146
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 85-447 1.12e-04

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240551 [Multi-domain]  Cd Length: 433  Bit Score: 44.31  E-value: 1.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  85 LAFGVMLGMGSALETLCG--QAYGAGQIRMMGIYMQrswviLFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWM 162
Cdd:cd13146  62 LGNGIQVGVSSLLARAIGaqRAKELDQAADSGLALA-----LLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYS 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 163 IPQLFAYAANFPIQKFLQSQRKVLVMAWISGVVLVIHAVFSWLFILYFKWGLVGAAITLNTSwWLIVIGQLLYILITKSD 242
Cdd:cd13146 137 LPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLDPILIFVFDMGVKGAALATVLA-QAISLLYLLYVFLIGKS 215

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 243 GAWT--GFSMLAFRDLYGFVKLSLASALM-LCLEFWYLMVLVVVTGLLPNPLipvDAISICMNIEGWTAMISIGFNAAIS 319
Cdd:cd13146 216 NVTIhiKLSNISSSVIVEILRVGLPQMLLqLISSISFLIYNRIIIDIDPVAM---TAFTLVGRLDQFILIPIFAISSALL 292

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 320 VRVSNELGAGNAALAKFSVIVVSITSTLI-GIVCMIVVLATKDSFPYLFTSSEAV--AAETTRIaVLLGFTVLLNSLQPV 396
Cdd:cd13146 293 TIAGQNWGRGNYDRMLQILMTAVILGIVVvLVLVLGYVLVAPWLFSLFTTVPEVVayAVLQVRT-MALALPFVAISILVT 371

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 15220246 397 LSGVAVGAGWQALVayVNIACYYIIGLPAGLVLGFTLDLGVQGIWGGMVAG 447
Cdd:cd13146 372 EFFQAIGKAWPSLL--LTLIRHVFLSVPVVYLLAYVFGKGITGVYFGIVSA 420
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 296-466 1.50e-04

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 44.24  E-value: 1.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 296 AISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAA 375
Cdd:cd12082  32 AVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLAILLGLLLAALLLFFSPLILSLLGAEEEVIE 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 376 ETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACyYIIGLPAGLVLGFTLDLGVQGIWGGMVAGICLQTLIL 455
Cdd:cd12082 112 LAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLS-NLLNILLDPLLIFGLGPPELGIAGAALATVISYVIGA 190

                       170
                ....*....|.
gi 15220246 456 IGIIYFTNWNK 466
Cdd:cd12082 191 LLLLIYLRKGK 201
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 309-461 1.60e-04

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 44.03  E-value: 1.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 309 MISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTV 388
Cdd:cd13134  53 LIFSFISTGTSILIAQYLGAKDKKKARQIAGVALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSL 132

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15220246 389 LLNSLQPVLSGVAVGAGWQALVAYVNIACYYI-IGLPAGLVLGF--TLDLGVQGIWGGMVAGICLQTLILIGIIYF 461
Cdd:cd13134 133 FLQALSLTLSAILRSHGRTKIPMYVSLIMNILnIVGNYLLIFGWfgLPKLGVAGVAISTVISRAVGLVLLFILLFR 208
MATE_like_5 cd13145
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 91-237 2.32e-04

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240550 [Multi-domain]  Cd Length: 440  Bit Score: 43.36  E-value: 2.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  91 LGMGSALETLCGQAYGAGQI-RMMGIYMqRSWVILFTTALFL-LPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFA 168
Cdd:cd13145 287 IGLNTAVLSIAGQNFGAKKYdRVRETYK-KALKYGFVIMVVAtVFLLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYA 365

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 169 YAANFPIQKFLQSQRKVLVMAWISGV-VLVIHAVFSWLFILYFKWGLVGAAITLNTSWWLIVIGQLLYIL 237
Cdd:cd13145 366 YVVLFISVSVLQGLKRPIFALWIGLYrQLVGPALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIALLYTR 435
MATE_like_5 cd13145
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 63-456 3.00e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240550 [Multi-domain]  Cd Length: 440  Bit Score: 39.89  E-value: 3.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  63 FSGRLGELELAAVSVENSV-ISGLAFGVmlGMGSALETLCGQAYGAGQIRMMGIYMQRSWVILFTTALFLLPV-YIWAPP 140
Cdd:cd13145  35 FAGKISTEALAALSLSFPIfFIIIAIGV--GIGTGTTALIGNALGAGDRRKARRYAAQGLSFGIILAILLTVIgLFAAPP 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 141 ILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQ------RKVLVMAWISGVVLVIHAVFSWLFIlyFKWGL 214
Cdd:cd13145 113 LFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQgdtksyRNFLIIGFFLNIILDPLFIFGGGGI--PAMGV 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 215 VGAAItlntSWWLIVIGQLLYIL--ITKSdGAWTGFSMLAF---RDLY-GFVKLSLASAL-MLCLEFWYLMVLVVVTGLL 287
Cdd:cd13145 191 SGIAL----ATIISQFIGMFYLLykVRKS-GIISGCRLRDFiprLDVYkEILKQGFPASLnMMTIGLGIFVITYFVGQFG 265

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 288 PnplIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGnaalaKFSVIV-VSITSTLIGIVCMIV----VLATKDS 362
Cdd:cd13145 266 D---EAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAK-----KYDRVReTYKKALKYGFVIMVVatvfLLFFAEP 337

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 363 FPYLFTSSEAV---AAETTRIAVLLGFT-VLLNSLQPVLSGVAvgagwQALVAyVNIACYYIIGLPAGL--VLGFTLDLG 436
Cdd:cd13145 338 LMSLFTNDPAViaiGAGYLRIDALIFYAyVVLFISVSVLQGLK-----RPIFA-LWIGLYRQLVGPALVfwLLVNVLGLG 411

                       410       420
                ....*....|....*....|
gi 15220246 437 VQGIWGGMVAGICLQTLILI 456
Cdd:cd13145 412 VTGIWWGIFTIVWSAAIIAL 431
MurJ COG0728
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ...
 124-269 6.84e-03

Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440492 [Multi-domain]  Cd Length: 503  Bit Score: 38.98  E-value: 6.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246 124 LFTTALFLLPV----YIWAPPILSFFGEAPHISKAAGKFA----LWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGVV 195
Cdd:COG0728 306 LRLVLLLTLPAavglIVLAEPIVRLLFERGAFTAEDTALTalalAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIA 385

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15220246 196 LVIHAVFSWLFILYFKWGLVGAAITLntSWWLIVIgqLLYILITKSDGAWTGFSMLAFrdlygFVKLSLASALM 269
Cdd:COG0728 386 VVVNIVLNLLLVPPLGHAGLALATSL--SALVNAL--LLLVLLRRRLGGLPLRGILRT-----LLKLLLASLVM 450
RfbX COG2244
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ...
 82-233 8.89e-03

Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441845 [Multi-domain]  Cd Length: 366  Bit Score: 38.39  E-value: 8.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15220246  82 ISGLAFGVMLGMGSALETLCGQAYGAGQI-RMMGIYMQRSWVILFTTALFLLPVYIWAPPILSF-FGEAPHiskAAGKFA 159
Cdd:COG2244 218 LASLLLLLITALSQVLFPRLSRLLAEGDReELRRLYRKALRLLLLLGLPLALGLALLAPPLLSLlFGPEYA---EAAPVL 294

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 15220246 160 LWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGVVLVIHAVFSWLFILYfkWGLVGAAITLNTSWWLIVIGQL 233
Cdd:COG2244 295 PILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNLVLNLLLIPR--YGLVGAAIATLLSYLVLLLLLL 366
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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