NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|15218190|ref|NP_172998|]
View 

periodic tryptophan protein 2 [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11456769)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
303-660 1.92e-58

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 205.53  E-value: 1.92e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 303 ASAKVTACDYHQGLDMVVVGFSNGVFGLYQMPDFICIHLLSISRQKLTTAVFNERGNWLTFGCAkLGQLLVWDWRTETYI 382
Cdd:COG2319  35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA-DGTVRLWDLATGLLL 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 383 LKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWDFKR 462
Cdd:COG2319 114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 463 YKNYKTYTTPTPRqFVSLTADPSGDVVCAGTLDSfEIFVWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVR 542
Cdd:COG2319 194 GKLLRTLTGHTGA-VRSVAFSPDGKLLASGSADG-TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 543 LWDVfASKGTVETFR-HNHDVLTVAFRPDGKQLASSTLDGQINFWDTIEGVLMYTIEGRRDIAggrvmtdrrsaansssg 621
Cdd:COG2319 272 LWDL-ATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV----------------- 333

                       330       340       350
                ....*....|....*....|....*....|....*....
gi 15218190 622 kcfTTLCYSADGGYILAAGTSRYICMYDIADQVLLRRFQ 660
Cdd:COG2319 334 ---RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
WD40 COG2319
WD40 repeat [General function prediction only];
32-546 1.24e-30

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.41  E-value: 1.24e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190  32 NRVSVTDLSKNHSVTLPLETSTNICRLASSPDGTFLLAVDEQNRCLFINLPRRVVLHRIT-FKDKVGALKFSPNGKFIAV 110
Cdd:COG2319 100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGKLLAS 179

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 111 G-IGKLVEIWRspgfrraVLPFERVRTFANSDDKVVSLEWSLDSDYLLVGSRDLAARLFCVRKLKGVlnkpFLFLGHRDS 189
Cdd:COG2319 180 GsDDGTVRLWD-------LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL----RTLTGHSGS 248

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 190 VvgcffgvdkmtnkvnraFTIArdgyiFSwgytekdvkmdesedghseppspvtPDradevmvengggvgtelkkrkeyd 269
Cdd:COG2319 249 V-----------------RSVA-----FS-------------------------PD------------------------ 257

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 270 gkglesdeegddddeeymhrGKWVllrkdgcnqASAkvtacdyhqGLDmvvvgfsngvfglyqmpdficihllsisrqkl 349
Cdd:COG2319 258 --------------------GRLL---------ASG---------SAD-------------------------------- 267

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 350 ttavfnergnwltfgcaklGQLLVWDWRTETYILKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTE 429
Cdd:COG2319 268 -------------------GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 430 HTNAVTALHFMADNHSLLSASLDGTVRAWDFkryknyktyttptprqfvsltadpsgdvvcagtldsfeifvwskKTGQI 509
Cdd:COG2319 329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWDL--------------------------------------------ATGEL 364

                       490       500       510
                ....*....|....*....|....*....|....*..
gi 15218190 510 KDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRLWDV 546
Cdd:COG2319 365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 790-895 3.67e-26

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


:

Pssm-ID: 461125  Cd Length: 106  Bit Score: 103.40  E-value: 3.67e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190   790 NEDSLIKKCIFAVAPADIKAVAISVRQKYLERLMEALVDLL-ENCPHLEFILHWCQEICKAHGSSIQRNyRTLLPALRSL 868
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLaERSPHLELLLRWLKFLLRTHGGYLVSN-PDLRPVLRSL 79

                          90       100
                  ....*....|....*....|....*..
gi 15218190   869 QKAITRAHQDLADMCSSNEYTLRYLCS 895
Cdd:pfam04003  80 QKLLRRRLKELKDLLGLNLGALDYLLS 106
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
303-660 1.92e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 205.53  E-value: 1.92e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 303 ASAKVTACDYHQGLDMVVVGFSNGVFGLYQMPDFICIHLLSISRQKLTTAVFNERGNWLTFGCAkLGQLLVWDWRTETYI 382
Cdd:COG2319  35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA-DGTVRLWDLATGLLL 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 383 LKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWDFKR 462
Cdd:COG2319 114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 463 YKNYKTYTTPTPRqFVSLTADPSGDVVCAGTLDSfEIFVWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVR 542
Cdd:COG2319 194 GKLLRTLTGHTGA-VRSVAFSPDGKLLASGSADG-TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 543 LWDVfASKGTVETFR-HNHDVLTVAFRPDGKQLASSTLDGQINFWDTIEGVLMYTIEGRRDIAggrvmtdrrsaansssg 621
Cdd:COG2319 272 LWDL-ATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV----------------- 333

                       330       340       350
                ....*....|....*....|....*....|....*....
gi 15218190 622 kcfTTLCYSADGGYILAAGTSRYICMYDIADQVLLRRFQ 660
Cdd:COG2319 334 ---RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 338-599 2.53e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 187.54  E-value: 2.53e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 338 CIHLLSISRQKLTTAVFNERGNWLTFGCAkLGQLLVWDWRTETYILKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWN 417
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSG-DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 418 VMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWDFKRYKnyKTYTTPTPRQFV-SLTADPSGDVVCAGTLDS 496
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGHTDWVnSVAFSPDGTFVASSSQDG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 497 FeIFVWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRLWDVFASKgTVETFR-HNHDVLTVAFRPDGKQLA 575
Cdd:cd00200 158 T-IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK-CLGTLRgHENGVNSVAFSPDGYLLA 235

                       250       260
                ....*....|....*....|....
gi 15218190 576 SSTLDGQINFWDTIEGVLMYTIEG 599
Cdd:cd00200 236 SGSEDGTIRVWDLRTGECVQTLSG 259
WD40 COG2319
WD40 repeat [General function prediction only];
32-546 1.24e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.41  E-value: 1.24e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190  32 NRVSVTDLSKNHSVTLPLETSTNICRLASSPDGTFLLAVDEQNRCLFINLPRRVVLHRIT-FKDKVGALKFSPNGKFIAV 110
Cdd:COG2319 100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGKLLAS 179

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 111 G-IGKLVEIWRspgfrraVLPFERVRTFANSDDKVVSLEWSLDSDYLLVGSRDLAARLFCVRKLKGVlnkpFLFLGHRDS 189
Cdd:COG2319 180 GsDDGTVRLWD-------LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL----RTLTGHSGS 248

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 190 VvgcffgvdkmtnkvnraFTIArdgyiFSwgytekdvkmdesedghseppspvtPDradevmvengggvgtelkkrkeyd 269
Cdd:COG2319 249 V-----------------RSVA-----FS-------------------------PD------------------------ 257

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 270 gkglesdeegddddeeymhrGKWVllrkdgcnqASAkvtacdyhqGLDmvvvgfsngvfglyqmpdficihllsisrqkl 349
Cdd:COG2319 258 --------------------GRLL---------ASG---------SAD-------------------------------- 267

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 350 ttavfnergnwltfgcaklGQLLVWDWRTETYILKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTE 429
Cdd:COG2319 268 -------------------GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 430 HTNAVTALHFMADNHSLLSASLDGTVRAWDFkryknyktyttptprqfvsltadpsgdvvcagtldsfeifvwskKTGQI 509
Cdd:COG2319 329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWDL--------------------------------------------ATGEL 364

                       490       500       510
                ....*....|....*....|....*....|....*..
gi 15218190 510 KDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRLWDV 546
Cdd:COG2319 365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 790-895 3.67e-26

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 103.40  E-value: 3.67e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190   790 NEDSLIKKCIFAVAPADIKAVAISVRQKYLERLMEALVDLL-ENCPHLEFILHWCQEICKAHGSSIQRNyRTLLPALRSL 868
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLaERSPHLELLLRWLKFLLRTHGGYLVSN-PDLRPVLRSL 79

                          90       100
                  ....*....|....*....|....*..
gi 15218190   869 QKAITRAHQDLADMCSSNEYTLRYLCS 895
Cdd:pfam04003  80 QKLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 93-459 7.51e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.49  E-value: 7.51e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190  93 KDKVGALKFSPNGKFIAVGIG-KLVEIWRSPGFrravlpfERVRTFANSDDKVVSLEWSLDSDYLLVGSRDLAARLF--- 168
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGdGTIKVWDLETG-------ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWdle 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 169 ---CVRKLKGvlnkpflflgHRDSVVGCFFgvdkmtnkvnraftiARDGYIFSWGYTEKDVKMDESEDGhseppspvtpd 245
Cdd:cd00200  82 tgeCVRTLTG----------HTSYVSSVAF---------------SPDGRILSSSSRDKTIKVWDVETG----------- 125

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 246 radevmvengggvgtelKKRKEYDGkglesdeegddddeeymHRGkWVllrkdgcnqasakvTACDYHQGLDMVVVGFSN 325
Cdd:cd00200 126 -----------------KCLTTLRG-----------------HTD-WV--------------NSVAFSPDGTFVASSSQD 156

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 326 GVFGLYQMPDFICIHLLSISRQKLTTAVFNERGNWLTFGCAKlGQLLVWDWRTETYILKQQGHYFDVNCVTYSPDSQLLA 405
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 15218190 406 TGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWD 459
Cdd:cd00200 236 SGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 506-545 5.92e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 5.92e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15218190    506 TGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRLWD 545
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
386-417 6.96e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 6.96e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 15218190   386 QGHYFDVNCVTYSPDSQLLATGADDNKVKVWN 417
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 404-559 4.47e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.92  E-value: 4.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190  404 LATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLL-SASLDGTVRAWDFKRYKNYKTYTTPTPRQFVSLTA 482
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15218190  483 DpSGDVVCAGTLDSfEIFVWSKKTGQIK-DILSGHEAPVHGLMFSPlTQLLASSSWDYTVRLWDV-FASKGTVETFRHN 559
Cdd:PLN00181 628 E-SGRSLAFGSADH-KVYYYDLRNPKLPlCTMIGHSKTVSYVRFVD-SSTLVSSSTDNTLKLWDLsMSISGINETPLHS 703
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
303-660 1.92e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 205.53  E-value: 1.92e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 303 ASAKVTACDYHQGLDMVVVGFSNGVFGLYQMPDFICIHLLSISRQKLTTAVFNERGNWLTFGCAkLGQLLVWDWRTETYI 382
Cdd:COG2319  35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA-DGTVRLWDLATGLLL 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 383 LKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWDFKR 462
Cdd:COG2319 114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 463 YKNYKTYTTPTPRqFVSLTADPSGDVVCAGTLDSfEIFVWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVR 542
Cdd:COG2319 194 GKLLRTLTGHTGA-VRSVAFSPDGKLLASGSADG-TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 543 LWDVfASKGTVETFR-HNHDVLTVAFRPDGKQLASSTLDGQINFWDTIEGVLMYTIEGRRDIAggrvmtdrrsaansssg 621
Cdd:COG2319 272 LWDL-ATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV----------------- 333

                       330       340       350
                ....*....|....*....|....*....|....*....
gi 15218190 622 kcfTTLCYSADGGYILAAGTSRYICMYDIADQVLLRRFQ 660
Cdd:COG2319 334 ---RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
WD40 COG2319
WD40 repeat [General function prediction only];
304-652 1.47e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 197.44  E-value: 1.47e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 304 SAKVTACDYHQGLDMVVVGFSNGVFGLYQMPDFICIHLLSISRQKLTTAVFNERGNWLTFGCAKlGQLLVWDWRTETYIL 383
Cdd:COG2319  78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAD-GTVRLWDLATGKLLR 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 384 KQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWDFKRY 463
Cdd:COG2319 157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 464 KNYKTYTTPTPRqFVSLTADPSGDVVCAGTLDSfEIFVWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRL 543
Cdd:COG2319 237 KLLRTLTGHSGS-VRSVAFSPDGRLLASGSADG-TVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRL 314

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 544 WDVfASKGTVETFR-HNHDVLTVAFRPDGKQLASSTLDGQINFWDTIEGVLMYTIEGRRDIAggrvmtdrrsaansssgk 622
Cdd:COG2319 315 WDL-ATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV------------------ 375

                       330       340       350
                ....*....|....*....|....*....|
gi 15218190 623 cfTTLCYSADGGYILAAGTSRYICMYDIAD 652
Cdd:COG2319 376 --TSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 338-599 2.53e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 187.54  E-value: 2.53e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 338 CIHLLSISRQKLTTAVFNERGNWLTFGCAkLGQLLVWDWRTETYILKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWN 417
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSG-DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 418 VMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWDFKRYKnyKTYTTPTPRQFV-SLTADPSGDVVCAGTLDS 496
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGHTDWVnSVAFSPDGTFVASSSQDG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 497 FeIFVWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRLWDVFASKgTVETFR-HNHDVLTVAFRPDGKQLA 575
Cdd:cd00200 158 T-IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK-CLGTLRgHENGVNSVAFSPDGYLLA 235

                       250       260
                ....*....|....*....|....
gi 15218190 576 SSTLDGQINFWDTIEGVLMYTIEG 599
Cdd:cd00200 236 SGSEDGTIRVWDLRTGECVQTLSG 259
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 304-587 8.26e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 180.61  E-value: 8.26e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 304 SAKVTACDYHQGLDMVVVGFSNGVFGLYQMPDFICIHLLSISRQKLTTAVFNERGNWLtFGCAKLGQLLVWDWRTETYIL 383
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYL-ASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 384 KQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWDFKRY 463
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 464 KNYKTYTTPTpRQFVSLTADPSGDVVCAGTLDSfEIFVWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRL 543
Cdd:cd00200 168 KCVATLTGHT-GEVNSVAFSPDGEKLLSSSSDG-TIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV 245

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 15218190 544 WDVfASKGTVETFR-HNHDVLTVAFRPDGKQLASSTLDGQINFWD 587
Cdd:cd00200 246 WDL-RTGECVQTLSgHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 386-679 4.08e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 158.65  E-value: 4.08e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 386 QGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRawdfkrykn 465
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIR--------- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 466 yktyttptprqfvsltadpsgdvvcagtldsfeifVWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRLWD 545
Cdd:cd00200  77 -----------------------------------LWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 546 VFASKGTVETFRHNHDVLTVAFRPDGKQLASSTLDGQINFWDTIEGVLMYTIEGRRDiaggrvmtdrrsaansssgkCFT 625
Cdd:cd00200 122 VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG--------------------EVN 181

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 15218190 626 TLCYSADGGYILAAGTSRYICMYDIADQVLLRRFQiSHNLSLDGVlDFLHSKKM 679
Cdd:cd00200 182 SVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLR-GHENGVNSV-AFSPDGYL 233
WD40 COG2319
WD40 repeat [General function prediction only];
371-660 1.30e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.68  E-value: 1.30e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 371 LLVWDWRTETYILKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSAS 450
Cdd:COG2319  18 LALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 451 LDGTVRAWDFKRYKNYKTYTTPTpRQFVSLTADPSGDVVCAGTLDSfEIFVWSKKTGQIKDILSGHEAPVHGLMFSPLTQ 530
Cdd:COG2319  98 ADGTVRLWDLATGLLLRTLTGHT-GAVRSVAFSPDGKTLASGSADG-TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGK 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 531 LLASSSWDYTVRLWDVfASKGTVETFR-HNHDVLTVAFRPDGKQLASSTLDGQINFWDTIEGVLMYTIEGRrdiaGGRVm 609
Cdd:COG2319 176 LLASGSDDGTVRLWDL-ATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH----SGSV- 249

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 15218190 610 tdrrsaansssgkcfTTLCYSADGGYILAAGTSRYICMYDIADQVLLRRFQ 660
Cdd:COG2319 250 ---------------RSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT 285
WD40 COG2319
WD40 repeat [General function prediction only];
32-546 1.24e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.41  E-value: 1.24e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190  32 NRVSVTDLSKNHSVTLPLETSTNICRLASSPDGTFLLAVDEQNRCLFINLPRRVVLHRIT-FKDKVGALKFSPNGKFIAV 110
Cdd:COG2319 100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGKLLAS 179

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 111 G-IGKLVEIWRspgfrraVLPFERVRTFANSDDKVVSLEWSLDSDYLLVGSRDLAARLFCVRKLKGVlnkpFLFLGHRDS 189
Cdd:COG2319 180 GsDDGTVRLWD-------LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL----RTLTGHSGS 248

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 190 VvgcffgvdkmtnkvnraFTIArdgyiFSwgytekdvkmdesedghseppspvtPDradevmvengggvgtelkkrkeyd 269
Cdd:COG2319 249 V-----------------RSVA-----FS-------------------------PD------------------------ 257

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 270 gkglesdeegddddeeymhrGKWVllrkdgcnqASAkvtacdyhqGLDmvvvgfsngvfglyqmpdficihllsisrqkl 349
Cdd:COG2319 258 --------------------GRLL---------ASG---------SAD-------------------------------- 267

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 350 ttavfnergnwltfgcaklGQLLVWDWRTETYILKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTE 429
Cdd:COG2319 268 -------------------GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 430 HTNAVTALHFMADNHSLLSASLDGTVRAWDFkryknyktyttptprqfvsltadpsgdvvcagtldsfeifvwskKTGQI 509
Cdd:COG2319 329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWDL--------------------------------------------ATGEL 364

                       490       500       510
                ....*....|....*....|....*....|....*..
gi 15218190 510 KDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRLWDV 546
Cdd:COG2319 365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 790-895 3.67e-26

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 103.40  E-value: 3.67e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190   790 NEDSLIKKCIFAVAPADIKAVAISVRQKYLERLMEALVDLL-ENCPHLEFILHWCQEICKAHGSSIQRNyRTLLPALRSL 868
Cdd:pfam04003   1 NDEYLLESVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLaERSPHLELLLRWLKFLLRTHGGYLVSN-PDLRPVLRSL 79

                          90       100
                  ....*....|....*....|....*..
gi 15218190   869 QKAITRAHQDLADMCSSNEYTLRYLCS 895
Cdd:pfam04003  80 QKLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 93-459 7.51e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.49  E-value: 7.51e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190  93 KDKVGALKFSPNGKFIAVGIG-KLVEIWRSPGFrravlpfERVRTFANSDDKVVSLEWSLDSDYLLVGSRDLAARLF--- 168
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGdGTIKVWDLETG-------ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWdle 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 169 ---CVRKLKGvlnkpflflgHRDSVVGCFFgvdkmtnkvnraftiARDGYIFSWGYTEKDVKMDESEDGhseppspvtpd 245
Cdd:cd00200  82 tgeCVRTLTG----------HTSYVSSVAF---------------SPDGRILSSSSRDKTIKVWDVETG----------- 125

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 246 radevmvengggvgtelKKRKEYDGkglesdeegddddeeymHRGkWVllrkdgcnqasakvTACDYHQGLDMVVVGFSN 325
Cdd:cd00200 126 -----------------KCLTTLRG-----------------HTD-WV--------------NSVAFSPDGTFVASSSQD 156

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 326 GVFGLYQMPDFICIHLLSISRQKLTTAVFNERGNWLTFGCAKlGQLLVWDWRTETYILKQQGHYFDVNCVTYSPDSQLLA 405
Cdd:cd00200 157 GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 15218190 406 TGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWD 459
Cdd:cd00200 236 SGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
441-660 4.54e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 4.54e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 441 ADNHSLLSASLDGTVRAWDFKRYKNYKTYTTPTPRQFVSLTADPSGDVvcAGTLDSFEIFVWSKKTGQIKDILSGHEAPV 520
Cdd:COG2319   4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARL--AAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 521 HGLMFSPLTQLLASSSWDYTVRLWDVFASKGTVETFRHNHDVLTVAFRPDGKQLASSTLDGQINFWDTIEGVLMYTIEGR 600
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 601 RDIAGGRVMT-DRRSAA-----------NSSSGKCFTTL----------CYSADGGYILAAGTSRYICMYDIADQVLLRR 658
Cdd:COG2319 162 SGAVTSVAFSpDGKLLAsgsddgtvrlwDLATGKLLRTLtghtgavrsvAFSPDGKLLASGSADGTVRLWDLATGKLLRT 241


                ..
gi 15218190 659 FQ 660
Cdd:COG2319 242 LT 243
WD40 COG2319
WD40 repeat [General function prediction only];
31-198 5.91e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 5.91e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190  31 GNRVSVTDLSKNHSVTLPLETSTNICRLASSPDGTFLLAVDEQNRCLFINLPRRVVLHRIT-FKDKVGALKFSPNGKFIA 109
Cdd:COG2319 225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLA 304

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 110 VG-IGKLVEIWRspgfrraVLPFERVRTFANSDDKVVSLEWSLDSDYLLVGSRDLAARLFCVRKLKGVLnkpfLFLGHRD 188
Cdd:COG2319 305 SGsDDGTVRLWD-------LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR----TLTGHTG 373

                       170
                ....*....|
gi 15218190 189 SVVGCFFGVD 198
Cdd:COG2319 374 AVTSVAFSPD 383
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 506-545 5.92e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 5.92e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15218190    506 TGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRLWD 545
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 420-459 3.23e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 3.23e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15218190    420 SGTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWD 459
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 378-417 4.82e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 4.82e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 15218190    378 TETYILKQQGHYFDVNCVTYSPDSQLLATGADDNKVKVWN 417
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
386-417 6.96e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 6.96e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 15218190   386 QGHYFDVNCVTYSPDSQLLATGADDNKVKVWN 417
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
421-459 1.13e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 1.13e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15218190   421 GTCFITFTEHTNAVTALHFMADNHSLLSASLDGTVRAWD 459
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
507-545 1.22e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 1.22e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 15218190   507 GQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYTVRLWD 545
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 558-587 8.42e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 8.42e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 15218190    558 HNHDVLTVAFRPDGKQLASSTLDGQINFWD 587
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 34-200 1.09e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 1.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190  34 VSVTDLSKNHSV-TLPLETStNICRLASSPDGTFLLAVDEQNRCLFINLPRRVVLHRITF-KDKVGALKFSPNGKFIAVG 111
Cdd:cd00200  75 IRLWDLETGECVrTLTGHTS-YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVASS 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 112 IG-KLVEIWRSPGFRRavlpferVRTFANSDDKVVSLEWSLDSDYLLVGSRDLAARLFCVR--KLKGVLNkpflflGHRD 188
Cdd:cd00200 154 SQdGTIKLWDLRTGKC-------VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStgKCLGTLR------GHEN 220

                       170
                ....*....|..
gi 15218190 189 SVVGCFFGVDKM 200
Cdd:cd00200 221 GVNSVAFSPDGY 232
COG5354 COG5354
Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];
501-676 2.21e-04

Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];


Pssm-ID: 227657 [Multi-domain]  Cd Length: 561  Bit Score: 44.87  E-value: 2.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 501 VWSKKTGQIKDILSGHEAPVHGLMFSPLTQLLASSSWDYtVRLWDvFASKGTVETFRHNhDVLTVAFRPDGKQLASstld 580
Cdd:COG5354  16 FWNSQSEVIHTRFESENWPVAYVSESPLGTYLFSEHAAG-VECWG-GPSKAKLVRFRHP-DVKYLDFSPNEKYLVT---- 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190 581 gqinfWDTiEGVLMYTIE----------GRRDIAGGRVMTDRRSAANSSSGKCFttLCYSADGGYIL-AAGTSRYIcmYD 649
Cdd:COG5354  89 -----WSR-EPIIEPEIEispftsknnvFVWDIASGMIVFSFNGISQPYLGWPV--LKFSIDDKYVArVVGSSLYI--HE 158

                       170       180
                ....*....|....*....|....*..
gi 15218190 650 IADQVLLRRFqisHNLSLDGVLDFLHS 676
Cdd:COG5354 159 ITDNIEEHPF---KNLRPVGILDFSIS 182
WD40 pfam00400
WD domain, G-beta repeat;
558-587 4.37e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.37e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 15218190   558 HNHDVLTVAFRPDGKQLASSTLDGQINFWD 587
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 404-559 4.47e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.92  E-value: 4.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190  404 LATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFMADNHSLL-SASLDGTVRAWDFKRYKNYKTYTTPTPRQFVSLTA 482
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15218190  483 DpSGDVVCAGTLDSfEIFVWSKKTGQIK-DILSGHEAPVHGLMFSPlTQLLASSSWDYTVRLWDV-FASKGTVETFRHN 559
Cdd:PLN00181 628 E-SGRSLAFGSADH-KVYYYDLRNPKLPlCTMIGHSKTVSYVRFVD-SSTLVSSSTDNTLKLWDLsMSISGINETPLHS 703
PTZ00421 PTZ00421
coronin; Provisional
 354-462 7.77e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 7.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190  354 FNERGNWLTFGCAKLGQLLVWDWRTE-------TYILKQQGHYFDVNCVTYSPDSQ-LLATGADDNKVKVWNVMSGTCFI 425
Cdd:PTZ00421  83 FNPFDPQKLFTASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVE 162

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 15218190  426 TFTEHTNAVTALHFMADNHSLLSASLDGTVRAWDFKR 462
Cdd:PTZ00421 163 VIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRD 199
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-168 8.76e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 8.76e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190  54 NICRLASSPDGTFLLAVDEQNRCLFINLPRRVVLHRITFKDK-VGALKFSPNGKFIAVG-IGKLVEIWRspgfrraVLPF 131
Cdd:cd00200 179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENgVNSVAFSPDGYLLASGsEDGTIRVWD-------LRTG 251

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 15218190 132 ERVRTFANSDDKVVSLEWSLDSDYLLVGSRDLAARLF 168
Cdd:cd00200 252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
PTZ00420 PTZ00420
coronin; Provisional
 513-587 1.32e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.24  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190  513 LSGHEAPVHGLMFSP-LTQLLASSSWDYTVRLWDVFASKGTVETFR--------HNHDVLTVAFRP-DGKQLASSTLDGQ 582
Cdd:PTZ00420  70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNDESVKEIKdpqcilkgHKKKISIIDWNPmNYYIMCSSGFDSF 149


                 ....*
gi 15218190  583 INFWD 587
Cdd:PTZ00420 150 VNIWD 154
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 532-603 1.41e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.38  E-value: 1.41e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 15218190  532 LASSSWDYTVRLWDVFASKGTVETFRHNHDVLTVAF-RPDGKQLASSTLDGQINFWDTIEGVLMYTIEGRRDI 603
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANI 620
PTZ00421 PTZ00421
coronin; Provisional
 512-606 2.07e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.80  E-value: 2.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218190  512 ILSGHEAPVHGLMFSPL-TQLLASSSWDYTVRLWDVFA-------SKGTVETFRHNHDVLTVAFRPDGKQ-LASSTLDGQ 582
Cdd:PTZ00421  70 ILLGQEGPIIDVAFNPFdPQKLFTASEDGTIMGWGIPEegltqniSDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMV 149

                         90       100
                 ....*....|....*....|....
gi 15218190  583 INFWDTIEGVLMYTIEGRRDIAGG 606
Cdd:PTZ00421 150 VNVWDVERGKAVEVIKCHSDQITS 173
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 392-440 3.21e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.64  E-value: 3.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 15218190   392 VNCVTYSPDSQLLATGADDNKVKVWNVMSGTCFITFTEHTNAVTALHFM 440
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH