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Conserved domains on  [gi|15218276|ref|NP_172448|]
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cell division cycle 5 [Arabidopsis thaliana]

Protein Classification

pre-mRNA-splicing factor CEF1 family protein( domain architecture ID 13419721)

pre-mRNA-splicing factor CEF1 family protein is a SANT/Myb-like DNA-binding domain-containing protein, similar to CEF1 that is involved in pre-mRNA splicing and cell cycle control

CATH:  1.20.58.1880
Gene Ontology:  GO:0003677
PubMed:  8882580
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Myb_Cef pfam11831
pre-mRNA splicing factor component; This family is a region of the Myb-Related Cdc5p/Cef1 ...
 407-656 5.03e-59

pre-mRNA splicing factor component; This family is a region of the Myb-Related Cdc5p/Cef1 proteins, in fungi, and is part of the pre-mRNA splicing factor complex.


:

Pssm-ID: 463366  Cd Length: 227  Bit Score: 200.57  E-value: 5.03e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   407 TPNPMLTPSMTPggaglTPRIGLTPSRDgssFSMTPKGTPFRDELHINED--MDMHESAKLERQRREEARRSLRSGLTGL 484
Cdd:pfam11831   1 TPNPLATPFRTG-----NGGVGATPRRG---FGATPLRTPLRDKLNINPEdgMLVGETPRDEKQRQKEAKEQLRSGLASL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   485 PQPKNEYQIVA--QPPPEESEEPEEKIEEDMSDRIAREKAEEEARQQALLKKRSKVLQRDLPRPPAASLAVIRNSllsad 562
Cdd:pfam11831  73 PKPKNDFEIVLpeEEEEESETEAVEDSEEDAAERDAREQAEREAEEEKELARRSQVVQRGLPRPSEVNLDVLRPA----- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   563 gdkSSVVPPTPIEVADKMVREELLQLLEHDNAKYPLddkaekkkgakNRTNRSASQVLAIDDFDENELQEADKMIKEEGK 642
Cdd:pfam11831 148 ---NDEPPLTDLQPAEELIKKEMATLLHHDALKYPL-----------PGAAQPYLEASPYEDFSDEELAAAKELIAAEMA 213

                         250
                  ....*....|....
gi 15218276   643 FLCVSMGHENKTLD 656
Cdd:pfam11831 214 VVKGGMGHGELSLE 227
REB1 super family cl34920
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 1-231 3.31e-47

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5147:

Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 176.13  E-value: 3.31e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   1 MRIMIKGGVWKNTEDEILKAAVMKYGKNQWARISSLLVRKSAKQCKARWYEWLDPSIKKTEWTREEDEKLLHLAKLLPTQ 80
Cdd:COG5147  14 MQTKRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQ 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276  81 WRTIAPIV-GRTPSQCLERYEKLLdaactkdENYDAADDP---RKLRPGEIDPNPEAKPARPDPVDMDEDEKEMLSEARA 156
Cdd:COG5147  94 WSTIADYKdRRTAQQCVERYVNTL-------EDLSSTHDSklqRRNEFDKIDPFNENSARRPDIYEDELLEREVNREASY 166

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15218276 157 RLANTRGKKAKRKAREKQLEEARRLASLQKRRELKAAGIdGRHRKRKRKGidynaEIPfeKRAPAGFYDTADEDR 231
Cdd:COG5147 167 RLRVPRVSKADVKPREKGEENNPDIEDLQEMKELKSASI-TRHLILPSKS-----EIN--KAFKKGETLALEQEI 233
PTZ00121 super family cl31754
MAEBL; Provisional
 675-834 1.01e-03

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   675 RSAYELSSVAGNADKVAAFQEEMENVRKKMEEDEKKAEHMKAKYKTYTKGHERRAETVWTQIEATLKQAEIGGTEVECFK 754
Cdd:PTZ00121 1470 KKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKAD 1549

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   755 ALKRQEEMAASFRKKNLQEEviKQKETESKLQTRYGNMLAMVEKA--EEIMVGFRAQALKKQEDV--EDSHKLKEAKLAT 830
Cdd:PTZ00121 1550 ELKKAEELKKAEEKKKAEEA--KKAEEDKNMALRKAEEAKKAEEAriEEVMKLYEEEKKMKAEEAkkAEEAKIKAEELKK 1627


                  ....
gi 15218276   831 GEEE 834
Cdd:PTZ00121 1628 AEEE 1631
 
Name Accession Description Interval E-value
Myb_Cef pfam11831
pre-mRNA splicing factor component; This family is a region of the Myb-Related Cdc5p/Cef1 ...
 407-656 5.03e-59

pre-mRNA splicing factor component; This family is a region of the Myb-Related Cdc5p/Cef1 proteins, in fungi, and is part of the pre-mRNA splicing factor complex.


Pssm-ID: 463366  Cd Length: 227  Bit Score: 200.57  E-value: 5.03e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   407 TPNPMLTPSMTPggaglTPRIGLTPSRDgssFSMTPKGTPFRDELHINED--MDMHESAKLERQRREEARRSLRSGLTGL 484
Cdd:pfam11831   1 TPNPLATPFRTG-----NGGVGATPRRG---FGATPLRTPLRDKLNINPEdgMLVGETPRDEKQRQKEAKEQLRSGLASL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   485 PQPKNEYQIVA--QPPPEESEEPEEKIEEDMSDRIAREKAEEEARQQALLKKRSKVLQRDLPRPPAASLAVIRNSllsad 562
Cdd:pfam11831  73 PKPKNDFEIVLpeEEEEESETEAVEDSEEDAAERDAREQAEREAEEEKELARRSQVVQRGLPRPSEVNLDVLRPA----- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   563 gdkSSVVPPTPIEVADKMVREELLQLLEHDNAKYPLddkaekkkgakNRTNRSASQVLAIDDFDENELQEADKMIKEEGK 642
Cdd:pfam11831 148 ---NDEPPLTDLQPAEELIKKEMATLLHHDALKYPL-----------PGAAQPYLEASPYEDFSDEELAAAKELIAAEMA 213

                         250
                  ....*....|....
gi 15218276   643 FLCVSMGHENKTLD 656
Cdd:pfam11831 214 VVKGGMGHGELSLE 227
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 1-231 3.31e-47

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 176.13  E-value: 3.31e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   1 MRIMIKGGVWKNTEDEILKAAVMKYGKNQWARISSLLVRKSAKQCKARWYEWLDPSIKKTEWTREEDEKLLHLAKLLPTQ 80
Cdd:COG5147  14 MQTKRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQ 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276  81 WRTIAPIV-GRTPSQCLERYEKLLdaactkdENYDAADDP---RKLRPGEIDPNPEAKPARPDPVDMDEDEKEMLSEARA 156
Cdd:COG5147  94 WSTIADYKdRRTAQQCVERYVNTL-------EDLSSTHDSklqRRNEFDKIDPFNENSARRPDIYEDELLEREVNREASY 166

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15218276 157 RLANTRGKKAKRKAREKQLEEARRLASLQKRRELKAAGIdGRHRKRKRKGidynaEIPfeKRAPAGFYDTADEDR 231
Cdd:COG5147 167 RLRVPRVSKADVKPREKGEENNPDIEDLQEMKELKSASI-TRHLILPSKS-----EIN--KAFKKGETLALEQEI 233
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 55-106 3.76e-30

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 112.79  E-value: 3.76e-30
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 15218276  55 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIVGRTPSQCLERYEKLLDAA 106
Cdd:cd11659   1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIVGRTAQQCLERYNKLLDEA 52
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 10-70 2.43e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 62.33  E-value: 2.43e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15218276    10 WKNTEDEILKAAVMKYGkNQWARISSLLVRKSAKQCKARWYEWLDPSIKKTEWTREEDEKL 70
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
7-55 1.67e-11

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 59.54  E-value: 1.67e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 15218276      7 GGVWKNTEDEILKAAVMKYGKNQWARISSLLVRKSAKQCKARWYEWLDP 55
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 2-135 8.40e-10

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 60.09  E-value: 8.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276    2 RIMIKGGVWKNTEDEILKAAVMKYGKNQWARI---SSLLvrKSAKQCKARWYEWLDPSIKKTEWTREEDEKLLHLAKLLP 78
Cdd:PLN03212  20 KMGMKRGPWTVEEDEILVSFIKKEGEGRWRSLpkrAGLL--RCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLG 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15218276   79 TQWRTIA-PIVGRTPSQCLERYEKLLDAACTKDenydaADDPRKLRPgeIDPNPEAKP 135
Cdd:PLN03212  98 NRWSLIAgRIPGRTDNEIKNYWNTHLRKKLLRQ-----GIDPQTHKP--LDANNIHKP 148
PTZ00121 PTZ00121
MAEBL; Provisional
 675-834 1.01e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   675 RSAYELSSVAGNADKVAAFQEEMENVRKKMEEDEKKAEHMKAKYKTYTKGHERRAETVWTQIEATLKQAEIGGTEVECFK 754
Cdd:PTZ00121 1470 KKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKAD 1549

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   755 ALKRQEEMAASFRKKNLQEEviKQKETESKLQTRYGNMLAMVEKA--EEIMVGFRAQALKKQEDV--EDSHKLKEAKLAT 830
Cdd:PTZ00121 1550 ELKKAEELKKAEEKKKAEEA--KKAEEDKNMALRKAEEAKKAEEAriEEVMKLYEEEKKMKAEEAkkAEEAKIKAEELKK 1627


                  ....
gi 15218276   831 GEEE 834
Cdd:PTZ00121 1628 AEEE 1631
 
Name Accession Description Interval E-value
Myb_Cef pfam11831
pre-mRNA splicing factor component; This family is a region of the Myb-Related Cdc5p/Cef1 ...
 407-656 5.03e-59

pre-mRNA splicing factor component; This family is a region of the Myb-Related Cdc5p/Cef1 proteins, in fungi, and is part of the pre-mRNA splicing factor complex.


Pssm-ID: 463366  Cd Length: 227  Bit Score: 200.57  E-value: 5.03e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   407 TPNPMLTPSMTPggaglTPRIGLTPSRDgssFSMTPKGTPFRDELHINED--MDMHESAKLERQRREEARRSLRSGLTGL 484
Cdd:pfam11831   1 TPNPLATPFRTG-----NGGVGATPRRG---FGATPLRTPLRDKLNINPEdgMLVGETPRDEKQRQKEAKEQLRSGLASL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   485 PQPKNEYQIVA--QPPPEESEEPEEKIEEDMSDRIAREKAEEEARQQALLKKRSKVLQRDLPRPPAASLAVIRNSllsad 562
Cdd:pfam11831  73 PKPKNDFEIVLpeEEEEESETEAVEDSEEDAAERDAREQAEREAEEEKELARRSQVVQRGLPRPSEVNLDVLRPA----- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   563 gdkSSVVPPTPIEVADKMVREELLQLLEHDNAKYPLddkaekkkgakNRTNRSASQVLAIDDFDENELQEADKMIKEEGK 642
Cdd:pfam11831 148 ---NDEPPLTDLQPAEELIKKEMATLLHHDALKYPL-----------PGAAQPYLEASPYEDFSDEELAAAKELIAAEMA 213

                         250
                  ....*....|....
gi 15218276   643 FLCVSMGHENKTLD 656
Cdd:pfam11831 214 VVKGGMGHGELSLE 227
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 1-231 3.31e-47

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 176.13  E-value: 3.31e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   1 MRIMIKGGVWKNTEDEILKAAVMKYGKNQWARISSLLVRKSAKQCKARWYEWLDPSIKKTEWTREEDEKLLHLAKLLPTQ 80
Cdd:COG5147  14 MQTKRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQ 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276  81 WRTIAPIV-GRTPSQCLERYEKLLdaactkdENYDAADDP---RKLRPGEIDPNPEAKPARPDPVDMDEDEKEMLSEARA 156
Cdd:COG5147  94 WSTIADYKdRRTAQQCVERYVNTL-------EDLSSTHDSklqRRNEFDKIDPFNENSARRPDIYEDELLEREVNREASY 166

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 15218276 157 RLANTRGKKAKRKAREKQLEEARRLASLQKRRELKAAGIdGRHRKRKRKGidynaEIPfeKRAPAGFYDTADEDR 231
Cdd:COG5147 167 RLRVPRVSKADVKPREKGEENNPDIEDLQEMKELKSASI-TRHLILPSKS-----EIN--KAFKKGETLALEQEI 233
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 55-106 3.76e-30

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 112.79  E-value: 3.76e-30
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 15218276  55 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIVGRTPSQCLERYEKLLDAA 106
Cdd:cd11659   1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIVGRTAQQCLERYNKLLDEA 52
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 10-70 2.43e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 62.33  E-value: 2.43e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15218276    10 WKNTEDEILKAAVMKYGkNQWARISSLLVRKSAKQCKARWYEWLDPSIKKTEWTREEDEKL 70
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 10-53 1.37e-11

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 59.90  E-value: 1.37e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 15218276  10 WKNTEDEILKAAVMKYGKNQWARISSLLVRKSAKQCKARWYEWL 53
Cdd:cd00167   2 WTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
7-55 1.67e-11

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 59.54  E-value: 1.67e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 15218276      7 GGVWKNTEDEILKAAVMKYGKNQWARISSLLVRKSAKQCKARWYEWLDP 55
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 8-53 2.24e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 56.36  E-value: 2.24e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15218276     8 GVWKNTEDEILKAAVMKYGkNQWARISSLLVRKSAKQCKARWYEWL 53
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 2-135 8.40e-10

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 60.09  E-value: 8.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276    2 RIMIKGGVWKNTEDEILKAAVMKYGKNQWARI---SSLLvrKSAKQCKARWYEWLDPSIKKTEWTREEDEKLLHLAKLLP 78
Cdd:PLN03212  20 KMGMKRGPWTVEEDEILVSFIKKEGEGRWRSLpkrAGLL--RCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLG 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 15218276   79 TQWRTIA-PIVGRTPSQCLERYEKLLDAACTKDenydaADDPRKLRPgeIDPNPEAKP 135
Cdd:PLN03212  98 NRWSLIAgRIPGRTDNEIKNYWNTHLRKKLLRQ-----GIDPQTHKP--LDANNIHKP 148
PLN03091 PLN03091
hypothetical protein; Provisional
 5-130 4.27e-09

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 59.61  E-value: 4.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276    5 IKGGVWKNTEDEILKAAVMKYGKNQWARISSLL-VRKSAKQCKARWYEWLDPSIKKTEWTREEDEKLLHLAKLLPTQWRT 83
Cdd:PLN03091  12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAgLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWSQ 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 15218276   84 IAP-IVGRTPSQCleryeKLLDAACTKdenydaaddpRKLRPGEIDPN 130
Cdd:PLN03091  92 IAAqLPGRTDNEI-----KNLWNSCLK----------KKLRQRGIDPN 124
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 59-103 1.35e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 51.35  E-value: 1.35e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 15218276    59 KTEWTREEDEKLLHLAKLLPTQWRTIAPIV-GRTPSQCLERYEKLL 103
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLpGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
59-103 2.00e-07

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 47.99  E-value: 2.00e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 15218276     59 KTEWTREEDEKLLHLAKLLPT-QWRTIAPIVG-RTPSQCLERYEKLL 103
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKnNWEKIAKELPgRTAEQCRERWRNLL 47
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 61-103 3.62e-07

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 47.18  E-value: 3.62e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 15218276  61 EWTREEDEKLLHLAKLLPT-QWRTIAPIVG-RTPSQCLERYEKLL 103
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKnNWEKIAKELPgRTPKQCRERWRNLL 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 62-117 3.79e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 44.99  E-value: 3.79e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 15218276    62 WTREEDEKLLHLAKLLPTQWRTIAPIVG-RTPSQCLERYEKLLDAACTKDENYDAAD 117
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRWRRKLNPKISRGPWSKEED 57
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 10-49 2.90e-04

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 39.09  E-value: 2.90e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 15218276  10 WKNTEDEILKAAVMKYGKNQWARI---SSLLVRKSAKQCKARW 49
Cdd:cd11660   3 WTDEEDEALVEGVEKYGVGNWAKIlkdYFFVNNRTSVDLKDKW 45
PTZ00121 PTZ00121
MAEBL; Provisional
 675-834 1.01e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   675 RSAYELSSVAGNADKVAAFQEEMENVRKKMEEDEKKAEHMKAKYKTYTKGHERRAETVWTQIEATLKQAEIGGTEVECFK 754
Cdd:PTZ00121 1470 KKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKAD 1549

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   755 ALKRQEEMAASFRKKNLQEEviKQKETESKLQTRYGNMLAMVEKA--EEIMVGFRAQALKKQEDV--EDSHKLKEAKLAT 830
Cdd:PTZ00121 1550 ELKKAEELKKAEEKKKAEEA--KKAEEDKNMALRKAEEAKKAEEAriEEVMKLYEEEKKMKAEEAkkAEEAKIKAEELKK 1627


                  ....
gi 15218276   831 GEEE 834
Cdd:PTZ00121 1628 AEEE 1631
PTZ00121 PTZ00121
MAEBL; Provisional
 592-840 2.19e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   592 DNAKYPLDDKAEKKKGAKNRTNRSASQVLAiddfdENELQEADKMIKEEGKFLCVSMGHENKTLDDFVEAHNTCVNDlmy 671
Cdd:PTZ00121 1332 DAAKKKAEEAKKAAEAAKAEAEAAADEAEA-----AEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEED--- 1403

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   672 fpTRSAYELSSVAGNADKVAAFQEEMENVRKKmEEDEKKAEHMKAKYKTYTKGHE-RRAETVWTQIEATLKQAEIGGTEV 750
Cdd:PTZ00121 1404 --KKKADELKKAAAAKKKADEAKKKAEEKKKA-DEAKKKAEEAKKADEAKKKAEEaKKAEEAKKKAEEAKKADEAKKKAE 1480

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   751 ECFKA----------LKRQEEMAASFRKKNLQEEVIKQKETESKLQTRYGNMLAMVEKAEEIMVGFRAQALKKQEDVEDS 820
Cdd:PTZ00121 1481 EAKKAdeakkkaeeaKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKA 1560

                         250       260
                  ....*....|....*....|
gi 15218276   821 HKLKEAKLATGEEEDIAIAM 840
Cdd:PTZ00121 1561 EEKKKAEEAKKAEEDKNMAL 1580
PTZ00121 PTZ00121
MAEBL; Provisional
 601-837 5.70e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 5.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   601 KAEKKKGAKNRtnRSASQVLAIDDFDE-NELQEADKMIK-------EEGKFLCVSMGHENKTLDdfvEAHNTCVNDLMYF 672
Cdd:PTZ00121 1529 KAEEAKKADEA--KKAEEKKKADELKKaEELKKAEEKKKaeeakkaEEDKNMALRKAEEAKKAE---EARIEEVMKLYEE 1603

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   673 PTRSAYELSSVAGNADKVAAFQEEMENVRKKMEEDEKKAEHMKAKYKTYTKGHER---RAETVWTQIEATLKQAEIGGTE 749
Cdd:PTZ00121 1604 EKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEEnkiKAAEEAKKAEEDKKKAEEAKKA 1683

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218276   750 VECFKalKRQEEMAASFRKKNLQEEVIKQKETESKLQTRygnmlamVEKAEEIMvGFRAQALKKQEDvEDSHKLKEAKLA 829
Cdd:PTZ00121 1684 EEDEK--KAAEALKKEAEEAKKAEELKKKEAEEKKKAEE-------LKKAEEEN-KIKAEEAKKEAE-EDKKKAEEAKKD 1752


                  ....*...
gi 15218276   830 TGEEEDIA 837
Cdd:PTZ00121 1753 EEEKKKIA 1760
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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