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Conserved domains on  [gi|42561854|ref|NP_172400|]
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uncharacterized protein AT1G09290 [Arabidopsis thaliana]

Protein Classification

THUMP domain-containing protein( domain architecture ID 37795)

THUMP domain-containing protein similar to human THUMP domain-containing protein 1 (THUMPD1) that functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation

CATH:  3.30.2300.10
Gene Ontology:  GO:0006400|GO:0003723
PubMed:  11295541
SCOP:  4002010

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THUMP super family cl12076
THUMP domain, predicted to bind RNA; The THUMP domain is named after THioUridine synthases, ...
 141-322 6.01e-10

THUMP domain, predicted to bind RNA; The THUMP domain is named after THioUridine synthases, RNA Methyltransferases and Pseudo-uridine synthases. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


The actual alignment was detected with superfamily member cd11717:

Pssm-ID: 472271  Cd Length: 158  Bit Score: 57.21  E-value: 6.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42561854 141 KLANEEHNSLMSLVKLTKSGLLLFTFPVENSPntTNIVSRVFQSMESGALKAPIWCHRIFPVQATCGLTEKELRETVSKL 220
Cdd:cd11717  12 RKAIRELYNLLQSVETGVKNVVFIKTRPPVDP--VELVEKIFEDAASTKKKRTRFIQRLIPIDVTCKASLEEIEKLAKEL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42561854 221 VQRFVndkdNTLSKPVKFAAGYQRRGAEEtkgkirkdasdvlvqcplLDRIKCFETVAAGVKDIVPdsvVDLKSPELCVL 300
Cdd:cd11717  90 LKKHF----PTAEPPKTFAVECKSRNNNK------------------LSRDEVIKAVAELVPEIHK---VDLKNPDKVIL 144

                       170       180
                ....*....|....*....|..
gi 42561854 301 VELLPLsrissgsfVAAVSVLP 322
Cdd:cd11717 145 VEVIKN--------VCGISVVK 158
 
Name Accession Description Interval E-value
THUMP_THUMPD1_like cd11717
THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins ...
 141-322 6.01e-10

THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins including THUMP domain-containing protein 1 and Saccharomyces cerevisiae Tan1. Tan1 is non essential and has been shown to be required for the formation of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA. To date, there is no functional information available about THUMPD1. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212586  Cd Length: 158  Bit Score: 57.21  E-value: 6.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42561854 141 KLANEEHNSLMSLVKLTKSGLLLFTFPVENSPntTNIVSRVFQSMESGALKAPIWCHRIFPVQATCGLTEKELRETVSKL 220
Cdd:cd11717  12 RKAIRELYNLLQSVETGVKNVVFIKTRPPVDP--VELVEKIFEDAASTKKKRTRFIQRLIPIDVTCKASLEEIEKLAKEL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42561854 221 VQRFVndkdNTLSKPVKFAAGYQRRGAEEtkgkirkdasdvlvqcplLDRIKCFETVAAGVKDIVPdsvVDLKSPELCVL 300
Cdd:cd11717  90 LKKHF----PTAEPPKTFAVECKSRNNNK------------------LSRDEVIKAVAELVPEIHK---VDLKNPDKVIL 144

                       170       180
                ....*....|....*....|..
gi 42561854 301 VELLPLsrissgsfVAAVSVLP 322
Cdd:cd11717 145 VEVIKN--------VCGISVVK 158
 
Name Accession Description Interval E-value
THUMP_THUMPD1_like cd11717
THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins ...
 141-322 6.01e-10

THUMP domain-containing protein 1-like; This family contains THUMP domain-only proteins including THUMP domain-containing protein 1 and Saccharomyces cerevisiae Tan1. Tan1 is non essential and has been shown to be required for the formation of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA. To date, there is no functional information available about THUMPD1. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212586  Cd Length: 158  Bit Score: 57.21  E-value: 6.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42561854 141 KLANEEHNSLMSLVKLTKSGLLLFTFPVENSPntTNIVSRVFQSMESGALKAPIWCHRIFPVQATCGLTEKELRETVSKL 220
Cdd:cd11717  12 RKAIRELYNLLQSVETGVKNVVFIKTRPPVDP--VELVEKIFEDAASTKKKRTRFIQRLIPIDVTCKASLEEIEKLAKEL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42561854 221 VQRFVndkdNTLSKPVKFAAGYQRRGAEEtkgkirkdasdvlvqcplLDRIKCFETVAAGVKDIVPdsvVDLKSPELCVL 300
Cdd:cd11717  90 LKKHF----PTAEPPKTFAVECKSRNNNK------------------LSRDEVIKAVAELVPEIHK---VDLKNPDKVIL 144

                       170       180
                ....*....|....*....|..
gi 42561854 301 VELLPLsrissgsfVAAVSVLP 322
Cdd:cd11717 145 VEVIKN--------VCGISVVK 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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