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Conserved domains on  [gi|15218674|ref|NP_171800|]
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Phototropic-responsive NPH3 family protein [Arabidopsis thaliana]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 13605777)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) and NPH3 domain-containing protein may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 205-479 8.48e-101

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


:

Pssm-ID: 460777  Cd Length: 218  Bit Score: 305.95  E-value: 8.48e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218674   205 DWWGKSLAVLNLDFFQRVISAVKSKGLIQDVISKILISYTNKSLQGLIvRDPKLEKERVLDSegKKKQRLIVETIVRLLP 284
Cdd:pfam03000   1 DWWFEDLSELSIDLFKRVISAMKSKGMKPEVIGEALMHYAKKWLPGLS-RSSSSSASRSEDD--NSKQRELLETIVSLLP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218674   285 TQgrRSSVPMAFLSSLLKMVIatsSSASTGSCRSDLERRIGLQLDQAILEDVLIPINLNGTnnTMYDIDsilrifsifln 364
Cdd:pfam03000  78 SE--KGSVSCSFLLGLLRTAI---ILGASEACREELERRIGLQLEQATLDDLLIPSYSGEE--TLYDVD----------- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218674   365 ldeddeeeehhhlqfrdetemiydfdspgspkqssiLKVSKLMDNYLAEIAMDPNLTTSKFIALAELLPDHARIISDGLY 444
Cdd:pfam03000 140 ------------------------------------LKVAKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLY 183

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 15218674   445 RAVDIYLKVHPNIKDSERYRLCKTIDSQKLSQEAC 479
Cdd:pfam03000 184 RAIDIYLKAHPGLSESERKRLCRLMDCQKLSLEAC 218
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 33-130 5.85e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18312:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 105  Bit Score: 116.66  E-value: 5.85e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218674  33 ISDVSSDLTVQVGSSSFCLHKFPLVSRSGKIRKL---LADPKISNVCLSNAPGGSEAFELAAKFCYGINIEINLLNIAKL 109
Cdd:cd18312   5 DTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLassSSESDPSEIELNDFPGGAEAFELVAKFCYGMPINLTATNVVGL 84

                        90       100
                ....*....|....*....|.
gi 15218674 110 RCASHYLEMTEDFSEENLASK 130
Cdd:cd18312  85 RCAAEYLEMTESGNLGNLIDK 105
 
Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 205-479 8.48e-101

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


Pssm-ID: 460777  Cd Length: 218  Bit Score: 305.95  E-value: 8.48e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218674   205 DWWGKSLAVLNLDFFQRVISAVKSKGLIQDVISKILISYTNKSLQGLIvRDPKLEKERVLDSegKKKQRLIVETIVRLLP 284
Cdd:pfam03000   1 DWWFEDLSELSIDLFKRVISAMKSKGMKPEVIGEALMHYAKKWLPGLS-RSSSSSASRSEDD--NSKQRELLETIVSLLP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218674   285 TQgrRSSVPMAFLSSLLKMVIatsSSASTGSCRSDLERRIGLQLDQAILEDVLIPINLNGTnnTMYDIDsilrifsifln 364
Cdd:pfam03000  78 SE--KGSVSCSFLLGLLRTAI---ILGASEACREELERRIGLQLEQATLDDLLIPSYSGEE--TLYDVD----------- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218674   365 ldeddeeeehhhlqfrdetemiydfdspgspkqssiLKVSKLMDNYLAEIAMDPNLTTSKFIALAELLPDHARIISDGLY 444
Cdd:pfam03000 140 ------------------------------------LKVAKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLY 183

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 15218674   445 RAVDIYLKVHPNIKDSERYRLCKTIDSQKLSQEAC 479
Cdd:pfam03000 184 RAIDIYLKAHPGLSESERKRLCRLMDCQKLSLEAC 218
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 33-130 5.85e-31

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 116.66  E-value: 5.85e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218674  33 ISDVSSDLTVQVGSSSFCLHKFPLVSRSGKIRKL---LADPKISNVCLSNAPGGSEAFELAAKFCYGINIEINLLNIAKL 109
Cdd:cd18312   5 DTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLassSSESDPSEIELNDFPGGAEAFELVAKFCYGMPINLTATNVVGL 84

                        90       100
                ....*....|....*....|.
gi 15218674 110 RCASHYLEMTEDFSEENLASK 130
Cdd:cd18312  85 RCAAEYLEMTESGNLGNLIDK 105
 
Name Accession Description Interval E-value
NPH3 pfam03000
NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source ...
 205-479 8.48e-101

NPH3 family; Phototropism of Arabidopsis thaliana seedlings in response to a blue light source is initiated by nonphototropic hypocotyl 1 (NPH1), a light-activated serine-threonine protein kinase. Mutations in NPH3 disrupt early signaling occurring downstream of the NPH1 photoreceptor. The NPH3 gene encodes a NPH1-interacting protein. NPH3 is a member of a large protein family, apparently specific to higher plants, and may function as an adapter or scaffold protein to bring together the enzymatic components of a NPH1-activated phosphorelay.


Pssm-ID: 460777  Cd Length: 218  Bit Score: 305.95  E-value: 8.48e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218674   205 DWWGKSLAVLNLDFFQRVISAVKSKGLIQDVISKILISYTNKSLQGLIvRDPKLEKERVLDSegKKKQRLIVETIVRLLP 284
Cdd:pfam03000   1 DWWFEDLSELSIDLFKRVISAMKSKGMKPEVIGEALMHYAKKWLPGLS-RSSSSSASRSEDD--NSKQRELLETIVSLLP 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218674   285 TQgrRSSVPMAFLSSLLKMVIatsSSASTGSCRSDLERRIGLQLDQAILEDVLIPINLNGTnnTMYDIDsilrifsifln 364
Cdd:pfam03000  78 SE--KGSVSCSFLLGLLRTAI---ILGASEACREELERRIGLQLEQATLDDLLIPSYSGEE--TLYDVD----------- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218674   365 ldeddeeeehhhlqfrdetemiydfdspgspkqssiLKVSKLMDNYLAEIAMDPNLTTSKFIALAELLPDHARIISDGLY 444
Cdd:pfam03000 140 ------------------------------------LKVAKLVDGYLAEIASDPNLKLSKFIALAEALPDSARPTHDGLY 183

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 15218674   445 RAVDIYLKVHPNIKDSERYRLCKTIDSQKLSQEAC 479
Cdd:pfam03000 184 RAIDIYLKAHPGLSESERKRLCRLMDCQKLSLEAC 218
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 33-130 5.85e-31

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 116.66  E-value: 5.85e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218674  33 ISDVSSDLTVQVGSSSFCLHKFPLVSRSGKIRKL---LADPKISNVCLSNAPGGSEAFELAAKFCYGINIEINLLNIAKL 109
Cdd:cd18312   5 DTGEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLassSSESDPSEIELNDFPGGAEAFELVAKFCYGMPINLTATNVVGL 84

                        90       100
                ....*....|....*....|.
gi 15218674 110 RCASHYLEMTEDFSEENLASK 130
Cdd:cd18312  85 RCAAEYLEMTESGNLGNLIDK 105
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-116 2.42e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 45.62  E-value: 2.42e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218674  38 SDLTVQVGSSSFCLHKFPLVSRSGKIRKLL----ADPKISNVCLSNAPggSEAFELAAKFCYGINIEINLLNIAKLRCAS 113
Cdd:cd18186   2 CDVTLVVGGREFPAHRAVLAARSPYFRAMFssgmKESSSSEIELDDVS--PEAFEALLDYIYTGELELSEENVEELLAAA 79


                ...
gi 15218674 114 HYL 116
Cdd:cd18186  80 DKL 82
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-120 3.11e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 37.81  E-value: 3.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15218674  39 DLTVQVGSSSFCLHKFPLVSRSGKIRKLLADPKISNVCLSNAPGGSEAFELAAKFCYGINIEINLLNIAKLRCASHYLEM 118
Cdd:cd18217  20 DCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLDQSQVSADGFQKLLEFIYTGNLNLDSWNVAEIHQAASYLGM 99


                ..
gi 15218674 119 TE 120
Cdd:cd18217 100 EE 101
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 33-95 9.24e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 36.11  E-value: 9.24e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15218674  33 ISDVSSDLTVQVGSSSFCLHKFPLVSRSGKIRKLLADPKISN--------VCLSNAPGgsEAFELAAKFCY 95
Cdd:cd18301  14 EGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSedavgcdvVHIEKVPP--EIFEQLLQFIY 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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