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Conserved domains on  [gi|13878227|ref|NP_113569|]
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tRNA (34-2'-O)-methyltransferase regulator WDR6 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234975)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 110-325 4.55e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 80.07  E-value: 4.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  110 SGLWNMSDWIWDVRwIEGNVAVALGHNsvvlyDPVIGCmlqDVPCTDRctlssaclvgdtwkelTIVAGAVSNELLIWyp 189
Cdd:cd00200  110 SSSRDKTIKVWDVE-TGKCLTTLRGHT-----DWVNSV---AFSPDGT----------------FVASSSQDGTIKLW-- 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  190 atALTDNKPVapdRRVSGHVGVIFSMSYLESKGLLATASEDRSVRLWkvgDLRVPggrvQNIGHCFGHSARVWQVKLLEN 269
Cdd:cd00200  163 --DLRTGKCV---ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW---DLSTG----KCLGTLRGHENGVNSVAFSPD 230

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 13878227  270 --YLISAGEDCVCLVWSHE-GEILQAFRGHRGRgIRAIATHERQAWVVTGGDDSGIRLW 325
Cdd:cd00200  231 gyLLASGSEDGTIRVWDLRtGECVQTLSGHTNS-VTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
174-521 1.01e-14

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 1.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  174 TIVAGAVSNELLIWYPATALtdnkpvaPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRLWKVGDlrvpGGRVQNIGh 253
Cdd:COG2319   92 LLASASADGTVRLWDLATGL-------LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT----GKLLRTLT- 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  254 cfGHSARVWQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHRGRgIRAIATHERQAWVVTGGDDSGIRLWHLAGR 330
Cdd:COG2319  160 --GHSGAVTSVAFSPDgkLLASGSDDGTVRLWDlATGKLLRTLTGHTGA-VRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  331 ------GYPGLGVSSLSFkSPSrpgalkavtlaGSWrVLAVTDVGSLYLYDLEVKSWEQLLEDNRFRSYCLleaAPGPEG 404
Cdd:COG2319  237 kllrtlTGHSGSVRSVAF-SPD-----------GRL-LASGSADGTVRLWDLATGELLRTLTGHSGGVNSV---AFSPDG 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  405 fGLCALANGEGLVKVVPINTPTAAVEQKLFQGKVHSLSWALRGyeELLLLASGPGGViaclEISAAPTGKAIFVKErcry 484
Cdd:COG2319  301 -KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTV----RLWDLATGELLRTLT---- 369

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 13878227  485 llppSKQRWHTCSAFLPPGDFLVCGDRRGSVMLFPVR 521
Cdd:COG2319  370 ----GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 741-1014 1.64e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 1.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  741 DIVITGSEDTTVCVLALPTTTgsahALTSVCNHISSVRALAVWAVGTpggpqdtrpgltaQVVSAGGRAEIHCFSVMVTP 820
Cdd:cd00200   22 KLLATGSGDGTIKVWDLETGE----LLRTLKGHTGPVRDVAASADGT-------------YLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  821 DASTpsrLACH---VMHLSSHRLDEY------------WDRQRNKHKMIKVDPETRYMSLAIceldndrpgLGPGPLVAA 885
Cdd:cd00200   85 CVRT---LTGHtsyVSSVAFSPDGRIlssssrdktikvWDVETGKCLTTLRGHTDWVNSVAF---------SPDGTFVAS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  886 ACSDGAVRLFLLqDSGRILHLLAesfHHKRCVLKVhSFTheaPNQRRrliLCSAATDGSLAFWDLTTamdkgsttlelpa 965
Cdd:cd00200  153 SSQDGTIKLWDL-RTGKCVATLT---GHTGEVNSV-AFS---PDGEK---LLSSSSDGTIKLWDLST------------- 208

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 13878227  966 hpglpyqmGTPSMTVQAHSCGVNSLHTLPTpegHHLVASGSEDGSLHVF 1014
Cdd:cd00200  209 --------GKCLGTLRGHENGVNSVAFSPD---GYLLASGSEDGTIRVW 246
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 110-325 4.55e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.07  E-value: 4.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  110 SGLWNMSDWIWDVRwIEGNVAVALGHNsvvlyDPVIGCmlqDVPCTDRctlssaclvgdtwkelTIVAGAVSNELLIWyp 189
Cdd:cd00200  110 SSSRDKTIKVWDVE-TGKCLTTLRGHT-----DWVNSV---AFSPDGT----------------FVASSSQDGTIKLW-- 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  190 atALTDNKPVapdRRVSGHVGVIFSMSYLESKGLLATASEDRSVRLWkvgDLRVPggrvQNIGHCFGHSARVWQVKLLEN 269
Cdd:cd00200  163 --DLRTGKCV---ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW---DLSTG----KCLGTLRGHENGVNSVAFSPD 230

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 13878227  270 --YLISAGEDCVCLVWSHE-GEILQAFRGHRGRgIRAIATHERQAWVVTGGDDSGIRLW 325
Cdd:cd00200  231 gyLLASGSEDGTIRVWDLRtGECVQTLSGHTNS-VTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
174-521 1.01e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 1.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  174 TIVAGAVSNELLIWYPATALtdnkpvaPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRLWKVGDlrvpGGRVQNIGh 253
Cdd:COG2319   92 LLASASADGTVRLWDLATGL-------LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT----GKLLRTLT- 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  254 cfGHSARVWQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHRGRgIRAIATHERQAWVVTGGDDSGIRLWHLAGR 330
Cdd:COG2319  160 --GHSGAVTSVAFSPDgkLLASGSDDGTVRLWDlATGKLLRTLTGHTGA-VRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  331 ------GYPGLGVSSLSFkSPSrpgalkavtlaGSWrVLAVTDVGSLYLYDLEVKSWEQLLEDNRFRSYCLleaAPGPEG 404
Cdd:COG2319  237 kllrtlTGHSGSVRSVAF-SPD-----------GRL-LASGSADGTVRLWDLATGELLRTLTGHSGGVNSV---AFSPDG 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  405 fGLCALANGEGLVKVVPINTPTAAVEQKLFQGKVHSLSWALRGyeELLLLASGPGGViaclEISAAPTGKAIFVKErcry 484
Cdd:COG2319  301 -KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTV----RLWDLATGELLRTLT---- 369

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 13878227  485 llppSKQRWHTCSAFLPPGDFLVCGDRRGSVMLFPVR 521
Cdd:COG2319  370 ----GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
174-329 2.27e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.49  E-value: 2.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  174 TIVAGAVSNELLIWYPATAltdnkpvAPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRLWKVGDLRVPGGRVqnigh 253
Cdd:COG2319  260 LLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT----- 327

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13878227  254 cfGHSARVWQVKL--LENYLISAGEDCVCLVWS-HEGEILQAFRGHRGRgIRAIATHERQAWVVTGGDDSGIRLWHLAG 329
Cdd:COG2319  328 --GHTGAVRSVAFspDGKTLASGSDDGTVRLWDlATGELLRTLTGHTGA-VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 741-1014 1.64e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 1.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  741 DIVITGSEDTTVCVLALPTTTgsahALTSVCNHISSVRALAVWAVGTpggpqdtrpgltaQVVSAGGRAEIHCFSVMVTP 820
Cdd:cd00200   22 KLLATGSGDGTIKVWDLETGE----LLRTLKGHTGPVRDVAASADGT-------------YLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  821 DASTpsrLACH---VMHLSSHRLDEY------------WDRQRNKHKMIKVDPETRYMSLAIceldndrpgLGPGPLVAA 885
Cdd:cd00200   85 CVRT---LTGHtsyVSSVAFSPDGRIlssssrdktikvWDVETGKCLTTLRGHTDWVNSVAF---------SPDGTFVAS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  886 ACSDGAVRLFLLqDSGRILHLLAesfHHKRCVLKVhSFTheaPNQRRrliLCSAATDGSLAFWDLTTamdkgsttlelpa 965
Cdd:cd00200  153 SSQDGTIKLWDL-RTGKCVATLT---GHTGEVNSV-AFS---PDGEK---LLSSSSDGTIKLWDLST------------- 208

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 13878227  966 hpglpyqmGTPSMTVQAHSCGVNSLHTLPTpegHHLVASGSEDGSLHVF 1014
Cdd:cd00200  209 --------GKCLGTLRGHENGVNSVAFSPD---GYLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
880-1083 3.20e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 3.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  880 GPLVAAACSDGAVRLFLLqDSGRILHLLAesfHHKRCVLKVhSFTheaPNQRRrliLCSAATDGSLAFWDLTTamdkgst 959
Cdd:COG2319  216 GKLLASGSADGTVRLWDL-ATGKLLRTLT---GHSGSVRSV-AFS---PDGRL---LASGSADGTVRLWDLAT------- 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  960 tlelpahpglpyqmGTPSMTVQAHSCGVNSLHTlpTPEGHHLvASGSEDGSLHVFTLAvkmpepeeaDGEaelvpQLCVL 1039
Cdd:COG2319  278 --------------GELLRTLTGHSGGVNSVAF--SPDGKLL-ASGSDDGTVRLWDLA---------TGK-----LLRTL 326

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 13878227 1040 EeysvpcAHAAHVTGVKIlSP--KLMVSASIDQRLTFWRLGQGEPT 1083
Cdd:COG2319  327 T------GHTGAVRSVAF-SPdgKTLASGSDDGTVRLWDLATGELL 365
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 201-237 2.16e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.16e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 13878227     201 PDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRLWK 237
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
287-325 3.34e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 3.34e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 13878227    287 GEILQAFRGHRGrGIRAIATHERQAWVVTGGDDSGIRLW 325
Cdd:pfam00400    1 GKLLKTLEGHTG-SVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 110-325 4.55e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.07  E-value: 4.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  110 SGLWNMSDWIWDVRwIEGNVAVALGHNsvvlyDPVIGCmlqDVPCTDRctlssaclvgdtwkelTIVAGAVSNELLIWyp 189
Cdd:cd00200  110 SSSRDKTIKVWDVE-TGKCLTTLRGHT-----DWVNSV---AFSPDGT----------------FVASSSQDGTIKLW-- 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  190 atALTDNKPVapdRRVSGHVGVIFSMSYLESKGLLATASEDRSVRLWkvgDLRVPggrvQNIGHCFGHSARVWQVKLLEN 269
Cdd:cd00200  163 --DLRTGKCV---ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW---DLSTG----KCLGTLRGHENGVNSVAFSPD 230

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 13878227  270 --YLISAGEDCVCLVWSHE-GEILQAFRGHRGRgIRAIATHERQAWVVTGGDDSGIRLW 325
Cdd:cd00200  231 gyLLASGSEDGTIRVWDLRtGECVQTLSGHTNS-VTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
174-521 1.01e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 1.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  174 TIVAGAVSNELLIWYPATALtdnkpvaPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRLWKVGDlrvpGGRVQNIGh 253
Cdd:COG2319   92 LLASASADGTVRLWDLATGL-------LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT----GKLLRTLT- 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  254 cfGHSARVWQVKLLEN--YLISAGEDCVCLVWS-HEGEILQAFRGHRGRgIRAIATHERQAWVVTGGDDSGIRLWHLAGR 330
Cdd:COG2319  160 --GHSGAVTSVAFSPDgkLLASGSDDGTVRLWDlATGKLLRTLTGHTGA-VRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  331 ------GYPGLGVSSLSFkSPSrpgalkavtlaGSWrVLAVTDVGSLYLYDLEVKSWEQLLEDNRFRSYCLleaAPGPEG 404
Cdd:COG2319  237 kllrtlTGHSGSVRSVAF-SPD-----------GRL-LASGSADGTVRLWDLATGELLRTLTGHSGGVNSV---AFSPDG 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  405 fGLCALANGEGLVKVVPINTPTAAVEQKLFQGKVHSLSWALRGyeELLLLASGPGGViaclEISAAPTGKAIFVKErcry 484
Cdd:COG2319  301 -KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTV----RLWDLATGELLRTLT---- 369

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 13878227  485 llppSKQRWHTCSAFLPPGDFLVCGDRRGSVMLFPVR 521
Cdd:COG2319  370 ----GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
174-329 2.27e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.49  E-value: 2.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  174 TIVAGAVSNELLIWYPATAltdnkpvAPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRLWKVGDLRVPGGRVqnigh 253
Cdd:COG2319  260 LLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT----- 327

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 13878227  254 cfGHSARVWQVKL--LENYLISAGEDCVCLVWS-HEGEILQAFRGHRGRgIRAIATHERQAWVVTGGDDSGIRLWHLAG 329
Cdd:COG2319  328 --GHTGAVRSVAFspDGKTLASGSDDGTVRLWDlATGELLRTLTGHTGA-VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 203-462 8.32e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.44  E-value: 8.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  203 RRVSGHVGVIFSMSYLESKGLLATASEDRSVRLWKVGDLRVPGGRVqnighcfGHSARVWQVKLL--ENYLISAGEDCVC 280
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-------GHTGPVRDVAASadGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  281 LVWS-HEGEILQAFRGHRGrGIRAIATHERQAWVVTGGDDSGIRLWHLAG-------RGYPGlGVSSLSFKSPSRpgalk 352
Cdd:cd00200   76 RLWDlETGECVRTLTGHTS-YVSSVAFSPDGRILSSSSRDKTIKVWDVETgkclttlRGHTD-WVNSVAFSPDGT----- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  353 avTLAGSWRvlavtDvGSLYLYDLEVKSWEQLLEDNRFRSYCLleaAPGPEGFGLCAlANGEGLVKVVPINTPTAAVEQK 432
Cdd:cd00200  149 --FVASSSQ-----D-GTIKLWDLRTGKCVATLTGHTGEVNSV---AFSPDGEKLLS-SSSDGTIKLWDLSTGKCLGTLR 216

                        250       260       270
                 ....*....|....*....|....*....|
gi 13878227  433 LFQGKVHSLSWALRGYeelLLLASGPGGVI 462
Cdd:cd00200  217 GHENGVNSVAFSPDGY---LLASGSEDGTI 243
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-327 4.26e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 4.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  175 IVAGAVSNELLIWypataltDNKPVAPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRLWkvgDLRvPGGRVQNIghc 254
Cdd:cd00200  108 LSSSSRDKTIKVW-------DVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW---DLR-TGKCVATL--- 173

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 13878227  255 FGHSARVWQVKLLENY--LISAGEDCVCLVWSH-EGEILQAFRGHRGrGIRAIATHERQAWVVTGGDDSGIRLWHL 327
Cdd:cd00200  174 TGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLsTGKCLGTLRGHEN-GVNSVAFSPDGYLLASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
190-518 8.27e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 8.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  190 ATALTDNKPVAPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRLWKVGDLRVPGGRVqnighcfGHSARVWQVKLLEN 269
Cdd:COG2319   17 ALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL-------GHTAAVLSVAFSPD 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  270 --YLISAGEDCVCLVWSHE-GEILQAFRGHRGRgIRAIATHERQAWVVTGGDDSGIRLWHLAG-------RGYPGlGVSS 339
Cdd:COG2319   90 grLLASASADGTVRLWDLAtGLLLRTLTGHTGA-VRSVAFSPDGKTLASGSADGTVRLWDLATgkllrtlTGHSG-AVTS 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  340 LSFkSPSrpgalkavtlaGSWRVLAVTDvGSLYLYDLEVKSWEQLLEDNRFRSYCLleaAPGPEGFGLcALANGEGLVKV 419
Cdd:COG2319  168 VAF-SPD-----------GKLLASGSDD-GTVRLWDLATGKLLRTLTGHTGAVRSV---AFSPDGKLL-ASGSADGTVRL 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  420 VPINTPTAAVEQKLFQGKVHSLSWALRGyeELLLLASGPGGViaclEISAAPTGKAIFvkercrylLPPSKQRWHTCSAF 499
Cdd:COG2319  231 WDLATGKLLRTLTGHSGSVRSVAFSPDG--RLLASGSADGTV----RLWDLATGELLR--------TLTGHSGGVNSVAF 296

                        330
                 ....*....|....*....
gi 13878227  500 LPPGDFLVCGDRRGSVMLF 518
Cdd:COG2319  297 SPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
190-663 1.09e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  190 ATALTDNKPVAPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRLWkvgdlRVPGGRVQNIGHcfGHSARVWQVKLLEN 269
Cdd:COG2319   59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW-----DLATGLLLRTLT--GHTGAVRSVAFSPD 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  270 --YLISAGEDCVCLVWS-HEGEILQAFRGHRGRgIRAIATHERQAWVVTGGDDSGIRLWHLAG-------RGYPGlGVSS 339
Cdd:COG2319  132 gkTLASGSADGTVRLWDlATGKLLRTLTGHSGA-VTSVAFSPDGKLLASGSDDGTVRLWDLATgkllrtlTGHTG-AVRS 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  340 LSFkSPSRpgalkavtlagswRVLAVTDV-GSLYLYDLEVKSWEQLLEDNRFRSYCLleaAPGPEGfGLCALANGEGLVK 418
Cdd:COG2319  210 VAF-SPDG-------------KLLASGSAdGTVRLWDLATGKLLRTLTGHSGSVRSV---AFSPDG-RLLASGSADGTVR 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  419 VvpintptaaveqklfqgkvhslsWALRGYEELLLLASGPGGVIACleisaaptgkaifvkercryllppskqrwhtcsA 498
Cdd:COG2319  272 L-----------------------WDLATGELLRTLTGHSGGVNSV---------------------------------A 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  499 FLPPGDFLVCGDRRGSVMLFPVrpclfkkpgagskaitaaeapgagsgsggsesvptgigpvstlhslhgkqgvtsvtch 578
Cdd:COG2319  296 FSPDGKLLASGSDDGTVRLWDL---------------------------------------------------------- 317

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  579 ggylySTGRdssyfQLFVHGGHLqpvlrqkacrgmNWVAGLRMVPDGSMVILGFHANEFVVWSPRSHEKLHIVNcggGHR 658
Cdd:COG2319  318 -----ATGK-----LLRTLTGHT------------GAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT---GHT 372


                 ....*....
gi 13878227  659 SW----AFS 663
Cdd:COG2319  373 GAvtsvAFS 381
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 741-1014 1.64e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 1.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  741 DIVITGSEDTTVCVLALPTTTgsahALTSVCNHISSVRALAVWAVGTpggpqdtrpgltaQVVSAGGRAEIHCFSVMVTP 820
Cdd:cd00200   22 KLLATGSGDGTIKVWDLETGE----LLRTLKGHTGPVRDVAASADGT-------------YLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  821 DASTpsrLACH---VMHLSSHRLDEY------------WDRQRNKHKMIKVDPETRYMSLAIceldndrpgLGPGPLVAA 885
Cdd:cd00200   85 CVRT---LTGHtsyVSSVAFSPDGRIlssssrdktikvWDVETGKCLTTLRGHTDWVNSVAF---------SPDGTFVAS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  886 ACSDGAVRLFLLqDSGRILHLLAesfHHKRCVLKVhSFTheaPNQRRrliLCSAATDGSLAFWDLTTamdkgsttlelpa 965
Cdd:cd00200  153 SSQDGTIKLWDL-RTGKCVATLT---GHTGEVNSV-AFS---PDGEK---LLSSSSDGTIKLWDLST------------- 208

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 13878227  966 hpglpyqmGTPSMTVQAHSCGVNSLHTLPTpegHHLVASGSEDGSLHVF 1014
Cdd:cd00200  209 --------GKCLGTLRGHENGVNSVAFSPD---GYLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
880-1083 3.20e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 3.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  880 GPLVAAACSDGAVRLFLLqDSGRILHLLAesfHHKRCVLKVhSFTheaPNQRRrliLCSAATDGSLAFWDLTTamdkgst 959
Cdd:COG2319  216 GKLLASGSADGTVRLWDL-ATGKLLRTLT---GHSGSVRSV-AFS---PDGRL---LASGSADGTVRLWDLAT------- 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  960 tlelpahpglpyqmGTPSMTVQAHSCGVNSLHTlpTPEGHHLvASGSEDGSLHVFTLAvkmpepeeaDGEaelvpQLCVL 1039
Cdd:COG2319  278 --------------GELLRTLTGHSGGVNSVAF--SPDGKLL-ASGSDDGTVRLWDLA---------TGK-----LLRTL 326

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 13878227 1040 EeysvpcAHAAHVTGVKIlSP--KLMVSASIDQRLTFWRLGQGEPT 1083
Cdd:COG2319  327 T------GHTGAVRSVAF-SPdgKTLASGSDDGTVRLWDLATGELL 365
WD40 COG2319
WD40 repeat [General function prediction only];
742-1077 8.26e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 8.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  742 IVITGSEDTTVCVLALPTTTgsahALTSVCNHISSVRALA------------------VWAVGTpGGPQDTRPGLTAQVV 803
Cdd:COG2319  134 TLASGSADGTVRLWDLATGK----LLRTLTGHSGAVTSVAfspdgkllasgsddgtvrLWDLAT-GKLLRTLTGHTGAVR 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  804 SAggraeihCFSvmvtPDASTpsrlachvmhLSSHRLDEY---WDRQRNKHKMIKVDPETRYMSLAIcelDNDrpglgpG 880
Cdd:COG2319  209 SV-------AFS----PDGKL----------LASGSADGTvrlWDLATGKLLRTLTGHSGSVRSVAF---SPD------G 258

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  881 PLVAAACSDGAVRLFLLqDSGRILHLLAesfHHKRCVLKVhSFTheaPNQRRrliLCSAATDGSLAFWDLTTamdkgstt 960
Cdd:COG2319  259 RLLASGSADGTVRLWDL-ATGELLRTLT---GHSGGVNSV-AFS---PDGKL---LASGSDDGTVRLWDLAT-------- 319

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  961 lelpahpglpyqmGTPSMTVQAHSCGVNSLHTlpTPEGHHLvASGSEDGSLHVFTLAvkmpepeeaDGEaelvpQLCVLE 1040
Cdd:COG2319  320 -------------GKLLRTLTGHTGAVRSVAF--SPDGKTL-ASGSDDGTVRLWDLA---------TGE-----LLRTLT 369

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 13878227 1041 eysvpcAHAAHVTGVKIlSP--KLMVSASIDQRLTFWRL 1077
Cdd:COG2319  370 ------GHTGAVTSVAF-SPdgRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
880-1082 1.06e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.22  E-value: 1.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  880 GPLVAAACSDGAVRLFLLqDSGRILHLLAesfHHKRCVLKVhSFtheAPNQRRrliLCSAATDGSLAFWDLTTamdkgst 959
Cdd:COG2319  174 GKLLASGSDDGTVRLWDL-ATGKLLRTLT---GHTGAVRSV-AF---SPDGKL---LASGSADGTVRLWDLAT------- 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  960 tlelpahpglpyqmGTPSMTVQAHSCGVNSLHTlpTPEGHHLvASGSEDGSLHVFTLAvkmpepeeaDGEAELVPQlcvl 1039
Cdd:COG2319  236 --------------GKLLRTLTGHSGSVRSVAF--SPDGRLL-ASGSADGTVRLWDLA---------TGELLRTLT---- 285

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 13878227 1040 eeysvpcAHAAHVTGVKIlSP--KLMVSASIDQRLTFWRLGQGEP 1082
Cdd:COG2319  286 -------GHSGGVNSVAF-SPdgKLLASGSDDGTVRLWDLATGKL 322
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 116-284 2.92e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 2.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  116 SDWIWDVRWIEGN--VAVALGHNSVVLYDPVIGcmlqdvPCTDRCT-----LSSACLVGDtwkELTIVAGAVSNELLIWy 188
Cdd:cd00200  135 TDWVNSVAFSPDGtfVASSSQDGTIKLWDLRTG------KCVATLTghtgeVNSVAFSPD---GEKLLSSSSDGTIKLW- 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  189 pataltDNKPVAPDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRLWKVGDLRVpggrvqnIGHCFGHSARVWQVKLLE 268
Cdd:cd00200  205 ------DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC-------VQTLSGHTNSVTSLAWSP 271

                        170
                 ....*....|....*...
gi 13878227  269 --NYLISAGEDCVCLVWS 284
Cdd:cd00200  272 dgKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 880-1014 2.72e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 2.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  880 GPLVAAACSDGAVRLFLLqDSGRILHLLAEsfhHKRCVLKVHSFTHeapnqrrRLILCSAATDGSLAFWDLTTamdkgst 959
Cdd:cd00200  189 GEKLLSSSSDGTIKLWDL-STGKCLGTLRG---HENGVNSVAFSPD-------GYLLASGSEDGTIRVWDLRT------- 250

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 13878227  960 tlelpahpglpyqmGTPSMTVQAHSCGVNSLHTLPTPeghHLVASGSEDGSLHVF 1014
Cdd:cd00200  251 --------------GECVQTLSGHTNSVTSLAWSPDG---KRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
874-1082 9.87e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.98  E-value: 9.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  874 RPGLGPGPLVAAACSDGAVRLFLLQDSGRILHLLAESFHHKRCVLKVHSFTHEAPNQRRRLILCSAATDGSLAFWDLTTa 953
Cdd:COG2319   31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT- 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13878227  954 mdkgsttlelpahpglpyqmGTPSMTVQAHSCGVNSLHTlpTPEGHHLvASGSEDGSLHVFTLavkmpepeeADGEaelv 1033
Cdd:COG2319  110 --------------------GLLLRTLTGHTGAVRSVAF--SPDGKTL-ASGSADGTVRLWDL---------ATGK---- 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 13878227 1034 pQLCVLEeysvpcAHAAHVTGVKIlSP--KLMVSASIDQRLTFWRLGQGEP 1082
Cdd:COG2319  154 -LLRTLT------GHSGAVTSVAF-SPdgKLLASGSDDGTVRLWDLATGKL 196
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 201-237 2.16e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.16e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 13878227     201 PDRRVSGHVGVIFSMSYLESKGLLATASEDRSVRLWK 237
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
287-325 3.34e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 3.34e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 13878227    287 GEILQAFRGHRGrGIRAIATHERQAWVVTGGDDSGIRLW 325
Cdd:pfam00400    1 GKLLKTLEGHTG-SVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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