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Conserved domains on  [gi|13752579|ref|NP_112542|]
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interleukin-23 subunit alpha precursor [Mus musculus]

Protein Classification

IL23 domain-containing protein( domain architecture ID 11244618)

IL23 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL23 super family cl25020
Interleukin 23 subunit alpha; This family, interleukin 23 subunit alpha, is a heterodimer ...
 28-185 1.88e-102

Interleukin 23 subunit alpha; This family, interleukin 23 subunit alpha, is a heterodimer consisting of a 40 kDa subunit - p40 - that is shared with IL12 and a unique 19 kDa subunit - p19. IL23 is a pro-inflammatory cytokine that binds to adnectins and thus plays a key role in the pathogenesis of several autoimmune and inflammatory diseases. IL23 signalling on the cell membrane works through the interaction of four proteins, two of which are shared with the IL12-receptor complex; signalling through the cell membrane involves the combined aggregation of at least two receptor components and then the subsequent activation of the Jak/Tyk tyrosine kinases and the family of STAT transcription factors.


The actual alignment was detected with superfamily member pfam16649:

Pssm-ID: 465217  Cd Length: 158  Bit Score: 291.87  E-value: 1.88e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13752579    28 PDWAQCQQLSRNLCMLAWNAHAPAGHMNLLREEEDEETKNNVPRIQCEDGCDPQGLKDNSQFCLQRIRQGLAFYKHLLDS 107
Cdd:pfam16649   1 PAWTQCQQLSQKLCTLAWSAHPPVGHMDLPREEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIRQGLVFYEKLLGS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13752579   108 DIFKGEPALLPDSPMEQLHTSLLGLSQLLQPEDHPRETQQMPSLSSSQQWQRPLLRSKILRSLQAFLAIAARVFAHGA 185
Cdd:pfam16649  81 DIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGA 158
 
Name Accession Description Interval E-value
IL23 pfam16649
Interleukin 23 subunit alpha; This family, interleukin 23 subunit alpha, is a heterodimer ...
 28-185 1.88e-102

Interleukin 23 subunit alpha; This family, interleukin 23 subunit alpha, is a heterodimer consisting of a 40 kDa subunit - p40 - that is shared with IL12 and a unique 19 kDa subunit - p19. IL23 is a pro-inflammatory cytokine that binds to adnectins and thus plays a key role in the pathogenesis of several autoimmune and inflammatory diseases. IL23 signalling on the cell membrane works through the interaction of four proteins, two of which are shared with the IL12-receptor complex; signalling through the cell membrane involves the combined aggregation of at least two receptor components and then the subsequent activation of the Jak/Tyk tyrosine kinases and the family of STAT transcription factors.


Pssm-ID: 465217  Cd Length: 158  Bit Score: 291.87  E-value: 1.88e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13752579    28 PDWAQCQQLSRNLCMLAWNAHAPAGHMNLLREEEDEETKNNVPRIQCEDGCDPQGLKDNSQFCLQRIRQGLAFYKHLLDS 107
Cdd:pfam16649   1 PAWTQCQQLSQKLCTLAWSAHPPVGHMDLPREEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIRQGLVFYEKLLGS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13752579   108 DIFKGEPALLPDSPMEQLHTSLLGLSQLLQPEDHPRETQQMPSLSSSQQWQRPLLRSKILRSLQAFLAIAARVFAHGA 185
Cdd:pfam16649  81 DIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGA 158
IL6 smart00126
Interleukin-6 homologues; Family includes granulocyte colony-stimulating factor (G-CSF) and ...
 59-180 7.45e-04

Interleukin-6 homologues; Family includes granulocyte colony-stimulating factor (G-CSF) and myelomonocytic growth factor (MGF). IL-6 is also known as B-cell stimulatory factor 2.


Pssm-ID: 128431  Cd Length: 154  Bit Score: 38.53  E-value: 7.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13752579     59 EEEDE---ETKNNVPRIQCEDGCDPQGLkdNSQFCLQRIRQGLAFYKHLLD--SDIFKGEPALLPdspMEQLHTSLLGLS 133
Cdd:smart00126  23 ENSEEalaENNLKLPKMNEKDGCFQSGF--NQEICLVKITAGLLEYQVYLEylQNEFPENKENVD---TLQLDTKTLIQI 97

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 13752579    134 QLLQPED-------HPRETQQ-MPSLSSSQQWQRPLLRSKILRSLQAFLAIAARV 180
Cdd:smart00126  98 IQQEMKDlgkitypTPTANRGlLPKLQSQNQWVRNATGFLILSSLERFLQFALRA 152
 
Name Accession Description Interval E-value
IL23 pfam16649
Interleukin 23 subunit alpha; This family, interleukin 23 subunit alpha, is a heterodimer ...
 28-185 1.88e-102

Interleukin 23 subunit alpha; This family, interleukin 23 subunit alpha, is a heterodimer consisting of a 40 kDa subunit - p40 - that is shared with IL12 and a unique 19 kDa subunit - p19. IL23 is a pro-inflammatory cytokine that binds to adnectins and thus plays a key role in the pathogenesis of several autoimmune and inflammatory diseases. IL23 signalling on the cell membrane works through the interaction of four proteins, two of which are shared with the IL12-receptor complex; signalling through the cell membrane involves the combined aggregation of at least two receptor components and then the subsequent activation of the Jak/Tyk tyrosine kinases and the family of STAT transcription factors.


Pssm-ID: 465217  Cd Length: 158  Bit Score: 291.87  E-value: 1.88e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13752579    28 PDWAQCQQLSRNLCMLAWNAHAPAGHMNLLREEEDEETKNNVPRIQCEDGCDPQGLKDNSQFCLQRIRQGLAFYKHLLDS 107
Cdd:pfam16649   1 PAWTQCQQLSQKLCTLAWSAHPPVGHMDLPREEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIRQGLVFYEKLLGS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 13752579   108 DIFKGEPALLPDSPMEQLHTSLLGLSQLLQPEDHPRETQQMPSLSSSQQWQRPLLRSKILRSLQAFLAIAARVFAHGA 185
Cdd:pfam16649  81 DIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGA 158
IL6 pfam00489
Interleukin-6/G-CSF/MGF family;
64-179 3.35e-04

Interleukin-6/G-CSF/MGF family;


Pssm-ID: 395393  Cd Length: 184  Bit Score: 39.84  E-value: 3.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13752579    64 ETKNNVPRIQCEDGCDPQGLkdNSQFCLQRIRQGLAFYKHLLD--SDIFKGEPAllpDSPMEQLHTSLLGLSQLLQPEDH 141
Cdd:pfam00489  60 ENNLNLPKMAEKDGCFQSGF--NQETCLMKITTGLLEFQIYLDylQNKFEGNKE---NAKVLQRSTKTLVQILKQKVKNP 134

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 13752579   142 PRETQQMP----SLSSSQQWQRPLLRSK----ILRSLQAFLAIAAR 179
Cdd:pfam00489 135 HEITTPDPttnaSLLAKLQSQNEWLKNTtihlILRSLEDFLQFSLR 180
IL6 smart00126
Interleukin-6 homologues; Family includes granulocyte colony-stimulating factor (G-CSF) and ...
 59-180 7.45e-04

Interleukin-6 homologues; Family includes granulocyte colony-stimulating factor (G-CSF) and myelomonocytic growth factor (MGF). IL-6 is also known as B-cell stimulatory factor 2.


Pssm-ID: 128431  Cd Length: 154  Bit Score: 38.53  E-value: 7.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13752579     59 EEEDE---ETKNNVPRIQCEDGCDPQGLkdNSQFCLQRIRQGLAFYKHLLD--SDIFKGEPALLPdspMEQLHTSLLGLS 133
Cdd:smart00126  23 ENSEEalaENNLKLPKMNEKDGCFQSGF--NQEICLVKITAGLLEYQVYLEylQNEFPENKENVD---TLQLDTKTLIQI 97

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 13752579    134 QLLQPED-------HPRETQQ-MPSLSSSQQWQRPLLRSKILRSLQAFLAIAARV 180
Cdd:smart00126  98 IQQEMKDlgkitypTPTANRGlLPKLQSQNQWVRNATGFLILSSLERFLQFALRA 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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