|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
35-494 |
0e+00 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 615.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 35 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 114
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 115 GWVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAM 194
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 195 FIQGALSLNLCVCGALMRplspeklencpeaeepcalpaystesvksggplgmaeeqdrrpgneemvcdlqtqecqgqth 274
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 275 prknvcafrvlktvsqltvqvrrgfrdwhsgyfgtasLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVSLYNLSEQNDT 354
Cdd:cd17429 179 -------------------------------------LFTNKVFVAFIFWALFAYCSFVIPFIHLPEIVKLYGLSEQNDK 221
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 355 FPLTSIIAILHIFGKVILGAVADLPCISVWNVFLIANFTLVLSIFLLPLMHTYASLAVICALIGFSSGYFSLMPVVTEDL 434
Cdd:cd17429 222 FPLTSIIAIVHIFGKVILGIICDLPCISVWNVFILANFTLGVCILILPLMHTYTGLAIVCALIGFSSGYFSLMPVVTEDL 301
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 435 VGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLLIQP 494
Cdd:cd17429 302 VGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIICLLLKP 361
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
35-494 |
1.01e-110 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 332.98 E-value: 1.01e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 35 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 114
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 115 GWVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAM 194
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 195 FIQGALSLNLCVCGALMRplspeklencpeaeepcalpaystesvksggplgmaeeqdrrpgneemvcdlqtqecqgqth 274
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 275 prknvcafrvlktvsqltvqvrrgfrdwhsgyfgtasLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVSLYNLSEQnDT 354
Cdd:cd17352 179 -------------------------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDES-DA 220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 355 FPLTSIIAILHIFGKVILGAVADLPCISVWNVFLIANFTLVLSIFLLPLMHTYASLAVICALIGFSSG-YFSLMPVVTED 433
Cdd:cd17352 221 AFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGsYSSLTPVILAD 300
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41281606 434 LVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLLIQP 494
Cdd:cd17352 301 LVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
36-492 |
2.76e-62 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 207.75 E-value: 2.76e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 36 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLG 115
Cdd:cd17428 2 WVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAGG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 116 WVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMF 195
Cdd:cd17428 82 LMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 196 IQGALSLNLCVCGALMRplspeklencpeaeepcalpaystesvksggplgmaeeqdrrpgneemvcdlqtqecqgqthp 275
Cdd:cd17428 162 IVGALALNLLACGSLMR--------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 276 rknvcafrvlktvsqltvqvrrgfrdwhsgyfgtasLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVSLYNLSEQNDTF 355
Cdd:cd17428 179 ------------------------------------LFKNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIEEIALI 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 356 PLTSIIAILHIFGKVILGAVADLPCISVWNVFLIANFTLVLSIFLLPLMHTYASLAVICALIGFSSGYFSLMPVVTEDLV 435
Cdd:cd17428 223 PLVSIIGITTAIGKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWSIFPYVTTKTV 302
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 41281606 436 GTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLLI 492
Cdd:cd17428 303 GIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLLL 359
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
26-492 |
5.50e-59 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 201.89 E-value: 5.50e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 26 PHPDIDGGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTA 105
Cdd:TIGR00892 8 EGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVV 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 106 IIGGLVNSLGWVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLC 185
Cdd:TIGR00892 88 IAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 186 AEYGWRNAMFIQGALSLNLCVCGALMRPLSPEKLENCPEAEEpCALPAYSTesvKSGGPLGMAEEQDRrpgneemvcdlq 265
Cdd:TIGR00892 168 ESFGWRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKSKE-GLPPDGST---KKLSKKSTAEKINR------------ 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 266 tqecqgqthprknvcafrvlktvsqltvqvrrgFRDWhsgyfgtaSLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVSL 345
Cdd:TIGR00892 232 ---------------------------------FLDF--------SLFTHRGFLVYLSGNVIMFLGFFAPIIFLVPYAKD 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 346 YNLSEQNDTFpLTSIIAILHIFGKVILGAVADLPCIS--VWNVFLIANFTLVLSIFLLPLMHTYASLAVICALIGFSSGY 423
Cdd:TIGR00892 271 KGVDEYEAAF-LLSIIGFVDIFARPSCGLIAGLKWIRphVQYLFSFALLFNGLTHLLCALAGDYTGLVIYCIFFGLSFGS 349
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 424 F-SLMPVVTEDLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLLI 492
Cdd:TIGR00892 350 VgALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAGLFLAI 419
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
36-494 |
2.32e-56 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 192.61 E-value: 2.32e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 36 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLG 115
Cdd:cd17423 2 WVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 116 WVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMF 195
Cdd:cd17423 82 FLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 196 IQGALSLNLCVCGALMRPLSPEKLENCPEAEEPCAlpaystesvksggplgmaeeqdrrpgneemvcdlqtqecqgqthp 275
Cdd:cd17423 162 LLSALSLHLVPCGALLRPLALPGDPPAPPRSLSAA--------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 276 rknvcafrvlktvsqltvqvrrgfrdwhsgyFGTaSLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVSLYNLSEQNDTF 355
Cdd:cd17423 197 -------------------------------FGL-SLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEYQAAF 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 356 pLTSIIAILHIFGKVILGAVADLPCISVWNVFLIANFTLVLSIFLLPLMHTYASLAVICALIGFSSGyfSLMPV---VTE 432
Cdd:cd17423 245 -VVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAG--ALAPLvfsVLP 321
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41281606 433 DLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLLIQP 494
Cdd:cd17423 322 ELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLILLTLP 383
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
36-490 |
1.28e-47 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 168.84 E-value: 1.28e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 36 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLG 115
Cdd:cd17424 2 WMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLASTG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 116 WVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMF 195
Cdd:cd17424 82 LILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 196 IQGALSLNLCVCGALMRPLSPEKlencpeaeepcalpaystesvksggplgmaeeqdrrpgneemvcdlqtqecqgqthp 275
Cdd:cd17424 162 ILGGFVLNLCVCGALMRFLLMPD--------------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 276 rknvcafrvlktvsqltvqvrrgfrdwhsgyfgtaslftnrmFVAFIFWALFAYSSFVIPFIHLPEIVSLYNLSEQNDTF 355
Cdd:cd17424 185 ------------------------------------------FLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAF 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 356 pLTSIIAILHIFGKVILGAVADLPCISVWN--VFLIANFTLVLSIFLLPLMHTYASLAVICALIG-FSSGYFSLMPVVTE 432
Cdd:cd17424 223 -LMSILGVIDIIGNITFGWLTDRRCLKKYRyfCYLFAVGMDGLCCLFLPILKTFPLLVPFSFTFGyFDGAYVALIPVVTS 301
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 41281606 433 DLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFL 490
Cdd:cd17424 302 DVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLL 359
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
36-491 |
1.22e-43 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 158.73 E-value: 1.22e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 36 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLG 115
Cdd:cd17314 2 WFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 116 WVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMF 195
Cdd:cd17314 82 YTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 196 IQGALSLNLCVCGALMRPLSPeklencpeaeepcalpaystesvksggplgmaeeqdrrpgneemvcdlqtQECQGQTHP 275
Cdd:cd17314 162 ILGILAAIVLSVVSLLGFKEP--------------------------------------------------PDNQARLHV 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 276 RKNVCAFRVlktvsqltvqvrrgfrdwhsgyfgtaslftnRMFVAFIFWALF-AYSSFVIPF----IHLPEIVSLYNLSE 350
Cdd:cd17314 192 QKKKTQTMG-------------------------------EIFRDKVFWILFiAIFLVLIGGflfiANMASLVRSLQLDA 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 351 QNDTFPLTSIIAILHIFGKVILGAVADL---PCISVWNVFLIAnfTLVLSIFLLPLMHTYASLAVICALIGFS-SGYFSL 426
Cdd:cd17314 241 PSFVTKLMSIYGLFNAFGRLLWGIVADFfggRLSTLSILLTIL--GLGLCAFLFLLKMTPVGLVLTGSLLGFSyGGLFTV 318
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41281606 427 MPVVTEDLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLL 491
Cdd:cd17314 319 YPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILL 383
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
36-490 |
1.02e-42 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 155.68 E-value: 1.02e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 36 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLG 115
Cdd:cd17422 2 WAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 116 WVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMF 195
Cdd:cd17422 82 MITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 196 IQGALSLNLCVCGALMRPLspeklencpeaeepcalpaystesvksggplgmaeeqdRRPGneemvcdlqtqecqgqthp 275
Cdd:cd17422 162 VVGALQLNIVVCGALLRVL--------------------------------------KEPG------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 276 rknvcafrvlktvsqltvqvrrgfrdwhsgyfgtaslftnrmFVAFIFWALFAYSSFVIPFIHLPEIVSLYNLSEQNDTF 355
Cdd:cd17422 185 ------------------------------------------FICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAAY 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 356 PLtSIIAILHIFGKVILGAVADLPCISVWNVFLIANFTLVLSIFLLPLMHTYASLAVICALIGFSSGYF--SLMPVVTE- 432
Cdd:cd17422 223 ML-SAMAIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVagTHIPLLAEd 301
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 41281606 433 DLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFL 490
Cdd:cd17422 302 DVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFL 359
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
35-492 |
2.42e-41 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 151.85 E-value: 2.42e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 35 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 114
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 115 GWVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAM 194
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 195 FIQGALSLNLCVCGALMRPlspeklencpeaeepcalpaystesvksggplgmaeeqdrrpgneemvcdlqtqecqgqth 274
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP------------------------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 275 prknvcafrvlktvsqltvqvrrgfrdwhsgyfgtasLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVSLYNLSEQNDT 354
Cdd:cd17425 180 -------------------------------------FCSNTRYQIYTLGVTWMVLGFVLPLIYLVPYATSNGMDESKAA 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 355 FpLTSIIAILHIFGKVILGAVADLPCISVWNVFLIANFTLV--LSIFLLPLMHTYASLAVICALIGFS-SGYFSLMPVVT 431
Cdd:cd17425 223 L-LLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLngLSNLICAISASFPVLLVYCLLYSISmSGIGSLIFQVL 301
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41281606 432 EDLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLLI 492
Cdd:cd17425 302 MDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALFMGL 362
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
35-492 |
4.44e-39 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 146.03 E-value: 4.44e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 35 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 114
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 115 GWVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAM 194
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 195 FIQGALSLNLCVCGALMRPLspeklencpeaeepcalpaystesvksggplgmaeeqdrrpgneemvcDLqtqecqgqth 274
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRPL------------------------------------------------DF---------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 275 prknvcafrvlktvsqltvqvrrgfrdwhsgyfgtaSLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVSLYNLSEQNDT 354
Cdd:cd17430 183 ------------------------------------SVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAA 226
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 355 FpLTSIIAILHIFGKVILGAVADLPCISVWNVFLIAnFTLV---LSIFLLPLMHTYASLAVICALIGFSSGYF-SLMPVV 430
Cdd:cd17430 227 F-LLSILGFIDIFARPACGVVAGLKWVRPRVVYLFS-FAMLfngLTDLCSATAADYGGLVVFCVFFGISYGMVgALQFEV 304
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41281606 431 TEDLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLLI 492
Cdd:cd17430 305 LMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALFLAL 366
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
35-491 |
5.28e-38 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 143.82 E-value: 5.28e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 35 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEF-----HQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGG 109
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLtklgdPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 110 LVNSLGWVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYG 189
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 190 WRNAMFIQGALSLNLCVCGALMRPLSPeklencpeaeepcalpaySTESVKSGGplgmaeeqdrrpgneemvcdlqtqec 269
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHP------------------SPEDPKSKP-------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 270 QGQTHPRKnvcAFRVLKTVSQLTVQVRRGFRDWHSGyfgtaslftnrmfvafIFWALFAYssfVIPFIHLPEIVSLYNLS 349
Cdd:cd17420 197 GRRTLHSR---INLFLRKIFNVEIFKRKRYVIWALG----------------IPLALFGY---FVPYVHLMKFVKEEFFP 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 350 EQNDTFPLTSiIAILHIFGKVILGAVADLPcISVWNVFL--IANFTLVLSIFLLPLMHTYASLAVICALIGFSSGYF-SL 426
Cdd:cd17420 255 GKDVNVPLMC-IGITSGIGRLIFGVIADMP-PGVKKMYLqvLSFVSIGLMSMMIPLCNSFGILISVCLVMGLFDGCFiSI 332
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41281606 427 MPVVTEDLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVG--ILFLL 491
Cdd:cd17420 333 MAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGssLLFFI 399
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
35-494 |
2.90e-36 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 138.03 E-value: 2.90e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 35 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 114
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 115 GWVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFgTFLMTVLLKYLCAEYGWRNAM 194
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGL-TFALAPFTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 195 FIQGALSLNLCVCGALMRPLSpeklencpeaeepcalpaystesvksggplgmaeeqdrrpgneemvcdlqtqecqgqth 274
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPID----------------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 275 prknvcafrvlktvsqltvqvrrgfrdwhsgyfgtASLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVSLYNLSEQNDT 354
Cdd:cd17421 181 -----------------------------------FSLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARTLGIDPMDAS 225
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 355 FpLTSIIAILHIFGKVILGAVADLPCISVWNVFLIANFTLVLSIFLLPLMHTYASLAV--ICALIgFSSGYFSLMPVVTE 432
Cdd:cd17421 226 F-IISVAGITETVAQLASGWIADQNWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTyaVFFAI-FCGGYLALLLPVLV 303
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41281606 433 DLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLLIQP 494
Cdd:cd17421 304 DLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVSFFLEP 365
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
36-492 |
2.05e-34 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 133.01 E-value: 2.05e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 36 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLG 115
Cdd:cd17427 2 WAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 116 WVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMF 195
Cdd:cd17427 82 MISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 196 IQGALSLNLCVCGALMRPLSPeklencpeaeepcalpaystesvksggplgmaeeqdrrpgneemvcdlqtqecqgqthp 275
Cdd:cd17427 162 ILGGLLLNCCVAGSLMRPLGP----------------------------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 276 rknvcafrvlktvsqltvqvrrgfrdwhsgyfgtasLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVSLYNLSEQNDTF 355
Cdd:cd17427 183 ------------------------------------LFKHRGFLIYLSGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAAF 226
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 356 pLTSIIAILHIFGKVILGAVADLPCI--SVWNVFLIANFTLVLSIFLLPLMHTYASLAVICALIGFSSGYFSLMPVVT-E 432
Cdd:cd17427 227 -LLSILAFVDMFARPSMGLVANSKWIrpRIQYFFSFAVMYNGVCHLLCPLAEDYTGLVIYAVFFGFAFGMVSSVLFETlM 305
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 433 DLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLLI 492
Cdd:cd17427 306 DLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIWLFI 365
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
36-494 |
4.26e-34 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 132.61 E-value: 4.26e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 36 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEF-----HQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGL 110
Cdd:cd17464 2 WVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFgskddAQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 111 VNSLGWVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGW 190
Cdd:cd17464 82 VGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 191 RNAMFIQGALSLNLCVCGALMRPLSPEKLencpeaeepcalpaystesvksggplgmaeeqdrrpgneemvcDLQTQECQ 270
Cdd:cd17464 162 FNTLRVLCIFMFVLFLAGFTYKPLVPMKK-------------------------------------------DKEGKKRK 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 271 GQTHPRKNVCAFRVLKTvsqltvqvrRGFRDWHSGyfgtaslftnrmfvafIFWALFAYssfVIPFIHLPEIVSLYNLSE 350
Cdd:cd17464 199 FKCPPLKKIFNFNIWKS---------TGYRIWAFG----------------IPAALFGY---FVPYVHLMNHVKERFGED 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 351 QNDTFpLTSIIAILHIFGKVILGAVAD-LPCISVWNVFLIANFTLVLSIFLLPLMHTYASLAVICALIGFSSGYF-SLMP 428
Cdd:cd17464 251 VNKEV-LLMCIGITSGIGRLIFGRVADyIPGVKKVYLQVSSFFFIGLMSMMIPLCHVFGGLIAVCLFMGLFDGCFiSIMA 329
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41281606 429 VVTEDLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLLIQP 494
Cdd:cd17464 330 PIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPIIGGIILCFIP 395
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
35-492 |
1.63e-33 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 130.81 E-value: 1.63e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 35 AWMMVLSSFFVHiLIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 114
Cdd:cd17353 2 RWLVLLGAVLMH-LILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 115 GWVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAM 194
Cdd:cd17353 81 GFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 195 FIQGALSLNL-CVCGALMRPlspeklencpeaeepcALPAYSTESVKSGGPLGMAEEQDRRPgnEEMVCDLQtqecqgqt 273
Cdd:cd17353 161 LILGIIFLIIiVIGAFLIRD----------------PPKGWVPPGVDPLANNAENSPRDYTP--REMLRTPT-------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 274 hprknvcaFRVLktvsqltvqvrrgfrdwhsgYFgtaslftnrMFVAFIFWALFAYSS---FVIPFIHL-PEIVSLynls 349
Cdd:cd17353 215 --------FWLL--------------------WL---------MFFLNATAGLMLIGQakpIGQEFAGLdAGIAAL---- 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 350 eqndtfpLTSIIAILHIFGKVILGAVADLpcISVWNVFLIAN-FTLVLSIFLLPLMHTYASLAVICALIGFSSG-YFSLM 427
Cdd:cd17353 254 -------AVSILSIFNGGGRPFWGWLSDK--IGRKNTLSIAFlIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGgGFALF 324
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41281606 428 PVVTEDLVGTEHLANAYGIIICANGISALLGPPFAGWiFDITQKYDFSFYICGLLYMVGILFLLI 492
Cdd:cd17353 325 PALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAY-VLYTGGYNAAFIIAAALSLVALALALL 388
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
35-492 |
1.36e-32 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 128.46 E-value: 1.36e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 35 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 114
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 115 GWVLSAYAANVqSLFITFGVAAGLGSGMAYLPAVVMVGRYF-QKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNA 193
Cdd:COG2223 83 GLLLLALAVSY-WLLLLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 194 MFIQGALSLNLCVCGALMrplspekLENCPEAEEPcalpaystesvksggplgmaeeqdrrpgneemvcdlqtqecqgqt 273
Cdd:COG2223 162 FLILGILLLVVAVLAWLF-------LRDPPAGAAA--------------------------------------------- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 274 hprknvcafrvlkTVSQLTVQVRRGFRDWHSGYFGtaslftnrMFVAFIFWALFAYSSFVIPFihlpeIVSLYNLSeQND 353
Cdd:COG2223 190 -------------AAKASLRDQLEALRDPRFWLLS--------LLYFGTFGSFIGFSSWLPPY-----LVDQFGLS-AAT 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 354 TFPLTSIIAILHIFGKVILGAVADLpcISVWNVFLIANFTLVLSIFLLPLMHTYASLAVICALI--GFSSGYFSLMPVVT 431
Cdd:COG2223 243 AGLLAALFALLGALGRPLGGWLSDR--IGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLlgLALGGGNGAVFALV 320
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41281606 432 EDLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLLI 492
Cdd:COG2223 321 PDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
67-492 |
3.17e-31 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 124.22 E-value: 3.17e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 67 FHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVQSLFITFGVAAGLGSGMAYLP 146
Cdd:cd17426 33 FNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGAGLIAASFCNTVEGLYFCVGVVGGLGLAFNLNP 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 147 AVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMFIQGALSLNLCVCGALMRPLSPEKlencpeae 226
Cdd:cd17426 113 ALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSFLILGGLLLNCCVAGSLMRPIGPKP-------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 227 epcalpaystesvksggplgmaeeqdrrpgneemvcdlqtqecqgqthprknvcafrvlktvsqltvqvrrgfrdwhsgy 306
Cdd:cd17426 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 307 FGTASLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVSLYNLSEQNDTFpLTSIIAILHIFGKVILGAVADLPCI--SVW 384
Cdd:cd17426 185 FLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNESAAF-LLSILAFVDMVARPSMGIVANTKWVrpRIQ 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 385 NVFLIANFTLVLSIFLLPLMHTYASLAVICALIGFSSGYFSLMPVVT-EDLVGTEHLANAYGIIICANGISALLGPPFAG 463
Cdd:cd17426 264 YFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFAFGWLSSVLFETlMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLG 343
|
410 420
....*....|....*....|....*....
gi 41281606 464 WIFDITQKYDFSFYICGLLYMVGILFLLI 492
Cdd:cd17426 344 RLNDIYGDYKYTYWACGIVLIISSIYLFI 372
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
32-492 |
1.18e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 108.03 E-value: 1.18e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 32 GGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLV 111
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 112 NSLGWVLSAYAANVQSLFITFgVAAGLGSGMAYLPAVVMVGRYF-QKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGW 190
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 191 RNAMFIQGALSLnlcvcgalmrplspeklencpeaeepcalpaystesvksggplgmaeeqdrrpgneemvcdlqtqecq 270
Cdd:COG2271 164 RAAFLILGLPGL-------------------------------------------------------------------- 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 271 gqthprknvcafrvlktvsqltvqvrrgfrdwhsgYFGTASLFTNRMFVAFIFWALFAYSSFVIPFihlpeIVSLYNLSE 350
Cdd:COG2271 176 -----------------------------------LLALLRFWLLALAYFLVYFALYGFLTWLPTY-----LVEVRGLSL 215
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 351 QnDTFPLTSIIAILHIFGKVILGAVADLPCISVWNVFLIANFTLVLSIFLLPLMHTYASLAVICALIGF-SSGYFSLMPV 429
Cdd:COG2271 216 A-QAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFgLGGAFGLLWA 294
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41281606 430 VTEDLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQkYDFSFYICGLLYMVGILFLLI 492
Cdd:COG2271 295 LAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALL 356
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
35-491 |
2.30e-25 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 107.74 E-value: 2.30e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 35 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 114
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 115 GWVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMV-GRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNA 193
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVaAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 194 MFIQGALSLNLCV-CGALMRPLSPEKlencPEAEEPCALPAYSTESVKSggplgmaeeqdrrpgneemvcdlqtqecqgq 272
Cdd:cd17355 161 LLVLALLALLVLVpVLLLLRRRPADL----ALRAYDDASPASPGSTLKE------------------------------- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 273 thprknvcAFRvlktvsqltvqvRRGFRdwhsgyfgtaslftnRMFVAFIFwALFAYSSFVipfIHLPEIVSLYNLSEQN 352
Cdd:cd17355 206 --------ALR------------SASFW---------------LLALAFFL-CGFAVVGLI---VHLVPYLADRGISPAA 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 353 DTFPLtSIIAILHIFGKVILGAVADLpcISVWNVFLIANFTLVLSIFLLPLMH-TYASLAVICALIGFSSG-YFSLMPVV 430
Cdd:cd17355 247 AAVAL-ALIGLFNIVGRLLSGWLGDR--YSPRRLLAASYALRALGLALLLLLPfPPLALLLFAALFGLGWGaTVPLTAAL 323
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41281606 431 TEDLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLL 491
Cdd:cd17355 324 AARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
36-494 |
1.13e-21 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 96.40 E-value: 1.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 36 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEF-----HQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGL 110
Cdd:cd17465 2 WVVVFAATWCNGSIFGIQNSFGILYVMLLNEQedqkdQAVQFKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 111 VNSLGWVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKylcaeygw 190
Cdd:cd17465 82 VAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLK-------- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 191 rnamfiqgalslnlcvcgalmrplspeklencpeaeepcalpaystesvKSGGPLGMAeeqdrrpgneemvcdlqtqecq 270
Cdd:cd17465 154 -------------------------------------------------MVGDAIGLA---------------------- 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 271 gqtHPRKNVCAFRVLKTVSQLTVQV--RRGFRDWHsgyFGTASlftnrmfvafifwalfAYSSFVIPFIHLPEIVSlYNL 348
Cdd:cd17465 163 ---HTFQVLSLFMFIQIFLSLTYKVfrRKTYRIWA---FGIAT----------------AVLGYFVPYVHLMKYVE-EEF 219
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 349 SEQNDTFPLTSIIAILHIFGKVILGAVADLpCISVWNVFL-IANFTL--VLSIfLLPLMHTYASLAVICALIGFSSGYF- 424
Cdd:cd17465 220 KENKREWVLLVCIGASSGIGRLMSGKIGDL-IPGLKKIYLqVASFLLlgIMSM-MIPLCQVFEGVIVVCLFLGLCDGCFi 297
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 425 SLMPVVTEDLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLLIQP 494
Cdd:cd17465 298 TIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIGGTVLFFVP 367
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
43-459 |
2.32e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 95.18 E-value: 2.32e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 43 FFVHILIMGSQMALGVLNVEWL-EEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAY 121
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 122 AANVQSLFItFGVAAGLGSGMAYLPAVVMVGRYFQK-RRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMFIQGAL 200
Cdd:pfam07690 82 ASSLWLLLV-LRVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 201 SLNLCVCGALMRPLSPEKlencpeaeepcalpaystesvksggplgmaeeqdrrpgneemvcdlqtqecqgqthprknvc 280
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESK-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 281 afrvlktvsqltvQVRRGFRDWHSGYFGTASLFTNRMFVAFIFWALFAySSFVIPFIHLPEIVSLYNLSEQNDTFPLtSI 360
Cdd:pfam07690 179 -------------RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFG-FAFFGLLTYLPLYQEVLGLSALLAGLLL-GL 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 361 IAILHIFGKVILGAVAD-LPCISVWNVFLIANFTLVLSIFLLPLMHTYASLAVICALIGFSSG-YFSLMPVVTEDLVGTE 438
Cdd:pfam07690 244 GGLLGAIGRLLLGRLSDrLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGlVFPALNALVSDLAPKE 323
|
410 420
....*....|....*....|.
gi 41281606 439 HLANAYGIIICANGISALLGP 459
Cdd:pfam07690 324 ERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
43-491 |
9.99e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 90.95 E-value: 9.99e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 43 FFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYA 122
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 123 ANVQSLFITFGVaAGLGSGMAYLPAVVMVGRYF-QKRRALAQGLSTTGTGFGTFLMTVLLKYL--CAEYGWRNAMFIQGA 199
Cdd:cd06174 82 PSFWLLLLGRFL-LGLGSGLIDPAVLALIADLFpERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 200 LSLNLCVCGALMRPLSPEKlencpeaeepcalpaystesvksggplgmaeeqdrrpgneemvcdlqtqecqgqthprknv 279
Cdd:cd06174 161 LALLAAILLLLVVPDPPES------------------------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 280 cafRVLKTVSQLTVQVRRGFRdwhsgyfgtaSLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVSLYNLSEQNDTFPLTS 359
Cdd:cd06174 180 ---ARAKNEEASSKSVLKLLK----------RVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLS 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 360 IIAILHIFGKVILGAVADLPcISVWNVFLIANFTLVLSIFLLPLMHTYASLAVICALIGFS-SGYFSLMPVVTEDLVGTE 438
Cdd:cd06174 247 LFGLAGALGSLLLGLLSDRL-IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGlGGLLPLSFALIAELFPPE 325
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 41281606 439 HLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLL 491
Cdd:cd06174 326 IRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
35-492 |
2.25e-18 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 87.24 E-value: 2.25e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 35 AWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 114
Cdd:COG2807 16 RWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 115 GWVLSAYAANVQSLFITFGVAaGLGSGMAYLPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAM 194
Cdd:COG2807 96 GLLLRSLAPSVALLLAGTALI-GAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 195 FIQGALSLNLCVCGALmrplspeklencpeaeepcalpaystesvksggplgmaeeqdrrpgneemvcdlqtqecqgqth 274
Cdd:COG2807 175 AVWALLALLALLLWLP---------------------------------------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 275 prknvcAFRVLKTVSQLTVQVRRGFRDWHSGYFGTASLFTnrMFVAFIFWALFAyssfvipfiHLPEIVSLYNLSEQNDT 354
Cdd:COG2807 191 ------LLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFF--GLQSLLYYAVVA---------WLPPILRDAGLSAATAG 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 355 FpLTSIIAILHIFGKVILGAVAD-LPCISVWNVFLIAnfTLVLSIFLLPLMHTyASLAVICALIGFSSG-YFSLMPVVTE 432
Cdd:COG2807 254 L-LLSLFQLAGIPGSLLVPLLADrLGDRRPLLLLLGL--LGLAGLLGLLLAPG-SLPWLWAVLLGLGQGgLFPLALTLIG 329
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41281606 433 DLVGT-EHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLLI 492
Cdd:COG2807 330 LRARTpAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLL 390
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
34-455 |
4.95e-15 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 76.55 E-value: 4.95e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 34 WAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNS 113
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 114 LGWVLSAYAANVQSLFItFGVAAGLGSGMAYLPAVVMVGRYF-QKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRN 192
Cdd:COG2814 87 LGSLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 193 AMFIQGALSLnlcVCGALMRPLSPEklencpeaeepcalpaystesvksggplgmaeeqdrrpgneemvcdlqtqecqgq 272
Cdd:COG2814 166 VFLVNAVLAL---LALLLLLRLLPE------------------------------------------------------- 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 273 thprknvcafrvlkTVSQLTVQVRRGFRDwhsgyfgtasLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVSLYNLSEQN 352
Cdd:COG2814 188 --------------SRPAARARLRGSLRE----------LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 353 DTFPLTSIIAILHIFGKVILGAVADLpcISVWNVFLIANFTLVLSIFLLPLMHTYASLAVICALIGFSSG-YFSLMPVVT 431
Cdd:COG2814 244 AAGLLLALFGLGGVLGALLAGRLADR--FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGlLFPLLQALV 321
|
410 420
....*....|....*....|....
gi 41281606 432 EDLVGTEHLANAYGIIICANGISA 455
Cdd:COG2814 322 AELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
36-492 |
5.46e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 57.97 E-value: 5.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 36 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLG 115
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 116 WVLSAYAANVQSLFItFGVAAGLGSGMAYLPAVVMVGRYF-QKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAM 194
Cdd:cd17319 82 TALTGFATSLTSLYV-LRFLLGVAEAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 195 FIQGALSLnlcvcgaLMRPLspeklencpeaeepcalpaystesvksggplgmaeeqdrrpgneemvcdlqtqecqgqth 274
Cdd:cd17319 161 IIEGLLGL-------LLAVL------------------------------------------------------------ 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 275 prknvcAFRVLKTVSQLTVqvrrgfrdwhsGYFGTASLFTnrmfvAFIFWalfayssfvIPFIhlpeIVSLYNLSEQNDT 354
Cdd:cd17319 174 ------WWFYLRQVWGLAL-----------GYFGINYALY-----GLLTW---------LPTY----LKQARGFSLKQVG 218
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 355 FpLTSIIAILHIFGKVILGAVAD--LPCISVWNVFLIANFTLVLSIFLLPLMHTYASLAVICALIGFSSGYFSLMPVVTE 432
Cdd:cd17319 219 L-LAAIPFLAGAIGMILGGRLSDrlLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPA 297
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 433 DLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLLI 492
Cdd:cd17319 298 DLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
317-492 |
3.15e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 55.37 E-value: 3.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 317 MFVAFIFWALFAYSSFVIPFIhLPEIVSLYNLSEQNDTFpLTSIIAILHIFGKVILGAVADLpcISVWNVFLIANFTLVL 396
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPA-LPLIAADLGASPAQAGL-VVTAYLLGAALGAPLAGRLADR--FGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 397 SIFLLPLMHTYASLAVICALIGFSSG-YFSLMPVVTEDLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQkYDFS 475
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWV 166
|
170
....*....|....*..
gi 41281606 476 FYICGLLYMVGILFLLI 492
Cdd:COG2814 167 FLVNAVLALLALLLLLR 183
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
317-492 |
6.07e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 54.73 E-value: 6.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 317 MFVAFIFWALFAYSSFVIPfihlPEIVSLYNLSEQNDTFpLTSIIAILHIFGKVILGAVADLpcISVWNVFLIANFTLVL 396
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALP----LLLAEDLGISPTEIGL-LLTLFSLGYALAQPLAGRLSDR--FGRRRVLLIGLLLFAL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 397 SIFLLPLMHTYASLAVICALIGF-SSGYFSLMPVVTEDLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQkYDFS 475
Cdd:pfam07690 75 GLLLLLFASSLWLLLVLRVLQGLgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAA 153
|
170
....*....|....*..
gi 41281606 476 FYICGLLYMVGILFLLI 492
Cdd:pfam07690 154 FLILAILSLLAAVLLLL 170
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
359-492 |
8.55e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.12 E-value: 8.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 359 SIIAILHIFGKVILGAVADLpcISVWNVFLIANFTLVLSIFLLPLMHTYASLAVICALIGFSSG--YFSLMPVVTeDLVG 436
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDR--IGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGlvFPATLALLA-DIVP 318
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 41281606 437 TEHLANAYGIIICANGISALLGPPFAGWIFDiTQKYDFSFYICGLLYMVGILFLLI 492
Cdd:cd17325 319 PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAAVLFLL 373
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
36-217 |
1.27e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 53.28 E-value: 1.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 36 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLG 115
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 116 WVLSAYAANVqSLFITFGVAAGLGSGMAYLPAVVMVGRYFQ-KRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRnAM 194
Cdd:COG0477 93 SLLCGLAPSP-ELLIAARALQGIGAGGLMPGALALIAELFPaRERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR-WI 170
|
170 180
....*....|....*....|...
gi 41281606 195 FIQGALslnLCVCGALMRPLSPE 217
Cdd:COG0477 171 FLINAP---LGLLALVLRLRLPE 190
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
319-492 |
2.07e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 52.96 E-value: 2.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 319 VAFIFWALFAYSSFVIPFihLPEIVSLYNLSEQndtfpLTSIIAILH----IFGKVILGAVADLpcISVWNVFLIANFTL 394
Cdd:cd17325 1 LSLALFLDMLGYGIIIPI--LPLYAESLGASVA-----QIGLIVAAYalaqLLFSPPAGRLSDR--FGRKRLLLLGLLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 395 VLSIFLLPLMHTYASLAVICALIGFSSGYFslMPVVT---EDLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITqK 471
Cdd:cd17325 72 AVSTLLFAFATSYWQLLLARFLQGLASAAV--WPAAMaliADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-G 148
|
170 180
....*....|....*....|.
gi 41281606 472 YDFSFYICGLLYMVGILFLLI 492
Cdd:cd17325 149 YRAPFLVCAALALLALVLALL 169
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
42-491 |
3.99e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 52.24 E-value: 3.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 42 SFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSlSMGITLIVGPFI-GLFINTCGCRQTAIIGGLVNSLgWVLSA 120
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLS-ALNLGVAVSMLPaGWLLDRFGERRVLAVGLLLMGA-AALLM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 121 YAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKR-RALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMFIQGA 199
Cdd:cd17475 79 ALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPReRGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 200 LSLNLCVCGALMRplspeklencPEAEEPCALPAYSTESVKSGGPLGmaeeqdRRPgneemvcdlqtqecqgqthPRKNV 279
Cdd:cd17475 159 VSILAAVLFWLFY----------REPPAASAATESASTLLRSLKEVL------RNR-------------------DVWLI 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 280 CAFRVLKTVSQLTVQVrrgfrdwhsgyfgtaslftnrmfvafiFWALfayssFVIPFIHLPEIVSLYnlseqndtfpLTS 359
Cdd:cd17475 204 AIAGALLVAPQFALLT---------------------------FLLL-----FLHDHLGLSVVAAGA----------LLA 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 360 IIAILHIFGKVILGAVAD------LPCISVWNVFLIANFTLVLSifLLPLMHTYASLAVICALIGFS-SGYFSLMPVVTE 432
Cdd:cd17475 242 VAQLGGALGRIGLGRVSDrvfggrRRPVLVITAAIAAAALLVLS--LLSPGTPLWLLVLLLILLGLFaIGWNGLYLTLVA 319
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 41281606 433 DLVGTEHLANAYGIIICANGISALLGPPFAGWIFDITQKYDFSFYICGLLYMVGILFLL 491
Cdd:cd17475 320 ESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
325-492 |
1.33e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 50.50 E-value: 1.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 325 ALFAYSSFVIPFIHLPEIVSLYNLSEQNDTFpLTSIIAILHIFGKVILGAVADlpCISVWNVFLIANFTLVLSIFLLPLM 404
Cdd:cd06174 5 FFLTGLARGLISPLLPALLQSFGLSASQLGL-LFALFSLGYALLQPLAGLLAD--RFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 405 HTYASLAVICALIGFSSG-YFSLMPVVTEDLVGTEHLANAYGIIICANGISALLGPPFAGWIFDItqkYDFSFYICGLLY 483
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGlIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASS---LGFGWRAVFLIA 158
|
....*....
gi 41281606 484 MVGILFLLI 492
Cdd:cd06174 159 AALALLAAI 167
|
|
| MFS_Mch1p_like |
cd17354 |
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
348-457 |
2.50e-06 |
|
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 49.56 E-value: 2.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 348 LSEQNDTFPLTSIIAILHIFGKVILGAVADLPCIS------VWNVFLIANFTLVLSIFLLPLMHTYasLAVICALIGFSS 421
Cdd:cd17354 226 LTGPSNTSTLVSLFSIFSFLGRLLSGLLSDLFVRKfrlprpSRMVLLLLILSLGHLLQAFGLPSGA--LYVASALIGFGY 303
|
90 100 110
....*....|....*....|....*....|....*..
gi 41281606 422 GY-FSLMPVVTEDLVGTEHLANAYGIIICANGISALL 457
Cdd:cd17354 304 GGlFSIAPTIVSELFGLKNFGTNYGFLMLAPAIGSLI 340
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
40-227 |
4.78e-06 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 49.16 E-value: 4.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 40 LSSFFVHILIMGSQMALGVLNVEWLEEFHQSrGLTAWVSS-LSMGITlIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVL 118
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPS-SNSTWISTaWSLAQA-VLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 119 SAYAANVQSL---FITFGVAAGLGSGMAYLPAVVMVGRYfqkrRALAQG----LSTTGTGFGTFLMTVLLKYLCAeyGWR 191
Cdd:cd06179 79 AGTAKSVNMLiggQALIGIGAGTQGLGAAVASELVPNKY----RGLVQGvvnlVASPGSALGPLIAGALVEANAA--GWR 152
|
170 180 190
....*....|....*....|....*....|....*..
gi 41281606 192 NAMFIQGALS-LNLCVCGALMRPLSPEKLENCPEAEE 227
Cdd:cd06179 153 WIFYINAIFNaLALILLFFFYHPPPRPQLHGSSTRQK 189
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
12-202 |
1.63e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.19 E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 12 LEDDRKAKNKKTLKPHPDIDGGWAWMMVLSSFFVHILIMGSQMALG----VLNVEWLEEFHQSRGLTAWVSSLSMGITLI 87
Cdd:cd17325 171 LPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGalepFLPLYAAELGGLSPAQIGLLFGAQGLASAL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 88 VGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVQSLFITFgVAAGLGSGMAYLPAVVMVGRYF-QKRRALAQGLS 166
Cdd:cd17325 251 SQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLL-ALLGLGLGLVFPATLALLADIVpPEGRGTAMGLF 329
|
170 180 190
....*....|....*....|....*....|....*.
gi 41281606 167 TTGTGFGTFLMTVLLKYLCAEYGWRNAMFIQGALSL 202
Cdd:cd17325 330 NTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLL 365
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
36-202 |
1.86e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.88 E-value: 1.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 36 WMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLsMGITLIVGPFI-GLFINTCGCRQTAIIGGLVNSL 114
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSA-FLIAYAVGKFIsGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 115 GWVLSAYAANVqSLFITFGVAAGLGSGMAYLPAVVMVGRYF-QKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNA 193
Cdd:cd17312 81 ANIFMGFSTSL-WFFAVLWGLNGLFQSMGWPPCVKLLGNWFsKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAA 159
|
....*....
gi 41281606 194 MFIQGALSL 202
Cdd:cd17312 160 FLVPGIVGL 168
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
72-212 |
5.27e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 45.65 E-value: 5.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 72 GLTAWVSSLSMG----ITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVQSLFITFGVAAGLGSGMAYLPA 147
Cdd:cd17504 213 GLGITEAGLLLLpgalVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASL 292
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41281606 148 VVMVGRYFQKRR-----ALAQGLSTTGTGFGTFLMTVLLK---------YLCAEYGWRNAMFIQGALSLNLCVCGALMR 212
Cdd:cd17504 293 PNIVVESVPPDRtgiatGMNTVLRTIGSAIGPAIAGAILTtytvsitsgGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
74-217 |
6.37e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 45.37 E-value: 6.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 74 TAWVSSLSMgITLIVGPFIGLFINTC----GCRQTAIIGGLVNSLGWVLSAYAANVQSLFITFGVAaGLGSGMAYLPAVV 149
Cdd:cd17371 33 EAEAGLLGT-VTLAGGAIGGILGGILadrfGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALA-GLGFGGEWAAGAA 110
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41281606 150 MVG-----RYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRnAMFIQGALSLNLCVcgaLMRPLSPE 217
Cdd:cd17371 111 LMAeyvpaRHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWR-VLFLLGALPALLVL---FIRRFVKE 179
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
76-202 |
9.84e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 44.65 E-value: 9.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 76 WVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVQSLFItFGVAAGLGSGMAYLPAVVMVGRYF 155
Cdd:TIGR00895 56 FLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLI-LRFLAGLGLGGLMPNLNALVSEYA 134
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 41281606 156 -QKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMFIQGALSL 202
Cdd:TIGR00895 135 pKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPL 182
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
34-202 |
1.31e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 44.16 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 34 WAWMMVLSSFFVhilimgsQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNS 113
Cdd:cd17341 3 LSWLSFFLGFMV-------WFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 114 LGWVLSAYAANVQSLFITFGVAAGLGSGMaYLPAVVMVGRYFQKRR-----ALAQGLSTTGTGFGTFLMTVL---LKYLC 185
Cdd:cd17341 76 IPLLALALAVSSYWGLLVLGFLLGFAGAN-FASGQPWASFWFPKEKiggaaGGIAGAGNMGVAVSQLLAPLIagaIVFDG 154
|
170
....*....|....*..
gi 41281606 186 AEYGWRNAMFIQGALSL 202
Cdd:cd17341 155 GFVGWRNAFFVPGILLA 171
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
316-491 |
1.36e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.13 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 316 RMFVAFIFWALFAYSSFVIPFIhLPEI-VSLYNLSEQNDTFpLTSIIAILHIFGKVILGAVADlpcisVWNVFLIANFTL 394
Cdd:cd17316 178 RTLLLILLWFFISFGYYGLTTF-LPTYlQTVLGLSPATSSL-YLLLISLGALVGALIAGLLSD-----RIGRKKTLVIGL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 395 VLSI------FLLPLMHTYASLAVICALIGFSSGYFSLMPVVTEDLVGTEHLANAYGIIICANGISALLGPPFAGWIFDI 468
Cdd:cd17316 251 ILSGilalplFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS 330
|
170 180
....*....|....*....|...
gi 41281606 469 TQKYDFSFYICGLLYMVGILFLL 491
Cdd:cd17316 331 TGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
316-491 |
2.24e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.30 E-value: 2.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 316 RMFVAFIFWALFAYSSFVIPFIHL-------PEIVSLYNLseqndtFPLTSIIAILhifgkvILGAVADLpcISVWNVFL 388
Cdd:cd17370 203 WLYLLAVALFALGNFSFAFLILRAqelglsaALIPLLYAL------FNLVYALAAY------PAGRLSDR--IGRKKLLI 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 389 IANFTLVLSIFLLPLMHTYASLAVICALIGFSSGYF-SLMPVVTEDLVGTEHLANAYGIIICANGISALLGPPFAGWIFD 467
Cdd:cd17370 269 LGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWD 348
|
170 180
....*....|....*....|....
gi 41281606 468 ITQkYDFSFYICGLLYMVGILFLL 491
Cdd:cd17370 349 LIS-PSAAFLFSAVLALIALLLLL 371
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
35-202 |
2.51e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 43.30 E-value: 2.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 35 AWMMVLSSFFVHILIMGSqmaLGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 114
Cdd:COG0738 9 ALIAIYLLFFLWGFATAL---WGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 115 GWVLSAYAANVqSLFITFGVAAGLGSGM---AYLPAVVMVGRYFQKRR-ALAQGLSTTGTGFGTFLMTVLLKyLCAEYGW 190
Cdd:COG0738 86 GLLLFALAPSY-PLLLLALFLLGLGLGLldvAANPYVAALGPETAASRlNLLHAFFSLGALLGPLLGGLLIL-LGLSLSW 163
|
170
....*....|..
gi 41281606 191 RNAMFIQGALSL 202
Cdd:COG0738 164 HLPYLILAVLLL 175
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
36-218 |
2.79e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 43.33 E-value: 2.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 36 WMMvlssFFVHILIMGSQMAL-GVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 114
Cdd:COG2223 208 WLL----SLLYFGTFGSFIGFsSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMAL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 115 GWVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYF-QKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYG-WRN 192
Cdd:COG2223 284 GLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFpTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTA 363
|
170 180
....*....|....*....|....*.
gi 41281606 193 AMFIQGALSLnLCVCGALMRPLSPEK 218
Cdd:COG2223 364 AFLVFAVLAL-VALVLTLLLYRRPRR 388
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
370-491 |
4.28e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.60 E-value: 4.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 370 VILGAVADlpCISVWNVFLIANFTLVLSIFLLPLMHTYAS-----LAVICALIGFSSGYF-----SLMPvvteDLVGTEH 439
Cdd:cd06173 52 PFAGVLAD--RFDRRRLLILADLLRALLAAVLALLALLGSlslwlLLVLAFLLGIASAFFgparqALLP----ELVPKEQ 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 41281606 440 LANAYGIIICANGISALLGPPFAGWIFDITQkYDFSFYICGLLYMVGILFLL 491
Cdd:cd06173 126 LVRANALNSLATQLARIIGPALGGLLVALLG-PGGAFAINALSFLLSALLLL 176
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
69-202 |
4.72e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.58 E-value: 4.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 69 QSRGLTAW--VSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVQSLFItFGVAAGLGSGMAYlP 146
Cdd:cd17489 222 AERGISNAglFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLL-AAVLYGLGFGLLF-P 299
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 41281606 147 A--VVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMFIQGALSL 202
Cdd:cd17489 300 AlqALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVL 357
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
65-491 |
4.74e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.54 E-value: 4.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 65 EEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVqSLFITFGVAAGLGSGMAY 144
Cdd:cd17478 24 AKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNY-WLLLLLVALAGIGSAAFH 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 145 LPAVVMVGRYFQKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGwRNAMFIQGALSlnLCVCGALMRPLSPEKLENCPE 224
Cdd:cd17478 103 PEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFG-GLGLLILLIIP--GLAVALLLLRLRPLKKPEAKK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 225 AEEPCALPAYSTesvksggplgmaeeqdrrpgneemvcdlqtqecqgqthprknvcafRVLKTVSQLTVqvrrgfrdwhs 304
Cdd:cd17478 180 AAAKSSARSTLK----------------------------------------------GVWRALLLLLI----------- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 305 gyfgtaslftnrmFVAFIFWALFAYSSFvipfihLPEIVSLYNLSEQNDTFPLtSIIAILHIFGKVILGAVADLpcISVW 384
Cdd:cd17478 203 -------------IVFLRSWVLSSLTTF------LPFYLVQRGYSLVFAGLLL-SLFLFAGAIGTLIGGPLSDR--FGRR 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 385 NVFLIANFTLVLSIFLLPLMHTYASLAVIcALIGFS-SGYFSLMPVVTEDLVGtEHLANAYGIII-CANGISALLGPPFa 462
Cdd:cd17478 261 RVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLlFASFPVTVVLAQELLP-GNVGLASGLMMgLSFGLGGIGAPVL- 337
|
410 420
....*....|....*....|....*....
gi 41281606 463 GWIFDITqKYDFSFYICGLLYMVGILFLL 491
Cdd:cd17478 338 GALADAF-GLESVLLILALLPLLGALLAF 365
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
35-211 |
6.51e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 42.17 E-value: 6.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 35 AWMMVLSsFFVHILIMGSQMAlgvlnveWLEEFHQSRGLTA----WVSSLSMGITLIVGPFIGLFINTCGCRQ-TAIIGG 109
Cdd:COG2807 217 AWLLTLF-FGLQSLLYYAVVA-------WLPPILRDAGLSAatagLLLSLFQLAGIPGSLLVPLLADRLGDRRpLLLLLG 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 110 LVNSLGWVLSAYAAnvQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRR------ALAQGLSTTGTGFGTFLMTVLLKY 183
Cdd:COG2807 289 LLGLAGLLGLLLAP--GSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAeaaalsGMAQSVGYLLAALGPLLVGALHDA 366
|
170 180
....*....|....*....|....*...
gi 41281606 184 LcaeYGWRNAMFIQGALSLNLCVCGALM 211
Cdd:COG2807 367 T---GSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
310-469 |
7.23e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.20 E-value: 7.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 310 ASLFTNRMFVAFIFWALFAYSSFVIPFIHLPEIVSLYNLSEQNDTFPLTSIIAILHIFGKVILGAVADLpcISVWNVFLI 389
Cdd:COG2211 222 KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR--FGKKKAFII 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 390 ANFTLVLSIFLLPLM--HTYASLAVICALIGFSSGYFSLMP------VVTEDLVGTEHLANA--YGIIICANGISALLGP 459
Cdd:COG2211 300 GLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPwamladVVDYDEWKTGRRREGlyFGIFTFAIKLGQALAG 379
|
170
....*....|
gi 41281606 460 PFAGWIFDIT 469
Cdd:COG2211 380 ALAGLLLALF 389
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
35-183 |
1.04e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.43 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 35 AWMMVLSSFFVHILIMGSQMALGVLNVEWLeeFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSL 114
Cdd:COG2211 229 PFLLLLLAYLLFFLALALVAALLLYYFKYV--LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 115 GWVLSAYAANVQ-SLFITFGVAAGLGSGMAYLPAVVMVG--------RYFQKRRALAQGLST----TGTGFGTFLMTVLL 181
Cdd:COG2211 307 GLLLLFFLGPGNlWLLLVLAALAGIGLGAILVLPWAMLAdvvdydewKTGRRREGLYFGIFTfaikLGQALAGALAGLLL 386
|
..
gi 41281606 182 KY 183
Cdd:COG2211 387 AL 388
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
105-233 |
2.14e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 40.37 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 105 AIIGGLVNSLGWVLSAYAANVQSLFITFGVAAGLGSGMAYLPAVVMVGRYFQK-RRALAQGLSTTGTGFGTFLMTVLLKY 183
Cdd:cd06180 66 LIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAaGRGHLIGLLFAGVGLGIALSGLLVPA 145
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 41281606 184 LCAE-YGWRNAMFIQGALSLnlcVCGALMRPLSPEKLENCPEAEEPCALPA 233
Cdd:cd06180 146 GLGGgLSWRAGWLALALLSA---VLLLLSFLLLRRGPSAPTEASAAESAPG 193
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
339-465 |
2.45e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 40.23 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 339 LPEIVSLYNLSEQNDTFpLTSIIAILHIFGKVILGAVADLpcISVWNVFLIANFTLVLSIFLLPLMHTYASLAVICALIG 418
Cdd:cd17324 22 LPDIARDFGVSVAQAGL-LVSAYALGYALGALLLGPLSDR--IERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAG 98
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 41281606 419 FS-SGYFSLMPVVTEDLVGTEHLANAYGIIICANGISALLGPPFAGWI 465
Cdd:cd17324 99 LAhGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL 146
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
65-202 |
3.74e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.46 E-value: 3.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 65 EEFHQSRGLTAWVSS---LSMGITLIVGPFIG-LFintcGCRQTAIIGGLVNSLGWVLSAYAANVQSLfITFGVAAGLGS 140
Cdd:cd17321 24 RDLGASPSQLQWVVNaylLAFAALLLLAGRLGdRF----GRKRVFLIGLALFGLASLLCALAPSLAFL-IAARALQGIGA 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41281606 141 GMAYLPAVVMVGRYFQ-KRRALAQGLSTT----GTGFGTFLMTVLLKYLcaeyGWRNAMFIQGALSL 202
Cdd:cd17321 99 AAIMPASLALIAATFPgERRGRALGLWGAvvgiGAALGPLLGGLLLELF----GWRWIFLINVPIGL 161
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
64-202 |
4.62e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 39.11 E-value: 4.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 64 LEEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVQSLFItFGVAAGLGSGMA 143
Cdd:cd17365 26 AQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGLGAA 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 144 YLPAVVMVGRYF-QKRRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMFIQGALSL 202
Cdd:cd17365 105 MPNAITLVSEYApARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPL 164
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
330-493 |
4.69e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.13 E-value: 4.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 330 SSFVIPFIhlpeivSLYNLSEQNDTFPLTSIIAILHIFGKVIL----GAVADLpcISVWNVFLIANFTLVLSIFLLPLMH 405
Cdd:cd17329 15 FFMVWPFM------AIYLHQQLGLSASIVGLVLALSAVAGIVAsligGRLADR--FGRKPVMLAGLLLRALGFALLGFAH 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 406 TYASLAVICALIGFSSG-YFSLMPVVTEDLVGTEHLANAYGIIICANGISALLGPPFAGWIFDitqkYDFS--FYICGLL 482
Cdd:cd17329 87 SPWLFAIALVLTGFGGGlFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL----YSFRllFLAAAVL 162
|
170
....*....|.
gi 41281606 483 YMVGILFLLIQ 493
Cdd:cd17329 163 FLLAALVLLFL 173
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
65-202 |
4.81e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.45 E-value: 4.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 65 EEFHQSRGLTAWVSSLSMGITLIVGPFIGLFINTCGCRQTAIIGGLVNSLGWVLSAYAANVQSLFITFGVAAGLGSGMAY 144
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWA 106
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 41281606 145 LpAVVMVGRYFQK-RRALAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMFIQGALSL 202
Cdd:cd17324 107 I-AAAYAADLVPPeKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL 164
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
386-492 |
5.25e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.11 E-value: 5.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 386 VFLIANFTLVLSIFLLPLMHTYASLAVICALIGFSSGYF--SLMPVVTeDLVGTEHLANAYGIIICANGISALLGPPFAG 463
Cdd:cd17489 63 LLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFttAAATLVA-DIIPPSRRGEGIGYYGLATTLAMALGPALGL 141
|
90 100
....*....|....*....|....*....
gi 41281606 464 WIFDiTQKYDFSFYICGLLYMVGILFLLI 492
Cdd:cd17489 142 FLYQ-HLGFAVLFIVAAVLALLALLLVFL 169
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
47-181 |
6.33e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.08 E-value: 6.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281606 47 ILIMGSQMALGVLNVEWLEEFHqsrGLTAWVSSLSM----GITLIVGPFIGLFINTCGCRQTAIIGGLVNSLG-WVLSAY 121
Cdd:cd17321 178 FLLGAALGGLLFLLPLYLQGVL---GYSPLQAGLALlplaLAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGlLLLALL 254
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41281606 122 AANVQSLFITFG-VAAGLGSGMAYLPA-VVMVGRYFQKRRALAQGLSTT----GTGFGTFLMTVLL 181
Cdd:cd17321 255 GADSSVWLLLPGlVLLGLGLGLFATPLtNAALSSVPKEKAGAASGILNTarqlGGALGVALLGALL 320
|
|
| |
