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Conserved domains on  [gi|61651675|ref|NP_080994|]
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ankyrin repeat domain-containing protein 13A isoform 1 [Mus musculus]

Protein Classification

GPCR_chapero_1 domain-containing protein( domain architecture ID 12790908)

GPCR_chapero_1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GPCR_chapero_1 pfam11904
GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together ...
 156-468 1.44e-127

GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.


:

Pssm-ID: 463391  Cd Length: 298  Bit Score: 376.21  E-value: 1.44e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   156 RVDITLLGFENMSWIRGRRSFIFKG-GDNWAELMEVNHDDRVVTTEHfDLSQEMERLTLDlmkpksrEVERRLTSPVINT 234
Cdd:pfam11904   1 RADTTLLGFDGFKWQRGDQSFLFLGdGDSPGSLLELDHDEKEVQLEG-AGAEASEEEVEE-------EVAARLQTPIVRP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   235 SLDTKNVAFERTKSGfWGwRTDKAEVVNGYEAKVYSVNNVSVITRIRTEHLTEEEKKRYK-------EDRNPLESLLGTV 307
Cdd:pfam11904  73 GIDVTKISFERNKSG-WR-RQEKTEMVGGYKAKVYDASNVELSTKSRTEHLSEEEKAKLKsaleppeGSRTPLQSFLGIA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   308 EHQFGAQGDLATE-CATVNNPTAITPDEYFDEdfdlkdrdigrPKELTIRTQKFKATLWMCEEFPLSLvEQVIPIIDLMA 386
Cdd:pfam11904 151 EEEKGWFGKTREEsEAPPTNPTALTPEEYFDP-----------PKEESEKKKGFKATLWLSEDFPLSL-EQLLPILDLLA 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   387 RTSAHFARLRDFIKLDFPPGFPVKIEIPLFHVLNARITFGNVNGCstaDESQGVEGT-PAEAVSEATNFEVDQSVFEIPE 465
Cdd:pfam11904 219 NKVKHFRRLREFITLKLPPGFPVKIEIPVFPTVNARITFTKFEEL---DPVEEFSTPiKSPERGSPSSCEIDDDPFEIPS 295


                  ...
gi 61651675   466 SYH 468
Cdd:pfam11904 296 GYT 298
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-90 1.89e-16

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 80.00  E-value: 1.89e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   4 ARDTSSRFPLHLLVWNNDYEQLeKELRDQNA--EALDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEA 81
Cdd:COG0666 115 ARDKDGETPLHLAAYNGNLEIV-KLLLEAGAdvNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLA 193


                ....*....
gi 61651675  82 VSTGDPEMV 90
Cdd:COG0666 194 AENGHLEIV 202
 
Name Accession Description Interval E-value
GPCR_chapero_1 pfam11904
GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together ...
 156-468 1.44e-127

GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.


Pssm-ID: 463391  Cd Length: 298  Bit Score: 376.21  E-value: 1.44e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   156 RVDITLLGFENMSWIRGRRSFIFKG-GDNWAELMEVNHDDRVVTTEHfDLSQEMERLTLDlmkpksrEVERRLTSPVINT 234
Cdd:pfam11904   1 RADTTLLGFDGFKWQRGDQSFLFLGdGDSPGSLLELDHDEKEVQLEG-AGAEASEEEVEE-------EVAARLQTPIVRP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   235 SLDTKNVAFERTKSGfWGwRTDKAEVVNGYEAKVYSVNNVSVITRIRTEHLTEEEKKRYK-------EDRNPLESLLGTV 307
Cdd:pfam11904  73 GIDVTKISFERNKSG-WR-RQEKTEMVGGYKAKVYDASNVELSTKSRTEHLSEEEKAKLKsaleppeGSRTPLQSFLGIA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   308 EHQFGAQGDLATE-CATVNNPTAITPDEYFDEdfdlkdrdigrPKELTIRTQKFKATLWMCEEFPLSLvEQVIPIIDLMA 386
Cdd:pfam11904 151 EEEKGWFGKTREEsEAPPTNPTALTPEEYFDP-----------PKEESEKKKGFKATLWLSEDFPLSL-EQLLPILDLLA 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   387 RTSAHFARLRDFIKLDFPPGFPVKIEIPLFHVLNARITFGNVNGCstaDESQGVEGT-PAEAVSEATNFEVDQSVFEIPE 465
Cdd:pfam11904 219 NKVKHFRRLREFITLKLPPGFPVKIEIPVFPTVNARITFTKFEEL---DPVEEFSTPiKSPERGSPSSCEIDDDPFEIPS 295


                  ...
gi 61651675   466 SYH 468
Cdd:pfam11904 296 GYT 298
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-90 1.89e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 80.00  E-value: 1.89e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   4 ARDTSSRFPLHLLVWNNDYEQLeKELRDQNA--EALDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEA 81
Cdd:COG0666 115 ARDKDGETPLHLAAYNGNLEIV-KLLLEAGAdvNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLA 193


                ....*....
gi 61651675  82 VSTGDPEMV 90
Cdd:COG0666 194 AENGHLEIV 202
Ank_2 pfam12796
Ankyrin repeats (3 copies);
13-96 3.37e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.44  E-value: 3.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675    13 LHLLVWNNDYEQLeKELRDQNAEA--LDPRGRTLLHLAVSLGHLESARVLLRHKAdvTKENGQGWTVLHEAVSTGDPEMV 90
Cdd:pfam12796   1 LHLAAKNGNLELV-KLLLENGADAnlQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIV 77


                  ....*.
gi 61651675    91 YTVLQH 96
Cdd:pfam12796  78 KLLLEK 83
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 10-97 3.06e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.99  E-value: 3.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   10 RFPLHLLVWNNDYEQLEkELRDQNAEALD---PRGRTLLHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEAVSTGD 86
Cdd:PHA02875  69 ESELHDAVEEGDVKAVE-ELLDLGKFADDvfyKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGD 147

                         90
                 ....*....|.
gi 61651675   87 PEMVYTVLQHR 97
Cdd:PHA02875 148 IKGIELLIDHK 158
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 40-69 7.58e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 7.58e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 61651675     40 RGRTLLHLAVSLGHLESARVLLRHKADVTK 69
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
GPCR_chapero_1 pfam11904
GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together ...
 156-468 1.44e-127

GPCR-chaperone; This domain, and the associated ANK family repeat pfam00023 domain, together act as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2.


Pssm-ID: 463391  Cd Length: 298  Bit Score: 376.21  E-value: 1.44e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   156 RVDITLLGFENMSWIRGRRSFIFKG-GDNWAELMEVNHDDRVVTTEHfDLSQEMERLTLDlmkpksrEVERRLTSPVINT 234
Cdd:pfam11904   1 RADTTLLGFDGFKWQRGDQSFLFLGdGDSPGSLLELDHDEKEVQLEG-AGAEASEEEVEE-------EVAARLQTPIVRP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   235 SLDTKNVAFERTKSGfWGwRTDKAEVVNGYEAKVYSVNNVSVITRIRTEHLTEEEKKRYK-------EDRNPLESLLGTV 307
Cdd:pfam11904  73 GIDVTKISFERNKSG-WR-RQEKTEMVGGYKAKVYDASNVELSTKSRTEHLSEEEKAKLKsaleppeGSRTPLQSFLGIA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   308 EHQFGAQGDLATE-CATVNNPTAITPDEYFDEdfdlkdrdigrPKELTIRTQKFKATLWMCEEFPLSLvEQVIPIIDLMA 386
Cdd:pfam11904 151 EEEKGWFGKTREEsEAPPTNPTALTPEEYFDP-----------PKEESEKKKGFKATLWLSEDFPLSL-EQLLPILDLLA 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   387 RTSAHFARLRDFIKLDFPPGFPVKIEIPLFHVLNARITFGNVNGCstaDESQGVEGT-PAEAVSEATNFEVDQSVFEIPE 465
Cdd:pfam11904 219 NKVKHFRRLREFITLKLPPGFPVKIEIPVFPTVNARITFTKFEEL---DPVEEFSTPiKSPERGSPSSCEIDDDPFEIPS 295


                  ...
gi 61651675   466 SYH 468
Cdd:pfam11904 296 GYT 298
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-90 1.89e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 80.00  E-value: 1.89e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   4 ARDTSSRFPLHLLVWNNDYEQLeKELRDQNA--EALDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEA 81
Cdd:COG0666 115 ARDKDGETPLHLAAYNGNLEIV-KLLLEAGAdvNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLA 193


                ....*....
gi 61651675  82 VSTGDPEMV 90
Cdd:COG0666 194 AENGHLEIV 202
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-96 1.86e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 77.30  E-value: 1.86e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   4 ARDTSSRFPLHLLVWNNDYEQLeKELRDQNA--EALDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEA 81
Cdd:COG0666  82 AKDDGGNTLLHAAARNGDLEIV-KLLLEAGAdvNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                        90
                ....*....|....*
gi 61651675  82 VSTGDPEMVYTVLQH 96
Cdd:COG0666 161 AANGNLEIVKLLLEA 175
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-127 2.82e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 73.83  E-value: 2.82e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   4 ARDTSSRFPLHLLVWNNDYEQLeKELRDQNA--EALDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEA 81
Cdd:COG0666 148 AQDNDGNTPLHLAAANGNLEIV-KLLLEAGAdvNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLA 226

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 61651675  82 VSTGDPEMVYTVLQHRDYHNTSMALEGVPELLHKILEAPDFYVQMK 127
Cdd:COG0666 227 AENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLL 272
Ank_2 pfam12796
Ankyrin repeats (3 copies);
13-96 3.37e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.44  E-value: 3.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675    13 LHLLVWNNDYEQLeKELRDQNAEA--LDPRGRTLLHLAVSLGHLESARVLLRHKAdvTKENGQGWTVLHEAVSTGDPEMV 90
Cdd:pfam12796   1 LHLAAKNGNLELV-KLLLENGADAnlQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIV 77


                  ....*.
gi 61651675    91 YTVLQH 96
Cdd:pfam12796  78 KLLLEK 83
Ank_4 pfam13637
Ankyrin repeats (many copies);
41-90 1.28e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 56.90  E-value: 1.28e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 61651675    41 GRTLLHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEAVSTGDPEMV 90
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVL 50
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
12-96 4.05e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.12  E-value: 4.05e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675  12 PLHLLVWNNDYEQLEKELRDQNA--EALDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEAVSTGDPEM 89
Cdd:COG0666  56 LLLLAAALAGDLLVALLLLAAGAdiNAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEI 135


                ....*..
gi 61651675  90 VYTVLQH 96
Cdd:COG0666 136 VKLLLEA 142
Ank_2 pfam12796
Ankyrin repeats (3 copies);
45-115 1.70e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.04  E-value: 1.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675    45 LHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEAVSTGDPEMVYTVLQH-----RDYHNTSM-------ALEGVPEL 112
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHadvnlKDNGRTALhyaarsgHLEIVKLL 80


                  ...
gi 61651675   113 LHK 115
Cdd:pfam12796  81 LEK 83
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 10-97 3.06e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.99  E-value: 3.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   10 RFPLHLLVWNNDYEQLEkELRDQNAEALD---PRGRTLLHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEAVSTGD 86
Cdd:PHA02875  69 ESELHDAVEEGDVKAVE-ELLDLGKFADDvfyKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGD 147

                         90
                 ....*....|.
gi 61651675   87 PEMVYTVLQHR 97
Cdd:PHA02875 148 IKGIELLIDHK 158
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 38-122 3.18e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 50.28  E-value: 3.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675   38 DPRGRTLLHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMA------LEGVPE 111
Cdd:PTZ00322 112 DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGAnakpdsFTGKPP 191

                         90
                 ....*....|....
gi 61651675  112 LLHK---ILEAPDF 122
Cdd:PTZ00322 192 SLEDspiSSHHPDF 205
Ank_5 pfam13857
Ankyrin repeats (many copies);
28-81 1.91e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.33  E-value: 1.91e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 61651675    28 ELRDQNAEALDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEA 81
Cdd:pfam13857   3 EHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 25-96 2.79e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.17  E-value: 2.79e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 61651675   25 LEKELR-DQNAEALDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEAVSTGDPEmVYTVLQH 96
Cdd:PLN03192 541 LEELLKaKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHK-IFRILYH 612
Ank_2 pfam12796
Ankyrin repeats (3 copies);
5-71 4.18e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.41  E-value: 4.18e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61651675     5 RDTSSRFPLHLLVWNNDYEQLeKELRDQNAEALDPRGRTLLHLAVSLGHLESARVLLRHKADVTKEN 71
Cdd:pfam12796  26 QDKNGRTALHLAAKNGHLEIV-KLLLEHADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 40-71 1.88e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 1.88e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 61651675    40 RGRTLLHLAV-SLGHLESARVLLRHKADVTKEN 71
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 40-67 3.02e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.39  E-value: 3.02e-04
                          10        20
                  ....*....|....*....|....*...
gi 61651675    40 RGRTLLHLAVSLGHLESARVLLRHKADV 67
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADI 28
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 40-69 7.58e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 7.58e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 61651675     40 RGRTLLHLAVSLGHLESARVLLRHKADVTK 69
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-96 2.37e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 40.32  E-value: 2.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61651675  13 LHLLVWNNDYEQLEKELRDQNAEALDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEAVSTGDPEMVYT 92
Cdd:COG0666  26 LAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKL 105


                ....
gi 61651675  93 VLQH 96
Cdd:COG0666 106 LLEA 109
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 43-94 4.30e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.97  E-value: 4.30e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 61651675   43 TLLHLAVSLGHLESARVLLRHKADVTKENGQGWTVLHEAVSTGDPEMVYTVL 94
Cdd:PHA02875 137 SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLL 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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