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Conserved domains on  [gi|23956176|ref|NP_080750|]
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protein SGT1 homolog [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 1002571)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03088 super family cl33632
SGT1, suppressor of G2 allele of SKP1; Provisional
 21-336 5.41e-82

SGT1, suppressor of G2 allele of SKP1; Provisional


The actual alignment was detected with superfamily member PLN03088:

Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 252.79  E-value: 5.41e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176   21 ALIDGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALE 100
Cdd:PLN03088  12 AFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAKA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  101 TFAEGQKLDSTDTNFDTWIKRCQE----------------IQNGSESEV-----SASQRTQSKIKY--DWYQTESHVIIT 157
Cdd:PLN03088  92 ALEKGASLAPGDSRFTKLIKECDEkiaeeekdlvqpvpsdLPSSVTAPPveeadATPVVPPSKPKYrhEFYQKPEEVVVT 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  158 LMIKSVQKNDVRVGFSERELSALVKIPAGEDYSLKLRLLHPIIPEQSTFKVLSTKIEIKMKKPEAVRWEKLEGQGDEPTP 237
Cdd:PLN03088 172 VFAKGVPAENVNVDFGEQILSVVIEVPGEDAYHLQPRLFGKIIPDKCKYEVLSTKIEIRLAKAEPITWASLEYGKGPAVL 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  238 KQFTADV----KNMYPSSSHYTRNWDKLVGEIKEEEKNEKLEGDAALNKLFQQIYSDGSDEVKRAMNKSFMESGGTVLST 313
Cdd:PLN03088 252 PKPNVSSevsqRPAYPSSKKKKDDWDKLEAEVKKEEKDEKLDGDAALNKFFREIYQNADEDTRRAMMKSFVESNGTVLST 331

                        330       340
                 ....*....|....*....|...
gi 23956176  314 NWSDVGKRKVEINPPDDMEWKQY 336
Cdd:PLN03088 332 NWKEVGSKKIEGSPPDGMELKKW 354
 
Name Accession Description Interval E-value
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 21-336 5.41e-82

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 252.79  E-value: 5.41e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176   21 ALIDGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALE 100
Cdd:PLN03088  12 AFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAKA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  101 TFAEGQKLDSTDTNFDTWIKRCQE----------------IQNGSESEV-----SASQRTQSKIKY--DWYQTESHVIIT 157
Cdd:PLN03088  92 ALEKGASLAPGDSRFTKLIKECDEkiaeeekdlvqpvpsdLPSSVTAPPveeadATPVVPPSKPKYrhEFYQKPEEVVVT 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  158 LMIKSVQKNDVRVGFSERELSALVKIPAGEDYSLKLRLLHPIIPEQSTFKVLSTKIEIKMKKPEAVRWEKLEGQGDEPTP 237
Cdd:PLN03088 172 VFAKGVPAENVNVDFGEQILSVVIEVPGEDAYHLQPRLFGKIIPDKCKYEVLSTKIEIRLAKAEPITWASLEYGKGPAVL 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  238 KQFTADV----KNMYPSSSHYTRNWDKLVGEIKEEEKNEKLEGDAALNKLFQQIYSDGSDEVKRAMNKSFMESGGTVLST 313
Cdd:PLN03088 252 PKPNVSSevsqRPAYPSSKKKKDDWDKLEAEVKKEEKDEKLDGDAALNKFFREIYQNADEDTRRAMMKSFVESNGTVLST 331

                        330       340
                 ....*....|....*....|...
gi 23956176  314 NWSDVGKRKVEINPPDDMEWKQY 336
Cdd:PLN03088 332 NWKEVGSKKIEGSPPDGMELKKW 354
p23_CS_hSgt1_like cd06489
p23_like domain similar to the C-terminal CS (CHORD-SGT1) domain of human (h) Sgt1 and related ...
 146-229 6.75e-46

p23_like domain similar to the C-terminal CS (CHORD-SGT1) domain of human (h) Sgt1 and related proteins. hSgt1 is a co-chaperone which has been shown to be elevated in HEp-2 cells as a result of stress conditions such as heat shock. It interacts with the heat shock proteins (HSPs) Hsp70 and Hsp90, and it expression pattern is synchronized with these two Hsps. The interaction with HSP90 has been shown to involve the hSgt1_CS domain, and appears to be required for correct kinetochore assembly and efficient cell division. Some proteins in this subgroup contain a tetratricopeptide repeat (TPR) HSP-binding domain N-terminal to this CS domain, and most proteins in this subgroup contain a Sgt1-specific (SGS) domain C-terminal to the CS domain. The SGS domain interacts with some S100 family proteins. Studies suggest that S100A6 modulates in a Ca2+ dependent manner the interactions of hSgt1 with Hsp90 and Hsp70. The yeast Sgt1 CS domain is not found in this subgroup.


Pssm-ID: 107239  Cd Length: 84  Bit Score: 150.99  E-value: 6.75e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176 146 DWYQTESHVIITLMIKSVQKNDVRVGFSERELSALVKIPAGEDYSLKLRLLHPIIPEQSTFKVLSTKIEIKMKKPEAVRW 225
Cdd:cd06489   1 DWYQTESQVVITILIKNVKPEDVSVEFEKRELSATVKLPSGNDYSLKLHLLHPIVPEQSSYKILSTKIEIKLKKTEAIRW 80


                ....
gi 23956176 226 EKLE 229
Cdd:cd06489  81 SKLE 84
SGS pfam05002
SGS domain; This domain was thought to be unique to the SGT1-like proteins, but is also found ...
 256-336 1.91e-40

SGS domain; This domain was thought to be unique to the SGT1-like proteins, but is also found in calcyclin binding proteins.


Pssm-ID: 461514 [Multi-domain]  Cd Length: 81  Bit Score: 136.54  E-value: 1.91e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176   256 RNWDKLVGEIKEEEKNEKLEGDAALNKLFQQIYSDGSDEVKRAMNKSFMESGGTVLSTNWSDVGKRKVEINPPDDMEWKQ 335
Cdd:pfam05002   1 KDWDKLEKEDEKEEKEEKDGGDAALNAFFQKIYADADEDTRRAMMKSFVESNGTVLSTNWDEVGKKKVETKPPDGMEAKK 80


                  .
gi 23956176   336 Y 336
Cdd:pfam05002  81 W 81
SGT1 COG5091
Suppressor of G2 allele of skp1 and related proteins [General function prediction only];
9-336 9.08e-35

Suppressor of G2 allele of skp1 and related proteins [General function prediction only];


Pssm-ID: 227422 [Multi-domain]  Cd Length: 368  Bit Score: 130.21  E-value: 9.08e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176   9 ASSQRLFQSFSDALIDGDPQAALEELTKAL---EQNPDDAQY-YCQ--RAYCHILLGKYRDGIADVKKSLELnpnnctal 82
Cdd:COG5091  37 ACLEKLYFGFSDWHSDATMENAKELLDKALmtaEGRGDRSKIgLVNfrYFVHFFNIKDYELAQSYFKKAKNL-------- 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  83 LRKGICEYHEKDYASALETFAEGQKLDSTDTNfdtwIKRCQEIQNGSESEVSAS------------QRTQSKIKYDWYQT 150
Cdd:COG5091 109 YVDDTLPLWEDRLETKLNKKNKKQKDSTNKHT----IKPVESIENRGDNNSSHSpisplkietapqESPKMEIAYDFSET 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176 151 ESHVIITLMIKSVQKNDVRVGFSERELSALVKIPAGEDYSLKL-RLLHPIIPEQSTFKVLSTKIEIKMKKPEAVRWEKLE 229
Cdd:COG5091 185 SDTAIIFIYRPPVGDEQVSPVLEGNTLSISYQPRRLRLWNDITiSLYKEVYPDIRSIKSFSKRVEVHLRKVEMVRWGGLN 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176 230 GQGDEPTPKQFTADVKN--MYPSSSHYTRNWDKLvgeikEEEKNEKLEGDAALNKLFQQIYSDGSDEVKRAMNKSFMESG 307
Cdd:COG5091 265 GRPADESSRLSDEGKNSdsATPKSSKKQDDWKEL-----MVEDSGDEENPSVMDSLFQKLYQRADDDTRRAMMKSFYESN 339

                       330       340
                ....*....|....*....|....*....
gi 23956176 308 GTVLSTNWSDVGKRKVEINPPDDMEWKQY 336
Cdd:COG5091 340 GTALSTDWDDVKSKTITTEPPEGMEPKHW 368
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 8-107 2.59e-10

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 61.54  E-value: 2.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176     8 PASSQRLFQSFSDALIDGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGI 87
Cdd:TIGR00990 362 PRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFIFSHIQLGV 441

                          90       100
                  ....*....|....*....|
gi 23956176    88 CEYHEKDYASALETFAEGQK 107
Cdd:TIGR00990 442 TQYKEGSIASSMATFRRCKK 461
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 45-78 6.14e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 39.74  E-value: 6.14e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 23956176     45 AQYYCQRAYCHILLGKYRDGIADVKKSLELNPNN 78
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 21-336 5.41e-82

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 252.79  E-value: 5.41e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176   21 ALIDGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALE 100
Cdd:PLN03088  12 AFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMKLEEYQTAKA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  101 TFAEGQKLDSTDTNFDTWIKRCQE----------------IQNGSESEV-----SASQRTQSKIKY--DWYQTESHVIIT 157
Cdd:PLN03088  92 ALEKGASLAPGDSRFTKLIKECDEkiaeeekdlvqpvpsdLPSSVTAPPveeadATPVVPPSKPKYrhEFYQKPEEVVVT 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  158 LMIKSVQKNDVRVGFSERELSALVKIPAGEDYSLKLRLLHPIIPEQSTFKVLSTKIEIKMKKPEAVRWEKLEGQGDEPTP 237
Cdd:PLN03088 172 VFAKGVPAENVNVDFGEQILSVVIEVPGEDAYHLQPRLFGKIIPDKCKYEVLSTKIEIRLAKAEPITWASLEYGKGPAVL 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  238 KQFTADV----KNMYPSSSHYTRNWDKLVGEIKEEEKNEKLEGDAALNKLFQQIYSDGSDEVKRAMNKSFMESGGTVLST 313
Cdd:PLN03088 252 PKPNVSSevsqRPAYPSSKKKKDDWDKLEAEVKKEEKDEKLDGDAALNKFFREIYQNADEDTRRAMMKSFVESNGTVLST 331

                        330       340
                 ....*....|....*....|...
gi 23956176  314 NWSDVGKRKVEINPPDDMEWKQY 336
Cdd:PLN03088 332 NWKEVGSKKIEGSPPDGMELKKW 354
p23_CS_hSgt1_like cd06489
p23_like domain similar to the C-terminal CS (CHORD-SGT1) domain of human (h) Sgt1 and related ...
 146-229 6.75e-46

p23_like domain similar to the C-terminal CS (CHORD-SGT1) domain of human (h) Sgt1 and related proteins. hSgt1 is a co-chaperone which has been shown to be elevated in HEp-2 cells as a result of stress conditions such as heat shock. It interacts with the heat shock proteins (HSPs) Hsp70 and Hsp90, and it expression pattern is synchronized with these two Hsps. The interaction with HSP90 has been shown to involve the hSgt1_CS domain, and appears to be required for correct kinetochore assembly and efficient cell division. Some proteins in this subgroup contain a tetratricopeptide repeat (TPR) HSP-binding domain N-terminal to this CS domain, and most proteins in this subgroup contain a Sgt1-specific (SGS) domain C-terminal to the CS domain. The SGS domain interacts with some S100 family proteins. Studies suggest that S100A6 modulates in a Ca2+ dependent manner the interactions of hSgt1 with Hsp90 and Hsp70. The yeast Sgt1 CS domain is not found in this subgroup.


Pssm-ID: 107239  Cd Length: 84  Bit Score: 150.99  E-value: 6.75e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176 146 DWYQTESHVIITLMIKSVQKNDVRVGFSERELSALVKIPAGEDYSLKLRLLHPIIPEQSTFKVLSTKIEIKMKKPEAVRW 225
Cdd:cd06489   1 DWYQTESQVVITILIKNVKPEDVSVEFEKRELSATVKLPSGNDYSLKLHLLHPIVPEQSSYKILSTKIEIKLKKTEAIRW 80


                ....
gi 23956176 226 EKLE 229
Cdd:cd06489  81 SKLE 84
SGS pfam05002
SGS domain; This domain was thought to be unique to the SGT1-like proteins, but is also found ...
 256-336 1.91e-40

SGS domain; This domain was thought to be unique to the SGT1-like proteins, but is also found in calcyclin binding proteins.


Pssm-ID: 461514 [Multi-domain]  Cd Length: 81  Bit Score: 136.54  E-value: 1.91e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176   256 RNWDKLVGEIKEEEKNEKLEGDAALNKLFQQIYSDGSDEVKRAMNKSFMESGGTVLSTNWSDVGKRKVEINPPDDMEWKQ 335
Cdd:pfam05002   1 KDWDKLEKEDEKEEKEEKDGGDAALNAFFQKIYADADEDTRRAMMKSFVESNGTVLSTNWDEVGKKKVETKPPDGMEAKK 80


                  .
gi 23956176   336 Y 336
Cdd:pfam05002  81 W 81
SGT1 COG5091
Suppressor of G2 allele of skp1 and related proteins [General function prediction only];
9-336 9.08e-35

Suppressor of G2 allele of skp1 and related proteins [General function prediction only];


Pssm-ID: 227422 [Multi-domain]  Cd Length: 368  Bit Score: 130.21  E-value: 9.08e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176   9 ASSQRLFQSFSDALIDGDPQAALEELTKAL---EQNPDDAQY-YCQ--RAYCHILLGKYRDGIADVKKSLELnpnnctal 82
Cdd:COG5091  37 ACLEKLYFGFSDWHSDATMENAKELLDKALmtaEGRGDRSKIgLVNfrYFVHFFNIKDYELAQSYFKKAKNL-------- 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  83 LRKGICEYHEKDYASALETFAEGQKLDSTDTNfdtwIKRCQEIQNGSESEVSAS------------QRTQSKIKYDWYQT 150
Cdd:COG5091 109 YVDDTLPLWEDRLETKLNKKNKKQKDSTNKHT----IKPVESIENRGDNNSSHSpisplkietapqESPKMEIAYDFSET 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176 151 ESHVIITLMIKSVQKNDVRVGFSERELSALVKIPAGEDYSLKL-RLLHPIIPEQSTFKVLSTKIEIKMKKPEAVRWEKLE 229
Cdd:COG5091 185 SDTAIIFIYRPPVGDEQVSPVLEGNTLSISYQPRRLRLWNDITiSLYKEVYPDIRSIKSFSKRVEVHLRKVEMVRWGGLN 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176 230 GQGDEPTPKQFTADVKN--MYPSSSHYTRNWDKLvgeikEEEKNEKLEGDAALNKLFQQIYSDGSDEVKRAMNKSFMESG 307
Cdd:COG5091 265 GRPADESSRLSDEGKNSdsATPKSSKKQDDWKEL-----MVEDSGDEENPSVMDSLFQKLYQRADDDTRRAMMKSFYESN 339

                       330       340
                ....*....|....*....|....*....
gi 23956176 308 GTVLSTNWSDVGKRKVEINPPDDMEWKQY 336
Cdd:COG5091 340 GTALSTDWDDVKSKTITTEPPEGMEPKHW 368
p23_CS_SGT1_like cd06466
p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 ...
 146-229 2.53e-32

p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. ScSgt1 is needed for the G1/S and G2/M cell-cycle transitions, and for assembly of the core kinetochore complex (CBF3) via activation of Ctf13, the F-box protein. Binding of Hsp82 (a yeast Hsp90 homologue) to ScSgt1, promotes the binding of Sgt1 to Skp1 and of Skp1 to Ctf13. Some proteins in this group have an SGT1-specific (SGS) domain at the extreme C-terminus. The ScSgt1-SGS domain binds adenylate cyclase. The hSgt1-SGS domain interacts with some S100 family proteins, and studies suggest that the interaction of hSgt1 with Hsp90 and Hsp70 may be regulated by S100A6 in a Ca2+ dependent fashion. This group also includes the p23_like domains of Melusin and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). Melusin is a vertebrate protein which interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.


Pssm-ID: 107223  Cd Length: 84  Bit Score: 115.76  E-value: 2.53e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176 146 DWYQTESHVIITLMIKSVQKNDVRVGFSERELSALVKIPAGEDYSLKLRLLHPIIPEQSTFKVLSTKIEIKMKKPEAVRW 225
Cdd:cd06466   1 DWYQTDTSVTVTIYAKNVDKEDVKVEFNEQSLSVSIILPGGSEYQLELDLFGPIDPEQSKVSVLPTKVEITLKKAEPGSW 80


                ....
gi 23956176 226 EKLE 229
Cdd:cd06466  81 PSLE 84
p23_like cd06463
Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) ...
 147-229 8.12e-22

Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis. Both p23 and Sba1p can regulate telomerase activity. This group includes domains similar to the C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1). Sgt1 interacts with multiple protein complexes and has the features of a co-chaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. This group also includes the p23_like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). hB-ind1 plays a role in the signaling pathway mediated by the small GTPase Rac1, NUDC is needed for nuclear movement, Melusin interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.


Pssm-ID: 107220  Cd Length: 84  Bit Score: 87.73  E-value: 8.12e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176 147 WYQTESHVIITLMIKSVQKNDVRVGFSERELSALVKIPAGEDYSLKLRLLHPIIPEQSTFKVLSTKIEIKMKKPEA-VRW 225
Cdd:cd06463   1 WYQTLDEVTITIPLKDVTKKDVKVEFTPKSLTVSVKGGGGKEYLLEGELFGPIDPEESKWTVEDRKIEITLKKKEPgEWW 80


                ....
gi 23956176 226 EKLE 229
Cdd:cd06463  81 PRLE 84
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
25-147 1.37e-17

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 80.34  E-value: 1.37e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAE 104
Cdd:COG4785  87 GDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEK 166

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 23956176 105 GQKLDSTDTNFDTWikrcqeiQNGSESEVsASQRTQSKIKYDW 147
Cdd:COG4785 167 ALELDPNDPERALW-------LYLAERKL-DPEKALALLLEDW 201
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
25-112 1.87e-16

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 77.74  E-value: 1.87e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAE 104
Cdd:COG0457  56 GRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYER 135


                ....*...
gi 23956176 105 GQKLDSTD 112
Cdd:COG0457 136 ALELDPDD 143
CS pfam04969
CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans ...
 144-219 9.84e-16

CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2.


Pssm-ID: 461503  Cd Length: 76  Bit Score: 71.13  E-value: 9.84e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23956176   144 KYDWYQTESHVIITLMIKSVQ--KNDVRVGFSERELSalVKIPaGEDYSLKLRLLHPIIPEQSTFKVLSTKIEIKMKK 219
Cdd:pfam04969   2 RYDWYQTLDEVTITIPVKGAGikKKDVKVNIKPRSLK--VKIK-GGYELIDGELFHPIDPEESSWTIEGKKVEITLKK 76
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
25-112 4.32e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 73.89  E-value: 4.32e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAE 104
Cdd:COG0457  22 GRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDK 101


                ....*...
gi 23956176 105 GQKLDSTD 112
Cdd:COG0457 102 ALELDPDD 109
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
25-109 6.38e-15

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 69.43  E-value: 6.38e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIAdVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAE 104
Cdd:COG3063   6 GDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLER 84


                ....*
gi 23956176 105 GQKLD 109
Cdd:COG3063  85 ALELD 89
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
25-104 7.89e-15

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 73.12  E-value: 7.89e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAE 104
Cdd:COG0457  90 GRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEK 169
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 25-114 2.76e-14

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 68.88  E-value: 2.76e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAE 104
Cdd:COG4235  31 GRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQK 110

                        90
                ....*....|
gi 23956176 105 GQKLDSTDTN 114
Cdd:COG4235 111 LLALLPADAP 120
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 21-112 3.21e-14

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 68.68  E-value: 3.21e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  21 ALIDGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALE 100
Cdd:COG4783  14 LLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALA 93

                        90
                ....*....|..
gi 23956176 101 TFAEGQKLDSTD 112
Cdd:COG4783  94 LLEKALKLDPEH 105
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 25-109 9.13e-14

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 68.06  E-value: 9.13e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAE 104
Cdd:COG5010  68 GDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQR 147


                ....*
gi 23956176 105 GQKLD 109
Cdd:COG5010 148 ALGTS 152
p23_melusin_like cd06488
p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related ...
 144-229 6.03e-13

p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta subunits. Melusin is a muscle-specific protein expressed in skeletal and cardiac muscles but not in smooth muscle or other tissues. It is needed for heart hypertrophy following mechanical overload. The integrin-binding portion of this domain appears to be sequestered in the full length melusin protein, Ca2+ may modulate the protein's conformation exposing this binding site. This group includes Chordc1, also known as Chp-1, which is conserved from vertebrates to humans. Mammalian Chordc1 interacts with the heat shock protein (HSP) Hsp90 and is implicated in circadian and/or homeostatic mechanisms in the brain. The N-terminal portions of proteins belonging to this group contain two cysteine and histidine rich domain (CHORD) domains.


Pssm-ID: 107238  Cd Length: 87  Bit Score: 63.47  E-value: 6.03e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176 144 KYDWYQTESHVIITLMIKSVQKNDVRVGFSERELSALVKIPAGEDYSLKLRLLHPIIPEQSTFKVLSTKIEIKMKKPEAV 223
Cdd:cd06488   2 RHDWHQTGSHVVVSVYAKNSNPELSVVEANSTVLTIHIVFEGNKEFQLDIELWGVIDVEKSSVNMLPTKVEIKLRKAEPG 81


                ....*.
gi 23956176 224 RWEKLE 229
Cdd:cd06488  82 SWAKLE 87
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 25-112 5.32e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 62.52  E-value: 5.32e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAE 104
Cdd:COG4783  52 GDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEK 131


                ....*...
gi 23956176 105 GQKLDSTD 112
Cdd:COG4783 132 ALELDPDD 139
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 25-109 6.04e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 65.14  E-value: 6.04e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAE 104
Cdd:COG2956 124 GDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALER 203


                ....*
gi 23956176 105 GQKLD 109
Cdd:COG2956 204 ALEQD 208
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 29-114 4.31e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 59.63  E-value: 4.31e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  29 AALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAEGQKL 108
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80


                ....*.
gi 23956176 109 DSTDTN 114
Cdd:COG4235  81 DPDNPE 86
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
38-112 4.45e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.33  E-value: 4.45e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23956176  38 LEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAEGQKLDSTD 112
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD 75
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 7-127 1.94e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.51  E-value: 1.94e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176   7 GPASSQRLFQSFSDALIDGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKG 86
Cdd:COG2956 140 GPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLA 219

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 23956176  87 ICEYHEKDYASALETFAEGQKLDSTDTNFDTWIKRCQEIQN 127
Cdd:COG2956 220 ELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEG 260
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 25-112 2.58e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 61.55  E-value: 2.58e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAE 104
Cdd:COG3914 126 GRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRR 205


                ....*...
gi 23956176 105 GQKLDSTD 112
Cdd:COG3914 206 ALELDPDN 213
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 8-107 2.59e-10

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 61.54  E-value: 2.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176     8 PASSQRLFQSFSDALIDGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGI 87
Cdd:TIGR00990 362 PRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFIFSHIQLGV 441

                          90       100
                  ....*....|....*....|
gi 23956176    88 CEYHEKDYASALETFAEGQK 107
Cdd:TIGR00990 442 TQYKEGSIASSMATFRRCKK 461
ACD_sHsps_p23-like cd00298
This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small ...
 147-219 3.85e-10

This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this family is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR).


Pssm-ID: 107219  Cd Length: 80  Bit Score: 55.67  E-value: 3.85e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176 147 WYQTESHVIITLMIKSVQKNDVRVGFSERELSALVKIPAGED-------YSLKLRLLHPIIPEQSTFKVLSTKIEIKMKK 219
Cdd:cd00298   1 WYQTDDEVVVTVDLPGVKKEDIKVEVEDNVLTISGKREEEEErersygeFERSFELPEDVDPEKSKASLENGVLEITLPK 80
p23_CacyBP cd06468
p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP) ...
 144-229 8.98e-10

p23_like domain found in proteins similar to Calcyclin-Binding Protein(CacyBP)/Siah-1-interacting protein (SIP). CacyBP/SIP interacts with S100A6 (calcyclin), with some other members of the S100 family, with tubulin, and with Siah-1 and Skp-1. The latter two are components of the ubiquitin ligase that regulates beta-catenin degradation. The beta-catenin gene is an oncogene participating in tumorigenesis in many different cancers. Overexpression of CacyBP/SIP, in part through its effect on the expression of beta-catenin, inhibits the proliferation, tumorigenicity, and invasion of gastric cancer cells. CacyBP/SIP is abundant in neurons and neuroblastoma NB2a cells. An extensive re-organization of microtubules accompanies the differentiation of NB2a cells. CacyBP/SIP may contribute to NB2a cell differentiation through binding to and increasing the oligomerization of tubulin. CacyBP/SIP is also implicated in differentiation of erythroid cells, rat neonatal cardiomyocytes, in mouse endometrial events, and in thymocyte development.


Pssm-ID: 107225  Cd Length: 92  Bit Score: 54.96  E-value: 8.98e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176 144 KYDWYQTESHVIITLMIKSVQ---KNDVRVGFSERELSALVKIPAGEDYSLKL-RLLHPIIPEQSTFKVLSTKIEIKMKK 219
Cdd:cd06468   3 KYAWDQSDKFVKIYITLKGVHqlpKENIQVEFTERSFELKVHDLNGKNYRFTInRLLKKIDPEKSSFKVKTDRIVITLAK 82

                        90
                ....*....|
gi 23956176 220 PEAVRWEKLE 229
Cdd:cd06468  83 KKEKKWESLT 92
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
39-114 3.52e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 56.08  E-value: 3.52e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 23956176  39 EQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAEGQKLDSTDTN 114
Cdd:COG4785  67 LALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAY 142
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 25-112 4.91e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 57.70  E-value: 4.91e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAE 104
Cdd:COG3914  92 GRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRR 171


                ....*...
gi 23956176 105 GQKLDSTD 112
Cdd:COG3914 172 ALELDPDN 179
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 25-109 2.10e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.35  E-value: 2.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAE 104
Cdd:COG2956  90 GLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEK 169


                ....*
gi 23956176 105 GQKLD 109
Cdd:COG2956 170 ALKLD 174
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 20-104 3.10e-08

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 51.15  E-value: 3.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  20 DALIDGDPQAALEELTKALEQNPD-----DAQYYcqRAYCHILLGKYRDGIADVKKSLELNPNN---CTALLRKGICEYH 91
Cdd:COG1729   2 ALLKAGDYDEAIAAFKAFLKRYPNsplapDALYW--LGEAYYALGDYDEAAEAFEKLLKRYPDSpkaPDALLKLGLSYLE 79

                        90
                ....*....|...
gi 23956176  92 EKDYASALETFAE 104
Cdd:COG1729  80 LGDYDKARATLEE 92
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 25-115 6.40e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.19  E-value: 6.40e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAE 104
Cdd:COG2956  56 GEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLER 135

                        90
                ....*....|.
gi 23956176 105 GQKLDSTDTNF 115
Cdd:COG2956 136 LLKLGPENAHA 146
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 25-82 1.29e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 53.07  E-value: 1.29e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 23956176  25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTAL 82
Cdd:COG3914 160 GRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAH 217
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 21-112 2.82e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.27  E-value: 2.82e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  21 ALIDGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALE 100
Cdd:COG2956  18 YLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEE 97

                        90
                ....*....|..
gi 23956176 101 TFAEGQKLDSTD 112
Cdd:COG2956  98 LLEKLLELDPDD 109
p23_DYX1C1_like cd06469
p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) ...
 147-229 3.16e-07

p23_like domain found in proteins similar to dyslexia susceptibility 1 (DYX1) candidate 1 (C1) protein, DYX1C1. The human gene encoding this protein is a positional candidate gene for developmental dyslexia (DD), it is located on 15q21.3 by the DYX1 DD susceptibility locus (15q15-21). Independent association studies have reported conflicting results. However, association of short-term memory, which plays a role in DD, with a variant within the DYX1C1 gene has been reported. Most proteins belonging to this group contain a C-terminal tetratricopeptide repeat (TPR) protein binding region.


Pssm-ID: 107226  Cd Length: 78  Bit Score: 47.27  E-value: 3.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176 147 WYQTESHVIITLMIKSVQKNDVRVGFSERelsaLVKIPAgEDYSLKLRLLHPIIPEQSTFKVLSTKIEIKMKKPEAVRWE 226
Cdd:cd06469   1 WSQTDEDVKISVPLKGVKTSKVDIFCSDL----YLKVNF-PPYLFELDLAAPIDDEKSSAKIGNGVLVFTLVKKEPGIWE 75


                ...
gi 23956176 227 KLE 229
Cdd:cd06469  76 ALC 78
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 44-112 3.28e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.03  E-value: 3.28e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23956176  44 DAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAEGQKLDSTD 112
Cdd:COG4783   3 CAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDE 71
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 20-114 3.46e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.19  E-value: 3.46e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  20 DALIDGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASAL 99
Cdd:COG5010  29 AALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAK 108

                        90
                ....*....|....*
gi 23956176 100 ETFAEGQKLDSTDTN 114
Cdd:COG5010 109 EYYEKALALSPDNPN 123
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 9-107 4.15e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 51.62  E-value: 4.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176     9 ASSQRLFQSFSDALI-DGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGI 87
Cdd:TIGR02917 598 PDSPEAWLMLGRAQLaAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQ 677

                          90       100
                  ....*....|....*....|
gi 23956176    88 CEYHEKDYASALETFAEGQK 107
Cdd:TIGR02917 678 LLLAAKRTESAKKIAKSLQK 697
p23_hB-ind1_like cd06465
p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. ...
 147-228 4.39e-07

p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. hB-ind1 participates in signaling by the small GTPase Rac1. It binds to Rac1 and enhances different Rac1 effects including activation of nuclear factor (NF) kappaB and activation of c-Jun N-terminal kinase (JNK). hB-ind1 also plays a part in the RNA replication and particle production of Hepatitis C virus (HCV) through its interaction with heat shock protein Hsp90, HCV nonstructural protein 5A (NS5A), and the immunophilin FKBP8. hB-ind1 is upregulated in the outer layer of Chinese hamster V79 cells grown as multicell spheroids, versus in the same cells grown as monolayers. This group includes the Saccharomyces cerevisiae Sba1, a co-chaperone of the Hsp90. Sba1 has been shown to be is required for telomere length maintenance, and may modulate telomerase DNA-binding activity.


Pssm-ID: 107222 [Multi-domain]  Cd Length: 108  Bit Score: 47.59  E-value: 4.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176 147 WYQTESHVIITLMIKSVQknDVRVGFSERELS-ALVKIPAGEDYSLKLRLLHPIIPEQSTFKVLSTKIEIKMKKPEA-VR 224
Cdd:cd06465   5 WAQRSDVVYLTIELPDAK--DPKIKLEPTSLSfKAKGGGGGKKYEFDLEFYKEIDPEESKYKVTGRQIEFVLRKKEAgEY 82


                ....
gi 23956176 225 WEKL 228
Cdd:cd06465  83 WPRL 86
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
25-77 2.80e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.16  E-value: 2.80e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 23956176  25 GDPQAALEeLTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPN 77
Cdd:COG3063  40 GRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPS 91
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 25-76 3.21e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.49  E-value: 3.21e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 23956176  25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNP 76
Cdd:COG5010 102 GDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 30-99 4.54e-06

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 48.06  E-value: 4.54e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176    30 ALEELTKALEQNPDDAqYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASAL 99
Cdd:TIGR00990 146 AIKLYSKAIECKPDPV-YYSNRAACHNALGDWEKVVEDTTAALELDPDYSKALNRRANAYDGLGKYADAL 214
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 25-102 6.56e-06

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 46.56  E-value: 6.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176    25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGkyRDGIAD--VKKSLELNPNNCTALLRKGICEYHEKDYASALETF 102
Cdd:TIGR02521  45 GDLEVAKENLDKALEHDPDDYLAYLALALYYQQLG--ELEKAEdsFRRALTLNPNNGDVLNNYGTFLCQQGKYEQAMQQF 122
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 25-104 1.41e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.00  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176    25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALETFAE 104
Cdd:TIGR02917 207 GNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKKNYEDARETLQD 286
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
25-99 1.80e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.38  E-value: 1.80e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23956176  25 GDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASAL 99
Cdd:COG0457 124 GRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLA 198
p23_NCB5OR cd06490
p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins. ...
 145-228 2.89e-05

p23_like domain found in NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR) and similar proteins. NCB5OR is widely expressed in human organs and tissues and is localized in the ER (endoplasmic reticulum). It appears to play a critical role in maintaining viable pancreatic beta cells. Mice homozygous for a targeted knockout (KO) of the gene encoding NCB5OR develop an early-onset nonautoimmune diabetes phenotype with a non-inflammatory beta-cell deficiency. The role of NCB5OR in beta cells may be in maintaining or regulating their redox status. Proteins in this group in addition contain an N-terminal cytochrome b5 domain and a C-terminal cytochrome b5 oxidoreductase domain. The gene encoding NCB5OR has been considered as a positional candidate for type II diabetes and other diabetes subtypes related to B-cell dysfunction, however variation in its coding region does not appear not to be a major contributor to the pathogenesis of these diseases.


Pssm-ID: 107240  Cd Length: 87  Bit Score: 41.93  E-value: 2.89e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176 145 YDWYQTESHVIITLMIKSVQKND--VRVGFSERELSALVKIpagED--YSLKLRLLHPiIPEQSTFKVLST--KIEIKMK 218
Cdd:cd06490   1 YDWFQTDSEVTIVVYTKSKGNPAdiVIVDDQQRELRVEIIL---GDksYLLHLDLSNE-VQWPCEVRISTEtgKIELVLK 76

                        90
                ....*....|
gi 23956176 219 KPEAVRWEKL 228
Cdd:cd06490  77 KKEPEKWTSL 86
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 45-78 6.14e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 39.74  E-value: 6.14e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 23956176     45 AQYYCQRAYCHILLGKYRDGIADVKKSLELNPNN 78
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
45-78 7.98e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 39.33  E-value: 7.98e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 23956176    45 AQYYCQRAYCHILLGKYRDGIADVKKSLELNPNN 78
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
54-112 9.32e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.84  E-value: 9.32e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 23956176  54 CHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALEtFAEGQKLDSTD 112
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNN 58
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 22-142 1.17e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.84  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176    22 LIDGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALET 101
Cdd:TIGR02917 340 LRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIAD 419

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 23956176   102 FAEGQKLDSTDTNFDTWIKrCQEIQNGSESEVSASQRTQSK 142
Cdd:TIGR02917 420 LETAAQLDPELGRADLLLI-LSYLRSGQFDKALAAAKKLEK 459
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 20-78 1.73e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 39.53  E-value: 1.73e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 23956176  20 DALIDGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNN 78
Cdd:cd24142   9 ELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDG 67
TPR_17 pfam13431
Tetratricopeptide repeat;
34-66 1.95e-03

Tetratricopeptide repeat;


Pssm-ID: 433201 [Multi-domain]  Cd Length: 34  Bit Score: 35.21  E-value: 1.95e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 23956176    34 LTKALEQNPDDAQYYCQRAYCHILLGKYRDGIA 66
Cdd:pfam13431   2 YLKALELDPNNADAYYNLAVLLLELGQSETALQ 34
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 45-77 3.15e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 34.81  E-value: 3.15e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 23956176    45 AQYYCQRAYCHILLGKYRDGIADVKKSLELNPN 77
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 7-77 3.38e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 3.38e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23956176     7 GPASSQRLFQSFSDALIDGDPQAALEELTKALEQNPDD--AQYYCQRAYchILLGKYRDGIADVKKSLELNPN 77
Cdd:TIGR02917  18 GDQSPEELIEAAKSYLQKNKYKAAIIQLKNALQKDPNDaeARFLLGKIY--LALGDYAAAEKELRKALSLGYP 88
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
26-111 3.66e-03

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 38.32  E-value: 3.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176  26 DPQAALEELTKALEQNPDDAQYY-CQRAYCHilLGKYRDGIADVKKSLE-LNPNNCTALLRKGICEYHEKDYASALETFA 103
Cdd:COG4700  71 DPGRELRELEKALEFADTVQNRVrLADALLE--LGRYDEAIELYEEALTgIFADDPHILLGLAQALFELGRYAEALETLE 148


                ....*...
gi 23956176 104 EGQKLDST 111
Cdd:COG4700 149 KLIAKNPD 156
PRK09782 PRK09782
bacteriophage N4 receptor, outer membrane subunit; Provisional
 23-78 4.04e-03

bacteriophage N4 receptor, outer membrane subunit; Provisional


Pssm-ID: 236624 [Multi-domain]  Cd Length: 987  Bit Score: 39.13  E-value: 4.04e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 23956176   23 IDGDPQAALEELTKALEQNPdDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNN 78
Cdd:PRK09782 588 IPGQPELALNDLTRSLNIAP-SANAYVARATIYRQRHNVPAAVSDLRAALELEPNN 642
p23_NUDC_like cd06467
p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) ...
 145-228 4.36e-03

p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) NUDC is needed for nuclear movement. AnNUDC is localized at the hyphal cortex, and binds NUDF at spindle pole bodies (SPBs) and in the cytoplasm at different stages in the cell cycle. At the SPBs it is part of the dynein molecular motor/NUDF complex that regulates microtubule dynamics. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) complex, through binding mNUDF, the regulatory beta subunit of PAF-AH(I). mNUDC is important for cell proliferation both in normal and tumor tissues. Its expression is elevated in various cell types undergoing mitosis or stimulated to proliferate, with high expression levels observed in leukemic cells and tumors. For a leukemic cell line, human NUDC was shown to activate the thrombopoietin (TPO) receptor (Mpl) by binding to its extracellular domain, and promoting cell proliferation and differentiation. This group also includes the human broadly immunogenic tumor associated antigen, CML66, which is highly expressed in a variety of solid tumors and in leukemias. In normal tissues high expression of CML66 is limited to testis and heart.


Pssm-ID: 107224  Cd Length: 85  Bit Score: 35.60  E-value: 4.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176 145 YDWYQTESHVIITLMI-KSVQKNDVRVGFSERELSalVKIPAGEDYsLKLRLLHPIIPEQSTFKVLSTK-IEIKM-KKPE 221
Cdd:cd06467   1 YSWTQTLDEVTVTIPLpEGTKSKDVKVEITPKHLK--VGVKGGEPL-LDGELYAKVKVDESTWTLEDGKlLEITLeKRNE 77


                ....*..
gi 23956176 222 AVRWEKL 228
Cdd:cd06467  78 GEWWPSL 84
TPR_19 pfam14559
Tetratricopeptide repeat;
24-78 4.69e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 35.25  E-value: 4.69e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 23956176    24 DGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNN 78
Cdd:pfam14559   1 EGDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDD 55
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 22-100 5.22e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 5.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23956176    22 LIDGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALE 100
Cdd:TIGR02917 578 LGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAIT 656
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 21-109 5.41e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 5.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23956176    21 ALIDGDPQAALEELTKALEQNPDDAQYYCQRAYCHILLGKYRDGIADVKKSLELNPNNCTALLRKGICEYHEKDYASALE 100
Cdd:TIGR02917 135 YLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALA 214


                  ....*....
gi 23956176   101 TFAEGQKLD 109
Cdd:TIGR02917 215 AYRKAIALR 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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