|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD1 |
cd17340 |
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ... |
45-440 |
0e+00 |
|
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340898 [Multi-domain] Cd Length: 394 Bit Score: 630.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 45 LSLMCFLGFGSYFCYDNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRIFGIRWGTVIFSCFVCIGQV 124
Cdd:cd17340 1 LFLMCFLGFGSYFCYDNPAALQKQFIEDMDINTSQFMLLYSVYSWPNVVLCFFGGFLIDRVFGIRLGTIIFSLLVLIGQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 125 IFALGGIFNAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYGKIEALlgS 204
Cdd:cd17340 81 IFALGALTNLFWLMLVGRFIFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSFARIGSTVNFNVMPPIYKRISDF--Y 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 205 AGHMTLGVTLMIGCITCIFSLICALALAYLDRRAEKILHKEQGKTGEVIKLRDIKDFSLPLILVFVICVCYYVAVFPFIG 284
Cdd:cd17340 159 SGYKSLGVALWIGAITCLFSLICAIILGLLDKRAERILKKESNKTGEVIKLSDVKDFPLSFWLICIICVFYYVAVFPFIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 285 LGKVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNIIWVLYAVAATLVSHMMLAFTFWNPWIAMCLLGFS 364
Cdd:cd17340 239 LGTVFFEEKYGFSPSEAAAVNSIVYIISAAASPVFGFLVDKVGRNILWVLIALVITLLGHLLLAFTFVNPLIAMVIMGIG 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21313266 365 YSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGYLLLEVFFIACVSLSLLAVVCLYLV 440
Cdd:cd17340 319 YSMLACALWPMVPLVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSILDKKGYLLLEVFFIACLCVSLIALIILYLV 394
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
48-438 |
3.60e-37 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 139.87 E-value: 3.60e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 48 MCFLGFGSYFCYDNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRiFGIRWGTVIFSCFVCIGQVIFA 127
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADR-FGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 128 LggiFNAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLygkieALLGSAGH 207
Cdd:cd06174 80 F---APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIL-----ASSLGFGW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 208 MTLGVTLMIGCITCIFslicALALAYLDRRAEKILHKEQGKTGEVIKLRDIKDFSLPLILVFVICVCYYVAVFPFIGLGK 287
Cdd:cd06174 152 RAVFLIAAALALLAAI----LLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 288 VFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTG--KNIIWVLYAVAATLVSHMMLAFTFWNPWIAMCLLGFSY 365
Cdd:cd06174 228 LFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIgrKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGL 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21313266 366 SLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDskGYLLLEVFFIACVSLSLLAVVCLY 438
Cdd:cd06174 308 GGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA--ATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
42-440 |
1.62e-30 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 121.91 E-value: 1.62e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 42 LVVLSLMCFLGFGSYFCYdnpAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRiFGIRWGTVIFSCFVCI 121
Cdd:COG2223 7 LLLATLAFFLAFGVWYLW---SVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDR-FGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 122 GQVIFALGgifNAFWLMELGRFVFGIG-GESLAVAQnTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYGkiea 200
Cdd:COG2223 83 GLLLLALA---VSYWLLLLLGLLLGIGgGGSFAVGI-ALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA---- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 201 llgsaghmTLGVTLMIGCITCIFSLICALALAYLDRRAEKILHKEQGKTGEVIKLRDIKDFslplILVFVICVCYYVAVF 280
Cdd:COG2223 155 --------AFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRF----WLLSLLYFGTFGSFI 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 281 PFIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTG-KNIIWVLYAVAAtlVSHMMLAFTFWNPW---I 356
Cdd:COG2223 223 GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGgRRVLLIVFALMA--LGLLLLALALGSLWlflV 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 357 AMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGylLLEVFFIACVSLSLLAVVC 436
Cdd:COG2223 301 LFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG--SYTAAFLVFAVLALVALVL 378
|
....
gi 21313266 437 LYLV 440
Cdd:COG2223 379 TLLL 382
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
34-442 |
6.20e-27 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 111.12 E-value: 6.20e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 34 DPSRLAHRLVVLSLMCFLGFGSYFCYDNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRiFGIRWGTV 113
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADR-FGRRRVLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 114 IFSCFVCIGQVIFALggiFNAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGW 193
Cdd:COG2271 80 IGLLLWGLATLLFGF---ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 194 LygkieallgsAGHMTLGVTLMIGCITCIFSLIcalalayldrraekilhkeqgktgeviklrdikdfsLPLILVFVICV 273
Cdd:COG2271 157 L----------LAAFGWRAAFLILGLPGLLLAL------------------------------------LRFWLLALAYF 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 274 CYYVAVFPFIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNIIWVLYAVAATLVSHMMLAFTFWN 353
Cdd:COG2271 191 LVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPS 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 354 PW---IAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGYlllEVFFIACVSLS 430
Cdd:COG2271 271 PAlaiALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY---QAAFLLLAALA 347
|
410
....*....|..
gi 21313266 431 LLAVVCLYLVNR 442
Cdd:COG2271 348 LLAALLALLLLR 359
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
35-399 |
4.83e-22 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 96.97 E-value: 4.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 35 PSRLAHRLVVLSLMCFLGFGSYFCYDNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRiFGIRWgtvi 114
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR-FGRRR---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 115 fscFVCIGQVIFALGGIFNAF----WLMELGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNL 190
Cdd:COG2814 77 ---VLLLGLLLFALGSLLCALapslWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 191 MGWLygkieallgsAGHMTLGVTLMIGCITCIFSLIcaLALAYLDRRAEKILHKEQGKTGEVIKLRdikdfslPLILVFV 270
Cdd:COG2814 154 GGLL----------ADLFGWRWVFLVNAVLALLALL--LLLRLLPESRPAARARLRGSLRELLRRP-------RLLLLLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 271 ICVCYYVAVFPFIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTG-KNIIWVLYAVAATLVSHMMLAF 349
Cdd:COG2814 215 LAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGrRRLLLIGLLLLALGLLLLALAG 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 21313266 350 TFWNPWIAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLG 399
Cdd:COG2814 295 SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
48-402 |
5.97e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 90.56 E-value: 5.97e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 48 MCFLGFGSYFCYDNPA-ALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRiFGIRWGTVIFSCFVCIGQVIF 126
Cdd:pfam07690 1 LFLAAFLAALGRSLLGpALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR-FGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 127 ALGgifNAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYgkieallgsag 206
Cdd:pfam07690 80 LFA---SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA----------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 207 hmTLGVTLMIGCITCIFSLICALALAYLDRRAEKILHKEQGKTGEVIKLRdIKDFSLPLILVFVICVCYYVAVFPFIGLG 286
Cdd:pfam07690 146 --SLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA-WKALLRDPVLWLLLALLLFGFAFFGLLTY 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 287 KVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNIIWVL--YAVAATLVSHMMLAFTFWNPW--IAMCLLG 362
Cdd:pfam07690 223 LPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLalLLLILAALGLLLLSLTLSSLWllLALLLLG 302
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 21313266 363 FSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAV 402
Cdd:pfam07690 303 FGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
82-435 |
1.30e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 84.16 E-value: 1.30e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 82 LLYAWYSWPNVVLCFLGGFLIDRiFGIRWGTVIFSCFVCIGQVIFALggiFNAFWLMELGRFVFGIGGESLAVAQNTYAV 161
Cdd:cd17325 35 LIVAAYALAQLLFSPPAGRLSDR-FGRKRLLLLGLLLLAVSTLLFAF---ATSYWQLLLARFLQGLASAAVWPAAMALIA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 162 SWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYGK--IEALLGSAGhmtlgvtlmigcitcIFSLICALALAYLDRRAE 239
Cdd:cd17325 111 DIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAlgYRAPFLVCA---------------ALALLALVLALLLLPEPR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 240 KILHKEQGKTGEVIKLRDIKDFSLPLILVFVICVCYYVAVFPFIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMSPLF 319
Cdd:cd17325 176 PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 320 GLLVDKTGKNIIwVLYAVAATLVSHMMLAF--TFWNPWIAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQN 397
Cdd:cd17325 256 GKLSDRIGRKPL-ILIGLLLSAVALLLLPLatSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFS 334
|
330 340 350
....*....|....*....|....*....|....*...
gi 21313266 398 LGLAVIAILAGMILDSKGYLLLevfFIACVSLSLLAVV 435
Cdd:cd17325 335 LGMVLGPLLGGFLYDAFGFATP---FLAAAALLLLAAV 369
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
41-435 |
5.00e-16 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 79.15 E-value: 5.00e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 41 RLVVLSLMCFLGFGSYFCYDNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRiFGIRWGTVIFSCFVC 120
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDR-FGARKVLAVSMLLWS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 121 IGQVIFALGGIFNAFWLMelgRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLygkiea 200
Cdd:cd17319 80 LFTALTGFATSLTSLYVL---RFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL------ 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 201 lLGSAG-HMTLGVtlmIGCITCIFSLICALALayldRRaekilhkeqgktgeviklrdikdfslpLILVFVICVCYYVAV 279
Cdd:cd17319 151 -LLLFGwRWAFII---EGLLGLLLAVLWWFYL----RQ---------------------------VWGLALGYFGINYAL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 280 FPFIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTG----KNIIWVLYAVAATLvshMMLAFTFWNPW 355
Cdd:cd17319 196 YGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLrgarRLVIIIGLLLAAVG---LLLAYLTTSPV 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 356 IAMCLLGFSYSLLACA---LWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDSKG-YLLLEVFFIACVSLSL 431
Cdd:cd17319 273 VAVILLSLAGFGIGAAspvFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAA 352
|
....
gi 21313266 432 LAVV 435
Cdd:cd17319 353 LLVL 356
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
97-439 |
3.74e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 71.09 E-value: 3.74e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 97 LGGFLIDRiFGIRWGTVIFscFVCIGQVIFALGGI--FNAFWLMELGRFVFGIGGESLA-VAQNTYAVSWF--------K 165
Cdd:COG2211 65 LIGALSDR-TRTRWGRRRP--WILIGAIPLALSFVllFTAPDLSPTGKLIYALVTYLLLgLAYTLVNIPYSalgaeltpD 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 166 GKELNLVFGLQLSMARIGSTVNMNLMGWLygkIEALLGSAGHMTLGVTLMIGCITCIFSLICALALAyldrraEKILHKE 245
Cdd:COG2211 142 YEERTRLSSWRFAFAGLGGLLASVLPPPL---VAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTK------ERPVPEE 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 246 QGKTGevikLRDIKDF--SLPLILVFVICVCYYVAVFPFIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLV 323
Cdd:COG2211 213 EKVSL----KESLKALlkNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLA 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 324 DKTGKNIIWVLYAVAATLVSHMMLAFTFWNPW---IAMCLLGFSYSLLACALWPMVAFIVPEHQL-------GTAYGFMQ 393
Cdd:COG2211 289 KRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWlllVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFT 368
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 21313266 394 SIQNLGLAVIAILAGMILDSKGY------------LLLEVFFIACVSLSLLAVVCLYL 439
Cdd:COG2211 369 FAIKLGQALAGALAGLLLALFGYvagaaqspsaltGIRLLFFLLPAVLLLLAALLLLF 426
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
66-435 |
5.30e-13 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 70.44 E-value: 5.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 66 QTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRiFGIRwgtVIFSCFVCIGQVIFALGGIFNAFWLMELGRFVF 145
Cdd:TIGR00893 17 APMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDR-FGAR---KTLAVFIVIWGVFTGLQAFAGAYVSLYILRVLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 146 GIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYgkieallgsaGHMTLGVTLMIGCITCIFSL 225
Cdd:TIGR00893 93 GAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWIL----------IHFSWQWAFIIEGVLGIIWG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 226 ICALALAYLDRRAEKILHKE-------------QGKTGEVIKLRDIKD--FSLPLILVFVICVCYYVAVFPFIGLGKVFF 290
Cdd:TIGR00893 163 VLWLKFIPDPPQKAKWLTEEekyivvggllaeqQGKGPSTPKKYQIKEllKDRRVWGLALGQFLVNIGLGFFLTWFPTYL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 291 MEKFRFSSQSASAINSIVYIISAPMSPLFGLLVD---KTGKNIIWVLYAVAATLVSHMMLAFTF---WNPWIAMCL--LG 362
Cdd:TIGR00893 243 VQERGLSILEAGFMASLPGIVGFIGMILGGRLSDlllRRGKSLVFARKTAIIAGLVLSLLMFATnyvNIPYAALALvaLG 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21313266 363 FSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGY----LLLEVFFIACVSLSLLAVV 435
Cdd:TIGR00893 323 FFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSfagaLMVVAALALIGALSYLLLV 399
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
35-444 |
3.01e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 67.96 E-value: 3.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 35 PSRLAHRLVVLSLMCFLGFGsyFCYDNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRiFGIRWGTVI 114
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWG--FATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDR-FGYKRGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 115 FSCFVCIGQVIFALGGifnAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMArIGSTVNMNLMGWL 194
Cdd:COG0738 79 GLLLMALGLLLFALAP---SYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFS-LGALLGPLLGGLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 195 ygkieallgSAGHMTLGVTLMIGCITCIFSLICALALAYLDRRAEKILHKEQGKTGEVIKLrdikdFSLPLILVFVICVC 274
Cdd:COG0738 155 ---------ILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSL-----LKNPRLLLGGLAIF 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 275 YYVAV-FPFIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNIIWVLYAVAATLVshMMLAFTFWN 353
Cdd:COG0738 221 LYVGAeGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG--LLLALLAPG 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 354 PWIAM---CLLGFSYSLLACALWPMVAFIVPEHQlGTAYGFMQSIQNLGLAVIAILAGMILDSKGYLLLEVFFIACVSLS 430
Cdd:COG0738 299 PWLALiglALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLI 377
|
410
....*....|....
gi 21313266 431 LLAVVCLYLVNRAQ 444
Cdd:COG0738 378 LLLALALKRKRRKK 391
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
265-434 |
9.84e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 63.00 E-value: 9.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 265 LILVFVICVCYYVAVFPFIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNIIWVLYAVAATLVSH 344
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILAL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 345 MMLAFTFWNPW---IAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGYLLLEV 421
Cdd:cd17316 259 PLFYLLSGSPTlllLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPA 338
|
170
....*....|...
gi 21313266 422 FFIACVSLSLLAV 434
Cdd:cd17316 339 LILALLAIVALIV 351
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
92-439 |
1.19e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 62.98 E-value: 1.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 92 VVLCFLGGFLIDRiFGIRWgtvifscFVCIGQVIFALGGI----FNAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGK 167
Cdd:cd17473 49 ALFAPLAGWLADR-FGRKR-------LLIAGLLLYGIGGVaglfLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 168 ELNLVFGLQLSMARIGSTVNMNLMGWLygkieALLGSagHMTLGVTLmigcitciFSLICALALAYLDRRAEKILHKEQG 247
Cdd:cd17473 121 ERAKMLGLQSAAMSLGGVVFLLLGGAL-----AEIGW--RAPFLVYL--------LALPVLILVLLFLPEPARKSKSAAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 248 KTGEVIKLRDIKDFSLPLILVFVICVCYYVAV--FPFiglgkvFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDK 325
Cdd:cd17473 186 PGAATAAALPWKRVLPIYFLAFLAMLLFYVIPiqLPF------LLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 326 TGKNIIWVLyAVAATLVSHMMLAFTFWNPWIAMCLL--GFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVI 403
Cdd:cd17473 260 LGKRRLLAI-GFALMALGFLLLALASGLWVVLLGAIlaGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLS 338
|
330 340 350
....*....|....*....|....*....|....*.
gi 21313266 404 AILAgMILDSKGYLLLEVFFIACVSLSLLAVVCLYL 439
Cdd:cd17473 339 PLVL-GPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
268-442 |
6.80e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 57.43 E-value: 6.80e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 268 VFVICVCYYVAVFPFIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTG-KNIIWVLYAVAATLVSHMM 346
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGrRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 347 LAFTFWNPWIAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGYlllEVFFIAC 426
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGW---RAAFLIL 157
|
170
....*....|....*.
gi 21313266 427 VSLSLLAVVCLYLVNR 442
Cdd:pfam07690 158 AILSLLAAVLLLLPRP 173
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
42-434 |
1.37e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 56.40 E-value: 1.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 42 LVVLSLMCFLGFGSYFCydnPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRiFGIRWGTVIFSCFVCI 121
Cdd:cd17324 1 LLALALAAFAIGTTEYV---IQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDR-IERRRLLLVLLLLFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 122 GQVIFALGgifNAFWLMELGRFVFGIGGESLAVAQNTYAVSWF----KGKELNLVF-GLQLSM--ARIGSTVNMNLMGWl 194
Cdd:cd17324 77 GNLLAALA---PSFALLLLARALAGLAHGGFWAIAAAYAADLVppekRGRAIGLVFsGLTLGLvlGRPLGGLLGQLLGW- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 195 ygkieallgsagHMTLGvtlmigcitcIFSLICALALAYLDRRAEKILHKEQGKTGEVIKLRDI-KDFSLPLILVFVICV 273
Cdd:cd17324 153 ------------RAAFL----------AIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLlRNPRLRLAYLITFLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 274 -CYYVAVFPFIGLgkvFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNIIWVLYAVAATLvshmMLAFTFW 352
Cdd:cd17324 211 fGGFFALYTYLAP---FLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA----LLLLTLL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 353 NPW-----IAMCLLGFSYSLLACALWPMVAFIVPEHQlGTAYGFMQSIQNLGLAVIAILAGMILDSKGYLLLEVFFIACV 427
Cdd:cd17324 284 GPSpllllVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALL 362
|
....*..
gi 21313266 428 SLSLLAV 434
Cdd:cd17324 363 LLALLLA 369
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
288-462 |
2.02e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 55.90 E-value: 2.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 288 VFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTG-KNIIWVLYAVAATLVSHMMLAFTFWNPWIAMCLLGFSYS 366
Cdd:cd06174 20 PALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGrRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 367 LLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGYLLLEVFFIACVSLSLLAVVCLYLVNRAQGG 446
Cdd:cd06174 100 LIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPES 179
|
170
....*....|....*.
gi 21313266 447 NLNYSAKQRERMKLSH 462
Cdd:cd06174 180 ARAKNEEASSKSVLKL 195
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
92-435 |
5.04e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 54.91 E-value: 5.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 92 VVLCFLGGFLIDRIFGIRwgtvifscFVCIGQVIFALGGIF----NAFWLMELGRFVFGIGGESLAVAQNTYAVsWFKGK 167
Cdd:cd17489 45 LLARPFAGRLLDRFGRKR--------LLLIGLLIFALATLLyllaTSVALLLVLRLIHGIGWGAFTTAAATLVA-DIIPP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 168 ELNlvfGLQLSMARIGSTVNMNLMGWLYGKIEALLGSAGHMTLGVTLMIGcitcifslicALALAYLDRRAEKILHKEQG 247
Cdd:cd17489 116 SRR---GEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL----------ALLLVFLVKDPPPVAAEEAE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 248 KTGEVIKLRDIKDFSLPLILVFVICVCYYVAVFpFIGLgkvFFMEKFrfssQSASAINSIVYIISAP-MSPLFGLLVDKT 326
Cdd:cd17489 183 AGTRAFRRLVEKKVLPPALILFLASIAYGAIST-FLPL---YAAERG----ISNAGLFFTVYAIALLlSRPFSGKLSDRK 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 327 GKNiiWVLYaVAATLVSHMMLAFTF-WNPW---IAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAV 402
Cdd:cd17489 255 GPK--TVII-PGLLLLALGLLLLSFaGSPWmllLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGL 331
|
330 340 350
....*....|....*....|....*....|...
gi 21313266 403 IAILAGMILDSKGYlllEVFFIACVSLSLLAVV 435
Cdd:cd17489 332 GGLLLGLVAELFGY---RAMFLLAAVVVLLALV 361
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
43-440 |
9.10e-08 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 54.18 E-value: 9.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 43 VVLSLMCF-LGFGSYFcydNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRIFGIRWGTvIFSCFVCI 121
Cdd:cd17341 1 LHLSWLSFfLGFMVWF---LFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFI-ASLLLLLI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 122 GQVIFALGGifNAFWLMELGRFVFGIGGESLAVAQnTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYGKIEAL 201
Cdd:cd17341 77 PLLALALAV--SSYWGLLVLGFLLGFAGANFASGQ-PWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFD 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 202 LGSAG-HMTLGVTLmigcitcIFSLICALALAYLDRRAekilhkEQGKTGEVIKLRDIKDfSLPLILVFVICVCYYVAVF 280
Cdd:cd17341 154 GGFVGwRNAFFVPG-------ILLAIAAVLVLLFGDDL------PTGKASALEFLKVQLA-VLKNYRTWILSLLYGVTFG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 281 PFIGLGKVF---FMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKN----IIWVLYAVAATLVSHM--MLAFTF 351
Cdd:cd17341 220 SFVGFSNVLptyFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRrrlwWLFIVMTIGAALLSLSlpTSGTNL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 352 WNPWIAMCLLGFSYSLLACALWPMVAFIVPEhQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGYlllevFFIACVSLSL 431
Cdd:cd17341 300 VLFLALFVALGLGAGAGNGSVFRMVPFIFRR-ELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGS-----GVGAFSLFGV 373
|
....*....
gi 21313266 432 LAVVCLYLV 440
Cdd:cd17341 374 LAVACTLLV 382
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
93-444 |
1.60e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 53.34 E-value: 1.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 93 VLCFLGGFLIDRiFGIRWGTVIFSCFVCIGQVIFALGGifnAFWLMELGRFVFGIGGESLAVAQNTYAVSWFkGKELNLV 172
Cdd:COG2807 68 LFAPLAPRLARR-FGLERTLLLALLLLAAGLLLRSLAP---SVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLM 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 173 FGLQLSMARIGSTVNMNLMGWLygkiealLGSAG-HMTLGvtlmigcITCIFSLICALALAYLDRRAEKILHKEQGKTGE 251
Cdd:COG2807 143 TGLYTAAMGLGAALAAGLTVPL-------AAALGwRGALA-------VWALLALLALLLWLPLLRRRPAAAAAAPAAASL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 252 VIKLRDIKDFSLPLILvFVICVCYYvAVFPFIglgkVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNII 331
Cdd:COG2807 209 RSLWRSPLAWLLTLFF-GLQSLLYY-AVVAWL----PPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRP 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 332 WVLYAVAATLVSHMMLAFTF-WNPWIAMCLLGFSYSllacALWPMVAFIVPEH-----QLGTAYGFMQSIQNLGLAVIAI 405
Cdd:COG2807 283 LLLLLGLLGLAGLLGLLLAPgSLPWLWAVLLGLGQG----GLFPLALTLIGLRartpaEAAALSGMAQSVGYLLAALGPL 358
|
330 340 350
....*....|....*....|....*....|....*....
gi 21313266 406 LAGMILDSKGYllLEVFFIACVSLSLLAVVCLYLVNRAQ 444
Cdd:COG2807 359 LVGALHDATGS--WTAALLLLAALAVLMLVAGLLAGRPY 395
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
288-440 |
3.48e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.21 E-value: 3.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 288 VFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKT----GKNIIWVLY-AVAATLVSHMMLAFTFWNPW------- 355
Cdd:COG2211 35 YFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTrtrwGRRRPWILIgAIPLALSFVLLFTAPDLSPTgkliyal 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 356 IAMCLLGFSYSLLACALWPMVAFIVPE-HQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGYLLLEVFFIACVSLSLLAV 434
Cdd:COG2211 115 VTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGL 194
|
....*.
gi 21313266 435 VCLYLV 440
Cdd:COG2211 195 LAFLLT 200
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
50-399 |
4.02e-07 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 51.92 E-value: 4.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 50 FLGFGSYFcydNPAALQTQ-VKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRIfGIRWGTVIFSCFVCIGQVIFAL 128
Cdd:TIGR00886 11 FLSFLVWF---AFSPLAVFlIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIF-GPRYTTALSLLLLAIPCLWAGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 129 GGifNAFWLMELGRFVFGIGGESLAVAQnTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYGKIEALLGSAGHM 208
Cdd:TIGR00886 87 AV--QSYSVLLLIRLFIGIAGGSFASCM-PWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSLIFGGGQPAHL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 209 TLGVTLMIGcITCIFSLICALALAYLDRraekilHKEQGKTGEVIKLRDIKDFSLPLiLVFVICVCYYVAVFPFIGLGKV 288
Cdd:TIGR00886 164 AWGWAFVIV-PAGILLLPALLIFFVGAD------TPPGKPATGKLSFKEALKVFGNR-HTWILALLYSVTFGSFLGVSSI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 289 F---FMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNIIWVLYAVAATLVSHMMLAFTFWNPWIAMCLLGFSY 365
Cdd:TIGR00886 236 FamlFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLAAFIVLFVA 315
|
330 340 350
....*....|....*....|....*....|....*....
gi 21313266 366 SLLAC-----ALWPMVAFIVPeHQLGTAYGFMQSIQNLG 399
Cdd:TIGR00886 316 LFFFAgagngSTFALVPHIFR-RATGAVSGLIGAIGNLG 353
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
255-440 |
4.98e-07 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 51.40 E-value: 4.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 255 LRDIKDFSLPLILVFVIC--VCYYVavfPFIGLgkVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNIIW 332
Cdd:cd17352 177 LRLLKDPTFVLLALGVSFamLGFFV---PFVYL--PSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLY 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 333 V-LYAVAATLVSHMM--LAFTFWNPWIAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGM 409
Cdd:cd17352 252 LyIFTLLILGLSLLAfpLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGL 331
|
170 180 190
....*....|....*....|....*....|.
gi 21313266 410 ILDSKGYLLleVFFIACVSLSLLAVVCLYLV 440
Cdd:cd17352 332 LRDYTGDYD--AAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
265-440 |
6.10e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.42 E-value: 6.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 265 LILVFVICVCYYVaVFPFIGLgkvfFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGK--NIIW--VLYAVAAT 340
Cdd:cd17325 2 SLALFLDMLGYGI-IIPILPL----YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRkrLLLLglLLLAVSTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 341 LvshMMLAFTFWNPWIAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGYLLLe 420
Cdd:cd17325 77 L---FAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAP- 152
|
170 180
....*....|....*....|
gi 21313266 421 vfFIACVSLSLLAVVCLYLV 440
Cdd:cd17325 153 --FLVCAALALLALVLALLL 170
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
226-435 |
7.76e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 51.00 E-value: 7.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 226 ICALALAYLDRRAEKILHKEQGKTGEVIKLRDIKDFSLPLILVFVICVCYYVAVFPFIGLGKVFFmekfrfSSQSASAIN 305
Cdd:cd17370 167 LLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRAQELGL------SAALIPLLY 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 306 SIVYIISAPMSPLFGLLVDKTG-KNIIWVLYAVAATLVSHMMLAFTFWNPWIAMCLLGFSYSLLACALWPMVAFIVPEHQ 384
Cdd:cd17370 241 ALFNLVYALAAYPAGRLSDRIGrKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAEL 320
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 21313266 385 LGTAYGFMQSIQNLGLAVIAILAGMILDSKGYLLLEVFFIACVSLSLLAVV 435
Cdd:cd17370 321 RGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
289-463 |
2.51e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.20 E-value: 2.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 289 FFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNIIwVLYAVAATLVSHMMLAFTfWNPW---IAMCLLGFSY 365
Cdd:COG2814 35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRV-LLLGLLLFALGSLLCALA-PSLWlllAARFLQGLGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 366 SLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGYLLLevfFIACVSLSLLAVVCLYLVNRAQG 445
Cdd:COG2814 113 GALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV---FLVNAVLALLALLLLLRLLPESR 189
|
170
....*....|....*...
gi 21313266 446 GNLNYSAKQRERMKLSHP 463
Cdd:COG2814 190 PAARARLRGSLRELLRRP 207
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
93-435 |
5.27e-06 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 48.38 E-value: 5.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 93 VLCFLGGFLIDRIFGIRWG---TVIFSCFVCIGQVIFALG--GIFNAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGK 167
Cdd:cd17485 45 VLKFLWAPLVDRYGLPRLGrrrSWLLPTQLGLALLLLALAflPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPE 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 168 ELNLVFGLQLSMARIGSTVNMNLMGWLYGKIeallgsaghmtlGVTLMIGCITCIfSLICALALayLDRRAEKILHKEQG 247
Cdd:cd17485 125 ERGLGNAAQVVGYKLGSLLGGGGLLWLYDLI------------GWQSLLLSLAAL-YLLLLLPV--LFLRELELPQQPPA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 248 KTGEVIKLRDIKDF-----SLPLILVfviCVCYYVAVFPFIGLGKVFFMEKfRFSSQSASAINSIV-YIISAPMSPLFGL 321
Cdd:cd17485 190 SERGAALKASLRAFlrrpgTRWLLLF---LLLYKLGEQGALAMLPPFLVDR-GFSLSQIGLLSGVGgSLVSIAGSLLGGY 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 322 LVDKTGKN--IIWVLYAVAATLVSHMMLAFTFWNPW-----IAMCLLGFSYSLLACALWP-MVAFIVPEHQlGTAYGFMQ 393
Cdd:cd17485 266 LLKRRGRRrlLLLGGLLRLLLLGLYTLLALGGSGLNwvlllASLALLHLVGGMITTALFTlMMDCSQQAQA-GTDYTLLA 344
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 21313266 394 SIQNLGLAVIAILAGMILDSKGYlllEVFFIACVSLSLLAVV 435
Cdd:cd17485 345 TVEVLGKLLFGSLAGFLADHLGY---AAAFLLFAILSALSVL 383
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
121-410 |
5.75e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 48.32 E-value: 5.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 121 IGQVIFALG----GIFNAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLyg 196
Cdd:cd17321 66 IGLALFGLAsllcALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLL-- 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 197 kiealLGSAG-HMTLGVTLMIGCItcifslicALALAyldrraekilhkeqgktgeviklrdiKDFSLPLILVFVICVCY 275
Cdd:cd17321 144 -----LELFGwRWIFLINVPIGLV--------ALLLA--------------------------RTFSGAVLAAFLLGAAL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 276 YVAVFPFIglgkVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNII----WVLYAVAATLVSHMMLAFTF 351
Cdd:cd17321 185 GGLLFLLP----LYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVlvagLLLTAVGLLLLALLGADSSV 260
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 352 WNPWIAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAV-IAILAGMI 410
Cdd:cd17321 261 WLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALgVALLGALL 320
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
99-438 |
1.35e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.17 E-value: 1.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 99 GFLIDRiFGIRWGTVIFscfVCIGQVIFALGGIFNAFWLMELGRFVFGIGG-----ESLAVAQNTYAVSWFKGKELNLVF 173
Cdd:cd17478 52 GYLADR-KPRRYLLPLG---PLLTGLGLSLLGFAPNYWLLLLLVALAGIGSaafhpEGARLASQAAGGRRGLAMSIFSVG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 174 GlqlsmaRIGSTVNMNLMGWLYgkieALLGSAGhmtlgvtlmigciTCIFSLICALALAYLDRRAEKILHKEQGKTGEVI 253
Cdd:cd17478 128 G------NLGFALGPLIAAALV----ALFGGLG-------------LLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 254 KLRD-IKDFSLPLILVFVICVCYYVAVFPFIGLGKVFFMEKFrFSSQSASAINSIVYIISAPMSPLFGLLVDKTG-KNII 331
Cdd:cd17478 185 SARStLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG-YSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGrRRVI 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 332 WVLYAVAATLVSHMMLAFTFWNpWIAMCLLGFsyslLACALWP----MVAFIVPEHqLGTAYGFMQSIQNLGLAVIAILA 407
Cdd:cd17478 264 IASLLLAAPFLLLFLLTPGIWS-YILLVLAGF----LLFASFPvtvvLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVL 337
|
330 340 350
....*....|....*....|....*....|.
gi 21313266 408 GMILDSKGyllLEVFFIACVSLSLLAVVCLY 438
Cdd:cd17478 338 GALADAFG---LESVLLILALLPLLGALLAF 365
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
96-434 |
1.70e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 46.85 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 96 FLGGFLIDRiFGIRWgtVIFSCFVCIGqVIFALGGIFNAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGL 175
Cdd:cd17475 49 LPAGWLLDR-FGERR--VLAVGLLLMG-AAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGI 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 176 QLSMARIGSTVNMNLMGWLygkieallgsAGHMTLGVTLMIGCITCIFSLICALALaYLDRRAEKilHKEQGKTGEVIKL 255
Cdd:cd17475 125 RQTGVPLGGALAAALLPPL----------ALHYGWRAAFVVAGLVSILAAVLFWLF-YREPPAAS--AATESASTLLRSL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 256 RDIKdFSLPLILVFVICVCYYVAVFPFIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKN-----I 330
Cdd:cd17475 192 KEVL-RNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGrrrpvL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 331 IWVLYAVAATLVSHMMLAF--TFWNPWIAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAG 408
Cdd:cd17475 271 VITAAIAAAALLVLSLLSPgtPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFG 350
|
330 340
....*....|....*....|....*..
gi 21313266 409 MILD-SKGYLLLEVFFIACVSLSLLAV 434
Cdd:cd17475 351 LLVDaTHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
119-440 |
2.94e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 46.03 E-value: 2.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 119 VCIGQVIFALGGIF----NAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWL 194
Cdd:cd17320 67 LLAGLLLFILASLLcalaSSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLL 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 195 ygkiealLGSAGHMTLGVTLMigcitcifsLICALALAYLDRRAEKILHKEQGKTGEVIKLRDIKD-FSLPLILVFVICV 273
Cdd:cd17320 147 -------LLFFGWRAIFVFLA---------LLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRvLKNRRFLGYALAL 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 274 -CYYVAVFPFIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTG-KNIIWV-----LYAVAATLVSHMM 346
Cdd:cd17320 211 gLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGpRRLLRLgllllLAAALVLLLAALL 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 347 LAFTFWNPWIAMCLLGFSYSLL--ACALWPMVAFivpEHQLGTAYGFMQSIQNLGLAVIAILAGMILDskGYLLleVFFI 424
Cdd:cd17320 291 GGLSLWPLVAPLFLIFFGFGLIfpNATSLALEPF---PHVAGTASALLGFLQFLIGALAGALVGLLPN--GTAL--PMGL 363
|
330
....*....|....*.
gi 21313266 425 ACVSLSLLAVVCLYLV 440
Cdd:cd17320 364 LILVLGLLALLLLILL 379
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
181-416 |
3.85e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 45.67 E-value: 3.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 181 RIGSTVNMNLMGWLYGKIEALLG--SAGHMTLGVTLMIGCITCIFSLICALalayldRRAEKILHKEQGKTGEVIK--LR 256
Cdd:cd17332 142 MFFATIGGLLVTVLPPPLVAYFGggNASRGYFLTALIIGIIGIILLLICFF------GTRERVVPPEEEKSKLPLLksLK 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 257 DIKDFsLPLILVFVICVCYYVAVFPFIGLGKVFFMEKFRFSSQSASAINSIVyIISAPMSPLFGLLVDKTGKNIIWVLYA 336
Cdd:cd17332 216 ALLKN-RPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLIL-SGALLALLPWPPLKKRFGKKKAFFIGL 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 337 VAATLVSHMMLAFTFWNPW---IAMCLLGFSYSLLACALWPMVAFIVPEHQL-------GTAYGFMQSIQNLGLAVIAIL 406
Cdd:cd17332 294 LLAILGLLLLFFLPPGNLVlilVLAVLAGIGYGGANLLPWAMLADVIDYGELktgkrreGIFYSVMTFFRKLGLALAGAL 373
|
250
....*....|
gi 21313266 407 AGMILDSKGY 416
Cdd:cd17332 374 VGLILSLAGY 383
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
91-434 |
7.49e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.91 E-value: 7.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 91 NVVLCFLGGFLIDRiFGIRWgTVIFSCFVCIgqVIFALGGIFNAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGKELN 170
Cdd:cd17329 48 GIVASLIGGRLADR-FGRKP-VMLAGLLLRA--LGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRT 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 171 LVFGLQLSMARIGSTVNMNLMGWLYGKIEALLgsaghmtlgvtLMIGCITCIFSLICALALAYLDRRAEKILHKEQGKTG 250
Cdd:cd17329 124 RAFSLLYWAINLGVAIGPLLGGLLLLYSFRLL-----------FLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRG 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 251 EVIKLRDIkdfslPLILVFVICVCYYVAVFPFIGLGKVFFMEKFRFSSQSAS---AINSIVyiISAPMSPLFGLLVDKTG 327
Cdd:cd17329 193 YKIVLRDR-----AFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGlllALNALL--IVLLQFPVARLVERFRL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 328 KNIIWVLYAVAAtlVSHMMLAF--TFWNPWIAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAI 405
Cdd:cd17329 266 RKILMIGILLFA--IGFAVLAFanTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPL 343
|
330 340
....*....|....*....|....*....
gi 21313266 406 LAGMILDSKGYLLLEVFFIACVSLSLLAV 434
Cdd:cd17329 344 VGGLLLDLLGPGLPWLILAALGLIAAALL 372
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
41-239 |
8.81e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 44.49 E-value: 8.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 41 RLVVLSLMCFLGFGSYFCYDN--PAALQTQVKRDMQVnttkFMLLYAWYSWPNVVLCFLGGFLIDRIFGIRWGTVIFS-C 117
Cdd:COG2223 206 RFWLLSLLYFGTFGSFIGFSSwlPPYLVDQFGLSAAT----AGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFAlM 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 118 FVCIGQVIFALGGIFNAFWLMELgrFVFGIGGESLAVAQntYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYgk 197
Cdd:COG2223 282 ALGLLLLALALGSLWLFLVLFLL--LGLALGGGNGAVFA--LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL-- 355
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 21313266 198 ieallGSAGHMTLGvtLMIGCITCIFSLICALALAYLDRRAE 239
Cdd:COG2223 356 -----DATGSYTAA--FLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
226-436 |
1.00e-04 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 44.59 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 226 ICALALAYLDRRAEKILHKEQGKTGEVIK---LRDIKDFSLPLILVFVICVCYYVAVFPFIGLGKVFFMEKFRFSSQSAS 302
Cdd:cd17367 183 VLAVVVLWLRRGLEETESFEAIAESNEASagtLRELRRHPRELLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDAT 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 303 AINSIVYIISAPMSPLFGLLVDKTGKNIIWVLYAVAATLVSHMMLAF--TFWNPWIAMCLLGFSYSLLAC--ALWPMV-A 377
Cdd:cd17367 263 WITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSAldHTDSPYTAFALVLVGLVFLSGytSINAVVkA 342
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21313266 378 FIVPEH--QLGTAYGFmqsiqnlGLAViAILAG----MILDSKGYLLLEVFFIACVSLSLLAVVC 436
Cdd:cd17367 343 ELFPTHvrALGVGLPY-------ALAV-AIFGGtapyVALWLKSIGHEWVFFWYVAGLIAISLVV 399
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
95-440 |
1.03e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 44.52 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 95 CFLGGFLIDRiFGIRWGTVIFSCFVCIGqviFALGGIFNAFWLMELGRFVFGIGGESLA--VAQNTyAVSWFKgkelnlv 172
Cdd:cd17353 55 APFAGRLVDR-GGPRKAILIGGILFGLG---FILSAFAISLPLLFLGYGVLGGIGAGIGyiTPVST-AVKWFP------- 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 173 fglqlsmARIGSTVNMNLMGWLYGK------IEALLGSAGHMTlgVTLMIGCITCIFSLICALALayldRRAEKILHKEQ 246
Cdd:cd17353 123 -------DKRGLATGIVIAGFGLGSlifsplIAYLINTVGVPT--TFLILGIIFLIIIVIGAFLI----RDPPKGWVPPG 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 247 GKTGEVIKLRDIKDFSLP----------LILVFVICVCYYVAVfpfIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMS 316
Cdd:cd17353 190 VDPLANNAENSPRDYTPRemlrtptfwlLWLMFFLNATAGLML---IGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 317 PLFGLLVDKTG-KNIIWVLYAVAAtlVSHMMLAFTFWNPW---IAMCLLGFSYSllacALWPMVAFIVPEH----QLGTA 388
Cdd:cd17353 267 PFWGWLSDKIGrKNTLSIAFLIQG--VAMFLLPFIGSVAVlfvLGVALIGFCYG----GGFALFPALTADFfgtkNAGTN 340
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 21313266 389 YGFMQSIQNLGLAVIAILAGMILDSKGYlllEVFFIACVSLSLLAVVCLYLV 440
Cdd:cd17353 341 YGLLYTAKGVGGLIGPIIAAYVLYTGGY---NAAFIIAAALSLVALALALLL 389
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
289-444 |
1.13e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.08 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 289 FFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKN-IIWVLYAVAATLVSHMMLAFTFWNPWIAMCLLGFSYSL 367
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRyLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 368 ---LACALwpmvAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGYLLLEVFFIacvsLSLLAVVCLYLVNRAQ 444
Cdd:cd17478 101 fhpEGARL----ASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLI----IPGLAVALLLLRLRPL 172
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
278-444 |
1.14e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.14 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 278 AVFPFIGlgkVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNIIWVLYAVAATLVshMMLAFTFWNPW-- 355
Cdd:cd17329 17 MVWPFMA---IYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG--FALLGFAHSPWlf 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 356 -IAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDskgYLLLEVFFIACVSLSLLAV 434
Cdd:cd17329 92 aIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL---YSFRLLFLAAAVLFLLAAL 168
|
170
....*....|
gi 21313266 435 VCLYLVNRAQ 444
Cdd:cd17329 169 VLLFLLPETR 178
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
41-437 |
1.33e-04 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 43.93 E-value: 1.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 41 RLVVLSLMCFLGFGSYFCYDNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRIfGIRWGTVIFSCFVC 120
Cdd:cd17334 2 RWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKV-GLRIGVLIGAALNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 121 IGQVI-FALGGIFNAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYGKIE 199
Cdd:cd17334 81 LGSVLkCIPLGQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVPPPK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 200 allGSAGHMTLGVTLMIGCITCIFSLICALALAYLDRRAEKILHKEQGKTGEVIKLRDIKDFSLPLILVFVICVCYYVAV 279
Cdd:cd17334 161 ---GTKKEFGAVFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQNSEHVILELQKSISELLRNEPFVLLAVAFSIMM 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 280 FPFIGLGKVF--FMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTgKNIIWVLYavaaTLVSHMMLAFTFWNPWIA 357
Cdd:cd17334 238 GVFAGFSSVLaqILLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRT-RMFKLIGL----IILALGTVVCTFFMLLVD 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 358 MCLLG-------FSYSLLACALWPMV----------AFIVPEhqlGTAYG----FMQSIQNLGLAVIAILAGMILDSKGY 416
Cdd:cd17334 313 RYGLPyvtlafyLLCGLLGFFQNSMVpimfelavelTYPVPE---SVSTGvltaLANLFSFLLMLVFSELLGPTPTESKY 389
|
410 420
....*....|....*....|.
gi 21313266 417 LLLevfFIACVSLSLLAVVCL 437
Cdd:cd17334 390 LLW---FILCTVGSCLGALFF 407
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
113-406 |
1.41e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 44.16 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 113 VIFSCFVCIGQVIFALGGIFNAFWLMELgRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNmNLMG 192
Cdd:cd17327 73 WLSVFIVLWGLLTLLTAAVKNFGGLIAL-RFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFG-GLLA 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 193 WLYGKIEALLGSAGHMTLgvTLMIGCITCIFSLICALAL------AYLDRRAEKILHKE------QGKTGEVIKLRDI-- 258
Cdd:cd17327 151 YGVFKILGVGGLAGWRWL--FIIEGLITIIIGLVIFFWLpdnpskAWFLTEEEKELAVErlranqTGKGDQKFKWKQIke 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 259 --KDFSLPLILVFVICV-----CYYVAVFPFIGLGKvffmekfrFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNII 331
Cdd:cd17327 229 afKDPRTWLLFLFFFCSqitnnGISNFLPLILKSLG--------FYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGL 300
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21313266 332 WVLYAVAATLVSHMMLAFTFWNP---WIAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAIL 406
Cdd:cd17327 301 FAIFACVLALVGSIILLAAPNPPgayFAAYILGGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAPQI 378
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
118-435 |
1.53e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 43.75 E-value: 1.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 118 FVCIGQVIFALG----GIFNAFWLMELGRFVFGIGGeSLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGW 193
Cdd:cd17490 64 FIIIGLLFTVLAslimILFPSPWGLLIARFLSGIAA-ATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGL 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 194 LygkieallgsAGHMTLGVTLMIGCITCIFSLICALALAYLDRRAEKILHKEQgKTGEVIKLRDIKDFSLPLILVFVICv 273
Cdd:cd17490 143 I----------AEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELK-ELLSVLKDKKLLFFSLLAILQQMIT- 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 274 cyYVAVFPFIGLgkvfFMEKFrFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNIIWVLYAVAATL-VSHMMLAFTFW 352
Cdd:cd17490 211 --FSTTFGFTPL----IAKQL-GASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLgAYCFLIPFAPN 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 353 NPWI--AMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGylLLEVFFIACVsLS 430
Cdd:cd17490 284 LTLLylLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFG--LQTGFFVIGV-IA 360
|
....*
gi 21313266 431 LLAVV 435
Cdd:cd17490 361 LLAAI 365
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
310-440 |
1.85e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 43.72 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 310 IISAPMSPLFGLLVDKTGKNIIwVLYAVAATLVSHMMLAFTFWNPW---IAMCLLGFSYSLLACALWPMVAFIVPEHQLG 386
Cdd:cd17504 228 LVMLIAGPLAGRLIARVGPRRV-LLIGLVISAVGLLLLALLHSSLWalvVALLLIGIGLGLAFASLPNIVVESVPPDRTG 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21313266 387 TAYGFMQSIQNLGLAVIAILAGMILDS-------------KGYLLLevfFIACVSLSLLAVVCLYLV 440
Cdd:cd17504 307 IATGMNTVLRTIGSAIGPAIAGAILTTytvsitsggvpteGAYVLA---FLIGAALALAALLLSLLI 370
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
92-434 |
3.02e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.93 E-value: 3.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 92 VVLCFLGGFLIDRIFGIRwgtvIFSCFVCIGQVIFALGGIFNAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGKELNL 171
Cdd:cd17477 45 LLGSPLVPRLIRRVGHIR----AFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 172 VFGLQLSMARIGSTVNmnlmgwlygkiEALLGSAGHMTLGVTLMIGCITCIfslicALALAYLDRRAEKILHKEqgktgE 251
Cdd:cd17477 121 VLGLYSTVLGLGFALG-----------PLLLALVGTAGALPFLIAAVLLLL-----ALVPLLLTRRAAPEIEEA-----E 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 252 VIKLRDIKDFSlplILVFVICVCYYVAVFPFIGLGKVFFMEKfRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNII 331
Cdd:cd17477 180 SISLRRLLRIA---PLALLGAFVAGFLEGAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 332 WVLYAVAATLVShMMLAFTFWNPWIAMCLL----GFSYSLLACALwPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILA 407
Cdd:cd17477 256 LLGCALLGALAA-LLLPLVPGLPLALLVLLflwgGAAGPLYTLAL-ALAGDRLPGDELVAANAALLLLYGLGSVIGPLLA 333
|
330 340
....*....|....*....|....*..
gi 21313266 408 GMILDSKGYLLLEVFFIACVSLSLLAV 434
Cdd:cd17477 334 GALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
278-436 |
3.40e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 42.57 E-value: 3.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 278 AVFPFIGLgkvfFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNIIWVLYAVAATLVSHMMLAFTFWNPWIA 357
Cdd:cd17335 15 SLLPFLSV----YLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQIFWLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 358 MCLLGFsYSLLACALWPMVAFIVPEH--QLGTAYGFMQSIQNLGLAVIAILAGMILD-SKGYLLLEVFFIACVSLSLLAV 434
Cdd:cd17335 91 LLLVIL-GAFFSAPVVPLVDSITLQYlgEERERYGKQRLWGSIGFGIAALLVGILIDrSSTYKNYTIAFYVFAVLMLLAL 169
|
..
gi 21313266 435 VC 436
Cdd:cd17335 170 LL 171
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
117-435 |
6.04e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 41.79 E-value: 6.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 117 CFVCIGQVIFALGGifnAFWLMELGRFVFGIGGESLAVAQnTYAVSWFKGKELNLVFGLqLSMARIGSTVnmnlmgwlyg 196
Cdd:cd17330 72 AGSAVSYVLLGLSR---NLWLLFLARFLDGLTGGNVSVAQ-AYIADITDEEERAKAFGI-ISAAFGLGFI---------- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 197 kiealLGSAGHMTLGVTLMIGCITCIFSLICALALAYLdrraekilhkeqgktgevikLRDIKDFSLPLILVFVICVCY- 275
Cdd:cd17330 137 -----LGPALGGFLSTPYGYALPFLVAAALALLNLVLV--------------------LFFLPPLRRLLLVYFLIALAFa 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 276 -YVAVFPFiglgkvFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNIIWVLYAVAATLVSHMMLAF--TFW 352
Cdd:cd17330 192 gLESVFSL------FLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFasSVP 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 353 NPWIAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGYLLleVFFIACVSLSLL 432
Cdd:cd17330 266 LLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGV--PFLLAAGLLLIA 343
|
...
gi 21313266 433 AVV 435
Cdd:cd17330 344 LFL 346
|
|
| MFS_unc93_like |
cd17338 |
Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is ... |
42-428 |
6.55e-04 |
|
Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is composed of Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93) and similar proteins including three vertebrate members: protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. The unc93-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340896 [Multi-domain] Cd Length: 388 Bit Score: 41.95 E-value: 6.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 42 LVVLSLMCFLGFGSYFCYDNpaaLQTQVKRDmQVNTTKFMLLYAWYSwpnvVLCFLGGFLIdRIFGIRWGTVIFSCfvci 121
Cdd:cd17338 1 VIILSFGFLLIFLAYSALQN---LQTSLHEN-GLGSISLGILYSSFA----VSSFIAPLLV-KLLGEKITLVLGGL---- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 122 GQVIFALGGIFNAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYGKieaL 201
Cdd:cd17338 68 GYAIFIASNIFPIWGTLVPASIILGFAAAILWTAQGTYITRISDESNIGRNFGIFWSIFQLSQVFGNLISLALLNH---S 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 202 LGSAGHMTLGVTLMigcitciFSLICALALAYLDRRAEKILHKEQGKTGEVIKLRDIKDFSLPLILVFVICVCYYVAVFP 281
Cdd:cd17338 145 KGSSGTTILFIVFM-------AIMLVGIILLFFLRGPDNEVITEIESSSVGESMEKKNLFKLPFTLLKDKRFLLLIPLLI 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 282 FIGLGKVFFMEKF-------RFSSQSASAINSIVYIISAPMSPLFGLLVD-KTGKNII----WVLYAVAATLVSHMMLAF 349
Cdd:cd17338 218 YSGLEQTFFSGVFtliigtpTTGIARVGYVMAVYGFGDALGSLVAGLLSDwRFGRIVLavigAFVHIASLILLFLSGNVT 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 350 TF-----WNPWIAMCLLGFSYSLLACALWPMVAFIVPEHQLGtAYGFMQSIQNLGlAVIAILAGMILDSKGYL--LLEVF 422
Cdd:cd17338 298 PYglggsWLAYVSAILWGLGDAIFNTQIYALLGSLYENDSES-AFAVYKLWQSIA-TAIAYFLSPYLPLFVKLfvLLALL 375
|
....*.
gi 21313266 423 FIACVS 428
Cdd:cd17338 376 ILLAIF 381
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
41-435 |
6.90e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 41.88 E-value: 6.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 41 RLVVLSLMCFLGFGSYFCYDNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRiFGIRWgTVIFSCFVC 120
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDR-SNIRR-FMSAGLLLS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 121 IGQVIFAlgGIFNAFWLMELGRFVFGIGgESLAVAQNTYAVS-WFKGKELNLVFGLQLSMARIGSTVNMNLMGWL---YG 196
Cdd:cd17312 79 ALANIFM--GFSTSLWFFAVLWGLNGLF-QSMGWPPCVKLLGnWFSKKERGTVYGIWSTSHNFGGILAPILAASLasyYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 197 KIEALLGSaghmtlgvtlmiGCITCIFSLICalalayldrraekilhkeqgktgeVIKLRDikdfSLPLILVFVIC-VCY 275
Cdd:cd17312 156 WRAAFLVP------------GIVGLVVAIIL------------------------FFFLRD----SPPYVWVLSLAyAFV 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 276 YVAVFPFIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGK---NIIWVLYAVAATLVshMMLAFTFW 352
Cdd:cd17312 196 YIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGgrrAPIAVIYMLLMTLS--LALFWFFP 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 353 NPW----IAMCLLGFSYSLLACALWPMVAFIVPEHQ-LGTAYGFMQSIQNLGLAVIAILAGMILDSKGYLLLEVFFIACV 427
Cdd:cd17312 274 HNKllsiVLLFLIGFFVGGPINLIGGAAAQDIGRKEaAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAA 353
|
....*...
gi 21313266 428 SLSLLAVV 435
Cdd:cd17312 354 LLSVLLLL 361
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
296-440 |
7.00e-04 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 42.22 E-value: 7.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 296 FSSQSASAINSIVYIISA----P---MSPLFGLLVDKTGKNIIWVLYAVAATLVSHMM-LAFTFWNPWIAMC---LLGFS 364
Cdd:PRK08633 37 IKAYDGSEQVILTAIVNAlfllPfllLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIvLAYYLGWFWLAFAvtfLLGAQ 116
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21313266 365 YSLLACALWPMVAFIVPEHQLGTAYGFMQSIqnlglAVIAILAGMILDSkgyLLLEVFFIACVS--LSLLAVVCLYLV 440
Cdd:PRK08633 117 SAIYSPAKYGIIPELVGKENLSRANGLLEAF-----TIVAILAGTALFS---FLFESVNGNTPSeiLGRIAPAGLVLL 186
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
67-440 |
8.37e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 8.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 67 TQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRiFGIRWgtVIfscfvCIGQVIFALGGIF----NAFWLMELGR 142
Cdd:cd17474 23 PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADR-FGRKK--VL-----LPGLLLFGIGGLLcglsDSFALLLAGR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 143 FVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNmnlmgwlygkieALLGsaghmtlGVTLMIGCITCI 222
Cdd:cd17474 95 ALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG------------PLLG-------GLLAAISWRYPF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 223 FSLICALALAYLdrrAEKILHKEQGKTGEVIKLRDIKDFSL-----PLILVFVICVCYYVAVFPFIGLGKVFFMEKFRFS 297
Cdd:cd17474 156 FLLAALIPVAFL---AILFLLPEPKEKAKSSSATKLRDLKKalrgrGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGIS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 298 SQSASAINSIVYIISAPMSPLFGLLVDKTGKNIIWVLYAVAATLVSHMMLAFTFWNPWIAMCLLGFSYSLLAC--ALWPM 375
Cdd:cd17474 233 PIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNlpLLTTL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21313266 376 VAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGyllLEVFFIACVSLSLLAVVCLYLV 440
Cdd:cd17474 313 VTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG---LSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
300-440 |
1.30e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.06 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 300 SASAINSIVYIISAPM---SPLFGLLVDKTG-KNIIWVLYAV-AATLVSHMMLAFTFWNPWIAMCLLGFSYSLLACALWP 374
Cdd:cd06173 32 SALLVGLVLAAFFLPFllfSPFAGVLADRFDrRRLLILADLLrALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 375 ----MVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILdskGYLLLEVFFIACVSLSLLAVVCLYLV 440
Cdd:cd06173 112 arqaLLPELVPKEQLVRANALNSLATQLARIIGPALGGLLV---ALLGPGGAFAINALSFLLSALLLLFI 178
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
82-439 |
1.78e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.29 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 82 LLYAWYSWPNVVLCFLGGFLIDRiFGIRW---GTVIFSCFVCIGQVIFALGGIFNaFWLMELGRFVFGIGGESLAVAQNT 158
Cdd:cd06173 38 LVLAAFFLPFLLFSPFAGVLADR-FDRRRlliLADLLRALLAAVLALLALLGSLS-LWLLLVLAFLLGIASAFFGPARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 159 YAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYGkieallgsagHMTLGVTLMIGCITCIFSLICALALAYLDRRA 238
Cdd:cd06173 116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVA----------LLGPGGAFAINALSFLLSALLLLFIRRPPPAA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 239 EKilHKEQGKTGEVIKLRDIKDFSLPLILVFVICVCYYVAVFPFIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMSPL 318
Cdd:cd06173 186 PG--ESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 319 FGLLVDKTGKnIIWVLYAVAATLVSHMMLAFTFWNPW--IAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQ 396
Cdd:cd06173 264 LGRLSKRRRR-GRLLLIGALLLGLALLVLGLSPSLWLllAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALN 342
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 21313266 397 NLGLAVIAILAGMILDSKGYLLleVFFIACVSLSLLAVVCLYL 439
Cdd:cd06173 343 SGAMPLGALLAGLLADALGLSA--VFLLAGALLLLAALLLLLL 383
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
41-186 |
2.08e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.34 E-value: 2.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 41 RLVVLSLMCFLGFGSYFCYdnPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRiFGIRWGTVIFSCFVC 120
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFAL--FTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR-FGRRRLLLIGLLLLA 284
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21313266 121 IGqviFALGGIFNAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTV 186
Cdd:COG2814 285 LG---LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
41-229 |
2.28e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.89 E-value: 2.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 41 RLVVLSLMCFLGFGSYFCYdnPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRIfGIRWGTVIFSCFVC 120
Cdd:cd17316 178 RTLLLILLWFFISFGYYGL--TTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI-GRKKTLVIGLILSG 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 121 IGQVIFALGGIFNAFWLMeLGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLygkiea 200
Cdd:cd17316 255 ILALPLFYLLSGSPTLLL-LLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL------ 327
|
170 180
....*....|....*....|....*....
gi 21313266 201 llgSAGHMTLGVTLMIGCITCIFSLICAL 229
Cdd:cd17316 328 ---LASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
99-435 |
2.60e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.95 E-value: 2.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 99 GFLIDRiFGIRWGTVIFSCFVCIGQVIFALGgifNAFWLMELGRFVFGIGGES-LAVAQNTYAVSWFKGKELNLVFGLQL 177
Cdd:cd17355 59 GRLLDR-FGPRRVMLLGLLLLAAGLVLLALA---TSLWQLYLLWGLLGGGGAGtLAAVAFATVAAWWFERRRGLALGILT 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 178 SMARIGSTVNMNLMGWLygkIEALLGSAGHMTLGvtlmigcitcIFSLICALALAYLDRR-------AEKILHKEQGKTG 250
Cdd:cd17355 135 AGGGLGSLVFLPLGAAL---IEAFGWRTALLVLA----------LLALLVLVPVLLLLRRrpadlalRAYDDASPASPGS 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 251 EVIKLRDIKDFSLpLILVFVICvCYYVAvfpFIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNI 330
Cdd:cd17355 202 TLKEALRSASFWL-LALAFFLC-GFAVV---GLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRR 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 331 IWVLYAVAATLvshmMLAFTFWNPWIAMCLLGFS--YSLLACALWPMVAFIVPE----HQLGTAYGFMQSIQNLGLAVIA 404
Cdd:cd17355 277 LLAASYALRAL----GLALLLLLPFPPLALLLFAalFGLGWGATVPLTAALAARyfgaRSYGTLFGLVFAPHQLGSALGP 352
|
330 340 350
....*....|....*....|....*....|.
gi 21313266 405 ILAGMILDSKGYLLLEvfFIACVSLSLLAVV 435
Cdd:cd17355 353 WLGGLLYDRTGSYTAA--WALAVALGLIAAL 381
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
252-410 |
4.80e-03 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 39.21 E-value: 4.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 252 VIKLRDIKD--FSLPLILVFVICVCYYVAVFPFIglgkVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKN 329
Cdd:cd17322 276 FLPFRLLKDrtILAACLIDFFYFFSYYIFSDYLY----TVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRRY 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 330 IIWV-----LYAVAATLVSHMMLAFTFWNPWI-AMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVI 403
Cdd:cd17322 352 KVLViigvpLYIVGMGLLIRYRGGSGSHGGIIgALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVG 431
|
....*..
gi 21313266 404 AILAGMI 410
Cdd:cd17322 432 AAISGAI 438
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
294-413 |
5.09e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 38.82 E-value: 5.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21313266 294 FRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNIiWVLYAVAATLVSHMMLAFTFWNPWIAMC---LLGFSYSLLAC 370
Cdd:TIGR00886 32 LGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRY-TTALSLLLLAIPCLWAGLAVQSYSVLLLirlFIGIAGGSFAS 110
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 21313266 371 ALwPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDS 413
Cdd:TIGR00886 111 CM-PWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGS 152
|
|
| |
