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Conserved domains on  [gi|294661878|ref|NP_079913|]
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RWD domain-containing protein 3 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RWDD3_C cd24164
RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small ...
 212-319 1.24e-54

RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small protein containing an N-terminal RWD domain and a C-terminal domain of unknown function. RWDD3 acts by modulating post-translational modification (PTM) of proteins, and it also plays a role in tumorigenesis. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


:

Pssm-ID: 467815  Cd Length: 110  Bit Score: 174.34  E-value: 1.24e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661878 212 WMTLLRLDHMRARTKYVKAVEKWASELRLTGRLMFMGKLILILLQGDRSNIKEYLILQKTSKVDVDSSGKKCKEKMISVL 291
Cdd:cd24164    2 ETVLLRLDHMRAKAKYVKTLKKWTQELGLTGRLIFYGKLILILLQGTSENIKKYLVRLRTEKVDVDSRGRPCKERMMTVL 81

                         90       100
                 ....*....|....*....|....*....
gi 294661878 292 SETKVQT-EHKRFLAFEVKEYSTLEELQK 319
Cdd:cd24164   82 GERKVPTcEKSGFTEFEVLEPSSLEELLV 110
RWD_DRWD_ELF-like super family cl45901
RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF ...
 94-184 2.32e-28

RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF domains. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. The RWD domain (named after three major RWD-containing proteins: RING finger, WD-repeat-containing proteins and DEXD-like helicases) mediates protein-protein interactions in a variety of pathways in eukaryotes. The DRWD domain is responsible for substrate binding. It is involved in interactions with other kinetochore proteins. The ELF (N-terminal E2-like fold) domain is found in all Fanconi anemia group L protein (FANCL) homologs. It is required to promote efficient DNA damage-induced FANCD2 (Fanconi anemia group D2 protein) monoubiquitination in vertebrate cells.


The actual alignment was detected with superfamily member cd23819:

Pssm-ID: 480265  Cd Length: 106  Bit Score: 105.87  E-value: 2.32e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661878  94 ETFSSNPETDGAVFRIHTTAEGlVGEDVPLELAFHLPVGYPLCLPGISVTSEHLTRAQCVTAKEKLLGEARKLVSEPMVH 173
Cdd:cd23819   17 EVLSSSETSDGVSFKIQISVEG-FDEDIVLKLTFHLSPNYPSSLPDISVSSEQLTRAQCNDLQDSLLEYANSLLGEPMVL 95

                         90
                 ....*....|.
gi 294661878 174 ELVLWIQQNLR 184
Cdd:cd23819   96 ELVLWLQENLL 106
 
Name Accession Description Interval E-value
RWDD3_C cd24164
RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small ...
 212-319 1.24e-54

RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small protein containing an N-terminal RWD domain and a C-terminal domain of unknown function. RWDD3 acts by modulating post-translational modification (PTM) of proteins, and it also plays a role in tumorigenesis. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467815  Cd Length: 110  Bit Score: 174.34  E-value: 1.24e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661878 212 WMTLLRLDHMRARTKYVKAVEKWASELRLTGRLMFMGKLILILLQGDRSNIKEYLILQKTSKVDVDSSGKKCKEKMISVL 291
Cdd:cd24164    2 ETVLLRLDHMRAKAKYVKTLKKWTQELGLTGRLIFYGKLILILLQGTSENIKKYLVRLRTEKVDVDSRGRPCKERMMTVL 81

                         90       100
                 ....*....|....*....|....*....
gi 294661878 292 SETKVQT-EHKRFLAFEVKEYSTLEELQK 319
Cdd:cd24164   82 GERKVPTcEKSGFTEFEVLEPSSLEELLV 110
RWD_RWDD3 cd23819
RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called ...
 94-184 2.32e-28

RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called RWD domain-containing sumoylation enhancer (RSUME), acts as an enhancer of SUMO conjugation and has no effect on ubiquitination. It increases protein sumoylation (a dynamic ubiquitin-like post translational modification) of several proteins including HIF1alpha and I-kappa-B, through direct interaction with UBC9. Its RWD domain is required for the sumoylation enhancement activity.


Pssm-ID: 467655  Cd Length: 106  Bit Score: 105.87  E-value: 2.32e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661878  94 ETFSSNPETDGAVFRIHTTAEGlVGEDVPLELAFHLPVGYPLCLPGISVTSEHLTRAQCVTAKEKLLGEARKLVSEPMVH 173
Cdd:cd23819   17 EVLSSSETSDGVSFKIQISVEG-FDEDIVLKLTFHLSPNYPSSLPDISVSSEQLTRAQCNDLQDSLLEYANSLLGEPMVL 95

                         90
                 ....*....|.
gi 294661878 174 ELVLWIQQNLR 184
Cdd:cd23819   96 ELVLWLQENLL 106
RWD pfam05773
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ...
 97-183 1.99e-10

RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.


Pssm-ID: 399058  Cd Length: 111  Bit Score: 57.33  E-value: 1.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661878   97 SSNPETDGAVFRIHTTA-EGLVGEDVPLELAFHLPVGYPLCLPGISVTS-EHLTRAQCVTAKEKLLGEARKLVSEPMVHE 174
Cdd:pfam05773  23 DSPYESLEIEIKLSLDSdESDSSHLPPLVLKFTLPEDYPDEPPKISLSSpWNLSDEQVLSLLEELEELAEENLGEVMIFE 102


                  ....*....
gi 294661878  175 LVLWIQQNL 183
Cdd:pfam05773 103 LIEWLQENL 111
RWD smart00591
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ...
 107-184 6.46e-08

domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;


Pssm-ID: 214735  Cd Length: 107  Bit Score: 50.05  E-value: 6.46e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 294661878   107 FRIHTTAEGLVGEDVPLELAFHLPVGYPLCLPGISVTS-EHLTRAQCVTAKEKLLGEARKLVSEPMVHELVLWIQQNLR 184
Cdd:smart00591  27 IKLSPSSDEGEDQYVSLTLQVKLPENYPDEAPPISLLNsEGLSDEQLAELLKKLEEIAEENLGEVMIFELVEKLQEFLS 105
DUF1115 pfam06544
Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical ...
 218-330 7.01e-03

Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 461943  Cd Length: 135  Bit Score: 36.50  E-value: 7.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661878  218 LDHMRARTKyvkaVEKWASELRLTGRLMFMGKLILILLQGDRSNIKEY--LILQ----KTSKVDVDSSGKKCKEKMISVL 291
Cdd:pfam06544   8 LSNPKHRFK----IDKNAKQLGLTGFCILGPPFGLVVVEGGEKSIKKYkkLMLRrikwTENPHEDFEAMKEITFEWDNDE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 294661878  292 SETKV----------QTEHKRFLAFEVKEYSTLEELQKEFGAAGLGELF 330
Cdd:pfam06544  84 DNEGEdnkcelvwegEVKERAFRKWKFKVCETEGEAREFLKKHGVEHYW 132
 
Name Accession Description Interval E-value
RWDD3_C cd24164
RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small ...
 212-319 1.24e-54

RWD domain-containing protein 3, C-terminal domain; RWDD3, also called RSUME, is a small protein containing an N-terminal RWD domain and a C-terminal domain of unknown function. RWDD3 acts by modulating post-translational modification (PTM) of proteins, and it also plays a role in tumorigenesis. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467815  Cd Length: 110  Bit Score: 174.34  E-value: 1.24e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661878 212 WMTLLRLDHMRARTKYVKAVEKWASELRLTGRLMFMGKLILILLQGDRSNIKEYLILQKTSKVDVDSSGKKCKEKMISVL 291
Cdd:cd24164    2 ETVLLRLDHMRAKAKYVKTLKKWTQELGLTGRLIFYGKLILILLQGTSENIKKYLVRLRTEKVDVDSRGRPCKERMMTVL 81

                         90       100
                 ....*....|....*....|....*....
gi 294661878 292 SETKVQT-EHKRFLAFEVKEYSTLEELQK 319
Cdd:cd24164   82 GERKVPTcEKSGFTEFEVLEPSSLEELLV 110
Prp3_C-like cd24140
C-terminal domain of Prp3 and related proteins; This group contains the C-terminal domains of ...
 212-318 5.29e-36

C-terminal domain of Prp3 and related proteins; This group contains the C-terminal domains of Prp3 and RWD domain-containing proteins 2/3. Predicted structures (by AlphaFold) of the C-terminal domains of RWDD2 and RWDD3 reveal similarity to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467812  Cd Length: 117  Bit Score: 126.61  E-value: 5.29e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661878 212 WMTLLRLDHMRARTKYVKAVEKWAsELRLTGRLMFMGKLILILLQGDRSNIKEYLILQKTSKVDVDSSGK--------KC 283
Cdd:cd24140    2 HCKVFHFKHLQNKKKRFKIKENSK-ELSLKGLCMRIRDPGIIIVVGNEKSCKEYENLVKKRKWNEDFELHtntgdikeKC 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 294661878 284 KEKMISVLSETKVQT--EHKRFLAFEVKEYSTLEELQ 318
Cdd:cd24140   81 HNNSISKTWEGYLQDckFKGWFLKVCNDQYSLLRTLG 117
RWD_RWDD3 cd23819
RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called ...
 94-184 2.32e-28

RWD domain of RWD domain-containing protein 3 (RWDD3) and related proteins; RWDD3, also called RWD domain-containing sumoylation enhancer (RSUME), acts as an enhancer of SUMO conjugation and has no effect on ubiquitination. It increases protein sumoylation (a dynamic ubiquitin-like post translational modification) of several proteins including HIF1alpha and I-kappa-B, through direct interaction with UBC9. Its RWD domain is required for the sumoylation enhancement activity.


Pssm-ID: 467655  Cd Length: 106  Bit Score: 105.87  E-value: 2.32e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661878  94 ETFSSNPETDGAVFRIHTTAEGlVGEDVPLELAFHLPVGYPLCLPGISVTSEHLTRAQCVTAKEKLLGEARKLVSEPMVH 173
Cdd:cd23819   17 EVLSSSETSDGVSFKIQISVEG-FDEDIVLKLTFHLSPNYPSSLPDISVSSEQLTRAQCNDLQDSLLEYANSLLGEPMVL 95

                         90
                 ....*....|.
gi 294661878 174 ELVLWIQQNLR 184
Cdd:cd23819   96 ELVLWLQENLL 106
RWD pfam05773
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ...
 97-183 1.99e-10

RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.


Pssm-ID: 399058  Cd Length: 111  Bit Score: 57.33  E-value: 1.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661878   97 SSNPETDGAVFRIHTTA-EGLVGEDVPLELAFHLPVGYPLCLPGISVTS-EHLTRAQCVTAKEKLLGEARKLVSEPMVHE 174
Cdd:pfam05773  23 DSPYESLEIEIKLSLDSdESDSSHLPPLVLKFTLPEDYPDEPPKISLSSpWNLSDEQVLSLLEELEELAEENLGEVMIFE 102


                  ....*....
gi 294661878  175 LVLWIQQNL 183
Cdd:pfam05773 103 LIEWLQENL 111
RWD_DRWD_ELF-like cd11605
RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF ...
 93-179 6.63e-09

RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF domains. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. The RWD domain (named after three major RWD-containing proteins: RING finger, WD-repeat-containing proteins and DEXD-like helicases) mediates protein-protein interactions in a variety of pathways in eukaryotes. The DRWD domain is responsible for substrate binding. It is involved in interactions with other kinetochore proteins. The ELF (N-terminal E2-like fold) domain is found in all Fanconi anemia group L protein (FANCL) homologs. It is required to promote efficient DNA damage-induced FANCD2 (Fanconi anemia group D2 protein) monoubiquitination in vertebrate cells.


Pssm-ID: 467641  Cd Length: 94  Bit Score: 52.57  E-value: 6.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661878  93 METFSSNPETDGAVFRIHTTAEGLvGEDVPLELAFHLPVGY-PLCLPGISVTSEHLTRAQCVTA-KEKLLGEARKLVSEP 170
Cdd:cd11605    7 GDELEVLSDDSPLRFSIRLSPEEE-EDDPPLELEFTLPPGYpPEEPPLITLRSPKLSSAERLSLlKLELEEAAEENLGEP 85


                 ....*....
gi 294661878 171 MVHELVLWI 179
Cdd:cd11605   86 MLFDLVEAL 94
RWD smart00591
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ...
 107-184 6.46e-08

domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain;


Pssm-ID: 214735  Cd Length: 107  Bit Score: 50.05  E-value: 6.46e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 294661878   107 FRIHTTAEGLVGEDVPLELAFHLPVGYPLCLPGISVTS-EHLTRAQCVTAKEKLLGEARKLVSEPMVHELVLWIQQNLR 184
Cdd:smart00591  27 IKLSPSSDEGEDQYVSLTLQVKLPENYPDEAPPISLLNsEGLSDEQLAELLKKLEEIAEENLGEVMIFELVEKLQEFLS 105
RWD_RWDD2 cd23829
RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; ...
 107-183 1.76e-07

RWD domain of RWD domain-containing protein 2A (RWDD2A), 2B (RWDD2B) and related proteins; This subfamily includes RWDD2A, previously known as RWD domain-containing 2 (RWDD2) and RWDD2B, previously known in humans as chromosome 21 open reading frame (C21orf6). C21orf6 appears to be involved in monosomy 21 phenotype. The RWD domain may mediate protein-protein interactions.


Pssm-ID: 467663  Cd Length: 129  Bit Score: 49.49  E-value: 1.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661878 107 FRIHTTAEGlvgEDVPLELAFHLPVGYPLCLPGISVTSEHLTRAQcvtakEKLLGEA-----RKL-VSEPMVHELVLWIQ 180
Cdd:cd23829   51 FTINLKIEE---PKVKVELSVTLPHEYPSVPPEIFVRSDSLSRSQ-----QRQLNEDlseyiSSLeRGELCILQIVQWLQ 122


                 ...
gi 294661878 181 QNL 183
Cdd:cd23829  123 DNA 125
RWD_GCN2 cd23823
RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called ...
 93-183 7.81e-07

RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4), acts as a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability. It also plays a role in modulating the adaptive immune response to yellow fever virus infection and promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation.


Pssm-ID: 467659  Cd Length: 117  Bit Score: 47.21  E-value: 7.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661878  93 METFSSNPETDGAV----FRIHTTAEGLVGE--DVPLELAFHLPVGYPLCLPGISVTSEH-LTRAQCVTAKEKLLGEARK 165
Cdd:cd23823   16 GDDFEDLSSKKAVWsppeFRIRLRPQEGESEenHVSVDLHVKFPPTYPDVPPEIELENVKgLSDEQLEELLKELEELAKE 95

                         90
                 ....*....|....*...
gi 294661878 166 LVSEPMVHELVLWIQQNL 183
Cdd:cd23823   96 LLGEEMIFELAEAVQEFL 113
RWDD2_C cd24163
C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small ...
 220-333 1.57e-06

C-terminal domain of RWD domain-containing protein 2; RWDD2A, as well as RWDD2B, are small proteins that contain an N-terminal RWD domain and a C-terminal domain of unknown function. The C-terminal domain is predicted (by AlphaFold) to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-terminal domain is a single-stranded RNA-binding domain.


Pssm-ID: 467814  Cd Length: 122  Bit Score: 46.48  E-value: 1.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661878 220 HMRARTKyVKAVEKWASELRLTGRLMFmGKLILILLQGDRSNIKEYL-ILQKTSKvdvdssgKKCK---EKMISVLSETK 295
Cdd:cd24163   10 HIYSKKK-RKDIVEWAKELGLTGFSKP-GKPGVICVEGDEEDVDEYVrRIRRLRW-------KKIQvrgEEVIEVPRFFG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 294661878 296 VQTEHKRFLAFEVKEYST--LEELQKEFGAAGLGELFSEC 333
Cdd:cd24163   81 EEEDEERALPGGFRELHEdlMGELAAFLEEAGLEELFLTL 120
RWD_YLR419W-like cd23827
RWD domain of Saccharomyces cerevisiae putative ATP-dependent RNA helicase YLR419W and related ...
 119-187 1.16e-05

RWD domain of Saccharomyces cerevisiae putative ATP-dependent RNA helicase YLR419W and related proteins; YLR419W (EC 3.6.4.13) may act as an ATP-binding RNA helicase. The RWD domain may mediate protein-protein interactions.


Pssm-ID: 467662  Cd Length: 104  Bit Score: 43.77  E-value: 1.16e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 294661878 119 EDVPLELAFHLPVGYPLCLPGISVTSE---------HLTRaQCVT-AKEKLLGearklvsEPMVHELVLWIQQNLRLVL 187
Cdd:cd23827   34 TKPSLKLKFYKSSSYPNSLPGIFISSSdklpayiklAIIR-QLLQyARDNLLG-------DPMIFSIVEWLEENIEEII 104
DUF1115 pfam06544
Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical ...
 218-330 7.01e-03

Protein of unknown function (DUF1115); This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.


Pssm-ID: 461943  Cd Length: 135  Bit Score: 36.50  E-value: 7.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 294661878  218 LDHMRARTKyvkaVEKWASELRLTGRLMFMGKLILILLQGDRSNIKEY--LILQ----KTSKVDVDSSGKKCKEKMISVL 291
Cdd:pfam06544   8 LSNPKHRFK----IDKNAKQLGLTGFCILGPPFGLVVVEGGEKSIKKYkkLMLRrikwTENPHEDFEAMKEITFEWDNDE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 294661878  292 SETKV----------QTEHKRFLAFEVKEYSTLEELQKEFGAAGLGELF 330
Cdd:pfam06544  84 DNEGEdnkcelvwegEVKERAFRKWKFKVCETEGEAREFLKKHGVEHYW 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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